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https://www.readbyqxmd.com/read/29907273/extracorporeal-gas-exchange
#1
REVIEW
Onnen Moerer, Francesco Vasques, Eleonora Duscio, Francesco Cipulli, Federica Romitti, Luciano Gattinoni, Michael Quintel
Extracorporeal gas exchange is increasingly used for various indications. Among these are refractory acute respiratory failure, including the acute respiratory distress syndrome (ARDS), and the avoidance of ventilator-induced lung injury (VILI) by enabling lung-protective ventilation. Additionally, extracorporeal gas exchange allows the treatment of hypercapnic respiratory failure while helping to unload the respiratory muscles and avoid intubation and invasive ventilation, as well as facilitating weaning from the ventilator...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907269/determinants-and-prevention-of-ventilator-induced-lung-injury
#2
REVIEW
Francesco Vasques, Eleonora Duscio, Francesco Cipulli, Federica Romitti, Michael Quintel, Luciano Gattinoni
Ventilator-induced lung injury develops from interactions between the lung parenchyma and applied mechanical power. In acute respiratory distress syndrome, the lung is smaller size with an inhomogeneous structure. The same mechanical force applied on a reduced parenchyma would produce volutrauma; the concentration of mechanical forces at inhomogeneous interfaces produces atelectrauma. Higher positive end-expiratory pressures favor volutrauma and reduce atelectrauma; lower values do the opposite. Volutrauma and atelectrauma harms and benefits, however, seem to be equivalent at 5 to 15 cm H2 O...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907148/a-case-of-metaplastic-atrophic-gastritis-in-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-ipex-syndrome
#3
Youyou Luo, Jie Chen, Youhong Fang, Jingan Lou, Jindan Yu
BACKGROUND: Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia and carcinoma. It is rare in paediatric cohorts. CASE PRESENTATION: We present the case of a boy with metaplastic atrophic gastritis in whom immune dysregulation, polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome was confirmed by FOXP3 gene mutation...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29907087/factors-associated-with-missed-assessments-in-a-2-year-longitudinal-study-of-acute-respiratory-distress-syndrome-survivors
#4
Sara E Heins, Amy W Wozniak, Elizabeth Colantuoni, Kristin A Sepulveda, Pedro A Mendez-Tellez, Cheryl Dennison-Himmelfarb, Dale M Needham, Victor D Dinglas
BACKGROUND: To evaluate participant-related variables associated with missing assessment(s) at follow-up visits during a longitudinal research study. METHODS: This is a prospective, longitudinal, multi-site study of 196 acute respiratory distress syndrome (ARDS) survivors. More than 30 relevant sociodemographic, physical status, and mental health variables (representing participant characteristics prior to ARDS, at hospital discharge, and at the immediately preceding follow-up visit) were evaluated for association with missed assessments at 3, 6, 12, and 24-month follow-up visits (89-95% retention rates), using binomial logistic regression...
June 15, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29905558/urinary-malondialdehyde-as-a-predictive-and-diagnostic-marker-for-neonatal-acute-kidney-injury
#5
Y Hodovanets, A Babintseva, L Agafonova, O Makarova, A Frunza
Newborns are especially prone to oxidative stress (OS). Many free radical-mediated diseases have been described in newborns including bronchopulmonary dysplasia, respiratory distress syndrome, encephalopathy, and kidney injury. Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns. 67 critically sick full-term neonates were enrolled in the study including 31 newborns with AKI (group I) and 36 newborns without AKI (group II)...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904601/incidence-and-risk-factors-for-complications-after-definitive-skeletal-fixation-of-lower-extremity-in-multiple-injury-patients-a-retrospective-chart-review
#6
Thananit Sangkomkamhang, Wilaiphorn Thinkhamrop, Bandit Thinkhamrop, Wongsa Laohasiriwong
Background : The management of multiple injuries is complex. Type and timing of treatment for lower extremity fractures is a controversial subject. Although many studies have demonstrated the safety and effectiveness of early treatment, others have suggested that early definitive stabilization may cause complications, especially with chest and head injuries. The aim of this study was to determine the complications and effects of timing of fixation, and investigate risk factors for complications in multiple injuries patients with lower extremity fractures...
