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https://www.readbyqxmd.com/read/28428799/a-novel-cytoplasmic-male-sterility-in-brassica-napus-inap-cms-with-carpelloid-stamens-via-protoplast-fusion-with-chinese-woad
#1
Lei Kang, Pengfei Li, Aifan Wang, Xianhong Ge, Zaiyun Li
A novel cytoplasmic male sterility (CMS) in Brassica napus (inap CMS) was selected from the somatic hybrid with Isatis indigotica (Chinese woad) by recurrent backcrossing. The male sterility was caused by the conversion of tetradynamous stamens into carpelloid structures with stigmatoid tissues at their tips and ovule-like tissues in the margins, and the two shorter stamens into filaments without anthers. The feminized development of the stamens resulted in the complete lack of pollen grains, which was stable in different years and environments...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28416371/modulation-by-nadph-oxidase-of-the-chronic-cardiovascular-and-autonomic-interaction-between-cyclosporine-and-nsaids-in-female-rats
#2
Ahmed F El-Yazbi, Karim S Ibrahim, Hanan M El-Gowelli, Nevine M El-Deeb, Mahmoud M El-Mas
Cyclosporine (CSA) and nonsteroidal antiinflammatory drugs (NSAIDs) are used together to manage arthritic disorders with an immune component. Previous reports showed contrasting effects for NSAIDs on CSA nephrotoxicity and acute elevations in blood pressure. Both effects were ameliorated or exaggerated after selective cyclooxygenase-2 (COX2) and nonselective COX inhibition, respectively. Here we investigated: (i) the interaction of CSA with NSAIDs possessing variable COX1/COX2 selectivities on hemodynamic, left ventricular (LV) and cardiac autonomic and histologic profiles, and (ii) role of NADPH-oxidase (NOX)/Rho-kinase (ROCK) pathway in the interaction...
April 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28416324/e4bp4-mediates-glucocorticoid-regulated-adipogenesis-through-cox2
#3
Yang Yang, Hongkui Wei, Tongxing Song, Anle Cai, Yuanfei Zhou, Jie Peng, Siwen Jiang, Jian Peng
Adipogenesis is mediated by glucocorticoids via transcriptional regulation of glucocorticoid receptor (GR) target genes. However, the mechanism by which GR participates in adipogenesis has hitherto been poorly characterized. In this study, E4 promoter-binding protein 4 (E4BP4) was found to have a critical role in adipogenic differentiation of preadipocytes. Gain-of-function and loss-of-function studies revealed that E4BP4 acts as a positive regulator of adipogenesis in 3T3-L1 cells. E4BP4 was markedly induced by glucocorticoid (dexamethasone) via GR and cAMP response element-binding protein (CREB) during adipogenesis...
April 14, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28415673/camp-pka-creb-bdnf-signaling-pathway-in-hippocampus-mediates-cyclooxygenase-2-induced-learning-memory-deficits-of-rats-subjected-to-chronic-unpredictable-mild-stress
#4
Ying Luo, Shengnan Kuang, Huan Li, Dongzhi Ran, Junqing Yang
To investigate the mechanism of cyclooxygenase 2 (COX2) in learning and memory impairments in rats subjected to chronic unpredictable mild stress (CUMS), meloxicam was used intragastrically to inhibit the activity of cyclooxygenase 2. Moreover, cyclooxygenase 2 over-expressing or RNA interfere lentivirus was injected intraventricularly to increase or decrease the enzyme's expression, respectively. The body weights and sucrose consumption were used to analyze depressive behaviors, while the Morris water maze and step-down-type passive avoidance tests were carried out to evaluate the learning-memory functions...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411132/methyl-jasmonate-attenuates-memory-dysfunction-and-decreases-brain-levels-of-biomarkers-of-neuroinflammation-induced-by-lipopolysaccharide-in-mice
#5
Umukoro Solomon, Eduviere Anthony Taghogho
Neuroinflammation plays a central role in the etiology and progression of Alzheimer's disease (AD), a neurodegenerative disorder, characterized by a gradual loss of memory functions. Thus, it has been proposed that agents that could reduce inflammatory processes in AD brains might be useful for the treatment of the disease. Methyl jasmonate (MJ) is a bioactive compound, which has been reported to exhibit anti-amnesic and in vitro anti-inflammatory activities. In this study, we further examine its effects on the brain levels of biomarkers of neuroinflammation in lipopolysaccharide (LPS)-induced memory deficits in mice...
