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Hand foot and mouth disease

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https://www.readbyqxmd.com/read/28508043/crystal-structure-of-2c-helicase-from-enterovirus-71
#1
Hongxin Guan, Juan Tian, Bo Qin, Justyna Aleksandra Wojdyla, Bei Wang, Zhendong Zhao, Meitian Wang, Sheng Cui
Enterovirus 71 (EV71) is the major pathogen responsible for outbreaks of hand, foot, and mouth disease. EV71 nonstructural protein 2C participates in many critical events throughout the virus life cycle; however, its precise role is not fully understood. Lack of a high-resolution structure made it difficult to elucidate 2C activity and prevented inhibitor development. We report the 2.5 Å-resolution crystal structure of the soluble part of EV71 2C, containing an adenosine triphosphatase (ATPase) domain, a cysteine-rich zinc finger with an unusual fold, and a carboxyl-terminal helical domain...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28506791/enterovirus-71-induced-has-mir-21-contributes-to-evasion-of-host-immune-system-by-targeting-myd88-and-irak1
#2
Na Feng, Zhizhao Zhou, Yuanxia Li, Lifang Zhao, Zhengfeng Xue, Rong Lu, Kunpeng Jia
Enterovirus71(EV71), the etiological agent of hand-foot-and-mouth disease, has increasingly become a public health challenge around the world. Type I interferons (IFNs) are an important family of cytokines that regulate innate and adaptive immune responses to pathogens.These pathways are tightly regulated by the host to prevent an inappropriate cellular response, but viruses can modulate these pathways to proliferate and spread. In this study, we demonstrated that EV71 evades the immune surveillance system to proliferate by activating microRNA-21...
May 12, 2017: Virus Research
https://www.readbyqxmd.com/read/28498983/atypical-hand-foot-and-mouth-disease-due-to-coxsackievirus-a6-in-a-traveler-returning-from-indonesia-to-italy
#3
Donata Magnelli, Lorenzo Zammarchi, Alberto Antonelli, Francesco Martelli, Gian Maria Rossolini, Alessandro Bartoloni
No abstract text is available yet for this article.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28495768/complete-genome-sequence-of-an-enterovirus-71-strain-isolated-from-the-cerebrospinal-fluid-of-a-child-with-severe-hand-foot-and-mouth-disease-in-yunnan-china-2013
#4
Keqin Lin, Haihao Zhang, Wei Bai, Yiling Zhao, Hongbo Liu, Xiaoqin Huang, Zhaoqing Yang, Shaohui Ma
The complete genome sequence of the enterovirus 71 strain CSF15/YN/CHN/2013, first isolated from cerebrospinal fluid of a child in Yunnan, China, in 2013, was determined. According to the phylogenetic and homogeneity analyses, the isolate was assigned to subgenotype C4a.
May 11, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28489032/clinical-significance-and-prognostic-effect-of-serum-25-hydroxyvitamin-d-concentrations-in-critical-and-severe-hand-foot-and-mouth-disease
#5
Hong-Xing Dang, Cheng-Jun Liu, Jing Li, Shi-Jiao Chen, Feng Xu
OBJECTIVE: To examine the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with critical and severe hand, foot and mouth disease (HFMD) and assess the clinical significance and prognostic effect of 25(OH)D concentrations in children with HFMD. METHODS: This is a prospective observational study. The 138 children with HFMD were divided into common (49 cases), severe (52 cases), and critical (37 cases) HFMD groups. Another 59 healthy children undergoing outpatient medical examinations during the same period were chosen as the control group...
May 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28486500/epidemiological-and-aetiological-characteristics-of-hand-foot-and-mouth-disease-in-shijiazhuang-city-hebei-province-china-2009-2012
#6
Huifang Tian, Yong Zhang, Yan Shi, Xiujuan Li, Qiang Sun, Li Liu, Dong Zhao, Baohong Xu
Large outbreaks of hand, foot, and mouth disease (HFMD) have repeatedly occurred in mainland of China since 2007. In this study, we investigated the epidemiological and aetiological characteristics of HFMD in Shijiazhuang City, one of the biggest northern cities of China. A total of 57,173 clinical HFMD cases, including 911 severe and 32 fatal cases, were reported in Shijiazhuang City during 2009-2012. The disease incidence peaked during March-July, with a small increase in the number of cases observed in November of each year...
