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Hyperadrenocorticism

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https://www.readbyqxmd.com/read/28266313/development-of-a-plasminogen-activator-inhibitor-pai-1-assay-and-comparison-of-plasma-pai-1-activity-in-hyperlipidemic-dyslipidemic-dogs-with-either-hyperadrenocorticism-or-diabetes-mellitus-and-healthy-dogs
#1
Cheryl J Wong, Michael Koch, Erica L Behling-Kelly
Thrombosis is a serious complication of many canine diseases and may be related to decreased fibrinolytic potential. Plasminogen activator inhibitor-1 (PAI-1) is the key regulator of fibrinolysis with increased levels demonstrated in states of pro-thrombosis and abnormal lipid metabolism. Our objective was to develop and validate a canine PAI-1 activity assay and test whether dogs with hyperadrenocorticism or diabetes mellitus that are hyperlipidemic/dyslipidemic have increased plasma PAI-1 activity. Functionally active PAI-1 in the plasma sample was incubated with recombinant tissue plasminogen activator (tPA), allowing the formation of a 1:1 stoichiometric inactive complex...
November 8, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/28090682/pituitary-macrotumor-causing-narcolepsy-cataplexy-in-a-dachshund
#2
S Schmid, A Hodshon, S Olin, I Pfeiffer, S Hecht
Familial narcolepsy secondary to breed-specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs. In this report, a pituitary mass is described as a unique cause of narcolepsy-cataplexy in a dog. A 6-year-old male neutered Dachshund had presented for acute onset of feeding-induced cataplexy and was found to have a pituitary macrotumor on magnetic resonance imaging (MRI). Cerebral spinal fluid hypocretin-1 levels were normal, indicating that tumor effect on the ventral lateral nucleus of the hypothalamus was not the cause of the dog's narcolepsy-cataplexy...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28064467/clinical-relationship-between-cholestatic-disease-and-pituitary-dependent-hyperadrenocorticism-in-dogs-a-retrospective-case-series
#3
K-H Kim, S-M Han, K-O Jeon, H-T Kim, Q Li, M-O Ryu, W-J Song, S-C Park, H-Y Youn
BACKGROUND: A high prevalence of cholestatic disease, including gallbladder mucocele (GBM), has been reported in dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH). HYPOTHESIS/OBJECTIVES: Differences exist in the clinical features of dogs with PDH and concurrent cholestatic disease, and also is the management of these dogs with trilostane. ANIMALS: Sixty-five client-owned dogs with naturally occurring PDH. METHODS: This was a retrospective, observational case series...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28005997/lack-of-ubiquitin-specific-protease-8-usp8-mutations-in-canine-corticotroph-pituitary-adenomas
#4
Silviu Sbiera, Marianna A Tryfonidou, Isabel Weigand, Guy C M Grinwis, Bart Broeckx, Sabine Herterich, Bruno Allolio, Timo Deutschbein, Martin Fassnacht, Björn P Meij
PURPOSE: Cushing's disease (CD), also known as pituitary-dependent hyperadrenocorticism, is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. Affected humans and dogs have similar clinical manifestations, however, the incidence of the canine disease is thousand-fold higher. This makes the dog an obvious model for studying the pathogenesis of pituitary-dependent hyperadrenocorticism. Despite certain similarities identified at the molecular level, the question still remains whether the two species have a shared oncogenetic background...
2016: PloS One
https://www.readbyqxmd.com/read/27906457/comparison-of-survival-times-for-dogs-with-pituitary-dependent-hyperadrenocorticism-in-a-primary-care-hospital-treated-with-trilostane-versus-untreated
#5
N Nagata, K Kojima, M Yuki
BACKGROUND: Although pituitary-dependent hyperadrenocorticism (PDH) is one of the most common endocrinopathies in dogs, the effects of withholding treatment on survival time in dogs with PDH remain unclear. HYPOTHESIS/OBJECTIVES: The purpose of this study was to clarify the effects of treatment in dogs with PDH by comparing survival times between dogs treated with trilostane and untreated dogs. ANIMALS: Forty-three dogs diagnosed with PDH at a primary-care hospital in Japan between June 2009 and January 2014...
