keyword
https://read.qxmd.com/read/38511222/sparsentan-ameliorates-glomerular-hypercellularity-and-inflammatory-gene-networks-induced-by-iga1-igg-immune-complexes-in-a-mouse-model-of-iga-nephropathy
#1
JOURNAL ARTICLE
Colin Reily, Zina Moldoveanu, Tiziano Pramparo, Stacy Hall, Zhi-Qiang Huang, Terri Rice, Lea Novak, Radko Komers, Celia P Jenkinson, Jan Novak
IgA nephropathy (IgAN), is characterized by glomerular deposition of immune complexes (IC) consisting of IgA1 with O -glycans deficient in galactose (Gd-IgA1) and Gd-IgA1-specific IgG autoantibodies. These ICs induce kidney injury, and in the absence of disease-specific therapy, up to 40% of IgAN patients progress to kidney failure. IgA1 with its clustered O -glycans is unique to humans, which hampered development of small-animal models of IgAN. Here, we used a model wherein engineered IC (EIC) formed from human Gd-IgA1 and recombinant human IgG autoantibody are injected into nude mice to induce glomerular injury mimicking human IgAN...
March 21, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38499695/posterior-deltoid-sparing-approach-for-displaced-inferior-or-posterior-glenoid-fossa-fractures-technical-note-and-case-series
#2
JOURNAL ARTICLE
Eic Ju Lim, Ho-Seung Jeong, Kook-Jong Kim
Scapular surgery has usually been performed through the posterior Judet approach. This approach allows access to the entire posterior scapular body, but causes significant soft tissue damage and detaches the deltoid muscle. To date, there has been no clinical study of a deltoid-preserving approach to access the joint for displaced postero-inferior glenoid fractures (Ideberg type II or Ib). We describe an easy and less invasive approach to the postero-inferior glenoid fossa.
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38493752/a-lc-ms-based-serum-pharmacochemistry-approach-to-reveal-the-compatibility-features-of-mutual-promotion-assistance-herb-pairs-in-xijiao-dihuang-decoction
#3
JOURNAL ARTICLE
Guisheng Zhou, Yu Zhuang, Yang Dai, Cuihua Chen, Baoping Jiang, Guochun Li, Lian Yin
Xijiao Dihuang decoction (XDT), a famous formula, was usually used to improve the prognosis of patients with blood-heat and blood-stasis syndrome-related diseases. There were some mutual promotion and mutual assistance herb pairs in XDT. However, the exact functions of these herb pairs in the compatibility of XDT were not elucidated due to the lack of appropriate methodologies. Based on the theory of serum pharmacochemistry, a systematic method was established for the qualitative and quantitative analysis of characteristic components in the extracts and drug-containing plasma samples of XDT and its relational mutual promotion/assistance herb pairs...
March 15, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38429655/downregulation-of-smoc1-is-associated-with-progression-of-colorectal-traditional-serrated-adenomas
#4
JOURNAL ARTICLE
Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-O Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, Masahiro Kai, Akio Katanuma, Toshiya Shinohara, Hiroshi Nakase, Tamotsu Sugai, Makoto Osanai, Hiromu Suzuki
BACKGROUND: Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In the present study, we aimed to further characterize the expression of SMOC1 in early colorectal lesions. METHODS: SMOC1 expression was analyzed immunohistochemically in a series of colorectal tumors (n = 199) and adjacent normal colonic tissues (n = 112)...
March 1, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38406006/multiple-epidermal-inclusion-cysts-of-the-female-breast-coexisting-with-fibroadenoma-a-case-report-of-an-incidental-finding
#5
Babatope L Awosusi
This report discusses a case of a 27-year-old female with histopathological examination results of multiple epidermal inclusion cysts (EICs) coexisting with fibroadenoma without any involvement of breast skin. EIC should be considered as one of the differential diagnoses for benign breast lesions. Radiological evaluation, with surgical excision and histopathologic examination, remains the gold standard for the management of EIC. This report aims to increase the level of awareness on the existence of EIC in the breast parenchyma and the possibility of it coexisting with or arising from other benign breast lesions like fibroadenoma...
