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Hand foot and mouth disease

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https://www.readbyqxmd.com/read/29324904/prohibitin-plays-a-critical-role-in-enterovirus-71-neuropathogenesis
#1
Issac Horng Khit Too, Isabelle Bonne, Eng Lee Tan, Justin Jang Hann Chu, Sylvie Alonso
A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children. Our limited understanding of the mechanisms involved in its neuropathogenesis has hampered the development of effective therapeutic options. Here, using a two-dimensional proteomics approach combined with mass spectrometry, we have identified a unique panel of host proteins that were differentially and dynamically modulated during EV71 infection of motor-neuron NSC-34 cells, which are found at the neuromuscular junctions where EV71 is believed to enter the central nervous system...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29323107/serological-survey-of-neutralizing-antibodies-to-eight-major-enteroviruses-among-healthy-population
#2
Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He, Ningshao Xia
Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29319516/genetic-characterization-of-human-enteroviruses-associated-with-hand-foot-and-mouth-diseases-in-poland-2013-2016
#3
Magdalena Wieczorek, Agnieszka Ciąćka, Arleta Krzysztoszek, Agnieszka Figas, Leszek Szenborn
The objective of the present study was to describe the molecular characteristics of enteroviruses associated with hand, food, and mouth disease (HFMD) in Poland. Clinical material from HFMD cases, that occurred during 2013-2016 were examined. It has been showed that coxsackievirus A6 (CVA6), CVA10 and CVA16 were circulating in the country. Phylogenetic analysis showed that Polish CVA6 strains were divided into two distinct clusters suggesting two independent introductions. This is the first report of CVA6 infections associated with HFMD in Poland...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29311608/a-novel-rat-cvb1-vp1-monoclonal-antibody-3a6-detects-a-broad-range-of-enteroviruses
#4
Niila V V Saarinen, Jutta E Laiho, Sarah J Richardson, Marie Zeissler, Virginia M Stone, Varpu Marjomäki, Tino Kantoluoto, Marc S Horwitz, Amirbabak Sioofy-Khojine, Anni Honkimaa, Minna M Hankaniemi, Malin Flodström-Tullberg, Heikki Hyöty, Vesa P Hytönen, Olli H Laitinen
Enteroviruses (EVs) are common RNA viruses that cause diseases ranging from rash to paralytic poliomyelitis. For example, EV-A and EV-C viruses cause hand-foot and mouth disease and EV-B viruses cause encephalitis and myocarditis, which can result in severe morbidity and mortality. While new vaccines and treatments for EVs are under development, methods for studying and diagnosing EV infections are still limited and therefore new diagnostic tools are required. Our aim was to produce and characterize new antibodies that work in multiple applications and detect EVs in tissues and in vitro...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310596/different-responses-of-weather-factors-on-hand-foot-and-mouth-disease-in-three-different-climate-areas-of-gansu-china
#5
Faxiang Gou, Xinfeng Liu, Jian He, Dongpeng Liu, Yao Cheng, Haixia Liu, Xiaoting Yang, Kongfu Wei, Yunhe Zheng, Xiaojuan Jiang, Lei Meng, Wenbiao Hu
BACKGROUND: To determine the linear and non-linear interacting relationships between weather factors and hand, foot and mouth disease (HFMD) in children in Gansu, China, and gain further traction as an early warning signal based on weather variability for HFMD transmission. METHOD: Weekly HFMD cases aged less than 15 and meteorological information from 2010 to 2014 in Jiuquan, Lanzhou and Tianshu, Gansu, China were collected. Generalized linear regression models (GLM) with Poisson link and classification and regression trees (CART) were employed to determine the combined and interactive relationship of weather factors and HFMD in both linear and non-linear ways...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29306826/ambient-temperature-humidity-and-hand-foot-and-mouth-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
Qiang Cheng, Lijun Bai, Yanwu Zhang, Heng Zhang, Shusi Wang, Mingyu Xie, Desheng Zhao, Hong Su
BACKGROUND: The relationship between ambient temperature, humidity and hand, foot, and mouth disease (HFMD) has been highlighted in East and Southeast Asia, which showed multiple different results. Therefore, our goal is to conduct a meta-analysis to further clarify this relationship and to quantify the size of these effects as well as the susceptible populations. METHODS: PubMed, Web of science, and Cochrane library were searched up to November 22, 2017 for articles analyzing the relationships between ambient temperature, humidity and incidence of HFMD...
