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Fructosamine

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https://www.readbyqxmd.com/read/29223135/simultaneous-anti-diabetic-and-anti-vascular-calcification-activity-of-nocardia-sp-utmc-751
#1
Fatemeh Salimi, Saeedeh Jafari-Nodooshan, Nazanin Zohourian, Sedighe Kolivand, Javad Hamedi
Alpha-amylase can act as a significant player in causing hyperglycemia, leading to protein glycation, which is the main complication in this condition, besides causing vascular calcification (VC), an important vascular failure caused due to thisIn order to find a natural source of the biocompounds with inhibitory effects on alpha-amylase,, fifteen fermentation broth extracts of actinobacteria (FBEA) (200 μg mL-1 ) have been screened. Finally, the effects of the most efficient FBE have been investigated on osteopontin (OPN, a VC marker) mRNA level in the vascular smooth muscle cells under the calcification conditions, and the chemical constituents of the most efficient FBE were analyzed using GC-MS analysis...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29209605/the-effect-of-cigarette-smoking-during-pregnancy-on-endocrine-pancreatic-function-and-fetal-growth-a-pilot-study
#2
Fatima Lockhart, Anthony Liu, Bernard Linton Champion, Michael John Peek, Ralph Kay Heinrich Nanan, Alison Sally Poulton
Introduction: Cigarette smoking in pregnancy is a common cause of fetal growth restriction. We aimed to investigate endocrine pancreatic function of mother-infant dyads in relation to cigarette smoking, as a possible mechanism for the poor fetal growth. Methods: Prospective study of smoking mothers (10 cigarettes or more per day, self-reported to the midwife) and non-smoker control mothers during their first pregnancy. Insulin, glucose, C-peptide, HbA1C, fructosamine, prolactin, serotonin, and cortisol were measured in maternal blood at 24-26 weeks and in umbilical cord blood at birth...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29209496/abnormal-carbohydrate-metabolism-in-a-canine-model-for-muscular-dystrophy
#3
Andressa R Amaral, Márcio A Brunetto, Marina P Brólio, Daniela S Cima, Maria A Miglino, João Paulo F Santos, Carlos E Ambrósio
The canine golden retriever muscular dystrophy (GRMD) model is the best animal model for studying Duchenne muscular dystrophy in humans. Considering the importance of glucose metabolism in the muscles, the existence of metabolic and endocrine alterations in a wide range of muscular dystrophies, and the pre-existing relationship between blood insulin concentration and muscular atrophy, the present study aimed to evaluate the postprandial glucose and insulin response in GRMD dogs. A total of eighteen golden retriever dogs were randomly distributed into three experimental groups: healthy/control (G1), female GRMD carriers (G2), and male dogs affected by GRMD (G3)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29191422/resistant-starch-produces-antidiabetic-effects-by-enhancing-glucose-metabolism-and-ameliorating-pancreatic-dysfunction-in-type-2-diabetic-rats
#4
Hui Sun, Xiaohan Ma, Shiqi Zhang, Dan Zhao, Xiong Liu
The aim of the study was to evaluate the hypoglycemic effect of low, medium, and high doses of resistant starch type 2(RS2;100, 150, and 200g/kg) for 28days and explore its potential mechanism of this effect in type 2 diabetic rats treated with high-glucose-fat diet and low-dose streptozotocin(STZ). RS2 treatment induced better regulation of lipid in plasma and liver, fructosamine, oral glucose tolerance test, insulin, glucose metabolism and pancreatic damage in diabetic rats. The best hypoglycemic activity was observed after the medium-dose RS2 treatment...