January 2024: Curēus
https://read.qxmd.com/read/38368169/engineered-immune-cells-as-therapeutics-for-autoimmune-diseases
#6
REVIEW
Moncef Zouali
Current treatment options for autoimmune disease (AID) are essentially immunosuppressive, inhibiting the inflammatory cascade, without curing the disease. Therapeutic monoclonal antibodies (mAbs) that target B cells showed efficacy, emphasizing the importance of B lymphocytes in autoimmune pathogenesis. Treatments that eliminate more potently B cells would open a new therapeutic era for AID. Immune cells can now be bioengineered to express constructs that enable them to specifically eradicate pathogenic B lymphocytes...
February 16, 2024: Trends in Biotechnology
https://read.qxmd.com/read/38345725/exploration-of-tumor-size-measurement-methods-in-preoperative-breast-cancer-assessment-using-whole-body-silicon-photomultiplier-pet-feasibility-and-first-results
#7
JOURNAL ARTICLE
Hiroyuki Kuroda, Takeshi Yoshizako, Nobuhiro Yada, Tomomi Kamimura, Nobuko Yamamoto, Mitsunari Maruyama, Rika Yoshida, Mizuki Fukuda, Yuko Kataoka, Masayuki Itakura, Yasushi Kaji
PURPOSE: Whole-body silicon photomultiplier positron emission tomography (WB SiPM PET) could be used to diagnose breast cancer spread before lumpectomy. We aimed to investigate the method of measuring the tumor size by WB SiPM PET as a basis for diagnosing breast cancer spread in the breast. MATERIALS AND METHODS: We retrospectively reviewed 35 breast cancer lesions in 32 patients who underwent WB SiPM PET/CT in the prone position as preoperative breast cancer examinations from September 2020 to March 2022...
February 12, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38321388/mrmpro-a-web-based-tool-to-improve-the-speed-of-manual-calibration-for-multiple-reaction-monitoring-data-analysis-by-mass-spectrometry
#8
JOURNAL ARTICLE
Ruimin Wang, Hengxuan Jiang, Miaoshan Lu, Junjie Tong, Shaowei An, Jinyin Wang, Changbin Yu
BACKGROUND: As a gold-standard quantitative technique based on mass spectrometry, multiple reaction monitoring (MRM) has been widely used in proteomics and metabolomics. In the analysis of MRM data, as no peak picking algorithm can achieve perfect accuracy, manual inspection is necessary to correct the errors. In large cohort analysis scenarios, the time required for manual inspection is often considerable. Apart from the commercial software that comes with mass spectrometers, the open-source and free software Skyline is the most popular software for quantitative omics...
February 6, 2024: BMC Bioinformatics
https://read.qxmd.com/read/38304202/eic-welcome-embracing-innovation-and-impact-in-medical-imaging-research
#9
EDITORIAL
(no author information available yet)
JMI Editor-in-Chief Bennett A. Landman offers his vision for the new year and the future of the journal.
January 2024: Journal of Medical Imaging
https://read.qxmd.com/read/38303198/-a-case-of-triple-negative-breast-cancer-with-successful-control-of-recurrent-disease-activity-for-more-than-ten-years
#10
JOURNAL ARTICLE
Nobushige Yabe, Rurina Watanuki, Yuko Harada, Aya Kondo, Takako Yanagisawa, Hinako Maeda, Miki Kishi, Takahisa Yoshikawa, Koji Osumi, Noriki Kamiya, Keiichi Sotome, Yoshiyuki Ishii, Hiromitsu Jinno, Tadashi Ikeda, Masahiko Watanabe
A woman in her 70s underwent mastectomy plus axillary lymph node excision(Bt plus Ax)in December 2011 for left breast cancer classified as pT2N1M0, pStage ⅡB. The tumor was identified as an invasive ductal carcinoma(IDC), neural/ glial antigen 2(NG2), pT2(35 mm), INF γ, ly2, v0, g+, f+, s+, extensive intraductal component(EIC)-negative, ICT- positive, NCAT-positive, n(4/18), estrogen receptor(ER)-negative, progesterone receptor(PgR)-negative, human epidermal growth factor receptor 2(HER2)-negative, Ki-67 30-40%...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38233932/participant-comprehension-and-acceptability-of-enhanced-versus-text-only-electronic-informed-consent-an-innovative-qualitative-pilot-study
#11
JOURNAL ARTICLE
Amy Corneli, Summer Starling, Yujung Choi, Jurgis Vosylius, Leanne Madre, Andrew Mackinnon, Pamela Tenaerts
BACKGROUND: The use of electronic informed consent (eIC) in decentralized trials offers a pragmatic approach to enrolling participants across multiple geographic areas. METHODS: Using a randomized, cross-over study design, we conducted a qualitative descriptive evaluation of two eIC approaches-text-only eIC and enhanced eIC-in a mock hypertension Phase III clinical trial. We assessed participant comprehension and acceptability (usability, satisfaction, and eIC preference)...
