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https://www.readbyqxmd.com/read/29916898/a-case-of-complete-response-to-nivolumab-after-long-term-progression-free-survival-with-tyrosine-kinase-inhibitor
#1
Veronica Mollica, Vincenzo Di Nunno, Beniamino Corcioni, Michelangelo Fiorentino, Elisabetta Nobili, Riccardo Schiavina, Rita Golfieri, Eugenio Brunocilla, Andrea Ardizzoni, Francesco Massari
Nivolumab is an effective and tolerable treatment for metastatic renal cell carcinoma, showing longer median overall survival than everolimus and achieving a good percentage of objective response, stable disease, and prolonged responses. However, very few cases have been reported in the literature of a complete response to nivolumab in the metastatic pretreated setting. Here, we report a case of complete response to nivolumab in II line following sunitinib in a metastatic clear cell renal cell carcinoma with favorable risk according to the IMDC criteria...
June 18, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29915634/renal-cell-carcinoma-presenting-as-an-ampullary-mass-a-case-report-and-review-of-literature
#2
Syed Hasan, Zubair Khan, Mohammad Saud Khan, Umar Darr, Toseef Javaid, Raheel Ahmed, Ali Nawras
We present a case of a 60-year-old female patient who has significant medical history of renal cell carcinoma diagnosed 2 years back and had undergone right nephrectomy and chemotherapy. She presented to the hospital with complaints of abdominal pain and jaundice of 2 weeks duration and was found to have periampullary mass lesion causing compression of distal common bile duct on imaging with computed tomography of abdomen. Endoscopic retrograde cholangiography and endoscopic ultrasound showed ampullary mass lesion causing biliary obstruction along with abdominal lymphadenopathy...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29914269/surgical-approach-does-not-impact-margin-status-following-partial-nephrectomy-for-large-renal-masses
#3
Abimbola Ayangbesan, David M Golombos, Ron Golan, Padraic O'Malley, Patrick Lewicki, Xian Wu, Douglas Scherr
PURPOSE: While surgical approach has recently been associated with positive surgical margin (PSM) following partial nephrectomy (PN) for small (<4 cm) renal masses, its impact on margin status for large (>4 cm) masses is unclear. We sought to evaluate the relationship between margin and surgical approach in patients undergoing PN for large renal masses. MATERIALS AND METHODS: Using the National Cancer Database (NCDB), we identified patients undergoing PN for pathological T1b and T2a renal cell carcinoma (RCC) diagnosed from 2010 to 2013...
June 19, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29914010/superoxide-dismutase-2-expression-can-predict-prognosis-of-renal-cell-carcinoma-patients
#4
Tetsuya Yoshida, Susumu Kageyama, Takahiro Isono, Takeshi Yuasa, Ryoji Kushima, Akihiro Kawauchi, Tokuhiro Chano
BACKGROUND AND OBJECTIVE: Renal cell carcinoma (RCC) is the urological malignancy with the highest mortality rate and is increasing in incidence. The prognostic and predictive biomarkers are highly desired. This study aims to investigate the significance of superoxide dismutase 2 (SOD2) as a clinical biomarker in patients with renal cell carcinomas. METHODS: A cohort of 97 patients with RCC was analyzed retrospectively using various clinical parameters and SOD2 expression by immunohistochemistry...
June 6, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29912766/clinical-utility-of-fluorescence-in-situ-hybridization-fish-for-deletion-of-chromosome-3p-in-the-work-up-of-renal-masses
#5
Carmen M Perrino, Jason A Orien, Jason G Tretter, Weiqiang Zhao, Debra L Zynger
Chromosome 3p deletion is a well-established genetic aberration in clear cell renal cell carcinoma (RCC). We aimed to evaluate the clinical utility of 3p fluorescence in situ hybridization (FISH) on formalin-fixed paraffin-embedded tissue in surgical pathology specimens. 3p:3q <0.8 was established as the cut-off for 3p loss. The 2015 Medicare allowable billing rates were used to estimate the cost. Over 2.5 years (2013 to 2015), 3p FISH was performed on 18 cases per year. Among tested cases, 70% (30/43) were nephrectomies and 30% (14/43) metastases...
June 15, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29912582/biomarkers-of-aggressiveness-in-genitourinary-tumors-with-emphasis-on-kidney-bladder-and-prostate-cancer
#6
Alessia Cimadamore, Silvia Gasparrini, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Nicola Battelli, Francesco Massari, Francesca Giunchi, Michelangelo Fiorentino, Marina Scarpelli, Rodolfo Montironi
Over the last decade, the improvement in molecular techniques and the acquisition of genomic information has transformed and increased the quality of patient care and our knowledge of diseases. Areas covered: Protein expression levels in immunohistochemistry and molecular biomarkers are reported for their ability to predict recurrence, progression, development of metastases, or patient survival. In particular, for renal cell carcinoma, we take into consideration the biomarkers applicable to immunohistochemistry and with molecular and genetic analyses...
