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https://www.readbyqxmd.com/read/29691646/retrospective-validation-of-the-laparoscopic-icg-sln-mapping-in-patients-with-grade-3-endometrial-cancer
#1
Andrea Papadia, Maria Luisa Gasparri, Anda P Radan, Chantal A L Stämpfli, Tilman T Rau, Michael D Mueller
PURPOSE: To evaluate the sensitivity, negative predictive value (NPV) and false-negative (FN) rate of the near infrared (NIR) indocyanine green (ICG) sentinel lymph node (SLN) mapping in patients with poorly differentiated endometrial cancer who have undergone a full pelvic and para-aortic lymphadenectomy after SLN mapping. METHODS: We performed a retrospective analysis of patients with endometrial cancer undergoing a laparoscopic NIR-ICG SLN mapping followed by a systematic pelvic and para-aortic lymphadenectomy...
April 24, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29691619/quantitative-multiparametric-mr-analysis-of-small-renal-lesions-correlation-with-surgical-pathology
#2
Motoyo Yano, Kathryn J Fowler, Santip Srisuwan, Amber Salter, Cary L Siegel
PURPOSE: The purpose of the study is to evaluate the utility of apparent diffusion coefficient (ADC), chemical shift signal intensity index (SII), and contrast enhancement in distinguishing between benign lesions and renal cell carcinoma (RCC) and between subtypes of renal lesions. METHODS: This retrospective study included 98 renal lesions (≤ 3 cm) on MRI with correlative surgical pathology. Scanner field strength, lesion location, and size were recorded. Two readers blinded to surgical pathology independently measured ADC ratio (ADC lesion/ADC non-lesion kidney), SII, and absolute/relative enhancement in the corticomedullary and nephrographic phases of contrast...
April 24, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29691298/enhanced-therapeutic-activity-of-non-internalizing-small-molecule-drug-conjugates-targeting-carbonic-anhydrase-ix-in-combination-with-targeted-interleukin-2
#3
Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Sarah Wulhfard, Dario Neri
PURPOSE: Antibody-drug conjugates and small molecule-drug conjugates have been proposed as alternatives to conventional anti-cancer cytotoxic agents, with the potential to deliver bioactive payloads to the site of disease, helping spare normal tissues. Experimental Design: Here we describe a novel small molecule-drug conjugate, based on a high-affinity ligand specific to carbonic anhydrase IX. The product featured a peptidic linker, suitable for cleavage in the tumor extracellular environment, and monomethyl auristatin E as cytotoxic payload...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29689599/role-of-metastasis-directed-treatment-in-kidney-cancer
#4
REVIEW
Sarah P Psutka, Viraj A Master
Despite the rapid elaboration of multiple, novel systemic agents introduced for metastatic renal cell carcinoma (mRCC) in recent years, a durable complete response remains elusive with systemic therapy alone. Definitive treatment of the metastatic deposit remains the sole potentially curative option and is a cornerstone of mRCC therapy, offering potential for both local control and palliation of tumor-related symptoms. In this review, the evidence supporting the definitive treatment of mRCC is examined and summarized, including the use of surgical metastasectomy, thermal ablation, radiotherapy, and other minimally invasive options...
April 24, 2018: Cancer
https://www.readbyqxmd.com/read/29689304/proteomics-of-liquid-biopsies-depicting-rcc-infiltration-into-the-renal-vein-by-ms-analysis-of-urine-and-plasma
#5
Clizia Chinello, Martina Stella, Isabella Piga, Andrew James Smith, Giorgio Bovo, Marta Varallo, Mariia Ivanova, Vanna Denti, Marco Grasso, Angelica Grasso, Marina Del Puppo, Apostolos Zaravinos, Fulvio Magni
Liquid biopsies, as blood and urine, could offer an invaluable, easily accessible source of biomarkers, and evidences for elucidating the pathological processes. Only few studies integrated the proteomes driven by more than one biofluid. Furthermore, it is not clear which biofluid better mirrors the alterations triggered by disease. Venous infiltrating RCC(Renal Cell Carcinoma) could represent an advantageous model for exploring this aspect. Herein, we investigate how blood and urine "proteomically" reflect the changes occurring during RCC infiltration into renal vein(RV) by label-free nLC-ESI-MS/MS...
