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https://www.readbyqxmd.com/read/29925786/cyanobacteria-as-nanogold-factories-chemical-and-anti-myocardial-infarction-properties-of-gold-nanoparticles-synthesized-by-lyngbya-majuscula
#1
Esam M Bakir, Nancy S Younis, Maged E Mohamed, Nermin A El Semary
To the best of our knowledge, cyanobacterial strains from the Arabian Gulf have never been investigated with respect to their potential for nanoparticle production. Lyngbya majuscula was isolated from the AlOqair area, Al-Ahsa Government, Eastern Province, Kingdom of Saudi Arabia. The cyanobacterium was initially incubated with 1500 mg/mL of HAuCl₄ for two days. The blue-green strain turned purple, which indicated the intracellular formation of gold nanoparticles. Prolonged incubation for over two months triggered the extracellular production of nanogold particles...
June 20, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29925740/differential-diagnosis-between-catecholaminergic-polymorphic-ventricular-tachycardia-and-long-qt-syndrome-type-1-modified-schwartz-score
#2
Junichi Ozawa, Seiko Ohno, Yusuke Fujii, Takeru Makiyama, Hiroshi Suzuki, Akihiko Saitoh, Minoru Horie
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) has been often misdiagnosed as long QT syndrome (LQTS) type 1 (LQT1), which phenotypically mimics CPVT but has a relatively better prognosis.Methods and Results:The derivation and validation cohorts consisted of 146 and 21 patients, respectively, all of whom had exercise- or emotional stress-induced cardiac events. In the derivation cohort, 42 and 104 patients were first clinically diagnosed with CPVT and LQTS, respectively...
June 21, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29925535/human-induced-pluripotent-stem-cell-derived-engineered-heart-tissue-as-a-sensitive-test-system-for-qt-prolongation-and-arrhythmic-triggers
#3
Marc D Lemoine, Tobias Krause, Jussi T Koivumäki, Maksymilian Prondzynski, Mirja L Schulze, Evaldas Girdauskas, Stephan Willems, Arne Hansen, Thomas Eschenhagen, Torsten Christ
BACKGROUND: Cardiac repolarization abnormalities in drug-induced and genetic long-QT syndrome may lead to afterdepolarizations and life-threatening ventricular arrhythmias. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) should help to overcome the limitations of animal models based on species differences in repolarization reserve. Here, we compared head-to-head the contribution of I Ks (long QT1) and I Kr (long QT2) on action potentials (APs) in human left ventricular (LV) tissue and hiPSC-CM-derived engineered heart tissue (EHT)...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29923812/the-identification-of-torsades-de-pointes-via-ceeg-a-case-report-on-a-patient-with-physiologically-provoked-nonepileptic-events
#4
Andrew Todd Ham, Jill Mackey, Gary Semb
Continuous electroencephalography (CEEG) is chiefly performed at The Medical University of South Carolina (MUSC) for identifying seizures, including its refined use within the epilepsy monitoring unit (EMU) as a differentiator between epileptic and psychogenic etiologies. CEEG also provides critical data that carry implications outside the bounds of both epilepsy and psychogenic events, such as the characterization of unorthodox clinical phenomena that are of physiological (though nonepileptic) origins. Although nonepileptic events (NEEs) are primarily linked with psychogenic phenomena (conversion disorder, malingering) that can mimic epileptic activity, they, like seizures, have diverse semiologies and etiologies...
2018: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29922124/association-between-depression-anxiety-and-antidepressant-use-with-t-wave-amplitude-and-qt-interval
#5
Mandy X Hu, Femke Lamers, Brenda W J H Penninx, Eco J C de Geus
Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval. Methods: Data was obtained from the Netherlands Study of Depression and Anxiety ( n = 1,383). Depression/anxiety was diagnosed with the DSM-IV based Composite International Diagnostic Interview. The use of tricyclic antidepressants (TCAs), selective serotonin and noradrenalin reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs) was established...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29922026/t-wave-alternans-in-long-qt-syndrome
#6
Siddharth Narayan Gadage
Long QT syndrome (LQTS) is a congenital disorder characterized by prolongation of QT interval in the electrocardiogram (ECG) and a propensity to develop ventricular arrhythmias, which may lead to syncope, cardiac arrest or sudden death. T-wave alternans (TWA), a phenomenon of beat-to-beat variability in the repolarization phase of the ventricles, has been closely associated with an increased risk of ventricular tachyarrhythmic events (VTE) and sudden cardiac death (SCD).