November 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29172917/prospective-evaluation-of-a-protocol-for-transitioning-porcine-lente-insulin-treated-diabetic-cats-to-human-recombinant-protamine-zinc-insulin
#5
Ruth Gostelow, Katarina Hazuchova, Christopher Scudder, Yaiza Forcada, David Church, Stijn J M Niessen
Objectives The objective was to evaluate a nadir-led protocol for transitioning porcine lente insulin suspension (PLIS)-treated diabetic cats onto human recombinant protamine zinc insulin (PZIR). Methods Recently diagnosed (<5 months) diabetic cats, treated with PLIS q12h for ⩾6 weeks, were recruited. Fructosamine, 24 h blood glucose curve (BGC), quality of life assessment (DIAQoL-pet score) and Diabetic Clinical Score (DCS) were assessed at enrolment (PLIS-treated) and 2, 4 and 12 weeks after transitioning to PZIR (starting dose 0...
March 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29168862/inhibition-of-advanced-glycation-endproducts-during-fish-sausage-preparation-by-transglutaminase-and-chitosan-oligosaccharides-induced-enzymatic-glycosylation
#6
Jing Wang, Long Zou, Fangzhou Yuan, Liangtao Lv, Shenglan Tian, Zhenxing Li, Hong Lin
Advanced glycation endproducts (AGEs) are the harmful products of non-enzymatic reactions in foods formed during the heating process. In order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied. The results indicated that the TGase/COS ratio of 1 : 1 could inhibit the formation of AGEs, showing especially a decreased N(ε)-carboxymethyl-lysine (CML) content and a twice higher inhibition rate (36...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168124/in-vitro-inhibitory-activity-of-acca-sellowiana-fruit-extract-on-end-products-of-advanced-glycation
#7
Alethia Muñiz, Abraham H Garcia, Rosa M Pérez, Efren V García, Daphne E González
INTRODUCTION: Hyperglycemia plays an important role in the pathogenesis of diabetic complications, as it increases protein glycation, as well as the progressive accumulation of advanced glycation end products (AGEs), which are complex structures that produce fluorescence. The glycation reaction raises the levels of protein carbonyl, N (ε)-(carboxymethyl)lysine (CML), and fructosamine and decreases the level of thiol groups. METHODS: In the present study, the antiglycation activity was determined by fluorescence intensity using the bovine serum albumin (BSA)/glucose, CML method, and the level of fructosamine...
November 22, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29159002/a-case-report-of-fructosamine-s-unreliability-as-a-glycemic-control-assessment-tool-in-nephrotic-syndrome
#8
Sri HarshaVardhan Senapathi, Ravi Bhavsar, Regina Kaur, Paul Kim, Issac Sachmechi
Fructosamine (FA) is a glycated primary amine widely used as an alternative method for the assessment of glycemic control when glycosylated hemoglobin (HbA1c) measurement is unreliable or if there is a need for short-term glycemic control monitoring. We report a case of a 36-year-old male patient with a six-year history of poorly controlled type 2 diabetes mellitus and nephrotic syndrome. As the nephrotic syndrome progressed, we observed a decline in his serum FA levels that did not correlate with his increased HbA1c due to significant albuminuria...
September 16, 2017: Curēus
https://www.readbyqxmd.com/read/29152244/effect-of-dietary-protein-intake-on-the-body-composition-and-metabolic-parameters-of-neutered-dogs
#9
Iris Mayumi Kawauchi, Juliana Toloi Jeremias, Paula Takeara, Danilo Ferreira de Souza, Júlio Cesar de Carvalho Balieiro, Karina Pfrimer, Marcio Antonio Brunetto, Cristiana Fonseca Ferreira Pontieri