January 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27824928/carbenoxolone-disodium-treatment-for-canine-pituitary-dependent-hyperadrenocorticism
#6
Takahiro Teshima, Hirotaka Matsumoto, Tomoko Okusa, Rion Uchiyama, Hidekazu Koyama
Pituitary-dependent hyperadrenocorticism (PDH) is mainly caused by pituitary corticotroph tumors in dogs. A characteristic feature of corticotroph tumors is their resistance to negative feedback by glucocorticoids. In some animal species, including dogs, the aberrant expression of 11β-hydroxysteroid dehydrogenase (11HSD), a cortisol metabolic enzyme, is observed in corticotroph tumors. We previously reported that carbenoxolone (CBX), an inhibitor of 11HSD, suppressed ACTH secretion from the pituitary gland, and decreased cortisol concentrations in healthy dogs...
2016: PloS One
https://www.readbyqxmd.com/read/27668581/serum-cholecystokinin-concentrations-in-dogs-with-naturally-acquired-pituitary-dependent-hyperadrenocorticism
#7
Sungjun Noh, Hye-Sun Kim, Jinhwa Chang, Ji-Houn Kang, Dongwoo Chang, Mhan-Pyo Yang
OBJECTIVE To determine serum cholecystokinin (CCK) concentrations in dogs with pituitary-dependent hyperadrenocorticism (PDH) and to evaluate associations among CCK concentration, PDH, and gallbladder mucocele (GBM). ANIMALS 14 client-owned dogs with PDH and 14 healthy dogs. PROCEDURES Dogs were separated into 4 groups: healthy dogs without gallbladder sludge (group A; n = 7), healthy dogs with gallbladder sludge (group B; 7), dogs with PDH and gallbladder sludge (group C; 8), and dogs with PDH and GBM (group D; 6)...
October 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27466969/long-term-follow-up-in-dogs-with-idiopathic-eosinophilic-bronchopneumopathy-treated-with-inhaled-steroid-therapy
#8
A M Canonne, G Bolen, D Peeters, F Billen, C Clercx
BACKGROUND: Treatment of canine idiopathic eosinophilic bronchopneumopathy mainly consists of long-term oral corticosteroid therapy. To avoid side effects, inhaled steroid therapy has been increasingly used but long-term clinical response and potential side effects are sparsely described. OBJECTIVES: Description of clinical response and side effects with long-term fluticasone in dogs with eosinophilic bronchopneumopathy. METHODS: Case series of dogs with eosinophilic bronchopneumopathy and treated with fluticasone monotherapy for at least 6 months...
October 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27428777/paraganglioma-pituitary-adenoma-and-osteosarcoma-in-a-dog
#9
Cecilia Robat, Ruth Houseright, Joanne Murphey, Saundra Sample, Marie Pinkerton
An 11-year-old neutered male Alaskan Malamute mixed-breed dog was presented with a complaint of polyuria/polydipsia (PU/PD), weight loss, tachypnea, regurgitation, and a previous history of nontreated osteosarcoma of the right distal radius, diagnosed 21 months prior. On physical examination, an abdominal mass was palpated. The abdominal mass was aspirated and cytologically diagnosed as a neuroendocrine tumor, suspected to be a pheochromocytoma. Laboratory examination revealed a mild anemia and thrombocytopenia, markedly elevated ATP and ALP activities, and moderate hypercalcemia...
