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https://www.readbyqxmd.com/read/27909972/can-we-estimate-short-and-intermediate-term-survival-in-patients-undergoing-surgery-for-metastatic-bone-disease
#1
Jonathan A Forsberg, Rikard Wedin, Patrick J Boland, John H Healey
BACKGROUND: Objective means of estimating survival can be used to guide surgical decision-making and to risk-stratify patients for clinical trials. Although a free, online tool ( www.pathfx.org ) can estimate 3- and 12-month survival, recent work, including a survey of the Musculoskeletal Tumor Society, indicated that estimates at 1 and 6 months after surgery also would be helpful. Longer estimates help justify the need for more durable and expensive reconstructive options, and very short estimates could help identify those who will not survive 1 month and should not undergo surgery...
December 1, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27902701/heads-shoulders-elbows-knees-and-toes-modular-gdf5-enhancers-control-different-joints-in-the-vertebrate-skeleton
#2
Hao Chen, Terence D Capellini, Michael Schoor, Doug P Mortlock, A Hari Reddi, David M Kingsley
Synovial joints are crucial for support and locomotion in vertebrates, and are the frequent site of serious skeletal defects and degenerative diseases in humans. Growth and differentiation factor 5 (Gdf5) is one of the earliest markers of joint formation, is required for normal joint development in both mice and humans, and has been genetically linked to risk of common osteoarthritis in Eurasian populations. Here, we systematically survey the mouse Gdf5 gene for regulatory elements controlling expression in synovial joints...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27897415/sarcopenia-among-patients-receiving-hemodialysis-weighing-the-evidence
#3
Piyawan Kittiskulnam, Juan J Carrero, Glenn M Chertow, George A Kaysen, Cynthia Delgado, Kirsten L Johansen
BACKGROUND: There is no consensus on how best to define low muscle mass in patients with end-stage renal disease. Use of muscle mass normalized to height-squared has been suggested by geriatric societies but may underestimate sarcopenia, particularly in the setting of excess adiposity. We compared four definitions of low muscle mass in a prevalent hemodialysis cohort. METHODS: ACTIVE/ADIPOSE enrolled prevalent patients receiving hemodialysis from the San Francisco and Atlanta areas from June 2009 to August 2011...
August 11, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27891032/clinical-anatomy-and-significance-of-the-thoracic-intervertebral-foramen-a-cadaveric-study-and-review-of-the-literature
#4
Grigorios Gkasdaris, Grigorios Tripsianis, Konstantinos Kotopoulos, Stylianos Kapetanakis
INTRODUCTION: The literature is lacking information on the anatomy and the osseous dimensions of the thoracic intervertebral foramen (IVF). We describe the anatomy of the broader area, and we proceed with morphometric data of the vertebrae and the foramina. Depiction of these features is provided with imaging and illustrations. The purpose of this paper is to survey and present the anatomy of the foramen as a whole and provide baseline statistical data. MATERIALS AND METHODS: We review relevant literature, and we present data obtained from skeletal samples of known population and sex...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27890699/ayurvedic-management-of-spondyloepiphyseal-dysplasia-tarda-a-rare-hereditary-disorder
#5
Sarvesh Kumar Singh, Kshipra Rajoria
Spondyloepiphyseal dysplasia tarda (SEDT) is a rare genetic disease in which patient suffers from short stature, short trunk and neck with disproportionately long arms, coxa vara, skeletal features such as barrel shaped chest, kyphosis, scoliosis and early arthropathy. Only limited medical and surgical management is available in modern medicine. A 15 years old male suffering from SEDT and diagnosed as Vata vyadhi was treated with Panchakarma therapy and selected Ayurvedic oral medicines. Ayurvedic treatment was directed to ameliorate the orthopaedic clinical conditions in this case...
