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Enterovirus 71

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https://www.readbyqxmd.com/read/29042981/sophocarpine-against-enterovirus-71-in-vitro
#1
Zengjun Jin, Lixin Yang, Guotao Ding, Guoxing Yang, Yonghong Han, Xia Zhang, Weihao Li
Sophocarpine (SCA) is a bioactive alkaloid present in Sophoraflavescens Ait. The present study demonstrated that SCA inhibited enterovirus 71 (EV71) infection in Vero cells. The results indicated that the 50% cytotoxicity concentration of SCA for Vero cells was 1,346 µg/ml, and the 50% inhibition concentration of SCA against EV71 was 350 µg/ml. SCA produced a marked inhibitory effect against EV71 when the Vero cells were treated with SCA prior to infection with the virus. Additionally, SCA was effective against EV71 when the Vero cells were infected with EV71 (100xTCID50) that had been treated with SCA for 2 h, and was effective when the Vero cells were infected with EV71 (100xTCID50) at 37°C under 5% CO2 for 2 h prior to treatment with SCA for 2 h...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29039066/pattern-classification-of-enterovirus-71-associated-hand-foot-and-mouth-disease-in-chinese-medicine-a-retrospective-study-in-433-cases
#2
Yan Liu, Li-Yun He, Tian-Cai Wen, Shi-Yan Yan, Wen-Jing Bai, Bao-Yan Liu
OBJECTIVE: To determine whether patterns of enterovirus 71 (EV71)-associated hand, foot, and mouth disease (HFMD) were classified based on symptoms and signs, and explore whether individual characteristics were correlated with membership in particular pattern. METHODS: Symptom-based latent class analysis (LCA) was used to determine whether patterns of EV71-HFMD existed in a sample of 433 cases from a clinical data warehouse system. Logistic regression was then performed to explore whether demographic, and laboratory data were associated with pattern membership...
October 17, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29037172/the-impact-of-influenza-on-the-health-related-quality-of-life-in-china-an-eq-5d-survey
#3
Juan Yang, Mark Jit, Yaming Zheng, Luzhao Feng, Xinxin Liu, Joseph T Wu, Hongjie Yu
BACKGROUND: Influenza causes considerable morbidity and mortality in China, but its impact on the health-related quality of life (HRQoL) has not been previously measured. METHODS: We conducted a retrospective telephone survey to assess the impact of influenza on the HRQoL among outpatients and inpatients using the EuroQoL EQ-5D-3 L instrument. Participants were individuals with laboratory-confirmed influenza infection registered by the National Influenza-like-illness Surveillance Network in 2013...
October 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29034730/corydaline-inhibits-enterovirus-71-replication-by-regulating-cox-2-expression
#4
Hui-Qiang Wang, Jin Hu, Hai-Yan Yan, Shuo Wu, Yu-Huan Li
Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro...
October 15, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29024766/protective-effect-of-an-alpha-7-nicotinic-acetylcholine-receptor-agonist-against-enterovirus-71-infection-in-neuronal-cells
#5
FengXia Song, LinQin Zhao, RuNan Zhu, QinWei Song, Jie Deng, Run Tian, Fang Wang, Yuan Qian
Enterovirus 71, as one of the dominant pathogens associated with severe hand, foot, and mouth disease, has been well reported to trigger severe neurological symptoms among young children over the last decade, particularly among children in the Asia-Pacific region. To date, no effective antiviral agent has been developed for the treatment of severe enterovirus 71 infection. PNU-282987, a selective alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonist, has been reported to have a neuroprotective effect by participating in inflammatory regulation in previous studies...
October 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29016136/specific-unbinding-forces-between-mutated-human-p-selectin-glycoprotein-ligand-1-and-viral-protein-1-measured-using-force-spectroscopy
#6
Chen-Chu Wang, Kundan Sivashanmugan, Chung-Ku Chen, Jian-Ren Hong, Wei-I Sung, Jiunn-Der Liao, Yuh-Shyong Yang
Protein tyrosine sulfation (PTS) is a key modulator of extracellular protein-protein interaction (PPI), which regulates principal biological processes. For example, the capsid protein VP1 of enterovirus 71 (EV71) specifically interacts with sulfated P-selectin glycoprotein ligand-1 (PSGL-1) to facilitate virus invasion. Currently available methods cannot be used to directly observe PTS-induced PPI. In this study, atomic force microscopy was used to measure the interaction between sulfated or mutated PSGL-1 and VP1...
