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https://www.readbyqxmd.com/read/28090595/a-case-of-coats-disease-and-concurrent-anisometropic-amblyopia
#1
Nathan G Lambert, Robert O Hoffman, M Elizabeth Hartnett
PURPOSE: The aim of this report was to demonstrate a case of Coats disease in a patient with concurrent anisometropic amblyopia. OBSERVATIONS: A 10-year-old boy was diagnosed with Coats disease during routine ophthalmic examination. Visual acuity was 20/20 OD and 20/50 OS with cycloplegic refraction of +1.25 (OD) and +3.25 (OS). Examination under anesthesia showed macular exudates in the left eye that encroached near the fovea superotemporally. Despite the poor visual acuity and macular exudates, the foveal architecture of both eyes appeared normal on spectral domain optical coherence tomography...
December 2016: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/28089909/immunosuppression-via-loss-of-il2r%C3%AE-enhances-long-term-functional-integration-of-hesc-derived-photoreceptors-in-the-mouse-retina
#2
Jie Zhu, Helen Cifuentes, Joseph Reynolds, Deepak A Lamba
Loss of photoreceptors is a common endpoint in degenerative retinal diseases. Human pluripotent stem cells provide a potential source for photoreceptor replacement, but, even in mouse models, the efficiency and efficacy of transplantation-based repair remains poor. In this study, we examined the degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor γ (IL2rγ)-null mouse model. Our results show that prevention of cell rejection in the normal and degenerating retinal environment significantly improves long-term survival and integration of hESC-derived donor retinal cells...
December 29, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/28089775/degenerative-effects-of-cobalt-chloride-treatment-on-neurons-and-microglia-in-a-porcine-retina-organ-culture-model
#3
S Kuehn, J Hurst, F Rensinghoff, T Tsai, S Grauthoff, Y Satgunarajah, H B Dick, S Schnichels, S C Joachim
In order to understand the pathological processes of retinal diseases, experimental models are necessary. Cobalt, as part of the vitamin B12 complex, is important for neuronal integrity. However, it is known that high quantities of cobalt induce cytotoxic mechanisms via hypoxia mimicry. Therefore, we tested the degenerative effect of cobalt chloride (CoCl2) on neurons and microglia in a porcine retina organ culture model. Organotypic cultures of porcine retinas were cultured and treated with different concentrations of CoCl2 (0, 100, 300 and 500 μM) for 48 h...
January 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28089680/peripheral-retinal-changes-associated-with%C3%A2-age-related-macular-degeneration-in%C3%A2-the-age-related-eye-disease-study-2-age-related-eye-disease-study-2-report-number-12-by-the%C3%A2-age-related-eye-disease-study-2-optos-peripheral-retina-opera-study-research-group
#4
Amitha Domalpally, Traci E Clemons, Ronald P Danis, SriniVas R Sadda, Catherine A Cukras, Cynthia A Toth, Thomas R Friberg, Emily Y Chew
PURPOSE: To compare rates of peripheral retinal changes in Age-Related Eye Disease Study 2 (AREDS2) participants with at least intermediate age-related macular degeneration (AMD) with control subjects without intermediate age-related changes (large drusen). DESIGN: Cross-sectional evaluation of clinic-based patients enrolled in AREDS2 and a prospective study. PARTICIPANTS: Participants from prospective studies. METHODS: The 200° pseudocolor and fundus autofluorescence (FAF) images were captured on the Optos 200 Tx Ultrawide-field device (Optos, Dunfermline, Scotland) by centering on the fovea and then steering superiorly and inferiorly...
January 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28088912/melatonin-as-a-therapeutic-resource-for-inflammatory-visual-diseases
#5
Marcos L Aranda, María Florencia González Fleitas, Hernán Dieguez, Agustina Iaquinandi, Pablo H Sande, Damián Dorfman, Ruth E Rosenstein
BACKGROUND: Uveitis and optic neuritis are prevalent ocular inflammatory diseases, and highly damaging ocular conditions. Both diseases are currently treated with corticosteroids, but they do not have adequate efficacy and are often associated with severe side effects. Thus, uveitis and optic neuritis remain a challenging field to ophthalmologists and a significant public health concern. OBJECTIVE: This review summarizes findings showing the benefits of a treatment with melatonin in experimental models of these inflammatory ocular diseases...
January 13, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28080153/long-term-change-of-subfoveal-choroidal-thickness-in-beh%C3%A3-et-s-disease-patients-with-posterior-uveitis
#6
UnChul Park, In Hwan Cho, Sang Woong Moon, Hyeong Gon Yu
PURPOSE: To evaluate long-term changes of subfoveal choroidal thickness (SCT) in Behçet's disease (BD) patients with posterior uveitis. METHODS: Changes in SCT measured with enhanced depth imaging optical coherence tomography during quiescent phase were assessed during >24 months in 63 BD patients and control group. RESULTS: Baseline characteristics showed no difference, but the BD group showed poorer visual acuity (p = 0.013) and smaller SCT (p = 0...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28078992/smoking-and-eye-pathologies-a-systemic-review-part-ii-retina-diseases-uveitis-optic-neuropathies-thyroid-associated-orbitopathy
#7
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health. AIM: The analysis of influence of tobacco smoking on retina diseases, uveitis, optic neuropathies, and thyroid-associated orbitopathy in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, covering the years 2000-2016. RESULTS: In adults, tobacco smoking is a strong risk factor for age-related macular degeneration, polypoidal choroidal vasculopathy, uveitis and inflamed cystoid macular edema as well as Grave`s ophthalmopathy...
