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https://www.readbyqxmd.com/read/29456828/theoretical-models-of-inhibitory-activity-for-inhibitors-of-protein-protein-interactions-targeting-menin-mixed-lineage-leukemia-with-small-molecules
#1
Wiktoria Jedwabny, Szymon Kłossowski, Trupta Purohit, Tomasz Cierpicki, Jolanta Grembecka, Edyta Dyguda-Kazimierowicz
Development and binding affinity predictions of inhibitors targeting protein-protein interactions (PPI) still represent a major challenge in drug discovery efforts. This work reports application of a predictive non-empirical model of inhibitory activity for PPI inhibitors, exemplified here for small molecules targeting the menin-mixed lineage leukemia (MLL) interaction. Systematic ab initio analysis of menin-inhibitor complexes was performed, revealing the physical nature of these interactions. Notably, the non-empirical protein-ligand interaction energy comprising electrostatic multipole and approximate dispersion terms ( E (10)El,MTP + E Das ) produced a remarkable correlation with experimentally measured inhibitory activities and enabled accurate activity prediction for new menin-MLL inhibitors...
December 1, 2017: MedChemComm
https://www.readbyqxmd.com/read/29439680/microtiter-miniature-shaken-bioreactor-system-as-a-scale-down-model-for-process-development-of-production-of-therapeutic-alpha-interferon2b-by-recombinant-escherichia-coli
#2
Joo Shun Tan, Sahar Abbasiliasi, Saeid Kadkhodaei, Yew Joon Tam, Teck-Kim Tang, Yee-Ying Lee, Arbakariya B Ariff
BACKGROUND: Demand for high-throughput bioprocessing has dramatically increased especially in the biopharmaceutical industry because the technologies are of vital importance to process optimization and media development. This can be efficiently boosted by using microtiter plate (MTP) cultivation setup embedded into an automated liquid-handling system. The objective of this study was to establish an automated microscale method for upstream and downstream bioprocessing of α-IFN2b production by recombinant Escherichia coli...
January 4, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29430872/semaphorin-3a-receptor-inhibitor-as-a-novel-therapeutic-to-promote-innervation-of-bioengineered-teeth
#3
Sabine Kuchler-Bopp, Dominique Bagnard, Michael Van-der-Heyden, Ysia Idoux-Gillet, Marion Strub, Hervé Gegout, Hervé Lesot, Nadia Benkirane-Jessel, Laetitia Keller
The sensory innervation of the dental pulp is essential for tooth function and protection. It is mediated by axons originating from the trigeminal ganglia and is spatio-temporally regulated. We have previously shown that the innervation of bioengineered teeth can be achieved only under immunosuppressive conditions. The aim of this study was to develop a model to determine the role of Semaphorin 3A (Sema3A) in the innervation of bioengineered teeth. We first analyzed innervation of the dental pulp of mandibular first molars in newborn (postnatal day 0: PN0) mice deficient for Sema3A (Sema3A-/- ), a strong inhibitor of axon growth...
February 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29425660/cranberry-anthocyanin-as-an-herbal-medicine-lowers-plasma-cholesterol-by-increasing-excretion-of-fecal-sterols
#4
Lijun Wang, Hanyue Zhu, Yimin Zhao, Rui Jiao, Lin Lei, Jingnan Chen, Xiaobo Wang, Zhengnan Zhang, Yu Huang, Tiejie Wang, Zhen-Yu Chen
BACKGROUND: Interest in using herbal medicines to treat the hypercholesterolemia is increasing. Cranberry extract could decrease plasma cholesterol, however, the active ingredients and the underlying mechanisms remain largely unknown. HYPOTHESIS: The present study was to test the hypothesis that cranberry anthocyanins (CrA) were at least one of the active ingredients responsible for the cholesterol-lowering activity of cranberry fruits via a mechanism of increasing fecal sterol excretion...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29421070/chimeric-free-vascularized-metatarsophalangeal-joint-with-toe-fillet-flap-a-technique-for-reconstruction-of-the-posttraumatic-metacarpophalangeal-joint-with-concomitant-soft-tissue-defect
#5
REVIEW
Marco Pappalardo, Vincent G Laurence, Yu-Te Lin
For painful, dysfunctional, posttraumatic metacarpophalangeal (MCP) joints, the free vascularized toe joint transfer may represent a good solution. Successful reconstruction is potentially limited, however, by 2 features of the traditional vascularized metatarsophalangeal (MTP) transfer: inadequate arc of flexion and insufficient soft tissue coverage. The solution to both of these dilemmas lies in the manner of utilizing the donor site. Because of its innate hyperextensibility, rotating the MTP 180° volar to dorsal provides the greatest arc of flexion in the reconstructed MCP...
