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https://www.readbyqxmd.com/read/29143714/new-insights-into-mitogenomic-phylogeny-and-copy-number-in-eight-indigenous-sheep-populations-based-on-the-atp-synthase-and-cytochrome-c-oxidase-genes
#1
P Xiao, L L Niu, Q J Zhao, X Y Chen, L J Wang, L Li, H P Zhang, J Z Guo, H Y Xu, T Zhong
The origins and phylogeny of different sheep breeds has been widely studied using polymorphisms within the mitochondrial hypervariable region. However, little is known about the mitochondrial DNA (mtDNA) content and phylogeny based on mtDNA protein-coding genes. In this study, we assessed the phylogeny and copy number of the mtDNA in eight indigenous (population size, n=184) and three introduced (n=66) sheep breeds in China based on five mitochondrial coding genes (COX1, COX2, ATP8, ATP6 and COX3). The mean haplotype and nucleotide diversities were 0...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29141006/the-mitochondrial-genome-of-muga-silkworm-antheraea-assamensis-and-its-comparative-analysis-with-other-lepidopteran-insects
#2
Deepika Singh, Debajyoti Kabiraj, Pragya Sharma, Hasnahana Chetia, Ponnala Vimal Mosahari, Kartik Neog, Utpal Bora
Muga (Antheraea assamensis) is an economically important silkmoth endemic to the states of Assam and Meghalaya in India and is the producer of the strongest known commercial silk. However, there is a scarcity of genomic and proteomic data for understanding the organism at a molecular level. Our present study is on decoding the complete mitochondrial genome (mitogenome) of A. assamensis using next generation sequencing technology and comparing it with other available lepidopteran mitogenomes. Mitogenome of A...
2017: PloS One
https://www.readbyqxmd.com/read/29138618/diversity-phylogeny-and-host-specialization-of-hyaloperonospora-species-in-korea
#3
Jae Sung Lee, Hyang Burm Lee, Hyeon-Dong Shin, Young-Joon Choi
The genus Hyaloperonospora (Peronosporaceae; Oomycota) is an obligate biotrophic group that causes downy mildew disease on the Brassicaceae and allied families of Brassicales, including many economically relevant crops, such as broccoli, cabbage, radish, rape, and wasabi. To investigate the diversity of Hyaloperonospora species in northeast Asia, we performed a morphological analysis for the dried herbarium specimens collected in Korea, along with molecular phylogenetic inferences based on internal transcribed spacer rDNA and cox2 mtDNA sequences...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29137154/two-sulfur-glycoside-compounds-isolated-from-lepidium-apetalum-willd-protect-nrk52e-cells-against-hypertonic-induced-adhesion-and-inflammation-by-suppressing-the-mapk-signaling-pathway-and-raas
#4
Peipei Yuan, Xiaoke Zheng, Meng Li, Yingying Ke, Yang Fu, Qi Zhang, Xiaolan Wang, Weisheng Feng
Lepidium apetalum Willd has been used to reduce edema and promote urination. Cis-desulfoglucotropaeolin (cis-DG) and trans-desulfoglucotropaeolin (trans-DG) were isolated from Lepidium apetalum Willd, and caused a significant increase in cell viability in a hypertonic model in NRK52e cells. In the hypertonic model, cis-DG and trans-DG significantly promoted the cell viability of NRK52e cells and inhibited the elevation of Na⁺ in the supernatant, inhibited the renin-angiotensin-aldosterone (RAAS) system, significantly reduced the levels of angiotensin II (Ang II) and aldosterone (ALD), and lowered aquaporin-2 (AQP2) and Na⁺-K⁺ ATP content in renal medulla...
November 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29135040/the-suppressive-effects-of-geniposide-and-genipin-on-helicobacter-pylori-infections-in-vitro-and-in-vivo
#5
Chiung-Hung Chang, Jin-Bin Wu, Jai-Sing Yang, Yen-Ju Lai, Chiu-Hsian Su, Chi-Cheng Lu, Yuan-Man Hsu
Geniposide and genipin have been found in Gardenia jasminoides Ellis, a traditional Chinese medicine that exhibits multiple biological functions. However, no report showing the effects of geniposide and genipin on gastric protection in Helicobacter pylori infections in vitro and in vivo has been done. In this study, we clarified how geniposide and genipin suppress H. pylori-mediated inflammation in gastric AGS cells and C57BL/6 mice. Our results demonstrated that genipin shows a strong ability to inhibit H...
