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Enterovirus 71

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https://www.readbyqxmd.com/read/28101327/hsa-let-7c-5p-augments-enterovirus-71-replication-through-viral-subversion-of-cell-signaling-in-rhabdomyosarcoma-cells
#1
Bingfei Zhou, Min Chu, Shanshan Xu, Xiong Chen, Yongjuan Liu, Zhihao Wang, Fengfeng Zhang, Song Han, Jun Yin, Biwen Peng, Xiaohua He, Wanhong Liu
BACKGROUND: Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for its own replication. However, the roles of microRNAs (miRNAs) in this process remain obscure. RESULTS: In this study, we found that the miRNA hsa-let-7c-5p was significantly upregulated in EV71-infected rhabdomyosarcoma cells. The overexpression of hsa-let-7c-5p promoted replication of the virus, and the hsa-let-7c-5p inhibitor suppressed viral replication...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28100320/-association-of-tlr3-1377c-t-gene-polymorphisms-and-expression-with-susceptibility-to-enterovirus-71-encephalitis-in-children
#2
Ai-Yun Yuan, Hong-Fang He, Fu-Yan Lyu, Pei-Pei Liu, Jing-Fei Hu, Zong-Bo Chen
OBJECTIVE: To investigate the association of gene polymorphisms of Toll-like receptor 3 (TLR3)-1377C/T and expression of TLR3 with the susceptibility to enterovirus 71 (EV71) encephalitis in children. METHODS: A total of 187 children with EV71 infection (59 children in the encephalitis group and 128 in the non-encephalitis group) and 232 children who underwent physical examination were enrolled in the case-control study. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the TLR3-1377C/T gene polymorphisms...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28077584/2-year-efficacy-immunogenicity-and-safety-of-vigoo-enterovirus-71-vaccine-in-healthy-chinese-children-a-randomized-open-label-study
#3
Mingwei Wei, Fanyue Meng, Shiyuan Wang, Jingxin Li, Yuntao Zhang, Qunying Mao, Yuemei Hu, Pei Liu, Nianmin Shi, Hong Tao, Kai Chu, Yuxiao Wang, Zhenglun Liang, Xiuling Li, Fengcai Zhu
BACKGROUND:  This study evaluated the 2-year efficacy, immunogenicity, and safety of the Vigoo enterovirus 71 (EV71) vaccine. METHOD:  In an initial phase 3 study, we randomly assigned healthy infants and children aged 6-35 months (ratio, 1:1) to receive 2 doses of either EV71 vaccine (5120 participants) or placebo (5125 participants) at days 0 and 28, and followed them for 12 months after vaccination. In this extended follow-up study, we continued to evaluate the efficacy, immunogenicity, and safety of the EV71 vaccine for up to 2 years...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28073399/enterovirus-71-induces-apoptosis-by-directly-modulating-the-conformational-activation-of-pro-apoptotic-protein-bax
#4
Xiaodong Han, Haolong Cong
Enterovirus 71 (EVA71), a virus of the genus enterovirus in the picornaviridae family, is one of the main causative agents of foot, hand and mouth disease in infected infants and young children. In this study, we report that cells with EVA71 infection exhibit increased levels of cytochrome c release and Caspase-3 activation. EVA71 infection induces the conformational activation of pro-apoptotic protein Bax, and the subsequent formation of oligomers of Bax in mitochondria. Inhibitors that block Caspase-8 activation cannot inhibit apoptosis induced by EVA71 infection...
January 10, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28063993/inhibition-of-enterovirus-71-replication-by-an-%C3%AE-hydroxy-nitrile-derivative-nk-1-9k
#5
Yaxin Wang, Lin Cao, Yangyang Zhai, Jiaming Ma, Quandeng Nie, Ting Li, Zheng Yin, Yuna Sun, Luqing Shang
Enterovirus 71 (EV71) is one of the major etiological agents of human hand-foot-and-mouth disease (HFMD) worldwide. EV71 infection in young children and people with immunodeficiency causes severe symptoms with a high fatality rates. However, there is still no approved drugs to treat such infections. Based on our previous report of a peptide-aldehyde anti-EV71 protease, we present here a highly specific α-hydroxy-nitrile derivative NK-1.9k, which inhibited the proliferation of multiple EV71 strains and coxsackievirus A16 (CVA16) in various cells with EC50 of 37...
