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https://www.readbyqxmd.com/read/28231563/hypoxia-pathway-mutations-in-pheochromocytomas-and-paragangliomas
#1
Diana Amorim-Pires, Joana Peixoto, Jorge Lima
Pheochromocytomas (PCC) and sympathetic paragangliomas (PGL) are rare neuroendocrine tumors, which derive from chromaffin cells occurring in the adrenal medulla and extra-adrenal sympathetic paraganglia. PCC and PGL are often benign, catecholamine-producing tumors, responsible for a myriad of symptoms that may be potentially hazardous to the patient. In contrast, nonsecreting parasympathetic PGL, derived from chief cells, develop mainly in the head and neck region. Although PCC/PGL are more commonly sporadic tumors, germline mutations are present in up to 40% of the patients, ranking these tumors among those with the highest degree of heritability...
February 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28228335/alterations-in-cardiac-autonomic-control-in-spinal-cord-injury
#2
Fin Biering-Sørensen, Tor Biering-Sørensen, Nan Liu, Lasse Malmqvist, Jill Maria Wecht, Andrei Krassioukov
A spinal cord injury (SCI) interferes with the autonomic nervous system (ANS). The effect on the cardiovascular system will depend on the extent of damage to the spinal/central component of ANS. The cardiac changes are caused by loss of supraspinal sympathetic control and relatively increased parasympathetic cardiac control. Decreases in sympathetic activity result in heart rate and the arterial blood pressure changes, and may cause arrhythmias, in particular bradycardia, with the risk of cardiac arrest in those with cervical or high thoracic injuries...
February 15, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28227818/detecting-divisions-of-the-autonomic-nervous-system-using-wearables
#3
Annamalai Natarajan, Kevin S Xu, Brian Eriksson, Annamalai Natarajan, Kevin S Xu, Brian Eriksson, Kevin S Xu, Brian Eriksson, Annamalai Natarajan
The ability to assess a user's emotional reaction from biometrics has applications in personalization, recommendation, and enhancing user experiences, among other areas. Unfortunately, understanding the connection between biometric signals and user reactions has previously focused on black box techniques that are opaque to the underlying physiology of the user. In this paper, we explore a novel user study connecting biometric reaction to external stimuli and changes in the user's autonomic nervous system. Specifically, we focus on two competing responses, namely the sympathetic and parasympathetic nervous system, and how differing activations are related to different user responses...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227138/assessment-of-autonomic-neurodevelopment-in-the-mouse-fetuses-by-using-fetal-electrocardiography
#4
Ahsan H Khandoker, Thuraia Al Khoori, Takuya Ito, Rika Sugibayashi, Yoshitaka Kimura, Ahsan H Khandoker, Thuraia Al Khoori, Takuya Ito, Rika Sugibayashi, Yoshitaka Kimura, Thuraia Al Khoori, Yoshitaka Kimura, Rika Sugibayashi, Takuya Ito, Ahsan H Khandoker
Fetal Electrocardiography (FECG) offers unique capabilities for assessment of beat-to-beat fetal heart rate (FHR) and fetal heart rate variability (FHRV), which are indirect markers of autonomic nervous system, its development. In this study the fetal ECG signals, FHR and FHRV are successfully recorded to assess the neurodevelopment in fetal mice in the second and third trimester from days 12.5 to 18.5 by using direct insertion of fetal ECG electrodes in the uterine. FHR increases from day 12.5 till 15.5 reaching a plateau and then shows a sudden increase on the day 18...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226651/comparison-of-pulse-rate-variability-and-heart-rate-variability-for-high-frequency-content-estimation
#5
R Logier, J De Jonckheere, A Dassonneville, M Jeanne, R Logier, J De Jonckheere, A Dassonneville, M Jeanne, A Dassonneville, J De Jonckheere, R Logier, M Jeanne
