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Calciphylaxis

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https://www.readbyqxmd.com/read/28638953/-chronic-leg-ulcers
#1
REVIEW
J Dissemond
Chronic wounds often manifest as ulcers on the lower legs. The main causes of chronic leg ulcers are chronic venous insufficiency and/or peripheral arterial occlusive disease in approximately 80% of all patients. However, there are also numerous other potentially relevant factors which can cause or almost impede the healing of chronic leg ulcers. Therefore, disease such as vasculitis, livedo vasculopathy, pyoderma gangrenosum, necrobiosis lipoidica, Martorell hypertensive leg ulcer, calciphylaxis, infectious diseases, neoplasms, drugs, cutaneous artefacts and genetic defects are exemplarily presented...
June 21, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28603903/a-systematic-review-of-sodium-thiosulfate-in-treating-calciphylaxis-in-chronic-kidney-disease-patients
#2
Ting Peng, Ling Zhuo, Ying Wang, Min Jun, Guisen Li, Li Wang, Daqing Hong
BACKGROUND: Calciphylaxis is a severe complication of advanced chronic kidney disease (CKD). Sodium thiosulphate (STS), an antioxidant and calcium chelating agent, has been used for the treatment of calciphylaxis. However, its efficacy and safety have not been systematically analysed and evaluated. METHODS: MEDLINE, EMBASE, and the Cochrane Library database were systematically searched for case report or cases series on use of STS for calciphylaxis published between July 1974 and October 2016...
June 11, 2017: Nephrology
https://www.readbyqxmd.com/read/28601542/the-signs-aligned-nonuremic-calciphylaxis
#3
Owen N Kramer, Benjamin C Garden, Igor Altman, Marylee Braniecki, Iris K Aronson
No abstract text is available yet for this article.
June 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28589153/calciphylaxis-in-the-setting-of-alcoholic-cirrhosis-case-report-and-literature-review
#4
Natasha Shah, Hafiz Muhammad Sharjeel Arshad, Yanxia Li, Rogelio Silva
Calciphylaxis can be a severe life-threatening dermatologic disease that is a known complication associated with end-stage renal disease. However, multiple non-uremic etiologies that are not yet well studied can cause calciphylaxis. We report a rare care of a 40-year-old female with history of alcoholic cirrhosis without any evidence of renal dysfunction who presents with calciphylaxis.
April 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28580642/underreported-use-of-palliative-care-and-patient-reported-outcome-measures-to-address-reduced-quality-of-life-in-calciphylaxis-patients-a-systematic-review
#5
REVIEW
C A Riemer, R A El-Azhary, K L Wu, J J Strand, J S Lehman
Calciphylaxis is associated with significant morbidity and mortality. Palliative care (PC) is a subspecialty that treats the pain and stress of serious illness. We performed a systematic review to assess whether quality of life (QoL) indices and the role of palliative care have been studied in calciphylaxis patients. We hypothesize PC services are underutilized to address reduced QoL in calciphylaxis. Several databases were searched from inception to October 2016 according to modified PRISMA criteria. We searched for papers about calciphylaxis that mentioned the symptoms and supportive needs of patients, QoL or outcome measures to report symptom severity, and the involvement of PC...
June 5, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28553189/the-role-of-bone-scintigraphy-with-single-photon-emission-computed-tomography-computed-tomography-in-the-diagnosis-and-evaluation-of-calciphylaxis
#6
Patrick Martineau, Matthieu Pelletier-Galarneau, Sadri Bazarjani
Calciphylaxis, also known as calcific uremic arteriolopathy, is an uncommon disease, typically found in patients with the end-stage renal disease. Pathophysiological features include small vessel vasculopathy with mural calcification, fibrosis, and thrombosis. The clinical presentation varies but often consists of the necrosis of skin and subcutaneous tissues, with or without visceral organ involvement due to small vessel vasculopathy. This condition has a significant morbidity and mortality, making accurate diagnosis imperative...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28529162/cirrhosis-presenting-as-cutaneous-calciphylaxis
#7
Connie R Shi, Molly Plovanich, Susan Burgin
No abstract text is available yet for this article.
