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https://www.readbyqxmd.com/read/29064000/-1-h-15-n-13-c-backbone-resonance-assignment-of-the-c-terminal-domain-of-enzyme-i-from-thermoanaerobacter-tengcongensis
#1
Rochelle Rea Dotas, Vincenzo Venditti
Phosphoenolpyruvate binding to the C-terminal domain (EIC) of enzyme I of the bacterial phosphotransferase system (PTS) initiates a phosphorylation cascade that results in sugar translocation across the cell membrane and controls a large number of essential pathways in bacterial metabolism. EIC undergoes an expanded to compact conformational equilibrium that is regulated by ligand binding and determines the phosphorylation state of the overall PTS. Here, we report the backbone (1)H, (15)N and (13)C chemical shift assignments of the 70 kDa EIC dimer from the thermophilic bacterium Thermoanaerobacter tengcongensis...
October 24, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29056361/compensatory-plasticity-in-diaphragm-and-intercostal-muscle-utilization-in-a-rat-model-of-als
#2
Yasin B Seven, Nicole L Nichols, Mia N Kelly, Orinda R Hobson, Irawan Satriotomo, Gordon S Mitchell
In SOD1(G93A) transgenic rat model of ALS, breathing capacity is preserved until late in disease progression despite profound respiratory motor neuron (MN) cell death. To explore mechanisms preserving breathing capacity, we assessed inspiratory EMG activity in diaphragm and external intercostal T2 (EIC2) and T5 (EIC5) muscles in anesthetized SOD1(G93A) rats at disease end-stage (20% decrease in body mass). We hypothesized that despite significant phrenic motor neuron loss and decreased phrenic nerve activity, diaphragm electrical activity and trans-diaphragmatic pressure (Pdi) are maintained to sustain ventilation...
October 19, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28938737/complex-catsper-dependent-and-independent-ca2-i-signalling-in-human-spermatozoa-induced-by-follicular-fluid
#3
Sean G Brown, Sarah Costello, Mark C Kelly, Mythili Ramalingam, Ellen Drew, Stephen J Publicover, Christopher L R Barratt, Sarah Martins Da Silva
STUDY QUESTION: Does progesterone in human follicular fluid (hFF) activate CatSper and do other components of hFF modulate this effect and/or contribute separately to hFF-induced Ca2+ signaling? SUMMARY ANSWER: hFF potently stimulates CatSper and increases [Ca2+]i, primarily due to high concentrations of progesterone, however, other components of hFF also contribute to [Ca2+]i signaling, including modulation of CatSper channel activity and inhibition of [Ca2+]i oscillations...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28859592/dr-abbott-leaves-jospt-to-focus-on-research-program
#4
(no author information available yet)
The Board of Directors of JOSPT(®), Inc, d/b/a Movement Science Media (MSM), has accepted the resignation of J. Haxby Abbott, PhD, DPT, FNZCP, as Editor-in-Chief (EIC) of the Journal of Orthopaedic & Sports Physical Therapy, effective December 31, 2017. Dr Abbott is leaving JOSPT to focus on his research program and to spend time with his young family. The Board expects to appoint an interim EIC and to begin a search for Dr Abbott's successor. J Orthop Sports Phys Ther 2017;47(9):587. doi:10.2519/jospt.2017...
September 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28829318/event-based-impulsive-control-of-continuous-time-dynamic-systems-and-its-application-to-synchronization-of-memristive-neural-networks
#5
Wei Zhu, Dandan Wang, Lu Liu, Gang Feng
This paper investigates exponential stabilization of continuous-time dynamic systems (CDSs) via event-based impulsive control (EIC) approaches, where the impulsive instants are determined by certain state-dependent triggering condition. The global exponential stability criteria via EIC are derived for nonlinear and linear CDSs, respectively. It is also shown that there is no Zeno-behavior for the concerned closed loop control system. In addition, the developed event-based impulsive scheme is applied to the synchronization problem of master and slave memristive neural networks...
August 18, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28752757/detailed-investigation-and-comparison-of-the-xcms-and-mzmine-2-chromatogram-construction-and-chromatographic-peak-detection-methods-for-preprocessing-mass-spectrometry-metabolomics-data
#6
Owen D Myers, Susan J Sumner, Shuzhao Li, Stephen Barnes, Xiuxia Du
XCMS and MZmine 2 are two widely used software packages for preprocessing untargeted LC/MS metabolomics data. Both construct extracted ion chromatograms (EICs) and detect peaks from the EICs, the first two steps in the data preprocessing workflow. While both packages have performed admirably in peak picking, they also detect a problematic number of false positive EIC peaks and can also fail to detect real EIC peaks. The former and latter translate downstream into spurious and missing compounds and present significant limitations with most existing software packages that preprocess untargeted mass spectrometry metabolomics data...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28752754/one-step-forward-for-reducing-false-positive-and-false-negative-compound-identifications-from-mass-spectrometry-metabolomics-data-new-algorithms-for-constructing-extracted-ion-chromatograms-and-detecting-chromatographic-peaks
#7
Owen D Myers, Susan J Sumner, Shuzhao Li, Stephen Barnes, Xiuxia Du
False positive and false negative peaks detected from extracted ion chromatograms (EIC) are an urgent problem with existing software packages that preprocess untargeted liquid or gas chromatography-mass spectrometry metabolomics data because they can translate downstream into spurious or missing compound identifications. We have developed new algorithms that carry out the sequential construction of EICs and detection of EIC peaks. We compare the new algorithms to two popular software packages XCMS and MZmine 2 and present evidence that these new algorithms detect significantly fewer false positives...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28696781/early-intervention-of-cystic-fibrosis-pulmonary-exacerbations-based-on-home-monitoring-eice-through-the-looking-glass
#8
Scott C Bell
No abstract text is available yet for this article.
