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https://www.readbyqxmd.com/read/28628617/comparative-analysis-of-european-bat-lyssavirus-1-pathogenicity-in-the-mouse-model
#1
Elisa Eggerbauer, Florian Pfaff, Stefan Finke, Dirk Höper, Martin Beer, Thomas C Mettenleiter, Tobias Nolden, Jens-Peter Teifke, Thomas Müller, Conrad M Freuling
European bat lyssavirus 1 is responsible for most bat rabies cases in Europe. Although EBLV-1 isolates display a high degree of sequence identity, different sublineages exist. In individual isolates various insertions and deletions have been identified, with unknown impact on viral replication and pathogenicity. In order to assess whether different genetic features of EBLV-1 isolates correlate with phenotypic changes, different EBLV-1 variants were compared for pathogenicity in the mouse model. Groups of three mice were infected intracranially (i...
June 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28622424/migration-of-the-distal-catheter-of-the-ventriculoperitoneal-shunt-in-hydrocephalus-a-comprehensive-analytical-review-from-an-anatomical-perspective
#2
REVIEW
Mohammed Z Allouh, Mohammed M Al Barbarawi, Hasan A Asfour, Raed S Said
There have been many reports on migration of the distal catheter of the ventriculoperitoneal shunt (VPS) since this phenomenon was recognized 50 years ago. However, there have been no attempts to analyze its different patterns or to assess these patterns in terms of potential risk to patients. We comprehensively reviewed all reports of distal VPS catheter migration indexed in PubMed and identified three different anatomical patterns of migration based on catheter extension and organs involved: (1) internal, when the catheter invades any viscus inside the thoracic, abdominal, or pelvic cavity; (2) external, when the catheter penetrates through the body wall either incompletely (subcutaneously) or completely (outside the body); and (3) compound, when the catheter penetrates a hollow viscus and protrudes through a pre-existing anatomical orifice...
June 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28616823/population-pharmacokinetics-of-combined-intravenous-and-local-intrathecal-administration-of-meropenem-in-aneurysm-patients-with-suspected-intracranial-infections-after-craniotomy
#3
Xingang Li, Shusen Sun, Qiang Wang, Zhigang Zhao
BACKGROUND AND OBJECTIVE: For patients with intracranial infection, local intrathecal administration of meropenem may be a useful method to obtain a sufficient drug concentration in the cerebral spinal fluid (CSF). However, a large inter-individual variability may pose treatment efficacy at risk. This study aimed to identify factors affecting drug concentration in the CSF using population pharmacokinetics method. METHODS: After craniotomy, aneurysm patients with an indwelling lumbar cistern drainage tube who received a combined intravenous and intrathecal administration of meropenem for the treatment of suspected intracranial infection were enrolled...
June 14, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28614982/intraventricular-administration-of-tigecycline-for-the-treatment-of-multidrug-resistant-bacterial-meningitis-after-craniotomy-a-case-report
#4
Yuanxing Wu, Kai Chen, Jingwei Zhao, Qiang Wang, Jianxin Zhou
BACKGROUND: Intracranial infections, especially multidrug-resistant (MDR) bacterial meningitis, are one of the most severe complications after craniotomy and may greatly impact patient outcomes. CASE PRESENTATION: We report a case of severe MDR Klebsiella pneumonia meningitis after craniotomy that was treated with three different dosages of tigecycline (Pfizer, New York, NY, U.S.A.)via a combined intravenous (IV) and intracerebroventricular (ICV) administration...
June 14, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28614102/intracranial-complications-of-pediatric-sinusitis
#5
Alexandria J Wiersma, Tien Vu
"Headache and fever" is a common presentation to the urgent care and emergency department setting and can have many etiologies. We present a case of a 10-year-old girl who presented with headache and fever and was found to have intracranial extension of sinusitis despite lack of typical sinus or chronic upper respiratory tract infection symptoms. This case illustrates the need in the emergency department or urgent care to keep a broad differential diagnosis for pediatric headache, especially when initial interventions are unsuccessful...