January 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29298696/enhanced-human-enterovirus-71-infection-by-endocytosis-inhibitors-reveals-multiple-entry-pathways-by-enterovirus-causing-hand-foot-and-mouth-diseases
#7
Meichun Yuan, Jingjing Yan, Jingna Xun, Chong Chen, Yuling Zhang, Min Wang, Wenqi Chu, Zhigang Song, Yunwen Hu, Shuye Zhang, Xiaoyan Zhang
BACKGROUND: Human enterovirus 71 (EV71) was previously known to enter cells through clathrin or caveolar mediated endocytic pathways. However, we observed chlorpromazine (CPZ) or dynasore (DNS), which inhibit clathrin and dynamin mediated endocytosis, did not suppress EV71 cell entry in particular cell types. So the current knowledge of entry mechanisms by EV71 is not complete. METHODS: Viral infection was examined by flow cytometry or end-point dilution assays...
January 3, 2018: Virology Journal
https://www.readbyqxmd.com/read/29291236/clinical-characteristics-of-hand-foot-and-mouth-disease-in-daklak-province-vietnam-and-associated-factors-of-severe-cases
#8
Hau Van Pham, Tuan N A Hoang, Hao T Duong, Lan T Phan, Uyen T N Phan, Nguyen X Ho, Cuong Q Hoang
The Hand, Foot and Mouth Disease (HFMD) outbreaks occurred throughout Daklak province, Vietnam in 2011. This study reviewed all 744 medical records of HFMD patients admitted to Daklak Hospital in 2011 to describe the clinical characteristics of HFMD patients and determined factors associated with severe illness. Among 744 patients, 63 (8.5%) cases were severe. Most (695, 93.4%) of the cases were 3 years old or younger, and 464 (62.4%) were boys. The number of cases peaked between August and November. Most (726, 97...
December 2017: Virusdisease
https://www.readbyqxmd.com/read/29282065/pulmonary-edema-following-central-nervous-system-lesions-induced-by-a-non-mouse-adapted-ev71-strain-in-neonatal-balb-c-mice
#9
Yuefei Jin, Chao Zhang, Rongguang Zhang, Jingchao Ren, Shuaiyin Chen, Meili Sui, Guangyuan Zhou, Dejian Dang, Jiehui Zhu, Huifen Feng, Yuanlin Xi, Haiyan Yang, Guangcai Duan
BACKGROUND: Enterovirus (EV) infection has been a serious health issue in Asia-Pacific region. It has been indicated that the occurrence of fatal hand foot and mouth disease (HFMD) cases following EV71 infection is mainly attributed to pulmonary edema. However, the development of pulmonary disorders after EV71 infection remains largely unknown. To establish an EV71-infected animal model and further explore the underlying association of central nervous system (CNS) invasion with pulmonary edema, we isolated a clinical source EV71 strain (ZZ1350) from a severe case in Henan Province...
December 28, 2017: Virology Journal
https://www.readbyqxmd.com/read/29273280/epidemix-an-interactive-multi-model-application-for-teaching-and-visualizing-infectious-disease-transmission
#10
Ulrich Muellner, Guillaume Fournié, Petra Muellner, Christina Ahlstrom, Dirk U Pfeiffer
Mathematical models of disease transmission are used to improve our understanding of patterns of infection and to identify factors influencing them. During recent public and animal health crises, such as pandemic influenza, Ebola, Zika, foot-and-mouth disease, models have made important contributions in addressing policy questions, especially through the assessment of the trajectory and scale of outbreaks, and the evaluation of control interventions. However, their mathematical formulation means that they may appear as a "black box" to those without the appropriate mathematical background...