2017: PloS One
https://www.readbyqxmd.com/read/28482808/valine-isoleucine-variants-drive-selective-pressure-in-the-vp1-sequence-of-ev-a71-enteroviruses
#7
Nghia Ngu Duy, Le Thi Thanh Huong, Patrice Ravel, Le Thi Song Huong, Ankit Dwivedi, October Michael Sessions, Yan'An Hou, Robert Chua, Guilhem Kister, Aneta Afelt, Catherine Moulia, Duane J Gubler, Vu Dinh Thiem, Nguyen Thi Hien Thanh, Christian Devaux, Tran Nhu Duong, Nguyen Tran Hien, Emmanuel Cornillot, Laurent Gavotte, Roger Frutos
BACKGROUND: In 2011-2012, Northern Vietnam experienced its first large scale hand foot and mouth disease (HFMD) epidemic. In 2011, a major HFMD epidemic was also reported in South Vietnam with fatal cases. This 2011-2012 outbreak was the first one to occur in North Vietnam providing grounds to study the etiology, origin and dynamic of the disease. We report here the analysis of the VP1 gene of strains isolated throughout North Vietnam during the 2011-2012 outbreak and before. METHODS: The VP1 gene of 106 EV-A71 isolates from North Vietnam and 2 from Central Vietnam were sequenced...
May 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28482389/-observation-on-intestinal-viral-shedding-time-of-hand-foot-and-mouth-disease-induced-by-coxsackievirus-a6
#8
S Y Zhao, J Wang, S Teng, J Zhou, X Y Lin, W Song, Y D Wu, Y Wei
Objective: To observe the intestinal viral shedding time in patients with hand, food and mouth disease (HFMD) induced by coxsackievirus A6 (CA6). Method: Throat swab specimens and stool specimens of HFMD children were collected from those admitted to Hangzhou Children's Hospital between May and October 2015, while fluorescence quantitative PCR was used to detect the viral load.Eeighteen cases of HFMD children were followed up, who were confirmed as CA6 infection via laboratory tests.Stool specimen was collected every 4-7 days, and fluorescence PCR was used for virus nucleic acid detection until the stool viral nucleic acids of infected children turned to be negative...
May 4, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28480969/epidemiological-and-genetic-analysis-concerning-the-non-enterovirus-71-and-non-coxsackievirus-a16-causative-agents-related-to-hand-foot-and-mouth-disease-in-anyang-city-henan-province-china-from-2011-to-2015
#9
Yang Li, Honghong Bao, Xiangping Zhang, Mingqiang Zhai, Xiaobing Bao, Demin Wang, Shuanhu Zhang
Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) are major pathogens of hand, foot and mouth disease (HFMD) and have been associated with consecutive outbreaks of HFMD in China over the past years. Although several other human enteroviruses (HEVs) have also acted as causative agents of HFMD, published information on their roles in the prevalence of HFMD is limited. This study was conducted to reveal the characteristics of the pathogenic spectrum and molecular epidemiology of the non-EV-71 and non-CV-A16 HEVs in Anyang City, which is located in north-central China and has a population of 5 million...
