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L Z Zhou, S Fu, S Q Gao
Objective: To establish a method for determination trace bismuth in blood by atomic fluorescence spectrometry (AFS) . Methods: 4.0 ml nitric acid and 1.0 ml perchloric acid was added into 1.0 ml blood sample then through automation graphite digestion instrument digested, after that 1.0 ml thiocarbamide-vitamin (10%) was injected, 8% HCl constant volume to 10.0 ml, the bismuth was detected by atomic fluorescence spectrometry with 5.0 ml digestive sample. Results: The method showed a linear relationship within the range of 0...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Sergey V Kravchenko, Egor V Byzov, Mikhail A Moiseev, Leonid L Doskolovich
The development of LED secondary optics for road illumination is quite a challenging problem. Optical elements developed for this kind of application should have maximal efficiency, provide high luminance and illuminance uniformity, and meet many other specific requirements. Here, we demonstrate that the usage of the supporting quadric method modification enables generating free-form optical solution satisfying all these requirements perfectly. As an example, two optical elements for different roadway types are computed, manufactured by injection molding, and then measured in a photometry bench...
February 20, 2017: Optics Express
Niall P Kelly, Ludovic Caro, Mohamad Dernaika, Frank H Peters
Optical injection locking was used to red shift an integrated semiconductor laser up to 30 nm away from the main free running lasing mode. This injection locking of the laser beyond its band edge enabled its integration with an electroabsorption modulator to produce a 2.5 Gb/s eye diagram. The electroabsorption modulator was shown to have a 3 dB bandwidth of 5.5 GHz, which was limited by the contact capacitance. This paper demonstrates that such devices could be applied in a regrowth free, monolithic coherent wavelength division multiplexing transmitter...
February 20, 2017: Optics Express
Justin Norman, M J Kennedy, Jennifer Selvidge, Qiang Li, Yating Wan, Alan Y Liu, Patrick G Callahan, McLean P Echlin, Tresa M Pollock, Kei May Lau, Arthur C Gossard, John E Bowers
High performance III-V lasers at datacom and telecom wavelengths on on-axis (001) Si are needed for scalable datacenter interconnect technologies. We demonstrate electrically injected quantum dot lasers grown on on-axis (001) Si patterned with {111} v-grooves lying in the [110] direction. No additional Ge buffers or substrate miscut was used. The active region consists of five InAs/InGaAs dot-in-a-well layers. We achieve continuous wave lasing with thresholds as low as 36 mA and operation up to 80°C.
February 20, 2017: Optics Express
Stacy J Kowsz, Erin C Young, Benjamin P Yonkee, Christopher D Pynn, Robert M Farrell, James S Speck, Steven P DenBaars, Shuji Nakamura
We report a device that monolithically integrates optically pumped (20-21) III-nitride quantum wells (QWs) with 560 nm emission on top of electrically injected QWs with 450 nm emission. The higher temperature growth of the blue light-emitting diode (LED) was performed first, which prevented thermal damage to the higher indium content InGaN of the optically pumped QWs. A tunnel junction (TJ) was incorporated between the optically pumped and electrically injected QWs; this TJ enabled current spreading in the buried LED...
February 20, 2017: Optics Express
Bin Wang, Xinyu Fan, Shuai Wang, Jiangbing Du, Zuyuan He
In this paper, we propose and demonstrate a millimeter-resolution long-range optical frequency domain reflectometry (OFDR) using an ultra-linearly 100-GHz swept optical source realized by injection-locking technique and cascaded four-wave-mixing (FWM) process. The ultra-linear sweep is realized using an external modulation method with a linearly swept radio frequency (RF) signal. The RF signal sweeps from 16 GHz to 19.3 GHz, and the slave laser is injection-locked to the 8th-order sideband of the master laser, achieving a frequency sweeping span of ~25 GHz...
February 20, 2017: Optics Express
Mikio Fujiwara, Ryota Wakabayashi, Masahide Sasaki, Masahiro Takeoka
We report a wavelength division multiplexed time-bin entangled photon pair source in telecom wavelength using a 10 μm radius Si ring resonator. This compact resonator has two add ports and two drop ports. By pumping one add port by a continuous laser, we demonstrate an efficient generation of two-wavelength division multiplexed time-bin entangled photon pairs in the telecom C-band, which come out of one drop port, and are then split into the signal and idler photons via a wavelength filter. The resonator structure enhances four-wave mixing for pair generation...
