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Pingping Jia, Weihang Chai
Genome instability gives rise to cancer. MLH1, commonly known for its important role in mismatch repair (MMR), DNA damage signaling and double-strand break (DSB) repair, safeguards genome stability. Recently we have reported a novel role of MLH1 in preventing aberrant formation of interstitial telomeric sequences (ITSs) at intra-chromosomal regions. Deficiency in MLH1, in particular its N-terminus, leads to an increase of ITSs. Here, we identify that the ATPase activity in the MLH1 N-terminal domain is important for suppressing the formation of ITSs...
March 7, 2018: DNA Repair
Rafael Sierra-Guzmán, Fernando Jiménez, Javier Abián-Vicén
BACKGROUND: Previous studies have reported the factors contributing to chronic ankle instability, which could lead to more effective treatments. However, factors such as the reflex response and ankle muscle strength have not been taken into account in previous investigations. METHODS: Fifty recreational athletes with chronic ankle instability and 55 healthy controls were recruited. Peroneal reaction time in response to sudden inversion, isokinetic evertor muscle strength and dynamic balance with the Star Excursion Balance Test and the Biodex Stability System were measured...
March 6, 2018: Clinical Biomechanics
Olivier Beauchet, Cyrille P Launay, Harmehr Sekhon, Jennifer Gautier, Julia Chabot, Elise J Levinoff, Gilles Allali
BACKGROUND: Assessment of changes in higher levels of gait control with aging is important to better understand age-related gait instability, with the perspective to improve the screening of individuals at risk for falls. The comparison between actual Timed Up and Go test (aTUG) and its imagined version (iTUG) is a simple clinical way to assess age-related changes in gait control. The modulations of iTUG performances by body positions and motor imagery (MI) strategies with normal aging have not been evaluated yet...
2018: PloS One
Javad Parvizi, Laurent Sedel, Michael J Dunbar
No abstract text is available yet for this article.
April 2018: Clinical Orthopaedics and related Research
Yong-Jun Xu, Hui Sheng, Tian-Wen Wu, Qing-Yue Bao, You Zheng, Yan-Min Zhang, Yu-Xiang Gong, Jian-Qiang Lu, Zhen-Dong You, Yang Xia, Xin Ni
Pregnant women at risk of preterm labor usually receive synthetic glucocorticoids (sGCs) to promote fetal lung development. Emerging evidence indicates that antenatal sGC increases the risk of affective disorders in offspring. Data from animal studies show that such disorders can be transmitted to the second generation. However, the molecular mechanisms underlying the intergenerational effects of prenatal sGC remain largely unknown. Here we show that prenatal dexamethasone (Dex) administration in late pregnancy induced depression-like behavior in first-generation (F1) offspring, which could be transmitted to second-generation (F2) offspring with maternal dependence...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Can Cihan, Abdullah Muti, Isinsu Baylam, Askin Kocabas, Umit Demirbas, Alphan Sennaroglu
We report, to the best of our knowledge, the shortest femtosecond pulses generated from a Kerr-lens mode-locked (KLM) Alexandrite laser operating near 750 nm. The Alexandrite gain medium was pumped with a continuous-wave (cw), 532 nm laser, and the performance of both the short and extended resonators was investigated. The use of an extended cavity eliminated the multi-wavelength spectral instabilities observed during the cw operation of the short cavity. Furthermore, since the repetition rate of the Alexandrite laser was reduced from 107 to 5...
March 15, 2018: Optics Letters
Franz Beier, Friedrich Möller, Bettina Sattler, Johannes Nold, Andreas Liem, Christian Hupel, Stefan Kuhn, Sigrun Hein, Nicoletta Haarlammert, Thomas Schreiber, Ramona Eberhardt, Andreas Tünnermann
In this contribution we investigate the transversal mode instability behavior of a ytterbium-doped commercial 20/400 fiber and obtain 2.9 kW of output power after optimizing the influencing parameters. In this context, we evaluate the influence of the bend diameter and the pump wavelength within the scope of the absorption length and the length of the fiber. Furthermore, with a newly developed fiber we report on 4.4 kW of single-mode output power at 40 cm bend diameter.
