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Hand foot and mouth disease

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https://www.readbyqxmd.com/read/28914333/-acute-skin-infections-and-their-imitators-in-children-a-photo-quiz
#1
REVIEW
M Theiler, A Schwieger-Briel, L Weibel
BACKGROUND: Skin infections account for 40% of emergency visits in pediatric dermatology. It is important to promptly recognize skin infections with potential complications and initiate treatment. However some characteristic skin findings may imitate skin infections and are often misdiagnosed. OBJECTIVES: To illustrate frequent pediatric skin infections and pitfalls in view of imitators and differential diagnoses. MATERIALS AND METHODS: A photo quiz is presented with the discussion of a selection of acute pediatric skin infections in comparison to their infectious or noninfectious differential diagnoses...
September 15, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28910932/-downscaling-research-of-spatial-distribution-of-incidence-of-hand-foot-and-mouth-disease-based-on-area-to-area-poisson-kriging-method
#2
J X Wang, M G Hu, S C Yu, G X Xiao
Objective: To understand the spatial distribution of incidence of hand foot and mouth disease (HFMD) at scale of township and provide evidence for the better prevention and control of HFMD and allocation of medical resources. Methods: The incidence data of HFMD in 108 counties (district) in Shandong province in 2010 were collected. Downscaling interpolation was conducted by using area-to-area Poisson Kriging method. The interpolation results were visualized by using geographic information system (GIS). The county (district) incidence was interpolated into township incidence to get the distribution of spatial distribution of incidence of township...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28898935/monitoring-hand-foot-and-mouth-disease-by-combining-search-engine-query-data-and-meteorological-factors
#3
Da-Cang Huang, Jin-Feng Wang
Hand, foot and mouth disease (HFMD) has been recognized as a significant public health threat and poses a tremendous challenge to disease control departments. To date, the relationship between meteorological factors and HFMD has been documented, and public interest of disease has been proven to be trackable from the Internet. However, no study has explored the combination of these two factors in the monitoring of HFMD. Therefore, the main aim of this study was to develop an effective monitoring model of HFMD in Guangzhou, China by utilizing historical HFMD cases, Internet-based search engine query data and meteorological factors...
September 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28894095/atomic-structures-of-coxsackievirus-a6-and-its-complex-with-a-neutralizing-antibody
#4
Longfa Xu, Qingbing Zheng, Shaowei Li, Maozhou He, Yangtao Wu, Yongchao Li, Rui Zhu, Hai Yu, Qiyang Hong, Jie Jiang, Zizhen Li, Shuxuan Li, Huan Zhao, Lisheng Yang, Wangheng Hou, Wei Wang, Xiangzhong Ye, Jun Zhang, Timothy S Baker, Tong Cheng, Z Hong Zhou, Xiaodong Yan, Ningshao Xia
Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates. Despite the presence (in A-particle) or absence (in procapsid) of capsid-RNA interactions, the two CVA6 particles have essentially identical atomic capsid structures resembling the uncoating intermediates of other enteroviruses...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28893485/-clinical-characteristics-and-course-of-hand-foot-and-mouth-disease
#5
A Mirand, H Peigue-Lafeuille
Hand, foot and mouth disease (HFMD) and herpangina (HA) are common childhood diseases mostly associated with human enteroviruses (EV). Although usually benign illnesses, neurological complications may be observed during large epidemics when enterovirus A71 (EV-A71) is involved, as observed in the Asia Pacific Region and in China since the late 1990s. The occurrence of these complications warrants reinforcing the surveillance of the emergence of EV-A71 infections in France and Europe. Monitoring EV infections associated with HFMD can be considered as an effective tool to detect an upsurge of EV-A71 infections in a timely manner...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28892475/cost-effectiveness-of-a-national-enterovirus-71-vaccination-program-in-china
#6
Wenjun Wang, Jianwen Song, Jingjing Wang, Yaping Li, Huiling Deng, Mei Li, Ning Gao, Song Zhai, Shuangsuo Dang, Xin Zhang, Xiaoli Jia
