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https://www.readbyqxmd.com/read/29454138/prognostic-implications-of-early-monomorphic-and-non-monomorphic-tachyarrhythmias-in-patients-discharged-with-acute-coronary-syndrome
#1
Jo-Jo Hai, Ka-Chun Un, Chun-Ka Wong, Ka-Lam Wong, Zhe-Yu Zhang, Pak-Hei Chan, Chu-Pak Lau, Chung-Wah Siu, Hung-Fat Tse
BACKGROUND: The prognostic implication of early ventricular tachycarrhythmias (VT) after acute coronary syndrome (ACS) remains unclear. OBJECTIVE: We sought to investigate the clinical outcomes of early monomorphic and non-monomorphic VT that occur within 48 hours in patients after ACS. METHODS: We retrospectively reviewed the clinical outcomes of 2033 (mean age: 67.0±13.4 years, 73.1% male) consecutive patients who presented with ACS from 2004 to 2015...
February 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29453744/low-serum-ige-is-a-sensitive-and-specific-marker-for-common-variable-immunodeficiency-cvid
#2
Monica G Lawrence, Thamiris V Palacios-Kibler, Lisa J Workman, Alexander J Schuyler, John W Steinke, Spencer C Payne, Emily C McGowan, James Patrie, Ramsay L Fuleihan, Kathleen E Sullivan, Patricia L Lugar, Camellia L Hernandez, Douglas E Beakes, James W Verbsky, Thomas A E Platts-Mills, Charlotte Cunningham-Rundles, John M Routes, Larry Borish
Although small prior studies have suggested that IgE can be low in common variable immunodeficiency (CVID), the workup for patients with recurrent infections and suspected hypogammaglobulinemia does not include the routine measurement of serum IgE. We sought to test the hypothesis that low/undetectable serum IgE is characteristic of CVID by comparing the frequency of low/undetectable serum IgE in healthy controls and patients with CVID. We measured total serum IgE in a large multi-center cohort of patients with CVID (n = 354) and compared this to large population-based cohorts of children and adults...
February 17, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29453721/fenton-treatment-of-bio-treated-fermentation-based-pharmaceutical-wastewater-removal-and-conversion-of-organic-pollutants-as-well-as-estimation-of-operational-costs
#3
Yunqin Cheng, Yunlu Chen, Juncheng Lu, Jianxin Nie, Yan Liu
The Fenton process is used as a tertiary treatment to remove organic pollutants from the effluent of bio-treated pharmaceutical wastewater (EBPW). The optimal and most appropriate Fenton conditions were determined by an orthogonal array test and single-factor experiments. The removal of chemical oxygen demand (COD) was influenced by the following factors in a descending order: H 2 O 2 /Fe(II) molar ratio > H 2 O 2 dosage > reaction time. Under the most appropriate Fenton conditions (H 2 O 2 /Fe(II) molar ratio of 1:1, H 2 O 2 dosage of 120 mg L -1 and reaction time of 10 min), the COD and dissolved organic carbon (DOC) were removed with efficiencies of 62 and 53%, respectively, which met the national discharge standard (GB 21903-2008) for the Lake Tai Basin, China...
February 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29453671/comparative-evaluation-of-pharmacokinetics-and-pharmacodynamics-of-insulin-glargine-glaritus-%C3%A2-and-lantus-%C3%A2-in-healthy-subjects-a-double-blind-randomized-clamp-study
#4
Ashima Bhatia, Shraddha Tawade, Mushtaque Mastim, Eliford Ngaimisi Kitabi, Mathangi Gopalakrishnan, Manish Shah, Sridhar Yeshamaina, Joga Gobburu, Maharaj Sahib, Dipak Thakur, K M Prasanna Kumar
AIMS: The objective of the study was to compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties of an insulin glargine formulation, Glaritus ® (test) with the innovator's formulation Lantus ® (reference) using the euglycemic clamp technique in a single-dose, double-blind, randomized, two sequences, four-period replicate crossover study in healthy volunteers (n = 40). METHODS: Subjects received subcutaneous administration of the insulin glargine (0...
February 16, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29453074/use-of-prostaglandin-f2%C3%AE-as-ovulatory-stimulus-for-synchronizing-dairy-cattle
#5
N A Castro, P M A Neves, J P Cestaro, V T O Melo, A Schneider, L F M Pfeifer
The aim of this study was to evaluate if prostaglandin F2α (PGF) can be used to induce ovulation in a GnRH-progesterone based protocol. In Experiment 1 crossbred dairy cows (n=32) were synchronized with a progesterone-GnRH based protocol for seven days, where the luteolytic dose of 150μg PGF was given 24h prior progesterone device removal (CIDR). On Day 8 cows were separated into two groups to receive: 1) 2mL of Saline (Control Group, n=15) or 2) 150μg of PGF (PGF Group, n=17). Ovulation rate was higher in the PGF than Control group (100% vs 53...
