keyword
https://read.qxmd.com/read/38547510/sulforaphane-improves-redox-homeostasis-and-right-ventricular-contractility-in-a-model-of-pulmonary-hypertension
#1
JOURNAL ARTICLE
Adriana Conzatti, Rafael Colombo, Rafaela Siqueira, Cristina Campos-Carraro, Patrick Turck, Alexandre Luz de Castro, Adriane Belló-Klein, Alex Sander da Rosa Araujo
Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance, imposing overload on the right ventricle (RV) and imbalance of redox state. Our study investigated the influence of treatment with sulforaphane (SFN), found in cruciferous vegetables, on right ventricle (RV) remodeling and redox homeostasis in monocrotaline-induced pulmonary arterial hypertension (PAH). Male Wistar rats were separated into four groups: control (CTR); control + sulforaphane (CTR + SFN); monocrotaline (MCT); monocrotaline + sulforaphane (MCT + SFN)...
March 14, 2024: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/38547473/harnessing-the-potential-of-self-assembled-peptide-hydrogels-for-neural-regeneration-and-tissue-engineering
#2
REVIEW
Haniyeh Najafi, Ghazal Farahavar, Mahboobeh Jafari, Samira Sadat Abolmaali, Negar Azarpira, Ali Mohammad Tamaddon
Spinal cord injury, traumatic brain injury, and neurosurgery procedures usually lead to neural tissue damage. Self-assembled peptide (SAP) hydrogels, a type of innovative hierarchical nanofiber-forming peptide sequences serving as hydrogelators, have emerged as a promising solution for repairing tissue defects and promoting neural tissue regeneration. SAPs possess numerous features such as adaptable morphologies, biocompatibility, injectability, tunable mechanical stability, and mimicking of the native extracellular matrix...
March 28, 2024: Macromolecular Bioscience
https://read.qxmd.com/read/38547315/one-shot-single-cell-proteome-and-metabolome-analysis-strategy-for-the-same-single-cell
#3
JOURNAL ARTICLE
Jie Wu, Qin-Qin Xu, Yi-Rong Jiang, Jian-Bo Chen, Wei-Xin Ying, Qian-Xi Fan, Hui-Feng Wang, Yu Wang, Shao-Wen Shi, Jian-Zhang Pan, Qun Fang
Characterizing the profiles of proteome and metabolome at the single-cell level is of great significance in single-cell multiomic studies. Herein, we proposed a novel strategy called one-shot single-cell proteome and metabolome analysis (scPMA) to acquire the proteome and metabolome information in a single-cell individual in one injection of LC-MS/MS analysis. Based on the scPMA strategy, a total workflow was developed to achieve the single-cell capture, nanoliter-scale sample pretreatment, one-shot LC injection and separation of the enzyme-digested peptides and metabolites, and dual-zone MS/MS detection for proteome and metabolome profiling...
March 28, 2024: Analytical Chemistry
https://read.qxmd.com/read/38547077/inoculation-of-pan02-cells-produces-tumor-nodules-in-mouse-pancreas-characterization-of-a-novel-orthotopic-pancreatic-ductal-adenocarcinoma-tumor-model-for-interventional-studies
#4
JOURNAL ARTICLE
James I Griffin, Xinyue Chen, Luqi Duan, Qingxin Mu, Rodney J Y Ho
Preclinical models of cancer are vital for assessing and predicting efficacies and toxicities of novel treatments prior to testing in human subjects. Current pancreatic tumor models exhibit variable growth rates, unpredictable tumor size after implantation in non-native tissues, or require surgical implantation. Surgical implantation in the pancreas may produce not only unpredictable tumor uptake but could also elicit additional inflammatory responses. In searching for a pancreatic carcinoma cell that can be introduced into a mouse via simple injection, we found that Pan02, a murine ductal pancreatic adenocarcinoma derived from a pancreatic lesion of a C57BL/6 mouse, inoculated peritoneally can consistently produce pancreatic tumors...