October 13, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28993196/long-non-coding-rna-expression-profiles-in-different-severity-ev71-infected-hand-foot-and-mouth-disease-patients
#7
Jun Meng, Zhenyu Yao, Yaqing He, Renli Zhang, Hong Yang, Xiangjie Yao, Long Chen, Hailong Zhang, Jinquan Cheng
Enterovirus 71 (EV71) is associated with the severe hand foot and mouth disease (HFMD) outcomes, however the host-virus interaction mechanism and the pathogenesis remain poorly understood. Long non-coding RNAs (lncRNAs) are involved in variety physiological and pathological processes, but the functions of lncRNAs in EV71 infection remain elusive. Here we profiled the expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) from EV71-infected mild patients, severe patients as well as the healthy controls, and identified 8541 lncRNAs were differentially expressed...
October 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28987950/antiviral-activity-of-a-polysaccharide-from-laminaria-japonica-against-enterovirus-71
#8
Yingying Yue, Zhihui Li, Peng Li, Nannan Song, Bingqing Li, Wei Lin, Shuntao Liu
This in vitro study investigated the antiviral activity of an acidic polysaccharide from Laminaria japonica against enterovirus 71 (EV71) as well as its mechanism of action. The LJ04 polysaccharide was purified from Laminaria japonica by affinity chromatography. To investigate its antiviral activity, an MTT assay, q-PCR, immunofluorescent staining and western-blot analysis were performed. To define its mechanism of action, ELISA, q-PCR and flow cytometry were conducted. LJ04 had a low EC50, high CC50 and high SI...
October 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28985237/enterovirus-71-protease-2apro-and-3cpro-differentially-inhibit-the-cellular-endoplasmic-reticulum-associated-degradation-erad-pathway-via-distinct-mechanisms-and-enterovirus-71-hijacks-erad-component-p97-to-promote-its-replication
#9
Tao Wang, Bei Wang, He Huang, Chongyang Zhang, Yuanmei Zhu, Bin Pei, Chaofei Cheng, Lei Sun, Jianwei Wang, Qi Jin, Zhendong Zhao
Endoplasmic reticulum-associated degradation (ERAD) is an important function for cellular homeostasis. The mechanism of how picornavirus infection interferes with ERAD remains unclear. In this study, we demonstrated that enterovirus 71 (EV71) infection significantly inhibits cellular ERAD by targeting multiple key ERAD molecules with its proteases 2Apro and 3Cpro using different mechanisms. Ubc6e was identified as the key E2 ubiquitin-conjugating enzyme in EV71 disturbed ERAD. EV71 3Cpro cleaves Ubc6e at Q219G, Q260S, and Q273G...
October 6, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28979010/hand-foot-and-mouth-disease-in-west-bengal-india-a-preliminary-report-on-clinicovirological-trend-over-3-successive-years-2013-2015
#10
Nilendu Sarma, Sayantani Chakraborty, Abira Dutta, Provash Chandra Sadhukhan
INTRODUCTION: Hand, foot, and mouth disease (HFMD), an enteroviral disease has emerged as a major emerging infection in India. This is caused most commonly by enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) but can also be due to CVA4-10, CVA24, CVB2-5, and echovirus 18 (Echo18). Virological analysis of the cases of HFMD has been infrequently done in India. West Bengal is one of the worst affected states in India. OBJECTIVE: To document the clinical and etiological aspect, the changing patterns and clinic-virological correlation...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28975137/rapid-resolution-of-enterovirus-71-associated-opsoclonus-myoclonus-syndrome-on-intravenous-immunoglobulin
#11
Ahmed Sahly, Laurence Gauquelin, Guillaume Sébire
Nonparaneoplastic opsoclonus-myoclonus ataxia syndrome is a rare neuroinflammatory condition featured by opsoclonus, myoclonus, ataxia, and cognitive behavioral disturbance. The authors report an observation of enterovirus 71-associated opsoclonus-myoclonus ataxia syndrome evolving toward full recovery on intravenous intravenous immunoglobulin (IG) treatment. Based on this case report, enterovirus 71 should be added to the list of infectious agents likely involved in opsoclonus-myoclonus ataxia syndrome, including the emerging subgroup of opsoclonus-myoclonus ataxia syndrome recovering without aggressive or prolonged immunosuppressive intervention...