January 4, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28060938/ev71-3d-protein-binds-with-nlrp3-and-enhances-the-assembly-of-inflammasome-complex
#6
Wenbiao Wang, Feng Xiao, Pin Wan, Pan Pan, Yecheng Zhang, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu
Activation of NLRP3 inflammasome is important for effective host defense against invading pathogen. Together with apoptosis-associated speck-like protein containing CARD domain (ASC), NLRP3 induces the cleavage of caspase-1 to facilitate the maturation of interleukin-1beta (IL-1β), an important pro-inflammatory cytokine. IL-1β subsequently plays critical roles in inflammatory responses by activating immune cells and inducing many secondary pro-inflammatory cytokines. Although the role of NLRP3 inflammasome in immune response is well defined, the mechanism underlying its assembly modulated by pathogen infection remains largely unknown...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28053847/evaluation-of-antiviral-activity-of-zanthoxylum-species-against-picornaviruses
#7
Hwa-Jung Choi
Human rhinoviruses and enteroviruses (family Picornaviridae) infect millions of people worldwide each year, but little is known about effective therapeutical treatment for the infection caused by these viruses. We sought to determine whether or not Zanthoxylum (Rutaceae) species can exhibit antiviral activity against picornaviruses. The leaf parts of four Zanthoxylum species were extracted with methanol, and the extracts were investigated for their antiviral activity against picornaviruses using cytopathic effects by cytopathic effect reduction...
December 2016: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28042848/epidemiologic-features-of-enterovirus-71-associated-hand-foot-and-mouth-disease-from-2009-to-2013-in-zhejiang-china
#8
Zhifang Wang, Huakun Lv, Wenming Zhu, Zhe Mo, Guangming Mao, Xiaofeng Wang, Xiaoming Lou, Yongdi Chen
Enterovirus 71 (EV71) usually causes hand-foot-and-mouth disease (HFMD) with severe clinical symptoms and even deaths in China. There is no efficient antiviral drug to protect against severe EV71-associated HFMD, making the development of EV71 vaccines therefore a priority. However, the potential target subject population(s) to be immunized with EV71 vaccine are not well understood. In this study, we characterized the epidemiology regarding EV71-associated HFMD on the basis of provincial-level surveillance...
December 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28030850/changes-of-circulating-th22-cells-in-children-with-hand-foot-and-mouth-disease-caused-by-enterovirus-71-infection
#9
Dawei Cui, Fengyun Zhong, Jie Lin, Yidong Wu, Quan Long, Xianzhi Yang, Qiaoyun Zhu, Li Huang, Qifen Mao, Zhaoxia Huo, Zhe Zhou, Guoliang Xie, Shufa Zheng, Fei Yu, Yu Chen
Interleukin (IL)-22+CD4+T (Th22) cells play crucial roles in the pathogenesis of autoimmune diseases and infectious diseases, although the role of Th22 cells remains largely unclear in children with hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71). This study aims to explore the role of circulating IL-22+IL-17A-CD4+T (cTh22) cells in children with EV71-associated HFMD. We found that during the acute stage of illness, the frequencies of cTh22 and circulating IL-22+IL-17A+CD4+T (IL-22+cTh17) cells in CD4+T cells infrom affected patients, and especially in severely affected patients, were significantly higher than in healthy controls (HC)...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28002441/galectin-3-and-its-genetic-variation-rs4644-modulate-enterovirus-71-infection
#10
Wen-Chan Huang, Hung-Lin Chen, Huan-Yuan Chen, Kuan-Po Peng, Yungling Lee, Li-Min Huang, Luan-Yin Chang, Fu-Tong Liu
Galectin-3, a chimeric type β-galactoside-binding protein, is known to modulate viral infection; however, its role in enterovirus 71 (EV71) infection has not been investigated. We generated galectin-3 null rhabdomyosarcoma (RD) cells and evaluated whether EV71 infection would be affected. In galectin-3 null cells, the released and intracellular EV71 viral loads were suppressed after 24 h of infection, and cell death rates were significantly lower, while cell proliferation remained unaltered. In addition, RD cells expressing a nonsynonymous genetic variant of galectin-3, rs4644 (LGALS3 +191C/A, P64H), produced lower virus titers than those with wild-type galectin-3 (C allele)...
