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https://www.readbyqxmd.com/read/28335269/galactosylated-liposomes-for-targeted-co-delivery-of-doxorubicin-vimentin-sirna-to-hepatocellular-carcinoma
#1
Hea Ry Oh, Hyun-Young Jo, James S Park, Dong-Eun Kim, Je-Yoel Cho, Pyung-Hwan Kim, Keun-Sik Kim
The combination of therapeutic nucleic acids and chemotherapeutic drugs has shown great promise for cancer therapy. In this study, asialoglycoprotein receptors (ASGPR) targeting-ligand-based liposomes were tested to determine whether they can co-deliver vimentin siRNA and doxorubicin to hepatocellular carcinoma (HCC) selectively. To achieve this goal, we developed an ASGPR receptor targeted co-delivery system called gal-doxorubicin/vimentin siRNA liposome (Gal-DOX/siRNA-L). The Gal-DOX/siRNA-L was created via electrostatic interaction of galactose linked-cationic liposomal doxorubicin (Gal-DOX-L) on vimentin siRNA...
July 30, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335021/mri-visible-perivascular-space-location-is-associated-with-alzheimer-s-disease-independently-of-amyloid-burden
#2
Gargi Banerjee, Hee Jin Kim, Zoe Fox, H Rolf Jäger, Duncan Wilson, Andreas Charidimou, Han Kyu Na, Duk L Na, Sang Won Seo, David J Werring
Perivascular spaces that are visible on magnetic resonance imaging (MRI) are a neuroimaging marker of cerebral small vessel disease. Their location may relate to the type of underlying small vessel pathology: those in the white matter centrum semi-ovale have been associated with cerebral amyloid angiopathy, while those in the basal ganglia have been associated with deep perforating artery arteriolosclerosis. As cerebral amyloid angiopathy is an almost invariable pathological finding in Alzheimer's disease, we hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be associated with a clinical diagnosis of Alzheimer's disease, whereas those in the basal ganglia would be associated with subcortical vascular cognitive impairment...
February 17, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334536/diode-characteristics-approaching-bulk-limits-in-gaas-nanowire-array-photodetectors
#3
Alan Cervantes Farrell, Pradeep Nuwan Senanayake, Xiao Meng, Nick Y Hsieh, Diana L Huffaker
We present the electrical properties of p-n junction photodetectors comprised of vertically oriented p-GaAs nanowire arrays on n-GaAs substrate. We measure an ideality factor as low as n = 1.0 and a rectification ratio > 10(8) across all devices, with some > 10(9), comparable to the best GaAs thin film photodetectors. Analysis of the Arrhenius plot of the saturation current yields an activation energy of 690 meV - approximately half the bandgap of GaAs - indicating generation-recombination current from mid-gap states is the primary contributor to the leakage current at low bias...
March 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28334410/pretty-picky-for-a-generalist-impacts-of-toxicity-and-nutritional-quality-on-mantid-prey-processing
#4
Jamie L Rafter, Justin F Vendettuoli, Liahna Gonda-King, Daniel Niesen, Navindra P Seeram, Chad M Rigsby, Evan L Preisser
Prey have evolved a number of defenses against predation, and predators have developed means of countering these protective measures. Although caterpillars of the monarch butterfly, Danaus plexippus L., are defended by cardenolides sequestered from their host plants, the Chinese mantid Tenodera sinensis Saussure guts the caterpillar before consuming the rest of the body. We hypothesized that this gutting behavior might be driven by the heterogeneous quality of prey tissue with respect to toxicity and/or nutrients...
March 20, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28334294/an-examination-of-the-role-of-l-glutamate-and-inosine-5-monophosphate-in-hedonic-taste-guided-behavior-by-mice-lacking-the-t1r1-t1r3-receptor
#5
Ginger D Blonde, Alan C Spector
The heterodimeric T1R1 + T1R3 receptor is considered critical for normal signaling of L-glutamate and 5'-ribonucleotides in the oral cavity. However, some taste-guided responsiveness remains in mice lacking one subunit of the receptor, suggesting that other receptors are sufficient to support some behaviors. Here, mice lacking both receptor subunits (KO) and wild-type (WT, both n = 13) mice were tested in a battery of behavioral tests. Mice were trained and tested in gustometers with a concentration series of Maltrin-580, a maltodextrin, in a brief-access test (10-s trials) as a positive control...