2024: PloS One
https://read.qxmd.com/read/38547057/direct-solar-energy-conversion-on-zinc-air-battery
#5
JOURNAL ARTICLE
Xinlong Fu, Feng He, Xin Liu, Binghui Ge, Deyi Zhang, Qian Chang, Jingchi Gao, Xiaodong Li, Changshui Huang, Yuliang Li
A concept of solar energy convertible zinc-air battery (SZAB) is demonstrated through rational design of an electrode coupled with multifunction. The multifunctional electrode is fabricated using nitrogen-substituted graphdiyne (N-GDY) with large π-conjugated carbonous network, which can work as photoresponsive bifunctional electrocatalyst, enabling a sunlight-promoted process through efficient injection of photoelectrons into the conduction band of N-GDY. SZAB enables direct conversion and storage of solar energy during the charging process...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38546968/revisiting-large-complex-ventral-hernia-repair-multimodal-hybrid-technique-deploying-preoperative-botulinum-toxin-a-injection-laparoscopic-anterior-components-separation-and-open-mesh-repair
#6
JOURNAL ARTICLE
Khawar S Hashmi, Yagazie Zina Udeaja, Jamasp Dastur, Simon Allen, Partha Das
In the past, various techniques had been described to repair large complex ventral hernias. Laparoscopic technique of components separation showed low complication rates and better overall outcome. Recently, Botulinum Toxin A (BTA) has shown benefit in achieving tension-free repair. We describe here our multimodal technique combining BTA injection, laparoscopic anterior components separation (LACS) and open mesh repair. Ten consecutive cases performed over 3 years were studied. A standardised technique was used with a reasonably short learning curve...
March 28, 2024: Updates in Surgery
https://read.qxmd.com/read/38546840/physicochemical-compatibility-of-caffeine-citrate-and-caffeine-base-injections-with-parenteral-medications-used-in-neonatal-intensive-care-settings
#7
JOURNAL ARTICLE
D Thisuri N De Silva, Michael Petrovski, Tobias Strunk, Nabeelah Mukadam, Madhu Page-Sharp, Brioni R Moore, Kevin T Batty
PURPOSE: To investigate the physicochemical compatibility of caffeine citrate and caffeine base injections with 43 secondary intravenous (IV) drugs used in Neonatal Intensive Care Unit (NICU) settings. METHODS: Caffeine citrate (20 mg/mL or 10 mg/mL) or caffeine base injection (10 mg/mL) were mixed in a volume ratio of 1:1 with the secondary drug solution to simulate Y-site co-administration procedures in NICUs. Physical compatibility was evaluated based on visual observation for 2 h, against a black and white background and under polarised light, for changes in colour, precipitation, haze and evolution of gas...
March 28, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38546825/diagnostic-value-of-dual-time-point-68-ga-psma-pet-ct-image-for-benign-and-malignant-lesions-in-patients-with-prostate-cancer
#8
JOURNAL ARTICLE
Liu Xiao, Minggang Su, Yuhao Li
OBJECTIVE: This study aimed to ascertain the diagnostic efficacy of routine 68 Ga-PSMA imaging conducted 1 h post-injection, in conjunction with delayed imaging performed 3 h post-injection, for differentiating between benign and malignant lesions in prostate cancer (PCa) patients. METHODS: A retrospective assessment was undertaken on 44 prostate cancer patients who had undergone both routine and delayed 68 Ga-PSMA PET/CT scans. Variations in SUVmax and SUVmean values in normal organs, primary prostate cancer sites, metastatic sites, and benign lesions were analyzed...
March 28, 2024: Abdominal Radiology
https://read.qxmd.com/read/38546484/steroid-versus-placebo-injections-and-wrist-splints-in-patients-with-carpal-tunnel-syndrome-a-systematic-review-and-network-meta-analysis
#9
JOURNAL ARTICLE
Ebubechi Adindu, Sina Ramtin, Ali Azarpay, David Ring, Teun Teunis
A network meta-analysis of randomized controlled trials compared the effectiveness of corticosteroid injections with placebo injections and wrist splints for carpal tunnel syndrome, focusing on symptom relief and median nerve conduction velocity. Within 3 months of the corticosteroid injection, there was a modest statistically significant difference in symptom relief compared to placebo injections and wrist splints, as measured by the Symptom Severity Subscore of the Boston Carpal Tunnel Questionnaire; however, this did not meet the minimum clinically important difference...