January 17, 2024: Pilot and Feasibility Studies
https://read.qxmd.com/read/38157816/opes-id-a-software-for-non-targeted-screening-of-organophosphate-esters-based-on-liquid-chromatography-high-resolution-mass-spectrometry
#12
JOURNAL ARTICLE
Yinran Xiong, Jinyue Liu, Jing Yu, Da Chen, Tiantian Li, Fengli Zhou, Ting Wu, Xiaotu Liu, Yiping Du
Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers, presenting a potential threat to the environment and human health. To date, no automatic software exists for the nontargeted screening of OPEs. In this study, OPEs-ID, a user-friendly software, was developed for the identification of OPEs using liquid chromatography-high-resolution mass spectrometry. The main workflow of OPEs-ID included fragments-dependent precursor ion screening, elemental composition determination, extracted ion chromatograms (EIC) comparison, and molecular structure identification via MetFrag strategy...
December 15, 2023: Journal of Hazardous Materials
https://read.qxmd.com/read/38113088/testing-and-practical-implementation-of-a-user-friendly-personalized-and-long-term-electronic-informed-consent-prototype-in-clinical-research-mixed-methods-study
#13
JOURNAL ARTICLE
Evelien De Sutter, David Geerts, Koen Yskout, Stef Verreydt, Pascal Borry, Liese Barbier, Isabelle Huys
BACKGROUND: Over the years, there has been increasing interest in electronic informed consent (eIC) in clinical research. The user-friendliness of an eIC application and its acceptance by stakeholders plays a central role in achieving successful implementation. OBJECTIVE: This study aims to identify insights for the design and implementation of a user-friendly, personalized, and long-term eIC application based on a usability study with (potential) research participants and semistructured interviews with stakeholders on the practical integration of such an application into their daily practice...
December 19, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/38099736/epithelial-immune-cell-response-to-initial-soft-contact-lens-wear-in-the-human-corneal-and-conjunctival-epithelium
#14
JOURNAL ARTICLE
Rabia Mobeen, Fiona Stapleton, Cecilia Chao, Mandy C Huynh, Yee S Phoebe Wong, Thomas Naduvilath, Blanka Golebiowski
PURPOSE: The purpose of this study was to assess the immediate ocular immune response to soft contact lens (CL) wear by examining presumed epithelial immune cell (EIC) density and morphology at the central, peripheral, limbal cornea, and conjunctiva. METHODS: Fifty-four participants naïve to CL wear (mean age = 24.8 ± 9.8 years, 44% female participants), were examined using in vivo confocal microscopy at baseline and after 2 hours of CL wear (1-Day ACUVUE MOIST)...
December 1, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38071769/combination-of-in-silico-prediction-and-convolutional-neural-network-framework-for-targeted-screening-of-metabolites-from-lc-hrms-fingerprints-a-case-study-of-pericarpium-citri-reticulatae-fructusaurantii
#15
JOURNAL ARTICLE
Jun Zeng, Yaping Li, Chuanlin Wang, Sheng Fu, Min He
In this study, a novel approach is introduced, merging in silico prediction with a Convolutional Neural Network (CNN) framework for the targeted screening of in vivo metabolites in Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) fingerprints. Initially, three predictive tools, supplemented by literature, identify potential metabolites for target prototypes derived from Traditional Chinese Medicines (TCMs) or functional foods. Subsequently, a CNN is developed to minimize false positives from CWT-based peak detection...
