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https://www.readbyqxmd.com/read/28722601/rabies-in-myanmar-prevalent-preventable-but-not-prioritized
#1
Thet Thet Mu, Aye Aye Sein, Chit Soe, Nan Phyu Phyu Aung, Tint Tint Kyi, Josh Hanson
Despite the availability of proven measures to prevent the disease, rabies now kills more people in Myanmar than malaria. Although there are challenges in controlling rabies in such a large and culturally diverse country, Myanmar's successful National Malaria Control Program demonstrates what can be achieved with sufficient political, financial, and scientific commitment. Presently, however, Myanmar lacks a comparable program to coordinate the multifaceted approach that is necessary to control rabies. The national government has invested heavily in improving access to postexposure prophylaxis, but there should also be an emphasis on other, more cost-effective strategies, particularly mass canine vaccination, which has been an essential component of successful rabies elimination programs in other countries...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28683669/development-of-loop-mediated-isothermal-amplification-with-plasmodium-falciparum-unique-genes-for-molecular-diagnosis-of-human-malaria
#2
Yijing Zhang, Yi Yao, Weixing Du, Kai Wu, Wenyue Xu, Min Lin, Huabing Tan, Jian Li
In order to achieve better outcomes for treatment and in the prophylaxis of malaria, it is imperative to develop a sensitive, specific, and accurate assay for early diagnosis of Plasmodium falciparum infection, which is the major cause of malaria. In this study, we aimed to develop a loop-mediated isothermal amplification (LAMP) assay with P. falciparum unique genes for sensitive, specific, and accurate detection of P. falciparum infection. The unique genes of P. falciparum were randomly selected from PlasmoDB...
July 6, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28680367/cost-effectiveness-analysis-of-malaria-interventions-using-disability-adjusted-life-years-a-systematic-review
#3
REVIEW
Resign Gunda, Moses John Chimbari
BACKGROUND: Malaria continues to be a public health problem despite past and on-going control efforts. For sustenance of control efforts to achieve the malaria elimination goal, it is important that the most cost-effective interventions are employed. This paper reviews studies on cost-effectiveness of malaria interventions using disability-adjusted life years. METHODS: A review of literature was conducted through a literature search of international peer-reviewed journals as well as grey literature...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28669839/optimal-antimalarial-dose-regimens-for-chloroquine-in-pregnancy-based-on-population-pharmacokinetic-modelling
#4
Sam Salman, Francesca Baiwog, Madhu Page-Sharp, Kay Kose, Harin A Karunajeewa, Ivo Mueller, Stephen J Rogerson, Peter M Siba, Kenneth F Ilett, Timothy M E Davis
Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dose regimens could be developed specifically for pregnant women. Such optimized CQ-based regimens, used as treatment for acute malaria or as intermittent preventive treatment in pregnancy (IPTp), may have a valuable role if parasite CQ sensitivity returns following reduced drug pressure. In this study, population pharmacokinetic-pharmacodynamic modelling was used to simultaneously analyze plasma concentration-time data for CQ and its active metabolite desethylchloroquine (DCQ) in 44 non-pregnant and 45 pregnant Papua New Guinean women treated with CQ and sulfadoxine-pyrimethamine (SP) or azithromycin (AZI)...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28654740/evaluation-of-knowledge-and-use-of-the-malaria-prevention-measures-among-the-patients-of-the-department-of-tropical-and-parasitic-diseases-university-center-of-maritime-and-tropical-medicine-gdynia-based-on-a-questionnaire-performed-in-the-years-2012-20
#5
Anna Kuna, Michał Gajewski, Joanna Stańczak
INTRODUCTION: Every year, approximately 125 million travelers visit areas where malaria prevails, located in over 100 countries. Over 10,000 of them suffer from malaria annually. Visitors to these areas may protect themselves against infection by using chemoprophylaxis, insect repellents, appropriate clothing, sleeping in airconditioned and well-screened quarters or using mosquito nets impregnated with insecticides. AIM OF THE STUDY: The aim of this study was to gather and analyze the data about knowledge and usage of pharmacological and non-pharmacological malaria prevention methods among the patients of the University Centre for Maritime and Tropical Medicine (UCMMiT), Gdynia, Poland, in 2012-2013...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28653454/effect-of-cotrimoxazole-prophylaxis-on-malaria-occurrence-among-hiv-infected-adults-in-west-africa-the-malhiv-study
#6
Serge P Eholié, Frédéric N Ello, Patrick A Coffie, Arsène Héma, Daouda K Minta, Adrien Sawadogo
INTRODUCTION: Cotrimoxazole (CTX) should be given to all HIV-infected adults with mild or severe HIV disease or those with CD4 counts below 350/mm(3) according to 2006 WHO guidelines. We assessed the impact of CTX prophylaxis on the risk of malaria episodes in HIV-1 infected adults from four West African countries with different patterns of malaria transmission. METHOD: Multicentric cohort study, conducted between September 2007 and March 2010 in four West African cities...
