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n/l ratio

David L Carey, Kay M Crossley, Rod Whiteley, Andrea Mosler, Kok-Leong Ong, Justin Crow, Meg E Morris
PURPOSE: To evaluate common modelling strategies in training load and injury risk research when modelling continuous variables and interpreting continuous risk estimates; and present improved modelling strategies. METHOD: Workload data were pooled from Australian football (n=2,550) and soccer (n=23,742) populations to create a representative sample of acute:chronic workload ratio observations for team sports. Injuries were simulated in the data using three pre-defined risk profiles (U-shaped, flat and S-shaped)...
June 21, 2018: Medicine and Science in Sports and Exercise
Eugene M Dunne, Catherine W Striley, Zachary L Mannes, Breton M Asken, Nicole E Whitehead, Linda B Cottler
OBJECTIVE: Prescription opioid misuse has become a significant public health issue. Previous research has examined predictors of prescription opioid use and misuse among former National Football League (NFL) players. The present study aimed to describe how reasons for prescription opioid use while in the NFL corresponds to use and misuse in retirement. DESIGN: Former NFL players reporting prescription opioid use during their playing careers (N = 336) were included in this secondary data analysis...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
David R Howell, Anna N Brilliant, Christina L Master, William P Meehan
OBJECTIVE: To determine the test-retest correlation of an objective eye-tracking device among uninjured youth athletes. DESIGN: Repeated-measures study. SETTING: Sports-medicine clinic. PARTICIPANTS: Healthy youth athletes (mean age = 14.6 ± 2.2 years; 39% women) completed a brief, automated, and objective eye-tracking assessment. INDEPENDENT VARIABLES: Participants completed the eye-tracking assessment at 2 different testing sessions...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Prithwish Mahapatra, Michael G B Drew, Ashutosh Ghosh
A new mononuclear Ni(II) complex [NiL] (1) of an unsymmetrically dicondensed N2 O3 donor ligand, H2 L ( N-α-methylsalicylidene- N'-3-methoxysalicylidene-1,3-propanediamine), has been synthesized. Complex 1 on reaction with Mn(ClO4 )2 ·6H2 O and NaN3 in different molar ratios yielded three novel heterometallic NiII -MnII complexes, [(NiL)2 Mn(N3 )](ClO4 ) (2), [(NiL)2 Mn2 (N3 )2 (μ1,1 -N3 )2 (CH3 OH)2 ] (3), and [{(NiL)2 Mn}2 (μ1,3 -N3 )(H2 O)]·(CH3 OH),(ClO4 )3 (4). The single crystal structure analyses show a trinuclear NiII 2 MnII structure for complex 2 and a tetranuclear NiII 2 MnII 2 structure where two dinuclear NiII MnII units are connected via μ1,1 -azido and phenoxido bridges for complex 3...
June 22, 2018: Inorganic Chemistry
C E M Aiken, L Hone, H R Murphy, C L Meek
AIM: Excessive gestational weight gain increases risk of gestational diabetes mellitus (GDM) but it remains unclear whether weight control after GDM diagnosis improves outcomes. We assessed whether: (1) total gestational weight gain during pregnancy (0-36 weeks); (2) early gestational weight gain (0-28 weeks, before GDM diagnosis); or (3) late gestational weight gain (28-36 weeks, after diagnosis) are associated with maternal-fetal outcomes. METHODS: Some 546 women with GDM who delivered viable singleton infants at a single UK obstetric centre (October 2014 to March 2017) were included in this retrospective observational study...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Sebastian Wilde, Dongxin Ma, Tobias Koch, Anne Bakker, Dario Gonzalez-Abradelo, Linda Stegemann, Constantin G Daniliuc, Harald Fuchs, Hongying Gao, Nikos L Doltsinis, Lian Duan, Cristian A Strassert
The synthesis of new Pt(II) complexes bearing tailored cyclometalated C^N*N^C luminophores is reported along with their photophysical properties. The emission of the monomeric species can be blue shifted upon formal isosteric replacement of two C-H units by N atoms at the two cyclometalating rings. Their remarkable stability upon sublimation was demonstrated by means of scanning tunneling microscopy, which also revealed a defined self-assembly behavior leading to supramolecular arrays, showing a 3-fold symmetry in 2D-confined monolayers...