January 31, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29453023/implications-of-altered-maternal-cytokine-concentrations-on-infant-outcomes-in-children-with-prenatal-alcohol-exposure
#6
K D Sowell, J Y Uriu-Adams, J Van de Water, C D Chambers, C D Coles, J A Kable, L Yevtushok, N Zymak-Zakutnya, W Wertelecki, C L Keen
Excessive alcohol consumption has been shown to increase serum plasma levels of numerous immune cytokines. Maternal immune activation and elevated cytokines have been implicated in certain neurological disorders (e.g., autism and schizophrenia) in the offspring. We investigated the hypothesis that elevated cytokines during pregnancy are a risk factor in women who gave birth to a child with Fetal Alcohol Spectrum Disorder (FASD) or a child with neurobehavioral impairment, regardless of prenatal alcohol exposure...
August 12, 2017: Alcohol
https://www.readbyqxmd.com/read/29452959/differential-expressions-of-mdm2-and-tap73-in-cancer-and-cancer-adjacent-tissues-in-patients-with-non-small-cell-lung-carcinoma
#7
B Wang, X Liu, H Liu, J Guo, T Zhang, N Zhou, Y Ma, H Yu, L Chen, Z Ren, K Fan, X Tian
AIM: To investigate the differences in mRNA and protein expressions of MDM2 (mouse double minute 2 homolog) and P73 in cancer and cancer-adjacent tissues in patients with non-small-cell lung carcinoma (NSCLC). MATERIALS AND METHODS: We compared the protein expressions of MDM2 and P73 in lung cancer and cancer-adjacent tissues in NSCLC patients by IHC (immunohistochemistry) and WB (Western blot). We divided the NSCLC patients into two subgroups, adenocarcinoma and squamous carcinoma...
February 13, 2018: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29452832/delayed-endovascular-aortic-repair-is-associated-with-reduced-in-hospital-mortality-in-patients-with-blunt-thoracic-aortic-injury
#8
Christina L Marcaccio, Ryan P Dumas, Yanlan Huang, Wei Yang, Grace J Wang, Daniel N Holena
OBJECTIVE: The traditional approach to stable blunt thoracic aortic injury (BTAI) endorsed by the Society for Vascular Surgery is early (<24 hours) thoracic endovascular aortic repair (TEVAR). Recently, some studies have shown improved mortality in stable BTAI patients repaired in a delayed manner (≥24 hours). However, the indications for use of delayed TEVAR for BTAI are not well characterized, and its overall impact on the patient's survival remains poorly understood. We sought to determine whether delayed TEVAR is associated with a decrease in mortality compared with early TEVAR in this population...
February 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29452814/deep-or-awake-removal-of-laryngeal-mask-airway-in-children-at-risk-of-respiratory-adverse-events-undergoing-tonsillectomy-a-randomised-controlled-trial
#9
A Ramgolam, G L Hall, G Zhang, M Hegarty, B S von Ungern-Sternberg
BACKGROUND: Laryngeal mask airways (LMA) are widely used during tonsillectomies. Contrasting evidence exists regarding the timing of the removal and the risk of perioperative respiratory adverse events. We assessed whether the likelihood of perioperative respiratory adverse events is influenced by the timing of LMA removal in children with at least one risk factor for these events. METHODS: Participants (n=290, 0-16 yr) were randomised to have their LMA removed either deep (in theatre by anaesthetist at end-tidal sevoflurane >1 minimum alveolar concentration) or awake (in theatre by anaesthetist or in postanaesthesia care unit by anaesthetist or trained nurse)...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452813/incidence-characteristics-and-predictive-factors-for-medication-errors-in-paediatric-anaesthesia-a-prospective-incident-monitoring-study
#10
C Gariel, B Cogniat, F-P Desgranges, D Chassard, L Bouvet
BACKGROUND: Medication errors are not uncommon in hospitalized patients. Paediatric patients may have increased risk for medication errors related to complexity of weight-based dosing calculations or problems with drug preparation and dilution. This study aimed to determine the incidence of medication errors in paediatric anaesthesia in a university paediatric hospital, and to identify their characteristics and potential predictive factors. METHODS: This prospective incident monitoring study was conducted between November 2015 and January 2016 in an exclusively paediatric surgical centre...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29450462/epidemiology-of-adult-dsm-5-major-depressive-disorder-and-its-specifiers-in-the-united-states
#11
Deborah S Hasin, Aaron L Sarvet, Jacquelyn L Meyers, Tulshi D Saha, W June Ruan, Malka Stohl, Bridget F Grant
Importance: No US national data are available on the prevalence and correlates of DSM-5-defined major depressive disorder (MDD) or on MDD specifiers as defined in DSM-5. Objective: To present current nationally representative findings on the prevalence, correlates, psychiatric comorbidity, functioning, and treatment of DSM-5 MDD and initial information on the prevalence, severity, and treatment of DSM-5 MDD severity, anxious/distressed specifier, and mixed-features specifier, as well as cases that would have been characterized as bereavement in DSM-IV...
