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Ozone therapy

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https://www.readbyqxmd.com/read/28228618/preventive-effect-of-intravesical-ozone-supplementation-on-n-methyl-n-nitrosourea-induced-non-muscle-invasive-bladder-cancer-in-male-rats
#1
Kerem Teke, Tayyar A Ozkan, Oguz O Cebeci, Hasan Yilmaz, Muhammed E Keles, Levend Ozkan, Meltem O Dillioglugil, Demir K Yildiz, Ozdal Dillioglugil
Although non-muscle invasive bladder cancer (NMIBC) is widely seen in men, most laboratory studies of new intravesical therapies to prevent NMIBC have been conducted on female animals. In addition, ozone (O3) has been shown to be a beneficial agent as an intravesical application in the treatment of various disorders. In the current study, we evaluated the immunohistopathological oxidative-antioxidative effects of intravesical O3 treatment on n-methyl-n-nitrosourea (MNU)-induced NMIBC. Male Wistar-Albino rats (n=51) were divided into four groups: sham (n=6), O3 only (n=15), MNU only (n=15), and MNU+O3 (n=15)...
February 22, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28216927/intraprostatic-ozone-therapy-a-minimally-invasive-approach-in-benign-prostatic-hyperplasia
#2
Shabbir Hussain, Deepti B Sharma, Fanindra S Solanki, Ajay Pathak, Dhananjay Sharma
INTRODUCTION: Transurethral resection of prostate (TURP) remains the golden standard therapy since decades. There are various minimally invasive therapies (MITs) for the treatment of benign prostatic hyperplasia (BPH). Still, there is a need for therapy with lesser side effects and better outcome. We had studied the effect of intraprostatic ozone injection (IPOI) as an MIT for patients with BPH who have failed trial without catheter (TWOC). MATERIALS AND METHODS: Thirty elderly patients with BPH with a prostate size of 30 g or more were enrolled for the study...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28179287/possible-therapeutic-effects-of-ozone-mixture-on-hypoxia-in-tumor-development
#3
REVIEW
Margherita Luongo, Anna Lisa Brigida, Luigi Mascolo, Gennaro Gaudino
Recent literature highlights that ozone therapy could be considered a viable adjuvant therapy in oncological patients receiving radio-chemotherapy. The use of ozone therapy in these patients enhances the action of chemotherapy and at the same time reduces side-effects, such as nausea, vomiting, opportunistic infections, buccal ulcers, hair loss and fatigue. Such positive therapeutic effects of ozone therapy can cause a larger physical and mental wellbeing resulting in improved quality of life. This work reviews the recent acquisition of scientific knowledge regarding the ozone therapy and highlights the molecular and cellular pathways involved...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28169044/in%C3%A2-vitro-evaluation-of-wound-healing-and-antimicrobial-potential-of-ozone-therapy
#4
Gabriel Álvares Borges, Silvia Taveira Elias, Sandra Márcia Mazutti da Silva, Pérola Oliveira Magalhães, Sergio Bruzadelli Macedo, Ana Paula Dias Ribeiro, Eliete Neves Silva Guerra
Although ozone therapy is extensively applied when wound repair and antimicrobial effect are necessary, little is known about cellular mechanisms regarding this process. Thus, this study aimed to evaluate ozone cytotoxicity in fibroblasts (L929) and keratinocytes (HaCaT) cell lines, its effects on cell migration and its antimicrobial activity. Cells were treated with ozonated phosphate-buffered saline (8, 4, 2, 1, 0.5 and 0.25 μg/mL ozone), chlorhexidine 0.2% or buffered-solution, and cell viability was determined through MTT assay...