Neutering is a common veterinary recommendation and is often associated with obesity development. Thus, the aim of the present study was to evaluate the effects of two different amounts of protein intake by neutered dogs regarding maintenance energy requirement (MER), body composition, and biochemical and hormonal parameters. A total of fourteen healthy adult dogs were fed either a diet containing 59·7 g protein/1000 kcal (4184 kJ) (P60) or a diet with 94·0 g protein/1000 kcal (4184 kJ) (P94) for 26 weeks after neutering to maintain their body weight prior to neutering...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29139146/effects-of-the-sodium-glucose-cotransporter-2-sglt2-inhibitor-velagliflozin-a-new-drug-with-therapeutic-potential-to-treat-diabetes-in-cats
#10
M Hoenig, M Clark, D J Schaeffer, D Reiche
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are used in the treatment of human diabetics. They increase glucose excretion and correct hyperglycemia. We examined the investigational SGLT2 inhibitor velagliflozin in two groups of six neutered adult obese cats (equal gender distribution). Placebo (Pl) or drug (D; 1 mg/kg) was administered for 35 days. Routine blood examinations, fructosamine, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29135677/a-cheap-simple-test-that-predicts-complications-what-s-not-to-like-commentary-on-an-article-by-noam-shohat-md-et-al-serum-fructosamine-a-simple-and-inexpensive-test-for-assessing-preoperative-glycemic-control
#11
https://www.readbyqxmd.com/read/29135663/serum-fructosamine-a-simple-and-inexpensive-test-for-assessing-preoperative-glycemic-control
#12
Noam Shohat, Majd Tarabichi, Eric H Tischler, Serge Jabbour, Javad Parvizi
BACKGROUND: Although the medical community acknowledges the importance of preoperative glycemic control, the literature is inconclusive and the proper metric for assessment of glycemic control remains unclear. Serum fructosamine reflects the mean glycemic control in a shorter time period compared with glycated hemoglobin (HbA1c). Our aim was to examine its role in predicting adverse outcomes following total joint arthroplasty. METHODS: Between 2012 and 2013, we screened all patients undergoing total joint arthroplasty preoperatively using serum HbA1c, fructosamine, and blood glucose levels...
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29083240/a-comparative-research-on-obesity-hypertension-by-the-comparisons-and-associations-between-waist-circumference-body-mass-index-with-systolic-and-diastolic-blood-pressure-and-the-clinical-laboratory-data-between-four-special-chinese-adult-groups
#13
Ou Wu, Jian-Hang Leng, Fen-Fang Yang, Hai-Ming Yang, Hu Zhang, Zeng-Fang Li, Xing-Yu Zhang, Cheng-Da Yuan, Jia-Jia Li, Qi Pan, Wei Liu, Yan-Jun Ren, Bing Liu, Qing-Min Liu, Cheng-Jian Cao
BACKGROUND: The obesity-hypertension pathogenesis is complex. From the phenotype to molecular mechanism, there is a long way to clarify the mechanism. To explore the association between obesity and hypertension, we correlate the phenotypes such as the waist circumference (WC), body mass index (BMI), systolic blood pressure (SB), and diastolic blood pressure (DB) with the clinical laboratory data between four specific Chinese adult physical examination groups (newly diagnosed untreated just-obesity group, newly diagnosed untreated obesity-hypertension group, newly diagnosed untreated just-hypertension group, and normal healthy group), and the results may show something...
October 30, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29066600/evidence-that-differences-in-fructosamine-3-kinase-activity-may-be-associated-with-the-glycation-gap-in-human-diabetes
#14
Simon J Dunmore, Amr S Al-Derawi, Ananth U Nayak, Aruna Narshi, Alan M Nevill, Anne Hellwig, Andrew Majebi, Paul Kirkham, James E Brown, Baldev M Singh
The phenomenon of a discrepancy between glycated haemoglobin levels and other indicators of average glycaemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in deglycation in turn leading to altered production of Advanced Glycation End (AGE) products. We hypothesised that variations in the level of the deglycating enzyme Fructosamine-3-kinase (FN3K) might be associated with the GGap...
