Tara-Yesomi Wenegieme, Dalia Elased, Kelia E McMichael, Jananie Rockwood, Khanzada Hasrat, Adaku C Ume, Andrea G Marshall, Kit Neikirk, Annet Kirabo, Khalid M Elased, Antentor Hinton, Clintoria R Williams
Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of diseases...
April 5, 2024: American Journal of Physiology. Heart and Circulatory Physiology