January 2017: Child neurology open
https://www.readbyqxmd.com/read/28970483/epitope-associated-and-specificity-focused-features-of-ev71-neutralizing-antibody-repertoires-from-plasmablasts-of-infected-children
#12
Kuan-Ying Arthur Huang, Mei-Feng Chen, Yhu-Chering Huang, Shin-Ru Shih, Cheng-Hsun Chiu, Jainn-Jim Lin, Jen-Ren Wang, Kuo-Chien Tsao, Tzou-Yien Lin
Protective antibody levels are critical for protection from severe enterovirus 71 infection. However, little is known about the specificities and functional properties of the enterovirus 71-specific antibodies induced by natural infection in humans. Here we characterize 191 plasmablast-derived monoclonal antibodies from three enterovirus 71-infected children, each of whom shows a distinct serological response. Of the 84 enterovirus 71-specific antibodies, neutralizing antibodies that target the rims and floor of the capsid canyon exhibit broad and potent activities at the nanogram level against viruses isolated in 1998-2016...
October 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28954889/herp-binds-tbk1-to-activate-innate-immunity-and-repress-virus-replication-in-response-to-endoplasmic-reticulum-stress
#13
Maolin Ge, Zhen Luo, Zhi Qiao, Yao Zhou, Xin Cheng, Qibin Geng, Yanyan Cai, Pin Wan, Ying Xiong, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu
Host innate immunity is crucial for cellular responses against viral infection sensed by distinct pattern recognition receptors and endoplasmic reticulum (ER) stress. Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and neurological diseases. However, the exact mechanism underlying the link between ER stress induced by EV71 infection and host innate immunity is largely unknown. In this study, we demonstrated that EV71 infection induces the homocysteine-induced ER protein (HERP), a modulator of the ER stress response which is dependent on the participation of MAVS...
September 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28947773/anti-enterovirus-71-activities-of-melissa-officinalis-extract-and-its-biologically-active-constituent-rosmarinic-acid
#14
Sin-Guang Chen, Yann-Lii Leu, Mei-Ling Cheng, Siew Chin Ting, Ching-Chuan Liu, Shulhn-Der Wang, Cheng-Hung Yang, Cheng-Yu Hung, Hiroaki Sakurai, Kuan-Hsing Chen, Hung-Yao Ho
Enterovirus 71 (EV71) infection is endemic in the Asia-Pacific region. No specific antiviral drug has been available to treat EV71 infection. Melissa officinalis (MO) is a medicinal plant with long history of usage in the European and Middle East. We investigated whether an aqueous solution of concentrated methanolic extract (MOM) possesses antiviral activity. MOM inhibited plaque formation, cytopathic effect, and viral protein synthesis in EV71-infected cells. Using spectral techniques, we identified rosmarinic acid (RA) as a biologically active constituent of MOM...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28938017/a-highly-conserved-amino-acid-in-vp1-regulates-maturation-of-enterovirus-71
#15
Yong-Xin Zhang, Yu-Ming Huang, Quan-Jie Li, Xiao-Yu Li, Yong-Dong Zhou, Fei Guo, Jin-Ming Zhou, Shan Cen
Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in children, causing severe clinical outcomes and even death. Here, we report an important role of the highly conserved alanine residue at position 107 in the capsid protein VP1 (VP1A107) in the efficient replication of EV71. Substitutional mutations of VP1A107 significantly diminish viral growth kinetics without significant effect on viral entry, expression of viral genes and viral production. The results of mechanistic studies reveal that VP1A107 regulates the efficient cleavage of the VP0 precursor during EV71 assembly, which is required, in the next round of infection, for the transformation of the mature virion (160S) into an intermediate or A-particle (135S), a key step of virus uncoating...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28932658/the-process-of-wrapping-virus-revealed-by-a-force-tracing-technique-and-simulations
#16
Yangang Pan, Fuxian Zhang, Liuyang Zhang, Shuheng Liu, Mingjun Cai, Yuping Shan, Xianqiao Wang, Hanzhong Wang, Hongda Wang
Viral entry into the host cell is the first step of virus infection; however, its dynamic process via endocytosis remains largely elusive. Here, the force tracing technique and single particle simulation are combined to investigate the invagination of single human enterovirus 71 (HEV71, a positive single-stranded RNA virus that is associated with hand, foot, and mouth disease) via cell membranes during its host cell entry. The experimental results reveal that the HEV71 invaginates in membrane vesicles at a force of 58 ± 16 pN, a duration time of 278 ± 68 ms...
