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Radiation fibrosis

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https://www.readbyqxmd.com/read/28437189/metformin-attenuates-radiation-induced-pulmonary-fibrosis-in-a-murine-model
#1
Jian Wang, Ye Wang, Jun Han, Hong Mei, Dandan Yu, Qian Ding, Tao Zhang, Gang Wu, Gang Peng, Zhenyu Lin
While radiotherapy continues to be a major cancer treatment option, its dose-limiting side effects, such as pulmonary fibrosis, severely impair the quality of life in these patients. In this study, we evaluated the radioprotective effects of metformin, a commonly used biguanide antidiabetic medication, in a murine model of pulmonary damage. Sprague Dawley(®) rats received whole lung 20 Gy irradiation with or without metformin treatment. Computed tomography (CT) was performed and Hounsfield units (HU) were determined during the observation period...
April 24, 2017: Radiation Research
https://www.readbyqxmd.com/read/28436606/early-and-late-adverse-effects-of-radioiodine-for-pediatric-differentiated-thyroid-cancer
#2
Domenico Albano, Francesco Bertagna, Maria Beatrice Panarotto, Raffaele Giubbini
BACKGROUND: Radioiodine-131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults but less analyzed in children. Our aim was to describe early and late adverse events of radioactive I131 in pediatric patients. METHODS: All consecutive patients ≤18 years treated for DTC in the period 1980-2015 were retrospectively analyzed for early and late side effects of radioiodine...
April 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28421350/preoperative-imaging-evaluation-of-pancreatic-pathologies-for-the-objective-prediction-of-pancreatic-fistula-after-pancreaticoduodenectomy
#3
REVIEW
Yoshitsugu Tajima, Yasunari Kawabata, Noriyuki Hirahara
In performing pancreaticoduodenectomy (PD) or when conducting clinical trials involving PD procedure, a universal platform for predicting the risk of postoperative pancreatic fistula (POPF) is indispensable. In this article, the most significant imaging studies that focused on the objective preoperative assessment of pancreatic pathologies in association with the occurrence of POPF after PD were reviewed. Several recently developed imaging modalities can objectively predict the occurrence of POPF after PD by assessing the elasticity, fibrosis, and fatty infiltration of the pancreas...
April 18, 2017: Surgery Today
https://www.readbyqxmd.com/read/28415830/triptolide-mitigates-radiation-induced-pneumonitis-via-inhibition-of-alveolar-macrophages-and-related-inflammatory-molecules
#4
Chun Chen, Shanmin Yang, Mei Zhang, Zhenhuan Zhang, Steven B Zhang, Bing Wu, Jinsheng Hong, Weijian Zhang, Jianhua Lin, Paul Okunieff, Lurong Zhang
Ionizing radiation-induced pulmonary injury is a major limitation of radiotherapy for thoracic tumors. We have demonstrated that triptolide (TPL) could alleviate IR-induced pneumonia and pulmonary fibrosis. In this study, we explored the underlying mechanism by which TPL mitigates the effects of radiotoxicity. The results showed that:(1) Alveolar macrophages (AMs) were the primary inflammatory cells infiltrating irradiated lung tissues and were maintained at a high level for at least 17 days, which TPL could reduce by inhibiting of the production of macrophage inflammatory protein-2 (MIP-2) and its receptor CXCR2...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407283/acoustic-radiation-force-impulse-imaging-for-assessing-liver-fibrosis-preoperatively-in-infants-with-biliary-atresia-comparison-with-liver-fibrosis-biopsy-pathology
#5
Fen Gao, Ya-Qing Chen, Jing Fang, Sheng-Li Gu, Luan Li, Xiao-Ying Wang
OBJECTIVES: The purpose of this study was to investigate the diagnostic performance of acoustic radiation force impulse (ARFI) in assessing liver fibrosis preoperatively in infants with biliary atresia (BA). METHODS: A total of 50 consecutive infants with BA and 50 healthy infants who underwent ARFI examination were recruited. Siemens Acuson S2000 in Virtual Touch Quantification mode (Siemens Medical Solutions, Mountain View, CA) was used to measure shear wave speeds (SWSs)...