June 22, 2018: ACS Applied Materials & Interfaces
Irja Ventä, Miira M Vehkalahti, Anna L Suominen
OBJECTIVES: The aim of the study was to characterize third molars that have remained disease-free in a representative sample of the Finnish population aged 30 years and older. MATERIALS AND METHODS: Two-staged stratified cluster sampling (N = 8028) was used, and 6005 subjects participated in a clinical oral examination and panoramic radiography. Disease-free third molars were characterized as follows: no dentinal caries, no filling, periodontal pocket depths of neighboring second molars less than 4 mm, and no radiographic pathological findings...
June 21, 2018: Clinical Oral Investigations
Minouk J Schoemaker, Hazel B Nichols, Lauren B Wright, Mark N Brook, Michael E Jones, Katie M O'Brien, Hans-Olov Adami, Laura Baglietto, Leslie Bernstein, Kimberly A Bertrand, Marie-Christine Boutron-Ruault, Tonje Braaten, Yu Chen, Avonne E Connor, Miren Dorronsoro, Laure Dossus, A Heather Eliassen, Graham G Giles, Susan E Hankinson, Rudolf Kaaks, Timothy J Key, Victoria A Kirsh, Cari M Kitahara, Woon-Puay Koh, Susanna C Larsson, Martha S Linet, Huiyan Ma, Giovanna Masala, Melissa A Merritt, Roger L Milne, Kim Overvad, Kotaro Ozasa, Julie R Palmer, Petra H Peeters, Elio Riboli, Thomas E Rohan, Atsuko Sadakane, Malin Sund, Rulla M Tamimi, Antonia Trichopoulou, Giske Ursin, Lars Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter C Willett, Alicja Wolk, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Dale P Sandler, Anthony J Swerdlow
Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation. Objective: To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics...
June 21, 2018: JAMA Oncology
Robert L Ferris, Nabil F Saba, Barbara J Gitlitz, Robert Haddad, Ammar Sukari, Prakash Neupane, John C Morris, Krzysztof Misiukiewicz, Julie E Bauman, Moon Fenton, Antonio Jimeno, Douglas R Adkins, Charles J Schneider, Assuntina G Sacco, Keisuke Shirai, Daniel W Bowles, Michael Gibson, Tobenna Nwizu, Raphael Gottardo, Kristi L Manjarrez, Gregory N Dietsch, James Kyle Bryan, Robert M Hershberg, Ezra E W Cohen
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To determine whether motolimod improves outcomes for R/M SCCHN when combined with standard therapy. Design, Setting, and Participants: The Active8 study was a multicenter, randomized, double-blind, placebo-controlled clinical trial enrolling adult patients (age ≥18 years) with histologically confirmed R/M SCCHN of the oral cavity, oropharynx, hypopharynx, or larynx between October 2013 and August 2015...
June 21, 2018: JAMA Oncology
Yanan Liu, Mark Paterson, Shelley L Baumgardt, Michael G Irwin, Zhengyuan Xia, Zeljko J Bosnjak, Zhi-Dong Ge
Aims: Previous studies indicate that nitric oxide derived from endothelial nitric oxide synthase (eNOS) serves as both trigger and mediator in anesthetic cardiac preconditioning. The mechanisms underlying regulation of eNOS by volatile anesthetics have not been fully understood. Therefore, this study examined the role of vascular endothelial growth factor (VEGF) in isoflurane cardiac preconditioning. Methods and results: Wistar rats underwent 30 min of coronary artery occlusion followed by 2 h of reperfusion...