BACKGROUND AND AIMS: Enterovirus 71 (EV71) has caused great morbidity, mortality, and use of health service in children younger than five years in China. Vaccines against EV71 have been proved effective and safe by recent phase 3 trials and are now available in China. The purpose of this study was to evaluate the health impact and cost-effectiveness of a national EV71 vaccination program in China. METHODS: Using Microsoft Excel, a decision model was built to calculate the net clinical and economic outcomes of EV71 vaccination compared with no EV71 vaccination in a birth cohort of 1,000,000 Chinese children followed for five years...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28891456/spatiotemporal-risk-mapping-of-hand-foot-and-mouth-disease-and-its-association-with-meteorological-variables-in-children-under-5-years
#7
C D Xu, G X Xiao
Hand, foot and mouth disease (HFMD) risk has become an increasing concern in the Beijing-Tianjin-Hebei region, which is the biggest urban agglomeration in north-eastern Asia. In the study, spatiotemporal epidemiological features of HFMD were analysed, and a Bayesian space-time hierarchy model was used to detect local spatial relative risk (RR) and to assess the effect of meteorological factors. From 2009 to 2013, there was an obvious seasonal pattern of HFMD risk. The highest risk period was in the summer, with an average monthly incidence of 4·17/103, whereas the index in wintertime was 0·16/103...
September 11, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28890503/spatial-clustering-of-severe-hand-foot-mouth-disease-cases-in-hainan-island-china
#8
Shao-Ming Chen, Li Qiu, Zhong-Hua Du, Yu-Ming Jin, Jian-Wei Du, Yan Chen, Chiho Watanabe, Masahiro Umezaki
  The incidence of severe Hand-Foot-Mouth disease (HFMD) in Southeast/East Asia has recently increased. This study explored spatial clusters of the incidence and proportion of severe HFMD cases in Hainan Island, Where the prevalence and mortality of HFMD were the highest in China in 2011. A spatial autocorrelation statistic (Anselin's Local Moran I) was calculated for the Empirical Bayesian (EB) smoothed dataset of severe HFMD cases. Significantly spatial clusters were detected for both incidence and the proportion of severe HFMD cases...
September 11, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28882666/clinical-features-for-89-deaths-of-hand-foot-and-mouth-disease-in-guangxi-china-2014
#9
Wei Lin, Ying Su, Min Jiang, Jing Liu, Yan-Yan Zhang, Guang-Min Nong
OBJECTIVES: The aim of this study is to summarize the risk factors of severe Hand, foot and mouth disease (HFMD) and explore the clinical characteristics of pulmonary edema (PE) and non-PE in the expired patients with HFMD. METHODS: We identified 89 HFMD deaths which were separated into the PE group or non-PE group. Next, patients were divided based on their initial admission to hospitals as stage 1, 2, 3, or 4; at this point, their clinical manifestations were compared...
September 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28871120/development-of-a-luciferase-based-biosensor-to-assess-enterovirus-71-3c-protease-activity-in-living-cells
#10
Yuan Zhang, Xianliang Ke, Caishang Zheng, Yan Liu, Li Xie, Zhenhua Zheng, Hanzhong Wang
Enterovirus 71 (EV71) is a major pathogen of hand, foot, and mouth disease (HFMD). To date, no antiviral drug has been approved to treat EV71 infection. Due to the essential role that EV71 3 C protease (3C(pro)) plays in the viral life cycle, it is generally considered as a highly appealing target for antiviral drug development. In this study, we present a transgene-encoded biosensor that can accurately, sensitively and quantitatively report the proteolytic activity of EV71 3C(pro). This biosensor is based on the catalyzed activity of a pro-interleukin (IL)-1β-enterovirus 3C(pro) cleavage site-Gaussia Luciferase (GLuc) fusion protein that we named i-3CS-GLuc...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867629/a-nanobiosensing-method-based-on-force-measurement-of-antibody-antigen-interaction-for-direct-detection-of-enterovirus-71-by-the-chemically-modified-atomic-force-microscopic-probe
#11
Chung-Hung Hong, Chung-Fan Hsieh, Chi-Shin Tseng, Wei-Chih Huang, Cheng-Yan Guo, Shiming Lin, Si-Chen Lee
Hand, Foot and mouth disease (HFMD) is a common disease with high infectivity for children, and enterovirus 71 (EV71) is one of the main pathogens to cause the type of illness. Therefore, the aim of this study was to propose a rapid and effective technique for detecting EV71 directly based on the mechanism of biological intermolecular force by using atomic force microscopy (AFM). At first, we coated EV71 particles on the mica surface and made the EV71 antibodies (anti-EV71) fixed on the AFM tip by means of several chemical procedures...
