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Hyperadrenocorticism

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https://www.readbyqxmd.com/read/29153102/stability-of-compounded-trilostane-suspension-in-cod-liver-oil
#1
Jesse Crosby, Stacy Brown
Trilostane is a synthetic steroid analog used to treat canine hyperadrenocorticism. For small dogs, the dose found in commercially available dosage forms of trilostane is sometimes too high. Compounding trilostane in a liquid diluent provides an option for more precise dosing and adjustments, and can be easier to administer, versus a tablet or capsule. Trilostane suspends well in cod liver oil, which is generally palatable to dogs. The stability of a compounded trilostane suspension in cod liver oil stored at room temperature was investigated for 90 days...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29069262/an-activating-mutation-in-the-crhr1-gene-is-rarely-associated-with-pituitary-dependent-hyperadrenocorticism-in-poodles
#2
Viviani De-Marco, Luciani R Carvalho, Mariana F Guzzo, Paulo S L Oliveira, Larissa G Gomes, Berenice B Mendonca
OBJECTIVES: Pituitary-dependent hyperadrenocorticism is the most common cause of naturally occurring hypercortisolism in dogs. CRHR1 expression in human and dog corticotrophinomas suggested that this gene affects pituitary tumorigenesis. The present study aimed to investigate mutations in the CRHR1 coding region in poodles with pituitary-dependent hyperadrenocorticism. METHODS: Fifty poodles with pituitary-dependent hyperadrenocorticism and 50 healthy poodles were studied...
October 2017: Clinics
https://www.readbyqxmd.com/read/29031329/dogs-with-macroadenomas-have-lower-body-temperature-and-heart-rate-than-dogs-with-microadenomas
#3
Ghita Benchekroun, Loic Desquilbet, Michael E Herrtage, Nick D Jeffery, Dan Rosenberg, Nicolas Granger
Pituitary macroadenomas compress the hypothalamus, which partly regulates heart rate and body temperature. The aim of this study was to investigate whether heart rate and/or body temperature could aid in clinically differentiating dogs with macroadenomas from dogs with microadenomas (i.e. small non-compressive pituitary mass). Two groups of dogs diagnosed with pituitary-dependent hyperadrenocorticism (i.e. Cushing's disease) were included. Heart rate and body temperature were collected on initial presentation before any procedure...
September 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28921665/effects-of-oral-prednisone-administration-on-serum-cystatin-c-in-dogs
#4
J Muñoz, P Soblechero, F J Duque, B Macías-García, P Ruiz, C Zaragoza, R Barrera
BACKGROUND: Oral administration of glucocorticoid alters serum cystatin C (sCysC) concentration in humans. OBJECTIVE: To determine if oral administration of prednisone alters sCysC in dogs without pre-existing renal disease. ANIMALS: Forty six dogs were included: 10 dogs diagnosed with steroid responsive meningitis arteritis (SRMA; group A), 20 dogs diagnosed of pituitary-dependent hyperadrenocorticism (PDH; group B), and 16 healthy control dogs (group C)...
September 18, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28838299/peculiarities-of-feline-hyperadrenocorticism-update-on-diagnosis-and-treatment
#5
Lara A Boland, Vanessa R Barrs
Practical relevance: Hyperadrenocorticism (HAC) is a relatively uncommon endocrinopathy of older cats, with a mean age at diagnosis of 10 years. In addition to pituitary-dependent and adrenal-dependent hypercortisolism, clinical signs of HAC can result from adrenal sex steroid-producing tumours. Clinical challenges: While HAC in cats has many similarities to canine HAC, there are key differences in presentation, diagnosis and response to therapy. Most, but not all, cats with HAC have concurrent diabetes mellitus, which is often insulin resistant...
September 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28781034/evidence-based-advances-in-rodent-medicine
#6
REVIEW
Vladimir Jekl, Karel Hauptman, Zdenek Knotek
The number of exotic companion pet rodents seen in veterinary practices is growing very rapidly. According to the American Veterinary Medical Association's surveys, more than 2,093,000 pet rodents were kept in US households in 2007 and in 2012 it was more than 2,349,000 animals. This article summarizes the most important evidence-based knowledge in exotic pet rodents (diagnostics of the hyperadrenocorticism in guinea pigs, pituitary tumors in rats, urolithiasis in guinea pigs, use of itopride as prokinetics, use of deslorelin acetate in rodents, cause of dental disease, and prevention of mammary gland tumors in rats)...
September 2017: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/28759861/concurrent-hyperadrenocorticism-and-diabetes-mellitus-in-dogs
#7
D D Miceli, O P Pignataro, V A Castillo
Hyperadrenocorticism (HAC) and diabetes mellitus (DM) are two diseases that can occur concurrently in dogs. The objective of this study was to evaluate the coexistence of HAC and DM, and the risk factors involved that could contribute to the development of DM in dogs with HAC. A total of 235 dogs with HAC were studied and, according to their fasting glycemia, they were divided into three groups: <5.6mmol/L, between 5.6 and 10.08mmol/L and >10.08mmol/L. The following parameters were evaluated: age, gender, cause of HAC, body condition, glycemia, total cholesterol, triglycerides, urinary cortisol:creatinin ratio (UCCR) and survival time...