June 21, 2018: Cardiovascular Research
Y Q Si, X Tang, D D Zhang, L He, Y Cao, J W Wang, N Li, J J Liu, P Gao, Y H Hu
OBJECTIVE: To estimate the potential health benefit of screening strategies for cardiovascular diseases primary prevention in a rural northern Chinese population. METHODS: A total of 6 221 adults aged 40-74 years old, from rural Beijing, China and free from cardiovascular diseases at baseline were included. The following screening strategies were compared: Strategy 1, the strategy based on numbers of risk factors recommended by the Chinese Guideline for Prevention of Cardiovascular Diseases in people aged 40-74; Strategy 2, screening people aged 40-74 based on the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) risk prediction model; Strategy 3, screening people aged 50-74 using the China-PAR risk prediction model...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Susitha Wanigaratne, Pamela Uppal, Manvir Bhangoo, Alia Januwalla, Deepa Singal, Marcelo L Urquia
BACKGROUND: Son-biased sex ratios at birth (M:F), an extreme manifestation of son preference, are predominately found in East and South Asia. Studies have examined sex ratios among first-generation migrants from these regions, but few have examined second-generation descendants. Our objective was to determine whether son-biased sex ratios persist among second-generation mothers with South Asian ethnicity in Ontario, Canada. METHODOLOGY: A surname algorithm identified a population-based cohort of mothers with South Asian ethnicity who gave birth in Ontario between 1993 and 2014 (n=59 659)...
June 21, 2018: Journal of Epidemiology and Community Health
Trine Munk-Olsen, Xiaoqin Liu, Alexander Viktorin, Hilary K Brown, Arianna Di Florio, Brian M D'Onofrio, Tara Gomes, Louise M Howard, Hind Khalifeh, Holly Krohn, Henrik Larsson, Paul Lichtenstein, Clare L Taylor, Inge Van Kamp, Richard Wesseloo, Samantha Meltzer-Brody, Simone N Vigod, Veerle Bergink
BACKGROUND: Concerns about teratogenicity and maternal and offspring complications restrict the use of lithium during pregnancy for the treatment of mood disorders. We aimed to investigate the association between in-utero lithium exposure and risk of pregnancy complications, delivery outcomes, neonatal morbidity, and congenital malformations. METHODS: In this meta-analysis, primary data from pregnant women and their children from six international cohorts based in the community (Denmark, Sweden, and Ontario, Canada) and in clinics (the Netherlands, UK, and USA) were analysed...
June 18, 2018: Lancet Psychiatry
Wanfeng Wang, Jun Wang, Yanling Guo, Chunyou Zhu, Feng Pan, Ruijie Wu, Chunfeng Wang
Due to their significant absorption and reduction abilities, nanoscale zero-valent iron (nZVI)/granular activated carbon (GAC) composites are very effective for the degradation of organic contaminants and heavy metals. However, to date, there is no systematic study on the applicability of nZVI/GAC for the removal of multiple highly toxic nitrosamines from water supplies. For this study, nZVI/GAC was synthesized and applied to the degradation of multiple nitrosamines. The effects of initial nitrosamine concentration, composite dosage, contact duration, competition with coexistent elements, and reaction mechanisms during the nitrosamine removal process from aqueous solutions were investigated...
October 15, 2018: Science of the Total Environment
Y H Yu, L Doucette-Stamm, J Rogus, K Moss, R Y L Zee, B Steffensen, P M Ridker, J E Buring, S Offenbacher, K Kornman, D I Chasman
Periodontal disease (PD) shares common risk factors with cardiovascular disease. Our hypothesis was that having a family history of myocardial infarction (FamHxMI) may be a novel risk factor for PD. Risk assessment based on FamHxMI, conditional on smoking status, was examined given the strong influence of smoking on PD. Exploratory analysis with inflammatory biomarkers and genetic determinants was conducted to understand potential mechanistic links. The Women's Genome Health Study (WGHS) is a prospective cohort of US female health care professionals who provided blood samples at baseline in the Women's Health Study, a 2 × 2 factorial clinical trial investigating vitamin E and aspirin in the prevention of cardiovascular disease and cancer...