March 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28112142/transient-cortical-blindness-after-intradiscal-oxygen-ozone-therapy
#5
Agostino Salvatore Vaiano, Cristiana Valente, Giacomo De Benedetti, Guido Caramello
A 54-year-old caucasian male developed bilateral blindness during an oxygen-ozone injection for disc herniation. The visual loss (VL) was immediately followed by severe frontal headache, vomiting, and nausea. The patient underestimated the VL showing Anton's syndrome, with a complete visual recovery after 2-month follow-up. Magnetic resonance data were consistent with recent ischemic lesions in bilateral vascular territories of posterior cerebral arteries.
December 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28097518/beneficial-effects-of-ozone-therapy-on-oxidative-stress-cardiac-functions-and-clinical-findings-in-patients-with-heart-failure-reduced-ejection-fraction
#6
Mutlu Buyuklu, Fatih Mehmet Kandemir, Turan Set, Eftal Murat Bakırcı, Husnu Degirmenci, Hikmet Hamur, Ergun Topal, Sefa Kucukler, Kultigin Turkmen
The aim of study was to determine the effects of ozone therapy on the oxidative stress, cardiac functions and clinical findings in patients with heart failure reduced ejection fraction (HFrEF). A total of 40 patients with New York Heart Association 2 and 3 HF with left ventricular ejection fraction (LVEF) <35%, and 40 subjects without HF as control group were included in the study. Patients with HFrEF were given additional ozone therapy of major and minor administrations along with conventional HF treatment for 5 weeks...
January 17, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28076466/ozone-therapy-as-an-adjuvant-for-endondontic-protocols-microbiological-ex-vivo-study-and-citotoxicity-analyses
#7
Carlos Goes Nogales, Marina Beloti Ferreira, Antonio Fernando Montemor, Maria Filomena de Andrade Rodrigues, José Luiz Lage-Marques, João Humberto Antoniazzi
Objectives: This study evaluated the antimicrobial efficacy of ozone therapy in teeth contaminated with Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus using a mono-species biofilm model. Parallel to this, the study aimed to evaluate the cytotoxicity of ozone for human gingival fibroblasts. Material and Methods: One hundred and eighty single-root teeth were contaminated with a mono-species biofilm of Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus...
November 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28038382/the-nlrp3-inflammasome-is-a-potential-target-of-ozone-therapy-aiming-to-ease-chronic-renal-inflammation-in-chronic-kidney-disease
#8
Gang Yu, Zhiming Bai, Zhiyuan Chen, Hui Chen, Guoren Wang, Gang Wang, Zhenxiang Liu
Ozone therapy is an effective medical treatment for various diseases. A previous study has demonstrated its reno-protective effect in chronic kidney disease (CKD), but the mechanism involved is not completely known. This study produced the 5/6 nephrectomized CKD rat model and investigated whether the reno-protective effect of ozone therapy was achieved by its anti-inflammatory property through the modulation of the NLRP3 inflammasome. The results showed that ozone therapy at a low concentration improved renal function and ameliorated renal morphological injury in 5/6 nephrectomized rats...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27982260/effect-of-ozone-and-methylprednisolone-treatment-following-crush-type-sciatic-nerve-injury
#9
Omur Ozturk, Aysu Hayriye Tezcan, Yasemen Adali, Can Hakan Yıldırım, Ozgur Aksoy, Hatice Yagmurdur, Ali Bilge
PURPOSE: To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS: Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve: Group I: ozone (20mcg/ml); Group II: methylprednisolone (2mg/kg); Group III: ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV: isotonic saline (0...
November 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27974724/myocardial-infarction-after-ozone-therapy-is-ozone-therapy-dr-jekyll-or-mr-hyde
#10
Çağın Mustafa Üreyen, Cem Yunus Baş, Şakir Arslan
No abstract text is available yet for this article.
