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https://www.readbyqxmd.com/read/29150641/repurposing-of-the-anti-malaria-drug-chloroquine-for-zika-virus-treatment-and-prophylaxis
#1
Sergey A Shiryaev, Pinar Mesci, Antonella Pinto, Isabella Fernandes, Nicholas Sheets, Sujan Shresta, Chen Farhy, Chun-Teng Huang, Alex Y Strongin, Alysson R Muotri, Alexey V Terskikh
One of the major challenges of the current Zika virus (ZIKV) epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant women. Given the urgent need for ZIKV prophylaxis and treatment, repurposing of approved drugs appears to be a viable and immediate solution. We demonstrate that the common anti-malaria drug chloroquine (CQ) extends the lifespan of ZIKV-infected interferon signalling-deficient AG129 mice. However, the severity of ZIKV infection in these mice precludes the study of foetal (vertical) viral transmission...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112671/travel-characteristics-and-pretravel-health-care-among-pregnant-or-breastfeeding-u-s-women-preparing-for-international-travel
#2
Stefan H F Hagmann, Sowmya R Rao, Regina C LaRocque, Stefanie Erskine, Emily S Jentes, Allison T Walker, Elizabeth D Barnett, Lin H Chen, Davidson H Hamer, Edward T Ryan
OBJECTIVE: To study characteristics and preventive interventions of adult pregnant and breastfeeding travelers seeking pretravel health care in the United States. METHODS: This cross-sectional study analyzed data (2009-2014) of pregnant and breastfeeding travelers seen at U.S. travel clinics participating in Global TravEpiNet. Nonpregnant, nonbreastfeeding adult female travelers of childbearing age were used for comparison. We evaluated the prescription of malaria chemoprophylaxis and antibiotics for this population as well as the administration of three travel-related vaccines: hepatitis A, typhoid, and yellow fever...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29110709/the-prevalence-incidence-and-prevention-of-plasmodium-falciparum-infections-in-forest-rangers-in-bu-gia-map-national-park-binh-phuoc-province-vietnam-a-pilot-study
#3
Do Hung Son, Nguyen Thuy-Nhien, Lorenz von Seidlein, Truong Le Phuc-Nhi, Ngo Thi Phu, Nguyen Thi Kim Tuyen, Nguyen Huyen Tran, Nguyen Van Dung, Bui Van Quan, Nicholas P J Day, Arjen M Dondorp, Nicholas J White, Guy E Thwaites, Tran Tinh Hien
BACKGROUND: Prophylaxis for high-risk populations, such as forest workers, could be one component for malaria elimination in the Greater Mekong Sub-region. A study was conducted to assess the malaria incidence in forest rangers and the feasibility of malaria prophylaxis for rangers sleeping in forest camps. METHODS: Forest rangers deployed in the Bu Gia Map National Park, Vietnam were invited to participate in the study. Plasmodium infections were cleared using presumptive treatment, irrespective of malaria status, with a 3-day course dihydroartemisinin/piperaquine (DP) and a 14-day course of primaquine...
November 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29107173/deaths-and-parasuicides-associated-with-mefloquine-chemoprophylaxis-a-systematic-review
#4
REVIEW
Maya Tickell-Painter, Rachel Saunders, Nicola Maayan, Vittoria Lutje, Alberto Mateo-Urdiales, Paul Garner
BACKGROUND: Mefloquine is recommended in international health guidelines for preventing malaria in travellers. Reports of psychosis and suicide are often alluded to but are not clearly established. METHODS: We carried out a systematic review to identify and critically appraise any death or parasuicide associated with mefloquine prophylaxis. We developed a comprehensive search that included publications up to 11 July 2017. We included case studies but excluded newspaper reports...
October 25, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29083100/mefloquine-for-preventing-malaria-during-travel-to-endemic-areas
#5
REVIEW
Maya Tickell-Painter, Nicola Maayan, Rachel Saunders, Cheryl Pace, David Sinclair
BACKGROUND: Mefloquine is one of four antimalarial agents commonly recommended for preventing malaria in travellers to malaria-endemic areas. Despite its high efficacy, there is controversy about its psychological side effects. OBJECTIVES: To summarize the efficacy and safety of mefloquine used as prophylaxis for malaria in travellers. SEARCH METHODS: We searched the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register of Controlled Trials (CENTRAL), published on the Cochrane Library; MEDLINE; Embase (OVID); TOXLINE (https://toxnet...
