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https://www.readbyqxmd.com/read/28454353/prmt8-demonstrates-variant-specific-expression-in-cancer-cells-and-correlates-with-patient-survival-in-breast-ovarian-and-gastric-cancer
#1
Sarah J Hernandez, David M Dolivo, Tanja Dominko
Recent emphasis has been placed on the role of epigenetic regulators and epigenetic marks as biomarkers for cancer diagnosis and prognosis, and as therapeutic targets for treatment. One such class of regulators is the protein arginine methyltransferase (PRMT) family. The present study examined available curated data regarding the expression and alteration of one of the least studied PRMT family members, PRMT8, in various types of cancer and cancer cell lines. Publicly available cancer data on PRMT8 expression were examined using the Human Protein Atlas and the Kaplan-Meier Plotter, and reverse transcription-polymerase chain reaction was used to screen a selection of human cell lines for variant-specific PRMT8 expression...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454327/stereotactic-radiotherapy-in-the-treatment-of-local-recurrences-of-esophageal-cancer
#2
Marcel Matzenauer, David Vrána, Zuzana Vlachová, Rene Aujesky, Radek Vrba, Cestmir Neoral, Bohuslav Melichar
Esophageal cancer (EC) consists of tumors with a generally poor prognosis, and treatment options for patients with disease recurrence are extremely limited. Due to this poor patient prognosis, the possible treatment toxicity should be carefully balanced against its potential benefit and patient quality of life. Stereotactic body radiotherapy (SBRT) is a rapidly expanding novel technique combining a short treatment time together with high local efficacy and an acceptable toxicity profile. There are no publications thus far presenting data regarding the usage of SBRT utilizing a conventional linear accelerator in locally recurrent EC patients...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454105/tea-consumption-and-the-risk-of-biliary-tract-cancer-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#3
Jianping Xiong, Jianzhen Lin, Anqiang Wang, Yaqin Wang, Ying Zheng, Xinting Sang, Yiyao Xu, Xin Lu, Haitao Zhao
Recent studies have shown that tea consumption is associated with the reduced incidence of some types of cancer, possibly including biliary tract cancer. However, the epidemiological evidences for the association with risk of biliary tract cancer are contradictory. Thus, we performed meta-analysis of published observational studies to assess the association between tea consumption and risk of biliary tract cancer. Relevant studies were identified by searching PubMed, EMBASE, and ISI Web of Science published before October 2016...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454104/rna-sequencing-based-cell-proliferation-analysis-across-19-cancers-identifies-a-subset-of-proliferation-informative-cancers-with-a-common-survival-signature
#4
Ryne C Ramaker, Brittany N Lasseigne, Andrew A Hardigan, Laura Palacio, David S Gunther, Richard M Myers, Sara J Cooper
Despite advances in cancer diagnosis and treatment strategies, robust prognostic signatures remain elusive in most cancers. Cell proliferation has long been recognized as a prognostic marker in cancer, but the generation of comprehensive, publicly available datasets allows examination of the links between cell proliferation and cancer characteristics such as mutation rate, stage, and patient outcomes. Here we explore the role of cell proliferation across 19 cancers (n = 6,581 patients) by using tissue-based RNA sequencing data from The Cancer Genome Atlas Project and calculating a 'proliferative index' derived from gene expression associated with Proliferating Cell Nuclear Antigen (PCNA) levels...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454102/an-inverse-association-between-tea-consumption-and-colorectal-cancer-risk
#5
Yuetong Chen, Yuan Wu, Mulong Du, Haiyan Chu, Lingjun Zhu, Na Tong, Zhengdong Zhang, Meilin Wang, Dongying Gu, Jinfei Chen
It is well known that the tea extracts, mainly polyphenols as chemo-preventive elements, could act as cancer progression blockers. Although the association between tea consumption and colorectal cancer risk has been widely investigated, the results still remain inconsistent. We conducted a dose-response meta-analysis to evaluate their relationships by enrolling qualified 29 literatures. The summary odds ratio (OR) of colorectal cancer for the highest vs. lowest tea consumption was 0.93 with 0.87-1.00 of 95% confidence intervals (CIs) among all studies with modest heterogeneity (P = 0...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454068/biochar-based-water-treatment-systems-as-a-potential-low-cost-and-sustainable-technology-for-clean-water-provision