July 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28621737/comprehensive-identification-of-guan-xin-shu-tong-capsule-via-a-mass-defect-and-fragment-filtering-approach-by-high-resolution-mass-spectrometry-in-vitro-and-in-vivo-study
#9
Xun Gao, Jingqing Mu, Qing Li, Shaoyi Guan, Ran Liu, Yiyang Du, Huifen Zhang, Kaishun Bi
The Guan-Xin-Shu-Tong capsule (GXSTC) is a well-known traditional Chinese medicine that is used for the treatment of coronary heart disease. Despite its common use in China, basic pharmacological research on its active components is limited. A comprehensive analytical method using quadrupole-time-of-flight mass spectrometry (Q-TOF/MS), specifically with the Triple TOF 5600 platform, was developed to characterize the compounds in the GXSTC powder itself (in vitro) as well as the active components in healthy and heart disease model rats after its oral administration (in vivo)...
June 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28608719/home-monitoring-of-patients-with-cystic-fibrosis-to-identify-and-treat-acute-pulmonary-exacerbations-eice-study-results
#10
Noah Lechtzin, Nicole Mayer-Hamblett, Natalie E West, Sarah Allgood, Ellen Wilhelm, Umer Khan, Moira L Aitken, Bonnie W Ramsey, Michael P Boyle, Peter J Mogayzel, Ronald L Gibson, David Orenstein, Carlos Milla, John P Clancy, Veena Antony, Christopher H Goss
RATIONALE: Individuals with cystic fibrosis (CF) experience frequent acute pulmonary exacerbations, which lead to decreased lung function and reduced quality of life. OBJECTIVES: The goal of this study was to determine if an intervention directed toward early detection of pulmonary exacerbations using home spirometry and symptom monitoring would result in slower decline in lung function than in control subjects. METHODS: We conducted a multicenter, randomized trial at 14 CF centers with subjects at least 14 years old...
November 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28561755/rapid-screening-and-identification-of-diterpenoids-in-tinospora-sinensis-based-on-high-performance-liquid-chromatography-coupled-with-linear-ion-trap-orbitrap-mass-spectrometry
#11
Lu-Lu Xu, Feng-Xia Guo, Sen-Sen Chi, Zi-Jian Wang, Yan-Yan Jiang, Bin Liu, Jia-Yu Zhang
Diterpenoids are considered the major active compounds in Tinospora sinensis in virtue of their special structures and activities. Herein, an analytical method was developed for rapid screening and identification of diterpenoids in T. sinensis using high-performmance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (HPLC-LTQ-Orbitrap) in negative ion mode. Two diterpenoid reference standards were first analyzed to obtain their characteristic ESI-MS/MS fragmentation patterns. Then, based on the extracted ion chromatogram (EIC) data-mining method and characteristic fragmentation pathways analysis, diterpenoids in T...
May 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28436401/effects-of-amplitude-and-phase-duration-modification-on-electrically-induced-contraction-force-and-discomfort
#12
Shmuel Springer, Maxim Shapiro
BACKGROUND: Neuromuscular electrical stimulation (NMES) is commonly used in rehabilitation. However, the optimal combination of phase-duration and amplitude for enhancing motor output is not yet resolved. OBJECTIVE: To test the effects of increasing phase-duration and amplitude on isometric knee extension force and discomfort, while controlling the effects of electrode-skin resistance and body mass index (BMI). METHODS: Twenty-one healthy volunteers participated in the study...
August 9, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28385557/changes-in-hormonal-levels-associated-with-enforced-interval-copulation-and-anxiety-in-sexually-inexperienced-and-experienced-male-rats
#13
Tzintli Meraz-Medina, Marisela Hernández-González, Herlinda Bonilla-Jaime, Miguel Angel Guevara, Leopoldo Flores-Mancilla, Rosa María Vigueras-Villaseñor, Marcela Arteaga-Silva
This study evaluated the effect of sexual experience on anxiety and hormonal levels associated with the performance of sexual behavior. Two groups of male rats, one with, the second without, sexual experience, were exposed to four different copulatory conditions: ad libitum copulation until ejaculation (ADC-E); enforced interval copulation until ejaculation (EIC-E); ad libitum copulation up to 3 intromissions (ADC-3I); and enforced interval copulation up to 3 intromissions (EIC-E3I). At the end of each condition the animals were subjected to an open-field test to measure anxiety, before being sacrificed to measure corticosterone (CORT) and testosterone (T) levels...
