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Hand foot and mouth disease

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https://www.readbyqxmd.com/read/28100321/-application-of-esmolol-in-severe-hand-foot-and-mouth-disease
#1
Lei Zhu, Bo-Xiang Qi, Dai-Hua Fang, Gong-Jian Qi, Kun Gao, Bao-Li Hu
OBJECTIVE: To study the clinical effect and mechanism of action of esmolol in the treatment of severe hand, foot, and mouth disease (HFMD). METHODS: A prospective randomized controlled trial was performed. A total of 102 children with severe HFMD were enrolled in the study and were randomly divided into conventional treatment and esmolol treatment groups (n=51 each). The children in the conventional treatment group were given conventional treatment according to the guidelines for the diagnosis and treatment of HFMD...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28090592/the-first-genome-sequences-of-human-bocaviruses-from-vietnam
#2
Tran Tan Thanh, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Nguyen To Anh, Ha Manh Tuan, Ho Van Hien, Nguyen Manh Tuong, Trinh Trung Kien, Truong Huu Khanh, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Nguyen Van Vinh Chau, Guy Thwaites, H Rogier van Doorn, Le Van Tan
As part of an ongoing effort to generate complete genome sequences of hand, foot and mouth disease-causing enteroviruses directly from clinical specimens, two complete coding sequences and two partial genomic sequences of human bocavirus 1 (n=3) and 2 (n=1) were co-amplified and sequenced, representing the first genome sequences of human bocaviruses from Vietnam. The sequences may aid future study aiming at understanding the evolution of the pathogen.
November 16, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28077584/2-year-efficacy-immunogenicity-and-safety-of-vigoo-enterovirus-71-vaccine-in-healthy-chinese-children-a-randomized-open-label-study
#3
Mingwei Wei, Fanyue Meng, Shiyuan Wang, Jingxin Li, Yuntao Zhang, Qunying Mao, Yuemei Hu, Pei Liu, Nianmin Shi, Hong Tao, Kai Chu, Yuxiao Wang, Zhenglun Liang, Xiuling Li, Fengcai Zhu
BACKGROUND:  This study evaluated the 2-year efficacy, immunogenicity, and safety of the Vigoo enterovirus 71 (EV71) vaccine. METHOD:  In an initial phase 3 study, we randomly assigned healthy infants and children aged 6-35 months (ratio, 1:1) to receive 2 doses of either EV71 vaccine (5120 participants) or placebo (5125 participants) at days 0 and 28, and followed them for 12 months after vaccination. In this extended follow-up study, we continued to evaluate the efficacy, immunogenicity, and safety of the EV71 vaccine for up to 2 years...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28073399/enterovirus-71-induces-apoptosis-by-directly-modulating-the-conformational-activation-of-pro-apoptotic-protein-bax
#4
Xiaodong Han, Haolong Cong
Enterovirus 71 (EVA71), a virus of the genus enterovirus in the picornaviridae family, is one of the main causative agents of foot, hand and mouth disease in infected infants and young children. In this study, we report that cells with EVA71 infection exhibit increased levels of cytochrome c release and Caspase-3 activation. EVA71 infection induces the conformational activation of pro-apoptotic protein Bax, and the subsequent formation of oligomers of Bax in mitochondria. Inhibitors that block Caspase-8 activation cannot inhibit apoptosis induced by EVA71 infection...
January 10, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28071799/seroepidemiological-and-phylogenetic-characterisation-of-neurotropic-enteroviruses-in-ireland-2005-2014
#5
Jorge Abboud Guerra, Allison Waters, Alison Kelly, Ursula Morley, Paul O'Reilly, Edwin O'Kelly, Jonathan Dean, Robert Cunney, Piaras O'Lorcain, Suzanne Cotter, Jeff Connell, Joanne O'Gorman, William W Hall, Michael Carr, Cillian F De Gascun
Enteroviruses (EVs) are associated with a broad spectrum of clinical presentation, including aseptic meningitis (AM), encephalitis, hand, foot and mouth disease, acute flaccid paralysis and acute flaccid myelitis. Epidemics occur sporadically and are associated with increased cases of AM in children. The present study describes the seroepidemiological analysis of circulating EVs in Ireland from 2005-2014 and phylogenetic characterisation of echovirus 30 (E-30), enterovirus A71 (EV-A71) and enterovirus D68 (EV-D68)...
