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Enterovirus 71

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https://www.readbyqxmd.com/read/27907970/-epidemiology-etiology-and-clinical-picture-of-enteroviral-meningitis-in-children-in-south-moravia
#1
Adriana Braunová, Petra Rainetová, Lenka Krbková, Iva Čapovová, Lenka Klapačová, Václav Musil, Martin Musílek, Jana Bednářová
OBJECTIVES: Enteroviruses (EVs) are the most common cause of aseptic viral meningitis. In some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. The objectives were to describe the epidemiological situation of EV meningitis in children in South Moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation. MATERIAL AND METHODS: A total of 88 children with EV meningitis were prospectively evaluated...
September 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27905343/unilateral-hemorrhagic-maculopathy-an-uncommon-manifestation-of-hand-foot-and-mouth-disease
#2
Manish Tandon, Abhishek Gupta, Priyanka Singh, Gnanavelu N Subathra
Hand, foot, and mouth disease (HFD) is a common systemic infection occurring in childhood or immunocompromised adults caused by enteroviruses, the most common being coxsackievirus A16 and enterovirus 71. It is characterized by maculopapular eruptions over the hands and feet and ulcerative stomatitis. Ocular involvement is a rare complication and commonly manifests as inflammatory macular pathology. We report a case of HFD in an immunocompetent adult male with unilateral ocular involvement presenting as hemorrhagic maculopathy and its management with complete anatomical and functional recovery...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27902385/motor-coordination-and-balance-measurements-reveal-differential-pathogenicity-of-currently-spreading-ev71-strains-in-human-scarb2-transgenic-mice
#3
Mei-Feng Chen, Shin-Ru Shih
Enterovirus 71 (EV71) has caused large-scale epidemics with neurological complications in Asia Pacific region. The C4a and B5 strains are the two major genotypes circulalted in many coutries recently. This study provides a new protocol, a motor coordination task, to assess the differential pathogenicity of C4a and B5 strains in human SCARB2 transgenic mice. We found that the pathogenicity of C4a viruses was more severe than that of B5 viruses. Moreover, we discovered that an increased level of monocyte chemoattractant protein-1 is positively correlated with severely deficient motor function...
October 20, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27894305/identification-of-molecular-determinants-of-cell-culture-growth-characteristics-of-enterovirus-71
#4
Pinn Tsin Isabel Yee, Kuan Onn Tan, Iekhsan Othman, Chit Laa Poh
BACKGROUND: Hand, foot and mouth disease is caused by Enterovirus 71 (EV-A71) and Coxsackieviruses. EV-A71 infection is associated with high fever, rashes and ulcers but more severe symptoms such as cardiopulmonary failure and death have been reported. The lack of vaccines highlighted the urgency of developing preventive agents against EV-A71. The molecular determinants of virulent phenotypes of EV-A71 is unclear. It remains to be investigated if specific molecular determinants would affect the cell culture growth characteristics of the EV-A71 fatal strain in Rhabdomyosarcoma (RD) cells...
November 28, 2016: Virology Journal
https://www.readbyqxmd.com/read/27890633/comparison-analysis-of-micrornas-in-response-to-ev71-and-ca16-infection-in-human-bronchial-epithelial-cells-by-high-throughput-sequencing-to-reveal-differential-infective-mechanisms
#5
Yajie Hu, Jie Song, Longding Liu, Jing Li, Beibei Tang, Ying Zhang, Jingjing Wang, Lichun Wang, Shengtao Fan, Ming Feng, Qihan Li
Hand, foot, and mouth disease (HFMD) mainly caused by Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) infections which presented significantly different clinical manifestations. Nevertheless, the factors underlying these differences remain unclear. Recently, the functions of microRNAs (miRNAs) in pathogen-host interactions have been highlighted. Here, we performed comprehensive miRNA profiling in EV71- and CA16-infected human bronchial epithelial (16HBE) cells at multiple time points using high-throughput sequencing...