June 1, 2018: Journal of Dental Research
Laura E Miller-Graff, Azza H Ahmed, Julia L Paulson
BACKGROUND: Intimate partner violence has been related to breastfeeding difficulties. Few studies, however, have also accounted for other biopsychosocial risk factors associated with women's breastfeeding. Research aim: This study aimed to examine how prenatal intimate partner violence affects women's breastfeeding initiation, early cessation, and exclusivity at 6 weeks postpartum, controlling for perinatal health problems, prenatal depression, childhood adverse experiences, and prenatal breastfeeding education...
June 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Jiri Gallo, Michal Svoboda, Jana Zapletalova, Jitka Proskova, Jarmila Juranova
BACKGROUND: The diagnosis of prosthetic joint infection (PJI) is still a challenge in some patients after total joint replacement. Interleukin-6 (IL-6) strongly participates in the arrangement of the host-bacteria response. Therefore, increased levels of IL-6 should accompany every PJI. PURPOSE: The aim of the study was to show diagnostic characteristics of serum IL-6 for the diagnosis of prosthetic joint infection (PJI). We also compared the diagnostic values of serum IL-6 with synovial IL-6 (sIL-6) and synovial C-reactive protein (sCRP)...
2018: PloS One
Arun Saini, Alina N West, Camden Harrell, Tamekia L Jones, Marianne E Nellis, Ashwini D Joshi, Krista M Cowan, Connor W Gatewood, Alex B Ryder, Ulrike M Reiss
OBJECTIVES: Pediatric intensivists frequently prescribe platelet transfusions to critically ill children, but there are limited data on platelet transfusion practice and platelet transfusion-related outcomes in the PICU. In this study, we evaluated the current platelet transfusion practice and platelet transfusion-related outcomes in the PICU. DESIGN: Institutional review board-approved, retrospective cohort study from January 2010 to March 2016. SETTING: Tertiary-level PICU...
June 20, 2018: Pediatric Critical Care Medicine
J Düring, J Dankiewicz, T Cronberg, C Hassager, J Hovdenes, J Kjaergaard, M Kuiper, N Nielsen, T Pellis, P Stammet, J Vulto, M Wanscher, M Wise, A Åneman, H Friberg
BACKGROUND: Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out-of-hospital cardiac arrest, results regarding outcome and lactate are conflicting. METHODS: This is a post-hoc analysis of the Target Temperature Management trial in which 950 unconscious patents after out-of-hospital cardiac arrest were randomized to a temperature intervention of 33°C or 36°C. Serial lactate samples during the first 36 hours were collected...
June 21, 2018: Acta Anaesthesiologica Scandinavica
F Nicastro, J Kaastra, Y Krongold, S Borgani, E Branchini, R Cen, M Dadina, C W Danforth, M Elvis, F Fiore, A Gupta, S Mathur, D Mayya, F Paerels, L Piro, D Rosa-Gonzalez, J Schaye, J M Shull, J Torres-Zafra, N Wijers, L Zappacosta
It has been known for decades that the observed number of baryons in the local Universe falls about 30-40 per cent short1,2 of the total number of baryons predicted 3 by Big Bang nucleosynthesis, as inferred4,5 from density fluctuations of the cosmic microwave background and seen during the first 2-3 billion years of the Universe in the so-called 'Lyman α forest'6,7 (a dense series of intervening H I Lyman α absorption lines in the optical spectra of background quasars). A theoretical solution to this paradox locates the missing baryons in the hot and tenuous filamentary gas between galaxies, known as the warm-hot intergalactic medium...
June 2018: Nature
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