June 18, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29912290/accounting-for-differential-variability-in-detecting-differentially-methylated-regions
#7
Ya Wang, Andrew E Teschendorff, Martin Widschwendter, Shuang Wang
DNA methylation plays an essential role in cancer. Differential variability (DV) in cancer was recently observed that contributes to cancer heterogeneity and has been shown to be crucial in detecting epigenetic field defects, DNA methylation alterations happening early in carcinogenesis. As neighboring CpG sites are highly correlated, here, we present a new method to detect differentially methylated regions (DMRs) that uses combined signals from differential methylation and DV between sample groups. We demonstrated in simulation studies the superior performance of the new method than existing methods that use only one type of signals when true DMRs have both...
August 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29911518/biopsychosocial-distress-and-clinical-outcome-in-metastatic-renal-cell-carcinoma
#8
Cristiane Decat Bergerot, Karen Lynn Clark, Kimlin Tam Ashing, Paulo Gustavo Bergerot, Richard Obenchain, Nazli Dizman, JoAnn Hsu, Errol Philip, Matthew Loscalzo, Sumanta Kumar Pal
OBJECTIVE: Limited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship between distress and overall survival. METHOD: A cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen-based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains...
June 18, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29911113/survival-outcomes-for-advanced-kidney-cancer-patients-in-the-era-of-targeted-therapies
#9
Arpit Rao, Charles Wiggins, Richard C Lauer
Background: Advanced renal cell carcinoma (RCC) results in over 14,000 deaths each year in the United States alone. The therapeutic landscape for advanced RCC changed dramatically with the approval of tyrosine kinase inhibitors (TKI) between 2006 and 2012. A large-scale analysis of survival trends has not been performed in the TKI era to determine their impact on outcomes for advanced RCC patients. Methods: The Surveillance, Epidemiology and End-Results (SEER) database was queried for adult patients with advanced RCC diagnosed between 2000 and 2013...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29910688/recalling-cohnheim-s-theory-papillary-renal-cell-tumor-as-a-model-of-tumorigenesis-from-impaired-embryonal-differentiation-to-malignant-tumors-in-adults
#10
Daniel Banyai, Donat P Sarlos, Anetta Nagy, Gyula Kovacs
We have suggested that papillary renal cell tumor (PRCT) of the kidney arises from nephrogenic rest-like lesions. To approve our hypothesis, we worked up 14 kidneys bearing papillary and 14 ones with conventional renal cell carcinoma (CRCC) histologically and found 42 papillary lesions in average per kidney bearing PRCT. PRCTs are characterized by loss of the Y chromosome and trisomy of chromosomes 7 and 17. The MET and HNF1B are localized to chromosome 7q31 and 17q21 and are frequently amplified in PRCT. We have analyzed the expression of the mutant MET in hereditary PRCTs and precursor lesions and found duplication and expression of the mutated allele...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29910061/potential-impact-of-pd-l1-sp-142-immunohistochemical-heterogeneity-in-clear-cell-renal-cell-carcinoma-immunotherapy
#11
José I López, Rafael Pulido, Jesús M Cortés, Javier C Angulo, Charles H Lawrie
Intratumor heterogeneity (ITH) detection remains a challenge in modern oncology because it can have a direct impact on the success of new therapies. Anti-PD-1/PD-L1 immunotherapy is an emerging treatment modality that is showing great promise for clear cell renal cell carcinoma (CCRCC) patients with advanced disease. Patient selection for such therapy relies upon the immunohistochemical detection of PD-1/PD-L1, however the degree of ITH for these markers among tumor cells and/or inflammatory mononuclear infiltrates remains unknown...
June 12, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29909921/myositis-as-an-adverse-event-of-immune-checkpoint-blockade-for-cancer-therapy
#12
Mohsin Shah, Jean H Tayar, Noha Abdel-Wahab, Maria E Suarez-Almazor
OBJECTIVES: Immune checkpoint inhibitors (ICIs) can successfully treat cancer, but their use can be hindered by serious immune-related adverse events. We report six patients receiving ICIs who presented with de novo myositis. METHODS: We identified patients with myositis who were receiving ICIs between January 2004 and September 2016 at The University of Texas MD Anderson Cancer Center. RESULTS: Six patients developed de novo myositis. The mean age was 64...