October 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29020345/plasmodium-malariae-in-israeli-travelers-a-nationwide-study
#6
Yarden Yavne, Eyal Leshem, Yael Paran, Eyal Nadir, Miriam Weinberger, Michal Stein, Neta Petersiel, Dafna Yahav, Tamar Grossman, Eli Schwartz
Background: Little is known about Plasmodium malariae, a relatively rare cause of malaria in returned travelers. Recently, polymerase chain reaction (PCR) use for malaria diagnosis has enhanced specificity of P. malariae detection. The study objective was to describe the unique aspects of P. malariae diagnosis and clinical course in travelers. Methods: Malaria is a reportable disease in Israel. All PCR-proven P. malariae monoinfections in Israeli travelers between January 2008 and January 2017 were retrieved from the Ministry of Health Reference Parasitology Laboratory...
August 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017499/imported-malaria-in-spain-2009-2016-results-from-the-redivi-collaborative-network
#7
Francesca F Norman, Ana López-Polín, Fernando Salvador, Begoña Treviño, Eva Calabuig, Diego Torrús, Antonio Soriano-Arandes, Jose-Manuel Ruíz-Giardín, Begoña Monge-Maillo, Jose-Antonio Pérez-Molina, Ana Perez-Ayala, Magdalena García, Azucena Rodríguez, María Martínez-Serrano, Miren Zubero, Rogelio López-Vélez
BACKGROUND: Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored. METHODS: Cases of imported malaria were identified among all cases registered in the +REDIVI database during the period October 2009-October 2016...
October 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28934451/acute-malaria-infection-after-atovaquone-proguanil-prophylaxis
#8
COMMENT
Anna A Minta, Kathrine R Tan, Kimberly E Mace, Paul M Arguin
No abstract text is available yet for this article.
March 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28931128/6-year-review-of-redivi-a-prospective-registry-of-imported-infectious-diseases-in-spain
#9
José A Pérez-Molina, Ana López-Polín, Begoña Treviño, Israel Molina, Josune Goikoetxea, Marta Díaz-Menéndez, Diego Torrús, Eva Calabuig, Agustín Benito, Rogelio López-Vélez
Background: Understanding and detecting imported diseases is a priority in the prevention and management of prevalent and emergent infectious diseases acquired abroad. The +Redivi network measures the burden of imported infections in Spain and is essential for closing the gap in travel medicine. Methods: Demographic characteristics, travel information, syndromes and confirmed travel-related diagnoses were registered in a standardised online database. Results: A total of 10 767 cases of imported infectious diseases were registered between October 2009 and December 2015...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28927276/alkoxycarbonate-ester-prodrugs-of-preclinical-drug-candidate-elq-300-for-prophylaxis-and-treatment-of-malaria
#10
Lisa Frueh, Yuexin Li, Michael W Mather, Qigui Li, Sovitj Pou, Aaron Nilsen, Rolf W Winter, Isaac P Forquer, April M Pershing, Lisa H Xie, Martin J Smilkstein, Diana Caridha, Dennis R Koop, Robert F Campbell, Richard J Sciotti, Mara Kreishman-Deitrick, Jane X Kelly, Brian Vesely, Akhil B Vaidya, Michael K Riscoe
ELQ-300 is a preclinical antimalarial drug candidate that is active against liver, blood, and transmission stages of Plasmodium falciparum. While ELQ-300 is highly effective when administered in a low multidose regimen, poor aqueous solubility and high crystallinity have hindered its clinical development. To overcome its challenging physiochemical properties, a number of bioreversible alkoxycarbonate ester prodrugs of ELQ-300 were synthesized. These bioreversible prodrugs are converted to ELQ-300 by host and parasite esterase action in the liver and bloodstream of the host...