September 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27425787/comparison-of-2-doses-for-acth-stimulation-testing-in-dogs-suspected-of-or-treated-for-hyperadrenocorticism
#10
C Aldridge, E N Behrend, R J Kemppainen, T M Lee-Fowler, L G Martin, C R Ward, D Bruyette, J Pannu, P Gaillard, H P Lee
BACKGROUND: Lowering the cosyntropin dose needed for ACTH stimulation would make the test more economical. OBJECTIVES: To compare the cortisol response to 1 and 5 μg/kg cosyntropin IV in dogs being screened for hyperadrenocorticism (HAC) and in dogs receiving trilostane or mitotane for pituitary-dependent HAC. ANIMALS: Healthy dogs (n = 10); client-owned dogs suspected of having HAC (n = 39) or being treated for pituitary-dependent HAC with mitotane (n = 12) or trilostane (n = 15)...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27352988/infectious-crystalline-keratopathy-in-dogs-and-cats-clinical-in-vivo-confocal-microscopic-histopathologic-and-microbiologic-features-of-eight-cases
#11
Eric C Ledbetter, Patrick L McDonough, Kay Kim
OBJECTIVE: To describe clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of canine and feline cases of infectious crystalline keratopathy (ICK). ANIMALS STUDIED: Six dogs and two cats with naturally acquired ICK. PROCEDURES: Medical records of dogs and cats with a clinical diagnosis of ICK were reviewed. Signalment, medical history, clinical findings, and diagnostic evaluations were retrieved, including corneal cytology, histopathology, in vivo confocal microscopy, and microbiology results...
June 29, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27340403/association-of-renal-resistive-index-renal-pulsatility-index-systemic-hypertension-and-albuminuria-with-survival-in-dogs-with-pituitary-dependent-hyperadrenocorticism
#12
Hung-Yin Chen, Yu-Hsin Lien, Hui-Pi Huang
An increased renal resistive index (RI) and albuminuria are markers of target organ damage secondary to systemic hypertension. This study evaluated associations between systemic blood pressure (SBP), renal RI, pulsatility index (PI), and albuminuria in dogs with pituitary-dependent hyperadrenocorticism (PDH). Predictors of overall mortality were investigated. Twenty client-owned dogs with PDH and 20 clinically healthy client-owned dogs as matched controls were included. Incidence rates of systemic hypertension (SBP ≥ 160 mmHg), albuminuria, and increased renal RI (≥ 0...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27297418/repetitive-ultrasonographic-assessment-of-adrenal-size-and-shape-changes-a-clue-for-an-asymptomatic-sex-hormone-secreting-adenoma
#13
Seunghyeon Yoon, Heejin Oui, Ju-Hwan Lee, Kyu-Yeol Son, Kyoung-Oh Cho, Jihye Choi
Diagnosis of an adrenal tumor without typical clinical signs related to hyperadrenocorticism and elevated alkaline phosphatase is challenging. This report describes a sex hormone-secreting adrenal tumor in a 10-year-old castrated male Shih Tzu evaluated through repetitive ultrasonographic examination. An adrenocorticotropic hormone stimulation test revealed elevated concentrations of androstenedione and 17-hydroxyprogesterone but a normal cortisol concentration. A mass was surgically excised and adenoma was diagnosed histopathologically...
March 30, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27279104/epidemiology-of-hyperadrenocorticism-among-210-824-dogs-attending-primary-care-veterinary-practices-in-the-uk-from-2009-to-2014
#14
D G O'Neill, C Scudder, J M Faire, D B Church, P D McGreevy, P C Thomson, D C Brodbelt
OBJECTIVES: To estimate prevalence and risk factors for diagnosis with hyperadrenocorticism in dogs attending primary-care veterinary practices in the UK from 2009 to 2014. METHODS: Cases were identified by searching the de-identified electronic patient records from UK primary-care veterinary practices participating in the VetCompass Programme. RESULTS: The estimated prevalence for hyperadrenocorticism diagnosis in dogs was 0·28% (95% confidence interval: 0·25 to 0·31)...