May 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29908347/aging-related-functional-and-structural-changes-in-the-heart-and-aorta-mitotempo-improves-aged-cardiovascular-performance
#7
Yusuf Olgar, Sinan Degirmenci, Aysegul Durak, Deniz Billur, Belgin Can, Gizem Kayki Mutlu, Ebru Arioglu Inan, Belma Turan
Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between electrical and mechanical activities in male aged-rats (24-month old) comparison to those of adult-rats (6-month old). We determined significantly increased systemic oxidative stress with decreased antioxidant capacity, clear insulin resistance and hypertrophy in aged-rats with normal fasting blood glucose...
June 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29908011/pretransplant-increases-in-left-ventricular-volume-and-mass-are-associated-with-qt-prolongation-during-pediatric-liver-transplantation
#8
Hyun-Seok Cho, Wook-Jong Kim, Byungdoo Andrew Lee, Junki Cho, Won-Jung Shin, Gyu-Sam Hwang
Structural alterations in the cirrhotic heart may contribute to electromechanical abnormalities, represented by QT prolongation. The aim of this study was to investigate the changes in QTc according to the operative stage during pediatric LT and to identify which baseline echocardiographic parameters were associated with intraoperative QTc prolongation. Data were evaluated from 39 children undergoing LT for chronic liver disease (median age 9 months). In 19 patients (48.7%), baseline QTc was prolonged ≥440 ms (462 ± 19 ms)...
June 15, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29904445/malignant-ventricular-arrhythmias-resulting-from-drug-induced-qtc-prolongation-a-retrospective-study
#9
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
Background: Several drug classes (antiarrhythmics, antimicrobials, antidepressants, phenothiazines, opiates, prokinetics of digestive tract, etc.) have been related to ventricular hyperkinetic arrhythmias such as torsade de pointes (TdP). TdPs are usually heralded by an abnormal prolongation of heart rate-corrected QT interval on the electrocardiogram, so-called drug-induced long heart rate-corrected QT (diLQTc). We don't know to what extent the drug-induced QTc prolongation is able to predict malignant arrhythmias...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29898892/mitochondrial-ros-drive-sudden-cardiac-death-and-chronic-proteome-remodeling-in-heart-failure
#10
Swati Dey, Deeptankar DeMazumder, Agnieszka Sidor, D B Foster, Brian O'Rourke
<u>Rationale:</u> Despite increasing prevalence and incidence of heart failure (HF), therapeutic options remain limited. In early stages of HF, sudden cardiac death (SCD) from ventricular arrhythmias claims many lives. Reactive oxygen species (ROS) have been implicated in both arrhythmias and contractile dysfunction. However, little is known about how ROS in specific subcellular compartments contribute to HF or SCD pathophysiology. The role of ROS in chronic proteome remodeling has not been explored...
June 13, 2018: Circulation Research
https://www.readbyqxmd.com/read/29898699/rapid-calcium-loss-may-cause-arrhythmia-in-hemofiltration-with-regional-citrate-anticoagulation-a-case-report
#11
Buyun Wu, Jing Wang, Guang Yang, Changying Xing, Huijuan Mao
BACKGROUND: Renal replacement therapy (RRT) with regional citrate anticoagulation (RCA) is an important therapeutic approach for refractory hypercalcemia complicated with renal failure. However, RCA has the potential to induce arrhythmia caused by rapid calcium loss. We report a case of arrhythmia associated with rapid calcium loss during RCA-RRT. CASE PRESENTATION: A 51-year-old man with hypercalcemia, primary hyperparathyroidism, and acute kidney injury was treated by predilutional-RCA-hemofiltration at a rate of 4...
June 14, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29898002/qtc-interval-prolongation-in-critically-ill-patients-prevalence-risk-factors-and-associated-medications
#12
Flávia Medeiros Fernandes, Eliane Pereira Silva, Rand Randall Martins, Antonio Gouveia Oliveira
PURPOSE: To investigate the prevalence and risk factors of acquired long QT syndrome (LQTS) on admission to a general Intensive Care Unit (ICU), and to assess the risk of LQTS associated with prescribed medications. METHODS: Prospective observational, cross-sectional study approved by the Institutional Review Board. Between May 2014 and July 2016, 412 patients >18 years-old consecutively admitted to the ICU of a university hospital were included. LQTS was defined as a QT interval on the admission electrocardiogram corrected using Bazett's formula (QTc) >460 ms for men and >470 ms for women...
