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https://www.readbyqxmd.com/read/29775895/ozone-therapy-prevents-the-onset-of-dysplasia-in-hpv16-transgenic-mice-a-pre-clinical-efficacy-and-safety-analysis
#1
C Peirone, V F Mestre, B Medeiros-Fonseca, B Colaço, M J Pires, T Martins, R M Gil da Costa, M J Neuparth, R Medeiros, M M S M Bastos, J A Marques-Magallanes, P A Oliveira
Infection with high-risk human papillomavirus (HPV), most often HPV16, is associated with the development of anogenital and oropharyngeal cancers. Recently, ozone therapy was reported to have considerable efficacy against rabbit VX2 tumors, induced by the cottontail rabbit papillomavirus. The present study aims to determine whether similar results can be obtained in HPV16-transgenic mice, possibly paving the way for new therapeutic options against HPV-induced cancers. HPV16-transgenic and wild-type, female, 20 weeks-old mice were injected intraperitoneally with medical O3 /O2 (80░mL/kg, at O3 50░μg/mL), once a day, for 5 consecutive days...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29736142/medical-ozone-therapy-as-a-potential-treatment-modality-for-regeneration-of-damaged-articular-cartilage-in-osteoarthritis
#2
REVIEW
Sello Lebohang Manoto, Makwese Johaness Maepa, Shirley Keolebogile Motaung
Osteoarthritis (OA) is the most common degenerative joint disease and a growing health problem affecting more than half of the population over the age of 65. It is characterized by inflammation in the cartilage and synovium, resulting in the loss of joint structure and progressive damage to the cartilage. Many pro-inflammatory mediators are elevated in OA, including reactive oxygen species (ROS) such as nitric oxide (NO) and hydrogen peroxide (H2 O2 ). Damaged articular cartilage remains a challenge to treat due to the limited self-healing capacity of the tissue and unsuccessful biological interventions...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29729693/intradiscal-ozone-therapy-for-lumbar-disc-herniation
#3
Sibel Ozcan, Arzu Muz, Aysun Yildiz Altun, Selami Ates Onal
The rationale behind intradiscal O2-O3 therapy is the pain elicited by the mechanical compression of the nerve root, which is associated with periganglionic and periradicular inflammation. This study aimed to determine the effect of intradiscal ozone injection on pain score and satisfaction of patients with low back pain (LBP) secondary to disc herniation. Patients with LBP diagnosed with disc herniation were enrolled in this clinical trial. After prepping and draping the area, intradiscal injection of ozone/oxygen mixture (10 ml, 25μg/ml) was performed under fluoroscopy guide (c-arm)...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29697390/ultrastructural-changes-of-wound-macrophages-under-the-influence-of-intravenous-ozone-therapy-in-patients-with-diabetes-and-inflammatory-processes-of-soft-tissues
#4
S Karatieieva, N Muzyka, S Semenenko, O Bakun, I Kozlovskaya
Investigation of ultrastructural peculiarities of morpho-functional changes of macrophages have been studied with the purpose of determining the dynamics and thrust of destructive-necrotic processes in these cells when the ischemic-gangrenous form of diabetic foot syndrome develops show what under the influence of intravenous ozone therapy stimulant effect on functional activity and beneficial effect on elimination, mainly due to genetically programmed cell death (apoptosis), playing a significant role in the regulatory mechanisms of the inflammatory process...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29652047/-physical-therapy-of-psoriasis-the-modern-methodological-approaches
#5
I S Evstigneeva, A G Kulikov, O V Yarustovskaya, A S Shakhova, M G Lutoshkina
This article describes the modern approaches to the application of physical factors for the treatment of various forms of psoriasis taking into consideration the severity of clinical manifestations and the phase of the disease, the extent of disturbances of the functional state of different organs. The principles of prescription of physiotherapeutictreatmnt are formulated taking account of the stages and forms of the disease. Special attention is paid to the high therapeutic effectiveness of ultraviolet irradiation of the skin including narrow-band UVВ (311 nm) as well as to photodynamic therapy (PUVA), intravenous laser irradiation of blood, and ozone therapy...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29630128/therapeutic-dosage-of-ozone-inhibits-autophagy-and-apoptosis-of-nerve-roots-in-a-chemically-induced-radiculoneuritis-rat-model