June 13, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28611838/endovascular-embolization-of-intracranial-infectious-aneurysms-in-patients-undergoing-open-heart-surgery-using-n-butyl-cyanoacrylate
#6
Esteban Cheng-Ching, Seby John, Mark Bain, Gabor Toth, Thomas Masaryk, Ferdinand Hui, Muhammad Shazam Hussain
INTRODUCTION: Mycotic aneurysms are a serious complication of infective endocarditis with increased risk of intracranial hemorrhage. Patients undergoing open heart surgery for valve repair or replacement are exposed to anticoagulants, increasing the risk of aneurysm bleeding. These patients may require endovascular or surgical aneurysm treatment prior to heart surgery, but data on this approach are scarce. METHODS: Retrospective review of consecutive patients with infectious endocarditis and mycotic aneurysms treated endovascularly with Trufill n-butyl cyanoacrylate (n-BCA) at the Cleveland Clinic between January 2013 and December 2015...
March 2017: Interventional Neurology
https://www.readbyqxmd.com/read/28606302/-brain-abscesses-caused-by-nocardia-farcinica-in-a-kidney-transplanted-man
#7
Michaela Tinggaard, Kristian Bagge
Nocardiosis is primarily an opportunistic infection caused by aerobic Gram-positive bacteria of the genus Nocardia. In this case report we describe a male patient who previously received a kidney transplant and was admitted to hospital with chills, headache and pain in the neck and left eye, tremor and coordination problems. A magnetic resonance scan of the brain showed multiple abscesses, and blood culture was positive for Nocardia farcinica. Nocardiosis of the central nervous system is a rare, but serious differential diagnosis in immunosuppressed patients with signs of high intracranial pressure...
June 5, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28599004/extraparenchymal-neurocysticercosis-demographic-clinicoradiological-and-inflammatory-features
#8
Mariana Marcin Sierra, Mariana Arroyo, May Cadena Torres, Nancy Ramírez Cruz, Fernando García Hernández, Diana Taboada, Ángeles Galicia Martínez, Tzipe Govezensky, Edda Sciutto, Andrea Toledo, Agnès Fleury
BACKGROUND: Extraparenchymal neurocysticercosis (ExPNCC), an infection caused by Taenia solium cysticerci that mainly occurs in the ventricular compartment (Ve) or the basal subarachnoid space (SAb), is more severe but less frequent and much less studied than parenchymal neurocysticercosis (ParNCC). Demographic, clinical, radiological, and lumbar cerebrospinal fluid features of patients affected by ExPNCC are herein described and compared with those of ParNCC patients. METHODOLOGY AND PRINCIPAL FINDINGS: 429 patients with a confirmed diagnosis of neurocysticercosis, attending the Instituto Nacional de Neurología y Neurocirugía, a tertiary reference center in Mexico City, from 2000 through 2014, were included...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28597698/cavernous-sinus-fungal-infection-a-rare-case
#9
Boon Han Kevin Ng, Giat Seng Kho, Sze Kiat Sim, Donald Ngian San Liew, Ing Ping Tang
Intracranial fungal infection of the cavernous sinus is a condition that usually affects immunocompromised individuals and is rarely seen in immunocompetent individuals. It is a potentially life threatening condition which requires prompt treatment. Here we present a case of an immunocompetent patient with a fungal infection of the cavernous sinus.