April 21, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29689274/the-mechanistic-effects-of-the-dioxonaphthoimidazolium-analog-ym155-in-renal-cell-carcinoma-cell-cycling-and-apoptosis
#6
Mei Yi Sim, Mei Lin Go, John Shyi Peng Yuen
AIM: To investigate the effect of dioxonaphthoimidazolium analog YM155 on cell cycle progression of the clear-cell variant of renal cell carcinoma (ccRCC). MAIN METHODS: Cell cycle analysis was performed using bromodeoxyuridine (BrdU) and PI, apoptosis initiation was monitored using Annexin V and proteins expression was determined using western immunoblotting. KEY FINDINGS: Here, we showed that YM155 activated stress-related molecules (histone H2AX, checkpoint kinases Chk1 and Chk2, p53) that mediate DNA damage checkpoint responses...
April 21, 2018: Life Sciences
https://www.readbyqxmd.com/read/29689242/swi-snf-protein-expression-status-in-fumarate-hydratase-deficient-renal-cell-carcinoma-immunohistochemical-analysis-of-32-tumors-from-28-patients
#7
Abbas Agaimy, Mahul B Amin, Anthony J Gill, Bernt Popp, André Reis, Daniel M Berney, Cristina Magi-Galluzzi, Mathilde Sibony, Steven C Smith, Saul Suster, Kiril Trpkov, Ondřej Hes, Arndt Hartmann
Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare, aggressive RCC type, originally described in the setting of hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome which is defined by germline FH gene inactivation. Inactivation of components of the SWI/SNF chromatin remodelling complex is involved in renal medullary carcinoma (SMARCB1/INI1 loss), clear cell RCC (PBRM1 loss) and in subsets of dedifferentiated RCC of clear cell, chromophobe and papillary types (loss of different SWI/SNF components)...
April 21, 2018: Human Pathology
https://www.readbyqxmd.com/read/29687437/coincidental-bladder-cuff-transitional-cell-carcinoma-in-nephroureterectomy-specimens-risk-factors-prognosis-and-clinical-implementation
#8
Mohamed Mohamed Elawdy, Yasser Osman, Diaa-Eldin Taha, Samer El-Halwagy, Mohsen El-Mekresh
PURPOSE: There is a lack of reporting of the bladder cuff pathology in the literature and ongoing debate regarding the role of bladder cuff excision (BCE) in the prognosis in patients with upper tract urothelial carcinoma (UTUC). We aimed to know the risk factors, the survival, and the clinical course of such pathology. MATERIALS AND METHODS: The study was retrospective, from 1983-2013 on 305 patients who had diagnosed with UTUC. Patients were managed by radical open/ laparoscopic nephroureterectomy with bladder cuff excision...
April 24, 2018: Urology Journal
https://www.readbyqxmd.com/read/29687244/a-population-pharmacokinetic-model-of-cabozantinib-in-healthy-volunteers-and-patients-with-various-cancer-types
#9
Steven Lacy, Bei Yang, Jace Nielsen, Dale Miles, Linh Nguyen, Matt Hutmacher
PURPOSE: An integrated population pharmacokinetic (popPK) model was developed to describe the pharmacokinetics (PK) of tyrosine kinase inhibitor cabozantinib in healthy volunteers (HVs) and patients with various cancer types and to identify any differences in cabozantinib PK across these populations. METHODS: Plasma concentration data used to develop the popPK model were obtained from nine clinical trials (8072 concentrations from 1534 HVs or patients) of cabozantinib in HVs and patients with renal cell carcinoma (RCC), medullary thyroid carcinoma (MTC), glioblastoma multiforme, castration-resistant prostate cancer, or other advanced malignancies...
April 23, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29687160/evaluation-of-relative-dose-intensity-during-the-early-phase-of-first-line-sunitinib-treatment-using-a-2-week-on-1-week-off-regimen-for-metastatic-renal-cell-carcinoma
#10
Kana Iwamoto, Hiroki Ishihara, Toshio Takagi, Tsunenori Kondo, Kazuhiko Yoshida, Junpei Iizuka, Kazunari Tanabe
Sunitinib treatment with a 2-week-on/1-week-off schedule (Schedule 2/1) is a common alternative regimen with high relative dose intensity (RDI) and superior tolerability for patients with metastatic renal cell carcinoma (mRCC). The prognostic impact of RDI is reported only in 4-week-on/2-week-off or mixed regimens. Herein, we evaluated the prognostic impact of RDI during early-phase sunitinib treatment using Schedule 2/1. Seventy-four patients who received first-line sunitinib treatment using Schedule 2/1 were evaluated...