Heart Rate Variability (HRV) analysis can be of precious help in most of clinical situations because it is able to quantify the Autonomic Nervous System (ANS) activity. The HRV high frequency (HF) content, related to the parasympathetic tone, reflects the ANS response to an external stimulus responsible of pain, stress or various emotions. We have previously developed the Analgesia Nociception Index (ANI), based on HRV high frequency content estimation, which quantifies continuously the vagal tone in order to guide analgesic drug administration during general anesthesia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226650/disentanglement-of-sympathetic-and-parasympathetic-activity-by-instantaneous-analysis-of-human-heartbeat-dynamics
#6
Gaetano Valenza, Luca Citi, Riccardo Barbieri, Gaetano Valenza, Luca Citi, Riccardo Barbieri, Luca Citi, Riccardo Barbieri, Gaetano Valenza
Spectral analysis of heart rate variability (HRV) is one of the most effective techniques for the assessment of the influence of the autonomic nervous system (ANS) on the heartbeat. Despite its widespread use, it has been demonstrated that HRV subdivision in the low frequency (LF) and high frequency (HF) bands does not accurately reflect separate sympathetic and parasympathetic influences, respectively, mainly due to overlap of the two branches in the low frequencies. Here we propose two novel indices, namely the instantaneous sympathetic autonomic index (SAI) and parasympathetic autonomic index (PAI), that are able to separately assess the time-varying ANS synergic functions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226649/heart-rate-independent-qt-variability-component-can-detect-subclinical-cardiac-autonomic-neuropathy-in-diabetes
#7
Mohammad H Imam, Chandan K Karmakar, Ahsan H Khandoker, Herbert F Jelinek, M Palaniswami, Mohammad H Imam, Chandan K Karmakar, Ahsan H Khandoker, Herbert F Jelinek, M Palaniswami, Ahsan H Khandoker, Herbert F Jelinek, Chandan K Karmakar, Mohammad H Imam, M Palaniswami
Cardiac autonomic neuropathy (CAN) may lead to life threatening arrhythmia due to denervation of both the parasympathetic and sympathetic branches of autonomic nervous system innervating the heart. CAN is a frequently under diagnosed complication of diabetes, because a patient can have asymptomatic CAN for several years before it is clinically apparent. However, detection of CAN at the early or subclinical stage leads to more effective treatment outcomes. Cardiac autonomic reflex tests (CART) (i.e. Ewing test battery) are normally used for the detection and staging of CAN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226574/a-temperature-controlled-glove-with-non-invasive-arterial-pulse-sensing-for-active-neuro-vascular-assessment
#8
Andrew M Carek, Omer T Inan, Andrew M Carek, Omer T Inan, Andrew M Carek, Omer T Inan
A non-invasive, active neuro-vascular assessment system was developed using a modified temperature-controlled glove and feedback techniques. The glove incorporates local heating and cooling of the hand using multi-point skin temperature measurements as feedback, and thereby induces local and central mechanisms involved in thermoregulation. Electrocardiogram (ECG), photoplethysmogram (PPG) and non-invasive finger-cuff based blood pressure (BP) measurements were used to monitor electrophysiology and hemodynamic changes in response to temperature modulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226198/olanzapine-induced-early-cardiovascular-effects-are-mediated-by-the-biological-clock-and-prevented-by-melatonin
#9
Francisco Romo-Nava, Frederik N Buijs, Marcela Valdés-Tovar, Gloria Benítez-King, MariCarmen Basualdo, Mercedes Perusquía, Gerhard Heinze, Carolina Escobar, Ruud M Buijs
Second generation antipsychotics (SGA) are associated with adverse cardiometabolic side-effects contributing to premature mortality in patients. While mechanisms mediating these cardiometabolic side-effects remain poorly understood, three independent studies recently demonstrated that melatonin was protective against cardiometabolic risk in SGA-treated patients. Since one of the main target areas of circulating melatonin in the brain is the suprachiasmatic nucleus (SCN), we hypothesized that the SCN is involved in SGA-induced early cardiovascular effects in Wistar rats...
