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https://www.readbyqxmd.com/read/28277460/aspects-ct-in-acute-ischemia-review-of-current-data
#1
Supada Prakkamakul, Albert J Yoo
The Alberta Stroke Program Early CT score (ASPECTS) is a 10-point semiquantitative topographic scoring system developed for the assessment of early ischemic changes (EICs) on noncontrast-enhanced computed tomography (NCCT) in patients with acute ischemic stroke involving the middle cerebral artery (MCA) territory. One point is subtracted from a total score of 10, if an EIC is present in any part of each of the ASPECTS regions. Higher ASPECTS has been associated with better outcomes and a lower risk of symptomatic intracerebral hemorrhage...
March 8, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28168039/dnm1-mutation-status-sex-and-sterilization-status-of-a-cohort-of-labrador-retrievers-with-and-without-cranial-cruciate-ligament-rupture
#2
Kari J Ekenstedt, Katie M Minor, Aaron K Rendahl, Michael G Conzemius
BACKGROUND: Exercise-induced collapse (EIC) due to DNM1 mutation and rupture of the cranial cruciate ligament are both common syndromes in the Labrador retriever breed. A cohort of 313 Labradors was recruited based on their CCLR status and were subsequently genetically tested for EIC. Epidemiological aspects of the cohort were also described, including sex, sterilization status, and age at sterilization. RESULTS: No sex difference was observed in dogs susceptible to EIC (homozygous for the mutant genotype) compared to dogs not susceptible to EIC (heterozygotes and dogs homozygous for the normal genotype)...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28113005/understanding-the-influence-of-stigma-and-medical-mistrust-on-engagement-in-routine-healthcare-among-black-women-who-have-sex-with-women
#3
Alaina Brenick, Kelly Romano, Christopher Kegler, Lisa A Eaton
PURPOSE: For Black women who have sex with women (BWSW), obtaining routine healthcare can be obstructed by a number of psychosocial barriers, including experiences of stigma, related to both sexual orientation and race, and medical mistrust, both race-based and global. Previous research demonstrates that sexual orientation and race-based stigma, as well as global and race-based medical mistrust, each have a negative impact on health outcomes and engagement in care (EIC) independently...
February 2017: LGBT Health
https://www.readbyqxmd.com/read/28093342/march-2017-editor-in-chief-letter
#4
EDITORIAL
Ed Benzel
No abstract text is available yet for this article.
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28046369/su-g-201-05-comparison-of-different-methods-for-output-verification-of-eleckta-nucletron-s-valencia-skin-applicators
#5
J Barrett, M Yudelev
PURPOSE: The provided output factors for Elekta Nucletron's skin applicators are based on Monte Carlo simulations. These outputs have not been independently verified, and there is no recognized method for output verification of the vendor's applicators. The purpose of this work is to validate the outputs provided by the vendor experimentally. METHODS: Using a Flexitron Ir-192 HDR unit, three experimental methods were employed to determine dose with the 30 mm diameter Valencia applicator: first a gradient method using extrapolation ionization chamber (Far West Technology, EIC-1) measurements in solid water phantom at 3 mm SCD was used...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27906789/radon-and-thoron-in-air-occupational-exposure-study-within-selected-wine-cellars-of-the-western-cape-south-africa-and-associated-annual-effective-doses
#6
R Botha, R T Newman, R Lindsay, P P Maleka
This is the first known study of exposure of Rn (radon) and secondarily Rn (thoron) in-air activity concentrations assessed within nine selected wine cellars in four wine districts of the Western Cape (South Africa) and the associated annual occupational effective doses. E-PERM electret ion chambers (EIC) and RAD-7 α-detectors were used to perform these measurements. The radon in-air levels ranged from 12 ± 4 Bq m to 770 ± 40 Bq m within the nine selected wine cellars. Eight of the nine wine cellars (excluding results from cellar w-6) had a median radon in-air activity concentration of 48 ± 8 Bq m...
January 2017: Health Physics
https://www.readbyqxmd.com/read/27855523/immunomodulatory-and-cellular-anti-oxidant-activities-of-caffeic-ferulic-and-p-coumaric-phenolic-acids-a-structure-activity-relationship-study
#7
Soumaya Kilani-Jaziri, Imen Mokdad-Bzeouich, Mounira Krifa, Nouha Nasr, Kamel Ghedira, Leila Chekir-Ghedira
Many studies have been performed to assess the potential utility of natural products as immunomodulatory agents to enhance host responses and to reduce damage to the human body. To determine whether phenolic compounds (caffeic, ferulic, and p-coumaric acids) have immunomodulatory effects and clarify which types of immune effector cells are stimulated in vitro, we evaluated their effect on splenocyte proliferation and lysosomal enzyme activity. We also investigated the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL)...