2018: PloS One
https://www.readbyqxmd.com/read/29894447/corrected-qt-interval-prolongation-in-hospitalized-pediatric-patients-receiving-methadone
#13
Amy J Schwinghammer, Machelle D Wilson, Brent A Hall
OBJECTIVES: Methadone is often used in pediatric patients to prevent or treat opioid withdrawal after prolonged sedation. Prolonged corrected QT interval is an important adverse effect of methadone because it can progress to torsades de pointes, a potentially fatal dysrhythmia. The prevalence of corrected QT interval prolongation and contributing risk factors are not well defined in hospitalized pediatric patients receiving methadone. The study purpose was to identify the frequency and risk factors of corrected QT interval prolongation in hospitalized pediatric patients receiving methadone...
June 11, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29887480/a-wearable-remote-monitoring-system-for-the-identification-of-subjects-with-a-prolonged-qt-interval-or-at-risk-for-drug-induced-long-qt-syndrome
#14
Silvia Castelletti, Federica Dagradi, Karine Goulene, Aurora I Danza, Enrico Baldi, Marco Stramba-Badiale, Peter J Schwartz
BACKGROUND: A correct measurement of the QT interval in the out-of-hospital setting is important whenever the long QT syndrome (LQTS) is suspected or a therapy might lead to drug-induced LQTS (diLQTS) because QT interval monitoring in the initial days of therapy could alert to dangerous QT prolongation. We explored whether automated QTc measurements (BGM) by BodyGuardian™ (BG), a wearable remote monitoring system, are sufficiently reliable compared to our own manual measurements (MM) performed on the same beats during 12‑lead Holter recordings in LQTS patients (pts) and in healthy controls...
September 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29887371/risk-of-sudden-unexplained-death-after-use-of-dihydroartemisinin-piperaquine-for-malaria-a-systematic-review-and-bayesian-meta-analysis
#15
Xin Hui S Chan, Yan Naung Win, Laura J Mawer, Jireh Y Tan, Josep Brugada, Nicholas J White
BACKGROUND: Dihydroartemisinin-piperaquine is an effective and well tolerated artemisinin-based combination therapy that has been assessed extensively for the prevention and treatment of malaria. Piperaquine, similar to several structurally related antimalarials currently used, can prolong cardiac ventricular repolarisation duration and the electrocardiographic QT interval, leading to concerns about its proarrhythmic potential. We aimed to assess the risk of potentially lethal iatrogenic ventricular arrhythmias in individuals receiving dihydroartemisinin-piperaquine...
June 7, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29887217/addition-of-digoxin-improves-cardiac-function-in-children-with-the-dilated-cardiomyopathy-with-ataxia-syndrome-a-mitochondrial-cardiomyopathy
#16
Steven C Greenway, Frederic Dallaire, Hassan Hazari, Dhwani Patel, Aneal Khan
BACKGROUND: The dilated cardiomyopathy with ataxia syndrome (DCMA) is a rare mitochondrial disorder characterized by progressive cardiomyopathy, prolonged QT interval and early death in childhood related to intractable heart failure. We present a case series of 9 children with DCMA who demonstrated functional improvement and favourable left ventricular remodeling only after digoxin was added to their medical therapy. METHODS: A retrospective review of 46 patients with DCMA followed at the Alberta Children's Hospital from 2005 to 2017 identified 9 patients who were treated with digoxin and had serial echocardiography data...
March 1, 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29882591/predictive-analytics-for-identification-of-patients-at-risk-for-qt-interval-prolongation-a-systematic-review
#17
Elena Tomaselli Muensterman, James E Tisdale
Prolongation of the heart rate-corrected QT (QTc) interval increases the risk for torsades de pointes (TdP), a potentially fatal arrhythmia. The likelihood of TdP is higher in patients with risk factors, which include female sex, older age, heart failure with reduced ejection fraction, hypokalemia, hypomagnesemia, concomitant administration of ≥ 2 QTc interval-prolonging medications, among others. Assessment and quantification of risk factors may facilitate prediction of patients at highest risk for developing QTc interval prolongation and TdP...