December 15, 2016: Cardiology
https://www.readbyqxmd.com/read/27918221/neutrophilic-inflammation-in-asthma-mechanisms-and-therapeutic-considerations
#11
Hun Soo Chang, Tae-Hyeong Lee, Ji Ae Jun, Ae Rin Baek, Jong-Sook Park, So-My Koo, Yang-Ki Kim, Ho Sung Lee, Choon-Sik Park
Neutrophilic airway inflammation represents a pathologically distinct form of asthma and frequently appears in symptomatic adulthood asthmatics. However, clinical impacts and mechanisms of the neutrophilic inflammation have not been thoroughly evaluated up to date. Areas covered: Currently, distinct clinical manifestations, triggers, and molecular mechanisms of the neutrophilic inflammation (namely Toll-like receptor, Th1, Th17, inflammasome) are under investigation in asthma. Furthermore, possible role of the neutrophilic inflammation is being investigated in respect to the airway remodeling...
January 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27894109/ozone-therapy-and-its-use-in-medicine-further-comments
#12
Lamberto Re, Robert Rowen, Valter Travagli
No abstract text is available yet for this article.
November 29, 2016: Cardiology
https://www.readbyqxmd.com/read/27872711/ozone-therapy-could-attenuate-tubulointerstitial-injury-in-adenine-induced-ckd-rats-by-mediating-nrf2-and-nf-%C3%AE%C2%BAb
#13
Gang Yu, Xiuheng Liu, Zhiyuan Chen, Hui Chen, Lei Wang, Zhishun Wang, Tao Qiu, Xiaodong Weng
OBJECTIVES: This study aims to determine the effects of ozone therapy on restoring impaired Nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced CKD. MATERIALS AND METHODS: Sprague-Dawley rats were fed with 0.75% adenine-containing diet to induce CKD and chronic tubulointerstitial injury. Ozone therapy was administered by rectal insufflation. After 4 weeks, serum and kidney samples were collected and analyzed. Renal function and systemic electrolyte level were detected...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27845288/evaluation-of-the-use-of-ozone-therapy-in-treatment-of-inflammatory-processes-in-diabetes-mellitus-in-an-experiment
#14
S Karatieieva, O Yurkiv, S Semenenko, I Kozlovskaya, S Yakobchuk
Studying the effect of ozone therapy on the course of pyoinflammatory processes with diabetes mellitus in the experiment, conducted on 30 white 24-30 month rats, weight 300-450 gr with purulent-inflammatory processes, it was found out that diabetes, which was simulated by subcutaneous injection of alloxan, causes mosaic disturbances of hemostasis system in the presence of pyoinflammatory processes. Complicated changes in blood condition were also detected against the background of diabetes mellitus: chronometric hypocoagulation on the intrinsic pathway of blood coagulation in association with chronometric hypercoagulation by the external thrombinogenesis mechanism and fibrinogenesis depression against the background of hypofibrinogenaemia...
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27771807/effects-of-photodynamic-therapy-2%C3%A2-chlorhexidine-triantibiotic-mixture-propolis-and-ozone-on-root-canals-experimentally-infected-with-enterococcus-faecalis-an-in-vitro-study
#15
Fabio Camacho-Alonso, P Salmerón-Lozano, Y Martínez-Beneyto
The aim of this study was to evaluate the antibacterial effect of photodynamic therapy (PDT), 2 % chlorhexidine (CHX). The teeth were contaminated with 0.1 mL Enterococcus faecalis (3 × 10(8) cell/mL) and randomized into eight treatment groups: Group 1 (2.5 % NaOCl); Group 2 (PDT); Group 3 (2 % CHX); Group 4 (TAM); Group 5 (propolis), Group 6 (ozone), Group 7 (positive control) and Group 8 (negative control). Following treatment, the canal content was sampled. The samples were cultured in triplicate on blood agar plates to determine the number of colony forming units (CFU)/mL...