April 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28407281/multiparametric-quantitative-ultrasound-imaging-in-assessment-of-chronic-kidney-disease
#6
Jing Gao, Alan Perlman, Safa Kalache, Nathaniel Berman, Surya Seshan, Steven Salvatore, Lindsey Smith, Natasha Wehrli, Levi Waldron, Hanish Kodali, James Chevalier
OBJECTIVES: To evaluate the value of multiparametric quantitative ultrasound imaging in assessing chronic kidney disease (CKD) using kidney biopsy pathologic findings as reference standards. METHODS: We prospectively measured multiparametric quantitative ultrasound markers with grayscale, spectral Doppler, and acoustic radiation force impulse imaging in 25 patients with CKD before kidney biopsy and 10 healthy volunteers. Based on all pathologic (glomerulosclerosis, interstitial fibrosis/tubular atrophy, arteriosclerosis, and edema) scores, the patients with CKD were classified into mild (no grade 3 and <2 of grade 2) and moderate to severe (at least 2 of grade 2 or 1 of grade 3) CKD groups...
April 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28405105/hesperidin-as-radioprotector-against-radiation-induced-lung-damage-in-rat-a-histopathological-study
#7
Gholam Hassan Haddadi, Abolhasan Rezaeyan, Mohammad Amin Mosleh-Shirazi, Massood Hosseinzadeh, Reza Fardid, Masoud Najafi, Ashkan Salajegheh
Reactive oxygen species (ROS) are generated by ionizing radiation, and one of the organs commonly affected by ROS is the lung. Radiation-induced lung injury including pneumonia and lung fibrosis is a dose-limiting factor in radiotherapy (RT) of patients with thorax irradiation. Administration of antioxidants has been proved to protect against ROS. The present study was aimed to assess the protective effect of hesperidin (HES) against radiation-induced lung injury of male rats. Fifty rats were divided into three groups...
January 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28403885/lung-structure-and-function-similarities-between-primary-ciliary-dyskinesia-and-mild-cystic-fibrosis-a-pilot-study
#8
Marco Maglione, Silvia Montella, Carmine Mollica, Vincenzo Carnovale, Paola Iacotucci, Fabiola De Gregorio, Antonella Tosco, Mariarosaria Cervasio, Valeria Raia, Francesca Santamaria
BACKGROUND: Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) are increasingly compared. There are no chest magnetic resonance imaging (MRI) comparative studies of PCD and CF. We assessed clinical, functional, microbiological and MRI findings in PCD and mild CF patients in order to evaluate different expression of lung disease. METHODS: Twenty PCD (15.1 years) and 20 CF subjects with mild respiratory impairment (16 years, 70% with pancreatic insufficiency) underwent MRI, spirometry, and sputum cultures when clinically stable...
April 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28402936/lysophosphatidic-acid-lpa-as-a-pro-fibrotic-and-pro-oncogenic-factor-a-pivotal-target-to-improve-the-radiotherapy-therapeutic-index
#9
REVIEW
Chloé Rancoule, Sophie Espenel, Jane-Chloé Trone, Julien Langrand-Escure, Alexis Vallard, Amel Rehailia-Blanchard, Anis El Meddeb Hamrouni, Yaxiong Xia, Jean-Baptiste Guy, Majed Ben-Mrad, Nicolas Magné
Radiation-induced fibrosis is widely considered as a common but forsaken phenomenon that can lead to clinical sequela and possibly vital impairments. Lysophosphatidic acid is a bioactive lipid involved in fibrosis and probably in radiation-induced fibrosis as suggested in recent studies. Lysophosphatidic acid is also a well-described pro-oncogenic factor, involved in carcinogenesis processes (proliferation, survival, angiogenesis, invasion, migration). The present review highlights and summarizes the links between lysophosphatidic acid and radiation-induced fibrosis, lysophosphatidic acid and radioresistance, and proposes lysophosphatidic acid as a potential central actor of the radiotherapy therapeutic index...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28391959/does-clinical-indication-play-a-role-in-ct-radiation-dose-in-pediatric-patients
#10
Sotiria Triantopoulou, Virginia Tsapaki
PURPOSE: The purpose of this study was to identify the main pathologies for which CT is applied on pediatric patients and the related radiation doses as reported in the literature in order to facilitate justification and CT optimization. METHODS: A critical analysis of a literature review was performed. Different search engines were used such as PubMed, Google Scholar and Science Direct. Various terms and keywords were used to locate pertinent articles such as Pediatric, Computed tomography, Radiation Dose, Organ dose, Effective dose...