#6
REVIEW
Willis Gwenzi, Nhamo Chaukura, Chicgoua Noubactep, Fungai N D Mukome
Approximately 600 million people lack access to safe drinking water, hence achieving Sustainable Development Goal 6 (Ensure availability and sustainable management of water and sanitation for all by 2030) calls for rapid translation of recent research into practical and frugal solutions within the remaining 13 years. Biochars, with excellent capacity to remove several contaminants from aqueous solutions, constitute an untapped technology for drinking water treatment. Biochar water treatment has several potential merits compared to existing low-cost methods (i...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28454067/assessment-of-the-swat-model-to-simulate-a-watershed-with-limited-available-data-in-the-pampas-region-argentina
#7
Martín Romagnoli, Margarita Portapila, Alfredo Rigalli, Gisela Maydana, Martín Burgués, Carlos M García
Argentina has been among the world leaders in the production and export of agricultural products since the 1990s. The Carcarañá River Lower Basin (CRLB), a cropland of the Pampas region supplied by extensive rainfall, is located in an area with few streamgauging and other hydrologic/water-quality stations. Therefore, limited hydrologic data are available resulting in limited water-resources assessment. This work explores the application of Soil and Water Assessment Tool (SWAT) model to the CRLB in the Santa Fe province of the Pampas region...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454045/canadian-harm-reduction-policies-a-comparative-content-analysis-of-provincial-and-territorial-documents-2000-2015
#8
REVIEW
T Cameron Wild, Bernie Pauly, Lynne Belle-Isle, Walter Cavalieri, Richard Elliott, Carol Strike, Kenneth Tupper, Andrew Hathaway, Colleen Dell, Donald MacPherson, Caitlin Sinclair, Kamagaju Karekezi, Benjamin Tan, Elaine Hyshka
BACKGROUND: Access to harm reduction interventions among substance users across Canada is highly variable, and largely within the policy jurisdiction of the provinces and territories. This study systematically described variation in policy frameworks guiding harm reduction services among Canadian provinces and territories as part of the first national multimethod case study of harm reduction policy. METHODS: Systematic and purposive searches identified publicly-accessible policy texts guiding planning and organization of one or more of seven targeted harm reduction services: needle distribution, naloxone, supervised injection/consumption, low-threshold opioid substitution (or maintenance) treatment, buprenorphine/naloxone (suboxone), drug checking, and safer inhalation kits...
April 25, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28454035/occurrence-and-genetic-diversity-of-cryptosporidium-and-giardia-in-urban-wastewater-treatment-plants-in-north-eastern-spain
#9
Ana Ramo, Emilio Del Cacho, Caridad Sánchez-Acedo, Joaquín Quílez
This study was designed to investigate the presence and removal efficiency of Cryptosporidium and Giardia in wastewater treatment plants at the 20 most populated towns in Aragón (north-eastern Spain). Samples of influent and effluent wastewater and dewatered sewage sludge were collected seasonally from 23 plants and processed according to USEPA Method 1623. All samples from raw and treated wastewater tested positive for Giardia, at an average concentration of 3247±2039cysts/l and 50±28cysts/l, respectively...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454015/air-pollution-characteristics-and-health-risks-in-henan-province-china
#10
Fuzhen Shen, Xinlei Ge, Jianlin Hu, Dongyang Nie, Li Tian, Mindong Chen
Events of severe air pollution occurred frequently in China recently, thus understanding of the air pollution characteristics and its health risks is very important. In this work, we analyzed a two-year dataset (March 2014 - February 2016) including daily concentrations of six criteria pollutants (PM2.5, PM10, CO, SO2, NO2, and O3) from 18 cities in Henan province. Results reveal the serious air pollution status in Henan province, especially the northern part, and Zhengzhou is the city with the worst air quality...