January 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28077493/disease-modifying-therapies-modulate-retinal-atrophy-in-multiple-sclerosis-a-retrospective-study
#8
Julia Button, Omar Al-Louzi, Andrew Lang, Pavan Bhargava, Scott D Newsome, Teresa Frohman, Laura J Balcer, Elliot M Frohman, Jerry Prince, Peter A Calabresi, Shiv Saidha
OBJECTIVE: To retrospectively investigate whether disease-modifying therapies (DMTs) exert differential effects on rates of retinal atrophy in relapsing-remitting multiple sclerosis (RRMS), as assessed using optical coherence tomography (OCT). METHODS: A total of 402 patients with RRMS followed at the Johns Hopkins MS Center who underwent Cirrus-HD OCT were assessed for eligibility. Inclusion criteria included at least 1 year of OCT follow-up and adherence to a single DMT during the period of follow-up...
January 11, 2017: Neurology
https://www.readbyqxmd.com/read/28075618/rodent-models-of-glaucoma-and-their-applicability-for-drug-discovery
#9
Renu Agarwal, Puneet Agarwal
Rodents have widely been used to represent glaucomatous changes both in the presence and absence of elevated intraocular pressure (IOP) as they offer clear advantages over other animal species. IOP elevation is commonly achieved by creating an obstruction in the aqueous outflow pathways, consequently leading to retinal ganglion cell (RGCs) and optic nerve (ON) damage, the hallmark of glaucoma. These changes may also be achieved in the absence of elevated IOP by directly inflicting injury to retina or ON. Areas covered: This paper presents a summary of currently used rodent models of glaucoma...
January 11, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28070965/the-consequences-of-avian-ocular-trauma-histopathological-evidence-and-implications-of-acute-and-chronic-disease
#10
Bret A Moore, Leandro B C Teixeira, William E Sponsel, Richard R Dubielzig
OBJECTIVE: To present a description and categorization of the histopathological lesions in avian ocular trauma. ANIMAL STUDIED: Seventy-five birds diagnosed with ocular trauma at to the Comparative Ocular Pathology Laboratory of Wisconsin. PROCEDURES: Histological slides were reviewed, and the type of trauma was classified by cause into either (i) blunt trauma or (ii) penetrating trauma and by duration into (i) acute or (ii) chronic. RESULTS: Blunt trauma was the most common source of trauma, and the most frequent lesions were observed in the retina (91%), with 71% of retinas having a tear or detachment and 46% of retinas showing chronic degenerative changes...
January 10, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28062197/assessment-of-patient-reported-outcomes-in-retinal-diseases-a-systematic-review
#11
Mallika Prem Senthil, Jyoti Khadka, Konrad Pesudovs
Advances in the understanding of the genetic, molecular and cellular biology of retinal diseases have led to the development of new treatments. These expanding treatment options demand appropriate outcome measures for studies of treatment benefit including patient-reported outcomes (PRO). A plethora of PRO instruments assess impacts of retinal diseases from the patients' perspectives. We review all of the studies that implemented PRO assessment in retinal diseases and also discuss quality assessment of the PRO instruments...
January 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28061512/assessment-of-rod-cone-and-intrinsically-photosensitive-retinal-ganglion-cell-contributions-to-the-canine-chromatic-pupillary-response
#12
Connie Y Yeh, Kristin L Koehl, Christine D Harman, Simone Iwabe, José M Guzman, Simon M Petersen-Jones, Randy H Kardon, András M Komáromy
Purpose: The purpose of this study was to evaluate a chromatic pupillometry protocol for specific functional assessment of rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) in dogs. Methods: Chromatic pupillometry was tested and compared in 37 dogs in different stages of primary loss of rod, cone, and combined rod/cone and optic nerve function, and in 5 wild-type (WT) dogs. Eyes were stimulated with 1-s flashes of dim (1 cd/m2) and bright (400 cd/m2) blue light (for scotopic conditions) or bright red (400 cd/m2) light with 25-cd/m2 blue background (for photopic conditions)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28060396/vascular-features-of-full-thickness-macular-hole-by-oct-angiography
#13
Stanislao Rizzo, Alfonso Savastano, Daniela Bacherini, Maria Cristina Savastano
BACKGROUND AND OBJECTIVE: To compare the features of cystoid cavities associated with full-thickness macular hole (FTMH) imaged with optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Prospective, observational, cross-sectional study. Clinical practice and observation. Thirteen patients (13 eyes) with FTMH were evaluated before vitrectomy. All eyes underwent OCTA or en face OCT imaging. RESULTS: There was a statistically significant positive correlation between groups for the total cavity area in both inner nuclear layer (P < ...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060390/asymptomatic-progression-of-ocular-beh%C3%A3-et-s-disease
#14
Marina Roizenblatt, Nikoly Fares, Heloisa Nascimento, Eduardo A Novais, Cristina Muccioli, Rubens Belfort
BACKGROUND AND OBJECTIVE: To emphasize the importance of auxiliary exams to detect progression of ocular Behçet's disease (BD) in asymptomatic patients. PATIENTS AND METHODS: This was a retrospective review of the clinical records of a consecutive series of patients with BD and asymptomatic visual deterioration, imaged on fundus photograph (FP), visual field (VF), fluorescein angiography (FA), and optical coherence tomography (OCT). RESULTS: Patients presented with no clinical findings or with mild inflammation on ophthalmic examination...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28060358/electronic-retinal-implant-surgery
#15
R E MacLaren
Blindness due to outer retinal degeneration still remains largely untreatable. Photoreceptor loss removes light sensitivity, but the remaining inner retinal layers, the optic nerve, and indeed the physical structure of the eye itself may be unaffected by the degenerative processes. This provides the opportunity to restore some degree of vision with an electronic device in the subretinal space. In this lecture I will provide an overview of our experiences with the first-generation retinal implant Alpha IMS, developed by Retina Implant AG and based on the technology developed by Eberhart Zrenner as part of a multicentre clinical trial (NCT01024803)...