May 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28468063/-health-related-quality-of-life-on-severe-hand-foot-and-mouth-disease-patients
#10
Y M Zheng, J Yang, Q H Liao
Objective: To evaluate the health related quality of life (HRQoL) for severe hand, foot and mouth disease (HFMD) patients with different complications. Methods: A national telephone interview under the EQ-5D proxy2 questionnaire (EQ-SD and EQ-VAS), was conducted to obtain the HRQoL of lab-confirmed severe HFMD patients, aged between six months and five-year-olds from the national communicable disease surveillance system from January 1, 2012 to December 31, 2013. Results: A total of 685 severe HFMD cases were included in the study...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28468059/-hand-foot-and-mouth-disease-in-hubei-province-2009-2015-an-epidemiological-and-etiological-study
#11
Q Chen, X S Xing, Y Wu, Q H Liao, G P Liu, X Q Jiang, X H Guan
Objective: To clarify the age patterns and types of differences so as to provide reference on prevention and interventions of hand, foot and mouth disease (HFMD) cases, in Hubei province. Methods: We collected the HFMD case information of Hubei province from the Chinese National Notifiable Infectious Disease Reporting System in 2009-2015 while the information on pathogens from the laboratory monitoring system of Center for Disease Control and Prevention at all levels in Hubei province. All the data were stratified by age, disease severity, laboratory confirmation status, and serotypes of enterovirus...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28466042/serosurveillance-of-foot-and-mouth-disease-in-karnataka-state-india-a-3%C3%A2-years-study
#12
Raveendra Hegde, Srikanth Kowalli, K Nagaraja, N K Dharanesha, C M Seema, Tanveer Ahmed Khan, G V Nagaraj, K Srikala, K J Sudharshana, D Nagaraju, Shesha Rao, P Giridhara, S M Byregowda
A prospective serological investigation was conducted to determine the prevalence and distribution of foot-and-mouth disease (FMD), as well as to monitor the effectiveness of the FMD control programme (FMD-CP) through vaccination in Karnataka, India. Random serum samples were collected every year between May and August before the start of vaccination in 2011, and subsequently following two phases of vaccination in 2012 and 2013. Infection status (seroprevalence) was inferred by subjecting the sera to indirect r3AB3 non-structural protein-ELISA, using kits developed by the Project Directorate on FMD, India...
September 2016: Virusdisease
https://www.readbyqxmd.com/read/28463891/neuro-magnetic-resonance-imaging-in-hand-foot-and-mouth-disease-finding-in-412-patients-and-prognostic-features
#13
Zhou-Yang Lian, He-Hong Li, Bin Zhang, Yu-Hao Dong, Wu-Xu Deng, Jing Liu, Xiao-Ning Luo, Biao Huang, Chang-Hong Liang, Shui-Xing Zhang
PURPOSE: The aims of this study were to describe the neuroimaging findings in hand, foot, and mouth disease and determine those who may provide prognosis. MATERIAL AND METHODS: Magnetic resonance imaging scans in 412 severe hand, foot, and mouth disease between 2009 and 2014 were retrospectively evaluated. The patients who had the neurological signs were followed for 6 months to 1 year. According to the good or poor prognosis, 2 groups were categorized. The incidence of lesions in different sites between the 2 groups was compared, and multivariate analysis was used to look for risk factors...
April 21, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28461310/structure-of-ev71-3c-pro-in-complex-with-nk-1-8k-indications-for-the-development-of-anti-enterovirus-protease-inhibitor
#14
Yaxin Wang, Lin Cao, Yangyang Zhai, Zheng Yin, Yuna Sun, Luqing Shang
Hand-foot-and-mouth disease (HFMD) caused by enterovirus is a threat to public health in worldwide. Up-to-date, enterovirus 71 (EV71) becomes one of the major causative agents of HFMD in Pacific-Asia region and causes millions of infections from its outbreak. However, no drug is currently available for clinical therapeutics. In our previous works, we developed a set of protease inhibitors (PIs) targeting EV71 3C(pro), among which NK-1.8k and NK-1.9k with various active group have high potency and selectivity...
May 1, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28447721/clinical-significance-of-inflammatory-cytokine-and-chemokine-expression-in-hand-foot-and-mouth-disease
#15
Ping Shao, Xiaoxin Wu, Hongbo Li, Zhigang Wu, Zongxin Yang, Hangping Yao
The present study examined the relationship between cytokine and chemokine expression and the clinical presentation of hand, foot and mouth disease (HFMD), which is currently unclear. The present study involved 28 patients with mild HFMD, 44 patients with severe HFMD and 26 healthy children. Venous blood was tested for cytokine [interleukin (IL)‑4, IL‑12, IL‑18, tumor necrosis factor‑α (TNF‑α), interferon‑γ (IFN‑γ)] and chemokine expression [IL‑8, regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein‑1 (MCP‑1) and IFN-γ-inducible protein‑10 (IP‑10)]...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447294/the-binding-of-a-monoclonal-antibody-to-the-apical-region-of-scarb2-blocks-ev71-infection
#16
Xuyuan Zhang, Pan Yang, Nan Wang, Jialong Zhang, Jingyun Li, Hao Guo, Xiangyun Yin, Zihe Rao, Xiangxi Wang, Liguo Zhang
Entero virus 71 (EV71) causes hand, foot, and mouth disease (HFMD) and occasionally leads to severe neurological complications and even death. Scavenger receptor class B member 2 (SCARB2) is a functional receptor for EV71, that mediates viral attachment, internalization, and uncoating. However, the exact binding site of EV71 on SCARB2 is unknown. In this study, we generated a monoclonal antibody (mAb) that binds to human but not mouse SCARB2. It is named JL2, and it can effectively inhibit EV71 infection of target cells...