November 24, 2016: Virus Research
https://www.readbyqxmd.com/read/27888461/inhibitory-effects-of-bee-venom-and-its-components-against-viruses-in-vitro-and-in-vivo
#6
Md Bashir Uddin, Byeong-Hoon Lee, Chamilani Nikapitiya, Jae-Hoon Kim, Tae-Hwan Kim, Hyun-Cheol Lee, Choul Goo Kim, Jong-Soo Lee, Chul-Joong Kim
Bee venom (BV) from honey bee (Apis Melifera L.) contains at least 18 pharmacologically active components including melittin (MLT), phospholipase A2 (PLA2), and apamin etc. BV is safe for human treatments dose dependently and proven to possess different healing properties including antibacterial and antiparasitidal properties. Nevertheless, antiviral properties of BV have not well investigated. Hence, we identified the potential antiviral properties of BV and its component against a broad panel of viruses. Co-incubation of non-cytotoxic amounts of BV and MLT, the main component of BV, significantly inhibited the replication of enveloped viruses such as Influenza A virus (PR8), Vesicular Stomatitis Virus (VSV), Respiratory Syncytial Virus (RSV), and Herpes Simplex Virus (HSV)...
December 2016: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/27875274/sirt1-inhibits-ev71-genome-replication-and-rna-translation-by-interfering-viral-polymerase-and-5-utr-rna
#7
Yang Han, Lvyin Wang, Jin Cui, Yu Song, Zhen Luo, Junbo Chen, Ying Xiong, Qi Zhang, Fang Liu, Wenzhe Ho, Yingle Liu, Kailang Wu, Jianguo Wu
Enterovirus 71 (EV71) possesses a single-stranded positive RNA genome that contains a single open reading frame (ORF) flanked by a 5'untranslated region (5'UTR) and a polyadenylated 3'UTR. Here, we demonstrated that EV71 activates the production of silent mating type information regulation 2 homolog 1 (SIRT1), a histone deacetylase (HDAC). EV71 further stimulates SIRT1 sumoylation and deacetylase activity, and enhances SIRT1 translocation from nuclear to cytoplasm. More interestingly, activated SIRT1 subsequently binds with EV71 3D protein (a viral RNA-dependent RNA polymerase, RdRp) to repress the acetylation and RdRp activity of 3D, resulting in the attenuation of viral genome replication...
November 14, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27873071/development-of-a-fluorescence-resonance-energy-transfer-based-intracellular-assay-to-identify-novel-enterovirus-71-antivirals
#8
Wen-Wen Lu, Fang-Yen Kung, Po-An Deng, Yu-Chu Lin, Cheng-Wen Lin, Szu-Hao Kung
Enterovirus 71 (EV71) is considered one of the most virulent pathogens in the family Picornaviridae. However, there have been no effective treatments for the severe complications caused by EV71. Development of new drugs against targets that are essential for viral replication often requires screening large collections of compounds, for which a high-throughput screening platform is needed. In this study, a drug-screening platform was developed based on a genetically engineered cell line that displays fluorescence resonance energy transfer (FRET) and shows a real-time and quantifiable impairment of FRET upon EV71 infection...
November 21, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27870604/immunoreactivity-analysis-of-the-nonstructural-proteins-of-human-enterovirus-71
#9
Xuyan Chen, Bo Qin, Min Shi, Longying Zhu, Menglin Sun, Xufeng Liu, Jianhua Zhang
Human enterovirus 71 (EV-A71) is one of the main etiological agents of hand, foot, and mouth disease (HFMD), which has been prevalent mainly in the Asia-Pacific region in the past several decades. The nonstructural proteins of EV-A71 will be expressed significantly during viral replication in host cells after EV-A71 infection. For the determination of the antibodies response against nonstructural proteins of EV-A71, in this study, the complete 2ABC, 3ABC, and 3D proteins were expressed in Escherichia coli and were then studied for their immunoreactivity by immunoblot assay and indirect enzyme-linked immunosorbent assay (ELISA), respectively...
November 21, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27859744/hand-foot-and-mouth-disease-an-overview-of-clinical-features-in-adult-patients
#10
I Neri, M A Chessa, A Virdi, A Patrizi
Hand, foot and mouth disease (HFMD) mainly affects children aged <5 years and is caused by several serotypes of enteroviruses, more frequently Enterovirus 71 (EV71) and Coxsackie A16 (CA16)(1) . The disease presents with vesicles in the mouth, hands, feet and buttocks. Only 1% of infected adults develop clinical manifestations, probably as a result of immunological memory(1). Nevertheless, in the atypical HFMD caused by Coxsackie virus A6 (CVA6) the involvement of immunocompetent adults has been recently described(2-6) ...