February 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29450433/a-novel-3-d-cuprous-iodide-polymer-with-a-high-cu-i-ratio
#12
Hong Xiao, Jian Zhou, Xing Liu, Hongping Xiao, Rute A S Ferreira, Luís D Carlos, Lianshe Fu
A novel 3-D cuprous iodide polymer [CuI(μ 6 -L)] n with a Cu/I ratio as high as 3 (1, H 2 L = 1,3-bis(2H-tetrazol-5-yl)benzene) has been hydrothermally synthesized. The 3-D framework of 1 is constructed by the linkages of rare 1-D cationic aggregates [CuI 2+ ] n and anionic bi-tetrazolate bridges. 1 shows unusually thermochromic luminescent and photocatalytic properties, and its density functional theory calculation has also been studied.
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29449192/association-of-body-mass-index-and-outcomes-in-patients-with-metastatic-melanoma-treated-with-targeted-therapy-immunotherapy-or-chemotherapy-a-retrospective-multicohort-analysis
#13
Jennifer L McQuade, Carrie R Daniel, Kenneth R Hess, Carmen Mak, Daniel Y Wang, Rajat R Rai, John J Park, Lauren E Haydu, Christine Spencer, Matthew Wongchenko, Stephen Lane, Dung-Yang Lee, Mathilde Kaper, Meredith McKean, Kathryn E Beckermann, Samuel M Rubinstein, Isabelle Rooney, Luna Musib, Nageshwar Budha, Jessie Hsu, Theodore S Nowicki, Alexandre Avila, Tomas Haas, Maneka Puligandla, Sandra Lee, Shenying Fang, Jennifer A Wargo, Jeffrey E Gershenwald, Jeffrey E Lee, Patrick Hwu, Paul B Chapman, Jeffrey A Sosman, Dirk Schadendorf, Jean-Jacques Grob, Keith T Flaherty, Dana Walker, Yibing Yan, Edward McKenna, Jeffrey J Legos, Matteo S Carlino, Antoni Ribas, John M Kirkwood, Georgina V Long, Douglas B Johnson, Alexander M Menzies, Michael A Davies
BACKGROUND: Obesity has been linked to increased mortality in several cancer types; however, the relation between obesity and survival outcomes in metastatic melanoma is unknown. The aim of this study was to examine the association between body-mass index (BMI) and progression-free survival or overall survival in patients with metastatic melanoma who received targeted therapy, immunotherapy, or chemotherapy. METHODS: This retrospective study analysed independent cohorts of patients with metastatic melanoma assigned to treatment with targeted therapy, immunotherapy, or chemotherapy in randomised clinical trials and one retrospective study of patients treated with immunotherapy...
February 12, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29448548/nano-sized-fume-biogas-production-from-food-waster-using-semi-continuous-anaerobic-digester
#14
Keum-Joo Park, Seong-Gyu Seo, Eun-Sik Kim, M N Islam, Hyung-Woon Song, Hyung-Sun Yoon
In this study, the nano-sized fume biogas production from food waste was investigated using lab scale semi-continuous stirred tank reactor (SCSTR) at 35 °C with 30d HRT and 30L working volume. The mesophilic digestion test was performed with three different feed materials (food waste) and food to microorganism (F/M) ratios (0.13, 0.34, and 0.27) in the same experiment. The results showed that the F/M ratios significantly affected the biogas production rate. The highest production rate was obtained at F/M ratio of 0...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448048/scholarly-activity-training-during-residency-are-we-hitting-the-mark-a-national-assessment-of-pediatric-residents
#15
Erika L Abramson, Monique M Naifeh, Michelle D Stevenson, Elizabeth Mauer, Hoda T Hammad, Linda M Gerber, Su-Ting T Li
OBJECTIVE: Participation in scholarly activity (SA) is an ACGME requirement. Yet, the authors' previous research with program directors (PDs) suggests pediatric SA training is variable and suboptimal. To help programs better meet requirements, our objective was to understand the resident perspective regarding SA training, including factors associated with satisfaction and productivity. METHODS: The authors conducted cross-sectional surveys of second and third year pediatric residents and PDs at 22 diverse programs in 2016...