February 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29415557/outcomes-of-resection-and-joint-preserving-arthroplasty-for-forefoot-deformities-for-rheumatoid-arthritis
#6
Masahiro Horita, Keiichiro Nishida, Kenzo Hashizume, Yoshihisa Nasu, Kenta Saiga, Ryuichi Nakahara, Takahiro Machida, Hideki Ohashi, Toshifumi Ozaki
BACKGROUND: We investigated the clinical outcomes of resection and joint-preserving arthroplasty for forefoot deformities in patients with rheumatoid arthritis. METHODS: Sixteen feet of 14 women (average age, 67.1 years; range, 53-82) underwent resection arthroplasty of the metatarsal head (resection group), and 18 feet of 15 women (average age, 61.3 years; range, 40-73) underwent a metatarsophalangeal joint-preserving procedure with shortening oblique metatarsal osteotomies of the lesser toes (joint preservation group)...
February 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29415081/auditory-steady-state-responses-in-primary-and-non-primary-regions-of-the-auditory-cortex-in-neonatal-ventral-hippocampal-lesion-rats
#7
Sibin Li, Lanlan Ma, Yuchen Wang, Xuejiao Wang, Yingzhuo Li, Ling Qin
Auditory steady-state responses (ASSRs) represent the electrophysiological activity of the auditory nervous system in response to a periodic acoustic stimulus. Spectrogram analysis can reveal the frequency and phase information entrained in ASSRs. Clinically, the ASSR is used to detect abnormalities in electroencephalographs obtained from schizophrenia patients, who show reduced power and phase locking of ASSRs. The neonatal ventral hippocampal lesion (NVHL) rat is a widely used model to investigate the neurodevelopmental mechanisms of schizophrenia...
2018: PloS One
https://www.readbyqxmd.com/read/29409268/clinical-and-radiographic-outcomes-of-the-kramer-osteotomy-in-the-treatment-of-bunionette-deformity
#8
David C Lee, Cesar de Cesar Netto, Jackson Rucker Staggers, Rebecca Siegel, Richard Chen, Su-Young Bae, Lew C Schon
BACKGROUND: Bunionette deformity is a painful bony prominence of the 5th metatarsal. We evaluated outcomes of using a Kramer osteotomy to treat this condition. METHODS: Retrospective study of patients treated with a Kramer osteotomy from 2003 and 2016. Outcome measures included Foot Functional Index (FFI) and radiographic measurements. RESULTS: 38 patients (43 feet) with an average follow-up of 55 months. Mean postoperative FFI1 was 19.4...
July 18, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29409247/clinical-and-radiological-outcomes-of-concomitant-endoscopic-gastrocnemius-release-with-scarf-osteotomy
#9
Mun Chun Lai, Jerry Yongqiang Chen, Yeong Huei Ng, Hwei Chi Chong, Kevin Oon Thien Koo, Inderjeet Singh Rikhraj
BACKGROUND: Studies showed patients with hallux valgus also have tight gastrocnemius concomitantly. This study aims to investigate (1) prevalence of tight gastrocnemius in symptomatic hallux valgus (2) clinical and radiological outcomes of concomitant endoscopic gastrocnemius release with scarf osteotomy. METHODS: Between January 2011 to December 2013, 224 patients underwent hallux valgus surgery were evaluated. They were categorized into 2 groups: scarf osteotomy (n=195), scarf and endoscopic gastrocnemius release (combine, n=29)...