April 5, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28385367/-radiation-induced-bronchiolitis-obliterans-with-organizing-pneumonia
#11
J Ducray, S Vignot, A Lacout, I Pougnet, P-Y Marcy, C Chapellier, N Foray, A Creisson, J Thariat
Bronchiolitis obliterans with organizing pneumonia is an inflammatory reaction that can occur as a consequence of various pulmonary affections. Radiotherapy is not the sole and systematic cause of bronchiolitis obliterans with organizing pneumonia. Radiation-induced should not be confused with post-radiation, dose-dependent, inflammatory pulmonary fibrosis, which is non-immunological and located within the irradiation field. The role of immunity, local inflammation and individual radiosensitivity in bronchiolitis obliterans with organizing pneumonia is not well defined...
April 3, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28383564/development-of-a-simple-noninvasive-model-to-predict-significant-fibrosis-in-patients-with-chronic-hepatitis-b-combination-of-ultrasound-elastography-serum-biomarkers-and-individual-characteristics
#12
Xin Chen, Huiying Wen, Xinyu Zhang, Changfeng Dong, Haoming Lin, Yanrong Guo, Lingbo Shan, Simin Yao, Min Yang, Xiaohua Le, Yingxia Liu
OBJECTIVES: The accurate assessment of liver fibrosis is clinically important in patients with chronic hepatitis B (CHB). Blood tests and elastography are now widely used for the noninvasive diagnosis of liver fibrosis in CHB patients. The aim of this study was to develop a new and more accurate predictive model, which combines elastography data, serum biomarkers, and individual characteristics, to discriminate between CHB patients with and without significant liver fibrosis. METHODS: Two noninvasive methods, specifically, an ultrasound elastography technique termed acoustic radiation force impulse imaging (ARFI) and a blood test, were used to assess a cohort of 345 patients (estimation group, 218 patients; validation group, 127 patients) with CHB...
April 6, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28381537/type-i-collagen-targeted-pet-probe-for-pulmonary-fibrosis-detection-and-staging-in-preclinical-models
#13
Pauline Désogère, Luis F Tapias, Lida P Hariri, Nicholas J Rotile, Tyson A Rietz, Clemens K Probst, Francesco Blasi, Helen Day, Mari Mino-Kenudson, Paul Weinreb, Shelia M Violette, Bryan C Fuchs, Andrew M Tager, Michael Lanuti, Peter Caravan
Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity, environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis (IPF)]. Overexpression of collagen is a hallmark of organ fibrosis. We describe a peptide-based positron emission tomography (PET) probe ((68)Ga-CBP8) that targets collagen type I. We evaluated (68)Ga-CBP8 in vivo in the bleomycin-induced mouse model of pulmonary fibrosis. (68)Ga-CBP8 showed high specificity for pulmonary fibrosis and high target/background ratios in diseased animals...
April 5, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28378548/effect-of-coenzyme-q10-on-radiation-nephropathy-in-rats
#14
Yongkan Ki, Wontaek Kim, Yong Ho Kim, Donghyun Kim, Jin Sook Bae, Dahl Park, Hosang Jeon, Ju Hye Lee, Jayoung Lee, Jiho Nam
The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28376190/effects-of-ctgf-blockade-on-attenuation-and-reversal-of-radiation-induced-pulmonary-fibrosis
#15
Sebastian Bickelhaupt, Christian Erbel, Carmen Timke, Ute Wirkner, Monika Dadrich, Paul Flechsig, Alexandra Tietz, Johanna Pföhler, Wolfgang Gross, Peter Peschke, Line Hoeltgen, Hugo A Katus, Hermann-Josef Gröne, Nils H Nicolay, Rainer Saffrich, Jürgen Debus, Mark D Sternlicht, Todd W Seeley, Kenneth E Lipson, Peter E Huber
Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (CTGF) is a central mediator of tissue remodeling. Methods: A radiation-induced mouse model of pulmonary fibrosis was used to determine if transient administration of a human antibody to CTGF (FG-3019) started at different times before or after 20 Gy thoracic irradiation reduced acute and chronic radiation toxicity...