May 18, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29907148/a-case-of-metaplastic-atrophic-gastritis-in-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-ipex-syndrome
#13
Youyou Luo, Jie Chen, Youhong Fang, Jingan Lou, Jindan Yu
BACKGROUND: Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia and carcinoma. It is rare in paediatric cohorts. CASE PRESENTATION: We present the case of a boy with metaplastic atrophic gastritis in whom immune dysregulation, polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome was confirmed by FOXP3 gene mutation...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29905933/the-classification-of-pediatric-and-young-adult-renal-cell-carcinomas-registered-on-the-children-s-oncology-group-cog-protocol-aren03b2-after-focused-genetic-testing
#14
Mariana M Cajaiba, Lisa M Dyer, James I Geller, Lawrence J Jennings, David George, Dawn Kirschmann, Stephen M Rohan, Nicholas G Cost, Geetika Khanna, Elizabeth A Mullen, Jeffrey S Dome, Conrad V Fernandez, Elizabeth J Perlman
BACKGROUND: Renal cell carcinomas (RCCs) are rare in young patients. Knowledge of their pathologic and molecular spectrum remains limited, and no prospective studies have been performed to date in this population. This study analyzes patients diagnosed with RCC who were prospectively enrolled in the AREN03B2 Children's Oncology Group (COG). The objective was to classify these tumors with the aid of focused genetic testing and to characterize their features. METHODS: All tumors registered as RCC by central review were retrospectively re-reviewed and underwent additional ancillary studies...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29905412/myeloid-derived-suppressor-cell-accumulation-in-renal-cell-carcinoma-is-correlated-with-ccl2-il-17-and-il-18-expression-in-blood-and-tumors
#15
Xiaodong Guan, Zhiyu Liu, Jianhua Zhang, Xunbo Jin
BACKGROUND: Myeloid-derived suppressor cells (MDSC) play an important role in tumor-mediated immune evasion. Levels of MDSC in peripheral blood are increased in patients with cancer, correlating with cancer stage and outcome. Studies have confirmed the associations between MDSC and various cytokines in the peripheral blood of murine and human cancer hosts. However, little is known about the association between parenchymal MDSC subsets and cytokines, or the mechanism drawing MDSC into tumor parenchyma...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29904457/atrial-metastasis-of-renal-cell-carcinoma-a-rare-presentation
#16
Shilpi Shah, Poornima Vinod, Mohamed Khayata, Jason L Lane, Vinayak Hegde, Rupesh Raina
Renal cell carcinoma (RCC) is an aggressive and lethal tumor that has a high frequency of metastatic spread to unpredictable sites. One quarter of patients have either distant metastases or significant local-regional disease with atypical symptoms on presentation. We present a 41-year-old patient with symptoms of right heart failure and was found to have metastatic renal cell carcinoma with enhancing tumor from left renal vein up to right atrium.
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29904312/secondary-involvement-of-the-gastrointestinal-tract-by-renal-cell-carcinoma
#17
Daniel S Grosser, He Huang
Secondary involvement of the gastrointestinal (GI) tract by renal cell carcinoma is rare. We undertook a retrospective review of our institution's pathology records from January 2006 to July 2017 and identified eight cases of GI tract involvement by renal cell carcinoma. Sites of involvement included stomach, duodenum, jejunum, ileum, and cecum. Pertinent clinical information was obtained from electronic medical records. The interval from primary resection to identification of GI involvement was often prolonged, averaging 6 years, and mimicked primary GI tract malignancies, with presentations including GI bleeding, abdominal pain, and obstruction...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29904105/an-interdisciplinary-consensus-on-the-management-of-bone-metastases-from-renal-cell-carcinoma
#18
REVIEW
Viktor Grünwald, Berit Eberhardt, Axel Bex, Anne Flörcken, Thomas Gauler, Thorsten Derlin, Martin Panzica, Hans Roland Dürr, Knut Achim Grötz, Rachel H Giles, Christian von Falck, Anno Graser, Alexander Muacevic, Michael Staehler
Bone is a major site of haematogenous tumour cell spread in renal cell carcinoma (RCC), and most patients with RCC will develop painful and functionally disabling bone metastases at advanced disease stages. The prognosis of these patients is generally poor and the treatment is, therefore, aimed at palliation. However, RCC-associated bone metastases can be curable in select patients. Current data support a multimodal management strategy that includes wide resection of lesions, radiotherapy, systemic therapy, and other local treatment options, which can improve quality of life and survival...
June 14, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29903571/role-of-cxcl12-and-cxcr4-in-the-pathogenesis-of-hematological-malignancies
#19
Amnon Peled, Shiri Klein, Katia Beider, Jan A Burger, Michal Abraham
The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in many type of tumors including lymphoma, leukemia, glioma, and prostate, breast, colorectal, renal, and hepatocellular carcinomas...
September 2018: Cytokine
https://www.readbyqxmd.com/read/29903415/a-multicenter-phase-ii-trial-of-axitinib-in-patients-with-recurrent-or-metastatic-non-clear-cell-renal-cell-carcinoma-who-had-failed-prior-treatment-with-temsirolimus
#20
Inkeun Park, Se Hoon Lee, Jae Lyun Lee
BACKGROUND: The optimal treatment option for non-clear-cell renal cell carcinoma (nccRCC) is not established. We conducted a multicenter phase II trial of axitinib for patients with advanced nccRCC who had failed prior treatment with temsirolimus. PATIENTS AND METHODS: Patients with histologically confirmed metastatic or recurrent nccRCC received 5 mg axitinib twice daily. Prior use of vascular endothelial growth factor pathway inhibitors was not allowed. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were objective response rate (ORR), disease control rate, overall survival, and safety...
May 23, 2018: Clinical Genitourinary Cancer
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