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Ozone therapy

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https://www.readbyqxmd.com/read/29304531/dietary-nitrate-supplementation-reduces-circulating-platelet-derived-extracellular-vesicles-in-coronary-artery-disease-patients-on-clopidogrel-therapy-a-randomised-double-blind-placebo-controlled-study
#1
Nicholas Burnley-Hall, Fairoz Abdul, Vitaliy Androshchuk, Keith Morris, Nick Ossei-Gerning, Richard Anderson, D Aled Rees, Philip E James
Extracellular vesicles (EVs) are implicated in the pathogenesis of cardiovascular disease (CVD). Specifically, platelet-derived EVs are highly pro-coagulant, promoting thrombin generation and fibrin clot formation. Nitrate supplementation exerts beneficial effects in CVD, via an increase in nitric oxide (NO) bioavailability. Clopidogrel is capable of producing NO-donating compounds, such as S-nitrosothiols (RSNO) in the presence of nitrite and low pH. The aim of this study was to assess the effect of nitrate supplementation with versus without clopidogrel therapy on circulating EVs in coronary artery disease (CAD) patients...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29247675/adrenergic-and-glucocorticoid-receptor-antagonists-reduce-ozone-induced-lung-injury-and-inflammation
#2
Andres R Henriquez, Samantha J Snow, Mette C Schladweiler, Colette N Miller, Janice A Dye, Allen D Ledbetter, Judy E Richards, Kevin Mauge-Lewis, Marie A McGee, Urmila P Kodavanti
Recent studies showed that the circulating stress hormones, epinephrine and corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through the activation of the sympathetic-adrenal-medullary (SAM) and hypothalamus-pituitary-adrenal (HPA) axes. Hence, we examined the role of adrenergic and glucocorticoid receptor inhibition in ozone-induced pulmonary injury and inflammation. Male 12-week old Wistar-Kyoto rats were pretreated daily for 7days with propranolol (PROP; a non-selective β adrenergic receptor [AR] antagonist, 10mg/kg, i...
January 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29207120/the-antibacterial-effect-of-topical-ozone-on-the-treatment-of-mrsa-skin-infection
#3
Mingsheng Song, Qinghai Zeng, Yaping Xiang, Lihua Gao, Jian Huang, Jinhua Huang, Kathy Wu, Jianyun Lu
Skin can be infected by many types of microorganisms, most commonly by gram‑positive strains of Staphylococcus and Streptococcus spp. Treatment of Staphylococcus aureus (S. aureus) infections, particularly that of methicillin resistant Staphylococcus aureus (MRSA), is a challenge in clinical practice. Ozone therapy has proven to be one of the strongest antiseptics against the majority of microorganisms involved in skin infections. The purpose of the present study was to evaluate the microbicidal effects of topical ozone therapy on S...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29152215/ozone-therapy-an-overview-of-pharmacodynamics-current-research-and-clinical-utility
#4
REVIEW
Noel L Smith, Anthony L Wilson, Jason Gandhi, Sohrab Vatsia, Sardar Ali Khan
The use of ozone (O3) gas as a therapy in alternative medicine has attracted skepticism due to its unstable molecular structure. However, copious volumes of research have provided evidence that O3's dynamic resonance structures facilitate physiological interactions useful in treating a myriad of pathologies. Specifically, O3 therapy induces moderate oxidative stress when interacting with lipids. This interaction increases endogenous production of antioxidants, local perfusion, and oxygen delivery, as well as enhances immune responses...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29135140/-general-clinical-and-laboratory-and-instrumental-characteristics-of-the-chronic-nonbapterial-prostatite-with-the-inflammatory-component-in-men-of-the-first-period-of-mature-age
#5
Yu Yu Vinnik, V V Borisov
AIM: To investigate the course of CNPIC in young men treated with general and local ozone therapy. MATERIALS AND METHODS: 306 patients underwent standard treatment concurrently with local and systemic ozone therapy. Clinical-laboratory and instrumental parameters were evaluated before and after treatment. In addition, the blood flow of the prostate, prostatic urethra and skin at the projection point of the prostate was studied. RESULTS: Standard treatment of CNPIC with the concurrent use of general and local ozone therapy resulted in a reduction of pain intensity and severity of dysuria, improvement of the sexual function and quality of life of men...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29124710/ultraviolet-irradiation-of-blood-the-cure-that-time-forgot
#6
Michael R Hamblin
Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However with the development of antibiotics, UBI use declined and it has now been called "the cure that time forgot". Later studies were mostly performed by Russian workers and in other Eastern countries and the modern view in Western countries is that UBI remains highly controversial...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29119959/-the-potential-of-the-non-pharmacological-methods-for-the-rehabilitation-and-prophylaxis-in-the-patients-suffering-from-with-atopic-dermatitis
#7
I V Kosheleva, O A Bitkina, N A Klivitskaya, L I Shadyzheva
