Bence Bátai, Laura Kiss, Luca Varga, Ákos Nagy, Jacob Househam, Ann-Marie Baker, Tamás László, Anna Udvari, Róbert Horváth, Tibor Nagy, Judit Csomor, József Szakonyi, Tamás Schneider, Trevor A Graham, Donát Alpár, Jude Fitzgibbon, Ágota Szepesi, Csaba Bödör
Primary cutaneous follicle center lymphoma (PCFCL) has an excellent prognosis using local treatment, while nodal follicular lymphoma (nFL) occasionally presenting with cutaneous spread, often requires systemic therapy. Distinction of the two diseases based on histopathology alone might be challenging. Copy number alterations (CNAs) have scarcely been explored on a genome-wide scale in PCFCL, yet they might serve as potential biomarkers during differential diagnosis and risk stratification. Low-coverage whole genome sequencing (lcWGS) is a robust, high-throughput method for genome-wide copy number profiling...
March 7, 2024: Modern Pathology