October 24, 2017: Diabetes
https://www.readbyqxmd.com/read/29056888/effect-of-garlic-supplement-in-the-management-of-type-2-diabetes-mellitus-t2dm-a-meta-analysis-of-randomized-controlled-trials
#15
Juan Wang, Xiuming Zhang, Haili Lan, Weijia Wang
The present study was designed to systematically evaluate the clinical efficacy and safety of garlic supplement in the management of type 2 diabetes mellitus (T2DM). PubMed, EMBASE, the Cochrane Library, and China National Knowledge Internet (CNKI) were searched for relevant randomized controlled trials (RCTs) by using the terms garlic and T2DM up to April 2017. The quality of included RCTs was assessed by the Cochrane tool of risk of bias, and data of outcomes were pooled by REVMAN 5.3. Clinical factors were handled by meta-regression and subgroup analysis, and risk of publication bias was explored by inverted funnel plots...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29056676/serum-fructosamine-concentration-in-uncontrolled-hyperthyroid-diabetic-cats-is-within-the-population-reference-interval
#16
Arnon Gal, Brie Trusiano, Adrienne F French, Nicolas Lopez-Villalobos, Amy L MacNeill
Diabetes mellitus is a common endocrinopathy of cats that is characterized by persistent fasting hyperglycemia. However, stress induces substantial hyperglycemia in cats that poses a challenge to the veterinarian who may wrongly interpret the high serum concentration of blood glucose as evidence of diabetes mellitus. Fructosamine is a glycated serum protein that serves as an index of glycemic control in cats and is useful because it is not affected by stress hyperglycemia. However, factors such as body weight, hypoproteinemia, and increased serum thyroid hormone concentration can alter fructosamine concentration...
March 15, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29055090/performance-of-nontraditional-hyperglycemia-biomarkers-by-chronic-kidney-disease-status-in-older-adults-with-diabetes-results-from-the-atherosclerosis-risk-in-communities-study
#17
Molly Jung, Bethany Warren, Morgan Grams, Yuenting Diana Kwong, Tariq Shafi, Josef Coresh, Casey M Rebholz, Elizabeth Selvin
BACKGROUND: In persons with chronic kidney disease (CKD), hemoglobin A1c (HbA1c) may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. We investigated associations of HbA1c, glycated albumin, and fructosamine with fasting glucose by CKD categories. METHODS: Cross-sectional analysis of 1,665 Atherosclerosis Risk in Communities Study participants with diagnosed diabetes aged 65 years or older...
October 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29043349/comparative-suppressing-effects-of-black-and-green-teas-on-the-formation-of-advanced-glycation-end-products-ages-and-age-induced-oxidative-stress
#18
P Ramlagan, P Rondeau, C Planesse, V S Neergheen-Bhujun, E Bourdon, T Bahorun
This study aimed at investigating and comparing the anti-diabetic potential of black and green teas. Biochemical analyses indicate higher antioxidant potency, significantly correlated with the phytochemicals present, in green teas compared to black teas. Both extracts afforded a similar level of protection to erythrocytes against peroxyl radical-induced lysis. Non-cytotoxic concentration of green and black tea extracts significantly reduced the reactive oxygen species (ROS) production (P < 0.01), lowered the oxidation of proteins (P < 0...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/29040025/effect-of-chronic-consumption-of-pistachios-pistacia-vera-l-on-glucose-metabolism-in-pre-diabetics-and-type-2-diabetics-a-systematic-review
#19
P V M Ribeiro, A Silva, A P Almeida, H H Hermsdorff, R C Alfenas
Pistachio is a nut with high polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFA), polyphenols and carotenoids content, and the synergism between these compounds appears to affect glucose metabolism. In this systematic review we analyzed studies in which the effect of chronic consumption of pistachio on markers of glucose metabolism was evaluated in pre-diabetic and type 2 diabetics. We used the PubMed, Scopus, Cochrane and Lilacs databases. The research terms used were pistachio, pre-diabetes, type 2 diabetes mellitus, insulin resistance, blood glucose, hyperglycemia and glycated hemoglobin (HbA1c)...
October 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29033370/d-ribose-as-a-contributor-to-glycated-haemoglobin
#20
Xixi Chen, Tao Su, Yao Chen, Yingge He, Ying Liu, Yong Xu, Yan Wei, Juan Li, Rongqiao He
Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fructosamine formation for d-ribose was approximately 60 times higher than that for d-glucose at the initial stage. Zucker Diabetic Fatty (ZDF) rat, a common model for type 2 diabetes mellitus (T2DM), had high levels of d-ribose and HbA1c, accompanied by a decrease of transketolase (TK) in the liver...
November 2017: EBioMedicine
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