June 8, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29879475/challenges-in-implementing-and-obtaining-acceptance-for-j-tpeak-assessment-as-the-clinical-component-of-cipa
#18
Borje Darpo, Jean-Philippe Couderc
INTRODUCTION: This paper is based on a presentation held at the Annual Safety Pharmacology Society meeting in September 2017, at which challenges for the clinical component of CiPA were presented. FDA has published an automated algorithm for measurement of the J-Tpeak interval on a median beat from a vector magnitude lead derived from a 12-lead ECG. CiPA proposes that J-Tpeak prolongation < 10 ms can be used for drugs with a QTc effect < 20 ms to differentiate between safe and unsafe delayed repolarization and to reduce the level of ECG monitoring in late stage clinical trials...
June 4, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29876021/anticancer-drugs-related-qtc-prolongation-torsade-de-pointes-and-sudden-death-current-evidence-and-future-research-perspectives
#19
REVIEW
Jialin Duan, Jingwen Tao, Maocai Zhai, Chengpeng Li, Ning Zhou, Jiagao Lv, Lin Wang, Li Lin, Rong Bai
Anticancer drugs may have proarrhythmic effects including drug-induced QT interval prolongation, which is of particular importance because it can lead to a fatal polymorphic ventricular tachycardia termed torsade de pointes (TdP). QT interval prolongation and TdP are rare life-threatening untoward effects of anticancer therapy, particularly with arsenic trioxides and anthracyclines, and even some novel molecular targeted drugs touted as 'tumor specific'. Several factors that affect myocardial repolarization can further increase the risk of TdP...
May 22, 2018: Oncotarget
https://www.readbyqxmd.com/read/29874175/exomechip-wide-analysis-of-95-626-individuals-identifies-10-novel-loci-associated-with-qt-and-jt-intervals
#20
Nathan A Bihlmeyer, Jennifer A Brody, Albert Vernon Smith, Helen R Warren, Honghuang Lin, Aaron Isaacs, Ching-Ti Liu, Jonathan Marten, Farid Radmanesh, Leanne M Hall, Niels Grarup, Hao Mei, Martina Müller-Nurasyid, Jennifer E Huffman, Niek Verweij, Xiuqing Guo, Jie Yao, Ruifang Li-Gao, Marten van den Berg, Stefan Weiss, Bram P Prins, Jessica van Setten, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Man Li, Alvaro Alonso, Elsayed Z Soliman, Joshua C Bis, Tom Austin, Yii-Der Ida Chen, Bruce M Psaty, Tamara B Harrris, Lenore J Launer, Sandosh Padmanabhan, Anna Dominiczak, Paul L Huang, Zhijun Xie, Patrick T Ellinor, Jan A Kors, Archie Campbell, Alison D Murray, Christopher P Nelson, Martin D Tobin, Jette Bork-Jensen, Torben Hansen, Oluf Pedersen, Allan Linneberg, Moritz F Sinner, Annette Peters, Melanie Waldenberger, Thomas Meitinger, Siegfried Perz, Ivana Kolcic, Igor Rudan, Rudolf A de Boer, Peter van der Meer, Henry J Lin, Kent D Taylor, Renée de Mutsert, Stella Trompet, J Wouter Jukema, Arie C Maan, Bruno H C Stricker, Fernando Rivadeneira, André Uitterlinden, Uwe Völker, Georg Homuth, Henry Völzke, Stephan B Felix, Massimo Mangino, Timothy D Spector, Michiel L Bots, Marco Perez, Olli T Raitakari, Mika Kähönen, Nina Mononen, Vilmundur Gudnason, Patricia B Munroe, Steven A Lubitz, Cornelia M van Duijn, Christopher H Newton-Cheh, Caroline Hayward, Jonathan Rosand, Nilesh J Samani, Jørgen K Kanters, James G Wilson, Stefan Kääb, Ozren Polasek, Pim van der Harst, Susan R Heckbert, Jerome I Rotter, Dennis O Mook-Kanamori, Mark Eijgelsheim, Marcus Dörr, Yalda Jamshidi, Folkert W Asselbergs, Charles Kooperberg, Terho Lehtimäki, Dan E Arking, Nona Sotoodehnia
BACKGROUND: QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular repolarization alone. Prolonged QT interval has been linked to higher risk of sudden cardiac arrest. METHODS AND RESULTS: We performed an ExomeChip-wide analysis for both QT and JT intervals, including 209 449 variants, both common and rare, in 17 341 genes from the Illumina Infinium HumanExome BeadChip...
January 2018: Circulation. Genomic and precision medicine
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