November 25, 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27885410/is-osteoporosis-a-predictor-for-future-sarcopenia-or-vice-versa-four-year-observations-between-the-second-and-third-road-study-surveys
#6
N Yoshimura, S Muraki, H Oka, T Iidaka, R Kodama, H Kawaguchi, K Nakamura, S Tanaka, T Akune
: In a 4-year follow-up study that enrolled 1099 subjects aged ≥60 years, sarcopenia prevalence was estimated at 8.2%. Moreover, the presence of osteoporosis was significantly associated with short-term sarcopenia occurrence, but the reciprocal relationship was not observed, suggesting that osteoporosis would increase the risk of osteoporotic fracture and sarcopenia occurrence. INTRODUCTION: The present 4-year follow-up study was performed to clarify the prevalence, incidence, and relationships between sarcopenia (SP) and osteoporosis (OP) in older Japanese men and women...
November 24, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27884657/the-origin-and-diversification-of-the-developmental-mechanisms-that-pattern-the-vertebrate-head-skeleton
#7
REVIEW
Tyler Square, David Jandzik, Marek Romášek, Robert Cerny, Daniel Medeiros
The apparent evolvability of the vertebrate head skeleton has allowed a diverse array of shapes, sizes, and compositions of the head in order to better adapt species to their environments. This encompasses feeding, breathing, sensing, and communicating: the head skeleton somehow participated in the evolution of all these critical processes for the last 500 million years. Through evolution, present head diversity was made possible via developmental modifications to the first head skeletal genetic program. Understanding the development of the vertebrate common ancestor's head skeleton is thus an important step in identifying how different lineages have respectively achieved their many innovations in the head...
November 21, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27884414/low-muscle-mass-is-associated-with-metabolic-syndrome-in-korean-adolescents-the-korea-national-health-and-nutrition-examination-survey-2009-2011
#8
Jeong-Hyeon Kim, Yong Soon Park
Little is known about the relationship between low muscle mass (LMM) and metabolic risk factors in adolescents. We hypothesized that LMM in adolescents is associated with metabolic syndrome (MetS) and its components in Korean adolescents. This cross-sectional study included 1420 participants (749 males and 671 females), aged 12 to 19 years, who participated in the 2009-2011 Korea National Health and Nutrition Examination Surveys. Appendicular skeletal muscle mass was divided by body weight, and any value below the lower quintile of the study population, according to each age and sex category, was considered to represent LMM...
November 3, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27874274/differential-association-between-sarcopenia-and-metabolic-phenotype-in-korean-young-and-older-adults-with-and-without-obesity
#9
You-Cheol Hwang, In-Jin Cho, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
OBJECTIVE: To determine whether sarcopenia was associated with metabolic phenotype in subjects with and without obesity. METHODS: A total of 6,021 participants (2,592 men, 3,429 women) aged 30 to 93 years were assessed using data from the 2009 Korea National Health and Nutrition Examination Survey. Sarcopenia was defined as appendicular skeletal muscle mass divided by weight (%) that is <1 SD below the sex-specific mean for young adults. Metabolically unhealthy was defined as ≥2 components of metabolic syndrome or the presence of hypertension, diabetes, or cardiovascular disease...
November 22, 2016: Obesity
https://www.readbyqxmd.com/read/27866314/factors-associated-with-health-related-quality-of-life-hrqol-in-adults-with-short-stature-skeletal-dysplasias
#10
Nitasha Dhiman, Alia Albaghdadi, Cheryl K Zogg, Meesha Sharma, Julie E Hoover-Fong, Michael C Ain, Adil H Haider
INTRODUCTION: Numerous factors associate with health disparities. The extent to which such factors influence health-related quality of life (HRQOL) among adults with short stature skeletal dysplasias (SD) is unknown. In an effort to update and clarify knowledge about the HRQOL of adults with SD, this study aimed to quantify HRQOL scores relative to the American average and assess whether specific indicators are associated with lower scores. METHODS: Members (>18 years) of Little People of America were invited to complete an online survey assessing HRQOL using the SF-12 supplemented with indicator-specific questions...