March 28, 2024: Journal of Hand Surgery, European Volume
https://read.qxmd.com/read/38546317/ultrasound-guided-mid-forearm-median-nerve-block-for-relief-of-carpal-tunnel-syndrome-pain-in-the-emergency-department-a-case-report
#10
JOURNAL ARTICLE
Daniel L Puebla, Ilya Luchitsky, Roman Montes De Oca, Michael Shalaby, Robert A Farrow
INTRODUCTION: Carpal tunnel syndrome (CTS) is a common complaint in the emergency department (ED) and accounts for approximately 90% of all peripheral neuropathies.6 Pain control from injection with corticosteroids into the carpal tunnel space is associated with multiple possible complications including atrophy, iatrogenic median nerve injury, and skin changes. Ultrasound (US)-guided mid-forearm median nerve block is an ED procedure that can be used to avoid direct injection into the carpal tunnel space...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546278/mesenchymal-stem-cells-alleviate-mouse-liver-fibrosis-by-inhibiting-pathogenic-function-of-intrahepatic-b-cells
#11
JOURNAL ARTICLE
Xudong Feng, Bing Feng, Jiahang Zhou, Jinfeng Yang, Qiaoling Pan, Jiong Yu, Dandan Shang, Lanjuan Li, Hongcui Cao
BACKGROUND AIMS: The immunomodulatory characteristics of mesenchymal stem cells (MSCs) make them a promising therapeutic approach for liver fibrosis (LF). Here, we postulated that MSCs could potentially suppress the pro-fibrotic activity of intrahepatic B cells, thereby inhibiting LF progression. APPROACH RESULTS: Administration of MSCs significantly ameliorated LF as indicated by reduced myofibroblast activation, collagen deposition, and inflammation. The treatment efficacy of MSCs can be attributed to decreased infiltration, activation, and pro-inflammatory cytokine production of intrahepatic B cells...
March 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38546220/safety-efficacy-and-biological-data-of-t-cell-enabling-oncolytic-adenovirus-tilt-123-in-advanced-solid-cancers-from-the-tunimo-monotherapy-phase-i-trial
#12
JOURNAL ARTICLE
Santeri A Pakola, Katriina J Peltola, James H A Clubb, Elise Jirovec, Lyna Haybout, Tatiana V Kudling, Tuomo Alanko, Riitta Korpisaari, Susanna Juteau, Marjut Jaakkola, Jorma Sormunen, Jukka Kemppainen, Annabrita Hemmes, Teijo Pellinen, Mirte van der Heijden, Dafne C A Quixabeira, Claudia Kistler, Suvi Sorsa, Riikka Havunen, Joao M Santos, Victor Cervera-Carrascon, Akseli E Hemminki
PURPOSE: TILT-123 (igrelimogene litadenorepvec) is an oncolytic adenovirus armed with tumor necrosis factor alpha and interleukin-2, designed to induce T-cell infiltration and cytotoxicity in solid tumors. PATIENTS AND METHODS: TUNIMO (NCT04695327) was a single-arm, multicenter phase I dose escalation trial designed to assess safety of TILT-123 in advanced solid cancers refractory to standard therapy. Patients received intravenous and intratumoral TILT-123. The primary endpoint was safety by adverse events (AEs), laboratory values, vital signs, and electrocardiograms...
March 28, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38546195/susceptibility-of-shellfish-aquaculture-species-in-the-chesapeake-bay-and-maryland-coastal-bays-to-ostreid-herpesvirus-1-microvariants
#13
JOURNAL ARTICLE
M L Kachmar, K S Reece, M V Agnew, H J Schreier, C A Burge
Ostreid herpesvirus 1 (OsHV-1) and its microvariants (µVars) cause economically devastating mass mortalities of oysters and pose a threat to the shellfish aquaculture industry globally. OsHV-1 outbreaks can cause up to 100% mortality in the Pacific oyster Crassostrea gigas. However, OsHV-1 and its variants have a broad host range and can infect at least 7 bivalve species, including bay scallops Argopecten irradians and eastern oysters C. virginica. Determining the susceptibility of economically and ecologically important bivalve species to OsHV-1 is critical for improving biosecurity and disease management to protect the aquaculture industry...
March 14, 2024: Diseases of Aquatic Organisms
https://read.qxmd.com/read/38546152/transitioning-from-injectable-resin-composite-restorations-to-resin-composite-cad-cam-veneers-a-clinical-report
#14
JOURNAL ARTICLE
Niyousha Rafeie, Camila S Sampaio, Ronaldo Hirata
OBJECTIVE: To describe a shift from injectable resin composite technique to composite resin computer-aided design and computer-aided manufacturing (CAD/CAM) veneers in addressing esthetic concerns associated with diastemas between anterior lower teeth in a clinical case. CLINICAL CONSIDERATIONS: Among several techniques proposed for direct resin composite restoration, the "Injectable resin composite technique" has gained popularity for its time-efficiency, reduced technique sensitivity, and diminished reliance on clinician skills...
March 28, 2024: Journal of Esthetic and Restorative Dentistry
https://read.qxmd.com/read/38546137/understanding-exososmes-part-3-therapeutic-diagnostic-potential-in-dentistry
#15
REVIEW
Richard J Miron, Nathan E Estrin, Anton Sculean, Yufeng Zhang
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of various diseases. Over 5000 publications are currently being published on this topic yearly, many of which in the dental space. This extensive review article is the first scoping review aimed at summarizing all therapeutic uses of exosomes in regenerative dentistry...