March 16, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29394877/differences-in-the-lateral-compartment-joint-space-width-after-anterior-cruciate-ligament-reconstruction-data-from-the-moon-onsite-cohort
#10
Morgan H Jones, Kurt P Spindler, Jack T Andrish, Charles L Cox, Warren R Dunn, Jeff Duryea, Carol L Duong, David C Flanigan, Braden C Fleming, Laura J Huston, Christopher C Kaeding, Matthew J Matava, Nancy A Obuchowski, Heidi L Oksendahl, Richard D Parker, Erica A Scaramuzza, Matthew V Smith, Carl S Winalski, Rick W Wright, Emily K Reinke
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction can effectively return athletes to the playing field, but they are still at risk of developing posttraumatic osteoarthritis (PTOA). No studies have used multivariable analysis to evaluate the predictors of radiographic PTOA in the lateral compartment of the knee at short-term follow-up after ACL reconstruction. PURPOSE: To determine the predictors of radiographic joint space narrowing in the lateral compartment 2 to 3 years after ACL reconstruction in a young, active cohort...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29389485/massage-therapy-in-cortisol-circadian-rhythm-pain-intensity-perceived-stress-index-and-quality-of-life-of-fibromyalgia-syndrome-patients
#11
Felipe Rodrigues de Oliveira, Laura Cristina Visnardi Gonçalves, Filipy Borghi, Larissa Gabriela Rocha Ventura da Silva, Anne Elise Gomes, Gustavo Trevisan, Aglécio Luiz de Souza, Dora Maria Grassi-Kassisse, Danilo Roberto Xavier de Oliveira Crege
We investigate the effects of a massage therapy program (MTP) in cortisol concentration (CC), intensity of pain, quality of life and perceived stress index of fibromyalgia patients. Volunteers (n = 24, aged 26-55 years) were treated with MT, twice a week for three months. They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month. The MT had improvement in quality of life, according to the FIQ results, and promoted reduction in PSQ values after the second (PSQ2-0...
February 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29363945/a-sortase-mediated-high-throughput-screening-platform-for-directed-enzyme-evolution
#12
Zhi Zou, Diana M Mate, Kristin Rübsam, Felix Jakob, Ulrich Schwaneberg
Sortase-catalyzed ligations have emerged as powerful tools for the site-specific ligation of peptides and proteins in material science and biocatalysis. In this work, a directed sortase evolution strategy (SortEvolve) has been developed as a general high-throughput screening (HTS) platform to improve activity of sortase A (Application 1) and to perform directed laccase evolution through a semi-purification process in 96-well microtiter plate (MTP) (Application 2). A semi-purification process in polypropylene MTP (PP-MTP) is achieved through the anchor peptide LCI which acts as adhesion promoter...
January 24, 2018: ACS Combinatorial Science
https://www.readbyqxmd.com/read/29362026/anatomy-and-physiology-of-the-lesser-metatarsophalangeal-joints
#13
REVIEW
Fred T Finney, Ezequiel Cata, James R Holmes, Paul G Talusan
Knowledge and command of anatomy is paramount to effectively treating disorders of the lesser metatarsophalangeal (MTP) joints. The osseous structures consist of the proximal phalanx of the toe and the metatarsal head. The soft tissues on the dorsum of the MTP joint include the joint capsule and the tendons of extensor digitorum longus and extensor digitorum brevis. The proper and accessory collateral ligaments form the medial and lateral walls and contribute to stability in the coronal and sagittal planes...
March 2018: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/29355561/ameliorating-effects-of-d-47-a-newly-developed-compound-on-lipid-metabolism-in-an-animal-model-of-familial-hypercholesterolemia-whhlmi-rabbits
#14
Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, Masashi Shiomi
Improvements induced in lipid metabolism in the liver by D-47, a newly developed compound, were examined herein. WHHLMI rabbits, an animal model of hypercholesterolemia and coronary atherosclerosis, was fed D-47-supplemented chow for 5 weeks at a dose of 30mg/kg. Lipid concentration were assayed using enzymatic methods. Plasma lipoproteins were fractionated with an ultracentrifuge. mRNA expression was analyzed with real-time PCR. Lipidome analyses of lipoproteins were performed using supercritical fluid chromatography mass spectrometry...
January 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29353123/a-locking-compression-plate-versus-the-gold-standard-non-locking-plate-with-lag-screw-for-first-metatarsophalangeal-fusion-a-biomechanical-comparison
#15
Daniel Mandell, John Karbassi, Hanbing Zhou, Brian Burroughs, Philip Aurigemma, Abhay R Patel
INTRODUCTION: The treatment of end-stage first metatarso-phalangeal joint (MTP) arthritis has been arthrodesis. A dorsal non-locking plate with a lag screw has been the standard traditional fixation method. This study compares the biomechanical strength of a locking compression plate (LCP) with and without internal compression versus this known gold standard. METHODS: In group 1, six matched pairs of cadaver great toes were used to compare the standard non-locking dorsal plate and 3...