June 9, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28593892/neonatal-hypoglycemia-risk-factors-and-outcomes
#10
Orhideja Stomnaroska, Elizabeta Petkovska, Snezana Jancevska, Dragan Danilovski
BACKGROUND AND AIMS: Severe neonatal hypoglycemia (HG) leads to neurologic damage, mental retardation, epilepsy, personality disorders, impaired cardiac performance and muscle weakness. We aimed to assess the clinical characteristics of children with hypoglycemia in a random population of newborns. PATIENTS, METHODS AND RESULTS: We investigated 84 patients (M:F=35:48) born at the University Clinic for Gynecology and Obstetrics in Skopje (hospitalized in the NICU) who were found to have hypoglycemia...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28593627/efficacy-and-safety-of-using-n-butyl-cyanoacrylate-in-fixation-of-cranial-following-trauma-and-other-pathologies
#11
Ahmed Sultan, Abbas Mohamed
Skull Bone fixation following different cranial surgeries is essential and should be rigid, simple and cheap. We describe our technique of cranial fixation using the adhesive cyanoacrylates. MATERIALS AND METHODS: At the end of cranial and intracranial surgeries the craniotomy flap and bone pieces are returned, realigned and fixed using Histoacryl® (N-Butyl Cyanoacrylate) glue. The glue is applied all around the flap in 360 degrees fashion. RESULT: The adhesive material was used in 24 cases after different surgeries involving the calvaria of the skull...
April 30, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28593066/sequence-analysis-of-long-term-readmissions-among-high-impact-users-of-cerebrovascular-patients
#12
Ahsan Rao, Alex Bottle, Ara Darzi, Paul Aylin
OBJECTIVE: Understanding the chronological order of the causes of readmissions may help us assess any repeated chain of events among high-impact users, those with high readmission rate. We aim to perform sequence analysis of administrative data to identify distinct sequences of emergency readmissions among the high-impact users. METHODS: A retrospective cohort of all cerebrovascular patients identified through national administrative data and followed for 4 years...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28592753/recent-surgical-results-for-active-endocarditis-complicated-with-perivalvular-abscess
#13
Daisuke Yoshioka, Koichi Toda, Jun-Ya Yokoyama, Ryohei Matsuura, Shigeru Miyagawa, Yukitoshi Shirakawa, Toshiki Takahashi, Taichi Sakaguchi, Hirotsugu Fukuda, Yoshiki Sawa
BACKGROUND: Surgical treatment for endocarditis patients with a perivalvular abscess is still challenging.Methods and Results:From 2009 to 2016, 470 patients underwent surgery for active endocarditis at 11 hospitals. Of these, 226 patients underwent aortic valve surgery. We compared the clinical results of 162 patients without a perivalvular abscess, 37 patients who required patch reconstruction of the aortic annulus (PR group) and 27 who underwent aortic root replacement (ARR group)...
June 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28591055/stereoelectroencephalography-based-on-the-leksell-stereotactic-frame-and-neurotech-operation-planning-software
#14
Guangming Zhang, Guoqiang Chen, Dawei Meng, Yanwu Liu, Jianwei Chen, Lanmei Shu, Wenbo Liu
This study aimed to introduce a new stereoelectroencephalography (SEEG) system based on Leksell stereotactic frame (L-SEEG) as well as Neurotech operation planning software, and to investigate its safety, applicability, and reliability.L-SEEG, without the help of navigation, includes SEEG operation planning software (Neurotech), Leksell stereotactic frame, and corresponding surgical instruments. Neurotech operation planning software can be used to display three-dimensional images of the cortex and cortical vessels and to plan the intracranial electrode implantation...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28589319/the-transotic-approach-for-vestibular-schwannoma-indications-and-results
#15
Yin Xia, Wenyang Zhang, Yi Li, Xiaobo Ma, Qiang Liu, Jinghua Shi
To analyze retrospectively the indications and the results obtained with the transotic approach in a series of patients with vestibular schwannoma. The study included 36 patients from 2007 to 2013 with a vestibular schwannoma that was removed with a transotic approach. All patients underwent preoperative pure tone audiometry, evaluation of facial function and CT and MR imaging. All patients having (1) a hearing loss of more than 50 dB, (2) an average tumor size of 2.7 cm (range 0.5-5.0 cm) and (3) signs of a contracted mastoid (high jugular bulb, anteriorly located sigmoid sinus, low middle cranial fossa, or reduced pneumatization) were selected...