January 6, 2017: Eye
https://www.readbyqxmd.com/read/28060316/an-alternative-and-validated-injection-method-for-accessing-the-subretinal-space-via-a-transcleral-posterior-approach
#16
Sachin Parikh, Andrew Le, Julian Davenport, Michael B Gorin, Steven Nusinowitz, Anna Matynia
Subretinal injections have been successfully used in both humans and rodents to deliver therapeutic interventions of proteins, viral agents, and cells to the interphotoreceptor/subretinal compartment that has direct exposure to photoreceptors and the retinal pigment epithelium (RPE). Subretinal injections of plasminogen as well as recent preclinical and clinical trials have demonstrated safety and/or efficacy of delivering viral vectors and stem cells to individuals with advanced retinal disease. Mouse models of retinal disease, particularly hereditary retinal dystrophies, are essential for testing these therapies...
December 7, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28060137/infants-with-congenital-zika-syndrome-and-ocular-findings-from-s%C3%A3-o-paulo-brazil-spread-of-infection
#17
João Rafael de Oliveira Dias, Camila V Ventura, Paula Delegrego Borba, Bruno de Paula Freitas, Ligia Camera Pierroti, Ana Patricia do Nascimento, Nilva Simeren Bueno de Moraes, Maurício Maia, Rubens Belfort
BACKGROUND/PURPOSE: To describe the ocular findings of two infants with congenital Zika syndrome born in São Paulo state, Brazil, outside the primary outbreak region. METHODS: Two female infants with congenital Zika syndrome were submitted to a complete screening for infectious diseases, as well as ocular examination, fundus photography, and optical coherence tomography of the retina. One of the infants was submitted to ocular ultrasound. RESULTS: Both children showed positive serology for Zika virus, and other infectious diseases were ruled out...
January 2, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28058163/clinical-features-and-course-of-patients-with-peripheral-exudative-hemorrhagic-chorioretinopathy
#18
Zafer Cebeci, Yasemin Dere, Şerife Bayraktar, Samuray Tuncer, Nur Kır
OBJECTIVES: To evaluate the clinical characteristics of patients who were followed in our clinic with the diagnosis of peripheral exudative hemorrhagic chorioretinopathy (PEHC). MATERIALS AND METHODS: Medical records of 12 patients who were diagnosed with PEHC in İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology between July 2006 and June 2014 were reviewed retrospectively. RESULTS: This study included 21 eyes of 12 patients...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057649/choroid-morphometric-analysis-in-non-neovascular-age-related-macular-degeneration-by-means-of-optical-coherence-tomography-angiography
#19
Maria Vittoria Cicinelli, Alessandro Rabiolo, Alessandro Marchese, Luigi de Vitis, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
AIMS: To describe the vascular changes in patients affected by non-neovascular age-related macular degeneration (AMD), featuring reticular pseudodrusen (RPD), drusen, or both RPD and drusen by means of optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional observational case series. Patients with non-neovascular AMD presenting at the Medical Retina Service of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057562/imaging-retina-to-study-dementia-and-stroke
#20
REVIEW
Carol Yim-Lui Cheung, M Kamran Ikram, Christopher Chen, Tien Yin Wong
With increase in life expectancy, the number of persons suffering from common age-related brain diseases, including neurodegenerative (e.g., dementia) and cerebrovascular (e.g., stroke) disease is expected to rise substantially. As current neuro-imaging modalities such as magnetic resonance imaging may not be able to detect subtle subclinical changes (resolution <100-500 μm) in dementia and stroke, there is an urgent need for other complementary techniques to probe the pathophysiology of these diseases...
January 2, 2017: Progress in Retinal and Eye Research
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