February 22, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28222576/may-a-unitary-autonomic-index-help-assess-autonomic-cardiac-regulation-in-elite-athletes-preliminary-observations-on-the-national-italian-olympic-committee-team
#10
Roberto Sala, Mara Malacarne, Fabio Tosi, Manuela Benzi, Nadia Solaro, Stefano Tamorri, Antonio Spataro, Massimo Pagani, Daniela Lucini
BACKGROUND: Long term endurance training, as occurring in elite athletes, is associated to cardiac neural remodeling in favor of cardioprotective vagal mechanisms, resulting in resting bradycardia and augmented contribution of cardiac parasympathetic nerve activity. Autonomic assessment can be performed by way of Heart Rate Variability. This technique however provides multiple indices, and there is not yet complete agreement on their specific significance. Purpose of the study was to assess whether a rank transformation and radar plot could provide a unitary autonomic index, capable to show a correlation between intensity of individual work and quality of autonomic regulation...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28221172/interventional-pulmonology-in-chronic-obstructive-pulmonary-disease
#11
Daniela Gompelmann, Nilab Sarmand, Felix J F Herth
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) and emphysema are widespread diseases associated with progressive dyspnea because of airflow limitation and hyperinflation. Fundamental therapeutic strategies consist of pulmonary rehabilitation, pharmacotherapy, long-term oxygen therapy, noninvasive ventilation, and surgical therapeutic approaches. RECENT FINDINGS: In the last 14 years, endoscopic therapeutic modalities emerged as a substantial part of severe COPD and emphysema treatment...
February 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28220146/horseback-riding-improves-the-ability-to-cause-the-appropriate-action-go-reaction-and-the-appropriate-self-control-no-go-reaction-in-children
#12
Nobuyo Ohtani, Kenji Kitagawa, Kinuyo Mikami, Kasumi Kitawaki, Junko Akiyama, Maho Fuchikami, Hidehiko Uchiyama, Mitsuaki Ohta
BACKGROUND: There are many obvious health benefits to riding, including developing a strong core and legs, but there are also many less obvious benefits, such as increased confidence and introspection. Few studies have addressed the effects of horseback riding on children and the mechanisms underlying how riding affects humans. We examined the effects of horseback riding on the ability to distinguish Go/No-go tasks and solve arithmetic problems in children. METHODS: The subjects were 34 boys and 72 girls, aged 10-12 years old, which were divided into three groups (horse riding, walking, and resting)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28215623/higher-locus-coeruleus-mri-contrast-is-associated-with-lower-parasympathetic-influence-over-heart-rate-variability
#13
Mara Mather, Hyun Joo Yoo, David V Clewett, Tae-Ho Lee, Steven G Greening, Allison Ponzio, Jungwon Min, Julian F Thayer
The locus coeruleus (LC) is a key node of the sympathetic nervous system and suppresses parasympathetic activity that would otherwise increase heart rate variability. In the current study, we examined whether LC-MRI contrast reflecting neuromelanin accumulation in the LC was associated with high-frequency heart rate variability (HF-HRV), a measure reflecting parasympathetic influences on the heart. Recent evidence indicates that neuromelanin, a byproduct of catchecholamine metabolism, accumulates in the LC through young and mid adulthood, suggesting that LC-MRI contrast may be a useful biomarker of individual differences in habitual LC activation...
February 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28215570/the-cardiac-electrophysiology-of-patients-with-spinal-cord-injury
#14
Michael Manogue, David S Hirsh, Michael Lloyd
Spinal cord injury (SCI) is a clinical syndrome encountered frequently in trauma centers and is accompanied by both acute and chronic heart rhythm abnormalities. The injury is characterized by sympathetic nervous system (SNS) impairment with preservation of parasympathetic output via the vagus nerve. Severe bradycardia in the form of life-threatening sinus arrest or complete heart block may be observed in the acute recovery phase. Therapy for arrhythmias in the acute phase includes atropine, intravenous chronotropes, methylxanthines for prevention of episodic bradycardia, and pacemaker implantation in severe cases...
February 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28215154/stress-and-salivary-glands
#15
Beáta Kerémi, Anita Beck, Tibor Károly Fábián, Gábor Fábián, Géza Szabó, Ákos Nagy, Gábor Varga
Salivary glands produce a bicarbonate-rich fluid containing digestive and protective proteins and other components to be delivered into the gastrointestinal tract. Its function is under strict control of the autonomic nervous system. Salivary electrolyte and fluid secretion is primarily controlled by parasympathetic activity, while protein secretion is primaily triggered by sympathetic stimulation. Stress activates the hypothalamic - pituitary - adrenal axis. The peripheral limb of this axis is the efferent sympathetic/adrenomedullary system...
