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Calciphylaxis

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https://www.readbyqxmd.com/read/27900978/penile-calcific-uremic-arteriolopathy-occurring-postparathyroidectomy-in-a-hemodialysis-patient
#1
Salah Omar Bashir, Mahmoud A Aamer, Hayder A Omer, Mohamed D Morsy
Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare condition most frequently seen in patients with advanced chronic kidney disease. The clinical picture is characterized by painful skin lesions and ulcerations. The underlying pathology is medial calcification and intimal proliferation with microthrombi of small arteries. CUA is commonly associated with secondary hyperparathyroidism and high serum calcium and phosphate products. This article reports an atypical case where CUA developed after parathyroidectomy and in the course of treatment of hungry bone syndrome...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27853075/minimal-change-nephrotic-syndrome-sequentially-complicated-by-acute-kidney-injury-and-painful-skin-ulcers-due-to-calciphylaxis
#2
Ryuta Sato, Tetsu Akimoto, Toshimi Imai, Saki Nakagawa, Mari Okada, Atsushi Miki, Shinichi Takeda, Hisashi Yamamoto, Osamu Saito, Shigeaki Muto, Eiji Kusano, Daisuke Nagata
Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis. There seemed to be several contributing factors, including a disturbance of the patient's mineral metabolism and the systemic use of glucocorticoids and warfarin...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27851620/1986-calciphylaxis-as-a-contributor-to-refractory-hypotension
#3
Ashish Agrawal, Evan Werlin, Michelle Yu, Matthew Lin, Anne Donovan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27826606/resolution-of-calciphylaxis-after-urgent-kidney-transplantation-in-3-patients-with-end-stage-kidney-failure
#4
Espen Nordheim, Dag Olav Dahle, Ingrid Marie Syse, Anders Åsberg, Anna V Reisæter, Anders Hartmann
BACKGROUND: Calcific uremic arteriolopathy (CUA), also referred to as calciphylaxis, is a rare and serious complication of kidney failure with limited treatment options. Kidney transplantation (KTX) restores kidney function and is hence a potential treatment option for CUA. We present 3 patients who had their CUA lesions successfully healed after urgent KTX. METHODS: Data were retrospectively retrieved from hospital records at our national transplant center. RESULTS: All 3 patients had previously been kidney transplanted and had experienced graft loss and were in stage 5 kidney failure when CUA developed...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27822733/-cutaneous-manifestations-in-renal-diseases
#5
M Schmid-Simbeck, A Udvardi, B Volc-Platzer
In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Nonhealing wounds with superinfection and progression to sepsis are characteristic. Bullous lesions can be caused by disturbances in porphyrin metabolism. Nephrogenic systemic fibrosis is a disease which was first described in 2000...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27781116/case-report-of-a-patient-undergoing-peritoneal-dialysis-with-encapsulating-peritoneal-sclerosis-superimposed-with-calciphylaxis
#6
Jun Li Tsai, Ming Ju Wu, Cheng Hsu Chen, Shang Feng Tsai
INTRODUCTION: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials. CASE PRESENTATION: Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. We also provide a comprehensive discussion about the association between EPS and calciphylaxis. Moreover, although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production, it may worsen the calciphylaxis due to a hypercoagulable state...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27712638/calciphylaxis-a-disease-of-pannicular-thrombosis
#7
Rokea A El-Azhary, Michelle T Patzelt, Robert D McBane, Amy L Weaver, Robert C Albright, Alina D Bridges, Paul L Claus, Mark D P Davis, John J Dillon, Ziad M El-Zoghby, LaTonya J Hickson, Rajiv Kumar, Kathleen A M McCarthy-Fruin, Marian T McEvoy, Mark R Pittelkow, David A Wetter, Amy W Williams, James T McCarthy