April 23, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29686834/limitations-of-ct-scanning-in-bosniak-staging-of-renal-cystic-carcinoma
#11
A S Wasim, F Mumtaz
The Bosniak Classification is used to quantify the risk of malignancy and need for observation or radical treatment based on the findings of computed tomography (CT). The case described is that of a 65-year-old man with renal cystic disease who was initially given a Bosniak stage IIF classification and was subsequently managed with CT surveillance. CT surveillance showed increased cyst size in the left kidney with cystic changes, however, the Bosniak classification remained the same. It was not until the patient deteriorated further that an MRI was indicated...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29685402/angiomyolipoma-of-the-kidneys-current-perspectives-and-challenges-in-diagnostic-imaging-and-image-guided-therapy
#12
REVIEW
Abdul Razik, Chandan J Das, Sanjay Sharma
Angiomyolipomas (AML) are benign tumors of the kidneys frequently encountered in radiologic practice in large tertiary centers. In comparison to renal cell carcinomas (RCC), AML are seldom treated unless they are large, undergo malignant transformation or develop complications like acute hemorrhage. The common garden triphasic (classic) AML is an easy diagnosis, however, some variants lack macroscopic fat in which case the radiologic differentiation from RCC becomes challenging. Several imaging features, both qualitative and quantitative, have been described in differentiating the 2 entities...
March 20, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29684961/-a-case-of-renal-cell-carcinoma-growing-into-the-renal-pelvis-with-a-fibrin-cap-in-the-ureter-and-bladder
#13
Tatsuro Ishikawa, Koji Izumi, Takuya Kondo, Ken Miyama, Yutaka Osada, Junnichi Ota
We present a case of renal cell carcinoma growing into the renal pelvis with a fibrin cap in the ureter and bladder. A 66-year-old man presented to our hospital with anemia and gross hematuria. Computed tomography showed a large left renal tumor and space-occupying lesions in the left renal pelvis and ureter. Cystoscopy showed a 2 cm-restiform mass protruding from the left ureteral orifice. We performed open left nephroureterectomy, and there was a 3 cm white mass with a smooth surface in the bladder. Pathological examination of the resected mass revealed clear cell carcinoma with urinary collecting system invasion and fibrin cap in the ureter and bladder...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684960/-two-cases-of-metastatic-and-recurrent-non-clear-cell-renal-cell-carcinoma-re-diagnosed-as-renal-mucinous-tubular-and-spindle-cell-carcinoma-during-long-term-follow-up
#14
Masashi Kubota, Toshinari Yamasaki, Yuki Teramoto, Katsuhiro Ito, Hideaki Takada, Toshihiro Magaribuchi, Atsuro Sawada, Shusuke Akamatsu, Hiromitsu Negoro, Ryoichi Saito, Takashi Kobayashi, Naoki Terada, Takahiro Inoue, Tomomi Kamba, Osamu Ogawa
Renal mucinous tubular and spindle cell carcinoma (MTSCC) is a rare, low-grade renal epithelial neoplasm. MTSCC has a lower malignant potential and shows relatively good prognosis, but can be difficult to distinguish from other renal cell carcinoma (RCC) subtypes. Here, we report two cases of metastatic and recurrent renal MTSCC diagnosed after long-term follow-up. Case 1 was a 79-year-old man with a history of macroscopic hematuria in whom a right kidney mass was detected and diagnosed as RCC (cT3bN0M0). After a radical nephrectomy, microscopic findings showed that the tumor consisted of spindle cells arranged in tubular patterns embedded in sarcomatoid tissues ; we diagnosed it as unclassified RCC with sarcomatoid differentiations (pT3aN0M0)...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684959/-a-case-of-chromophobe-renal-cell-carcinoma-associated-with-birt-hogg-dub%C3%A3-syndrome
#15
Yoichiro Tohi, Noriyuki Makita, Issei Suzuki, Ryosuke Suzuki, Arinobu Fukunaga, Masashi Kubota, Takashi Matsuoka, Yoshio Sugino, Koji Inoue, Keiichiro Uehara, Yukihiro Imai, Mutsushi Kawakita