November 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29132131/il-6-promotes-fsh-induced-vegf-expression-through-jak-stat3-signaling-pathway-in-bovine-granulosa-cells
#6
Meng Yang, Lei Wang, Xurong Wang, Xuezhi Wang, Zhiqiang Yang, Jianxi Li
BACKGROUND/AIMS: Vascular endothelial growth factor (VEGF) has been demonstrated to play a pivotal role in the regulation of angiogenesis in ovarian follicular development, particularly during the preovulatory period. Although numerous studies have shown that interleukin-6 (IL-6) is one of the major inducing factors that regulate the expression of VEGF in non-ovarian cells, whether it involved in regulating the expression of VEGF in normal ovarian granulosa cells is still unknown. The aim of this study was to elucidate the mechanisms underlying the effect of IL-6 on FSH-induced VEGF expression in bovine granulosa cells derived from large follicles...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29118653/a-combined-human-case-of-dirofilaria-ursi-infection-in-dorsal-subcutaneous-tissue-and-anisakis-simplex-sensu-stricto-s-s-infection-in-ventral-subcutaneous-tissue
#7
Minoru Yamada, Namiko Shishito, Yoshihiro Nozawa, Shigehiko Uni, Keisuke Nishioka, Takaaki Nakaya
Background: Dirofilaria ursi is a filarial nematode that parasitizes the subcutaneous tissues of the American black bear (Ursus americanus) and Japanese black bear (Ursus thiabetanus japonicus). D. ursi that has parasitized black bears has the potential to subsequently infect humans. In addition, extra-gastrointestinal anisakiasis is less common in Japan. Case presentation: We report a case of ventral subcutaneous anisakiasis and dorsal subcutaneous dirofilariasis that was acquired in Fukushima, in the northern part of Japan...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29117751/phenotypic-and-mtdna-variation-in-philippine-kappaphycus-cottonii-gigartinales-rhodophyta
#8
Richard V Dumilag, William George M Gallardo, Christian Philip C Garcia, YeaEun You, Alyssa Keren G Chaves, Lance Agahan
Members of the carrageenan-producing seaweeds of the genus Kappapphycus have a complicated taxonomic history particularly with regard to species identification. Many taxonomic challenges in this group have been currently addressed with the use of mtDNA sequences. The phylogenetic status and genetic diversity of one of the lesser known species, Kappaphycus cottonii, have repeatedly come into question. This study explored the genetic variation in Philippine K. cottonii using the mtDNA COI-5P gene and cox2-3 spacer sequences...
November 9, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29116460/potential-usefulness-of-methyl-gallate-in-the-treatment-of-experimental-colitis
#9
María Laura Anzoise, Angeles Rodríguez Basso, Julieta Sofía Del Mauro, Andrea Carranza, Graciela López Ordieres, Susana Gorzalczany
Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental colitis was induced in Sprague-Dawley rats through the intracolonic instillation of an acetic acid solution (2 mL, 4% v/v). Methyl gallate (100 and 300 mg/kg, p.o.) and the reference drug mesalazine (100 mg/kg, p...
November 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29116428/bromoethylindole-bei-9-redirects-nf-%C3%AE%C2%BAb-signaling-induced-by-camptothecin-and-tnf%C3%AE-to-promote-cell-death-in-colon-cancer-cells
#10
Rupak Chowdhury, Dominique Gales, Paloma Valenzuela, Sonni Miller, Teshome Yehualaeshet, Upender Manne, Giulio Francia, Temesgen Samuel
Chemotherapeutic regimens containing camptothecin (CPT), 5-fluorouracil, and oxaliplatin are used to treat advanced colorectal cancer. We previously reported that an indole derivative, 3-(2-bromoethyl)indole (BEI-9), inhibited the proliferation of colon cancer cells and suppressed NF-κB activation. Here, we show that a combination of BEI-9 with either CPT or tumor necrosis factor alpha (TNFα) enhances cell death. Using colorectal cancer cells, we examined the activation of NF-κB by drugs, the potential of BEI-9 for inhibiting drug-induced NF-κB activation, and the enhancement of cell death by combination treatments...