November 4, 2017: Foot
https://www.readbyqxmd.com/read/29336242/the-influence-of-fatty-acids-on-metoprolol-human-serum-albumin-interaction-in-low-affinity-binding-sites-a-multifactorial-nmr-approach
#16
Agnieszka Szkudlarek, Mariusz Mogielnicki, Danuta Pentak, Anna Ploch, Malgorzata Maciazek-Jurczyk
The aim of the study was to evaluate the mechanism of interaction between metoprolol (MTP) and human serum albumin (HSA) using 1H NMR technique. The analysis of the drug-albumin interaction was based on the observed chemical shifts in combination with correlation times, 2D NOESY 1H NMR spectra and association constants and allowed us to observe the interactions between the aromatic rings of the drug and the amino acids of the protein. The binding of the drug, both in the hydrophobic subdomain and on the surface of the albumin, increases in the presence of fatty acids (FAs)...
January 15, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29315527/modeling-semicontinuous-longitudinal-expenditures-a-practical-guide
#17
Valerie A Smith, Matthew L Maciejewski, Maren K Olsen
OBJECTIVE: To compare different strategies for analyzing longitudinal expenditure data that have a point mass at $0. We provide guidance on parameter interpretation, research questions, and model selection. DATA SOURCES, STUDY DESIGN, AND DATA COLLECTION: One-part models, uncorrelated two-part models, correlated conditional two-part (CTP) models, and correlated marginalized two-part (MTP) models have been proposed for longitudinal expenditures that often exhibit a large proportion of zeros and a distribution of continuous, highly right-skewed positive values...
January 8, 2018: Health Services Research
https://www.readbyqxmd.com/read/29307122/investigation-of-the-antibiotic-resistance-and-biofilm-formation-of-staphylococcus-pseudintermedius-strains-isolated-from-canine-pyoderma
#18
Valentina Stefanetti, Annalisa Bietta, Luisa Pascucci, Maria Luisa Marenzoni, Mauro Coletti, Maria Pia Franciosini, Fabrizio Passamonti, Patrizia Casagrande Proietti
The aim of the present study was to investigate the antibiotic resistance and bio lm formation among a collection of 51 clinical isolates of Staphylococcus pseudintermedius collected from canine pyoderma. All isolates were tested for the susceptibility to a panel of 14 antimicrobial agents by the disk di usion method in Müeller-Hinton agar. Oxacillin resistance was detected by subculture on oxacillin screening agar base. Bio lm formation was investigated by the Microtitre Plate test (MtP) and for some strains by transmission electron microscopy (TEM)...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29306736/early-results-of-roto-glide-joint-arthroplasty-for-treatment-of-hallux-rigidus
#19
Prasad Karpe, Maire-Clare Killen, Amit Chauhan, Raymond Pollock, Rajiv Limaye
BACKGROUND: Traditionally severe hallux rigidus is treated with arthrodesis. Recently arthroplasty has been used in order to retain motion at the metatarsophalangeal joint. AIM: To assess the early to mid-term functional and radiological outcomes in patients undergoing first metatarsophalangeal arthroplasty using the Rotoglide implant. MATERIALS AND METHODS: A prospective review was undertaken to assess functional and radiological outcomes of all patients undergoing an un-cemented three-component first metatarsophalangeal arthroplasty for hallux rigidus...
November 14, 2017: Foot
https://www.readbyqxmd.com/read/29288579/a-robust-protocol-for-directed-aryl-sulfotransferase-evolution-towards-the-carbohydrate-building-block-glcnac
#20
Shohana S Islam, Diana M Mate, Ronny Martínez, Felix Jakob, Ulrich Schwaneberg
Bacterial aryl sulfotransferases (AST) utilize p-nitrophenylsulfate (pNPS) as a phenolic donor to sulfurylate typically a phenolic acceptor. Interest in aryl sulfotransferases is growing because of their broad variety of acceptors and cost-effective sulfuryl-donors. For instance, aryl sulfotransferase A (ASTA) from Desulfitobacterium hafniense was recently reported to sulfurylate D-glucose. In this study, a directed evolution protocol was developed and validated for aryl sulfotransferase B (ASTB). Thereby the well-known pNPS quantification system was advanced to operate efficiently as a continuous screening system in 96-well MTP format with a true coefficient of variation of 14...
December 30, 2017: Biotechnology and Bioengineering
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