November 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27855715/erratum-to-antiviral-activity-of-lactobacillus-reuteri-protectis-against-coxsackievirus-a-and-enterovirus-71-infection-in-human-skeletal-muscle-and-colon-cell-lines
#11
Lei Yin Emily Ang, Horng Khit Issac Too, Eng Lee Tan, Tak-Kwong Vincent Chow, Lynette Pei-Chi Shek, Elizabeth Huiwen Tham, Sylvie Alonso
No abstract text is available yet for this article.
November 17, 2016: Virology Journal
https://www.readbyqxmd.com/read/27849036/enterovirus-71-infection-of-motor-neuron-like-nsc-34-cells-undergoes-a-non-lytic-exit-pathway
#12
Issac Horng Khit Too, Huimin Yeo, October Michael Sessions, Benedict Yan, Eshele Anak Libau, Josephine L C Howe, Ze Qin Lim, Shalini Suku-Maran, Wei-Yi Ong, Kaw Bing Chua, Boon Seng Wong, Vincent T K Chow, Sylvie Alonso
Enterovirus 71 (EV71) causing Hand, Foot and Mouth Disease, is regarded as the most important neurotropic virus worldwide. EV71 is believed to replicate in muscles and infect motor neurons to reach the central nervous system (CNS). To further investigate the mechanisms involved, we have employed the motor neuron cell line NSC-34. NSC-34 cells were permissive to EV71 and virus production yields were strain-dependent with differential efficacy at the entry, replication and egress steps. Furthermore, unlike all the other cell lines previously reported, EV71-infected NSC-34 cells neither displayed cytopathic effect nor underwent apoptosis...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27848175/glucocorticoids-prevent-enterovirus-71-capsid-protein-vp1-induced-calreticulin-surface-exposure-by-alleviating-neuronal-er-stress
#13
Dan-Dan Hu, Jian-Ning Mai, Li-Ya He, Pei-Qing Li, Wen-Xiong Chen, Jian-Jiang Yan, Wei-Dong Zhu, Li Deng, Dan Wei, Di-Hui Liu, Si-Da Yang, Zhi-Bin Yao
Severe hand-foot-and-mouth disease (HFMD) caused by Enterovirus 71 (EV71) always accompanies with inflammation and neuronal damage in the central nervous system (CNS). During neuronal injuries, cell surface-exposed calreticulin (Ecto-CRT) is an important mediator for primary phagocytosis of viable neurons by microglia. Our data confirmed that brainstem neurons underwent neuronophagia by glia in EV71-induced death cases of HFMD. EV71 capsid proteins VP1, VP2, VP3, or VP4 did not induce apoptosis of brainstem neurons...
November 15, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27847364/enterovirus-71-3c-promotes-apoptosis-through-cleavage-of-pinx1-a-telomere-binding-protein
#14
Jing Li, Yunfang Yao, Yu Chen, Xiao Xu, Yongquan Lin, Zhilong Yang, Wentao Qiao, Juan Tan
: Enterovirus 71 (EV71) is an emerging pathogen causing hand, foot and mouth disease (HFMD) and fatal neurological diseases in infants and young children due to their under-developed immune-competence. EV71 infection can induce cellular apoptosis through a variety of pathways that promotes EV71 release. The viral protease 3C plays an important role in EV71-induced apoptosis. However, the molecular mechanism responsible for 3C-triggered apoptosis remains elusive. Here, we found that EV71 3C directly interacted with PinX1, a telomere binding protein...