March 15, 2018: Optics Letters
Basmah Safdar, Gail D'Onofrio, James Dziura, Raymond R Russell, Caitlin Johnson, Albert J Sinusas
AIMS: Coronary microvascular dysfunction (CMD) is common in patients with non-obstructive coronary arteries but has not been described in low-risk symptomatic patients. We therefore assessed the prevalence and characteristics of CMD in low to moderate risk patients with chest pain in an emergency department. METHODS AND RESULTS: We used three-dimensional Rb82 cardiac positron emission tomography/computed tomography to diagnose coronary artery disease (known or new regional defect, any coronary calcification) and CMD (low coronary flow reserve without coronary artery disease) in chest pain patients after being ruled out for acute myocardial infarction...
March 1, 2018: European Heart Journal. Acute Cardiovascular Care
Nazim Boudjada, Gideon Wachtel, Arun Paramekanti
Recent experiments have explored two-dimensional electron gases (2DEGs) at oxide (111) surfaces and interfaces, finding evidence for hexagonal symmetry breaking in SrTiO_{3} at low temperature. We discuss many-body instabilities of such (111) 2DEGs, incorporating multiorbital interactions in the t_{2g} manifold which can induce diverse magnetic and orbital orders. Such broken symmetries may partly account for the observed nematicity, cooperating or competing with phonon mechanisms. We present an effective field theory for the interplay of magnetism and nematic charge order, and discuss implications of the nematicity for transport and superconductivity in (111) 2DEGs...
February 23, 2018: Physical Review Letters
Massimiliano Rossi, Nenad Kralj, Stefano Zippilli, Riccardo Natali, Antonio Borrielli, Gregory Pandraud, Enrico Serra, Giovanni Di Giuseppe, David Vitali
Normal-mode splitting is the most evident signature of strong coupling between two interacting subsystems. It occurs when two subsystems exchange energy between themselves faster than they dissipate it to the environment. Here we experimentally show that a weakly coupled optomechanical system at room temperature can manifest normal-mode splitting when the pump field fluctuations are antisquashed by a phase-sensitive feedback loop operating close to its instability threshold. Under these conditions the optical cavity exhibits an effectively reduced decay rate, so that the system is effectively promoted to the strong coupling regime...
February 16, 2018: Physical Review Letters
Aline Vochezer, Tobias Kampschulte, Klemens Hammerer, Philipp Treutlein
We observe effects of collective atomic motion in a one-dimensional optical lattice coupled to an optomechanical system. In this hybrid atom-optomechanical system, the lattice light generates a coupling between the lattice atoms as well as between atoms and a micromechanical membrane oscillator. For large atom numbers we observe an instability in the coupled system, resulting in large-amplitude atom-membrane oscillations. We show that this behavior can be explained by light-mediated collective atomic motion in the lattice, which arises for large atom numbers, small atom-light detunings, and asymmetric pumping of the lattice, in agreement with previous theoretical work...
February 16, 2018: Physical Review Letters
Z H Zhong, R X Tang, M Zhou, X H Deng, Y Pang, W R Paterson, B L Giles, J L Burch, R B Tobert, R E Ergun, Y V Khotyaintsev, P-A Lindquist
Secondary flux ropes are suggested to play important roles in energy dissipation and particle acceleration during magnetic reconnection. However, their generation mechanism is not fully understood. In this Letter, we present the first direct evidence that a secondary flux rope was generated due to the evolution of an electron vortex, which was driven by the electron Kelvin-Helmholtz instability in an ion diffusion region as observed by the Magnetospheric Multiscale mission. The subion scale (less than the ion inertial length) flux rope was embedded within the electron vortex, which contained a secondary electron diffusion region at the trailing edge of the flux rope...
February 16, 2018: Physical Review Letters
Dongshuai Hou, Tiejun Yang, Jinhui Tang, Shaochun Li
Graphene oxide (GO) reinforced cement nanocomposites open up a new path for sustainable concrete design. In this paper, reactive force-field molecular dynamics was utilized to investigate the structure, reactivity and interfacial bonding of calcium silicate hydrate (C-S-H)/GO nanocomposite functionalized by hydroxyl (C-OH), epoxy (C-O-C), carboxyl (COOH) and sulfonic (SO3 H) groups with a coverage of 10%. The silicate chains in the hydrophilic C-S-H substrate provided numerous non-bridging oxygen sites and counter ions (Ca ions) with high reactivity, which allowed interlayer water molecules to dissociate into Si-OH and Ca-OH...