March 28, 2024: Periodontology 2000
https://read.qxmd.com/read/38546103/effect-of-photobiomodulation-therapy-as-a-multimodal-approach-to-treatment-of-dermal-abrasions-in-cownose-rays-rhinoptera-bonasus
#16
JOURNAL ARTICLE
Anne L Gilewski, Jennifer E Flower, Lisa Miller, Allison D Tuttle
Photobiomodulation therapy (PBMT) has become increasingly utilized in the zoo and aquarium fields to treat ailments in various species; however, its use in teleosts and elasmobranchs is relatively underrepresented in the literature. This study examined the efficacy of PBMT as an adjunct treatment to reduce the healing time of dermal abrasions in cownose rays (Rhinoptera bonasus). Ten cownose rays were included in this study and separated into control (n = 5) and treatment groups (n = 5)...
March 28, 2024: Zoo Biology
https://read.qxmd.com/read/38546015/facet-dependent-photoluminescence-blinking-from-perovskite-nanocrystals
#17
JOURNAL ARTICLE
Mrinal Kanti Panda, Debopam Acharjee, Asit Baran Mahato, Subhadip Ghosh
Photoluminescence (PL) blinking of nanoparticles, while detrimental to their imaging applications, may benefit next-generation displays if the blinking is precisely controlled by reversible electron/hole injections from an external source. Considerable efforts are made to create well-characterized charged excitons within nanoparticles through electrochemical charging, which has led to enhanced control over PL-blinking in numerous instances. Manipulating the photocharging/discharging rates in nanoparticles by surface engineering can represent a straightforward method for regulating their blinking behaviors, an area largely unexplored for perovskite nanocrystals (PNCs)...
March 28, 2024: Small
https://read.qxmd.com/read/38545952/development-of-injectable-upconversion-nanoparticle-conjugated-doxorubicin-theranostics-electrospun-nanostructure-for-targeted-photochemotherapy-in-breast-cancer
#18
JOURNAL ARTICLE
Amreen Khan, Abhishek Tripathi, Mayuri Gandhi, Jayesh Bellare, Rohit Srivastava
Nanotheranostic-based photochemotherapies with targeted drug delivery have considerably surfaced in cancer therapy. In the presented work, polyethyleneimine-coated upconversion nanoparticles were engineered to conjugate covalently with doxorubicin. Upconversion nanoparticles (UCNP)-Doxorubicin (DOX)/synthesized epidermal growth factor receptor-targeting peptide blended with polymer composite was electrospun and formulated as the injectable dosage form. The size of the UCNP and the nanofiber diameter were assessed as 26...
March 28, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38545904/chondrocyte-targeted-delivery-system-of-sortase-a-engineered-extracellular-vesicles-silencing-mmp13-for-osteoarthritis-therapy
#19
JOURNAL ARTICLE
Wenjing Yan, Ying Li, Shuqian Xie, W Andy, Jing Hu, Haohan Liu, Guiyuan Zhang, Fengying Liu, Yamei Nie, Xue Chen, Xing Zhang, Yufeng Liu, Dong Wei, Changyan Ma, Hao Zhang, Hongtao Xu, Shizhi Wang
Targeted drug delivery and the reduction of off-target effects are crucial for the promising clinical application of nucleic acid drugs. To address this challenge, we developed a new approach for treating osteoarthritis (OA) that accurately delivers antisense oligonucleotides (ASO) targeting matrix metalloproteinase-13 (ASO-MMP13) to chondrocytes. Small extracellular vesicles (exos) were ligated with chondrocyte affinity peptide (CAP) using Sortase A and subsequently incubated with cholesterol-modified ASO-MMP13 to construct a chondrocyte-targeted drug delivery exo (CAP-exoASO)...
March 28, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38545854/safety-pharmacokinetics-and-pharmacodynamics-of-anti-il-4r%C3%AE-antibody-shr-1819-in-healthy-subjects-a-randomized-controlled-phase-i-study
#20
JOURNAL ARTICLE
Na Li, Sepehr Shakib, Weilin Qian, Xiaoyan Yao, Puyuan Li, Tsz Keung Nip, Xiaoyan Bai, Kai Shen
SHR-1819 is a novel anti-IL-4Rα monoclonal antibody currently under clinical development for use in patients with type 2 inflammatory diseases. In this randomized, double-blind, placebo-controlled, single-dose escalation phase I trial, we evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of SHR-1819 in healthy subjects. Subjects received a single subcutaneous injection of SHR-1819 or placebo, with dose escalation starting at 60 mg and subsequently increasing to 120, 240, 360, and 720 mg...
April 2024: Clinical and Translational Science
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