March 17, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28334245/coordinated-nitrogen-and-carbon-remobilization-for-nitrate-assimilation-in-leaf-sheath-and-root-and-associated-cytokinin-signals-during-early-regrowth-of-lolium-perenne
#6
Jessica Roche, Matthew H Turnbull, Qianqian Guo, Ondrej Novák, Jana Späth, Steven P Gieseg, Paula E Jameson, Jonathan Love
Background and Aims: The efficiency of N assimilation in response to defoliation is a critical component of plant regrowth and forage production. The aim of this research was to test the effect of the internal C/N balance on NO3- assimilation and to estimate the associated cytokinin signals following defoliation of perennial ryegrass ( Lolium perenne L. 'Grasslands Nui') plants. Methods: Plants, manipulated to have contrasting internal N content and contrasting availability of water soluble carbohydrates (WSCs), were obtained by exposure to either continuous light or short days (8:16 h light-dark), and watered with modified N-free Hoagland medium containing either high (5 m m ) or low (50 μ m ) NO3- as sole N source...
March 14, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28333879/intravitreal-aflibercept-injection-for-choroidal-neovascularization-due-to-presumed-ocular-histoplasmosis-syndrome-the-handle-study
#7
Brian W Toussaint, John W Kitchens, Dennis M Marcus, Daniel M Miller, Megan L Kingdon, Diana Holcomb, Ken Ivey
PURPOSE: To evaluate intravitreal aflibercept injection (IAI) in patients with presumed ocular histoplasmosis syndrome and choroidal neovascularization. METHODS: Open-label randomized Phase I/II study of IAI in patients with presumed ocular histoplasmosis syndrome-related choroidal neovascularization. Thirty-nine eyes from 39 patients were randomized in a 1:1 ratio to 2 groups. The Sustained Group eyes (n = 19) underwent monthly IAI for 3 months, then mandatory IAI every 2 months for 12 months (with an option for monthly PRN dosing, if needed)...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28333827/levels-of-silicon-in-maternal-cord-and-newborn-serum-and-their-relation-with-those-of-zinc-and-copper
#8
N Marta Díaz-Gómez, Emmanuel Bissé, Thibault Senterre, Nieves L González-González, Eduardo Domenech, Gabriele Lindinger, Thomas Epting, Flora Barroso
BACKGROUND: Evidence of silicon's importance to health has been gradually accumulating. Nevertheless, there are few studies comparing serum silicon levels in newborns with maternal levels. Likewise, little is known concerning the inter-relation between silicon and other trace elements. OBJECTIVE: The present study evaluated maternal and newborn levels of serum silicon and their relation to those of zinc and copper. METHODS: We measured serum silicon, copper, and zinc in 66 pregnant women, in the umbilical cord of their infants, and in 44 newborns, by atomic absorption spectrophotometry...
April 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28333332/wck-5222-cefepime-zidebactam-antimicrobial-activity-tested-against-gram-negative-organisms-producing-clinically-relevant-%C3%AE-lactamases
#9
Helio S Sader, Paul R Rhomberg, Robert K Flamm, Ronald N Jones, Mariana Castanheira
Background: Zidebactam is a β-lactam enhancer antibiotic with a dual mechanism of action involving binding to Gram-negative PBP2 and β-lactamase inhibition. Cefepime combined with zidebactam (WCK 5222) is under clinical development for treatment of Gram-negative infections. Objectives: To evaluate the in vitro activities of cefepime and zidebactam separately and combined at 1:1 and 2:1 ratios when tested against Gram-negative organisms producing the most clinically relevant β-lactamase types...