September 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28900642/a-mutation-resistant-deoxyribozyme-or-gate-for-highly-selective-detection-of-viral-nucleic-acids
#17
Ola Kamar, Sin-Cih Sun, Chieh-Hua Lin, Wan-Yu Chung, Min-Shi Lee, Yu-Chieh Liao, Dmitry M Kolpashchikov, Min-Chieh Chuang
Highly selective probes hybridize only to fully complementary DNA or RNA sequences and, therefore, often fail to recognize mutated viral genomes. Here we designed a probe that possesses two seemingly incompatible properties: it tolerates some point mutations in genome, while it remains selective towards others. An OR deoxyribozyme logic gate was designed to fluorescently report the sequences of enterovirus 71 (EV71) covering ∼90% of all known EV71 strains. Importantly, sequences of closely related coxsackieviruses that differed by single nucleotides were reliably differentiated in 7 out of 8 cases...
September 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28892475/cost-effectiveness-of-a-national-enterovirus-71-vaccination-program-in-china
#18
Wenjun Wang, Jianwen Song, Jingjing Wang, Yaping Li, Huiling Deng, Mei Li, Ning Gao, Song Zhai, Shuangsuo Dang, Xin Zhang, Xiaoli Jia
BACKGROUND AND AIMS: Enterovirus 71 (EV71) has caused great morbidity, mortality, and use of health service in children younger than five years in China. Vaccines against EV71 have been proved effective and safe by recent phase 3 trials and are now available in China. The purpose of this study was to evaluate the health impact and cost-effectiveness of a national EV71 vaccination program in China. METHODS: Using Microsoft Excel, a decision model was built to calculate the net clinical and economic outcomes of EV71 vaccination compared with no EV71 vaccination in a birth cohort of 1,000,000 Chinese children followed for five years...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28882666/clinical-features-for-89-deaths-of-hand-foot-and-mouth-disease-in-guangxi-china-2014
#19
Wei Lin, Ying Su, Min Jiang, Jing Liu, Yan-Yan Zhang, Guang-Min Nong
OBJECTIVES: The aim of this study is to summarize the risk factors of severe Hand, foot and mouth disease (HFMD) and explore the clinical characteristics of pulmonary edema (PE) and non-PE in the deceased patients with HFMD. METHODS: We identified 89 HFMD deaths which were separated into the PE group or non-PE group. Next, patients were divided based on their initial admission to hospitals as stage 1, 2, 3, or 4; at this point, their clinical manifestations were compared...
September 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28871120/development-of-a-luciferase-based-biosensor-to-assess-enterovirus-71-3c-protease-activity-in-living-cells
#20
Yuan Zhang, Xianliang Ke, Caishang Zheng, Yan Liu, Li Xie, Zhenhua Zheng, Hanzhong Wang
Enterovirus 71 (EV71) is a major pathogen of hand, foot, and mouth disease (HFMD). To date, no antiviral drug has been approved to treat EV71 infection. Due to the essential role that EV71 3 C protease (3C(pro)) plays in the viral life cycle, it is generally considered as a highly appealing target for antiviral drug development. In this study, we present a transgene-encoded biosensor that can accurately, sensitively and quantitatively report the proteolytic activity of EV71 3C(pro). This biosensor is based on the catalyzed activity of a pro-interleukin (IL)-1β-enterovirus 3C(pro) cleavage site-Gaussia Luciferase (GLuc) fusion protein that we named i-3CS-GLuc...
September 4, 2017: Scientific Reports
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