October 13, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28926409/effects-of-concurrent-exposure-to-antiretrovirals-and-cotrimoxazole-prophylaxis-among-hiv-exposed-uninfected-infants
#11
Alexander C Ewing, Caroline C King, Jeffrey B Wiener, Charles S Chasela, Michael G Hudgens, Debbie Kamwendo, Gerald Tegha, Mina C Hosseinipour, Denise J Jamieson, Charles Van der Horst, Athena P Kourtis
BACKGROUND: Given the potential of cotrimoxazole preventive therapy (CPT) to prevent bacterial and malarial infections in HIV-exposed, uninfected (HEU) infants, it is important to evaluate the effects of its concurrent use with antiretroviral agents that have overlapping toxicity profiles. METHODS: We used data from the Breastfeeding, Antiretrovirals, and Nutrition study (2004-2010) to evaluate the association of CPT and antiretrovirals with hematologic measures (hemoglobin, neutrophil, and alanine aminotransferase levels) from 6 to 48 weeks of age in 2006 HEU infants in Lilongwe, Malawi...
November 28, 2017: AIDS
https://www.readbyqxmd.com/read/28895659/implementation-strategies-for-health-systems-in-low-income-countries-an-overview-of-systematic-reviews
#12
REVIEW
Tomas Pantoja, Newton Opiyo, Simon Lewin, Elizabeth Paulsen, Agustín Ciapponi, Charles S Wiysonge, Cristian A Herrera, Gabriel Rada, Blanca Peñaloza, Lilian Dudley, Marie-Pierre Gagnon, Sebastian Garcia Marti, Andrew D Oxman
BACKGROUND: A key function of health systems is implementing interventions to improve health, but coverage of essential health interventions remains low in low-income countries. Implementing interventions can be challenging, particularly if it entails complex changes in clinical routines; in collaborative patterns among different healthcare providers and disciplines; in the behaviour of providers, patients or other stakeholders; or in the organisation of care. Decision-makers may use a range of strategies to implement health interventions, and these choices should be based on evidence of the strategies' effectiveness...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28894556/how-we-manage-invasive-fungal-disease-in-acute-myeloid-leukemia-patients-with-glucose-6-dehydrogenase-deficiency
#13
Marco Sanna, Giovanni Caocci, Giorgio La Nasa
Glucose-6-phosphate dehydrogenase (G6PD) represents a common human enzyme defect, particularly prevalent in the Mediterranean, African e Asian area, where malaria was or is still endemic. Recently, we identified G6PD deficiency as a risk factor for developing invasive fungal disease (IFD) and particularly Candida Sepsis in patients undergoing intensive chemotherapy for acute myeloid leukemia (AML), suggesting that there is an urgent need for strategies to properly manage this kind of patients at high risk of invasive mycoses...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28883977/management-of-plasmodium-vivax-risk-and-illness-in-travelers
#14
EDITORIAL
J Kevin Baird
Malaria poses an exceptionally complex problem for providers of travel medicine services. Perceived high risk of exposure during travel typically prompts prescribing protective antimalarial drugs. Suppressive chemoprophylactic agents have dominated strategy for that practice for over 70 years. This broad class of therapeutic agents kills parasites after they emerge from the liver and attempt development in red blood cells. The dominance of suppressive chemoprophylaxis in travel medicine stems largely from the view of Plasmodium falciparum as the utmost threat to the patient - these drugs are poorly suited to preventing Plasmodium vivax and Plasmodium ovale due to inactivity against the latent liver stages of these species not produced by P...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/28867401/outbreak-of-human-malaria-caused-by-plasmodium-simium-in-the-atlantic-forest-in-rio-de-janeiro-a-molecular-epidemiological-investigation
#15
Patrícia Brasil, Mariano Gustavo Zalis, Anielle de Pina-Costa, Andre Machado Siqueira, Cesare Bianco Júnior, Sidnei Silva, André Luiz Lisboa Areas, Marcelo Pelajo-Machado, Denise Anete Madureira de Alvarenga, Ana Carolina Faria da Silva Santelli, Hermano Gomes Albuquerque, Pedro Cravo, Filipe Vieira Santos de Abreu, Cassio Leonel Peterka, Graziela Maria Zanini, Martha Cecilia Suárez Mutis, Alcides Pissinatti, Ricardo Lourenço-de-Oliveira, Cristiana Ferreira Alves de Brito, Maria de Fátima Ferreira-da-Cruz, Richard Culleton, Cláudio Tadeu Daniel-Ribeiro
BACKGROUND: Malaria was eliminated from southern and southeastern Brazil over 50 years ago. However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. As the P vivax-like non-human primate malaria parasite species Plasmodium simium is locally enzootic, we performed a molecular epidemiological investigation to determine whether zoonotic malaria transmission is occurring. METHODS: We examined blood samples from patients presenting with signs or symptoms suggestive of malaria as well as from local howler monkeys by microscopy and PCR...