December 5, 2023: Talanta
https://read.qxmd.com/read/38021199/extensive-intraductal-component-as-a-factor-determining-local-recurrence-of-breast-cancer-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Nuanphan Polchai, Sarun Thongvitokomarn
BACKGROUND: Breast-conserving surgery and mastectomy are standard surgical options for breast cancer. However, some patients experience a local recurrence after the operation. Many factors have been identified as a risk of local recurrence. Extensive intraductal component (EIC) was found as one of the major risks of the recurrence. Nevertheless, there were neither any systematic reviews nor controlled trials focused on EIC. This study aims to identify the impact of EIC on the local recurrence of breast cancer...
October 30, 2023: Gland Surgery
https://read.qxmd.com/read/37991143/recanalization-status-and-temporal-evolution-of-early-ischemic-changes-following-stroke-thrombectomy
#17
JOURNAL ARTICLE
Pekka Virtanen, Liisa Tomppo, Georgios Georgiopoulos, Nina Brandstack, Erno Peltola, Tatu Kokkonen, Kimmo Lappalainen, Antti Korvenoja, Daniel Strbian
INTRODUCTION: Present-day computer tomography (CT) scanners have excellent spatial resolution and signal-to-noise ratio and are instrumental detecting early ischemic changes (EIC) in brain. We assessed the temporal changes of EIC based on the recanalization status after thrombectomy. PATIENTS AND METHODS: The cohort comprises consecutive patients with acute ischemic stroke in anterior circulation treated with thrombectomy in tertiary referral hospital. All baseline and follow-up scans were screened for any ischemic changes and further classified using Alberta Stroke Program Early CT Score (ASPECTS)...
November 22, 2023: European Stroke Journal
https://read.qxmd.com/read/37925552/surgical-outcomes-of-acetabular-fracture-of-elderly-patients-with-superomedial-dome-impaction
#18
JOURNAL ARTICLE
Eic Ju Lim, Hyun-Chul Shon, Jae-Young Yang, Joosuk Ahn, Jung Jae Kim, Ji Wan Kim
This study aimed to investigate the outcomes of elderly acetabular fractures according to the reduction of impacted dome fragments. A retrospective cohort study was performed in two institutions. Fifty-four patients aged ≥ 60 years with acetabular fractures were enrolled. Data for dome impaction and postoperative reduction was collected. Patients were divided into the good reduction group (displacement ≤ 3 mm) and poor reduction group (displacement > 3 mm)...
November 4, 2023: Scientific Reports
https://read.qxmd.com/read/37853410/an-adapted-algorithm-for-patient-engagement-in-care-for-young-people-living-with-perinatal-hiv-in-england
#19
JOURNAL ARTICLE
Marthe Le Prevost, Deborah Ford, Siobhan Crichton, Caroline Foster, Alasdair Bamford, Ali Judd
BACKGROUND: Evidence suggests that engagement in care (EIC) may be worse in young people living with perinatal HIV (YPLPHIV) compared to adults or children living with HIV. We took a published EIC algorithm for adults with HIV, which takes patients' clinical scenarios into account, and adapted it for use in YPLPHIV in England, to measure their EIC. METHODS: The adult algorithm predicts when in the next 6 months the next clinic visit should be scheduled, based on routinely collected clinical indicators at the current visit...
October 18, 2023: BMC Health Services Research
https://read.qxmd.com/read/37841354/epidermal-inclusion-cyst-formation-late-complication-of-carpal-tunnel-release
#20
Srdjan Kamenko, Holden Richards, Russell Jared Madsen, Shiliang Chang
Background  Epidermal inclusion cysts (EIC) are epidermally lined, keratin containing cysts which occur when keratinizing epithelium becomes imbedded in deeper subcutaneous tissue, usually following penetrating trauma, or, rarely, surgery. We describe a case of an EIC presenting as a late complication following open carpal tunnel release (CTR). Case Description  A 64-year-old woman with a history of left open CTR 17 years prior presented to our institution with unprovoked left palmar pain, swelling, and fluctuance...
October 2023: Journal of Wrist Surgery
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