November 18, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27818924/identification-and-differentiation-of-panax-ginseng-panax-quinquefolium-and-panax-notoginseng-by-monitoring-multiple-diagnostic-chemical-markers
#8
Wenzhi Yang, Xue Qiao, Kai Li, Jingran Fan, Tao Bo, De-An Guo, Min Ye
To differentiate traditional Chinese medicines (TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng (PG), Panax quinquefolium (PQ) and Panax notoginseng (PN) are used as popular TCM. They contain similar triterpenoid saponins (ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations...
November 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27810455/january-2017-editor-s-letter
#9
EDITORIAL
Ed Benzel
No abstract text is available yet for this article.
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27796460/active-fragments-guided-drug-discovery-and-design-of-selective-tropane-alkaloids-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry-coupled-with-virtual-calculation-and-biological-evaluation
#10
Mengge Zhou, Xiaoyao Ma, Jixue Sun, Guoyu Ding, Qingxin Cui, Yan Miao, Yuanyuan Hou, Min Jiang, Gang Bai
Tropane alkaloids (TAs), rich in the plant of Physochlaina infundibularis Kuang, which is named Huashanshen (HSS) in China, showed good effects on types of spasms. However, no data were collected to explore the relationship between the specificity for muscarinic receptor subtypes and the structures of these TAs. To address this issue, an extracted ion chromatogram (EIC) strategy using ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q/TOF-MS) based on the fragmentation behavior of the TA standards was established to rapidly capture the varied TAs from HSS...
October 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27796459/quantitation-of-human-milk-proteins-and-their-glycoforms-using-multiple-reaction-monitoring-mrm
#11
Jincui Huang, Muchena J Kailemia, Elisha Goonatilleke, Evan A Parker, Qiuting Hong, Rocchina Sabia, Jennifer T Smilowitz, J Bruce German, Carlito B Lebrilla
Human milk plays a substantial role in the child growth, development and determines their nutritional and health status. Despite the importance of the proteins and glycoproteins in human milk, very little quantitative information especially on their site-specific glycosylation is known. As more functions of milk proteins and other components continue to emerge, their fine-detailed quantitative information is becoming a key factor in milk research efforts. The present work utilizes a sensitive label-free MRM method to quantify seven milk proteins (α-lactalbumin, lactoferrin, secretory immunoglobulin A, immunoglobulin G, immunoglobulin M, α1-antitrypsin, and lysozyme) using their unique peptides while at the same time, quantifying their site-specific N-glycosylation relative to the protein abundance...
January 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27756458/lessons-learned-from-developing-an-eradication-investment-case-for-lymphatic-filariasis
#12
REVIEW
R J Kastner, C M Stone, P Steinmann, M Tanner, F Tediosi
In the last few years, the concepts of disease elimination and eradication have again gained consideration from the global health community, with Guinea worm disease (dracunculiasis) on track to become the first parasitic disease to be eradicated. Given the many complex and interlinking issues involved in committing to a disease eradication initiative, such commitments must be based on a solid assessment of a broad range of factors. In this chapter, we discuss the value and implications of undertaking a systematic and fact-based analysis of the overall situation prior to embarking on an elimination or eradication programme...
2016: Advances in Parasitology
https://www.readbyqxmd.com/read/27753243/efficacy-of-knowledge-and-competence-based-training-of-non-physicians-in-the-provision-of-early-infant-male-circumcision-using-the-mogen-clamp-in-rakai-uganda
#13
Edward Nelson Kankaka, Godfrey Kigozi, Daniel Kayiwa, Nehemiah Kighoma, Frederick Makumbi, Teddy Murungi, Dorean Nabukalu, Resty Nampijja, Stephen Watya, Daniel Namuguzi, Fred Nalugoda, Gertrude Nakigozi, David Serwadda, Maria Wawer, Ronald H Gray
OBJECTIVE: To assess acquisition of knowledge and competence in performing Early Infant Male Circumcision (EIMC) by non-physicians trained using a structured curriculum. SUBJECTS AND METHODS: Training in provision of EIMC using the Mogen clamp was conducted for 10 Clinical Officers (COs) and 10 Registered Nurse Midwives (RNMWs), in Rakai, Uganda. Healthy infants whose mothers consented to study participation were assigned to the trainees, each of whom performed at least 10 EIMCs...
April 2017: BJU International
https://www.readbyqxmd.com/read/27749892/quantitation-and-identification-of-intact-major-milk-proteins-for-high-throughput-lc-esi-q-tof-ms-analyses
#14
Delphine Vincent, Aaron Elkins, Mark R Condina, Vilnis Ezernieks, Simone Rochfort
Cow's milk is an important source of proteins in human nutrition. On average, cow's milk contains 3.5% protein. The most abundant proteins in bovine milk are caseins and some of the whey proteins, namely beta-lactoglobulin, alpha-lactalbumin, and serum albumin. A number of allelic variants and post-translationally modified forms of these proteins have been identified. Their occurrence varies with breed, individuality, stage of lactation, and health and nutritional status of the animal. It is therefore essential to have reliable methods of detection and quantitation of these proteins...