November 9, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27843944/systematic-identification-and-bioinformatic-analysis-of-micrornas-in-response-to-infections-of-coxsackievirus-a16-and-enterovirus-71
#15
Zheng Zhu, Yuhua Qi, Huan Fan, Lunbiao Cui, Zhiyang Shi
Hand, foot, and mouth disease (HFMD), mainly caused by coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) infections, remains a serious public health issue with thousands of newly diagnostic cases each year since 2008 in China. The mechanisms underlying viral infection, however, are elusive to date. In the present study, we systematically investigated the host cellular microRNA (miRNA) expression patterns in response to CVA16 and EV71 infections. Through microarray examination, 27 miRNAs (15 upregulated and 12 downregulated) were found to be coassociated with the replication process of two viruses, while the expression levels of 15 and 5 miRNAs were significantly changed in CVA16- and EV71-infected cells, respectively...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27833060/enterovirus-71-genotype-c-isolated-in-peru-between-2006-and-2009
#16
Jose L Huaman, Gladys Carrion, Julia S Ampuero, Victor Ocaña, V Alberto Laguna-Torres, Robert D Hontz
Enterovirus-71 (EV71) was first isolated in California, United States in 1969, belongs to the genus Enterovirus, family Picornaviridae. Although infection normally causes mild, often undiagnosed illness, it can cause central nervous system infections that could turn fatal. Based on VP1 gene analysis, EV71 has been classified into six separate genotypes. Although the molecular epidemiology of EV71 has been well described via studies originating from Asia and Europe, it is mostly unknown in South America. From our study, four EV71 isolates from Peru were characterized using phylogenetic methods to determine their relationship with known reference strains...
November 3, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27826325/enterovirus-71-infection-and-neurological-complications
#17
REVIEW
Kyung Yeon Lee
Since the outbreak of the enterovirus 71 (EV71) infection in Malaysia in 1997, large epidemics of EV71 have occurred in the Asia-Pacific region. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas. EV71 infection causes hand, foot and mouth disease (HFMD) in children, and usually resolves spontaneously. However, EV71 occasionally involves the central nervous system (CNS), and induces diverse neurological complications such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27819276/children-s-caregivers-and-public-playgrounds-potential-reservoirs-of-infection-of-hand-foot-and-mouth-disease
#18
Pengyuan Li, Tao Li, Qiuyun Gu, Xiaomin Chen, Jiahui Li, Xiashi Chen, Yan Chen, Danwei Zhang, Rong Gao, Zhenjian He, Xun Zhu, Wangjian Zhang, Yuantao Hao, Dingmei Zhang
Hand-foot-and-mouth disease (HFMD) is a common infectious disease, which has led to millions of clinical cases and hundreds of deaths every year in China. This study aimed to exploring the effects on HFMD transmission of children's caregivers and public area, as well as trying to locate the potential reservoirs of infections in primary cases. Total children's 257 samples (98 children's caregivers and 159 environmental samples) were tested for the presence of universal enterovirus, enterovirus 71, coxsackie virus A6 and A16 by real-time fluorescence quantitative polymerase chain reaction (qPCR)...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27817774/-expression-of-vasoactive-intestinal-peptide-in-peripheral-blood-of-children-with-hand-foot-and-mouth-disease
#19
Jin-Song Ren, Hao-Miao Sun, Lei Zhang, Jing-De Lin, Cheng Wen, Dai-Hua Fang
OBJECTIVE: To investigate the expression of vasoactive intestinal peptide (VIP) in peripheral blood of children with hand, foot and mouth disease and its significance. METHODS: According to the condition of the disease, 86 children with hand, foot and mouth disease were classified into phase 1 group (19 children) and phase 2 group (67 children). ELISA was used to measure the concentrations of plasma VIP, interferon-γ (IFN-γ), and interleukin-4 (IL-4) in peripheral blood...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27816018/sequence-analysis-of-the-first-c2-subgenogroup-strain-of-enterovirus-71-isolated-in-korea
#20
Jung-Ah Lee, Young Sil Yoon, Ji-Yeon Hyeon, Jung Sik Yoo, Sang-Won Lee, June-Woo Lee, Sang-Won Lee
BACKGROUND: Enterovirus 71 (EV71) is an important causative agent of hand-foot-and-mouth disease with severe neurological complications, which may lead to death in children. Large outbreaks caused by EV71 have frequently occurred in Asia-Pacific region. OBJECTIVES: In Korea, the outbreaks have been caused by EV71 subgenogroups C3, and C4. Only genogroup C, especially subgenogroup C1, C3, C4, and C5, has been detected by the national enterovirus surveillance system in Korea...
October 22, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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