2016: PloS One
https://www.readbyqxmd.com/read/27998409/-epidemiologic-features-of-hand-foot-mouth-disease-in-haikou-city-from-2008-to-2015
#11
C Y Lin, M C Wang, X P Zeng, S Z Kuang, X B Lin
Objective: To analyze the epidemiologic features of hand-foot-mouth disease (HFMD) in Haikou city from 2008 to 2015. Methods: Descriptive methods on epidemiology and detection on pathogens were conducted in Haikou city from 2008 to 2015. Results: A total of 71 611 patients were diagnosed as HFMD in Haikou city from 2008 to 2015, including 728 severe cases, accounting for 1.02% among all the cases. The average annual incidence was 458.89/100 000. A total of 11 deaths were caused by the disease, with the average annual mortality rate as 0...
December 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27974562/in-vivo-imaging-with-bioluminescent-enterovirus-71-allows-for-real-time-visualization-of-tissue-tropism-and-viral-spread
#12
Elizabeth A Caine, Jorge E Osorio
: Hand, foot, and mouth disease (HFMD) is a re-emerging illness caused by a variety of enteroviruses. The main causative agents are enterovirus 71 (EV71), Coxsackievirus A16 (CVA16), and most recently Coxsackievirus A6 (CVA6). Infections of enteroviruses can vary from asymptomatic, mild fever and blisters on infected individual's hands, feet, and throat, to severe neurological complications. Viral persistence has also been documented for weeks post infection (w.p.i.) by demonstration of virus in the stool of children...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27941929/characterization-of-enterovirus-71-infection-and-associated-outbreak-of-hand-foot-and-mouth-disease-in-shawo-of-china-in-2012
#13
Michelle Y Liu, Jin Liu, Weijian Lai, Jun Luo, Yingle Liu, Gia-Phong Vu, Zhu Yang, Phong Trang, Hongjian Li, Jianguo Wu
Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment and prevention of the associated HFMD outbreaks. In this report, we studied an outbreak of 105 HFMD cases in Shawo Township of China between September to October 2012. More than 90% of cases were children younger than 9 years old, with over 50% of cases aged 3-6 years old...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934956/placental-antibody-transfer-efficiency-and-maternal-levels-specific-for-measles-coxsackievirus-a16-enterovirus-71-poliomyelitis-i-iii-and-hiv-1-antibodies
#14
Chuanxi Fu, Long Lu, Hao Wu, Jeffrey Shaman, Yimin Cao, Fang Fang, Qiongying Yang, Qing He, Zhicong Yang, Ming Wang
Maternal antibodies transported across the placenta can provide vital immunity against infectious pathogens for infants. We here examine maternal antibody (MA) levels and their association with neonatal antibody levels. Pregnant women of gestational age ≥35 weeks were enrolled at a Guangzhou China hospital and mother-infant paired sera were collected. Measles IgG antibody was detected using ELISA assay, neutralizing antibodies titers against coxsackievirus A16 (CA16), enterovirus 71 (EV71), PV I-III and HIV-1 were performed...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27929745/an-elaborate-landscape-of-the-human-antibody-repertoire-against-enterovirus-71-infection-is-revealed-by-phage-display-screening-and-deep-sequencing
#15
Zhe Chen, Xianwen Ren, Jian Yang, Jie Dong, Ying Xue, Lilian Sun, Yafang Zhu, Qi Jin
Enterovirus 71 (EV71) causes outbreaks of hand, foot and mouth disease (HFMD), primarily in the Asia-Pacific area, that are often associated with complications of severe to fatal neurological symptoms. There are currently no anti-viral therapies or vaccines available for the treatment of EV71 infection. Illustrating human antibody responses neutralizing EV71 infection could potentially provide valuable information for the development of effective therapies and vaccines. Here, we constructed a comprehensive phage display library based on peripheral blood of eight EV71-infected donors and identified 27 EV71-specific human antibodies, of which four have neutralizing activity in in vitro experiments...