May 18, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28522774/acenocoumarol-as-a-risk-factor-for-calciphylaxis-a-feature-clinicians-should-be-aware-of
#8
E F E Wenstedt, C J Huysentruyt, C J A M Konings
In contrast with uraemic calciphylaxis in end-stage renal disease, causes of and risk factors for non-uraemic calciphylaxis are relatively unknown to clinicians and have yet to become fully established. This report describes a case of non-uraemic calciphylaxis, in which the use of acenocoumarol might have been a risk factor. It is important to raise awareness about this association among clinicians, as vitamin K antagonists have to be stopped for an optimal treatment of this severe condition.
May 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28507910/penile-calciphylaxis-the-use-of-radiological-investigations-in-the-management-of-a-rare-and-challenging-condition
#9
Rebecca A Campbell, Laith M Alzweri, Nikolai A Sopko, Katarzyna J Macura, Arthur L Burnett
Penile calciphylaxis is a rare phenomenon of penile necrosis observed in patients with hemodialysis-dependent end-stage renal failure. Multiple treatments have been proposed including conservative management, surgical debridement and penectomy; yet, the prognosis remains extremely poor. Here, we describe a patient with protracted resolution of dry gangrene of the glans, which failed conservative management of wound care and pain management. Radiological studies revealed extensive calcification of abdominal aorta and branching vessels including the penile arteries...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28506812/a-33year-old-woman-with-calciphylaxis-diabetic-kidney-disease-and-abdominal-pain
#10
Denise Sanchez, Anh Phan, Emil Lesho
No abstract text is available yet for this article.
May 12, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28478757/-sodium-thiosulfate-for-the-treatment-of-acenocumarol-induced-calciphylaxis-in-a-patient-with-preserved-kidney-function
#11
Elena Mateos Egido, Attenya Álamo Medina, Ana Cristina Ródenas Gálvez, Marina Lombardero Pin, Alicia Díez Del Pino
No abstract text is available yet for this article.
May 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28470091/acute-cutaneous-necrosis-a-guide-to-early-diagnosis-and-treatment
#12
Karen Karimi, Ashika Odhav, Ramya Kollipara, Jesse Fike, Carol Stanford, John C Hall
Acute cutaneous necrosis is characterised by a wide range of aetiologies and is associated with significant morbidity and mortality, warranting complex considerations in management. Early recognition is imperative in diagnosis and management of sudden gangrenous changes in the skin. This review discusses major causes of cutaneous necrosis, examines the need for early assessment, and integrates techniques related to diagnosis and management. The literature, available via PubMed, on acute cutaneous necrotic syndromes was reviewed to summarise causes and synthesise appropriate treatment strategies to create a clinician's guide in the early diagnosis and management of acute cutaneous necrosis...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28436018/early-clinical-presentations-and-progression-of-calciphylaxis
#13
Toshi Ghosh, Daniel S Winchester, Mark D P Davis, Rokea El-Azhary, Nneka I Comfere
BACKGROUND: Untreated calciphylaxis is a fatal disease of intra- and extravascular calcification, most commonly presenting in end-stage renal disease (ESRD) patients. While early identification is critical for timely treatment, early-stage clinical and histopathological descriptions have not, to our knowledge, been elucidated. As early clinical recognition is essential to prompt definitive histopathological diagnosis, this study describes a range of clinical and histopathological manifestations of early-stage calciphylaxis...
April 23, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28431568/a-case-report-of-severe-calciphylaxis-suggested-approach-for-diagnosis-and-treatment
#14
Margret Patecki, Gabriele Lehmann, Jan Hinrich Bräsen, Jessica Schmitz, Anna Bertram, Lars Daniel Berthold, Hermann Haller, Wilfried Gwinner
BACKGROUND: Calciphylaxis is a serious complication in patients with chronic kidney disease associated mineral and bone disorder. It can occur in conditions with low and high bone turnover. So far, there are no definite diagnostic and therapeutic guidelines which may prevent the devastating outcome in many calciphylaxis patients. We report a case which clearly illustrates that knowledge of the underlying bone disorder is essential for a directed treatment. Based on this experience we discuss a systematic diagnostic and therapeutic approach in patients with calciphylaxis...