July 25, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28560045/correlation-of-neuter-status-and-expression-of-heritable-disorders
#8
Janelle M Belanger, Thomas P Bellumori, Danika L Bannasch, Thomas R Famula, Anita M Oberbauer
BACKGROUND: Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of orthopedic conditions, cognitive decline, and a predisposition to some neoplasias. This study was designed specifically to identify if a correlation exists between neuter status and inherited conditions in a large aggregate cohort of dogs representing many different breeds...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28447709/-atypical-cushing-s-syndrome-in-a-dog-a-case-report-ein-fallbericht
#9
Stefanie Hoffrogge, Lena Fels, Marion Schmicke, Reinhard Mischke
In a 12-year-old male Labrador Retriever, presented due to other disease symptoms, clinical signs of hyperadrenocorticism (polyuria, polydipsia, abdominal distention, muscle atrophy) were an incidental finding. Abnormal laboratory results and sonographic findings of the adrenal glands, but negative low-dose dexamethasone suppression tests with low basal cortisol concentrations, a negative andrenocorticotropic hormone (ACTH)-stimulation test and exclusion of iatrogenic hyperadrenocorticism, suggested an atypical hyperadrenocorticism (AHAC)...
June 20, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28407319/effect-of-intravenous-or-perivascular-injection-of-synthetic-adrenocorticotropic-hormone-on-stimulation-test-results-in-dogs
#10
C M Johnson, P H Kass, T A Cohen, E C Feldman
BACKGROUND: Standard protocols for adrenocorticotropic hormone (ACTH) stimulation testing (ACTHst) often involve intravenous (IV) injection of corticotropin. ACTH might be unintentionally injected into the perivascular (PV) space. OBJECTIVE: To compare stimulation test results after IV and PV injections of ACTH. ANIMALS: Twenty privately owned dogs were studied: 10 healthy and 10 with trilostane-treated naturally occurring hyperadrenocorticism (HAC)...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28382723/therapy-of-canine-hyperlipidemia-with-bezafibrate
#11
V De Marco, K S M Noronha, T C Casado, E R Nakandakare, J C Florio, E Z Santos, C Gilor
BACKGROUND: Bezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs. OBJECTIVE: To assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations. ANIMALS: Forty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL])...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28371654/extended-low-dose-dexamethasone-suppression-test-for-diagnosis-of-atypical-cushing-s-syndrome-in-dogs
#12
K M Fowler, L A Frank, F Morandi, J C Whittemore
The purpose of this study was to evaluate extension of the low-dose dexamethasone suppression (LDDS) test from 8 h to 12 h to detect possible hypercortisolemia associated with atypical hyperadrenocorticism (AHAC). Twelve client-owned dogs were enrolled in the study: 6 healthy dogs (group 1) and 6 dogs with suspected AHAC (group 2). Baseline EDTA plasma samples were collected for endogenous ACTH determination using an immunoradiometric assay. Serum samples were collected before and at 4, 8, 10, and 12 h post-administration of 0...
March 11, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28266313/development-of-a-plasminogen-activator-inhibitor-pai-1-assay-and-comparison-of-plasma-pai-1-activity-in-hyperlipidemic-dyslipidemic-dogs-with-either-hyperadrenocorticism-or-diabetes-mellitus-and-healthy-dogs
#13
Cheryl J Wong, Michael Koch, Erica L Behling-Kelly
Thrombosis is a serious complication of many canine diseases and may be related to decreased fibrinolytic potential. Plasminogen activator inhibitor-1 (PAI-1) is the key regulator of fibrinolysis with increased levels demonstrated in states of pro-thrombosis and abnormal lipid metabolism. Our objective was to develop and validate a canine PAI-1 activity assay and test whether dogs with hyperadrenocorticism or diabetes mellitus that are hyperlipidemic/dyslipidemic have increased plasma PAI-1 activity. Functionally active PAI-1 in the plasma sample was incubated with recombinant tissue plasminogen activator (tPA), allowing the formation of a 1:1 stoichiometric inactive complex...