June 27, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28630942/antimalarial-drugs-and-the-prevalence-of-mental-and-neurological-manifestations-a-systematic-review-and-meta-analysis
#7
Mary A Bitta, Symon M Kariuki, Clifford Mwita, Samson Gwer, Leah Mwai, Charles R J C Newton
Background: Antimalarial drugs affect the central nervous system, but it is difficult to differentiate the effect of these drugs from that of the malaria illness. We conducted a systematic review to determine the association between anti-malarial drugs and mental and neurological impairment in humans.  Methods: We systematically searched online databases, including Medline/PubMed, PsychoInfo, and Embase, for articles published up to 14th July 2016. Pooled prevalence, heterogeneity and factors associated with prevalence of mental and neurological manifestations were determined using meta-analytic techniques...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28619415/international-travelers-sociodemographic-health-and-travel-characteristics-an-italian-study
#8
Gianmarco Troiano, Astrid Mercone, Alessandra Bagnoli, Nicola Nante
BACKGROUND: Approximately the 8% of travelers requires medical care, with the diagnosis of a vaccine-preventable disease. The aim of our study was to analyze the socio-demographic, health and travel characteristics of the Italian international travelers. METHODS: We conducted a cross sectional study from January 2015 to June 2016, at the Travel Medicine Clinic of Siena, asking the doctor to interview patients who attended the Clinic, recording socio-demographic and travel information, malaria prophylaxis, vaccinations...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28596841/targeting-endosomal-acidification-by-chloroquine-analogs-as-a-promising-strategy-for-the-treatment-of-emerging-viral-diseases
#9
REVIEW
Md Abdul Alim Al-Bari
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28593051/the-need-for-preventive-and-curative-services-for-malaria-when-the-military-is-deployed-in-endemic-overseas-territories-a-case-study-and-lessons-learned
#10
Sumadhya Deepika Fernando, Rahuman Booso, Priyani Dharmawardena, Arunagirinathan Harintheran, Kugapiriyan Raviraj, Chaturaka Rodrigo, Manjula Danansuriya, Rajitha Wickremasinghe
BACKGROUND: Sri Lanka has been free from indigenous malaria since November 2012 and received the WHO certificate for malaria-free status in September 2016. Due to increased global travel, imported malaria cases continue to be reported in the country. Military personnel returning home from international peace-keeping missions in malaria endemic countries represent a key risk group in terms of imported malaria. The present study intended to characterize the potential causes of a malaria outbreak among the Sri Lankan security forces personnel deployed in the Central African Republic (CAR)...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28583709/imported-malaria-in-pregnant-women-experienced-in-japan
#11
Mikio Kimura, Michiko Koga, Chihiro Hasegawa, Yoshikazu Mutoh, Yasuyuki Kato, Haruhiko Maruyama
INTRODUCTION: With ever-growing global exchanges, the number of travelers, including pregnant women, to the tropics is increasing, which poses a risk of contracting malaria. Although there are several reports on imported malaria in pregnancy from Western countries, those focusing on cases experienced in Japan are very limited. METHODS: We searched for cases of malaria in pregnancy in the treatment records submitted to the Research Group on Chemotherapy of Tropical Diseases, Japan, during the period 1993-2016...