July 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27228235/long-term-follow-up-of-renal-function-assessing-serum-cystatin-c-in-dogs-with-diabetes-mellitus-or-hyperadrenocorticism
#15
Sofie J J Marynissen, Pascale M Y Smets, Liesbeth F E Ghys, Dominique Paepe, Joris Delanghe, Sara Galac, Evelyne Meyer, Hervé P Lefebvre, Sylvie Daminet
BACKGROUND: Serum cystatin C (sCysC) is used as biomarker for glomerular filtration rate (GFR). The effects of diabetes mellitus (DM) on renal function in dogs are unclear. Some renal variables have been evaluated in dogs with hyperadrenocorticism (HAC), but not sCysC. OBJECTIVES: The purpose of this study was the validation of a particle-enhanced nephelometric immunoassay (PENIA) for measuring canine sCysC, and to assess renal function in dogs with DM or HAC. METHODS: A PENIA was analytically validated for canine sCysC by determining imprecision and linearity...
June 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27200272/anaesthetic-management-of-a-unilateral-adrenalectomy-of-an-adrenocortical-tumour-in-a-dog
#16
I K Wise, S Boveri
Adrenalectomies in dogs are being more commonly performed, however anaesthetic management of such cases can be challenging due to the multiple aetiologies of adrenal tumours and the physiological role of adrenal glands. This case report describes the anaesthetic management of a dog with clinical signs of hyperadrenocorticism that underwent unilateral adrenalectomy via laparotomy and discusses anaesthetic preparedness, protocol selection and management of complications for dogs undergoing adrenalectomy.
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27184258/corrigendum-to-left-ventricular-structural-and-functional-abnormalities-in-dogs-with-hyperadrenocorticism-j-vet-cardiol-17-3-2015-173-181
#17
Hiroshi Takano, Akira Kokubu, Keisuke Sugimoto, Hiroshi Sunahara, Takuma Aoki, Yoko Fujii
No abstract text is available yet for this article.
June 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27101315/a-magnetic-resonance-imaging-based-classification-system-for-indication-of-trans-sphenoidal-hypophysectomy-in-canine-pituitary-dependent-hypercortisolism
#18
A Sato, T Teshima, H Ishino, Y Harada, T Yogo, N Kanno, D Hasegawa, Y Hara
OBJECTIVES: The objectives of this study were to establish a magnetic resonance imaging-based classification system for canine hyperadrenocorticism according to pituitary gland extension, determine indications for trans-sphenoidal hypophysectomy, and clarify the prognosis for each disease grade. METHODS: A 5-point classification system (Grades 1 to 5) was developed based on tumour extension in dorsal and cranio-caudal directions. Cases were then classified as Type A: no arterial circle of Willis or cavernous sinus involvement and Type B: cases in which these blood vessels were involved...
May 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27074582/dislodgement-of-a-right-atrial-thrombus-and-subsequent-pulmonary-thromboembolism-following-tracheal-stent-deployment-in-a-dog
#19
Ayla R Preston, Lauren A Sullivan
OBJECTIVE: To report the management of a dog that required 2 treatments with mechanical ventilation; firstly for severe tracheal collapse and secondly following deployment of a nitinol tracheal stent that immediately preceded a nonoxygen responsive pulmonary thromboembolism (PTE), suspected to have originated from the right atrium. CASE SUMMARY: A 9-year-old female spayed Shetland Sheepdog was presented for management of a gallbladder mucocoele. Pertinent history included iatrogenic hyperadrenocorticism and tracheal collapse...
November 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27008319/gallbladder-sludge-in-dogs-ultrasonographic-and-clinical-findings-in-200-patients
#20
Audrey K Cook, Anisha V Jambhekar, Allison M Dylewski
Echogenic luminal contents are often noted during ultrasonographic examination of the gallbladder (GB) in canine patients, but the significance of biliary sludge is not well understood. GB contents were evaluated during 200 sequential ultrasonographic scans performed at a veterinary school, and sludge was quantified using a 1-5 scale. GB volume was retrospectively estimated from stored images. Medical records were used to determine patient demographics, clinicopathologic findings, and diagnoses/disorders. The majority of dogs (66...
May 2016: Journal of the American Animal Hospital Association
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