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https://www.readbyqxmd.com/read/28654902/cryptotanshinone-inhibits-proliferation-yet-induces-apoptosis-by-suppressing-stat3-signals-in-renal-cell-carcinoma
#1
Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zheng
It has been established that signal transducer and activator of transcription 3 serves as an oncoprotein in various human cancers; targeting it is therefore a reasonable approach for emerging cancer therapies. Cryptotanshinone, a natural compound extracted from the root of Salvia miltiorrhiza Bunge, has been identified as a potential STAT3 inhibitor. However, its functional role in renal cell carcinomas remains largely unknown. Therefore, we investigated the mode of action for cryptotanshinone. We found that cryptotanshinone substantially suppressed cancer cell growth while it promoted cell apoptosis by inhibiting the phosphorylation of STAT3 at Tyr705 and its blocking nuclear translocation...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654897/secreted-mir-210-3p-as-non-invasive-biomarker-in-clear-cell-renal-cell-carcinoma
#2
Vincenzo Petrozza, Antonio Luigi Pastore, Giovanni Palleschi, Claudia Tito, Natale Porta, Serena Ricci, Chiara Marigliano, Manuela Costantini, Giuseppe Simone, Angelina Di Carlo, Michele Gallucci, Antonio Carbone, Francesco Fazi
The most common subtype of renal cell carcinoma (RCC) is clear cell RCC (ccRCC). It accounts for 70-80% of all renal malignancies representing the third most common urological cancer after prostate and bladder cancer. The identification of non-invasive biomarkers for the diagnosis and responsiveness to therapy of ccRCC may represent a relevant step-forward in ccRCC management. The aim of this study is to evaluate whether specific miRNAs deregulated in ccRCC tissues present altered levels also in urine specimens...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654795/low-expression-of-long-noncoding-rna-casc2-indicates-a-poor-prognosis-and-promotes-tumorigenesis-in-thyroid-carcinoma
#3
Xiangqing Xiong, Hua Zhu, Xiangjian Chen
Recently, long noncoding RNAs (lncRNAs) have been shown to be linked to regulate different biological processes, such as cell growth, differentiation and tumorigenesis. LncRNAs have been identified to be promising clinical biomarkers in various tumors. Long noncoding RNAs cancer susceptibility candidate 2 (CASC2) has recently been demonstrated to be correlated to tumorigenesis in renal cell carcinoma, lung carcinoma, glioma, and gastric carcinoma. Nevertheless, the research on the biological function and clinical significance of CASC2 in thyroid carcinoma are still unclear...
June 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28654655/the-prognostic-value-of-bap1-pbrm1-ps6-pten-tgase2-pd-l1-ca9-psma-and-ki-67-tissue-markers-in-localized-renal-cell-carcinoma-a-retrospective-study-of-tissue-microarrays-using-immunohistochemistry
#4
Sung Han Kim, Weon Seo Park, Eun Young Park, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
OBJECTIVE: To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma (RCC). METHODS: Patients who underwent a nephrectomy during 1992-2015 and had a primary specimen of their kidney tumor were included. The nine tissue biomarkers were immunohistochemically stained on tissue microarrays of RCC, and the semi-quantitative H-score, including intensity score, was used to grade the sample...
2017: PloS One
https://www.readbyqxmd.com/read/28653574/combination-of-sorafenib-and-cytokine-induced-killer-cells-in-metastatic-renal-cell-carcinoma-a-potential-regimen
#5
Yonghao Yang, Hongwei Lin, Lingdi Zhao, Yongping Song, Quanli Gao
Metastatic renal cell carcinoma (MRCC) exhibits primary resistance to both chemotherapy and radiotherapy. As an immunogenic cancer, MRCC is relatively sensitive to immunotherapy such as that with cytokines, immune checkpoint inhibitors and adoptive T-cell therapy. In addition, many targeted agents developed over the past decade exhibit greater efficacy than cytokines and have become the standard first-line therapy for MRCC. Several preclinical studies have shown that the targeted agent sorafenib possesses an immunomodulation function and may be suitable for combination with immunotherapy...