February 20, 2017: Optics Express
Caroline H Reid, Niall J Finnerty
We describe the in vivo characterization of microamperometric sensors for the real-time monitoring of nitric oxide (NO) and oxygen (O₂) in the striatum of immunocompromised NOD SCID mice. The latter strain has been utilized routinely in the establishment of humanized models of disease e.g., Parkinson's disease. NOD SCID mice were implanted with highly sensitive and selective NO and O₂ sensors that have been previously characterized both in vitro and in freely moving rats. Animals were systemically administered compounds that perturbed the amperometric current and confirmed sensor performance...
February 22, 2017: Sensors
Sandra Petrus-Reurer, Hammurabi Bartuma, Monica Aronsson, Sofie Westman, Fredrik Lanner, Helder André, Anders Kvanta
Purpose: Subretinal suspension transplants of human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) have the capacity to form functional monolayers in naive eyes. We explore hESC-RPE integration when transplanted in suspension to a large-eyed model of geographic atrophy (GA). Methods: Derivation of hESC-RPE was performed in a xeno-free and defined manner. Subretinal bleb injection of PBS or sodium iodate (NaIO3) was used to induce a GA-like phenotype...
February 1, 2017: Investigative Ophthalmology & Visual Science
Sean F Hackett, Christopher Seidel, Sheena Abraham, Rishi Chadha, Seth D Fortmann, Peter A Campochiaro, John P Cooke
Purpose: To investigate the role of nicotinic acetylcholine receptors (nAChRs) in retinal vascular development and ischemia-induced retinal neovascularization (NV). Methods: The expression of nAChR subtypes and VEGF signaling pathway components was assessed in mice with and without oxygen-induced ischemic retinopathy by comparing expression levels at postnatal day (P) 14 and P17 in mice exposed to 75% oxygen from P7 to P12 and returned to room air versus mice pups that were exposed to ambient oxygen levels during the same period...
February 1, 2017: Investigative Ophthalmology & Visual Science
Marie Fukami, Takeshi Iwase, Kentaro Yamamoto, Hiroki Kaneko, Shunsuke Yasuda, Hiroko Terasaki
Purpose: To evaluate the effects of an intravitreal ranibizumab (IVR) injection on the retinal microcirculation of eyes with macular edema secondary to a branch retinal vein occlusion (BRVO). Methods: Twenty-six eyes of 26 patients with macular edema due to a BRVO that had received a single IVR injection (0.5 mg/0.05 mL) were studied. The retinal microcirculation was assessed by laser speckle flowgraphy (LSFG) using the mean blur rate (MBR) and relative flow volume (RFV)...
February 1, 2017: Investigative Ophthalmology & Visual Science
Manas R Biswal, Pingyang Han, Ping Zhu, Zhaoyang Wang, Hong Li, Cristhian J Ildefonso, Alfred S Lewin
Purpose: To investigate whether antioxidant gene therapy protects the structure and function of retina in a murine model of RPE atrophy, and to determine whether antioxidant gene therapy can prevent degeneration once it has begun. Methods: We induced mitochondrial oxidative stress in RPE by conditional deletion of Sod2, the gene for manganese superoxide dismutase (MnSOD). These mice exhibited localized atrophy of the RPE and overlying photoreceptors. We restored Sod2 to the RPE of one eye using adeno-associated virus (AAV) by subretinal injection at an early (6 weeks) and a late stage (6 months), injecting the other eye with an AAV vector expressing green fluorescent protein (GFP)...
February 1, 2017: Investigative Ophthalmology & Visual Science
Tomomi Masuda, Masamitsu Shimazawa, Yuhei Hashimoto, Atsushi Kojima, Shinsuke Nakamura, Shinsuke Suemori, Kiyofumi Mochizuki, Hideaki Kawakami, Kazuhide Kawase, Hideaki Hara
Purpose: To determine the relationship between the different isoforms of apolipoprotein E (ApoE) and retinal neovascularization. Methods: The concentrations of ApoE and VEGF in vitreous humor samples with either a macular hole (MH), or diabetic macular edema (DME), or proliferative diabetic retinopathy (PDR) with or without intravitreal injection of bevacizumab (IVB) were measured by ELISA. The effects of each isoform of ApoE on human retinal microvascular endothelial cells (HRMECs) in culture or on the retina of oxygen-induced retinopathy (OIR) mice were investigated...
February 1, 2017: Investigative Ophthalmology & Visual Science
T Craig Cheetham, JaeJin An, Steven J Jacobsen, Fang Niu, Stephen Sidney, Charles P Quesenberry, Stephen K VanDenEeden
Importance: Controversy exists regarding the safety of testosterone replacement therapy (TRT) following recent reports of an increased risk of adverse cardiovascular events. Objective: To investigate the association between TRT and cardiovascular outcomes in men with androgen deficiency. Design, Setting, and Participants: A retrospective cohort study was conducted within an integrated health care delivery system. Men at least 40 years old with evidence of androgen deficiency either by a coded diagnosis and/or a morning serum total testosterone level of less than 300 ng/dL were included...