#6
M-Y Wu, C-Y Xing, J-N Wang, Y Li, X-W Lin, Z-J Fu
OBJECTIVE: Radiculoneuritis characterizes by the neurogenic pain along the back of patients. This study aims to investigate the therapeutic effects of ozone on radiculoneuritis and the associated mechanisms in rat models. MATERIALS AND METHODS: A chemical radiculoneuritis rat model was successfully established. The rats were divided into 3 groups, including radiculoneuritis Model rats group (Model group, n=18), Ozone therapy group (n=18), and Normal control group (n=18)...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29628600/cardiopulmonary-arrest-and-pneumoencephaly-developing-after-epidural-oxygen-ozone-mixture-therapy
#7
Serbülent Gökhan Beyaz, Cafer Altaş, Havva Sayhan
Pain treatment can comprise a combination of pharmacological, interventional, surgical, physical, psycological methods. Interventional procedures, particularly minimally invasive percutaneous therapies, have been widely used in recent years. Corticosteroid, hyperbaric saline or oxygen-ozone therapy is a safe procedure for patients in whom pain cannot be relieved by epidural adhesiolysis or other treatments. Complication related to oxygen-ozone therapy have been reported rarely in lumbar sciatalgia. Herein, we present a patient who developed cardiopulmonary arrest and pneumoencephaly as a rare but life-threatening complication of oxygen-ozone therapy, for epidural lysis, applied to the epidural space due to low back pain...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29623928/effect-of-tibolone-pretreatment-on-kinases-and-phosphatases-that-regulate-the-expression-and-phosphorylation-of-tau-in-the-hippocampus-of-rats-exposed-to-ozone
#8
Rodolfo Pinto-Almazan, Julia J Segura-Uribe, Marvin A Soriano-Ursúa, Eunice D Farfán-García, Juan M Gallardo, Christian Guerra-Araiza
Oxidative stress (OS) is a key process in the development of many neurodegenerative diseases, memory disorders, and other pathological processes related to aging. Tibolone (TIB), a synthetic hormone used as a treatment for menopausal symptoms, decreases lipoperoxidation levels, prevents memory impairment and learning disability caused by ozone (O3 ) exposure. However, it is not clear if TIB could prevent the increase in phosphorylation induced by oxidative stress of the microtubule-associated protein Tau. In this study, the effects of TIB at different times of administration on the phosphorylation of Tau, the activation of glycogen synthase kinase-3β (GSK3β), and the inactivation of Akt and phosphatases PP2A and PTEN induced by O3 exposure were assessed in adult male Wistar rats...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29620177/gardenoside-combined-with-ozone-inhibits-the-expression-of-p2x3-and-p2x7-purine-receptors-in-rats-with-sciatic-nerve-injury
#9
Mingdong Yu, Yong Zhao, Xiaoxia Zhang
Neuropathic pain is a severe health problem for which there is a lack of effective therapy. Ozone and Gardenia fruits have been used separately in pain relief for many years; however, their underlying mechanisms remain unclear. To investigate the pain‑relieving effects of combined ozone and Gardenia, a chronic constriction sciatic nerve injury (CCI) rat model was constructed and treated with ozone and gardenoside (Ozo&Gar), which is a compound found in Gardenia fruits. A total of 70 rats were randomly divided into five groups: Control (Ctrl), Ctrl + Ozo&Gar, Sham, CCI, and CCI + Ozo&Gar...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29616749/impact-of-selected-magnetic-fields-on-the-therapeutic-effect-in-patients-with-lumbar-discopathy-a-prospective-randomized-single-blinded-and-placebo-controlled-clinical-trial
#10
Jakub Taradaj, Marcin Ozon, Robert Dymarek, Bartosz Bolach, Karolina Walewicz, Joanna Rosińczuk
BACKGROUND: Interdisciplinary physical therapy together with pharmacological treatment constitute conservative treatment strategies related to low back pain (LBP). There is still a lack of high quality studies aimed at an objective evaluation of physiotherapeutic procedures according to their effectiveness in LBP. OBJECTIVES: The aim of this study is to carry out a prospective, randomized, single-blinded, and placebocontrolled clinical trial to evaluate the effectiveness of magnetic fields in discopathy-related LBP...