April 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28090682/pituitary-macrotumor-causing-narcolepsy-cataplexy-in-a-dachshund
#14
S Schmid, A Hodshon, S Olin, I Pfeiffer, S Hecht
Familial narcolepsy secondary to breed-specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs. In this report, a pituitary mass is described as a unique cause of narcolepsy-cataplexy in a dog. A 6-year-old male neutered Dachshund had presented for acute onset of feeding-induced cataplexy and was found to have a pituitary macrotumor on magnetic resonance imaging (MRI). Cerebral spinal fluid hypocretin-1 levels were normal, indicating that tumor effect on the ventral lateral nucleus of the hypothalamus was not the cause of the dog's narcolepsy-cataplexy...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28064467/clinical-relationship-between-cholestatic-disease-and-pituitary-dependent-hyperadrenocorticism-in-dogs-a-retrospective-case-series
#15
K-H Kim, S-M Han, K-O Jeon, H-T Kim, Q Li, M-O Ryu, W-J Song, S-C Park, H-Y Youn
BACKGROUND: A high prevalence of cholestatic disease, including gallbladder mucocele (GBM), has been reported in dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH). HYPOTHESIS/OBJECTIVES: Differences exist in the clinical features of dogs with PDH and concurrent cholestatic disease, and also is the management of these dogs with trilostane. ANIMALS: Sixty-five client-owned dogs with naturally occurring PDH. METHODS: This was a retrospective, observational case series...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28005997/lack-of-ubiquitin-specific-protease-8-usp8-mutations-in-canine-corticotroph-pituitary-adenomas
#16
Silviu Sbiera, Marianna A Tryfonidou, Isabel Weigand, Guy C M Grinwis, Bart Broeckx, Sabine Herterich, Bruno Allolio, Timo Deutschbein, Martin Fassnacht, Björn P Meij
PURPOSE: Cushing's disease (CD), also known as pituitary-dependent hyperadrenocorticism, is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. Affected humans and dogs have similar clinical manifestations, however, the incidence of the canine disease is thousand-fold higher. This makes the dog an obvious model for studying the pathogenesis of pituitary-dependent hyperadrenocorticism. Despite certain similarities identified at the molecular level, the question still remains whether the two species have a shared oncogenetic background...
2016: PloS One
https://www.readbyqxmd.com/read/27906457/comparison-of-survival-times-for-dogs-with-pituitary-dependent-hyperadrenocorticism-in-a-primary-care-hospital-treated-with-trilostane-versus-untreated
#17
N Nagata, K Kojima, M Yuki
BACKGROUND: Although pituitary-dependent hyperadrenocorticism (PDH) is one of the most common endocrinopathies in dogs, the effects of withholding treatment on survival time in dogs with PDH remain unclear. HYPOTHESIS/OBJECTIVES: The purpose of this study was to clarify the effects of treatment in dogs with PDH by comparing survival times between dogs treated with trilostane and untreated dogs. ANIMALS: Forty-three dogs diagnosed with PDH at a primary-care hospital in Japan between June 2009 and January 2014...
January 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27824928/carbenoxolone-disodium-treatment-for-canine-pituitary-dependent-hyperadrenocorticism
#18
Takahiro Teshima, Hirotaka Matsumoto, Tomoko Okusa, Rion Uchiyama, Hidekazu Koyama
Pituitary-dependent hyperadrenocorticism (PDH) is mainly caused by pituitary corticotroph tumors in dogs. A characteristic feature of corticotroph tumors is their resistance to negative feedback by glucocorticoids. In some animal species, including dogs, the aberrant expression of 11β-hydroxysteroid dehydrogenase (11HSD), a cortisol metabolic enzyme, is observed in corticotroph tumors. We previously reported that carbenoxolone (CBX), an inhibitor of 11HSD, suppressed ACTH secretion from the pituitary gland, and decreased cortisol concentrations in healthy dogs...
2016: PloS One
https://www.readbyqxmd.com/read/27668581/serum-cholecystokinin-concentrations-in-dogs-with-naturally-acquired-pituitary-dependent-hyperadrenocorticism
#19
Sungjun Noh, Hye-Sun Kim, Jinhwa Chang, Ji-Houn Kang, Dongwoo Chang, Mhan-Pyo Yang
OBJECTIVE To determine serum cholecystokinin (CCK) concentrations in dogs with pituitary-dependent hyperadrenocorticism (PDH) and to evaluate associations among CCK concentration, PDH, and gallbladder mucocele (GBM). ANIMALS 14 client-owned dogs with PDH and 14 healthy dogs. PROCEDURES Dogs were separated into 4 groups: healthy dogs without gallbladder sludge (group A; n = 7), healthy dogs with gallbladder sludge (group B; 7), dogs with PDH and gallbladder sludge (group C; 8), and dogs with PDH and GBM (group D; 6)...
October 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27466969/long-term-follow-up-in-dogs-with-idiopathic-eosinophilic-bronchopneumopathy-treated-with-inhaled-steroid-therapy
#20
A M Canonne, G Bolen, D Peeters, F Billen, C Clercx
BACKGROUND: Treatment of canine idiopathic eosinophilic bronchopneumopathy mainly consists of long-term oral corticosteroid therapy. To avoid side effects, inhaled steroid therapy has been increasingly used but long-term clinical response and potential side effects are sparsely described. OBJECTIVES: Description of clinical response and side effects with long-term fluticasone in dogs with eosinophilic bronchopneumopathy. METHODS: Case series of dogs with eosinophilic bronchopneumopathy and treated with fluticasone monotherapy for at least 6 months...
October 2016: Journal of Small Animal Practice
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