February 21, 2017: JAMA Internal Medicine
Aaron J Feinstein, Alex Goel, Govind Raghavan, Jennifer Long, Dinesh K Chhetri, Gerald S Berke, Abie H Mendelsohn
Importance: Optimal management of subglottic stenosis has not been established. Endoscopic techniques include balloon dilation, radial incisions with carbon dioxide laser or cold knife, and combinations of techniques. Adjunctive measures include mitomycin application and glucocorticoid injection. Objective: To determine whether surgical technique or adjunctive measures are associated with duration between surgical procedures. Design, Setting, and Participants: Adult patients with subglottic stenosis treated endoscopically between 1995-2015 at a quaternary academic medical center were identified...
February 23, 2017: JAMA Otolaryngology—Head & Neck Surgery
Shinji Miwa, Hideji Nishida, Yoshikazu Tanzawa, Akihiko Takeuchi, Katsuhiro Hayashi, Norio Yamamoto, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko, Hiroyuki Tsuchiya
BACKGROUND: There are limited options for the curative treatment of refractory bone and soft tissue sarcomas. The purpose of this phase 1/2 study was to assess the immunological and clinical effects of dendritic cells (DCs) pulsed with autologous tumor lysate (TL) in patients with advanced bone and soft tissue sarcomas. METHODS: Thirty-seven patients with metastatic or recurrent sarcomas were enrolled in this study. Peripheral blood mononuclear cells obtained from the patients were suspended in media containing interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor...
February 27, 2017: Cancer
Cao Cui, Zhen Yang, Xiang Hu, Jinjun Wu, Kangquan Shou, Hengheng Ma, Chao Jian, Yong Zhao, Baiwen Qi, Xiaoming Hu, Aixi Yu, Quli Fan
Acute Venous thrombosis is prevalent and potentially fatal. Accurate diagnosis of early thrombus is needed for patients in timely clinical intervention to prevent life-threatening conditions. Photoacoustic imaging (PAI) with excellent spatial resolution and high optical contrast shows more promising for this purpose. However, its application is dramatically limited by its signal-off effect on thrombus because of the ischemia in thrombus which lacks endogenous photoacoustic (PA) signal of haemoglobin. To address this dilemma, we herein report the feasibility of using organic semiconducting NPs for contrast-enhanced PAI of thrombus in living mice...
February 27, 2017: ACS Nano
Philipp V Schwaninger, Sandra E Mueller, Rebecca Dittmann, Renanto Poespodihardjo, Marc Vogel, Gerhard A Wiesbeck, Marc Walter, Sylvie A Petitjean
BACKGROUND AND OBJECTIVES: Exposure to traumatic events is common among patients with substance use disorders (SUD). In patients with non-substance-related disorders, especially with gambling disorders (GD) and internet addiction (IA), traumatic childhood experiences have not been investigated extensively. The objective of this study was to compare trauma histories in patients with GD and IA to patients with heroin dependence. METHODS: Cross-sectional surveys including the childhood trauma questionnaire (CTQ) and clinical data among 107 participants; 59 patients with non-substance-related disorders (GD [n = 39]; IA [n = 20]) were compared to 28 patients prescribed injectable heroin for opioid dependence in heroin-assisted treatment (HAT) and to a healthy control group (HC) (n = 20)...
February 27, 2017: American Journal on Addictions
P Persiani, F M Ranaldi, O Mazza, A Calistri, M Bove, M Crostelli, C Villani
INTRODUCTION: Osteoarticular infections are found frequently in drug addicted individuals, representing one of the main reasons for their hospitalization. Through inoculation, the pathogenic agents can enter the individual's system directly through the skin or parenterally, transmitted, that is, through syringes and other objects used during such practice. In these particular conditions, or when the medical history is vague, a warranted suspicion and the execution of targeted research can help in the diagnosis of high-risk patients such as addicts...
January 2017: La Clinica Terapeutica
Roberto Andres Salas Fragomeni, Evrim B Turkbey, Blake C Jones, Lilja B Solnes, Steven P Rowe
The incidence of congenital heart disease requiring specialized care is 2.5 to 3 per 1000 live births with a prevalence of congenital heart disease of 81.4 per 10,000 live births. Total cavopulmonary or atriopulmonary connection, used for palliation of certain types of congenital heart disease, diverts flow from the vena cava or atrium directly into the pulmonary arteries. Altered anatomy in patients who have undergone this intervention may result in contrast and/or radiotracer localizing preferentially to a single lung leading to interpretation errors and redundant studies...
February 24, 2017: Clinical Nuclear Medicine
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