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28374300/the-impact-of-expander-inflation-deflation-status-during-adjuvant-radiotherapy-on-the-complications-of-immediate-two-stage-breast-reconstruction
#16
Kyong-Je Woo, Joo-Myeong Paik, Sa Ik Bang, Goo-Hyun Mun, Jai-Kyong Pyon
BACKGROUND: The question of whether expander inflation/deflation status has any bearing on surgical complications in the setting of adjuvant radiation (XRT) has not been addressed. The objective of this study is to investigate whether the inflation/deflation status of the expander at the time of XRT is associated with complications in immediate two-stage expander-implant breast reconstruction. METHODS: A retrospective review of 49 consecutive patients who underwent immediate two-stage expander-implant breast reconstruction and received post-mastectomy XRT was conducted...
April 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28357031/concordance-of-non-invasive-mechanical-and-serum-tests-for-liver-fibrosis-evaluation-in-chronic-hepatitis-c
#17
Denise C Paranaguá-Vezozzo, Adriana Andrade, Daniel F C Mazo, Vinicius Nunes, Ana L Guedes, Taisa G Ragazzo, Renata Moutinho, Lucas S Nacif, Suzane K Ono, Venâncio A F Alves, Flair J Carrilho
AIM: To determine the sensitivity and specificity of liver stiffness measurement (LSM) and serum markers (SM) for liver fibrosis evaluation in chronic hepatitis C. METHODS: Between 2012 and 2014, 81 consecutive hepatitis C virus (HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography (TE) [FibroScan(®)/ARFI technology (Virtual Touch(®))] and SM [FIB-4/aspartate aminotransferase-to-platelet ratio index (APRI)]...
March 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28356370/comorbidities-in-the-management-of-patients-with-lung-cancer
#18
Charlotte Leduc, Delphine Antoni, Anne Charloux, Pierre-Emmanuel Falcoz, Elisabeth Quoix
Lung cancer represents a major public health issue worldwide. Unfortunately, more than half of them are diagnosed at an advanced stage. Moreover, even if diagnosed early, diagnosis procedures and treatment can be difficult due to the frequent comorbidities observed in these patients. Some of these comorbidities have a common major risk factor, i.e. smoking, whereas others are unrelated to smoking but frequently observed in the general population. These comorbidities must be carefully assessed before any diagnostic and/or therapeutic decisions are made regarding the lung cancer...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28351583/candidate-apoptotic-and-dna-repair-gene-approach-confirms-involvement-of-ercc1-ercc5-tp53-and-mdm2-in-radiation-induced-toxicity-in-head-and-neck-cancer
#19
D Borchiellini, M C Etienne-Grimaldi, R J Bensadoun, K Benezery, O Dassonville, G Poissonnet, L Llorca, N Ebran, P Formento, Y Château, J Thariat, G Milano
INTRODUCTION: Single nucleotide polymorphisms (SNPs) of DNA repair and apoptosis genes have been associated with outcome in head and neck squamous cell carcinoma (HNSCC) patients receiving radiotherapy (RT). Our goal was to conduct a candidate gene study in HNSCC patients receiving RT or chemoRT. METHODS: 122 non-resectable HNSCC patients undergoing RT (N=38) or chemoRT (N=84) between 1992 and 2006 were retrospectively analyzed. ERCC1 Lys259Thr (rs735482), ERCC2 Lys751Gln (rs13181), ERCC5 His46His C>T (rs1047768), XRCC1 Arg399Gln (rs25487), TP53 Arg72Pro (rs1042522) and MDM2 309T>G (rs2279744) were analyzed on tumor DNA...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28343660/a-pilot-study-of-ultrasound-elastography-as-a-non-invasive-method-to-monitor-liver-disease-in-children-with-short-bowel-syndrome
#20
Daniel Lodwick, Molly Dienhart, Jennifer N Cooper, Bonita Fung, Joseph Lopez, Sally Smith, Patrick Warren, Jane Balint, Peter C Minneci
BACKGROUND: Our objective was to evaluate the accuracy of acoustic radiation force impulse (ARFI) elastography in determining extent of liver fibrosis in pediatric patients with short bowel syndrome (SBS). METHODS: This prospective cohort study included pediatric patients with SBS who underwent ultrasound with ARFI measurements of shear wave speed (SWS) and liver biopsy within 30days of each other between 12/2014-9/2015. The mean and median SWS were compared to the stage of fibrosis...
March 16, 2017: Journal of Pediatric Surgery
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