August 31, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28852282/the-bone-pain-crisis-of-sickle-cell-disease-and-malaria-observations-from-gujarat-india
#16
Jyotish Patel, Bharati Patel, Graham R Serjeant
BACKGROUND: Sickle cell disease is a common problem across central India, but its clinical features may differ from that in African populations. There is a need to define the features of sickle cell disease in India, and the current study addresses some features of the bone pain crisis. OBJECTIVES: The objective of the study was to describe the epidemiology of the bone pain crisis of sickle cell disease in Gujarat and explore the relationship with infection by Plasmodium vivax...
July 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28805982/a-serious-nightmare-psychiatric-and-neurologic-adverse-reactions-to-mefloquine-are-serious-adverse-reactions
#17
Remington L Nevin
Mefloquine (originally marketed as Lariam) is a neurotoxic quinoline derivative antimalarial drug that is known to cause serious and potentially lasting neuropsychiatric adverse reactions. Since 2013, drug regulators in several jurisdictions, including the United States, the United Kingdom, Ireland, and Canada, have required their mefloquine labels be updated to warn that when used for malaria prophylaxis the drug should be discontinued at the onset of neurologic or psychiatric symptoms. These recent changes to the international labeling serve to imply that psychiatric and neurologic reactions to mefloquine prophylaxis may be an early warning of an impending more serious reaction that may further jeopardize the patient with continued use of the drug...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28722601/rabies-in-myanmar-prevalent-preventable-but-not-prioritized
#18
COMPARATIVE STUDY
Thet Thet Mu, Aye Aye Sein, Chit Soe, Nan Phyu Phyu Aung, Tint Tint Kyi, Josh Hanson
Despite the availability of proven measures to prevent the disease, rabies now kills more people in Myanmar than malaria. Although there are challenges in controlling rabies in such a large and culturally diverse country, Myanmar's successful National Malaria Control Program demonstrates what can be achieved with sufficient political, financial, and scientific commitment. Presently, however, Myanmar lacks a comparable program to coordinate the multifaceted approach that is necessary to control rabies. The national government has invested heavily in improving access to postexposure prophylaxis, but there should also be an emphasis on other, more cost-effective strategies, particularly mass canine vaccination, which has been an essential component of successful rabies elimination programs in other countries...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28683669/development-of-loop-mediated-isothermal-amplification-with-plasmodium-falciparum-unique-genes-for-molecular-diagnosis-of-human-malaria
#19
Yijing Zhang, Yi Yao, Weixing Du, Kai Wu, Wenyue Xu, Min Lin, Huabing Tan, Jian Li
In order to achieve better outcomes for treatment and in the prophylaxis of malaria, it is imperative to develop a sensitive, specific, and accurate assay for early diagnosis of Plasmodium falciparum infection, which is the major cause of malaria. In this study, we aimed to develop a loop-mediated isothermal amplification (LAMP) assay with P. falciparum unique genes for sensitive, specific, and accurate detection of P. falciparum infection. The unique genes of P. falciparum were randomly selected from PlasmoDB...
July 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28680367/cost-effectiveness-analysis-of-malaria-interventions-using-disability-adjusted-life-years-a-systematic-review
#20
REVIEW
Resign Gunda, Moses John Chimbari
BACKGROUND: Malaria continues to be a public health problem despite past and on-going control efforts. For sustenance of control efforts to achieve the malaria elimination goal, it is important that the most cost-effective interventions are employed. This paper reviews studies on cost-effectiveness of malaria interventions using disability-adjusted life years. METHODS: A review of literature was conducted through a literature search of international peer-reviewed journals as well as grey literature...
2017: Cost Effectiveness and Resource Allocation: C/E
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