June 2017: Immunotherapy
https://www.readbyqxmd.com/read/28652876/positive-surgical-margins-during-partial-nephrectomy-for-renal-cell-carcinoma-results-from-canadian-kidney-cancer-information-system-ckcis-collaborative
#6
Rahul K Bansal, Simon Tanguay, Antonio Finelli, Ricardo Rendon, Ronald B Moore, Rodney H Breau, Louis Lacombe, Peter C Black, Jun Kawakami, Darrel Drachenberg, Stephen Pautler, Olli Saarela, Zhihui Liu, Michael A S Jewett, Anil Kapoor
INTRODUCTION: We sought to determine the incidence, risk factors, and prognosis for patients with positive surgical margin (PSM) during partial nephrectomy (PN) for renal cell carcinoma (RCC). METHODS: From the Canadian Kidney Cancer information system (CKCis) database, a historical cohort of PN patients with PSM were identified and compared to negative surgical margin (NSM). Risk factors for PSM were examined through multivariable logistic regression. Kaplan-Meier curves were used to compare progression-free survival...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28652767/prognostic-value-of-high-imp3-expression-in-solid-tumors-a-meta-analysis
#7
Luyao Chen, Yongpeng Xie, Xintao Li, Liangyou Gu, Yu Gao, Lu Tang, Jianwen Chen, Xu Zhang
BACKGROUND: Accumulated studies have investigated the prognostic role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in various cancers, but inconsistent and controversial results were obtained. Therefore, we performed a systematic review and meta-analysis to investigate the potential value of IMP3 in the prognostic prediction of human solid tumors. MATERIALS AND METHODS: A systematic literature search in the electronic databases PubMed, Embase, Web of Science, and Cochrane library (updated to April 2016) was conducted to identify eligible studies...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28652455/rapid-progressive-disease-after-nivolumab-therapy-in-three-patients-with-metastatic-renal-cell-carcinoma
#8
Yuki Kobari, Tsunenori Kondo, Toshio Takagi, Kenji Omae, Hayakazu Nakazawa, Kazunari Tanabe
BACKGROUND/AIM: Rapid progressive disease (RPD), accelerated tumour growth immediate after the initiation of immune checkpoint inhibitor therapy, has been reported in melanoma and lung cancer. Herein, we describe 3 cases of RPD during the initial phase of nivolumab treatment for metastatic renal cell carcinoma. PATIENTS AND METHODS: The first and second patients received nivolumab in the fourth-line setting. The third patient received nivolumab therapy as third-line treatment...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652430/the-contribution-of-mmp-7-promoter-polymorphisms-in-renal-cell-carcinoma
#9
Cheng-Hsi Liao, Wen-Shin Chang, Pei-Shin Hu, Hsi-Chin Wu, Shih-Wei Hsu, Yen-Fang Liu, Shih-Ping Liu, Huey-Shan Hung, DA-Tian Bau, Chia-Wen Tsai
BACKGROUND/AIM: Mounting evidence has suggested that polymorphisms in the promoters of matrix metalloproteinase (MMP) genes are associated with the risk of many types of cancer, but no study has ever explored these polymorphisms as biomarkers for renal cell cancer (RCC). Recently, it was suggested that serum MMP-7 levels have both diagnostic and prognostic potential for RCC. In this study, we focused on the contribution of two functional polymorphisms in the promoter region of MMP-7 (A-181G and C-153T) to RCC...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652159/skin-to-tumor-distance-predicts-treatment-failure-of-t1a-renal-cell-carcinoma-following-percutaneous-cryoablation
#10
Simone L Vernez, Zhamshid Okhunov, Kamaljot Kaler, Ramy F Youssef, Rahul Dutta, Arkadiy Palvanov, Paras Shah, Kathryn Osann, David N Siegel, Igor Lobko, Louis Kavoussi, Ralph V Clayman, Jaime Landman
OBJECTIVE: To determine the impact of skin-to-tumor (STT) distance on the risk for treatment failure following PCA. METHODS: We retrospectively reviewed patients who underwent PCA with documented T1a recurrent renal cell carcinoma (RCC) at two academic centers between 2005 and 2015. Patient demographics, tumor characteristics, perioperative and post-operative course variables were collected. Additionally, we measured the STT by averaging the distance from the skin to the center of the tumor at 0, 45 and 90 degrees on preoperative computed tomography imaging...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28651491/manifestation-of-osteoblastic-phenotypes-in-the-sarcomatous-component-of-epithelial-carcinoma-and-sarcomatoid-carcinoma