2018: F1000Research
https://www.readbyqxmd.com/read/29904430/expression-profile-of-micrornas-following-bone-marrow-derived-mesenchymal-stem-cell-treatment-in-lipopolysaccharide-induced-acute-lung-injury
#7
Joonhong Park, Sikyoung Jeong, Kicheol Park, Keumjin Yang, Soyoung Shin
Immunomodulatory or immunosuppressive properties of bone marrow-derived mesenchymal stem cells (BM-MSCs) facilitate the treatment of acute respiratory distress syndrome and acute lung injury (ALI). Dysregulated miRNA (miRNA or miR) expression associated with the effects of BM-MSCs was assessed in a rat model of lipopolysaccharide (LPS)-induced ALI. The present study performed biochemical tests to assess five analytes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, blood urea nitrogen (BUN), and creatinine (CREA)...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904039/an-unusual-cause-of-cauda-equina-syndrome-lumbar-epidural-venous-engorgement
#8
Husam A AlTahan, Roaa R Amer, Areej A Madani, Eman A Bakhsh
BACKGROUND Epidural venous plexus (EVP) engorgement occurs due to many conditions, so it can be easily misdiagnosed. This becomes problematic when the diagnosis requires prompt treatment for a good outcome, especially when it results in cauda equina syndrome (CES). We report a case of extensive iliocaval thrombosis leading to epidural venous plexus and ascending lumbar vein engorgement as an outcome of deep venous thrombosis (DVT) due to probable adverse effects of oral combined contraceptive pills (OCCP). CASE REPORT A 42-year-old woman presented to a rural medical facility with bilateral lower-limb swelling and skin darkening for 2 days...
June 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29903755/severity-scoring-of-lung-oedema-on-the-chest-radiograph-is-associated-with-clinical-outcomes-in-ards
#9
Melissa A Warren, Zhiguou Zhao, Tatsuki Koyama, Julie A Bastarache, Ciara M Shaver, Matthew W Semler, Todd W Rice, Michael A Matthay, Carolyn S Calfee, Lorraine B Ware
BACKGROUND: There is no accurate, non-invasive measurement to estimate the degree of pulmonary oedema in acute respiratory distress syndrome (ARDS). We developed the Radiographic Assessment of Lung Oedema (RALE) score to evaluate the extent and density of alveolar opacities on chest radiographs. After first comparing the RALE score to gravimetric assessment of pulmonary oedema in organ donors, we then evaluated the RALE score in patients with ARDS for its relationship to oxygenation and clinical outcomes...
June 14, 2018: Thorax
https://www.readbyqxmd.com/read/29903600/revisiting-extracorporeal-membrane-oxygenation-for-ards-in-burns-a-case-series-and-review-of-the-literature
#10
Craig R Ainsworth, Jeffrey Dellavolpe, Kevin K Chung, Leopoldo C Cancio, Phillip Mason
INTRODUCTION: Recent reports on the use of extracorporeal membrane oxygenation (ECMO) in critically ill burn patients with Acute Respiratory Distress Syndrome (ARDS) recommended against the use of ECMO. The authors cited the high mortality rates associated with the use of ECMO in these patients with no appreciable benefit. Accumulating evidence from referral centers suggests improved survival in patients with ARDS receiving ECMO. We report our recent experience treating patients with severe ARDS with ECMO in a burn intensive care unit...
June 11, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29901798/the-use-of-extracorporeal-membrane-oxygenation-for-acute-respiratory-distress-syndrome-in-severe-burns-without-inhalation-injury
#11
Juliet J Ray, Richard J Straker, Valerie J Hart, Jonathan P Meizoso, Carl I Schulman, Matthias Loebe, Ali Ghodsizad
Burn injury results in a severe systemic inflammatory response which is associated with the development of acute respiratory distress syndrome (ARDS), even without associated inhalation injury. Venous-venous extracorporeal membrane oxygenation (VV-ECMO) has been implemented in various cases of ARDS to provide support and allow for protective lung ventilation strategies. We report the case of a 27-year-old man presenting with a 60% total body surface area partial thickness burn who developed refractory ARDS with Murray Score of 3...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29901573/acute-scoliosis-as-an-unusual-presentation-of-pneumonia-a-case-report
#12
Rajan Atwal, Charles Stewart
We describe the unique case of a child with pneumonia presenting with acute scoliosis and abdominal pain, without any typical features of the disease.A 10-year-old girl presented to the emergency department on 3 consecutive days with right-sided abdominal pain. There were no associated features, in particular, no fevers or respiratory symptoms. On the first 2 presentations, observation,examination, and blood test findings were unremarkable. Chest x-ray and abdominal ultrasound were also normal. On the third presentation a marked scoliosis was noted and abdominal examination revealed right-sided tenderness with rebound...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898577/nonpulmonary-risk-factors-of-acute-respiratory-distress-syndrome-in-patients-with-septic-bacteraemia
#13
Hyunseung Nam, Seung Hun Jang, Yong Il Hwang, Joo-Hee Kim, Ji Young Park, Sunghoon Park
Background/Aims: The relationship between nonpulmonary organ failure and the development of acute respiratory distress syndrome (ARDS) in patients with sepsis has not been well studied. Methods: We retrospectively reviewed the medical records of patients with septic bacteremia admitted to the medical intensive care unit (ICU) of a tertiary academic hospital between January 2013 and December 2016. Results: The study enrolled 125 patients of median age 73...