April 26, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28445307/alteration-of-serum-high-mobility-group-protein-1-hmgb1-levels-in-children-with-enterovirus-71-induced-hand-foot-and-mouth-disease
#17
Weikun Zheng, Haifan Shi, Yiping Chen, Zhiwei Xu, Jie Chen, Longteng Jin
Hand, foot, and mouth disease (HFMD) is a common pediatric disease caused by enterovirus infection. It typically presents as a fever along with flat, discolored spots and bumps on the hands, feet, and mouth. Compared with other viruses, enterovirus 71 (EV71)-induced HFMD is more prone to cause severe complications in children, such as brainstem encephalitis, cardiopulmonary disorders, and even death. More in-depth studies are still necessary to understand the characteristics of EV71-induced HFMD, although some related research has been reported so far...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444539/association-of-the-oas3-rs1859330-g-a-genetic-polymorphism-with-severity-of-enterovirus-71-infection-in-chinese-han-children
#18
Yuxia Tan, Tingting Yang, Peipei Liu, Liping Chen, Qingwu Tian, Ya Guo, Hongfang He, Yedan Liu, Zongbo Chen
The 2'5'-oligoadenylate synthetase (OAS) is an interferon (IFN)-induced protein that plays an important role in the antiviral action of IFN, with OAS3 being one of the four OAS classes (OAS1, OAS2, OAS3, OASL). The effect of OAS on several infectious viral diseases has been reported; however, a study of the effect of OAS3 on enterovirus 71 (EV71) is lacking. The purpose of this study was to evaluate the association of the OAS3 rs1859330 G/A genetic polymorphism with susceptibility and severity of EV71 infection...
April 25, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28442520/development-and-application-of-a-duplex-real-time-rt-pcr-assay-for-simultaneous-detection-of-coxsackievirus-a6-and-coxsackievirus-a10
#19
Peiyan He, Yongxiang Li, Jianyong Luo, Henghui Wang, Yong Yan, Zhongwen Chen
Hand, foot and mouth disease (HFMD) is a serious public health problem. Generally, it is considered that HFMD is mainly caused by enterovirus 71 (EV71) and coxsackievirus A16 (CVA16). Nevertheless, the incidence of HFMD caused by coxsackievirus A6 (CVA6) and coxsackievirus A10 (CVA10) has increased significantly and CVA6 and CVA10 have become major causes of HFMD epidemic. This study develops a duplex real-time reverse transcript polymerase chain reaction (RT-PCR) assay for simultaneous detection of CVA 6 and CVA 10...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28438677/a-prospective-comparative-study-of-severe-neurological-and-uncomplicated-hand-foot-and-mouth-forms-of-paediatric-enterovirus-71-infections
#20
Yoann Crabol, Polidy Pean, Channa Mey, Veasna Duong, Beat Richner, Denis Laurent, Ky Santy, Heng Sothy, Philippe Dussart, Arnaud Tarantola, Philippe Buchy, Paul F Horwood
OBJECTIVES: In this study, we document the clinical characteristics and investigated risk factors for uncomplicated and severe forms of EV-A71 disease in Cambodian children. METHODS: From March to July 2014 inclusive, all patients with suspicion of EV-A71 infection presenting to Kantha Bopha Hospitals in Phnom Penh and Siem Reap and confirmed by the Virology Unit at the Institut Pasteur du Cambodge were prospectively enrolled in this study. Throat swabs, rectal swabs and serum samples were collected from all consecutive patients with suspected EV-A71 infection...
April 22, 2017: International Journal of Infectious Diseases: IJID
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