April 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28405625/resistance-to-hypertension-mediated-by-intercalated-cells-of-the-collecting-duct
#6
Johannes Stegbauer, Daian Chen, Marcela Herrera, Matthew A Sparks, Ting Yang, Eva Königshausen, Susan B Gurley, Thomas M Coffman
The renal collecting duct (CD), as the terminal segment of the nephron, is responsible for the final adjustments to the amount of sodium excreted in urine. While angiotensin II modulates reabsorptive functions of the CD, the contribution of these actions to physiological homeostasis is not clear. To examine this question, we generated mice with cell-specific deletion of AT1A receptors from the CD. Elimination of AT1A receptors from both principal and intercalated cells (CDKO mice) had no effect on blood pressures at baseline or during successive feeding of low- or high-salt diets...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28404662/slc25-family-member-genetic-interactions-identify-a-role-for-hem25-in-yeast-electron-transport-chain-stability
#7
J Noelia Dufay, J Pedro Fernández-Murray, Christopher R McMaster
The SLC25 family member SLC25A38 (Hem25 in yeast) was recently identified as a mitochondrial glycine transporter that provides substrate to initiate heme/hemoglobin synthesis. Mutations in the human SLC25A38 gene cause congenital sideroblastic anemia. The full extent to which SLC25 family members co-regulate heme synthesis with other mitochondrial functions is not clear. In this study, we surveyed 29 non-essential SLC25 family members in Saccharomyces cerevisiae for their ability to support growth in the presence and absence of HEM25...
April 12, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28403200/identification-of-potential-biomarkers-in-donor-cows-for-in-vitro-embryo-production-by-granulosa-cell-transcriptomics
#8
Gianluca Mazzoni, Suraya M Salleh, Kristine Freude, Hanne S Pedersen, Lotte Stroebech, Henrik Callesen, Poul Hyttel, Haja N Kadarmideen
The Ovum Pick Up-In vitro Production (OPU-IVP) of embryos is an advanced reproductive technology used in cattle production but the complex biological mechanisms behind IVP outcomes are not fully understood. In this study we sequenced RNA of granulosa cells collected from Holstein cows at oocyte aspiration prior to IVP, to identify candidate genes and biological mechanisms for favourable IVP-related traits in donor cows where IVP was performed separately for each animal. We identified 56 genes significantly associated with IVP scores (BL rate, kinetic and morphology)...
2017: PloS One
https://www.readbyqxmd.com/read/28402673/functionalized-lipid-polymer-hybrid-nanoparticles-mediated-co-delivery-of-methotrexate-aceclofenac-a-synergistic-effect-in-breast-cancer-with-improved-pharmacokinetics-attributes
#9
Neeraj K Garg, Rajeev K Tyagi, Gajanand Sharma, Ashay Jain, Bhupinder Singh, Sanyog Jain, O P Katare
Present study was aimed to co-encapsulate methotrexate (MTX) and aceclofenac (ACL) in fucose anchored lipid-polymer hybrid nanoparticles (Fu-LPHNPs) to achieving target specific and controlled delivery for developing therapeutic interventions against breast cancer. The effective combination therapy requires co-administration of drugs to achieving synergistic effect on tumor with minimum adverse effects. Present study investigates the potential of co-delivery of MTX & ACL through LPHNPs in MCF-7 and triple negative breast cancer cells (MDA-MB-231) to reduce the adverse effects...
April 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28402056/prostaglandin-synthesis-enzymes-gene-transcription-in-bitches-with-endometritis
#10
M C García Mitacek, R G Praderio, M C Stornelli, R L de la Sota, M A Stornelli
Endometritis is a major cause of infertility in many domestic species. However, until now the pathogenesis of the endometritis in the bitch is unclear. The aim of this study was to evaluate the gene transcription pattern of prostaglandin (PG) synthesis enzymes (cyclooxygenase [COX2], PTGES-1 and PGFS) in the endometrium of bitches with or without endometritis. Thirty mixed breed bitches in dioestrus, aged between 1 and 5 years, and weighing between 10 and 30 kg were used. After ovariohysterectomy (OVX), uterine biopsy samples were collected from the middle part of both horns...
April 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28397013/modulatory-efficacy-of-dieckol-on-xenobiotic-metabolizing-enzymes-cell-proliferation-apoptosis-invasion-and-angiogenesis-during-ndea-induced-rat-hepatocarcinogenesis
#11
Velayutham Sadeeshkumar, Arul Duraikannu, Samuthrapandian Ravichandran, Paulrasu Kodisundaram, Wilson Sylvester Fredrick, Rajagopal Gobalakrishnan
Dieckol (DEK) is a major polyphenol of marine brown seaweed Ecklonia cava which is a potential candidate for cancer therapy. However, the underlying mechanism of DEK as an anticancer drug remains to be elucidated. In this study, we evaluated the molecular mechanisms involved in the chemopreventive efficacy of DEK in N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis rats by analyzing markers of xenobiotic-metabolizing enzymes (XMEs), apoptosis, invasion, and angiogenesis. Rats administered NDEA developed hepatocarcinogenesis that displayed apoptosis avoidance coupled to upregulation of pro-inflammatory, invasion, and angiogenesis markers...
