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https://www.readbyqxmd.com/read/27855523/immunomodulatory-and-cellular-anti-oxidant-activities-of-caffeic-ferulic-and-p-coumaric-phenolic-acids-a-structure-activity-relationship-study
#1
Soumaya Kilani-Jaziri, Imen Mokdad-Bzeouich, Mounira Krifa, Nouha Nasr, Kamel Ghedira, Leila Chekir-Ghedira
Many studies have been performed to assess the potential utility of natural products as immunomodulatory agents to enhance host responses and to reduce damage to the human body. To determine whether phenolic compounds (caffeic, ferulic, and p-coumaric acids) have immunomodulatory effects and clarify which types of immune effector cells are stimulated in vitro, we evaluated their effect on splenocyte proliferation and lysosomal enzyme activity. We also investigated the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL)...
November 18, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27818924/identification-and-differentiation-of-panax-ginseng-panax-quinquefolium-and-panax-notoginseng-by-monitoring-multiple-diagnostic-chemical-markers
#2
Wenzhi Yang, Xue Qiao, Kai Li, Jingran Fan, Tao Bo, De-An Guo, Min Ye
To differentiate traditional Chinese medicines (TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng (PG), Panax quinquefolium (PQ) and Panax notoginseng (PN) are used as popular TCM. They contain similar triterpenoid saponins (ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations...
November 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27810455/january-2017-eic-letter
#3
EDITORIAL
Ed Benzel
No abstract text is available yet for this article.
October 31, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27796460/active-fragments-guided-drug-discovery-and-design-of-selective-tropane-alkaloids-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry-coupled-with-virtual-calculation-and-biological-evaluation
#4
Mengge Zhou, Xiaoyao Ma, Jixue Sun, Guoyu Ding, Qingxin Cui, Yan Miao, Yuanyuan Hou, Min Jiang, Gang Bai
Tropane alkaloids (TAs), rich in the plant of Physochlaina infundibularis Kuang, which is named Huashanshen (HSS) in China, showed good effects on types of spasms. However, no data were collected to explore the relationship between the specificity for muscarinic receptor subtypes and the structures of these TAs. To address this issue, an extracted ion chromatogram (EIC) strategy using ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q/TOF-MS) based on the fragmentation behavior of the TA standards was established to rapidly capture the varied TAs from HSS...
October 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27796459/quantitation-of-human-milk-proteins-and-their-glycoforms-using-multiple-reaction-monitoring-mrm
#5
Jincui Huang, Muchena J Kailemia, Elisha Goonatilleke, Evan A Parker, Qiuting Hong, Rocchina Sabia, Jennifer T Smilowitz, J Bruce German, Carlito B Lebrilla
Human milk plays a substantial role in the child growth, development and determines their nutritional and health status. Despite the importance of the proteins and glycoproteins in human milk, very little quantitative information especially on their site-specific glycosylation is known. As more functions of milk proteins and other components continue to emerge, their fine-detailed quantitative information is becoming a key factor in milk research efforts. The present work utilizes a sensitive label-free MRM method to quantify seven milk proteins (α-lactalbumin, lactoferrin, secretory immunoglobulin A, immunoglobulin G, immunoglobulin M, α1-antitrypsin, and lysozyme) using their unique peptides while at the same time, quantifying their site-specific N-glycosylation relative to the protein abundance...
October 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27756458/lessons-learned-from-developing-an-eradication-investment-case-for-lymphatic-filariasis
#6
R J Kastner, C M Stone, P Steinmann, M Tanner, F Tediosi
In the last few years, the concepts of disease elimination and eradication have again gained consideration from the global health community, with Guinea worm disease (dracunculiasis) on track to become the first parasitic disease to be eradicated. Given the many complex and interlinking issues involved in committing to a disease eradication initiative, such commitments must be based on a solid assessment of a broad range of factors. In this chapter, we discuss the value and implications of undertaking a systematic and fact-based analysis of the overall situation prior to embarking on an elimination or eradication programme...