August 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28572077/assessment-of-adherence-to-malaria-chemoprophylaxis-in-a-french-navy-frigate-deployed-in-southeast-asia
#12
B Nicolas, L Papillault des Charbonnières, T Vasseur, P Mauclere
During a 2-month mission in Southeast Asia, including numerous stopovers in coastal cities, the crew of a frigate of the French Navy received doxycycline for antimalarial prophylaxis. Adherence to this chemoprophylaxis was evaluated with an anonymous questionnaire distributed at the end of the malaria exposure period. The response rate was 74 % (72 crew members). Among them, 67 sailors felt they had received clear information about the risks of malaria. Overall, 19 (27 %) respondents reported adherence (one forgotten pill, by no more than 15 days), 18 (25 %) irregular adherence (one or more pills forgotten weekly or stopped during the mission), and 35 recognized that they had not taken the treatment...
June 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28567199/frequent-malaria-illness-episodes-in-two-malawian-patients-on-antiretroviral-therapy-soon-after-stopping-cotrimoxazole-preventive-therapy
#13
Wongani Js Nyangulu, Edson Mwinjiwa, Titus H Divala, Randy G Mungwira, Osward Nyirenda, Maxwell Kanjala, Gillian Mbambo, Jane Mallewa, Terrie E Taylor, Matthew B Laurens, Miriam K Laufer, Joep J van Oosterhout
We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.
March 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28526056/the-blood-schizonticidal-activity-of-tafenoquine-makes-an-essential-contribution-to-its-prophylactic-efficacy-in-nonimmune-subjects-at-the-intended-dose-200%C3%A2-mg
#14
REVIEW
Geoffrey Dow, Bryan Smith
Tafenoquine (TQ) is an 8-aminoquinoline anti-malarial being developed for malaria prophylaxis. It has been generally assumed that TQ, administered prophylactically, acts primarily on the developing exoerythrocytic stages of malaria parasites (causal prophylaxis), and that polymorphisms in metabolic enzymes thought to impact the activity of other 8-aminoquinolines also inhibit this property of TQ. Furthermore, it has been suggested that a diagnostic test for CYP2D6 metabolizer status might be required. In field studies in which metabolic status was not an exclusion criteria, TQ has been shown to exhibit similar prophylactic efficacy as blood schizonticidal drugs (mefloquine)...
May 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28495354/tafenoquine-for-malaria-prophylaxis-in-adults-an-integrated-safety-analysis
#15
Anne Novitt-Moreno, Janet Ransom, Geoffrey Dow, Bryan Smith, Lisa Thomas Read, Stephen Toovey
BACKGROUND: Tafenoquine is a new prophylactic antimalarial drug. The current analysis presents an integrated safety assessment of the Tafenoquine Anticipated Clinical Regimen (Tafenoquine ACR) from 5 clinical trials, including 1 conducted in deployed military personnel and 4 in non-deployed residents, which also incorporated placebo and mefloquine comparator groups. METHODS: Adverse events (AEs) were coded according to the Medical Dictionary for Regulatory Activities (MedDRA(®), Version 15...