December 11, 2017: Epidemics
https://www.readbyqxmd.com/read/29258646/epidemiology-of-hand-foot-and-mouth-disease-in-china-2008-to-2015-prior-to-the-introduction-of-ev-a71-vaccine
#11
Bingyi Yang, Fengfeng Liu, Qiaohong Liao, Peng Wu, Zhaorui Chang, Jiao Huang, Lu Long, Li Luo, Yu Li, Gabriel M Leung, Benjamin J Cowling, Hongjie Yu
IntroductionHand, foot and mouth disease (HFMD) is usually caused by several serotypes from human enterovirus A species, including enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). Two inactivated monovalent EV-A71 vaccines have been recently licensed in China and monovalent CV-A16 vaccine and bivalent EV-A71 and CV-A16 vaccine are under development. Methods: Using notifications from the national surveillance system, we describe the epidemiology and dynamics of HFMD in the country, before the introduction of EV-A71 vaccination, from 2008 through 2015...
December 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29245260/risk-factors-for-death-in-children-with-critical-and-severe-hand-foot-and-mouth-disease-in-chongqing-china-an-observational-study
#12
Gaihuan Zheng, Jiaoyang Cao, Jie Yu, Zhenzhen Zhang, Quanbo Liu, Junhua Chen
Hand-foot-and-mouth disease (HFMD) is a common childhood infection that may lead to serious complications and even death. Globally, epidemics of HFMD are increasing each year, especially in China. This study aimed to identify risk factors for death in children with critical and severe HFMD in Chongqing, China.We performed an observational study involving patients with critical and severe HFMD admitted to the Children's Hospital of Chongqing Medical University from January 2009 to December 2016. Overall, 179 patients aged 2 months to 16 years, were included; 127 died (non-survival group) and 52 survived (survival group); the case-fatality rate was 70...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29242411/a-retrospective-study-of-331-deaths-in-children-with-severe-hand-foot-and-mouth-disease-in-guangxi-china
#13
Zhi-Yong Yang, Xiu-Qi Chen, Dan Sun, Dan Wei
OBJECTIVE: To analyze the clinical features of children with hand foot and mouth disease (HFMD) who died. METHODS: 331 deaths due to HFMD were included in this retrospective study; 15 autopsies were performed. RESULTS: Most cases were seen in children aged below 3 years, and with enterovirus 71 infection (91%). The mean (SD) duration of HFMD from onset to death was 3.7(2.9) days. The mean (SD) age of fast progressors (from onset to death less than 4 days) was 17...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29238324/immunopathogenesis-and-virus-host-interactions-of-enterovirus-71-in-patients-with-hand-foot-and-mouth-disease
#14
REVIEW
Jonathan A Cox, Julian A Hiscox, Tom Solomon, Mong-How Ooi, Lisa F P Ng
Enterovirus 71 (EV71) is a global infectious disease that affects millions of people. The virus is the main etiological agent for hand, foot, and mouth disease with outbreaks and epidemics being reported globally. Infection can cause severe neurological, cardiac, and respiratory problems in children under the age of 5. Despite on-going efforts, little is known about the pathogenesis of EV71, how the host immune system responds to the virus and the molecular mechanisms behind these responses. Moreover, current animal models remain limited, because they do not recapitulate similar disease patterns and symptoms observed in humans...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29235129/association-of-gene-polymorphisms-of-pattern-recognition-receptor-signalling-pathway-with-the-risk-and-severity-of-hand-foot-and-mouth-disease-caused-by-enterovirus-71-in-chinese-han-population
#15
Ya-Ping Li, Mei Li, Xiao-Li Jia, Hui-Ling Deng, Wen-Jun Wang, Feng-Ping Wu, Jun Wang, Shuang-Suo Dang
Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex- and age-matched children was included as a control...