February 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28211138/nocturnal-autonomic-nervous-system-activity-and-morning-proinflammatory-cytokines-in-young-adult-african-americans
#16
Kimberly A Bell, Ihori Kobayashi, Yuanxiu Chen, Thomas A Mellman
Compromised sleep and increased sympathetic nervous system (SNS) activity are implicated in the pathogenesis of, and disparities in, cardiovascular disease. Parasympathetic dominance during sleep may be important for cardiovascular health. Sleep and autonomic balance influence immune activity, which impacts atherogenesis. We evaluated relationships between autonomic balance during sleep and morning levels of the immune activating cytokines, C-reactive protein (CRP) and interleukin (IL)-6. Ninety-four (59 female) young adult African Americans without medical conditions and substance use disorders spent 2 consecutive nights in a clinical research unit for sleep recordings and blood drawing on awakening...
February 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28210905/hypermagnesemia-disturbances-in-rats-no-related-pentadecapeptide-bpc-157-abrogates-l-name-and-l-arginine-worsen
#17
Maria Medvidovic-Grubisic, Vasilije Stambolija, Danijela Kolenc, Jadranka Katancic, Tamara Murselovic, Ivna Plestina-Borjan, Sanja Strbe, Domagoj Drmic, Ivan Barisic, Aleksandra Sindic, Sven Seiwerth, Predrag Sikiric
AIM: Stable gastric pentadecapeptide BPC 157, administered before a high-dose magnesium injection in rats, might be a useful peptide therapy against magnesium toxicity and the magnesium-induced effect on cell depolarization. Moreover, this might be an NO-system-related effect. Previously, BPC 157 counteracts paralysis, arrhythmias and hyperkalaemia, extreme muscle weakness; parasympathetic and neuromuscular blockade; injured muscle healing and interacts with the NOS-blocker and NOS-substrate effects...
February 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28208852/alteration-of-heart-rate-variability-in-patients-of-depression
#18
Deepti Jangpangi, Sunita Mondal, Rajiv Bandhu, Dinesh Kataria, Asha Gandhi
INTRODUCTION: Altered cardiac autonomic functions in form of reduced Heart Rate Variability (HRV) have been found to be associated with increased cardiovascular morbidity and mortality in depressive patients. AIM: To investigate the relationship between HRV measures, which is a non-invasive marker of autonomic nervous system and depression. MATERIALS AND METHODS: The study included a convenient sample size of drug naive depressive patients (n=30) diagnosed on basis of ICD-10 and compared with age and gender matched healthy volunteers (n=30)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203208/changes-in-heart-rate-variability-recorded-in-natural-situation-with-t-shirt-integrated-sensors-and-level-of-observed-behavioral-excitation-a-pilot-study-of-patients-with-intellectual-disabilities-and-psychiatric-disorders
#19
Julie Palix, Michel Akselrod, Charly Cungi, Fabienne Giuliani, Jérôme Favrod
BACKGROUND: The present study investigates the possibilities of using heart rate variability (HRV) parameters as physiological markers that precede increase in observed behavioral excitation of intellectually disabled individuals. The ability to recognize or predict such patterns, especially in patients showing unpredictable reactions and language deficiencies, might be a major step forward in clinical research. METHOD: Thirteen volunteers with intellectual disabilities, who had suffered of at least one event of overt aggression in the preceding 3 months, participated to the study...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28199851/the-input-output-relationship-of-the-cholinergic-basal-forebrain
#20
Matthew R Gielow, Laszlo Zaborszky
Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and attention. They collectively innervate the entire cerebral cortex, differentially controlling acetylcholine efflux across different cortical areas and timescales. Such control might be achieved by differential inputs driving separable cholinergic outputs, although no input-output relationship on a brain-wide level has ever been demonstrated. Here, we identify input neurons to cholinergic cells projecting to specific cortical regions by infecting cholinergic axon terminals with a monosynaptically restricted viral tracer...
February 14, 2017: Cell Reports
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