February 12, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29447790/fine-particulate-matter-and-incident-coronary-heart-disease-in-the-regards-cohort
#16
Matthew Shane Loop, Leslie A McClure, Emily B Levitan, Mohammad Z Al-Hamdan, William L Crosson, Monika M Safford
Chronic exposure to fine particulate matter (PM 2.5 ) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of the effect of chronic exposure to PM 2.5 on risk for CHD do not generalize to more diverse samples. METHODS: Therefore, we estimated the relationship between chronic exposure to PM 2...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29446855/associations-between-enteral-nutrition-and-acute-respiratory-infection-among-patients-in-new-york-metropolitan-region-pediatric-long-term-care-facilities
#17
Marissa Burgermaster, Meghan Murray, Lisa Saiman, David S Seres, Elaine L Larson
BACKGROUND: Pediatric long-term care facilities (pLTCF) serve a complicated and resource-intensive patient population with high usage of nutrition support. However, the relationship between nutrition support and outcomes among pLTCF residents is not well understood. We described this relationship in three metropolitan New York pLTCF and a subsample of infants from one of these facilities with a feeding disorders unit. METHODS: In this prospective cohort study, we used logistic regression to assess relationships between enteral nutrition (EN), and acute respiratory infections (ARI) among residents (n = 720, 50% male, mean age = 5...
February 15, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29446481/clinical-parameters-of-ovarian-hyperstimulation-syndrome-ohss-following-different-hormonal-triggers-of-oocyte-maturation-in-ivf-treatment
#18
A Abbara, R Islam, S A Clarke, L Jeffers, G Christopoulos, A N Comninos, R Salim, S A Lavery, N L Vuong, P Humaidan, T W Kelsey, G H Trew, W S Dhillo
OBJECTIVE: Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic condition, predominantly related to the hormone used to induce oocyte maturation during IVF treatment. Kisspeptin is a hypothalamic neuropeptide that has recently been demonstrated to safely trigger final oocyte maturation during IVF treatment even in women at high risk of OHSS. However to date, the safety of kisspeptin has not been compared to current hormonal triggers of oocyte maturation. DESIGN: We conducted a retrospective single-centre cohort study investigating symptoms and clinical parameters of early OHSS in women at high risk of OHSS (antral follicle count or total number of follicles on day of trigger ≥23) triggered with hCG (n=40), GnRH agonist (GnRHa; n=99), or kisspeptin (n=122) at Hammersmith Hospital IVF unit, London, UK (2013-2016)...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29446332/general-medical-mental-health-and-demographic-risk-factors-associated-with-suicide-by-firearm-compared-with-other-means
#19
Jennifer M Boggs, Arne Beck, Sam Hubley, Edward L Peterson, Yong Hu, L Keoki Williams, Deepak Prabhakar, Rebecca C Rossom, Frances L Lynch, Christine Y Lu, Beth E Waitzfelder, Ashli A Owen-Smith, Gregory E Simon, Brian K Ahmedani
OBJECTIVE: Mitigation of suicide risk by reducing access to lethal means, such as firearms and potentially lethal medications, is a highly recommended practice. To better understand groups of patients at risk of suicide in medical settings, the authors compared demographic and clinical risk factors between patients who died by suicide by using firearms or other means with matched patients who did not die by suicide (control group). METHODS: In a case-control study in 2016 from eight health care systems within the Mental Health Research Network, 2,674 suicide cases from 2010-2013 were matched to a control group (N=267,400)...
February 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29446092/association-of-salivary-lactate-dehydrogenase-level-with-systemic-inflammation-in-a-japanese-population
#20
N Miyoshi, T Tanigawa, S Nishioka, K Maruyama, E Eguchi, K Tanaka, I Saito, K Yamazaki, Y Miyake
BACKGROUND AND OBJECTIVE: Salivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross-sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C-reactive protein (hs-CRP) levels in a community-based middle-aged and elderly population in Japan...
February 15, 2018: Journal of Periodontal Research
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