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https://www.readbyqxmd.com/read/29787922/the-association-of-panic-and-hyperventilation-with-psychogenic-non-epileptic-seizures-a-systematic-review-and-meta-analysis
#1
REVIEW
Alaric M Indranada, Saul A Mullen, Roderick Duncan, David J Berlowitz, Richard A A Kanaan
INTRODUCTION: Psychogenic Non-Epileptic Seizures (PNES) are events that appear epileptic but are instead thought to have a psychological origin. Increased rates of several psychiatric disorders have been reported in PNES, including anxiety and panic disorders. Some theories suggest panic and/or hyperventilation have aetiological roles in PNES, though these remain unproven. METHODS: We conducted a systematic review of associations of panic and hyperventilation with PNES using Ovid Medline and PubMed, and a meta-analysis where appropriate...
May 19, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29785475/cohort-study-of-psychiatric-adverse-events-following-exposure-to-levonorgestrel-containing-intrauterine-devices-in-uk-general-practice
#2
Jim Slattery, Daniel Morales, Luis Pinheiro, Xavier Kurz
INTRODUCTION: Intrauterine devices are implantable contraceptives of which some brands steadily release levonorgestrel over an extended time period. Exposure to a levonorgestrel-releasing intrauterine device has been associated with depression and, more recently, a connection to anxiety, panic attacks, sleep problems and restlessness has been suggested. This study uses data from the THIN database of UK general practice to investigate these suggestions. METHODS: A cohort study was performed to compare the incidence of psychiatric adverse events between groups of women who were new users of levonorgestrel-releasing and non-hormonal intrauterine devices...
May 21, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29760763/an-open-label-flexible-dose-adaptive-study-evaluating-the-efficacy-of-vortioxetine-in-subjects-with-panic-disorder
#3
Anish Shah, Joanne Northcutt
Background: Despite the current treatments available for panic disorder (PD), as many as one-third of patients have persistent and treatment-resistant panic attacks. Vortioxetine is an approved medicine for major depressive disorder and has been shown to have anxiolytic properties. The purpose of this study was to evaluate its efficacy and safety in an adult population with a diagnosis of PD. Methods: The study design was open label with flexible dose strategies (5, 10, or 20 mg) with a treatment period of 10 weeks...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29737230/the-nitric-oxide-donor-sin-1-produced-panic-like-behaviour-and-fear-induced-antinociception-are-modulated-by-nmda-receptors-in-the-anterior-hypothalamus
#4
Luiz Luciano Falconi-Sobrinho, Norberto Cysne Coimbra
BACKGROUND: An excitatory imbalance in the hypothalamus of rodents caused by local chemical stimulation elicits fear-related defensive reactions such as escape and freezing. In addition, these panic attack-like defensive reactions induced by hypothalamic neurons may cause antinociception. However, there is a shortage of studies showing the participation of the anterior hypothalamic nucleus in these adaptive defensive mechanisms. Nitric oxide (NO) donors have been shown to evoke fear-related defensive responses when microinjected into paralimbic and limbic structures, and this excitatory neuromodulation can recruit the glutamatergic system...
April 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29680728/respiratory-subtype-of-panic-disorder-can-serum-phosphate-levels-be-a-possible-outcome-to-group-cognitive-behavior-therapy
#5
Pedro Beria, Ana Cristina W Viana, Andressa Behenck, Elizeth Heldt, Gisele Gus Manfro, Carolina Blaya Dreher
OBJECTIVE: Panic disorder (PD) respiratory subtype (RS) was described in order to cluster patients according to their symptoms. These patients are characterized by experiencing a relatively high number of noticeable respiratory symptoms during a panic attack (PA) and a higher reactivity to CO2 . In this study, we aimed to evaluate the clinical relevance of this diagnostic category, evaluating if there are different responses to cognitive-behavioral therapy in patients with panic disorder RS as compared to those with the non-respiratory subtype (NRS), using serum phosphate as a biological marker...