November 19, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27864968/taphonomic-effects-of-mechanical-plowing-on-buried-juvenile-sized-remains
#11
Alyssa M Newcomb, James T Pokines, Tara L Moore
Agricultural activity is a worldwide taphonomic process and can present unique challenges in the recovery of buried remains. Previous research has been mostly within the realm of site formation processes of archeological sites utilizing only surface material. This research expands upon the previous research by incorporating the distribution of subsurface material by the use of archeological excavation techniques. An experiment was conducted utilizing juvenile pig (Sus scrofa) skeletons buried in relative anatomical position at two different depths (15 cm below the surface [cmbs] and 22 cmbs)...
November 16, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27858684/a-survey-of-deep-tissue-injury-in-elite-female-wheelchair-basketball-players
#12
Yukiyo Shimizu, Hirotaka Mutsuzaki, Kaori Tachibana, Kenji Tsunoda, Kazushi Hotta, Takashi Fukaya, Eiji Ikeda, Masashi Yamazaki, Yasuyoshi Wadano
OBJECTIVE: To investigate deep tissue injuries (DTIs) in elite female wheelchair basketball players and identify factors associated with their occurrence. METHODS: Study participants were 22 female wheelchair basketball players on the Japanese national team. The sacral and bilateral ischial regions of each participant were examined using ultrasonography to detect DTIs. RESULTS: DTIs were found in 15 players (68.2%). DTIs were more frequent in players with a central nervous system disorder (CNSd) (85...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27837272/body-composition-analysis-by-dxa-dual-x-ray-absorptiometry-in-brazilian-men-normative-data
#13
Marcela Ushida, Marcelo de Medeiros Pinheiro, Charlles Heldan de Moura Castro, Vera Lucia Szejnfeld
Considering ethnic and anthropometric differences, it is important to obtain specific normative data on body composition (BC) for each population. The objectives of this study were to obtain the normative curve for the BC of Brazilian men and to compare them to the North American male population. A total of 403 healthy Brazilian men 20 years and older were included in the study. Data on concomitant diseases and physical activity were investigated using a structured questionnaire. Conditions that could affect lean and fat mass were excluded...
November 11, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27836268/fluoride-enrichment-in-an-alluvial-aquifer-with-its-subsequent-effect-on-human-health-in-birbhum-district-west-bengal-india
#14
D Mondal, S Gupta, D V Reddy, G Dutta
This research work primarily deals with the geochemistry and genesis of fluoride (F(-)) in an alluvial aquifer with an emphasis on prevalence of dental and skeletal fluorosis among the endemic population. Hydrogeochemical outcomes reveal that chemical weathering and ion-exchange phenomena are the two dominant processes that make study area groundwater into NaHCO3 water type. Presence of intercalated zeolite rich sediments (FTotal 412-446 mg/kg) having higher ion-exchange capacity (120-125 meq/100 g) within the aquifer is the source and mobilizing factors of F(-) in groundwater respectively...
November 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/27832208/low-skeletal-muscle-mass-in-the-lower-limbs-is-independently-associated-to-knee-osteoarthritis
#15
Sang Yoon Lee, Hee Joon Ro, Sun G Chung, Si Hyun Kang, Kyung Mook Seo, Don-Kyu Kim
OBJECTIVES: It has been reported that low skeletal muscle mass correlates with knee osteoarthritis in obese individuals. This study aimed to investigate whether lower limb skeletal muscle mass is independently associated with knee osteoarthritis in the general population. MATERIALS AND METHODS: This cross-sectional study used public data from the Fourth and Fifth Korean National Health and Nutrition Examination Survey. Subjects included 4924 community-dwelling adults aged ≥50 years (821 subjects with knee osteoarthritis and 4,103 controls)...