June 14, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29898428/acute-respiratory-distress-syndrome-without-identifiable-risk-factors-a-secondary-analysis-of-the-ards-network-trials
#14
John S Harrington, Edward J Schenck, Clara Oromendia, Augustine M K Choi, Ilias I Siempos
PURPOSE: We examined whether patients with acute respiratory distress syndrome (ARDS) lacking risk factors are enrolled in therapeutic trials and assessed their clinical characteristics and outcomes. METHODS: We performed a secondary analysis of patient-level data pooled from the ARMA, ALVEOLI, FACTT, ALTA and EDEN ARDSNet randomized controlled trials obtained from the Biologic Specimen and Data Repository Information Coordinating Center of the National Heart, Lung and Blood Institute...
June 2, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29898376/a2bar-activation-attenuates-acute-lung-injury-by-inhibiting-alveolar-epithelial-cell-apoptosis-both-in-vivo-and-in-vitro
#15
Xiaotao Xu, Qingwei Zhu, Fangfang Niu, Rong Zhang, Yan Wang, Wenying Wang, Dawei Sun, Xintao Wang, Aizhong Wang
The epithelial barrier of the lung is destroyed during acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) due to the apoptosis of alveolar epithelial cells (AECs). Therefore, treatments that block AEC apoptosis might be a therapeutic strategy to ameliorate ALI. Based on recent evidence, A2B adenosine receptor (A2BAR) plays an important role in ALI in several different animal models, but its exact function in AECs has not been clarified. We investigated the role of A2BAR in AEC apoptosis in a mouse model of oleic acid (OA)-induced ALI and in hydrogen peroxide (H2 O2 )-induced AEC (A549 cells and MLE-12 cells) injury...
June 13, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29895331/immunocompromised-patients-with-acute-respiratory-distress-syndrome-secondary-analysis-of-the-lung-safe-database
#16
Andrea Cortegiani, Fabiana Madotto, Cesare Gregoretti, Giacomo Bellani, John G Laffey, Tai Pham, Frank Van Haren, Antonino Giarratano, Massimo Antonelli, Antonio Pesenti, Giacomo Grasselli
BACKGROUND: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. METHODS: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents...
June 12, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29890216/apigenin-c-glycosides-of-microcos-paniculata-protects-lipopolysaccharide-induced-apoptosis-and-inflammation-in-acute-lung-injury-through-tlr4-signaling-pathway
#17
Kunping Li, Zhuoru He, Xinqiuyue Wang, Miguel Pineda, Runbao Chen, Haiqi Liu, Kaiting Ma, Huanjia Shen, Chunhui Wu, Ningtin Huang, Tianling Pan, Yun Liu, Jiao Guo
Acute lung injury (ALI) and its more severe form acute respiratory distress syndrome (ARDS) are life-threatening conditions with high morbility and mortality, underscoring the urgent need for novel treatments. Leaves of the medicinal herb Microcos paniculata have been traditionally used for treating upper airway infections, by virtue of its content of flavonoids such as apigenin C-glycosides (ACGs). C-glycosides have been shown to exert strong anti-inflammatory properties, although their mechanism of action remains unknown...
June 8, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29886847/cytomegalovirus-reactivation-in-a-critically-ill-patient-a-case-report
#18
Demet Demirkol, Umay Kavgacı, Burcu Babaoğlu, Serhan Tanju, Banu Oflaz Sözmen, Suda Tekin
BACKGROUND: The aim of this case report is to discuss diagnostic workup and clinical management of cytomegalovirus reactivation in a critically ill immunocompetent pediatric patient. CASE PRESENTATION: A 2-year-old white boy who had no medical history presented with respiratory distress and fever. His Pediatric Risk of Mortality and Pediatric Logistic Organ Dysfunction scores were 20 and 11, respectively. Our preliminary diagnosis was multiple organ dysfunction secondary to sepsis...
June 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29886120/acute-respiratory-distress-syndrome-and-plasmodium-ovale-malaria
#19
Brice Guerpillon, André Boibieux, Thomas Perpoint, Bernard Allaouchiche, Martine Wallon
No abstract text is available yet for this article.
June 7, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29886117/the-abbreviated-burn-severity-index-as-a-predictor-of-acute-respiratory-distress-syndrome-in-young-individuals-with-severe-flammable-starch-based-powder-burn
#20
Kuan-Hsun Lin, Chi-Ming Chu, Yu-Kai Lin, Hao-Yu Chiao, Ta-Wei Pu, Yuan-Ming Tsai, Ying-Yi Chen, Hsu-Kai Huang, Hung Chang, Shih-Chun Lee, Tsai-Wang Huang
Here, we investigated whether the abbreviated burn severity index (ABSI) scoring system predicts acute respiratory distress syndrome (ARDS) in a retrospective analysis of a severe flammable starch-based powder burn population. Demographics, total body surface area (TBSA) burn, the presence of mouth and nose burn, ABSI, inhalation injury, and clinical outcomes for each patient were analysed for association with inpatient ARDS based on the Berlin definition. We treated 53 patients (64% male, 36% female) and observed no fatalities...
June 6, 2018: Burns: Journal of the International Society for Burn Injuries
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