This article was designed to discuss the therapeutic potential of various non-pharmacological and physiotherapeutic methods for the treatment and rehabilitation of the patients presenting with atopic dermatitis (AD) during the inter-recurrence period of the disease. The particular emphasis is placed on the physical agents most frequently used for the purpose with special reference to the combined therapy of atopic dermatitis in the adults and children and to their rehabilitation in the inter-exacerbation periods...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29119958/-the-experience-with-the-application-of-ozone-therapy-for-the-treatment-of-periodontitis-in-musicians-instrumentalists
#8
A V Kislitsyna, A G Volkov, N Zh Dikopova, S S Akhmedbaeva, A L Shishmareva
Playing various musical instruments is the cause of an additional load that affects the condition of dentition and of all organs and body systems at large. Each group of instruments is known to exert a specific impact on the health of the musicians including the undesirable influence on the state of thir oral cavity, such as a change of occlusion and irritation of oral mucosa. Taken together, these effects contribute to the development of periodontal disease, one of the most common dental disorders. AIM: The objective of the present study was to evaluate the effectiveness of ozone therapy conducted with the use of the generator producing ozone under effect of ultraviolet radiation for the treatment of periodontitis in musicians-instrumentalists...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29065815/management-of-pain-in-tmd-patients-bio-oxidative-ozone-therapy-versus-occlusal-splints
#9
Tamer Celakil, Almina Muric, Bilge Gökcen Roehlig, Gulumser Evlioglu
OBJECTIVE: To compare the effects of bio-oxidative ozone application with occlusal splints in temporomandibular disorder (TMD) patients with pain. METHODS: Forty participants were selected after the diagnosis of TMD and randomly divided into two groups: ozone group (OG, n = 20) and occlusal splint group (OCSG, n = 20). Ozone was applied to patients three times per week, for a total of six sessions. Patients in the OCSG were instructed to use occlusal splints every night over a period of four weeks...
October 24, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/29039154/severe-headache-following-ozone-therapy-pneumocephalus
#10
Hüseyin Toman, Uğur Özdemir, Hasan Ali Kiraz, Nurettin Lüleci
Pneumocephalus is defined as air in the cranial cavity. Pneumocephalus can result from inadvertent dural puncture during lumbar epidural anesthesia or epidural steroid injection. Presently described is case of 41-year-old woman who had undergone lumbar disc hernia operation but due to ongoing complaints, was diagnosed as having failed back surgery syndrome. Percutaneous epidural neuroplasty was performed. In the operating room, under sterile conditions and under sedoanalgesia, Racz catheter was inserted in caudal area and guided to epidural area with scope...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29022413/moderate-o3-o2-therapy-enhances-enzymatic-and-non-enzymatic-antioxidant-in-brain-and-cochlear-that-protects-noise-induced-hearing-loss
#11
Parvaneh Nasezadeh, Farshad Shahi, Mohammadjavad Fridoni, Enayatollah Seydi, Morteza Izadi, Ahmad Salimi
Mitochondrial damage and oxidative stress are known to contribute to the pathogenesis of noise-induced hearing loss (NIHL). In this study, we examined the protective effect of O2/O3 mixture (ozone/oxygen) therapy against mitochondrial induced damage and oxidative stress by noise exposure in rat brain and cochlear. For this purpose, rats were divided into four groups: 1 - control group; 2 - noise-exposed group (100 dB); 3 - noise + O2/O3, and 4 - O2/O3 (30 µg/ml). After 14 d, animals were anesthetised...
October 2017: Free Radical Research
https://www.readbyqxmd.com/read/28968031/-effect-of-combined-application-of-ozone-therapy-and-gravitational-therapy-on-the-remote-results-of-complex-treatment-of-geriatric-patients
#12
I V Makarov, Yu V Shchukin, A V Lukashova
The article presents the remote results of treatment of an obliterating atherosclerosis of arteries of the lower extremities of the II stage at patients of advanced and senile age after the combined use of ozone therapy and gravitational therapy. We performed a prospective randomized study in three parallel groups (139 patients). The 1st group (n=57) received standard medical therapy in combination with ozone therapy; the group was divided into two subgroups: for patients of subgroup 1a (n=28) - intravenous ozonized physiological solution was performed, for patients of subgroup 1b (n=29) - major ozonized autohemotherapy...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28911970/mesenchymal-stem-cells-alleviate-oxidative-stress-induced-mitochondrial-dysfunction-in-the-airways
#13
Xiang Li, Charalambos Michaeloudes, Yuelin Zhang, Coen H Wiegman, Ian M Adcock, Qizhou Lian, Judith C W Mak, Pankaj K Bhavsar, Kian Fan Chung
BACKGROUND: Oxidative stress-induced mitochondrial dysfunction can contribute to inflammation and remodeling in patients with chronic obstructive pulmonary disease (COPD). Mesenchymal stem cells protect against lung damage in animal models of COPD. It is unknown whether these effects occur through attenuating mitochondrial dysfunction in airway cells. OBJECTIVE: We sought to examine the effect of induced pluripotent stem cell-derived mesenchymal stem cells (iPSC-MSCs) on oxidative stress-induce mitochondrial dysfunction in human airway smooth muscle cells (ASMCs) in vitro and in mouse lungs in vivo...