2016: PloS One
https://www.readbyqxmd.com/read/27814714/patient-preferences-for-treatment-of-castration-resistant-prostate-cancer-in-japan-a-discrete-choice-experiment
#16
Hiroji Uemura, Nobuaki Matsubara, Go Kimura, Akito Yamaguchi, Dianne Athene Ledesma, Marco DiBonaventura, Ateesha F Mohamed, Enrique Basurto, Ian McKinnon, Ed Wang, Kristen Concialdi, Aya Narimatsu, Yasuko Aitoku
BACKGROUND: Up to a fifth of patients diagnosed with prostate cancer (PC) will develop castration-resistant prostate cancer (CRPC), which has been associated with a poor prognosis. The aim of this study was to consider the patient perspective as part of the overall treatment decision-making process for CRPC, given that an alignment between patient preference and prescribing has been shown to benefit patient outcomes. This study examines preferences of patients with CRPC in Japan for treatment features associated with treatments like RA-223, abiraterone, and docetaxel and to examine the extent to which treatment preferences may vary between symptomatic and asymptomatic patients...
November 4, 2016: BMC Urology
https://www.readbyqxmd.com/read/27812416/baseline-reef-health-surveys-at-bangka-island-north-sulawesi-indonesia-reveal-new-threats
#17
Massimo Ponti, Francesca Fratangeli, Nicolò Dondi, Marco Segre Reinach, Clara Serra, Michael J Sweet
Worldwide coral reef decline appears to be accompanied by an increase in the spread of hard coral diseases. However, whether this is the result of increased direct and indirect human disturbances and/or an increase in natural stresses remains poorly understood. The provision of baseline surveys for monitoring coral health status lays the foundations to assess the effects of any such anthropogenic and/or natural effects on reefs. Therefore, the objectives of this present study were to provide a coral health baseline in a poorly studied area, and to investigate possible correlations between coral health and the level of anthropogenic and natural disturbances...
2016: PeerJ
https://www.readbyqxmd.com/read/27804161/monoclonal-gammopathy-of-undetermined-significance-mgus-and-smoldering-myeloma-smm-a-practical-guide-to-management
#18
Nicola Maciocia, Ashutosh Wechalekar, Kwee Yong
Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are precursor conditions of symptomatic multiple myeloma (MM). Diagnostic principles are aimed at excluding MM requiring therapy, other conditions associated with paraproteins that may require different management, and risk stratifying patients for the purposes of tailored follow-up and investigation. The International Myeloma Working Group have recently published a revised definition of MM, which singles out a small group of patients with smoldering multiple myeloma who are at very high risk of progression and organ damage; such patients are now included under the definition of MM and recommended to start anti-myeloma treatment...
November 2, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27798733/a-novel-accelerometer-based-method-to-describe-day-to-day-exposure-to-potentially-osteogenic-vertical-impacts-in-older-adults-findings-from-a-multi-cohort-study
#19
K Hannam, K C Deere, A Hartley, E M Clark, J Coulson, A Ireland, C Moss, M H Edwards, E Dennison, T Gaysin, R Cooper, A Wong, J S McPhee, C Cooper, D Kuh, J H Tobias
: This observational study assessed vertical impacts experienced in older adults as part of their day-to-day physical activity using accelerometry and questionnaire data. Population-based older adults experienced very limited high-impact activity. The accelerometry method utilised appeared to be valid based on comparisons between different cohorts and with self-reported activity. INTRODUCTION: We aimed to validate a novel method for evaluating day-to-day higher impact weight-bearing physical activity (PA) in older adults, thought to be important in protecting against osteoporosis, by comparing results between four cohorts varying in age and activity levels, and with self-reported PA levels...
October 31, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27797240/prevalence-and-survival-patterns-of-patients-with-bone-metastasis-from-common-cancers-in-thailand
#20
Areerak Phanphaisarn, Jayantorn Patumanond, Jongkolnee Settakorn, Parunya Chaiyawat, Jeerawan Klangjorhor, Dumnoensun Pruksakorn
BACKGROUND: Bone metastasis is a single condition but presents with various patterns and severities. Skeletal- related events (SREs) deteriorate overall performance status and reduce quality of life. However, guidelines for early detection and management are limited. This study includes a survey of the prevalence of bone metastasis in cases with common cancers in Thailand as well as a focus on survival patterns and SREs. MATERIALS AND METHODS: A retrospective cohort analysis was conducted using a database of the Chiang Mai Cancer Registry and the Musculoskeletal Tumor Registry of the OLARN Center, Chiang Mai University...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
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