March 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333013/the-risk-of-radiation-induced-tumors-or-malignant-transformation-after-single-fraction-intracranial-radiosurgery-results-based-on-a-25-year-experience
#10
Bruce E Pollock, Michael J Link, Scott L Stafford, Ian F Parney, Yolanda I Garces, Robert L Foote
PURPOSE: To determine the risk of radiation-induced tumors or malignant transformation after single-fraction intracranial stereotactic radiosurgery (SRS). METHODS AND MATERIALS: We performed a retrospective review of 1837 patients who received single-fraction SRS for arteriovenous malformation or benign tumor (meningioma, vestibular schwannoma, pituitary adenoma, glomus tumor) at a single center between 1990 and 2009. Patients were excluded if they refused research authorization (n=31), had a genetic predisposition to tumor development (n=84), received prior or concurrent radiation therapy (n=79), or had less than 5 years of imaging follow-up after SRS (n=501)...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332956/high-urinary-aspartate-aminotransferase-in-the-late-posttransplant-period-predicts-rapid-progressive-decline-in-kidney-allograft-function
#11
Andriy V Trailin, Marina V Pleten, Tatiana I Ostapenko, Nadia F Iefimenko, Olexander S Nikonenko
OBJECTIVES: Scant information is available on factors for predicting the rate of decline in kidney allograft function beyond 1 year posttransplant.We investigated whether urinary enzymes (alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, N-acetyl-β-D-hexosaminidase, and ε-glutamyl transpeptidase) in the late postoperative period can predict the decline in estimated glomerular filtration rate. MATERIALS AND METHODS: In 79 kidney allograft recipients 1 to 17 years after kidney transplant, we assessed a value of urinary enzymes single measurement for predicting the slope of estimated glomerular filtration rate, rapid decline in estimated glomerular filtration rate (> 5 mL/min/1...
March 22, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28332220/perspectives-on-risk-assessment-of-risk-profiles-and-outcomes-among-women-planning-community-birth-in-the-united-states
#12
Marit L Bovbjerg, Melissa Cheyney, Jennifer Brown, Kim J Cox, Lawrence Leeman
BACKGROUND: There is little agreement on who is a good candidate for community (home or birth center) birth in the United States. METHODS: Data on n=47 394 midwife-attended, planned community births come from the Midwives Alliance of North America Statistics Project. Logistic regression quantified the independent contribution of 10 risk factors to maternal and neonatal outcomes. Risk factors included: primiparity, advanced maternal age, obesity, gestational diabetes, preeclampsia, postterm pregnancy, twins, breech presentation, history of cesarean and vaginal birth, and history of cesarean without history of vaginal birth...
March 22, 2017: Birth
https://www.readbyqxmd.com/read/28332204/evaluation-of-hmw-gs-20-and-2-2-from-near-isogenic-lines-nils-of-wheat-variety-hd2329-for-bread-quality-improvement
#13
Sonia Goel, Sapna Grewal, N K Singh
BACKGROUND: Hexaploid wheat (Triticum aestivum L.) dominates the list of the most important human food sources ever. Its complex genetic background is the reason behind the wide diversity that exists in nutritional as well as food end- product quality. High molecular weight glutenin subunits (HMW-GS) are the main grain storage proteins in the endosperm of wheat and related species. It is well established that the composition and quantity of allelic variation in (HMW-GS) genes substantially affect the taste and appearance of dough products and therefore work in this area is highly desired...
March 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28332081/modeling-of-the-morphological-change-of-cellulose-microfibrils-caused-with-aqueous-naoh-solution-the-longitudinal-contraction-and-laterally-swelling-during-decrystallization
#14
Takato Nakano
The conformation of cellulose microfibrils treated with aqueous NaOH was modeled as partially decrystallized cellulose chains before completing conversion to cellulose II, in order to elucidate the change in morphology of ramie fiber caused by NaOH treatment. Equations for the relative length and width of the microfibrils were derived on the basis of partially decrystallized microfibrils modeling. Each equation contains four parameters, n, β, w c , and c r , which correspond to the number of glucose residues between periodic defects along the untreated ramie cellulose microfibrils, the extension ratio of amorphous cellulose chain along length, the cross-section crystallinity, and the correction term of crystallinity, respectively...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28330958/intracranial-atherosclerosis-and-dementia-the-atherosclerosis-risk-in-communities-aric-study
#15
Jennifer L Dearborn, Yiyi Zhang, Ye Qiao, Muhammad Fareed K Suri, Li Liu, Rebecca F Gottesman, Andreea M Rawlings, Thomas H Mosley, Alvaro Alonso, David S Knopman, Eliseo Guallar, Bruce A Wasserman
OBJECTIVE: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. METHODS: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the population-based Atherosclerosis Risk in Communities Study by a sampling strategy that allowed weighting back to the cohort. We defined ICAD by plaque features (presence, territory, stenosis, number). Trained clinicians used an algorithm incorporating information from interviews and neuropsychological and neurologic examinations to adjudicate for MCI and dementia...