April 12, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29678310/grossly-abnormal-ventilation-perfusion-spect-study-in-idiopathic-pulmonary-arterial-hypertension-without-thromboembolism
#6
Kenneth Chan, John G Coghlan, Margaret Hall, Jamanda Haddock, Alan Bates, Benjamin E Schreiber
Pulmonary hypertension is a serious condition with multiple underlying aetiologies which require different treatment strategies. We present a case of severe idiopathic pulmonary arterial hypertension in a 20-year-old patient with ongoing breathlessness. She was initially diagnosed with asthma and panic attacks in community care. As the symptoms became progressively worse, she was referred for pulmonary hypertension clinic assessment. Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) showed grossly abnormal perfusion defects which were mismatched to the ventilation scan, suggestive of chronic thromboembolic disease...
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29659102/initial-severity-and-antidepressant-efficacy-for-anxiety-disorders-obsessive-compulsive-disorder-and-posttraumatic-stress-disorder-an-individual-patient-data-meta-analysis
#7
Ymkje Anna de Vries, Annelieke M Roest, Johannes G M Burgerhof, Peter de Jonge
BACKGROUND: It has been suggested that antidepressant benefits are smaller for mild than severe depression. Because antidepressants are also used for anxiety disorders, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD), we examined the influence of severity for these disorders. METHODS: We used individual patient data of eight trials (3,430 participants) for generalized anxiety disorder (GAD); four trials (1,195 participants) for social anxiety disorder (SAD); four trials (1,132 participants) for OCD; three trials (1,071 participants) for PTSD; and 10 trials (2,151 participants) for panic disorder (PD)...
April 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29652305/-efficiency-of-neuromultivit-in-complex-therapy-of-patients-with-rheumatoid-arthritis-associated-with-diabetes-mellitus
#8
L N Eliseeva, A Yu Selimov, A Yu Blednova, Zh Z Otarova, M I Bocharnikova, V S Seredinsky
AIM: To examine the dysregulation of the autonomic nervous system and manifestations of pain syndrome in patients with rheumatoid arthritis combined with diabetes mellitus and the possibility of their correction in patients who receive complex therapy including neurotropic vitamins (neuromultivitis). MATERIAL AND METHODS: One hundred and forty-six patients with rheumatoid disease were examined including 59 patients with diabetes mellitus. RESULTS AND CONCLUSION: When testing for the presence of neuropathic pain syndrome using the diagnostic questionnaire of neuropathic pain (DN4), a greater prevalence of these features was revealed, with a high correlation with the duration of rheumatoid arthritis (r=0,56) and duration of diabetes mellitus (r=0,82)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29644077/unusual-presentation-of-pheochromocytoma-thirteen-years-of-anxiety-requiring-psychiatric-treatment
#9
Catherine Alguire, Jessica Chbat, Isabelle Forest, Ariane Godbout, Isabelle Bourdeau
Pheochromocytoma is a rare tumor of the adrenal gland. It often presents with the classic triad of headache, palpitations and generalized sweating. Although not described as a typical symptom of pheochromocytoma, anxiety is the fourth most common symptom reported by patients suffering of pheochromocytoma. We report the case of a 64 year old man who had severe anxiety and panic disorder as presenting symptoms of pheochromocytoma. After 13 years of psychiatric follow-up, the patient was diagnosed with malignant pheochromocytoma...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29623195/is-panic-disorder-a-disorder-of-physical-fitness-a-heuristic-proposal
#10
REVIEW
Giampaolo Perna, Daniela Caldirola
Currently, panic disorder (PD) is considered a mental disorder based on the assumptions that panic attacks (PAs) are "false alarms" that arise from abnormally sensitive defense systems in the central nervous system and that PD is treated with therapies specifically acting on anxiety or fear mechanisms. This article aims to propose an alternative perspective based on the results of some experimental studies. Our heuristic proposal suggests not only that PD may be a mental disorder but also that patients with PD have real abnormal body functioning, mainly involving cardiorespiratory and balance systems, leading to a decline in global physical fitness...