#11
Yasutoshi Takashima, Teppei Murakami, Takao Inoue, Man Hagiyama, Azusa Yoneshige, Syunji Nishimura, Masao Akagi, Akihiko Ito
Epithelial carcinomas occasionally have sarcomatous components that consist primarily of spindle and cuboidal cells, which often resemble osteoblasts. Sarcomatoid carcinomas consist of similar cells. Recent studies have characterized these phenomena as a manifestation of epithelial-mesenchymal transition in carcinoma cells, but the mesenchymal phenotypes that manifest in sarcomatous cells of epithelial carcinomas are not well understood. Here, we examined the expression profiles of four osteoblastic differentiation biomarkers in the sarcomatous components of multiple carcinoma types, including five renal clear cell, four breast invasive ductal, two esophageal, one maxillary squamous cell, three larynx, three lung, one liver, and one skin sarcomatoid carcinoma...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28650865/effect-of-obesity-on-bladder-cancer-and-renal-cell-carcinoma-incidence-and-survival
#12
Philipp Gild, Behfar Ehdaie, Luis A Kluth
PURPOSE OF REVIEW: The prevalence of obesity has risen dramatically in the general population and among cancer survivors in the last three decades. In this review, we highlight the impact of obesity on carcinogenesis and survival with a focus on bladder cancer and renal cell carcinoma (RCC). RECENT FINDINGS: Obesity presents an established risk factor for an up to 1.8-fold relative risk of RCC. Data with regard to bladder cancer are less abundant but support this association as well...
June 24, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28650600/clear-cell-neuroendocrine-tumor-of-the-pancreas-in-von-hippel-lindau-disease-a-case-report-and-literature-review
#13
(no author information available yet)
Clear cell neuroendocrine tumor (NET) of the pancreas is found in von Hippel-Lindau (VHL) disease, multiple endocrine neoplasia type I (MEN I), and sporadic form. Clear cell NETs are often misdiagnosed as metastatic renal cell carcinoma. A 47-year-old woman with VHL was found to have a mass in the pancreatic tail and two masses in the right kidney with two cysts. A distal pancreatectomy and right radical nephrectomy were performed. The pancreatic lesion was a well-circumscribed, golden-yellow solid mass, which was lobulated by septal fibrosis...
May 26, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28650583/von-hippel-lindau-development-in-children-and-adolescents
#14
Karoline Launbjerg, Iben Bache, Michael Galanakis, Marie Luise Bisgaard, Marie Louise M Binderup
The autosomal dominant von Hippel-Lindau disease (vHL) is associated with a lifelong risk of tumor development, especially retinal and CNS hemangioblastomas, pheochromocytoma, and renal cell carcinoma. Knowledge of paediatric vHL development is limited, and current surveillance guidelines are based on expert opinions. We aimed to describe the course of vHL development in children and adolescents, focusing on age at first manifestation, manifestation frequencies, and types. The prevalence of vHL diagnosis as well as manifestations in childhood were evaluated based on 99 patients, who had started surveillance before 18 years: 37 Danish patients from the national vHL research database and 62 international patients reported in 15 articles...
June 26, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28650002/cabozantinib-use-in-renal-cell-carcinoma
#15
A J Neuwelt, S Mathur, A T Johnson, E R Kessler, D W Bowles
In the last several years, many new drugs have been approved to treat metastatic renal cell carcinoma (RCC). Cabozantinib is a novel multikinase inhibitor with activity against vascular endothelial growth factor receptor (VEGFR), proto-oncogene tyrosine-protein kinase receptor Ret and other kinases that recently joined this impressive list of approved agents. Cabozantinib is an active agent in the preclinical and clinical setting, having recently demonstrated superiority over everolimus in a blinded, randomized phase III study of patients with progressive RCC after at least one prior line of antiangiogenic therapy...