March 22, 2017: Neurology
https://www.readbyqxmd.com/read/28330260/impact-of-forest-vegetation-on-soil-characteristics-a-correlation-between-soil-biological-and-physico-chemical-properties
#16
L R Chandra, S Gupta, V Pande, N Singh
Temperate and dry deciduous forest covers major portion of terrestrial ecosystem in India. The two forest types with different dominant tree species differ in litter quality and root exudates, thereby exerting species-specific impact on soil properties and microbial activity. This study aims to examine the influence of forest type or dominant tree species on soil physico-chemical properties and its relationship with microbial characters in temperate and dry deciduous forest types. We assessed soil physico-chemical properties among five different sites located within the selected forest stand covered by different dominant species...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329948/-evaluation-of-estimation-of-prevalence-ratio-using-bayesian-log-binomial-regression-model
#17
W L Gao, H Lin, X N Liu, X W Ren, J S Li, X P Shen, S L Zhu
To evaluate the estimation of prevalence ratio (PR) by using bayesian log-binomial regression model and its application, we estimated the PR of medical care-seeking prevalence to caregivers' recognition of risk signs of diarrhea in their infants by using bayesian log-binomial regression model in Openbugs software. The results showed that caregivers' recognition of infant' s risk signs of diarrhea was associated significantly with a 13% increase of medical care-seeking. Meanwhile, we compared the differences in PR's point estimation and its interval estimation of medical care-seeking prevalence to caregivers' recognition of risk signs of diarrhea and convergence of three models (model 1: not adjusting for the covariates; model 2: adjusting for duration of caregivers' education, model 3: adjusting for distance between village and township and child month-age based on model 2) between bayesian log-binomial regression model and conventional log-binomial regression model...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28329797/social-connectedness-perceived-isolation-and-dementia-does-the-social-environment-moderate-the-relationship-between-genetic-risk-and-cognitive-well-being
#18
Judith L Poey, Jeffrey A Burr, J Scott Roberts
Purpose of the Study: This study examined whether the social environment moderates the relationship between the APOE e4 allele and cognitive functioning. Design and Methods: The Aging, Demographics, and Memory Study (ADAMS) data and multinomial logistic regression models were used to investigate these relationships for a nationally representative sample of U.S. adults aged 70 and older (n = 779). Results: Living alone (relative risk ratio [RRR] = 5...
January 24, 2017: Gerontologist
https://www.readbyqxmd.com/read/28329464/left-ventricular-retraining-and-double-switch-in-patients-with-congenitally-corrected-transposition-of-the-great-arteries
#19
Ali N Ibrahimiye, Richard D Mainwaring, William L Patrick, Laura Downey, Vamsi Yarlagadda, Frank L Hanley
PURPOSE: Congenitally corrected transposition of the great arteries (CC-TGA) is a complex form of congenital heart defect with numerous anatomic subgroups. The majority of patients with CC-TGA are excellent candidates for a double-switch procedure. However, in the absence of an unrestrictive ventricular septal defect or subpulmonary stenosis, the left ventricle (LV) may undergo involution and require retraining prior to double switch. The purpose of this study was to review our experience with patients having CC-TGA who required LV retraining prior to a double-switch procedure...
March 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28329356/sleep-disturbances-and-risk-of-hospitalization-and-inpatient-days-among-older-women
#20
Misti L Paudel, Brent C Taylor, Tien N Vo, Allyson M Kats, John T Schousboe, Li-Yung Lui, Charles E McCulloch, Lisa Langsetmo, Sonia Ancoli-Israel, Susan Redline, Kristine Yaffe, Katie L Stone, Teresa A Hillier, Kristine E Ensrud
Study Objective: Determine the associations of sleep disturbances with hospitalization risk among older women. Methods: 1,827 women (mean age 83.6 years) participating in Study of Osteoporotic Fractures Year 16 (Y16) examination (2002-2004) linked with Medicare and/or HMO claims. At Y16 examination, sleep/wake parameters were measured by actigraphy (total sleep time [TST], sleep efficiency [SE], sleep latency [SL], and wake after sleep onset [WASO]) and subjective sleep measures (sleep quality [Pittsburgh Sleep Quality Index] and daytime sleepiness [Epworth Sleepiness Scale]) were assessed by questionnaire...
March 1, 2017: Sleep
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