November 8, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29114165/a-second-locality-for-the-namib-darkling-beetle-onymacris-brainei-tenebrionidae-coleoptera-and-first-report-on-its-molecular-phylogenetic-placement
#11
Trip Lamb, Eugene Marais, Jason E Bond
Onymacris brainei Penrith, 1984 - the most recent species of Onymacris to be described - is known only from its type locality in the Namib Desert, adjacent to the Cunene River in northern Namibia. No additional specimens are known to have been collected beyond the type series. Herein, we report on eight specimens discovered at a second site near the original locality. DNA from four beetles was used to determine the phylogenetic placement of O. brainei among congeners, based on sequence data from one nuclear (histone III) and two mitochondrial (cox1, cox2) genes...
2017: ZooKeys
https://www.readbyqxmd.com/read/29113666/predictive-biomarkers-for-response-of-esophageal-cancer-to-chemo-radio-therapy-a-systematic-review-and-meta-analysis
#12
REVIEW
Yang Li, He-Cheng Huang, Long-Qi Chen, Li-Yan Xu, En-Min Li, Jian-Jun Zhang
BACKGROUND: Esophageal cancer remains a major public health issue worldwide. In clinical practice, chemo(radio)therapy is an important approach to patients with esophageal cancer. Only the part of patients who respond to chemo(radio)therapy achieve better long-term outcome. In this case, predictive biomarkers for response of esophageal cancer patients treated with chemo(radio)therapy are of importance. Meta-analysis of P53 for predicting esophageal cancer response has been reported before and is not included in our study...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29109190/trpv4-transient-receptor-potential-vanilloid-4-mediates-endothelium-dependent-contractions-in-the-aortae-of-hypertensive-mice
#13
Peng Zhang, Chunyuan Sun, Hongjuan Li, Chunlei Tang, Hao Kan, Zhenyu Yang, Aiqin Mao, Xin Ma
The role of TRPV4 (transient receptor potential vanilloid 4) in regulating vascular contraction in hypertensive mice is poorly established. We tested the hypothesis that TRPV4 regulates endothelium-dependent contractions in aortae from hypertensive mice through the activation of cytosolic cPLA2 (phospholipase A2) and COX2 (cyclooxygenase 2) and identified the possible endothelium-derived contracting factor generated by COX2. Using myography, we demonstrated that GSK1016790A (a TRPV4 agonist) and acetylcholine (ACh) trigger endothelium-dependent contractions in aortae from hypertensive mice, and the contractions were abolished with TRPV4 deletion...
November 6, 2017: Hypertension
https://www.readbyqxmd.com/read/29109117/chemoprevention-with-cyclooxygenase-and-epidermal-growth-factor-receptor-inhibitors-in-familial-adenomatous-polyposis-patients-mrna-signatures-of-duodenal-neoplasia
#14
Don A Delker, Austin C Wood, Angela K Snow, N Jewel Samadder, Wade S Samowitz, Kajsa E Affolter, Kenneth M Boucher, Lisa M Pappas, Inge J Stijleman, Priyanka Kanth, Kathryn R Byrne, Randall W Burt, Philip S Bernard, Deborah W Neklason
To identify gene expression biomarkers and pathways targeted by sulindac and erlotinib given in a chemoprevention trial with a significant decrease in duodenal polyp burden at 6 months (P < 0.001) in familial adenomatous polyposis (FAP) patients, we biopsied normal and polyp duodenal tissues from patients on drug versus placebo and analyzed the RNA expression. RNA sequencing was performed on biopsies from the duodenum of FAP patients obtained at baseline and 6-month endpoint endoscopy. Ten FAP patients on placebo and 10 on sulindac and erlotinib were selected for analysis...
November 6, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29109020/an-immortalized-microglial-cell-line-mocha-derived-from-rat-cochlea
#15
G M Seigel, S Manohar, Y Y Bai, D Ding, R Salvi
Microglia are glial-immune cells that are essential for the function and survival of the central nervous system. Microglia not only protect neural tissues from immunological insults, but also play a critical role in neural development and repair. However, little is known about the biology of microglia in the cochlea, the auditory portion of the inner ear. In this study, we detected TMEM119+, CD11b+, CD45+ and Iba1+ populations of cells in the rat cochlea, particularly in Rosenthal's canal, inner sulcus and stria vascularis...