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Liana J Petruzzi, Samuel J Pullen, Brittany C L Lange, Lindsey Parnarouskis, Silvia Dominguez, Benjamin Harris, Nicole Quiterio, Gondah Lekpeh, Burgess Manobah, David C Henderson, Christina P C Borba
Substance use is prevalent among youth in postconflict African countries and is associated with a number of public health problems such as poverty, child homelessness, and school truancy. This qualitative study explores the risk factors associated with substance use among Liberian youth from the perspective of public-school students. Nine focus groups were conducted with 72 Liberian public-school students (35 female, 37 male). Multiple risk factors for substance use among Liberian youth were identified through qualitative analysis, including emotional instability, gender, fear of academic failure, accessibility to substances within the school and community, poverty, and unintentional drug use...
March 1, 2018: Qualitative Health Research
Benjamin L Solomon, Ignacio Garrido-Laguna
The advent of immune checkpoint inhibitors (PD-1, PD-L1 and CTLA-4) has resulted in unprecedented long-term remissions of unresectable cancers. The efficacy of checkpoint inhibitors was recently demonstrated in gastrointestinal malignancies with mismatch repair deficiencies (dMMR). Pembrolizumab became the first tissue-agnostic US FDA-approved drug based on the presence of the predictive biomarker dMMR. In addition, the FDA in 2017 approved pembrolizumab for PD-L1-positive advanced gastric cancer in third-line and second-line hepatocellular therapy...
March 15, 2018: Future Oncology
L G J Leijssen, A M Dinaux, H Kunitake, L G Bordeianou, D L Berger
PURPOSE: Proximal and distal colon cancers differ in terms of epidemiology, clinical presentation, and pathologic features. The aim of our study was to evaluate the impact of right-sided (RC), transverse (TC), and left-sided (LC) colon cancer on morbidity rates and oncological outcomes. METHODS: A retrospective analysis of patients with resected colon cancer between 2004 and 2014 was conducted. Cox proportional hazard models were used to assess predictors of overall (OS), and disease-specific survival (DSS), as well as disease-free survival (DFS)...
March 14, 2018: International Journal of Colorectal Disease
Iain Rankin, Haroon Rehman, Mark Frame
Background: Traditional ACL reconstruction with non-anatomic techniques can demonstrate unsatisfactory long-term outcomes with regards instability and the degenerative knee changes observed with these results. Anatomic ACL reconstruction attempts to closely reproduce the patient's individual anatomic characteristics with the aim of restoring knee kinematics, in order to improve patient short and long-term outcomes. We designed an arthroscopic, patient-specific, ACL femoral tunnel guide to aid anatomical placement of the ACL graft within the femoral tunnel...
2018: Open Orthopaedics Journal
Bo Li, Yanan Zhang, Lin Fu, Tong Yu, Shujie Zhou, Luyuan Zhang, Longwei Yin
Owing to inevitable thermal/moisture instability for organic-inorganic hybrid perovskites, pure inorganic perovskite cesium lead halides with both inherent stability and prominent photovoltaic performance have become research hotspots as a promising candidate for commercial perovskite solar cells. However, it is still a serious challenge to synthesize desired cubic cesium lead iodides (CsPbI3 ) with superior photovoltaic performance for its thermodynamically metastable characteristics. Herein, polymer poly-vinylpyrrolidone (PVP)-induced surface passivation engineering is reported to synthesize extra-long-term stable cubic CsPbI3 ...
March 14, 2018: Nature Communications
Yoshihiko Satake, Yuji Tomori, Takuya Sawaizumi, Mitsuhiko Nanno, Norie Kodera, Shinro Takai
Medial epicondyle fractures of the humerus account for 11%-20% of all elbow injuries in children. Although intra-articular incarceration of the medial epicondyle occurs in 5%-18% of medial epicondyle fractures associated with an elbow dislocation, the mechanism of intrusion of the fracture fragment is unknown. We report a case of an irreducible elbow fracture and dislocation due to incarceration of the medial epicondyle fragment of the humerus, classified as a Watson-Jones type 3 fracture of the medial epicondyle, and present the mechanism of the intra-articular incarceration of the medial epicondyle fragment...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
JongEun Yim, Jerrold Petrofsky, Haneul Lee
Ankle and foot injuries are common among athletes and physically active individuals. The most common residual disability, ankle sprain, is characterized by instability along with postural sway. If the supporting structures around a joint become lax, posture stability and balance are also affected. Previous studies have examined muscle stiffness and elasticity and postural sway separately; however, the relationship between these factors is yet unknown. It is well known that the levels of sex hormones, especially estrogen, change in women over the phase of the menstrual cycle...
2018: Tohoku Journal of Experimental Medicine
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