April 10, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28385737/lack-of-stat6-attenuates-inflammation-and-drives-protection-against-early-steps-of-colitis-associated-colon-cancer
#12
Sonia A Leon-Cabrera, Emmanuel Molina-Guzman, Yael G Delgado-Ramirez, Armando Vázquez-Sandoval, Yadira Ledesma-Soto, Carlos G Pérez-Plasencia, Yolanda I Chirino, Norma L Delgado-Buenrostro, Miriam Rodríguez-Sosa, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Emma B Gutierrez-Cirlos, Luis E Arias-Romero, Luis I Terrazas
Colitis-associated colon cancer (CAC) is one of the most common malignant neoplasms and a leading cause of death. The immunologic factors associated with CAC development are not completely understood. Signal transducer and activator of transcription 6 (STAT6) is part of an important signaling pathway for modulating intestinal immune function and homeostasis. However, the role of STAT6 in colon cancer progression is unclear. Following CAC induction in wild-type (WT) and STAT6-deficient mice (STAT6(-/-)), we found that 70% of STAT6(-/-) mice were tumor-free after 8 weeks, whereas 100% of WT mice developed tumors...
April 6, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28380697/graphene-oxide-enrichment-collagen-membranes-improves-dpscs-differentiation-and-controls-inflammation-occurrence
#13
Milena Radunovic, Marianna De Colli, Patrizia De Marco, Chiara Di Nisio, Antonella Fontana, Adriano Piattelli, Amelia Cataldi, Susi Zara
Collagen membranes are used in oral surgery for bone defects treatment acting as a barrier that does not allow the invasion of soft tissue into the growing bone. To improve biocompatibility collagen membranes were coated with graphene oxide (GO), a graphene derivative. The aim of this study was to investigate the biocompatibility of GO coated collagen membranes on human dental pulp stem cells (DPSCs) focusing on biomaterial cytotoxicity, ability to promote DPSCs differentiation process and to control inflammation event induction...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28372536/hoxa10-and-hoxa11-regulate-the-expression-of-contraction-associated-proteins-and-contribute-to-regionalized-myometrium-phenotypes-in-women
#14
Yinan Li, Haolong Li, Ning Xie, Ruiqi Chen, Ahn Rhi Lee, Donna Slater, Stephen Lye, Xuesen Dong
A relaxed fundus (FUN) and a contracted lower uterine segment (LUS) of human myometrium are required for maintaining pregnancy. How this regional myometrium function is regulated remains unclear. We have previously reported that the homeobox protein A13 (HoxA13) is highly expressed in the LUS and can enhance the expression of contraction-associated proteins (CAPs). Here, we show that in contrast to HoxA13, HoxA10 and HoxA11 genes are expressed at significantly higher levels in myometrium tissues and primary myocytes from the FUN...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28369131/liver-x-receptors-activation-through-to901317-binding-reduces-neuroinflammation-in-parkinson-s-disease
#15
Irene Paterniti, Michela Campolo, Rosalba Siracusa, Marika Cordaro, Rosanna Di Paola, Vittorio Calabrese, Michele Navarra, Salvatore Cuzzocrea, Emanuela Esposito
Parkinson's disease (PD) is a neurodegenerative disease in which degeneration of nigrostriatal neurons and inflammation are key players. The aim of our study was to analyze the function of LXRs in neurodegenerative diseases as PD using in vivo, ex vivo and in vitro models of PD; for this purpose, we observed the effects of the LXR agonist, TO901317, in neuroinflammatory pathway related to PD. We performed an in vivo model of PD using the neurotoxin 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) and our results clearly showed that TO901317 administration reduces all of the inflammatory markers involved in PD such as iNOS and COX2, IκB-α and NF-κB...