March 23, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29584512/acute-prevertebral-abscess-secondary-to-intradiscal-oxygen-ozone-chemonucleolysis-for-treatment-of-a-cervical-disc-herniation
#11
Chun-Sheng Yang, Lin-Jie Zhang, Zhi-Hua Sun, Li Yang, Fu-Dong Shi
Objective We herein present a case involving a prevertebral abscess complicated by a spinal epidural abscess (SEA) secondary to intradiscal oxygen-ozone chemonucleolysis for treatment of a cervical disc herniation. Methods A 67-year-old woman with a history of intradiscal oxygen-ozone chemonucleolysis developed numbness and weakness in her right upper and bilateral lower extremities followed by urinary retention. Her symptoms did not respond to intravenous antibiotics alone. Magnetic resonance imaging of the cervical region revealed an extensive SEA anterior to the spinal cord, spinal cord myelopathy due to anterior compression by the lesion, and a prevertebral abscess extending from C2 to T1...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29578432/treatment-of-pyoinflammatory-complications-with-individually-selected-ozone-dose-in-patients-with-diabetes
#12
S Karatieieva, O Makarova, O Yurkiv, S Semenenko, M Berezova
The severity of purulent-inflammatory process in patients with diabetes mellitus is determined by lymphocytotoxic test. The test shows that application of intravenous ozone therapy with individually selected ozone dose significantly decreases the spread of necrotic suppurative focus already on the third day of treatment. Granulation tissue and marginal epithelization in the wound develops on the 6-8th day of hospitalization; normalization of glycemic levels shorten of the period of the hospital stay up to 3-5 days, compared to the control group...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29559601/-topical-ozone-therapy-an-innovative-solution-to-patients-with-herpes-zoster
#13
Jian Huang, Jinhua Huang, Yaping Xiang, Lihua Gao, Yizhi Pan, Jianyun Lu
To observe the clinical efficacy and safety of topical ozone therapy for patients with herpes zoster by reflectance confocal microscopy (RCM).
 Methods: A total of 60 patients with herpes zoster were divided into a control group and an ozone treatment group (n=30). In the control group, patients took oral valacyclovir tablets or granules (0.3 g per day, three times a day) and they were subjected to local weak laser irradiation treatment plus topical 2% mupirocin ointment twice a day. In the ozone group, the treatment is same as the control group except mupirocin ointment was replaced with topical ozone treatment (hydrotherapy every day plus ozonated oil twice a day)...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29559600/-topical-ozone-application-an-innovative-therapy-for-infantile-atopic-dermatitis
#14
Guizhi Qin, Jinhua Huang, Yizhi Pan, Yaping Xiang, Chunxiang Ou, Jian Huang, Lihua Gao, Jianyun Lu
To evaluate the clinical efficacy and safety of the innovative topical ozone therapy for infantile atopic dermatitis.
 Methods: Sixty children with atopic dermatitis were divided into a treatment group and a control group. The treatment group was showered with ozonated water (3-5 times a week) and smeared with ozonated oil (twice a day), while the control group was washed with warm running water and smeared with base oil, adding moisturizer if necessary. The treatment course was 2 weeks. Efficacy and side effect were evaluated...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29559599/-effect-of-ozone-on-staphylococcus-aureus-colonization-in-patients-with-atopic-dermatitis
#15
Jianyun Lu, Miaomiao Li, Jian Huang, Lihua Gao, Yizhi Pan, Zhibing Fu, Jianhua Dou, Jinhua Huang, Yaping Xiang
To verify the effect of ozone on Staphylococcus aureus (S. aureus) colonization in patients with atopic dermatitis (AD) and its correlation with the patient's status.