April 21, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28413385/calciphylaxis-presenting-with-various-symptoms-a-case-report
#15
Shinpei Miura, Kazuhiro Takahashi, Toshihide Akasaka
Calciphylaxis causes ischemia in multiple organs and skin ulcers owing to progressive calcification in small and medial arteries. It has a poor prognosis and often occurs in patients with hyperparathyroidism associated with end-stage renal failure and those undergoing hemodialysis. Here, we present a case of calciphylaxis associated with a wide range of symptoms, including lower thigh skin ulcers, a rectovaginal fistula, and femoral neck fracture. The patient underwent multiple treatments. However, she eventually died of cardiac failure...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28390776/calciphylaxis-beyond-ckd-mbd
#16
María Fernández, Enrique Morales, Eduardo Gutierrez, Natalia Polanco, Eduardo Hernández, Eva Mérida, Manuel Praga
INTRODUCTION: Calcific uraemic arteriolopathy (CUA), also called calciphylaxis, is a rare but potentially fatal vascular disorder that almost exclusively affects patients with chronic renal failure. The objective of this study was to analyse various risk factors for developing CUA and its subsequent clinical course according to the treatment received. MATERIALS AND METHODS: A retrospective study that included patients diagnosed with CUA from December 1999 to December 2015...
April 5, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28380267/fractures-in-calciphylaxis-patients-following-intravenous-sodium-thiosulfate-therapy
#17
Allison S Dobry, Lauren N Ko, Daniela Kroshinsky
Calciphylaxis is a highly fatal syndrome of small vessel calcification that results in skin ischemia and necrosis.[1] Affected patients present with extremely painful, violaceous skin lesions that progress to non-healing ulcers, and can be complicated by superimposed infections and sepsis.[2] The mortality rate from calciphylaxis is estimated at 60-80%.[2, 3] Sodium thiosulfate (STS), an increasingly popular treatment for calciphylaxis, is theorized to work through vasodilation, antioxidation, and calcium chelation...
April 5, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28375870/calciphylaxis
#18
Sagar U Nigwekar
PURPOSE OF REVIEW: Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calciphylaxis. RECENT FINDINGS: The most recent estimate places the incidence of calciphylaxis at 3.5 new cases/1000 patient-years among the patients with ESRD on chronic hemodialysis...
July 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28336239/penile-gangrene-by-calciphylaxis-an-unusual-clinical-presentation-in-a-patient-with-diabetic-nephropathy-on-hemodialysis
#19
Guevar Maselli, Marco Cordari, Francesco Catanzariti, Gaetano Donatelli, Lucio Dell'Atti, Andrea Benedetto Galosi
No abstract text is available yet for this article.
March 20, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28326673/benefits-of-intralesional-injections-of-sodium-thiosulfate-in-the-treatment-of-calciphylaxis
#20
Kirsi Isoherranen, Laura Bouchard, Nicolas Kluger
Calciphylaxis (CPX) is a rare calcifying thrombotic vasculopathy responsible for painful necrotic ulcers, with a high mortality rate, and its management is often difficult. Recently, intravenous infusions of sodium thiosulfate (STS) have shown efficacy. The aim of this study was to assess the efficacy of intralesional STS (IL STS) in four patients. Our aim was to assess the efficacy of IL STS in a prospective mono-centric open study that included four patients with a biopsy-proven cutaneous CPX. Four women (55-84 years old, mean age: 71·2 years) with a uremic (n = 1) or non-uremic CPX (n = 3) and primary hyperparathyroidism induced by teriparatide or after the initiation of oral anti-vitamin K were treated by IL STS (250 mg/ml)...
March 21, 2017: International Wound Journal
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