November 3, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29107524/a-polyphenol-rich-cranberry-extract-reverses-insulin-resistance-and-hepatic-steatosis-independently-of-body-weight-loss
#16
Fernando F Anhê, Renato T Nachbar, Thibault V Varin, Vanessa Vilela, Stéphanie Dudonné, Geneviève Pilon, Maryse Fournier, Marc-André Lecours, Yves Desjardins, Denis Roy, Emile Levy, André Marette
OBJECTIVE: Previous studies have reported that polyphenol-rich extracts from various sources can prevent obesity and associated gastro-hepatic and metabolic disorders in diet-induced obese (DIO) mice. However, whether such extracts can reverse obesity-linked metabolic alterations remains unknown. In the present study, we aimed to investigate the potential of a polyphenol-rich extract from cranberry (CE) to reverse obesity and associated metabolic disorders in DIO-mice. METHODS: Mice were pre-fed either a Chow or a High Fat-High Sucrose (HFHS) diet for 13 weeks to induce obesity and then treated either with CE (200 mg/kg, Chow + CE, HFHS + CE) or vehicle (Chow, HFHS) for 8 additional weeks...
October 18, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29104078/eucalyptus-robusta-leaves-methanolic-extract-suppresses-inflammatory-mediators-by-specifically-targeting-tlr4-tlr9-mpo-cox2-inos-and-inflammatory-cytokines-in-experimentally-induced-endometritis-in-rats
#17
Aastha Tiwari, Preeti Singh, Pooja Jaitley, Sushant Sharma, Atul Prakash, Rajesh Mandil, Soumen Choudhury, Neeraj Kumar Gangwar, Satish K Garg
ETHNOPHARMACOLOGICAL RELEVANCE: Bacterial endometritis is one of the major causes of reproductive disorders including infertility in farm animals. Antibiotics are generally used for treatment of such disorders but now a days residues of antibiotics are of great public health concern, therefore, phytoremediation is being considered as an alternative to use of antibiotics. AIM OF THE STUDY: Present study was undertaken to investigate the efficacy of Eucalyptus robusta leaves methanolic extract against endometritis along with the possible mechanism of action especially targeting inflammatory biomarkers...
November 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29103106/tracing-the-spatio-temporal-dynamics-of-endangered-fin-whales-balaenoptera-physalus-within-baleen-whale-mysticeti-lineages-a-mitogenomic-perspective
#18
Jihyun Yu, Bo-Hye Nam, Joon Yoon, Eun Bae Kim, Jung Youn Park, Heebal Kim, Sook Hee Yoon
To explore the spatio-temporal dynamics of endangered fin whales (Balaenoptera physalus) within the baleen whale (Mysticeti) lineages, we analyzed 148 published mitochondrial genome sequences of baleen whales. We used a Bayesian coalescent approach as well as Bayesian inferences and maximum likelihood methods. The results showed that the fin whales had a single maternal origin, and that there is a significant correlation between geographic location and evolution of global fin whales. The most recent common female ancestor of this species lived approximately 9...
November 4, 2017: Genetica
https://www.readbyqxmd.com/read/29102164/soy-isoflavone-genistein-attenuates-lipopolysaccharide-induced-cognitive-impairments-in-the-rat-via-exerting-anti-oxidative-and-anti-inflammatory-effects
#19
Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Ali-Mohammad Rousta, Mohammad-Reza Azadi, Javad Fahanik-Babaei, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Systemic inflammation during infectious disorders usually accompanies chronic complications including cognitive dysfunction. Neuroinflammation and cognitive deficit are also observed in some debilitating neurological disorders like Alzheimer's and Parkinson's diseases. Genistein is a soy isoflavone with multiple beneficial effects including anti-inflammatory, anti-oxidative, and protective properties. In this research study, the effect of genistein in prevention of lipopolysaccharide (LPS)-induced cognitive dysfunction was investigated...
October 25, 2017: Cytokine
https://www.readbyqxmd.com/read/29095864/plastid-and-mitochondrial-genomes-of-coccophora-langsdorfii-fucales-phaeophyceae-and-the-utility-of-molecular-markers
#20
Louis Graf, Yae Jin Kim, Ga Youn Cho, Kathy Ann Miller, Hwan Su Yoon
Coccophora langsdorfii (Turner) Greville (Fucales) is an intertidal brown alga that is endemic to Northeast Asia and increasingly endangered by habitat loss and climate change. We sequenced the complete circular plastid and mitochondrial genomes of C. langsdorfii. The circular plastid genome is 124,450 bp and contains 139 protein-coding, 28 tRNA and 6 rRNA genes. The circular mitochondrial genome is 35,660 bp and contains 38 protein-coding, 25 tRNA and 3 rRNA genes. The structure and gene content of the C. langsdorfii plastid genome is similar to those of other species in the Fucales...
2017: PloS One
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