May 8, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28491482/long-term-prophylaxis-and-pharmacokinetic-evaluation-of-intramuscular-nano-and-microparticle-decoquinate-in-mice-infected-with-p-berghei-sporozoites
#16
Qigui Li, Lisa Xie, Diana Caridha, Qiang Zeng, Jing Zhang, Norma Roncal, Ping Zhang, Chau Vuong, Brittney Potter, Jason Sousa, Sean Marcsisin, Lisa Read, Mark Hickman
Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were conducted at various single intramuscular-decoquinate doses for 2, 4, 6, or 8 weeks prior to infection with P. berghei sporozoites. The liver stage efficacy evaluation was monitored by using an in vivo imaging system. Full causal prophylaxis was shown in mice with a single intramuscular dose at 120 mg/kg of nanoparticle decoquinate (0...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28487213/long-term-health-outcomes-among-returned-peace-corps-volunteers-after-malaria-prophylaxis-1995-2014
#17
Kathrine R Tan, Susan J Henderson, John Williamson, Rennie W Ferguson, Thomas M Wilkinson, Paul Jung, Paul M Arguin
BACKGROUND: A primary reason for non-adherence to malaria chemoprophylaxis is fear of latent side effects. We examined latent effects of malaria chemoprophylaxis among Returned Peace Corps Volunteers (RPCVs). METHODS: During July 18-September 16, 2016, RPCVs who served during 1995-2014 with an e-mail address in Peace Corps' RPCV database were invited to take an internet-based survey on malaria prophylaxis and medical diagnoses. "Good adherence" meant taking prophylaxis "as prescribed" or "most of the time...
May 6, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28460165/development-of-a-rapidly-dissolvable-oral-pediatric-formulation-for-mefloquine-using-liposomes
#18
Wei-Lun Tang, Wei-Hsin Tang, Weihsu Claire Chen, Charles Diako, Carolyn F Ross, Shyh-Dar Li
Mefloquine (Mef), a poorly soluble and highly bitter drug, has been used for malaria prophylaxis and treatment. The dosage form for Mef is mostly available as adult tablets, and thus children under the age of 5 suffer from poor medication adherence. We have developed a stable, rapidly dissolvable, and palatable pediatric formulation for Mef using liposomes composed of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol with a mean diameter of ∼110 nm. Mef was actively loaded into the liposomes via an ammonium sulfate gradient using the solvent-assisted loading technology (SALT) developed in our lab...
May 9, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28444232/co-trimoxazole-prophylaxis-asymptomatic-malaria-parasitemia-and-infectious-morbidity-in-hiv-exposed-uninfected-infants-in-malawi-the-ban-study
#19
Nicole L Davis, Jeffrey Wiener, Jonathan J Juliano, Linda Adair, Charles S Chasela, Dumbani Kayira, Michael G Hudgens, Charles van der Horst, Denise J Jamieson, Athena P Kourtis
Background: HIV-exposed infants are disproportionately at risk of morbidity and mortality compared with their HIV-unexposed counterparts. The role of co-trimoxazole preventive therapy (CPT) in reducing leading causes of infectious morbidity is unclear. Methods: We used data from the Breastfeeding, Antiretrovirals and Nutrition (BAN) clinical trial (conducted 2004-2010, Malawi) to assess the association of 1) CPT and 2) asymptomatic malaria parasitemia with respiratory and diarrheal morbidity in infants...
April 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28439418/prevention-practices-influencing-frequency-of-occurrence-of-vaso-occlusive-crisis-among-sickle-cell-patients-in-abeokuta-south-local-government-area-of-ogun-state-nigeria
#20
Olorunfemi Emmanuel Amoran, Ahmed Babatunde Jimoh, Omotola Ojo, Temitope Kuponiyi
BACKGROUND: Africa is the most affected continent with 200,000 new born affected by sickle cell anemia annually with of 5% of under five deaths. Nigeria has the largest sickle cell gene pool in the world with about 2% of all babies born to Nigerian parents. This study therefore sets out to assess the prevention practices influencing the frequency of occurrence of vaso-occlusive crisis among patients in Ogun State. METHODS: This study is a descriptive cross-sectional study conducted in Abeokuta South Local Government Area Ogun State...
2017: BMC Hematology
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