October 22, 2016: Odontology
https://www.readbyqxmd.com/read/27761743/immunogenic-decapeptide-in-melanoma-immunotherapy
#16
Navnit Kumar Mishra, Anil Kumar Sharma, Tapan Kumar Mukherjee
Melanoma is a cancer associated with melanocytes of epidermis. There has been a consistent increase in the number of melanoma patients because of the depletion of the ozone layer which makes it of paramount importance to explore the immunogenic potential of various peptides in melanoma therapy. In the current study, a mutated decapeptide (ELAGIGILTV) epitope ID 12941 was taken from the melanoma antigen recognized by T-cells. This epitope displayed relatively better affinity for histocompatibility leukocyte antigen influencing the proliferation of cytotoxic T-cells...
November 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27744376/ampk-activation-by-peri-sciatic-nerve-administration-of-ozone-attenuates-cci-induced-neuropathic-pain-in-rats
#17
Lijuan Lu, Cailong Pan, Lu Chen, Liang Hu, Chaoyu Wang, Yuan Han, Yanjing Yang, Zhixiang Cheng, Wen-Tao Liu
Neuropathic pain is a debilitating clinical condition with few efficacious treatments, warranting development of novel therapeutics. Ozone is widely used as an alternative therapy for many different pain conditions, with exact mechanisms still elusive. In this study, we found that a single peri-sciatic nerve injection of ozone decreased mechanical allodynia and thermal hyperalgesia, and normalized the phosphorylation of protein kinase C γ, N-methyl-D-aspartate receptor, and extracellular signal-regulated kinase in a chronic constriction injury (CCI) model in rat sciatic nerve...
October 15, 2016: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/27741414/does-topical-ozone-therapy-improve-patient-comfort-after-surgical-removal-of-impacted-mandibular-third-molar-a-randomized-controlled-trial
#18
Varun P Sivalingam, Elavenil Panneerselvam, Krishnakumar V B Raja, Gayathri Gopi
PURPOSE: To assess the influence of topical ozone administration on patient comfort after third molar surgery. MATERIALS AND METHODS: A single-blinded randomized controlled clinical trial was designed involving patients who required removal of bilateral impacted mandibular third molars. The predictor variable was the postoperative medication used after third molar surgery. Using the split-mouth design, the study group received topical ozone without postoperative systemic antibiotics, whereas the control group did not receive ozone but only systemic antibiotics...
January 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27738434/effectiveness-of-a-short-term-treatment-of-oxygen-ozone-therapy-into-healing-in-a-posttraumatic-wound
#19
Irene Degli Agosti, Elena Ginelli, Bruno Mazzacane, Gabriella Peroni, Sandra Bianco, Fabio Guerriero, Giovanni Ricevuti, Simone Perna, Mariangela Rondanelli
Introduction. A number of studies suggest that oxygen-ozone therapy may have a role in the treatment of chronic, nonhealing, or ischemic wounds for its disinfectant and antibacterial properties. Nonhealing wounds are a significant cause of morbidity. Here we present a case of subcutaneous oxygen-ozone therapy used to treat a nonhealing postoperative wound in a young man during a period of 5 weeks. Case Presentation. A 46-year-old man had a motorcycle accident and underwent amputation of the right tibia and fibula...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27734309/cerebrovascular-pattern-improved-by-ozone-autohemotherapy-an-entropy-based-study-on-multiple-sclerosis-patients
#20
Filippo Molinari, Daniele Rimini, William Liboni, U Rajendra Acharya, Marianno Franzini, Sergio Pandolfi, Giovanni Ricevuti, Francesco Vaiano, Luigi Valdenassi, Vincenzo Simonetti
Ozone major autohemotherapy is effective in reducing the symptoms of multiple sclerosis (MS) patients, but its effects on brain are still not clear. In this work, we have monitored the changes in the cerebrovascular pattern of MS patients and normal subjects during major ozone autohemotherapy by using near-infrared spectroscopy (NIRS) as functional and vascular technique. NIRS signals are analyzed using a combination of time, time-frequency analysis and nonlinear analysis of intrinsic mode function signals obtained from empirical mode decomposition technique...
October 12, 2016: Medical & Biological Engineering & Computing
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