January 10, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28069250/the-exposure-response-relationship-between-temperature-and-childhood-hand-foot-and-mouth-disease-a-multicity-study-from-mainland-china
#6
Xiong Xiao, Antonio Gasparrini, Jiao Huang, Qiaohong Liao, Fengfeng Liu, Fei Yin, Hongjie Yu, Xiaosong Li
BACKGROUND: Hand, foot and mouth disease (HFMD) is a rising public health issue in the Asia-Pacific region. Numerous studies have tried to quantify the relationship between meteorological variables and HFMD but with inconsistent results, in particular for temperature. We aimed to characterize the relationship between temperature and HFMD in various locations and to investigate the potential heterogeneity. METHODS: We retrieved the daily series of childhood HFMD counts (aged 0-12 years) and meteorological variables for each of 143 cities in mainland China in the period 2009-2014...
January 6, 2017: Environment International
https://www.readbyqxmd.com/read/28063993/inhibition-of-enterovirus-71-replication-by-an-%C3%AE-hydroxy-nitrile-derivative-nk-1-9k
#7
Yaxin Wang, Lin Cao, Yangyang Zhai, Jiaming Ma, Quandeng Nie, Ting Li, Zheng Yin, Yuna Sun, Luqing Shang
Enterovirus 71 (EV71) is one of the major etiological agents of human hand-foot-and-mouth disease (HFMD) worldwide. EV71 infection in young children and people with immunodeficiency causes severe symptoms with a high fatality rates. However, there is still no approved drugs to treat such infections. Based on our previous report of a peptide-aldehyde anti-EV71 protease, we present here a highly specific α-hydroxy-nitrile derivative NK-1.9k, which inhibited the proliferation of multiple EV71 strains and coxsackievirus A16 (CVA16) in various cells with EC50 of 37...
January 4, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28063653/temporal-and-spatial-analysis-of-hand-foot-and-mouth-disease-in-relation-to-climate-factors-a-study-in-the-mekong-delta-region-vietnam
#8
Huong Xuan Nguyen, Cordia Chu, Huong Lien Thi Nguyen, Ha Thanh Nguyen, Cuong Manh Do, Shannon Rutherford, Dung Phung
This study examined the temporal and spatial patterns of hand, foot, and mouth disease (HFMD) in the Mekong Delta region in Vietnam. A time-series analysis was used to examine the temporal patterns of HFMD in relation to climate factors while a retrospective space-time scan was used to detect the high-risk space-time clusters of this disease. A 1°C increase in average temperature was associated with 5.6% increase in HFMD rate at lag 5days (95% CI 0.3-10.9). A 1% increase in humidity had equal influence of 1...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28056277/-direct-medical-costs-and-influencing-factors-in-severe-hand-foot-and-mouth-disease-in-children-aged-between-six-months-and-five-years-old
#9
Y M Zheng, J Yang, Q H Liao
Objective: To estimate the direct medical cost of severe hand, foot and mouth disease (HFMD) in patients aged less than five years. Methods: A stratified sampling method was used to collect data on severe HFMD cases reported in the National HFMD surveillance database between Jan 1, 2012, and Dec 31, 2013. The sampling was referenced with the national aetiologic distribution of Enterovirus A71 (EV-A71), Coxsackievirus A16 (CV-A16) and other Enteroviruses (OEV) for severe HFMD cases and the included cases were distributed among seven geographic regions (Northeast, North China, Northwest, Central China, Southwest, East China and South China)...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28042848/epidemiologic-features-of-enterovirus-71-associated-hand-foot-and-mouth-disease-from-2009-to-2013-in-zhejiang-china
#10
Zhifang Wang, Huakun Lv, Wenming Zhu, Zhe Mo, Guangming Mao, Xiaofeng Wang, Xiaoming Lou, Yongdi Chen
Enterovirus 71 (EV71) usually causes hand-foot-and-mouth disease (HFMD) with severe clinical symptoms and even deaths in China. There is no efficient antiviral drug to protect against severe EV71-associated HFMD, making the development of EV71 vaccines therefore a priority. However, the potential target subject population(s) to be immunized with EV71 vaccine are not well understood. In this study, we characterized the epidemiology regarding EV71-associated HFMD on the basis of provincial-level surveillance...