April 4, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28383950/multilevel-factorial-designs-with-experiment-induced-clustering
#14
Inbal Nahum-Shani, John J Dziak, Linda M Collins
Factorial experimental designs have many applications in the behavioral sciences. In the context of intervention development, factorial experiments play a critical role in building and optimizing high-quality, multicomponent behavioral interventions. One challenge in implementing factorial experiments in the behavioral sciences is that individuals are often clustered in social or administrative units and may be more similar to each other than to individuals in other clusters. This means that data are dependent within clusters...
April 6, 2017: Psychological Methods
https://www.readbyqxmd.com/read/28277460/aspects-ct-in-acute-ischemia-review-of-current-data
#15
REVIEW
Supada Prakkamakul, Albert J Yoo
The Alberta Stroke Program Early CT score (ASPECTS) is a 10-point semiquantitative topographic scoring system developed for the assessment of early ischemic changes (EICs) on noncontrast-enhanced computed tomography (NCCT) in patients with acute ischemic stroke involving the middle cerebral artery (MCA) territory. One point is subtracted from a total score of 10, if an EIC is present in any part of each of the ASPECTS regions. Higher ASPECTS has been associated with better outcomes and a lower risk of symptomatic intracerebral hemorrhage...
June 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28168039/dnm1-mutation-status-sex-and-sterilization-status-of-a-cohort-of-labrador-retrievers-with-and-without-cranial-cruciate-ligament-rupture
#16
Kari J Ekenstedt, Katie M Minor, Aaron K Rendahl, Michael G Conzemius
BACKGROUND: Exercise-induced collapse (EIC) due to DNM1 mutation and rupture of the cranial cruciate ligament are both common syndromes in the Labrador retriever breed. A cohort of 313 Labradors was recruited based on their CCLR status and were subsequently genetically tested for EIC. Epidemiological aspects of the cohort were also described, including sex, sterilization status, and age at sterilization. RESULTS: No sex difference was observed in dogs susceptible to EIC (homozygous for the mutant genotype) compared to dogs not susceptible to EIC (heterozygotes and dogs homozygous for the normal genotype)...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28113005/understanding-the-influence-of-stigma-and-medical-mistrust-on-engagement-in-routine-healthcare-among-black-women-who-have-sex-with-women
#17
Alaina Brenick, Kelly Romano, Christopher Kegler, Lisa A Eaton
PURPOSE: For Black women who have sex with women (BWSW), obtaining routine healthcare can be obstructed by a number of psychosocial barriers, including experiences of stigma, related to both sexual orientation and race, and medical mistrust, both race-based and global. Previous research demonstrates that sexual orientation and race-based stigma, as well as global and race-based medical mistrust, each have a negative impact on health outcomes and engagement in care (EIC) independently...
February 2017: LGBT Health
https://www.readbyqxmd.com/read/28093342/march-2017-editor-in-chief-letter
#18
EDITORIAL
Ed Benzel
No abstract text is available yet for this article.
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28046369/su-g-201-05-comparison-of-different-methods-for-output-verification-of-eleckta-nucletron-s-valencia-skin-applicators
#19
J Barrett, M Yudelev
PURPOSE: The provided output factors for Elekta Nucletron's skin applicators are based on Monte Carlo simulations. These outputs have not been independently verified, and there is no recognized method for output verification of the vendor's applicators. The purpose of this work is to validate the outputs provided by the vendor experimentally. METHODS: Using a Flexitron Ir-192 HDR unit, three experimental methods were employed to determine dose with the 30 mm diameter Valencia applicator: first a gradient method using extrapolation ionization chamber (Far West Technology, EIC-1) measurements in solid water phantom at 3 mm SCD was used...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27906789/radon-and-thoron-in-air-occupational-exposure-study-within-selected-wine-cellars-of-the-western-cape-south-africa-and-associated-annual-effective-doses
#20
MULTICENTER STUDY
R Botha, R T Newman, R Lindsay, P P Maleka
This is the first known study of exposure of Rn (radon) and secondarily Rn (thoron) in-air activity concentrations assessed within nine selected wine cellars in four wine districts of the Western Cape (South Africa) and the associated annual occupational effective doses. E-PERM electret ion chambers (EIC) and RAD-7 α-detectors were used to perform these measurements. The radon in-air levels ranged from 12 ± 4 Bq m to 770 ± 40 Bq m within the nine selected wine cellars. Eight of the nine wine cellars (excluding results from cellar w-6) had a median radon in-air activity concentration of 48 ± 8 Bq m...
January 2017: Health Physics
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