April 25, 2017: Environmental Research
https://www.readbyqxmd.com/read/28454014/reduced-mouse-allergen-is-associated-with-epigenetic-changes-in-regulatory-genes-but-not-mouse-sensitization-in-asthmatic-children
#11
Rachel L Miller, Hanjie Zhang, Jacqueline Jezioro, Mariangels De Planell Saguer, Stephanie Lovinsky-Desir, Xinhua Liu, Matthew Perzanowski, Adnan Divjan, Wanda Phipatanakul, Elizabeth C Matsui
Chronic exposure to mouse allergen may contribute greatly to the inner-city asthma burden. We hypothesized that reducing mouse allergen exposure may modulate the immunopathology underlying symptomatic pediatric allergic asthma, and that this occurs through epigenetic regulation. To test this hypothesis, we studied a cohort of mouse sensitized, persistent asthmatic inner-city children undergoing mouse allergen-targeted integrated pest management (IPM) vs education in a randomized controlled intervention trial...
April 25, 2017: Environmental Research
https://www.readbyqxmd.com/read/28454007/groundwater-remediation-from-the-past-to-the-future-a-bibliometric-analysis
#12
Shu Zhang, Guozhu Mao, John Crittenden, Xi Liu, Huibin Du
Groundwater is an important component of terrestrial ecosystems and plays a role in geochemical cycling. Groundwater is also used for agricultural irrigation and for the domestic supply of drinking water in most nations. However, groundwater contamination has led to many research efforts on groundwater remediation technologies and strategies. This study evaluated a total of 5486 groundwater remediation-related publications from 1995 to 2015 using bibliometric technology and social network analysis, to provide a quantitative analysis and a global view on the current research trend and future research directions...
January 19, 2017: Water Research
https://www.readbyqxmd.com/read/28453991/advocacy-coalitions-and-protected-areas-creation-process-case-study-in-the-amazon
#13
Sandra Nicolle, Maya Leroy
Protected areas are the cornerstones of conservation policies worldwide. However, only few researches are led to analyse the way they emerge, except for criticising top-down governmental choices. Yet, the historical approach and strategic analysis of public policy building over the long term allows a better understanding of the stakes of action capacity of these policies. We therefore mobilize the advocacy coalition framework to show that protected areas creation is always due to coalitions of actors who belong to different professional fields and act at different scales but nevertheless share common stakes...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28453915/documenting-and-harnessing-the-biological-potential-of-molecules-in-distributed-drug-discovery-d3-virtual-catalogs
#14
Milata M Abraham, Ryan E Denton, Richard W Harper, William L Scott, Martin J O'Donnell, Jacob D Durrant
Virtual molecular catalogs have limited utility if member compounds are (1) difficult to synthesize or (2) unlikely to have biological activity. The Distributed Drug Discovery (D3) program addresses the synthesis challenge by providing scientists with a free virtual D3 catalog of 73,024 easy-to-synthesize N-acyl unnatural α-amino acids, their methyl esters, and primary amides. The remaining challenge is to document and exploit the bioactivity potential of these compounds. In the current work, a search process is described that retrospectively identifies all virtual D3 compounds classified as bioactive hits in PubChem-cataloged experimental assays...
April 28, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28453886/remote-diagnosis-of-traumatic-dental-injuries-using-digital-photographs-captured-via-a-mobile-phone
#15
Rogério de Almeida Geraldino, Liliana Vicente Melo de Lucas Rezende, Cibele Queiroz da-Silva, Júlio César Franco Almeida
BACKGROUND: Intra-oral photographs has been aided diagnosis of several pathologies in teledentistry. Mobile phone cameras may produce high quality photographs, presenting itself as a viable tool for remote diagnosis of traumatic dental injuries. Aim To evaluate the levels of inter-examiner agreement in cases of traumatic dental injuries when comparing diagnoses conducted in person and remotely. MATERIAL AND METHODS: The sample included 40 patients with 73 traumatized teeth, and a total of 90 diagnoses, who had presented to two dental clinics, one private and the other public, in Brazil's Federal District...