2017: PloS One
https://www.readbyqxmd.com/read/28368394/inhibition-of-cyclooxygenase-2-mediated-matriptase-activation-contributes-to-the-suppression-of-prostate-cancer-cell-motility-and-metastasis
#16
C-J Ko, S-W Lan, Y-C Lu, T-S Cheng, P-F Lai, C-H Tsai, T-W Hsu, H-Y Lin, H-Y Shyu, S-R Wu, H-H Lin, P-W Hsiao, C-H Chen, H-P Huang, M-S Lee
Chronic inflammation plays an important role in cancer development and progression. Cyclooxygenases-2 (COX-2) is a key enzyme in generating prostaglandins causing inflammation, is often found to be overexpressed in prostate cancer (PCa) and is correlated with PCa cell invasion and metastasis. We aim to investigate the molecular mechanism of how COX-2 promotes PCa cell invasion and metastasis and to evaluate the effect of COX-2 inhibitors in a selected model of PCa progression. Our results showed that the expression of COX-2 and Interleukin 1β (IL-1β) was upregulated in highly invasive PCa cells and was correlated with the activated levels of membrane-anchored serine protease matriptase...
April 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28362325/possible-roles-of-cc-and-cxc-chemokines-in-regulating-bovine-endometrial-function-during-early-pregnancy
#17
Ryosuke Sakumoto, Ken-Go Hayashi, Shiori Fujii, Hiroko Kanahara, Misa Hosoe, Tadashi Furusawa, Keiichiro Kizaki
The aim of the present study was to determine the possible roles of chemokines in regulating bovine endometrial function during early pregnancy. The expression of six chemokines, including CCL2, CCL8, CCL11, CCL14, CCL16, and CXCL10, was higher in the endometrium at 15 and 18 days of pregnancy than at the same days in non-pregnant animals. Immunohistochemical staining showed that chemokine receptors (CCR1, CCR2, CCR3, and CXCR3) were expressed in the epithelial cells and glandular epithelial cells of the bovine endometrium as well as in the fetal trophoblast obtained from a cow on day 18 of pregnancy...
March 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28359330/evolutionarily-recent-insertional-fission-of-mitochondrial-cox2-into-complementary-genes-in-bilaterian-metazoa
#18
Przemyslaw Szafranski
BACKGROUND: Mitochondrial genomes (mtDNA) of multicellular animals (Metazoa) with bilateral symmetry (Bilateria) are compact and usually carry 13 protein-coding genes for subunits of three respiratory complexes and ATP synthase. However, occasionally reported exceptions to this typical mtDNA organization prompted speculation that, as in protists and plants, some bilaterian mitogenomes may continue to lose their canonical genes, or may even acquire new genes. To shed more light on this phenomenon, a PCR-based screen was conducted to assess fast-evolving mtDNAs of apocritan Hymenoptera (Arthropoda, Insecta) for genomic rearrangements that might be associated with the modification of mitochondrial gene content...
March 31, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28356021/novel-thiourea-derivatives-bearing-sulfonamide-moiety-as-anticancer-agents-through-cox-2-inhibition
#19
Mostafa M Ghorab, Mohamed S A El-Gaby, Mansour S Alsaid, Yaseen A M M Elshaier, Aiten M Soliman, Fardous F El-Senduny, Farid A Badria
A series of novel thioureas 5a-n, 8, quinazoline 6, benzo[g]quinazoline 7 and benzo[1,3] dioxole 10, bearing a sulfonamide moiety were synthesized from the starting compound N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2. The target compounds were screened against HepG2, MCF-7, Caco-2, HCT-116, PC-3 cancer cell lines and VERO-B normal cell line. Out of all the tested compounds, compound 5c showed a broad selective cytotoxicity against HepG2, MCF-7, Caco-2 and PC-3 cancer cells. Moreover, a sensitization assay was performed on Caco-2 cells, compound 5c proved to act as a chemosensitizer for cisplatin on colon cancer (Caco-2) cells...
March 27, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28352129/cyclooxygenase-2-signalling-pathway-in-the-cortex-is-involved-in-the-pathophysiological-mechanisms-in-the-rat-model-of-depression
#20
Qi Chen, Ying Luo, Shengnan Kuang, Yang Yang, Xiaoyan Tian, Jie Ma, Shaoshan Mai, Lai Xue, Junqing Yang
This study was designed to investigate the effect of the cortical cyclooxygenase-2 (COX2) pathway on depressive behaviour in rats. Meloxicam, COX2 overexpressed lentivirus and COX2 RNAi lentivirus were administered to Sprague-Dawley rats subjected to chronic unpredictable mild stress (CUMS). Behaviour tests, biochemistry and immunohistochemistry methods, enzyme-linked immunosorbent assays, western blotting and reverse transcription polymerase chain reactions were used to evaluate the changes in rat behaviour and the cortical COX2 pathway...
March 28, 2017: Scientific Reports
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