OBJECTIVE: To identify coagulation risk factors in patients with calciphylaxis and the relationship between anticoagulation use and overall survival. PATIENTS AND METHODS: Study subjects were 101 patients with calciphylaxis seen at Mayo Clinic from 1999 to September 2014. Data including thrombophilia profiles were extracted from the medical records of each patient. Survival status was determined using patient registration data and the Social Security Death Index...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27712637/survival-risk-factors-and-effect-of-treatment-in-101-patients-with-calciphylaxis
#8
James T McCarthy, Rokea A El-Azhary, Michelle T Patzelt, Amy L Weaver, Robert C Albright, Alina D Bridges, Paul L Claus, Mark D P Davis, John J Dillon, Ziad M El-Zoghby, LaTonya J Hickson, Rajiv Kumar, Robert D McBane, Kathleen A M McCarthy-Fruin, Marian T McEvoy, Mark R Pittelkow, David A Wetter, Amy W Williams
OBJECTIVE: To report on the survival and the associations of treatments upon survival of patients with calciphylaxis seen at a single center. PATIENTS AND METHODS: Using the International Classification of Diseases, Ninth Revision diagnosis code of 275.49 and the keyword "calciphylaxis" in the dismissal narrative, we retrospectively identified 101 patients with calciphylaxis seen at our institution between January 1, 1999, through September 20, 2014, using a predefined, consensus-developed classification scheme...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27698566/calciphylaxis-in-peritoneal-dialysis-patients-a-single-center-cohort-study
#9
Yanchen Zhang, Kristin M Corapi, Maria Luongo, Ravi Thadhani, Sagar U Nigwekar
BACKGROUND: Calciphylaxis is a rare but devastating condition in end-stage renal disease (ESRD) patients. Most research in the field of calciphylaxis is focused on hemodialysis (HD) patients; however, data on calciphylaxis incidence, risk factors, and mortality in peritoneal dialysis (PD) patients are limited. METHODS: In this cohort study, we examined data from adult patients who initiated PD for ESRD management at our institute's PD unit from January 2001 to December 2015...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/27687504/letter-to-the-editor-submitted-in-response-to-sodium-thiosulfate-as-a-treatment-for-calciphylaxis-a-case-series
#10
Craig Sherman
No abstract text is available yet for this article.
August 10, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27686313/bilateral-optic-neuropathy-acral-gangrene-and-visceral-ischaemia-as-a-rare-presentation-of-calciphylaxis-a-case-report
#11
Hatice Ferhan Komurcu, Emel Basar, Orhan Kucuksahin, Ebru Uz, Huban Sibel Orhun Yavuz, Omer Anlar
We report a case with calciphylaxis very rarely presenting with bilateral optic neuropathy, acral gangrene and visceral ischaemia. Bilateral papilloedaema was found in a 43 year-old female with chronic renal failure. Acral dry gangrene was observed. Pathological examination of her amputated thumb revealed calcification, thrombi, obstructive endovascular fibrotic areas in the walls of arteries. She was diagnosed with calciphylaxis. Bilateral optic neuropathy was defined secondary to calciphylaxis. Abdominal computerized tomography revealed prominent calcifications in mesenteric, spleen and renal arteries...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27666907/diagnosis-of-calciphylaxis-by-imaging-with-low-energy-x-rays-mammographic-technique
#12
Wilson Benny Paul, I Ramya, Renu George, Surekha Viggeswarpu
No abstract text is available yet for this article.
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27651467/the-efficacy-and-safety-of-sevelamer-and-lanthanum-versus-calcium-containing-and-iron-based-binders-in-treating-hyperphosphatemia-in-patients-with-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#13
Steven Habbous, Sebastian Przech, Rey Acedillo, Sisira Sarma, Amit X Garg, Janet Martin
BACKGROUND: It remains unclear which phosphate binders should be preferred for hyperphosphatemia management in chronic kidney disease (CKD). METHODS: We performed a systematic review and meta-analysis of randomized trials comparing sevelamer or lanthanum with other phosphate binders in CKD. RESULTS: Fifty-one trials (8829 patients) were reviewed. Compared with calcium-based binders, all-cause mortality was nonsignificantly lower with sevelamer {risk ratio [RR] 0...