September 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28872147/generation-of-a-chronic-obstructive-pulmonary-disease-model-in-mice-by-repeated-ozone-exposure
#14
Zhongwei Sun, Feng Li, Xin Zhou, Wen Wang
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung parenchymal destruction. It has a very high incidence in aging populations. The current conventional therapies for COPD focus mainly on symptom-modifying drugs; thus, the development of new therapies is urgently needed. Qualified animal models of COPD could help to characterize the underlying mechanisms and can be used for new drug screening. Current COPD models, such as lipopolysaccharide (LPS) or the porcine pancreatic elastase (PPE)-induced emphysema model, generate COPD-like lesions in the lungs and airways but do not otherwise resemble the pathogenesis of human COPD...
August 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28860878/ozonated-autohemotherapy-modulates-the-serum-levels-of-inflammatory-cytokines-in-gouty-patients
#15
Lian-Yun Li, Ruo-Lan Ma, Liqin Du, An-Shi Wu
OBJECTIVES: Ozonated autohemotherapy (O3-AHT) has been used to effectively treat gout, but the underlying therapeutic mechanisms remain unknown. In this study, as an initial effort to understand the therapeutic mechanisms of O3-AHT, we aim to examine the effect of O3-AHT on serum inflammatory cytokine levels in gouty patients. PATIENTS AND METHODS: Three groups of patients and healthy subjects were recruited, including the gouty (n=10), hyperuricemia (n=10), and healthy control (n=11) groups...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28858272/-assessment-of-antibacterial-efficacy-of-ozone-therapy-in-treatment-of-caries-at-the-white-spot-stage
#16
I M Makeeva, A Yu Turkina, E G Margaryan, Yu O Paramonov, M A Polyakova
Effect on cariogenic flora is the key toremineralizing therapy efficacy in treatment of initial caries (at the white spot stage). Ozone in dentistry is used as a highly effective antibacterial agent. Treatment of white spot lesions with the ozone-air mixture leads to significant increase of efficacy in non-invasive treatment of initial caries. OBJECTIVE: clinical and microbiological assessment of antibacterial efficacy of ozone therapy in treatment of caries at the white spot stage. MATERIAL AND METHODS: The trial recruited 86 patients for non-invasive treatment of caries at the white spot stage which included the complex of professional oral hygiene, medicamental treatment of white spot lesions with hydrogen peroxide 3% and chlorhexidinedigluconate 0,2%, treatment with the ozone-air mixture and application of hydroxyapatite Са2+...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28853025/is-there-a-place-for-ozone-therapy-in-patients-with-heart-failure
#17
Bernardino Clavo, Khaled Eltobgy, Eduardo Caballero, Cipriano Abad, Francisco Rodríguez-Esparragón, Norberto Santana-Rodríguez
No abstract text is available yet for this article.
October 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28834388/dry-eye-disease-and-oxidative-stress
#18
REVIEW
Sophia Seen, Louis Tong
Dry eye, an age-related condition, is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability. Environmental factors are also often implicated in dry eye including exposure to pollutants, ultraviolet (UV) radiation and ozone as well as the chronic use of preserved eyedrops such as in the treatment of glaucoma. These factors increase oxidative stress and ocular surface inflammation. Here, we reviewed the cellular, animal and clinical studies that point to the role of oxidative stress in dry eye disease...
August 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28807098/protective-effect-of-ozone-against-hemiscorpius-lepturus-envenomation-in-mice
#19
Parvaneh Naserzadeh, Farshad Shahi, Delavar Shahbazzadeh, Mostafa Ghanei, Khadijeh Ashtari, Yoones Panahi, Mir-Jamal Hosseini, Morteza Izadi
OBJECTIVE: Scorpion (Hemiscorpius lepturus) stings are a public health concern in Iran, particularly in south and southwestern regions of Iran. The gold standard for the treatment of a scorpion sting is anti-venom therapy. However, immunotherapy can have serious side effects, such as anaphylactic shock (which can sometimes even lead to death). The aim of the current study was to demonstrate the protective effect of ozone against toxicity induced by Hemiscorpius lepturus (H. lepturus) venom in mice...
August 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28727712/intervertebral-foramen-injection-of-ozone-relieves-mechanical-allodynia-and-enhances-analgesic-effect-of-gabapentin-in-animal-model-of-neuropathic-pain
#20
Wen-Jun Luo, Fan Yang, Fei Yang, Wei Sun, Wei Zheng, Xiao-Liang Wang, Fang-Fang Wu, Jiang-Lin Wang, Jia-Shuang Wang, Su-Min Guan, Jun Chen
BACKGROUND: In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life. However, so far no proof-of-concept studies in animals have been available. OBJECTIVE: This study was designed to investigate whether IVF ozone has an analgesic effect on animal models of neuropathic and inflammatory pain...
July 2017: Pain Physician
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