June 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28589250/histopathological-and-bacteriological-analysis-of-thrombus-material-extracted-during-mechanical-thrombectomy-in-acute-stroke-patients
#16
Francisco Hernández-Fernández, Laura Rojas-Bartolomé, Jorge García-García, Óscar Ayo-Martín, Juan David Molina-Nuevo, Rosa Angélica Barbella-Aponte, Gemma Serrano-Heras, Enrique Juliá-Molla, María José Pedrosa-Jiménez, Tomás Segura
PURPOSE: Management of stroke secondary to septic emboli (SE) remains challenging, due to both the lack of specific recommendations and the gravity of the underlying pathology.The aim of this study is to describe the presence of SE in a series of mechanical thrombectomies (MT), analyzing technical complexity and outcomes with respect to the patients by means of histological analysis and microbiological study of the clot. METHODS: All the retrieved clots were studied under an established protocol, including histopathological and bacteriological study with hematoxylin-eosin, Gram and Gomori trichrome staining...
June 6, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28589072/pediatric-intrafalcine-empyema-from-a-sinogenic-origin-a-case-report
#17
Kyle Mueller, John Myseros
Sinusitis and otitis are common within the pediatric population. If left untreated, these can extend intracranially and lead to the development of infections in the various intracranial compartments resulting in a high rate of morbidity and mortality. We report the first case of an intrafalcine empyema, absent subdural purulence, in a patient with the likely spread from a sinogenic origin. This case illustrates the novelty of this as a pathological entity as well as the surgical considerations for intrafalcine purulence in the absence of expected subdural collections...
May 4, 2017: Curēus
https://www.readbyqxmd.com/read/28583742/visual-and-motor-deficits-in-grown-up-mice-with-congenital-zika-virus-infection
#18
Liyuan Cui, Peng Zou, Er Chen, Hao Yao, Hao Zheng, Qian Wang, Jing-Ning Zhu, Shibo Jiang, Lu Lu, Jiayi Zhang
Human infants with congenital Zika virus (ZIKV) infection exhibit a range of symptoms including microcephaly, intracranial calcifications, macular atrophy and arthrogryposis. More importantly, prognosis data have lagged far behind the recent outbreak of ZIKV in 2015. In this work, we allow congenitally ZIKV-infected mice to grow into puberty. These mice exhibited motor incoordination and visual dysfunctions, which can be accounted by anatomical defects in the retina and cerebellar cortex. In contrary, anxiety level of the ZIKV-infected mice is normal...
April 24, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28576515/a-case-report-of-cavernous-sinus-thrombosis-after-trauma
#19
Karen Y Choi, Christina J Yang
Cavernous sinus thrombosis is a rare but well-documented complication of sinus disease, propagated by intracranial spread of infection via valveless veins of the midface, with facial cellulitis as an uncommon source of infection. We present a case of significant intracranial thromboses secondary to nasal dorsal abscess after trauma that was successfully treated with bedside drainage of the abscess in addition to broad-spectrum antibiotics, anticoagulation, and steroids, and remains asymptomatic with seven months follow-up...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28573184/a-comparative-study-of-replication-incompetent-and-competent-adenoviral-therapy-mediated-immune-response-in-a-murine-glioma-model
#20
Julius W Kim, Jason Miska, Jacob S Young, Aida Rashidi, J Robert Kane, Wojciech K Panek, Deepak Kanojia, Yu Han, Irina V Balyasnikova, Maciej S Lesniak
Oncolytic virotherapy is a treatment approach with increasing clinical relevance, as indicated by the marked survival benefit seen in animal models and its current exploration in human patients with cancer. The use of an adenovirus vector for this therapeutic modality is common, has significant clinical benefit in animals, and its efficacy has recently been linked to an anti-tumor immune response that occurs following tumor antigen presentation. Here, we analyzed the adaptive immune system's response following viral infection by comparing replication-incompetent and replication-competent adenoviral vectors...
June 16, 2017: Molecular Therapy Oncolytics
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