 Methods: A total of 12 patients with moderate or severe AD, aged from 6 to 65 years, were recruited from outpatient of the Third Xiangya Hospital. The treatment sides were showered with ozonated water and smeared with ozonated oil for 7 days (twice a day), while the control sides were washed with warm running water and smeared with base oil...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29559598/-curative-effect-of-ozone-hydrotherapy-for-pemphigus
#16
Fuqiong Jiang, Danqi Deng, Xiaolan Li, Wenfang Wang, Hong Xie, Yongzhuo Wu, Chunyan Luan, Binbin Yang
To determine clinical curative effects of ozone therapy for pemphigus vulgaris.
 Methods: Ozone hydrotherapy was used as an aid treatment for 32 patients with pemphigus vulgaris. The hydropathic compression of potassium permanganate solution for 34 patients with pemphigus vulgaris served as a control. The main treatment for both groups were glucocorticoids and immune inhibitors. The lesions of patients, bacterial infection, usage of antibiotics, patient's satisfaction, and clinical curative effect were evaluated in the 2 groups...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29559597/efficacy-of-combination-of-ozonated-water-with-oil-for-treatment-of-tinea-pedis
#17
Jianyun Lu, Min Guo, Hongfa Ligui, Kathy Wu, Yaping Xiang, Jinhua Huang, Lihua Gao
To evaluate efficacy of combined therapy with ozonated water and oil on patients with tinea pedis.
 Methods: A total of 60 patients with tinea pedis were divided into 2 groups in a randomized and blinded test. Patients in a control group were treated with naftinfine hydrochloride and ketoconazole cream once a day. Patients in an ozone group were treated with ozonated water bath and then ozonated oil topical application once a day. Patients in the 2 groups were treated for 4 weeks. Clinical and laboratory data were collected for both groups at the end of the 1st week, the 2nd week, and the 4th week...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29559592/emerging-roles-of-ozone-in-skin-diseases
#18
Xiaoqi Wang
Ozone was discovered in the mid-nineteenth century and is proven to have many therapeutic effects, including its common application as a disinfectant to kill microorganisms in various conditions. Ozone therapies have been utilized for various purposes ever since it was discovered. Extensive studies over a century have verified its therapeutic effects, consistency, and safety with minimal and preventable side effects in medical care. Emerging evidence revealed that ozone also plays important roles in the management and prevention of various skin disorders including infectious skin diseases, skin related allergic diseases, erythema scaly diseases, wound healing and ulcer recovery...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29551868/assessment-of-the-effect-of-ozonated-water-irrigation-on-gingival-inflammation-in-patients-undergoing-fixed-orthodontic-treatment
#19
Priya Jose, Biniraj Kannanganatt Ramabhadran, Rishi Emmatty, Tony Pallipurathukaran Paul
Background: A split-mouth longitudinal study was designed here to evaluate the effect of ozonated water delivered subgingivally through a jet device (Kent Ozone dental TY 820 jet) in controlling gingival inflammation of patients undergoing fixed orthodontic therapy. Materials and Methods: Twenty-eight patients undergoing fixed orthodontic treatment following thorough oral prophylaxis were recalled after 2 weeks, and baseline gingival inflammation was estimated. This study was conducted as split-mouth technique with the upper left quadrant (Control side) was irrigated by jetting saline into sulcus by air-water syringe with gauge 22 needle tip and upper right quadrant (Test side) irrigated with ozonated water by a jet device using similar delivery tip...
November 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29536625/ozone-therapy-for-the-treatment-of-chronic-wounds-a-systematic-review
#20
Erin Fitzpatrick, Olivia J Holland, Jessica J Vanderlelie
Chronic wounds present a significant burden to the health care system and the patient. Ozone therapy has been proposed as a treatment for chronic wounds, potentially acting by eliciting mild oxidative stress or disinfection. The purpose of this systematic review is to evaluate the potential benefits and harms of ozone therapy as an advanced care intervention for chronic wounds. Studies were extracted from Google Scholar, PubMed, the Cochrane Library, and reference lists. General inclusion criteria included English-language randomised human trials reporting the use of ozone therapy in the topical treatment of chronic wounds...
March 13, 2018: International Wound Journal
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