A 61-year-old man with a left renal mass, which was detected by ultrasound during a routine health examination, was referred to our department. The patient had a surgical history of two pneumothorax operations, and the patient's brother also had a history of pneumothorax surgery. A case of Birt-Hogg-Dubé (BHD) syndrome was suspected based on patient history. The pathological diagnosis of the resected tumor, which used robot-assisted laparoscopic partial nephrectomy, was determined to be chromophobe renal cell carcinoma (grade 2, pT1a)...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684950/-metastases-of-urothelial-carcinoma-with-trophoblastic-differentiation-that-responded-to-combination-chemotherapy-with-gemcitabine-and-oxaliplatin-a-case-report
#16
Masahiro Uchida, Koji Kawai, Masahiro Kurobe, Atsushi Ikeda, Shuya Kandori, Tsuyoshi Endo, Tomoaki Miyagawa, Takahiro Kojima, Masakazu Tsutsumi, Hiroyuki Nishiyama
A 70-year-old man was admitted with complaint of gross hematuria. Cystoscopy and computed tomography (CT) revealed a 2.5 cm nodular tumor in the urinary bladder. Pathological diagnosis after the transurethral resection of bladder tumor (TURBT) was invasive urothelial cancer with trophoblastic differentiation of pT1. The tumor was positively stained with human chorionic gonadotropin (HCG). The serum HCG level was 12.8 IU/l in the fourth week after TURBT, and it increased to 35.7 IU/l in the 20th week after TURBT...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684948/-successful-treatment-of-peritoneal-dissemination-recurrence-with-axitinib-in-papillary-renal-cell-carcinoma-a-case-report
#17
Junichi Mori, Yuki Nakayama, Tsuyoshi Hiragino, Hideyasu Matsuyama
We report a case of successful treatment of recurrence of peritoneal dissemination with axitinib. A 55-year-old man presented at our hospital with the chief complaint of remarkable abdominal fullness 18 months after right radical nephrectomy, which had been performed at another hospital for the treatment of renal cell carcinoma. The pathological diagnosis was papillary renal cell carcinoma type 1, pT3aN0M0. A large amount of ascites was detected by computed tomography, and recurrence of peritoneal dissemination was diagnosed (ascites cytology : class V)...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684947/-a-case-of-solitary-metastasis-of-renal-cell-carcinoma-to-the-thyroid-gland
#18
Yuki Yokoi, Kengo Yasuda, Hideyuki Terao, Shinpei Sugiura, Kazuo Kitami, Yuzo Minegishi, Shunichi Gondo
A case of solitary metastasis of renal cell carcinoma to the thyroid gland is presented. The patient was a 82-year-old man found to have an abnormal mass in his neck. He had a past history of renal clear cell carcinoma of the left kidney (pT1aN0M0, G1>2, alveolar type, clear cell subtype), which had been resected 12 years previously. Ultrasonography revealed a tumor mass in the right hemithyroid gland. This time fine needle biopsy of the thyroid tumor suggested metastatic thyroid carcinoma. Right hemithyroidectomy was performed last year...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684209/drug-review-pazopanib
#19
Shingo Miyamoto, Shigenori Kakutani, Yujiro Sato, Akira Hanashi, Yoshitaka Kinoshita, Akira Ishikawa
Pazopanib (Votrient®) is an oral small-molecule multi-kinase inhibitor that primarily inhibits vascular endothelial growth factor receptor-1, -2 and -3, platelet endothelial growth factor receptor-α, and -β, and the stem-cell factor receptor c-kit. In preliminary experiments using angiogenesis models with mice and rabbits, pazopanib inhibited angiogenesis caused by combined vascular endothelial growth factor and basic fibroblast growth factor. Although pazopanib was developed as a therapeutic agent against various tumors, it is currently approved in many countries for advanced soft-tissue sarcoma and renal cell carcinoma...
April 19, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29682721/spontaneous-rupture-of-renal-cell-carcinoma-in-pregnancy-surgical-management-with-fetal-preservation-a-case-report
#20
Abbas Hassanpour, Faisal Ahmed, Babak Shirazi Yeganeh, Bahia Namavar Jahromi, Alireza Makarem
Spontaneous Retroperitoneal hemorrhage in pregnancy is a rare condition. Renal angiomyolipoma (RA) is the most common cause of this hemorrhage. To the best of our knowledge, this is the first reported case of Wunderlich syndrome (WS) due to renal cell carcinoma (RCC) diagnosed in the second trimester of pregnancy.
April 23, 2018: Urology Journal
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