2016: Advances in Parasitology
https://www.readbyqxmd.com/read/27753243/efficacy-of-knowledge-and-competence-based-training-of-non-physicians-in-the-provision-of-early-infant-male-circumcision-using-the-mogen-clamp-in-rakai-uganda
#7
Edward Nelson Kankaka, Godfrey Kigozi, Daniel Kayiwa, Nehemiah Kighoma, Frederick Makumbi, Teddy Murungi, Dorean Nabukalu, Resty Nampijja, Stephen Watya, Daniel Namuguzi, Fred Nalugoda, Gertrude Nakigozi, David Serwadda, Maria Wawer, Ronald H Gray
OBJECTIVE: To assess acquisition of knowledge and competence in performing Early Infant Male Circumcision (EIMC) by non-physicians trained using a structured curriculum. SUBJECTS AND METHODS: Training in provision of EIMC using the Mogen clamp was conducted for 10 Clinical Officers (COs) and 10 Registered Nurse Midwives (RNMWs), in Rakai, Uganda. Healthy infants whose mothers consented to study participation were assigned to the trainees, each of whom performed at least 10 EIMCs...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27749892/quantitation-and-identification-of-intact-major-milk-proteins-for-high-throughput-lc-esi-q-tof-ms-analyses
#8
Delphine Vincent, Aaron Elkins, Mark R Condina, Vilnis Ezernieks, Simone Rochfort
Cow's milk is an important source of proteins in human nutrition. On average, cow's milk contains 3.5% protein. The most abundant proteins in bovine milk are caseins and some of the whey proteins, namely beta-lactoglobulin, alpha-lactalbumin, and serum albumin. A number of allelic variants and post-translationally modified forms of these proteins have been identified. Their occurrence varies with breed, individuality, stage of lactation, and health and nutritional status of the animal. It is therefore essential to have reliable methods of detection and quantitation of these proteins...
2016: PloS One
https://www.readbyqxmd.com/read/27723938/chromatographic-peak-reconstruction-algorithm-to-improve-qualitative-and-quantitative-analysis-of-trace-pesticide-residues
#9
Xiu-Ping Chen, Ruo-Jing Fan, Fang Zhang, Zhong-Quan Li, Bin Xu, Yin-Long Guo
RATIONALE: In order to improve analysis of analytes in trace amounts in a complex matrix, we developed a novel post-processing method, named Chromatographic Peak Reconstruction (CPR), to process the recorded data from gas chromatography time-of-flight mass spectrometry (GC-TOF MS). METHODS: For a trace ion, the relative deviation (δ) between the adjacent scanned mass-to-charge ratios (m/z) was found inversely proportional to its MS peak intensity. Based on this relationship, the thresholds of δ value within the specified intensity segments were estimated by the CPR and used to screen out the suspicious scan-points in the extracted ion chromatographic (EIC) peak...
October 10, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27696125/meniscal-allograft-subluxations-are-not-associated-with-preoperative-native-meniscal-subluxations
#10
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Jae Hyan Kim, Eic Ju Lim
PURPOSE: To determine the relationship between preoperative subluxation of the original menisci and postoperative graft subluxation after lateral meniscal allograft transplantation (MAT). METHODS: Fourteen patients who underwent isolated lateral MATs in meniscus-deficient knees with a low-grade chondral lesion (≤ICRS grade 2) were assessed. Lateral subluxation of the native meniscus before meniscectomy and those of remaining meniscal tissue before MAT were measured on mid-coronal MRI scans taken at each time point...