December 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28030850/changes-of-circulating-th22-cells-in-children-with-hand-foot-and-mouth-disease-caused-by-enterovirus-71-infection
#11
Dawei Cui, Fengyun Zhong, Jie Lin, Yidong Wu, Quan Long, Xianzhi Yang, Qiaoyun Zhu, Li Huang, Qifen Mao, Zhaoxia Huo, Zhe Zhou, Guoliang Xie, Shufa Zheng, Fei Yu, Yu Chen
Interleukin (IL)-22+CD4+T (Th22) cells play crucial roles in the pathogenesis of autoimmune diseases and infectious diseases, although the role of Th22 cells remains largely unclear in children with hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71). This study aims to explore the role of circulating IL-22+IL-17A-CD4+T (cTh22) cells in children with EV71-associated HFMD. We found that during the acute stage of illness, the frequencies of cTh22 and circulating IL-22+IL-17A+CD4+T (IL-22+cTh17) cells in CD4+T cells infrom affected patients, and especially in severely affected patients, were significantly higher than in healthy controls (HC)...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28030650/two-genotypes-of-coxsackievirus-a2-associated-with-hand-foot-and-mouth-disease-circulating-in-china-since-2008
#12
Qian Yang, Yong Zhang, Dongmei Yan, Shuangli Zhu, Dongyan Wang, Tianjiao Ji, Xiaolei Li, Yang Song, Xinrui Gu, Wenbo Xu
Coxsackievirus A2 (CV-A2) has been frequently detected and commonly associated with hand, foot, and mouth disease (HFMD) in China since 2008. However, limited sequences of CV-A2 are currently available. As a result, we have been focusing on the genetic characteristics of CV-A2 in the mainland of China during 2008-2015 based on national HFMD surveillance. In this study, 20 CV-A2 strains were isolated and phylogenetic analyses of the VP1 sequences were performed. Full-length genome sequences of two representative CV-A2 isolates were acquired and similarity plot and bootscanning analyses were performed...
2016: PloS One
https://www.readbyqxmd.com/read/28027826/clinicopathologic-analysis-of-atypical-hand-foot-and-mouth-disease-in-adult-patients
#13
Julie Second, Charles Velter, Sophie Calès, François Truchetet, Dan Lipsker, Bernard Cribier
BACKGROUND: Hand, foot, and mouth disease is a contagious viral infection usually affecting children. A resurgence of cases in adults, mainly caused by coxsackievirus A6 and with an atypical and more severe presentation, has taken place. OBJECTIVE: The goal was to examine the clinical, histologic, and immunohistochemical features of this disease in adults. METHODS: This is a retrospective study on documented cases of adult hand, foot, and mouth disease from France's Dermatology Department of Strasbourg University Hospital and Bel-Air Hospital in Thionville...
December 24, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28002358/an-outbreak-of-kingella-kingae-infections-complicating-a-severe-hand-foot-and-mouth-disease-outbreak-in-nice-france-2016
#14
Nawal El Houmami, Virginie Cointat, Audrey Mirand, Virginie Fouilloux, Janek Bzdrenga, Sofiane Bakour, Philippe Minodier, Marie-Amélie Dubois, Francoise Anave-Frapech, Rémi Charrel, Didier Raoult, Pierre-Edouard Fournier
We report the investigative methods for the diagnosis of an epidemic and culture-negative K. kingae endocarditis complicating a severe outbreak of hand, foot, and mouth disease in a childcare center. The diagnosis was confirmed by PCR testings performed from cardiac tissue. Our findings argue for the systematic investigation of K. kingae outbreaks by using molecular tools in such context.