2018: F1000Research
https://www.readbyqxmd.com/read/29620793/antidepressants-versus-placebo-for-panic-disorder-in-adults
#11
REVIEW
Irene Bighelli, Mariasole Castellazzi, Andrea Cipriani, Francesca Girlanda, Giuseppe Guaiana, Markus Koesters, Giulia Turrini, Toshi A Furukawa, Corrado Barbui
BACKGROUND: Panic disorder is characterised by repeated, unexpected panic attacks, which represent a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes, and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. It is common in the general population with a lifetime prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29602786/sensitive-and-specific-recombinase-polymerase-amplification-set-of-assays-for-fast-screening-detection-and-identification-of-bacillus-anthracis-in-a-field-setting
#12
Mostafa Bentahir, Jérôme Ambroise, Cathy Delcorps, Paola Pilo, Jean-Luc Gala
Four isothermal recombinase polymerase amplification assays (RPA) were developed for fast in-field identification of Bacillus (B.) anthracis RPAs targeted three specific sequences (i.e. BA_5345 chromosomal marker, lethal factor lef -pXO1, and capsule biosynthesis capA -pXO2), and a conserved sequence of the B. cereus group in the adenylate cyclase gene ( adk ). B. anthracis -specific RPA assays were first tested on purified genomic DNAs (n=60) containing 11 representatives of B. anthracis , then on soil (n=8) and white powder (n=8) samples spiked with inactivated B...
March 30, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29574383/interplay-between-comt-val158met-childhood-adversities-and-sex-in-predicting-panic-pathology-findings-from-a-general-population-sample
#13
Eva Asselmann, Johannes Hertel, Katja Beesdo-Baum, Carsten-Oliver Schmidt, Georg Homuth, Matthias Nauck, Hans-Jörgen Grabe, Christiane A Pané-Farré
BACKGROUND: The single nucleotide polymorphism rs4680 of the catechol-O-methyltransferase (COMT) gene has been implicated to be involved in the etiopathogenesis of panic. However, it remains unresolved whether rs4680 modifies the risk-association between early life stress and subsequent development of panic pathology. METHODS: The genotype of rs4680 was determined for n = 2242 adults with European ancestry from the Study of Health in Pomerania (SHIP, a regional longitudinal cohort study from northeastern Germany)...
March 8, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29542033/patients-perspective-of-the-impact-of-copd-on-quality-of-life-a-focus-group-study-for-patients-with-copd
#14
Anan Jarab, Eman Alefishat, Tareq Mukattash, Karem Alzoubi, Sharrel Pinto
Background The quality of life has been shown to be poor in patients with chronic obstructive pulmonary disease (COPD). Furthermore, patients' perspective and attitudes toward COPD and its impact on their quality of life have been remarkably ignored. Objective To explore patients' views and perceptions regarding COPD and its impact on their quality of life. Setting COPD clinic at the Royal Medical Services Hospital, Amman, Jordan. Method Focus groups discussions to explore patients' views and perceptions about COPD were conducted using purposive sampling technique till data saturation achieved...
March 14, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29482044/screening-for-panic-related-anxiety-in-emergency-department-patients-with-cardiopulmonary-complaints-a-comparison-of-two-self-report-instruments
#15
Sharon C Sung, Jackie Ma, Arul Earnest, A John Rush, Leslie E C Lim, Marcus E H Ong
The present study examined 1) the accuracy of two self-report measures for detecting panic-related anxiety in emergency department (ED) patients with cardiopulmonary complaints; and 2) whether modified scoring resulted in improved performance. English-speaking adults presenting to the ED of a large public hospital with palpitations, chest pain, dizziness, or difficulty breathing were evaluated for the presence of panic-related anxiety with the Structured Clinical Interview for DSM-IV (SCID) over a one-year period...
May 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29466713/daily-maternal-separations-during-stress-hyporesponsive-period-decrease-the-thresholds-of-panic-like-behaviors-to-electrical-stimulation-of-the-dorsal-periaqueductal-gray-of-the-adult-rat
#16
Ana Cristina Borges-Aguiar, Luana Zanoni Schauffer, Edo Ronald de Kloet, Luiz Carlos Schenberg
The present study examined whether early life maternal separation (MS), a model of childhood separation anxiety, predisposes to panic at adulthood. For this purpose, male pups were submitted to 3-h daily maternal separations along postnatal (PN) days of either the 'stress hyporesponsive period' (SHRP) from PN4 to PN14 (MS11) or throughout lactation from PN2 to PN21 (MS20). Pups were further reunited to conscious (CM) or anesthetized (AM) mothers to assess the effect of mother-pup interaction upon reunion. Controls were subjected to brief handling (15 s) once a day throughout lactation (BH20)...