September 20, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27646745/the-cutaneous-expression-of-vitamin-k-dependent-and-other-osteogenic-proteins-in-calciphylaxis-stratified-by-clinical-features-and-warfarin-use-a-case-control-study
#14
Frances Tian, Andrew T Patterson, Jonathan J Davick, Steven W Ing, Benjamin H Kaffenberger, Alejandro A Gru
No abstract text is available yet for this article.
October 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27643979/clinical-application-and-pharmacodynamic-monitoring-of-apixaban-in-a-patient-with-end-stage-renal-disease-requiring-chronic-hemodialysis
#15
Wesley D Kufel, Adam S Zayac, David F Lehmann, Christopher D Miller
Despite prescribing guidance, limited data exist to describe the use of apixaban in patients with end-stage renal disease (ESRD) requiring hemodialysis (HD). Current apixaban dosing recommendations for this patient population are based largely on a single-dose pharmacokinetic study of eight patients. We describe the clinical application and pharmacodynamic monitoring of apixaban in a 62-year-old 156-kg African-American woman with nonvalvular atrial fibrillation and ESRD requiring hemodialysis who developed calciphylaxis while receiving warfarin therapy...
September 19, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27622522/calciphylaxis-and-martorell-hypertensive-ischemic-leg-ulcer-same-pattern-one-pathophysiology
#16
Jürg Hafner
This review presents a closer look at four diseases which are probably closely related to one another pathophysiologically: (a) calciphylaxis (distal pattern); (b) calciphylaxis (proximal pattern); (c) Martorell hypertensive ischemic leg ulcer; (d) calciphylaxis with normal renal and parathyroid function (synonym: eutrophication). The four diseases have largely the same risk factors: (1) arterial hypertension, (2) diabetes mellitus (types 1 and 2), (3) secondary or tertiary hyperparathyroidism (in end-stage kidney disease) and (4) oral anticoagulation with vitamin K antagonists...
September 14, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27621504/sodium-thiosulfate-calciphylaxis
#17
EDITORIAL
Joyce A Generali, Dennis J Cada
This Hospital Pharmacy feature is extracted from Off-Label Drug Facts, a publication available from Wolters Kluwer Health. Off-Label Drug Facts is a practitioner-oriented resource for information about specific drug uses that are unapproved by the US Food and Drug Administration. This new guide to the literature enables the health care professional or clinician to quickly identify published studies on off-label uses and determine if a specific use is rational in a patient care scenario. References direct the reader to the full literature for more comprehensive information before patient care decisions are made...
November 2015: Hospital Pharmacy
https://www.readbyqxmd.com/read/27566435/case-report-of-calciphylaxis-secondary-to-calcium-and-vitamin-d3-supplementation
#18
Eoin R Storan, Susan M O'Gorman, Annette Murphy, Mary Laing
BACKGROUND: Calciphylaxis is a rare disorder that is very unusual outside the setting of end-stage kidney disease. CASE SUMMARY: A 64-year-old woman with normal renal function presented with painful leg ulcers. She had previously received 300 000 IU of vitamin D3 followed by daily calcium and vitamin D3 supplementation. A skin biopsy was consistent with calciphylaxis, and she was treated with sodium thiosulphate infusions and wound debridement. CONCLUSION: Calcium and vitamin D3 supplements are widely prescribed...
August 26, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27507694/calciphylaxis-of-the-breast-a-rare-metabolic-complication-of-kidney-disease
#19
Abhilash Koratala, Abutaleb A Ejaz, Rajesh Mohandas
No abstract text is available yet for this article.
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27505874/advanced-stage-calciphylaxis-think-before-you-punch
#20
Arsha Sreedhar, Hina A Sheikh, Charles J Scagliotti, Ranjit Nair
No abstract text is available yet for this article.
August 2016: Cleveland Clinic Journal of Medicine
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