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https://www.readbyqxmd.com/read/29154822/mef2-and-the-skeletal-muscle-differentiation-program
#1
REVIEW
Michael V Taylor, Simon M Hughes
Mef2 is a conserved and significant transcription factor in the control of muscle gene expression. In cell culture Mef2 synergises with MyoD-family members in the activation of gene expression and in the conversion of fibroblasts into myoblasts. Amongst its in vivo roles, Mef2 is required for both Drosophila muscle development and mammalian muscle regeneration. Mef2 has functions in other cell-types too, but this review focuses on skeletal muscle and surveys key findings on Mef2 from its discovery, shortly after that of MyoD, up to the present day...
November 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29154020/skeletal-surveys-in-young-injured-children-a-systematic-review
#2
REVIEW
Christine W Paine, Joanne N Wood
Skeletal surveys (SSs) have been identified as a key component of the evaluation for suspected abuse in young children, but variability in SS utilization has been reported. Thus, we aimed to describe the utilization patterns, yield, and risks of obtaining SS in young children through a systematic literature review. We searched PubMed/MEDLINE and CINAHL databases for articles published between 1990 and 2016 on SS. We calculated study-specific percentages of SS utilization and detection of occult fractures and examined the likelihoods that patient characteristics predict SS utilization and detection of occult fractures...
November 15, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29144443/a-genomic-survey-of-scpp-family-genes-in-fishes-provides-novel-insights-into-the-evolution-of-fish-scales
#3
Yunyun Lv, Kazuhiko Kawasaki, Jia Li, Yanping Li, Chao Bian, Yu Huang, Xinxin You, Qiong Shi
The family of secretory calcium-binding phosphoproteins (SCPPs) have been considered vital to skeletal tissue mineralization. However, most previous SCPP studies focused on phylogenetically distant animals but not on those closely related species. Here we provide novel insights into the coevolution of SCPP genes and fish scales in 10 species from Otophysi. According to their scale phenotypes, these fishes can be divided into three groups, i.e., scaled, sparsely scaled, and scaleless. We identified homologous SCPP genes in the genomes of these species and revealed an absence of some SCPP members in some genomes, suggesting an uneven evolutionary history of SCPP genes in fishes...
November 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29137472/changes-in-transcription-pattern-lead-to-a-marked-decrease-in-cox-cs-and-sqr-activity-after-the-developmental-point-of-the-22-nd-gestational-week
#4
H Kolarova, J Krizova, M Hulkova, H Hansikova, H Hulkova, V Smid, J Zeman, T Honzik, M Tesarova
Tissue differentiation and proliferation throughout fetal development interconnect with changes in the Oxidative Phosphorylation System (OXPHOS) on the cellular level. Reevaluation of the expression data revealed a significant increase in COX4 and MTATP6 liver transcription levels after the 22(nd) gestational week (GW) which inspired us to characterize its functional impact. Specific activities of cytochrome c oxidase (COX), citrate synthase (CS), succinate-coenzyme Q reductase (SQR) and mtDNA determined by spectrophotometry and RT-PCR were studied in a set of 25 liver and 18 skeletal muscle samples at 13(th) to 29(th) GW...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29134173/associations-of-lifetime-walking-and-weight-bearing-exercise-with-accelerometer-measured-high-impact-physical-activity-in-later-life
#5
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark, Charlotte Moss, Mark H Edwards, Elaine Dennison, Tim Gaysin, Diana Kuh, Andrew Wong, Kenneth R Fox, Cyrus Cooper, Rachel Cooper, Jon H Tobias
High impact physical activity (PA) is thought to benefit bone. We examined associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact and overall PA in later life. Data were from 848 participants (66.2% female, mean age = 72.4 years) from the Cohort for Skeletal Health in Bristol and Avon, Hertfordshire Cohort Study and MRC National Survey of Health and Development. Acceleration peaks from seven-day hip-worn accelerometer recordings were used to derive counts of high impact and overall PA...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29129347/international-society-for-the-study-of-vascular-anomalies-classification-of-soft-tissue-vascular-anomalies-survey-based-assessment-of-musculoskeletal-radiologists-use-in-clinical-practice
#6
Shivani Ahlawat, Laura M Fayad, Daniel J Durand, Kate Puttgen, Aylin Tekes
AIM: There is controversy regarding the diagnosis and classification of vascular anomalies (VA). As torso and extremities are the second most common body part for presentation of VAs, musculoskeletal (MSK) radiologists play a central role in VA classification. The purpose of this study was to evaluate the awareness and clinical use of the International Society for the Study of Vascular Anomalies (ISSVA) classification by MSK radiologists. MATERIALS AND METHODS: A Web-based survey was designed and electronically sent to Society of Skeletal Radiology (SSR) members, with 3 questions on demographics and 7 questions on ISSVA classification use and knowledge...