April 28, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28453863/use-of-a-geographic-information-system-to-assess-accessibility-to-health-facilities-providing-emergency-obstetric-and-newborn-care-in-bangladesh
#16
Mahbub E Chowdhury, Taposh K Biswas, Monjur Rahman, Kamal Pasha, Mollah A Hossain
OBJECTIVE: To use a geographic information system (GIS) to determine accessibility to health facilities for emergency obstetric and newborn care (EmONC) and compare coverage with that stipulated by UN guidelines (5 EmONC facilities per 500 000 individuals, ≥1 comprehensive). METHODS: A cross-sectional study was undertaken of all public facilities providing EmONC in 24 districts of Bangladesh from March to October 2012. Accessibility to each facility was assessed by applying GIS to estimate the proportion of catchment population (comprehensive 500 000; basic 100 000) able to reach the nearest facility within 2 hours and 1 hour of travel time, respectively, by existing road networks...
April 28, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28453809/in-patients-undergoing-lung-resection-is-it-safe-to-administer-amiodarone-either-as-prophylaxis-or-treatment-of-atrial-fibrillation
#17
Styliani Maria Kolokotroni, Levon Toufektzian, Leanne Harling, Andrea Billè
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether the administration of amiodarone is safe in patients undergoing lung resection either for prophylaxis or treatment of de novo postoperative atrial fibrillation (POAF). A total of 30 papers were identified, of which 13 represented the best evidence to answer the clinical question. The authors, journal, date, study type, country of publication, patient demographics, relevant outcomes and results were tabulated...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453803/does-cervical-lymph-node-recurrence-after-oesophagectomy-or-definitive-chemoradiotherapy-for-thoracic-oesophageal-squamous-cell-carcinoma-benefit-from-salvage-treatment
#18
Xiaoli Yuan, Jiahua Lv, Hang Dong, Jiuhui Wang
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment?' Altogether, 659 articles were found using the reported search, of which 8 represented the best evidence to answer the clinical question. The authors, journal, date, country of publication, patient group studied, study type, relevant outcomes and results of these articles were tabulated...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453801/does-perioperative-chemotherapy-improve-survival-in-patients-with-resectable-lung-metastases-of-colorectal-cancer
#19
Francesco Guerrera, Pierre-Emmanuel Falcoz, Stephane Renaud, Gilbert Massard
A best evidence topic was constructed according to a structured protocol. The question addressed was whether the administration of perioperative chemotherapy (CT) is effective in improving survival in patients with resectable lung metastases of colorectal cancer (CRC). Of the 44 papers found using a report search, 6 investigated the effect of perioperative CT (adjuvant-CT, preoperative-CT or both) on outcomes in patients undergoing lung metastasectomy for CRC. These 6 studies presented the best evidence to answer the clinical question...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453720/-seeking-affluent-neighbourhoods-a-time-trend-analysis-of-geographical-distribution-of-hospitals-in-the-megacity-of-tehran
#20
Yousef Chavehpour, Arash Rashidian, Hossein Raghfar, Sara Emamgholipour Sefiddashti, Aiub Maroofi
Objective: Access to hospitals in megacities in low and middle income countries might be hampered by travel barriers and distance. We assessed the 'inverse care law' hypothesis: whether hospitals tended to be built in the relatively better-off areas through the time. Methods: A longitudinal time-series study (1966 to 2011) in Tehran to measure inequality in the distribution of hospital beds. We assessed correlations between the district socioeconomic status and availability of hospital beds via regression analyses, estimated correlation, Gini and concentration indices, and used GIS models to map hospital distributions through time...
June 1, 2017: Health Policy and Planning
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