May 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29456360/clinical-features-and-psychiatric-comorbidity-of-epicrania-fugax
#17
K Rammohan, M M Shyma, Soumitra Das, C Velayudhan Shaji
Background: Epicrania fugax (EF) is a rare newly described primary headache characterized by paroxysms of unilateral pain radiating across one hemicranium. Aim: We aimed to describe 10 new cases of EF and assess the psychiatric comorbidity. Materials and Methods: Cases of EF were identified from patients attending the neurology outpatient department of a tertiary level referral and teaching hospital by the first author during a period extending from January 1, 2015 to April 31, 2017...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29445280/the-differences-between-patients-with-panic-disorder-and-healthy-controls-in-psychophysiological-stress-profile
#18
Antonia Kotianova, Michal Kotian, Milos Slepecky, Michaela Chupacova, Jan Prasko, Ingrid Tonhajzerova
Background: Alarming somatic symptoms, in particular, cardiovascular symptoms, are the characteristic feature of panic attacks. Increased cardiac mortality and morbidity have been found in these patients. Power spectral analysis of electrocardiogram R-R intervals is known to be a particularly successful tool in the detection of autonomic instabilities in various clinical disorders. Our study aimed to compare patients with panic disorder and healthy controls in heart rate variation (HRV) parameters (very-low-frequency [VLF], low-frequency [LF], and high-frequency [HF] band components of R-R interval) in baseline and during the response to the mental task...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29391400/whole-exome-sequencing-and-gene-based-rare-variant-association-tests-suggest-that-pla2g4e-might-be-a-risk-gene-for-panic-disorder
#19
Yoshiro Morimoto, Mihoko Shimada-Sugimoto, Takeshi Otowa, Shintaro Yoshida, Akira Kinoshita, Hiroyuki Mishima, Naohiro Yamaguchi, Takatoshi Mori, Akira Imamura, Hiroki Ozawa, Naohiro Kurotaki, Christiane Ziegler, Katharina Domschke, Jürgen Deckert, Tadashi Umekage, Mamoru Tochigi, Hisanobu Kaiya, Yuji Okazaki, Katsushi Tokunaga, Tsukasa Sasaki, Koh-Ichiro Yoshiura, Shinji Ono
Panic disorder (PD) is characterized by recurrent and unexpected panic attacks, subsequent anticipatory anxiety, and phobic avoidance. Recent epidemiological and genetic studies have revealed that genetic factors contribute to the pathogenesis of PD. We performed whole-exome sequencing on one Japanese family, including multiple patients with panic disorder, which identified seven rare protein-altering variants. We then screened these genes in a Japanese PD case-control group (384 sporadic PD patients and 571 controls), resulting in the detection of three novel single nucleotide variants as potential candidates for PD (chr15: 42631993, T>C in GANC; chr15: 42342861, G>T in PLA2G4E; chr20: 3641457, G>C in GFRA4)...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29374473/epidemiology-of-gastrointestinal-symptoms-in-young-and-middle-aged-swiss-adults-prevalences-and-comorbidities-in-a-longitudinal-population-cohort-over-28-years
#20
Maria Avramidou, Felix Angst, Jules Angst, André Aeschlimann, Wulf Rössler, Ulrich Schnyder
BACKGROUND: Although subacute and chronic gastrointestinal symptoms are very common in primary care, epidemiological date are sparse. The aim of the study was to examine and quantify the prevalence of subacute and chronic gastrointestinal symptoms and their associations with somatic and mental disorders in the general population. METHODS: Data were collected prospectively between 1981 (age m = 22, f = 23) and 2008 (age 49/50) from the Zurich Cohort Study (n = 292 men, 299 women), a representative general population survey...
January 27, 2018: BMC Gastroenterology
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