September 1, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28866699/a-sudden-paediatric-death-due-to-hand-foot-and-mouth-disease-the-importance-of-vigilance
#12
R Rahimi, E Omar, T S Tuan Soh, S F A Mohd Nawi, S Md Noor
BACKGROUND: Hand, foot and mouth disease (HFMD) is caused by enteroviruses such as Coxsackie virus A16 (CVA16) and Enterovirus 71 (EV71). The diagnostic hallmarks are oral ulcers and maculo-papular or vesicular rash on the hands and feet. Severe form of this disease can lead to death due to neurological and cardiopulmonary complications. This case report aims to describe a fatal case of HFMD with minimal oral and skin manifestations. CASE REPORT: A four-year-old girl was brought to a hospital after suddenly becoming unresponsive at home...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28864155/large-scale-hfmd-epidemics-caused-by-coxsackievirus-a16-in-bangalore-india-during-2013-and-2015
#13
Rao C Durga, Naidu R Jagadeesh, Maiya P Padmanabha, M Ananda Babu, Bailly Jean-Luc
Hand foot and mouth disease (HFMD) is a relatively unreported disease in India. This study was undertaken to characterize the enterovirus type/s associated with two unexpectedly-massive epidemics that occurred in Bangalore, India in 2013 and 2015. Stool samples of 229 children with HFMD living in Northern and Southern areas of Bangalore were tested by RT-PCR; 189 (82.5%) were enterovirus positive. The Indian CV-A16 strains exhibited 98-99% sequence identity with those reported in France and China in the 5' untranslated region...
August 29, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28854257/hrs-plays-an-important-role-for-tlr7-signaling-to-orchestrate-inflammation-and-innate-immunity-upon-ev71-infection
#14
Zhen Luo, Maolin Ge, Junbo Chen, Qibin Geng, Mingfu Tian, Zhi Qiao, Lan Bai, Qi Zhang, Chengliang Zhu, Ying Xiong, Kailang Wu, Fang Liu, Yingle Liu, Jianguo Wu
Enterovirus 71 (EV71) is an RNA virus that causes hand-foot-mouth disease (HFMD), and even fatal encephalitis in children. Although EV71 pathogenesis remains largely obscure, host immune responses may play important roles in the development of diseases. Recognition of pathogens mediated by Toll-like receptors (TLRs) induces host immune and inflammatory responses. Intracellular TLRs must traffic from the endoplasmic reticulum (ER) to the endolysosomal network from where they initiate complete signaling, leading to inflammatory response...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28845247/a52%C3%A2-development-and-evaluation-of-a-viral-specific-random-pcr-and-next-generation-sequencing-based-assay-for-detection-and-sequencing-of-hand-foot-and-mouth-disease-pathogens
#15
Nguyen To Anh, Tran Tan Thanh, Hoang Minh Tu Van, Nghiem My Ngoc, Le Nguyen Truc Nhu, Le Thi My Thanh, Phan Tu Qui, Truong Huu Khanh, Le Nguyen Thanh Nhan, Ho Lu Viet, Do Chau Viet, Ha Manh Tuan, Nguyen Thanh Hung, Nguyen Van Vinh Chau, Guy Thwaites, H Rogier van Doorn, Le Van Tan
No abstract text is available yet for this article.