October 16, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29123920/a-prospective-study-comparing-whole-body-skeletal-x-ray-survey-with-18f-fdg-pet-ct-18f-naf-pet-ct-and-whole-body-mri-in-the-detection-of-bone-lesions-in-multiple-myeloma-patients
#7
Eva Dyrberg, Helle W Hendel, Gina Al-Farra, Lone Balding, Vibeke B Løgager, Claus Madsen, Henrik S Thomsen
Background: For decades, the most widely used imaging technique for myeloma bone lesions has been a whole-body skeletal X-ray survey (WBXR), but newer promising imaging techniques are evolving. Purpose: To compare WBXR with the advanced imaging techniques 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT), 18F-sodium fluoride (NaF) PET/CT and whole-body magnetic resonance imaging (WB-MRI) in the detection of myeloma bone lesions...
October 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/29120677/relationships-between-25-oh-d-concentration-sarcopenia-and-homa-ir-in-postmenopausal-korean-women
#8
J H Lee, S Kim, M K Kim, B H Yun, S Cho, Y S Choi, B S Lee, S K Seo
OBJECTIVE: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. METHODS: This study used data from the Korea National Health and Nutrition Examination Survey 2008-2011...
November 9, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29118315/balancing-medical-and-non-accidental-causes-of-multiple-fractures-in-a-child-with-progressive-familial-intrahepatic-cholestasis
#9
Hisham Abdelrhim, Sami Khan, Paul Heaton, Rajeev Peeka
BACKGROUND All medical practitioners must be vigilant for child abuse and neglect (CAN) so that opportunities to intervene, prevent, and improve outcomes are not missed. However, child abuse is often overlooked in practice, and no sign or pattern of presentation of fractures is absolutely specific for child abuse. CASE REPORT Here, we present the case of a 22-month-old girl with progressive familial intrahepatic cholestasis (PFIC) type 2 who presented with "red flag" fractures indicative of child abuse. Biochemistry showed vitamin D deficiency and a skeletal survey revealed rickets and multiple pathological fractures...
November 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29104842/concurrent-multiple-myeloma-and-metastatic-osteosarcoma-a-case-report-and-literature-review
#10
Ashley Ramirez, Vincent Grekoski, Michael Valente, Fiona Tissavirasingham, Alessandra Fahey, Nicole Guevara, John W Stelzer, M Joe Ma, Jeremy Burt
Multiple myeloma (MM) and osteosarcoma (OS) are two common bone malignancies, however, the simultaneous occurrence of both primary bone tumors in the same patient has not been reported in the United States to date. We present a unique case in which both malignancies present concurrently in a 72-year-old man. Results of spinal magnetic resonance imaging (MRI), radiographic skeletal survey, and hematological workup established the initial diagnosis of MM. Approximately three months later, the patient was admitted with severe right hip pain and shortness of breath and was evaluated with computed tomography (CT) of the right hip, abdomen, pelvis, and chest, revealing an osseous mass with a "sunburst" pattern in the right hip, and several calcified nodules in the lungs...
August 31, 2017: Curēus
https://www.readbyqxmd.com/read/29104458/gender-specific-associations-between-low-skeletal-muscle-mass-and-albuminuria-in-the-middle-aged-and-elderly-population
#11
Hye Eun Yoon, Yunju Nam, Eunjin Kang, Hyeon Seok Hwang, Seok Joon Shin, Yeon Sik Hong, Kwi Young Kang
Objective This study assessed gender-specific associations between low muscle mass (LMM) and albuminuria. Methods Data from the Korea National Health and Nutrition Examination Survey 2011 were employed. The study consisted of 1,087 subjects (≥50 years old). Skeletal muscle index (SMI) was defined as the weight-adjusted appendicular skeletal muscle mass. Mild LMM and severe LMM were defined as SMI that were 1-2 and >2 standard deviations below the sex-specific mean appendicular skeletal muscle mass of young adults, respectively...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29102964/oral-injuries-and-occult-harm-in-children-evaluated-for-abuse
#12
Molly V Dorfman, James B Metz, Kenneth W Feldman, Reid Farris, Daniel M Lindberg
OBJECTIVE: To determine the frequency of occult trauma in children with oral injury evaluated for physical abuse. DESIGN: This was a retrospectively planned secondary analysis of a prospective, observational study. SETTING: Emergency departments supported by 20 US child abuse teams in the Examining Siblings to Recognize Abuse (ExSTRA) network. PATIENTS: Children <120 months old evaluated for physical abuse. INTERVENTIONS: Analysis of index children with oral injury on initial examination...
November 4, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29101908/using-drone-mounted-cameras-for-on-site-body-documentation-3d-mapping-and-active-survey
#13
Petra Urbanová, Mikoláš Jurda, Tomáš Vojtíšek, Jan Krajsa
Recent advances in unmanned aerial technology have substantially lowered the cost associated with aerial imagery. As a result, forensic practitioners are today presented with easy low-cost access to aerial photographs at remote locations. The present paper aims to explore boundaries in which the low-end drone technology can operate as professional crime scene equipment, and to test the prospects of aerial 3D modeling in the forensic context. The study was based on recent forensic cases of falls from height admitted for postmortem examinations...