September 30, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27662445/a-retrospective-study-to-reveal-factors-associated-with-postoperative-shoulder-imbalance-in-patients-with-adolescent-idiopathic-scoliosis-with-double-thoracic-curve
#11
Choon Sung Lee, Chang Ju Hwang, Eic Ju Lim, Dong-Ho Lee, Jae Hwan Cho
OBJECTIVE Postoperative shoulder imbalance (PSI) is a critical consideration after corrective surgery for a double thoracic curve (Lenke Type 2); however, the radiographic factors related to PSI remain unclear. The purpose of this study was to identify the radiographic factors related to PSI after corrective surgery for adolescent idiopathic scoliosis (AIS) in patients with a double thoracic curve. METHODS This study included 80 patients with Lenke Type 2 AIS who underwent corrective surgery. Patients were grouped according to the presence [PSI(+)] or absence [PSI(-)] of shoulder imbalance at the final follow-up examination (differences of 20, 15, and 10 mm were used)...
December 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27620696/proteomic-profiling-of-human-islets-collected-from-frozen-pancreata-using-laser-capture-microdissection
#12
Lina Zhang, Giacomo Lanzoni, Matteo Battarra, Luca Inverardi, Qibin Zhang
: The etiology of Type 1 Diabetes (T1D) remains elusive. Enzymatically isolated and cultured (EIC) islets cannot fully reflect the natural protein composition and disease process of in vivo islets, because of the stress from isolation procedures. In order to study islet protein composition in conditions close to the natural environment, we performed proteomic analysis of EIC islets, and laser capture microdissected (LCM) human islets and acinar tissue from fresh-frozen pancreas sections of three cadaveric donors...
January 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27607414/in-vivo-confocal-microscopy-in-dry-eye-disease-associated-with-chronic-graft-versus-host-disease
#13
Ahmad Kheirkhah, Yureeda Qazi, Michael A Arnoldner, Kunal Suri, Reza Dana
PURPOSE: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host disease (GVHD) using in vivo confocal microscopy (IVCM). METHODS: This study included 54 patients who had moderate to severe DED either associated with (n = 33) or without (n = 21) chronic GVHD. In addition to evaluating clinical parameters of DED, images obtained by laser-scanning IVCM of the central cornea and superior tarsal conjunctiva were analyzed to measure densities of corneal epithelial DCs, corneal subbasal nerves, and conjunctival EICs...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27597563/randomised-trial-of-early-infant-circumcision-performed-by-clinical-officers-and-registered-nurse-midwives-using-the-mogen-clamp-in-rakai-uganda
#14
Edward N Kankaka, Teddy Murungi, Godfrey Kigozi, Frederick Makumbi, Dorean Nabukalu, Stephen Watya, Nehemiah Kighoma, Resty Nampijja, Daniel Kayiwa, Fred Nalugoda, David Serwadda, Maria Wawer, Ronald H Gray
OBJECTIVES: To assess the safety and acceptability of early infant circumcision (EIC) provided by trained clinical officers (COs) and registered nurse midwives (RNMWs) in rural Uganda. SUBJECTS AND METHODS: We conducted a randomised trial of EIC using the Mogen clamp provided by newly trained COs and RNMWs in four health centres in rural Rakai, Uganda. The trial was registered with clinicaltrials.gov # NCT02596282. In all, 501 healthy neonates aged 1-28 days with normal birth weight and gestational age were randomised to COs (n = 256) and RNMWs (n = 245) for EIC, and were followed-up at 1, 7 and 28 days...