2016: PloS One
https://www.readbyqxmd.com/read/27723938/chromatographic-peak-reconstruction-algorithm-to-improve-qualitative-and-quantitative-analysis-of-trace-pesticide-residues
#15
Xiu-Ping Chen, Ruo-Jing Fan, Fang Zhang, Zhong-Quan Li, Bin Xu, Yin-Long Guo
RATIONALE: In order to improve analysis of analytes in trace amounts in a complex matrix, we developed a novel post-processing method, named Chromatographic Peak Reconstruction (CPR), to process the recorded data from gas chromatography time-of-flight mass spectrometry (GC-TOF MS). METHODS: For a trace ion, the relative deviation (δ) between the adjacent scanned mass-to-charge ratios (m/z) was found inversely proportional to its MS peak intensity. Based on this relationship, the thresholds of δ value within the specified intensity segments were estimated by the CPR and used to screen out the suspicious scan-points in the extracted ion chromatographic (EIC) peak...
October 10, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27696125/meniscal-allograft-subluxations-are-not-associated-with-preoperative-native-meniscal-subluxations
#16
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Jae Hyan Kim, Eic Ju Lim
PURPOSE: To determine the relationship between preoperative subluxation of the original menisci and postoperative graft subluxation after lateral meniscal allograft transplantation (MAT). METHODS: Forty patients who underwent isolated lateral MATs in meniscus-deficient knees with a low-grade chondral lesion (≤ICRS grade 2) were assessed. Lateral subluxation of the native meniscus before meniscectomy and those of remaining meniscal tissue before MAT were measured on mid-coronal MRI scans taken at each time point...
September 30, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27662445/a-retrospective-study-to-reveal-factors-associated-with-postoperative-shoulder-imbalance-in-patients-with-adolescent-idiopathic-scoliosis-with-double-thoracic-curve
#17
Choon Sung Lee, Chang Ju Hwang, Eic Ju Lim, Dong-Ho Lee, Jae Hwan Cho
OBJECTIVE Postoperative shoulder imbalance (PSI) is a critical consideration after corrective surgery for a double thoracic curve (Lenke Type 2); however, the radiographic factors related to PSI remain unclear. The purpose of this study was to identify the radiographic factors related to PSI after corrective surgery for adolescent idiopathic scoliosis (AIS) in patients with a double thoracic curve. METHODS This study included 80 patients with Lenke Type 2 AIS who underwent corrective surgery. Patients were grouped according to the presence [PSI(+)] or absence [PSI(-)] of shoulder imbalance at the final follow-up examination (differences of 20, 15, and 10 mm were used)...
December 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27620696/proteomic-profiling-of-human-islets-collected-from-frozen-pancreata-using-laser-capture-microdissection
#18
Lina Zhang, Giacomo Lanzoni, Matteo Battarra, Luca Inverardi, Qibin Zhang
The etiology of Type 1 Diabetes (T1D) remains elusive. Enzymatically isolated and cultured (EIC) islets cannot fully reflect the natural protein composition and disease process of in vivo islets, because of the stress from isolation procedures. In order to study islet protein composition in conditions close to the natural environment, we performed proteomic analysis of EIC islets, and laser capture microdissected (LCM) human islets and acinar tissue from fresh-frozen pancreas sections of three cadaveric donors...
January 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27607414/in-vivo-confocal-microscopy-in-dry-eye-disease-associated-with-chronic-graft-versus-host-disease
#19
Ahmad Kheirkhah, Yureeda Qazi, Michael A Arnoldner, Kunal Suri, Reza Dana
PURPOSE: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host disease (GVHD) using in vivo confocal microscopy (IVCM). METHODS: This study included 54 patients who had moderate to severe DED either associated with (n = 33) or without (n = 21) chronic GVHD. In addition to evaluating clinical parameters of DED, images obtained by laser-scanning IVCM of the central cornea and superior tarsal conjunctiva were analyzed to measure densities of corneal epithelial DCs, corneal subbasal nerves, and conjunctival EICs...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27597563/randomised-trial-of-early-infant-circumcision-performed-by-clinical-officers-and-registered-nurse-midwives-using-the-mogen-clamp-in-rakai-uganda
#20
Edward N Kankaka, Teddy Murungi, Godfrey Kigozi, Frederick Makumbi, Dorean Nabukalu, Stephen Watya, Nehemiah Kighoma, Resty Nampijja, Daniel Kayiwa, Fred Nalugoda, David Serwadda, Maria Wawer, Ronald H Gray
OBJECTIVES: To assess the safety and acceptability of early infant circumcision (EIC) provided by trained clinical officers (COs) and registered nurse midwives (RNMWs) in rural Uganda. SUBJECTS AND METHODS: We conducted a randomised trial of EIC using the Mogen clamp provided by newly trained COs and RNMWs in four health centres in rural Rakai, Uganda. The trial was registered with clinicaltrials.gov # NCT02596282. In all, 501 healthy neonates aged 1-28 days with normal birth weight and gestational age were randomised to COs (n = 256) and RNMWs (n = 245) for EIC, and were followed-up at 1, 7 and 28 days...
January 2017: BJU International
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