October 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29090589/hand-grip-strength-and-peak-expiratory-flow-among-individuals-with-diabetes-findings-from-the-china-health-and-retirement-longitudinal-study-baseline-survey
#14
Tianrong Ma, Tingting Liu, Dongmei Wu, Changwei Li
The manifestation of muscle dysfunction associated with diabetes is commonly observed in skeletal muscles. The negative effect of hyperglycemia on muscle function is systemic and it may extend to abdominal muscles. Hence, the purpose of this study was to determine whether hand grip strength (HGS), an indicator of peripheral muscle strength, correlates with peak expiratory flow (PEF), which reflects the strength of abdominal muscles, among middle-aged and older Chinese individuals with diabetes. After controlling for all variables except for physical activity, 10 L/min increase in PEF was associated with 0...
October 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/29083447/animal-derived-protein-consumption-is-associated-with-muscle-mass-and-strength-in-community-dwellers-results-from-the-milan-expo-survey
#15
F Landi, R Calvani, M Tosato, A M Martone, A Picca, E Ortolani, G Savera, S Salini, M Ramaschi, R Bernabei, E Marzetti
OBJECTIVES: Behavioral factors, including protein intake, influence the quantity and quality of skeletal muscle. The aim of this study was to explore the relationship between animal-derived protein intake and muscle mass and function in a large sample of unselected community-dwellers. MATERIAL AND METHODS: The VIP (Very Important Protein) study, conducted during Expo 2015 in Milan, was a population survey aimed at assessing major health metrics in a population outside of the research setting, with a special focus on the relation between animal-derived protein intake and muscle mass and function...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29075109/echo-intensity-of-the-rectus-femoris-in-stable-copd-patients
#16
Xiong Ye, Mingjie Wang, Hui Xiao
OBJECTIVE: The aim of this study was to investigate whether echo intensity of the rectus femoris when measured using ultrasound can distinguish muscles affected by COPD compared with healthy non-COPD affected muscles and whether the severity of ultrasonic abnormalities was associated with health-related quality of life (HRQoL). METHODS: Echo intensity, areas of the rectus femoris, and the thickness of quadriceps muscles were measured using ultrasound in 50 COPD outpatients and 21 age-matched non-COPD controls...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29066504/patient-quality-of-life-and-prognosis-in-men2
#17
Joanna Grey, Kym Winter
Multiple endocrine neoplasia type 2 (MEN2) refers to the autosomal dominant neuroendocrine tumour syndromes, MEN type 2A (MEN2A) and MEN type 2B (MEN2B). They are typified by the development of medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid hyperplasia in MEN2A, and MTC, phaeochromocytomas, ganglioneuromatosis and skeletal abnormalities in MEN2B. The aggressiveness of MTC is variable according to genotype, and although it is still the major cause of mortality in both conditions, prognosis has improved dramatically in those diagnosed and treated at a young age thanks to predictive genetic testing...
October 24, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29057130/cutaneous-vasculitis-an-unusual-presentation-of-a-biclonal-nodal-plasma-cell-dyscrasia
#18
D Swan, M Murphy, E Elhassadi
We describe an unusual case of a biclonal nodal plasma cell dyscrasia, presenting with a vasculitic rash, end-organ damage, and cytopenias. Serum protein electrophoresis demonstrated a biclonal kappa-restricted paraprotein, with a negative skeletal survey and no bone marrow disease. Fluorodeoxyglucose-PET-CT (FDG-PET-CT) revealed nodal involvement, which was not appreciable clinically, and facilitated biopsy, confirming the diagnosis of a nodal plasmacytoma. Complete biochemical response and resolution of the vasculitic rash were achieved with bortezomib-based therapy...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29038396/multiple-myeloma-in-a-patient-with-familial-mediterranean-fever
#19
Bahman Bashardoust, Nasrollah Maleki
Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. The coexistence of multiple myeloma (MM) and FMF is an extremely rare event. Here, we report a case of FMF with concurrent MM. A 63-year-old woman was diagnosed with FMF since 15 years earlier. She was admitted with a complaint of low back pain. Regarding the presence of back pain, anemia, hypercalcemia, and kidney failure, a diagnosis of MM was suspected...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29028919/physical-activity-producing-low-but-not-medium-or-higher-vertical-impacts-is-inversely-related-to-bmi-in-older-adults-findings-from-a-multi-cohort-study
#20
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark, Charlotte Moss, Mark H Edwards, Elaine Dennison, Tim Gaysin, Diana Kuh, Andrew Wong, Cyrus Cooper, Rachel Cooper, Jon H Tobias
Background: High impact physical activity (PA) is thought to improve skeletal health but its relation to other health outcomes are unclear. We investigated associations between PA impact magnitude and body mass index (BMI) in older adults. Methods: Data were from the Cohort for Skeletal Health in Bristol and Avon (COSHIBA), Hertfordshire Cohort Study and MRC National Survey of Health and Development. Vertical accelerations peaks from seven-day hip-worn accelerometer recordings were used to classify PA as low (0...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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