September 6, 2016: BJU International
https://www.readbyqxmd.com/read/27561181/profiling-and-identification-of-metabolites-of-isorhynchophylline-in-rats-by-ultra-high-performance-liquid-chromatography-and-linear-ion-trap-orbitrap-mass-spectrometry
#15
Jianwei Wang, Peng Qi, Jinjun Hou, Yao Shen, Bingpeng Yan, Qirui Bi, RuiHong Feng, Xiaojian Shi, Min Yang, Wanying Wu, De-An Guo
The searching of potentially bioactive metabolites in the biological body is an interesting and meaningful work for the drug study. However, the structural clarification of possible metabolites is one of the most challenging tasks in drug metabolism studies because of the variety of metabolic reactions and complexity of metabolites in vivo. Here, an ultra high performance liquid chromatography/linear ion trap-Orbitrap mass spectrometry (U-HPLC/LTQ-Orbitrap-MS) with combination of data post-processing techniques, including extracted ion chromatogram (EIC) and multiple mass defect filters (MMDF), was established for profiling and identification of metabolites of isorhynchophylline (IR) in vivo and in vitro, and the possible metabolic pathways were subsequently proposed after the oral dose of 20mg/kg; A total of 47 metabolites of IR were tentatively identified, including 47, 21, 18, and 25 metabolites in rat urine, plasma, liver and rat liver microsomes (RLM) samples, respectively...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27544822/the-st-gallen-surrogate-classification-for-breast-cancer-subtypes-successfully-predicts-tumor-presenting-features-nodal-involvement-recurrence-patterns-and-disease-free-survival
#16
Ines Vasconcelos, Afsana Hussainzada, Stefan Berger, Ellen Fietze, Jörg Linke, Friederike Siedentopf, Winfried Schoenegg
AIMS: To evaluate how the St. Gallen intrinsic subtype classification for breast cancer surrogates predicts disease features, recurrence patterns and disease free survival. MATERIALS AND METHODS: Subtypes were classified by immunohistochemical staining according to St. Gallen subtypes classification in a 5-tyre system: luminal A, luminal B HER2-neu negative, luminal B HER2-neu positive, HER2-neu non luminal or basal-like. Data were obtained from the records of patients with invasive breast cancer treated at our institution...
October 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27535232/topic-model-based-mass-spectrometric-data-analysis-in-cancer-biomarker-discovery-studies
#17
Minkun Wang, Tsung-Heng Tsai, Cristina Di Poto, Alessia Ferrarini, Guoqiang Yu, Habtom W Ressom
BACKGROUND: A fundamental challenge in quantitation of biomolecules for cancer biomarker discovery is owing to the heterogeneous nature of human biospecimens. Although this issue has been a subject of discussion in cancer genomic studies, it has not yet been rigorously investigated in mass spectrometry based proteomic and metabolomic studies. Purification of mass spectometric data is highly desired prior to subsequent analysis, e.g., quantitative comparison of the abundance of biomolecules in biological samples...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27535219/development-and-application-of-a-new-measure-of-engagement-in-out-patient-hiv-care
#18
A R Howarth, F M Burns, V Apea, S Jose, T Hill, V C Delpech, A Evans, C H Mercer, S Michie, S Morris, M Sachikonye, C Sabin
OBJECTIVES: Commonly used measures of engagement in HIV care do not take into account that the frequency of attendance is related to changes in treatment and health status. This study developed a new measure of engagement in care (EIC) incorporating clinical factors. METHODS: We conducted semi-structured interviews with eight HIV physicians to identify factors associated with the timing of patients' next scheduled appointments. These factors informed the development of an algorithm to classify each month of follow-up as "in care" (on or before the time of the next expected attendance) or "out of care" (after the time of the next expected attendance)...
August 18, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27489728/deeper-insight-into-maternal-genetic-assessments-and-demographic-history-for-egyptian-indigenous-chicken-populations-using-mtdna-analysis
#19
Marwa A Eltanany, Shabaan A Hemeda
This study principally sought to reveal the demographic expansion of Egyptian indigenous chickens (EIC) using representative breeds: Sinai (North), Fayoumi (Middle) and Dandarawi (South) of Egypt as well as to deeply clarify their genetic diversity, possible matrilineal origin and dispersal routes. A total of 33 partial mitochondrial DNA sequences were generated from EIC and compared with a worldwide reference dataset of 1290 wild and domestic chicken sequences. Study populations had 12 polymorphic variable sites and 7 haplotypes...
September 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27476686/october-2016-editor-in-chief-letter
#20
Ed Benzel
No abstract text is available yet for this article.
October 2016: World Neurosurgery
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