May 2017: Drugs of Today
https://www.readbyqxmd.com/read/28648905/antibodies-against-immune-checkpoint-molecules-restore-functions-of-tumor-infiltrating-t-cells-in-hepatocellular-carcinomas
#16
Guoying Zhou, Dave Sprengers, Patrick P C Boor, Michail Doukas, Hannah Schutz, Shanta Mancham, Alexander Pedroza-Gonzalez, Wojciech G Polak, Jeroen de Jonge, Marcia Gaspersz, Haidong Dong, Kris Thielemans, Qiuwei Pan, Jan N M IJzermans, Marco J Bruno, Jaap Kwekkeboom
BACKGROUND & AIMS: Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), downregulates the T-cell-mediated immune response (called immune checkpoints). Antibodies that block these receptors increase anti-tumor immunity in patients with melanoma, non-small cell lung cancer, and renal cell cancer. Tumor-infiltrating CD4(+) and CD8(+) T cells in patients with hepatocellular carcinoma (HCC) have been found to be functionally compromised...
June 22, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28648756/clinicopathologic-features-and-prognosis-of-sporadic-bilateral-renal-cell-carcinoma-a-series-of-148-cases
#17
Nienie Qi, Teng Li, Xianghui Ning, Xiang Peng, Lin Cai, Kan Gong
INTRODUCTION: The purpose of this study was to investigate the clinicopathologic features, treatment, and prognosis of sporadic bilateral renal cell carcinoma (RCC). PATIENTS AND METHODS: A total of 148 patients with sporadic bilateral RCC treated in our center from June 1986 to December 2015 were included in this retrospective study. Their clinicopathologic features and treatments were evaluated. The survival and prognostic factors were assessed based on data from follow-up...
March 28, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28648469/long-term-clinical-outcomes-following-radiofrequency-and-microwave-ablation-of-renal-cell-carcinoma-at-a-single-va-medical-center
#18
Salim E Abboud, Tanay Patel, Stephanie Soriano, Joseph Giesler, Nannette Alvarado, Preet Kang
PURPOSE: Microwave ablation (MWA) is a relatively newer treatment modality for treatment of renal cell carcinoma (RCC), and only a few small studies have examined the short- and long-term outcomes for MWA applied to renal tumors. The purpose of this retrospective review is to assess the initial experience including technical short- and long-term success rates of using radiofrequency ablation (RFA) and MWA for RCC at a single Veterans Affairs (VA) medical center. MATERIALS AND METHODS: Tumor characteristics were recorded using the R...
May 17, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28648123/value-of-intravoxel-incoherent-motion-in-assessment-of-pathological-grade-of-clear-cell-renal-cell-carcinoma
#19
Qingqiang Zhu, Jing Ye, Wenrong Zhu, Jingtao Wu, Wenxin Chen
Background Intravoxel incoherent motion (IVIM) can provide a unique view of tissue perfusion without the use of exogenous contrast agents. Purpose To investigate the value of IVIM in assessing grades of clear cell renal cell carcinoma (CRCC). Material and Methods A total of 107 patients with pathologically proven CRCC were included, 26 with grade I, 27 with grade II, 25 with grade III, and 29 with grade IV. These tumors were divided into low (I + II) and high grades (III + IV). Nine b values (0, 30, 50, 80, 150, 300, 500, 800, and 1500 s/mm(2)) were used in diffusion-weighted imaging (DWI)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28647866/coffee-consumption-and-risk-of-renal-cell-carcinoma
#20
Samuel O Antwi, Jeanette E Eckel-Passow, Nancy D Diehl, Daniel J Serie, Kaitlynn M Custer, Michelle L Arnold, Kevin J Wu, John C Cheville, David D Thiel, Bradley C Leibovich, Alexander S Parker
BACKGROUND: Studies have suggested an inverse association between coffee consumption and risk of renal cell carcinoma (RCC); however, data regarding decaffeinated coffee are limited. METHODS: We conducted a case-control study of 669 incident RCC cases and 1,001 frequency-matched controls. Participants completed identical risk factor questionnaires that solicited information about usual coffee consumption habits. The study participants were categorized as non-coffee, caffeinated coffee, decaffeinated coffee, or both caffeinated and decaffeinated coffee drinkers...
June 24, 2017: Cancer Causes & Control: CCC
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