December 8, 2016: MAbs
https://www.readbyqxmd.com/read/27927278/comparative-genomic-analysis-of-enterovirus-71-revealed-six-new-potential-neurovirulence-associated-sites
#16
Qing Jun Jia, Xin Yu Chen, De Zhou Li, Juan Juan Xu, Zhi Gang Xu, Zhi Liang Duan, Jin Sheng Wen
In the present study, the complete genomes of four common (4/EV71/Wenzhou/CHN/2014, 15/ EV71/Wenzhou/CHN/2014, 116/EV71/Wenzhou/ CHN/2014, and 120/EV71/Wenzhou/CHN/2014) and two virulent (11/EV71/Wenzhou/CHN/2014 and 109/EV71/Wenzhou/CHN/2014) enterovirus 71 (EV71) isolates were sequenced and described. They are 7405 bp in length and belong to EV71 sub-genotype C4 (C4a cluster). Nucleotide sequence alignment revealed six nucleotide variations (GP151→TP151, GP199→AP199, GP261→TP261, AP328→CP328, GP422→AP422, and GP437→TP437) in the two virulent isolates within the 5'UTR of the IRES element...
October 2016: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/27907970/-epidemiology-etiology-and-clinical-picture-of-enteroviral-meningitis-in-children-in-south-moravia
#17
Adriana Braunová, Petra Rainetová, Lenka Krbková, Iva Čapovová, Lenka Klapačová, Václav Musil, Martin Musílek, Jana Bednářová
OBJECTIVES: Enteroviruses (EVs) are the most common cause of aseptic viral meningitis. In some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. The objectives were to describe the epidemiological situation of EV meningitis in children in South Moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation. MATERIAL AND METHODS: A total of 88 children with EV meningitis were prospectively evaluated...
September 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27905343/unilateral-hemorrhagic-maculopathy-an-uncommon-manifestation-of-hand-foot-and-mouth-disease
#18
Manish Tandon, Abhishek Gupta, Priyanka Singh, Gnanavelu N Subathra
Hand, foot, and mouth disease (HFD) is a common systemic infection occurring in childhood or immunocompromised adults caused by enteroviruses, the most common being coxsackievirus A16 and enterovirus 71. It is characterized by maculopapular eruptions over the hands and feet and ulcerative stomatitis. Ocular involvement is a rare complication and commonly manifests as inflammatory macular pathology. We report a case of HFD in an immunocompetent adult male with unilateral ocular involvement presenting as hemorrhagic maculopathy and its management with complete anatomical and functional recovery...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27902385/motor-coordination-and-balance-measurements-reveal-differential-pathogenicity-of-currently-spreading-enterovirus-71-strains-in-human-scarb2-transgenic-mice
#19
Mei-Feng Chen, Shin-Ru Shih
Enterovirus 71 (EV71) has caused large-scale epidemics with neurological complications in the Asia-Pacific region. The C4a and B5 strains are the two major genotypes circulating in many countries recently. This study used a new protocol, a motor coordination task, to assess the differential pathogenicity of C4a and B5 strains in human SCARB2 transgenic mice. We found that the pathogenicity of C4a viruses was more severe than that of B5 viruses. Moreover, we discovered that an increased level of monocyte chemoattractant protein-1 was positively correlated with severely deficient motor function...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27894305/identification-of-molecular-determinants-of-cell-culture-growth-characteristics-of-enterovirus-71
#20
Pinn Tsin Isabel Yee, Kuan Onn Tan, Iekhsan Othman, Chit Laa Poh
BACKGROUND: Hand, foot and mouth disease is caused by Enterovirus 71 (EV-A71) and Coxsackieviruses. EV-A71 infection is associated with high fever, rashes and ulcers but more severe symptoms such as cardiopulmonary failure and death have been reported. The lack of vaccines highlighted the urgency of developing preventive agents against EV-A71. The molecular determinants of virulent phenotypes of EV-A71 is unclear. It remains to be investigated if specific molecular determinants would affect the cell culture growth characteristics of the EV-A71 fatal strain in Rhabdomyosarcoma (RD) cells...
November 28, 2016: Virology Journal
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