December 19, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27998409/-epidemiologic-features-of-hand-foot-mouth-disease-in-haikou-city-from-2008-to-2015
#15
C Y Lin, M C Wang, X P Zeng, S Z Kuang, X B Lin
Objective: To analyze the epidemiologic features of hand-foot-mouth disease (HFMD) in Haikou city from 2008 to 2015. Methods: Descriptive methods on epidemiology and detection on pathogens were conducted in Haikou city from 2008 to 2015. Results: A total of 71 611 patients were diagnosed as HFMD in Haikou city from 2008 to 2015, including 728 severe cases, accounting for 1.02% among all the cases. The average annual incidence was 458.89/100 000. A total of 11 deaths were caused by the disease, with the average annual mortality rate as 0...
December 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27998408/-surveillance-on-the-epidemiological-and-etiological-characteristics-of-hand-foot-mouth-disease-during-the-outbreaks-in-three-cities-of-jiangsu-province-2012-2015
#16
H Fan, Y S Fu, J Shan, C Shi, X F Zhang, X Huo, C J Bao, H Ji
Objective: To analyze the epidemiological and etiological characteristics through monitoring the outbreaks of hand-foot-mouth disease (HFMD), in three cities of Jiangsu province from 2012 to 2015 and to provide evidence for prevention and control of the disease. Methods: Data related to cases of HFMD during the outbreaks was collected through active surveillance programs in three cities of Jiangsu province, under the guidelines of clusters and outbreaks of HFMD (2012 edition HFMD). Features related to clusters and outbreaks of the disease were identified according to the real-time RT-PCR detection...
December 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27990387/late-onset-acute-graft-versus-host-disease-mimicking-hand-foot-and-mouth-disease
#17
Gauri Mahabal, Leni George, Mandeep Bindra, Biju George
Acute skin graft-versus-host disease (GVHD) classically presents as a pruritic erythematous maculopapular rash. We describe a patient who underwent allogeneic hematopoietic stem cell transplantation and presented with a hand foot and mouth disease like clinical presentation. Histopathology was suggestive of acute GVHD. This case is being reported to make dermatologists aware of this unusual presentation of GVHD.
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27974562/in-vivo-imaging-with-bioluminescent-enterovirus-71-allows-for-real-time-visualization-of-tissue-tropism-and-viral-spread
#18
Elizabeth A Caine, Jorge E Osorio
: Hand, foot, and mouth disease (HFMD) is a re-emerging illness caused by a variety of enteroviruses. The main causative agents are enterovirus 71 (EV71), Coxsackievirus A16 (CVA16), and most recently Coxsackievirus A6 (CVA6). Infections of enteroviruses can vary from asymptomatic, mild fever and blisters on infected individual's hands, feet, and throat, to severe neurological complications. Viral persistence has also been documented for weeks post infection (w.p.i.) by demonstration of virus in the stool of children...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27943150/hand-foot-and-mouth-disease-like-illness-in-office-practice
#19
N Ganga
OBJECTIVE: To describe the clinical profile of Hand Foot and Mouth Disease (HFMD) like illness in a cluster of cases. METHODS: Children presenting with papulovesicular skin lesions with or without oral lesions were clinically examined, treated and followed up. RESULTS: Out of 21 cases, 18 (85.7%) were less than 3y and 15 (71.4%) were males. Skin lesions were seen in 100% with predominant involvement of dorsum of hands, feet, palms and soles...
December 12, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27941929/characterization-of-enterovirus-71-infection-and-associated-outbreak-of-hand-foot-and-mouth-disease-in-shawo-of-china-in-2012
#20
Michelle Y Liu, Jin Liu, Weijian Lai, Jun Luo, Yingle Liu, Gia-Phong Vu, Zhu Yang, Phong Trang, Hongjian Li, Jianguo Wu
Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment and prevention of the associated HFMD outbreaks. In this report, we studied an outbreak of 105 HFMD cases in Shawo Township of China between September to October 2012. More than 90% of cases were children younger than 9 years old, with over 50% of cases aged 3-6 years old...
December 12, 2016: Scientific Reports
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