March 2017: Virus Evolution
https://www.readbyqxmd.com/read/28843383/il-10-592-polymorphism-is-associated-with-il-10-expression-and-severity-of-enterovirus-71-infection-in-chinese-children
#16
Na Zhao, Hui-Lan Chen, Zhen-Zhen Chen, Jing Li, Zong-Bo Chen
BACKGROUND: Enterovirus 71 (EV71) infection results in some severe complications with high mortality and disability in Hand, Foot and Mouth Disease (HFMD) in children. Recent studies have shown that cytokine genetic predispositions have associations with both the development of EV71 infection and severity of HFMD. OBJECTIVE: This study was designed to investigate whether the IL-10-592 polymorphism is associated with IL-10 levels and disease severity in Chinese children with EV71 infection...
August 19, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28838035/spatiotemporal-variation-of-hand-foot-mouth-disease-in-relation-to-socioecological-factors-a-multiple-province-analysis-in-vietnam
#17
Dung Phung, Huong Xuan Nguyen, Huong Lien Thi Nguyen, Cuong Manh Do, Quang Dai Tran, Cordia Chu
BACKGROUND: Hand-foot-and-mouth disease (HFMD) is a significant public health issue in Asia-pacific countries. Numerous studies have examined the relationship between socio-ecological factors and HFMD however the research findings were inconsistent. This study examined the association between socio-ecologic factors and HFMD in multiple provinces across Vietnam. METHODS: We applied a spatial autoregressive model using a Bayesian framework to examine the relationship between HFMD and socio-demographic factors...
August 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28835799/discovery-of-potent-ev71-capsid-inhibitors-for-treatment-of-hfmd
#18
Peng Li, Jun Yu, Fei Hao, Haiying He, Xuyang Shi, Jiao Hu, Li Wang, Chunyan Du, Xiao Zhang, Ya Sun, Fusen Lin, Zhengxian Gu, Deming Xu, Xinsheng Chen, Liang Shen, Guoping Hu, Jian Li, Shuhui Chen, Wei Xiao, Zhenzhong Wang, Qingming Guo, Xiujuan Chang, Xuyang Tian, Tianwei Lin
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiviral efficacy because its occupancy by suitable compounds could stabilize the virus capsid, thus preventing uncoating of virus for RNA release. In this Letter, design, synthesis, and biological evaluation of novel anti-EV71 agents (aminopyridyl 1,2,5-thiadiazolidine 1,1-dioxides) are described...
August 10, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28832767/antiviral-activity-of-shikonin-ester-derivative-pmm-034-against-enterovirus-71-in-vitro
#19
Y Zhang, H Han, L Sun, H Qiu, H Lin, L Yu, W Zhu, J Qi, R Yang, Y Pang, X Wang, G Lu, Y Yang
Human enterovirus 71 (EV71) is the major causative agent of hand, foot, and mouth disease (HFMD), particularly in infants and children below 4 years of age. Shikonin is a bioactive compound with anti-inflammatory, antiviral, and antibacterial activities derived from the roots of the Chinese medicinal herb Lithospermum erythrorhizon. This study aimed to examine the antiviral activity of PMM-034, a shikonin ester derivative, against EV71 in rhabdomyosarcoma (RD) cells. Cytotoxicity of PMM-034 on RD cells was determined using WST-1 assay...
August 17, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28828580/formulation-and-in-vitro-release-kinetics-of-mucoadhesive-blend-gels-containing-matrine-for-buccal-administration
#20
Xiaojin Chen, Jun Yan, Shuying Yu, Pingping Wang
Enterovirus 71 (EV71) is a pathogenic factor of severe hand, foot, and mouth disease (HFMD). No vaccine or specific treatment is currently available for EV71 infection. Hence, we developed a buccal mucoadhesive gel containing matrine to protect against HFMD. Mucoadhesive gels were prepared by Carbopol 974P and were combined with Carbopol 971P, sodium carboxymethyl cellulose (CMC-Na), or hydroxypropylmethy cellulose (HPMC K100M). The formulations were characterized in terms of tensile testing and continuous flow techniques for mucoadhesion...
August 21, 2017: AAPS PharmSciTech
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