December 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29233744/a-flavonoid-compound-library-screen-revealed-potent-antiviral-activity-of-plant-derived-flavonoids-on-human-enterovirus-a71-replication
#16
Nyo Min, Leong Pok Thim, Regina Ching Hua Lee, Jeffery Seng Eng Khuan, Justin Jang Hann Chu
Hand Foot Mouth Disease (HFMD), resulting from human enterovirus A71 (HEVA71) infection can cause severe neurological complications leading to fatality in young children. Currently, there is no approved antiviral for therapeutic treatment against HEVA71 infection. In this study, a 500-compound flavonoid library was screened to identify potential inhibitors of HEVA71 using high-throughput immunofluorescence-based phenotypic screening method. Two lead flavonoid compounds, ST077124 and ST024734 at the non-cytotoxic concentration of 50 μM were found to be effective antivirals that inhibited replication of HEVA71, reducing infectious viral titers by 3...
December 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29231065/serum-interleukin-6-levels-as-an-indicator-of-aseptic-meningitis-among-children-with-enterovirus-71-induced-hand-foot-and-mouth-disease
#17
Joo Young Lee, Minji Son, Jin Han Kang, Ui Yoon Choi
OBJECTIVES: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. It is often performed based on physicians' clinical suspicion. A diagnostic method that can aid in deciding whether this procedure should be performed is necessary. Cytokines are speculated to be associated with neurologic complications...
December 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29216216/epidemiological-and-genetic-characteristics-of-ev71-in-hand-foot-and-mouth-disease-in-guangxi-southern-china-from-2010-to-2015
#18
Minmei Chen, Yu Ju, Min Chen, Zhenguo Xie, Kaijiao Zhou, Yi Tan, Jianjun Mo
Hand, foot, and mouth disease (HFMD) is a significant public health challenge in China. Human enterovirus 71 (EV71) is regarded as the predominant causative pathogen of HFMD. Since 2015, two inactivated EV71 vaccines have been approved in mainland China, and because their use could change the HFMD pathogen spectrum, this should now be monitored. However, the epidemiological and genetic trends of EV71 with respect to HFMD in Guangxi, southern China, are still not clear. In this study, we describe the epidemiological and genetic characterization of this virus in clinically-diagnosed HFMD reported from 2010 to 2015 in Guangxi...
2017: PloS One
https://www.readbyqxmd.com/read/29184105/estimating-the-incubation-period-of-hand-foot-and-mouth-disease-for-children-in-different-age-groups
#19
Zhongzhou Yang, Qiqi Zhang, Benjamin J Cowling, Eric H Y Lau
Hand, foot and mouth disease (HFMD) is a childhood disease causing large outbreaks frequently in Asia and occasionally in Europe and the US. The incubation period of HFMD was typically described as about 3-7 days but empirical evidence is lacking. In this study, we estimated the incubation period of HFMD from school outbreaks in Hong Kong, utilizing information on symptom onset and sick absence dates of students diagnosed with HFMD. A total of 99 HFMD cases from 12 schools were selected for analysis. We fitted parametric models accounting for interval censoring...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29182793/atypical-hand-foot-and-mouth-disease-caused-by-coxsackievirus-a6-in-denmark-a-diagnostic-mimicker
#20
Hans-Henrik Horsten, Michael Kemp, Thea K Fischer, Kim H Lindahl, Anette Bygum
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Dermatology Department at a regional University Hospital in Denmark. Patients were referred by general practitioners and dermatologists with a variety of clinical diagnoses, including eczema herpeticum, vasculitis, syphilis, dermatophytid, erythema multiforme and Stevens-Johnson syndrome...
November 28, 2017: Acta Dermato-venereologica
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