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https://www.readbyqxmd.com/read/29661083/measuring-visualized-joint-surface-in-hallux-metatarsophalangeal-arthroscopy
#1
Michael Hull, John T Campbell, Clifford L Jeng, R Frank Henn, Rebecca A Cerrato
BACKGROUND: Arthroscopy has been increasingly used to evaluate small joints in the foot and ankle. In the hallux metatarsophalangeal (MTP) joint, little data exist evaluating the efficacy of arthroscopy to visualize the articular surface. The goal of this cadaveric study was to determine how much articular surface of the MTP joint could be visualized during joint arthroscopy. METHODS: Ten fresh cadaveric foot specimens were evaluated using standard arthroscopy techniques...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29629608/intravenous-pulses-of-methylprednisolone-to-treat-flares-of-immune-mediated-diseases-how-much-how-long
#2
A Danza, I Borgia, J I Narváez, A Baccelli, C Amigo, M Rebella, V Domínguez
Introduction Glucocorticoids are widely used in the treatment of immune-mediated diseases. Despite their widespread use, details on dosing, effectiveness and adverse effects are yet to be determined. Objective To know the current use of methylprednisolone (MTP) in the management of immune-mediated conditions, evaluating the relationship among doses, therapeutic response and adverse effects. Methodology A multicenter retrospective cohort study was designed, including patients who received intravenous pulses of MTP between 1 January 2013 and 12 December 2015 in three different hospitals in Uruguay...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29626799/lipid-reducing-activity-and-toxicity-profiles-of-a-library-of-polyphenol-derivatives
#3
Ralph Urbatzka, Sara Freitas, Andreia Palmeira, Tiago Almeida, João Moreira, Carlos Azevedo, Carlos Afonso, Marta Correia-da-Silva, Emilia Sousa, Madalena Pinto, Vitor Vasconcelos
Obesity is an increasing epidemic worldwide and novel treatments are urgently needed. Polyphenols are natural compounds derived from plants, which are known in particular for their antioxidant properties. However, some polyphenols were described to possess anti-obesity activities in vitro and in vivo. In this study, we aimed to screen a library of 85 polyphenol derivatives for their lipid reducing activity and toxicity. Compounds were analyzed at 5 μM with the zebrafish Nile red fluorescence fat metabolism assay and for general toxicity in vivo...
March 23, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29615848/decoding-imagined-3d-hand-movement-trajectories-from-eeg-evidence-to-support-the-use-of-mu-beta-and-low-gamma-oscillations
#4
Attila Korik, Ronen Sosnik, Nazmul Siddique, Damien Coyle
Objective: To date, motion trajectory prediction (MTP) of a limb from non-invasive electroencephalography (EEG) has relied, primarily, on band-pass filtered samples of EEG potentials i.e., the potential time-series model. Most MTP studies involve decoding 2D and 3D arm movements i.e., executed arm movements. Decoding of observed or imagined 3D movements has been demonstrated with limited success and only reported in a few studies. MTP studies normally use EEG potentials filtered in the low delta (~1 Hz) band for reconstructing the trajectory of an executed or an imagined/observed movement...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29611650/comparison-of-biofilm-formation-by-staphylococcus-aureus-and-staphylococcus-epidermidis-strains-isolated-from-sheep-milk-using-three-diagnostic-methods
#5
M Vasil', Z Farkasova, J Elecko, J Illek, F Zigo
In this study we investigated 24 strains of Staphylococcus aureus and 33 strains of Staphylococcus epidermidis isolated from milk of sheep with clinical mastitis, for their ability to form biofilms. Three methods for the determination of a biofilm were used. When evaluating the growth on Congo Red agar (CRA), 79.2% S. aureus strains and 72.7% S. epidermidis strains were positive for biofilm formation. The quantitative method of biofilm detection on a Microtitre Plate (MTP) revealed positive results for 75.0% of S...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29601818/hepatic-npc1l1-promotes-hyperlipidemia-in-ldl-receptor-deficient-mice
#6
Youlin Wang, Weiqing Tang, Pan Yang, Hyunsu Shin, Qingwang Li
BACKGROUND AND AIMS: Niemann-Pick C1-like1 (NPC1L1), a crucial cholesterol absorption receptor expressed in human intestine and liver. But in mouse it is only expressed in intestine. Previous studies elucidated that expression of human NPC1L1 in mouse liver led to increase of plasma cholesterol due to activation of absorption from bile. However, hepatic NPC1L1 function was not elucidated in LDL receptor deficient mouse (LDLR-/-) in which LDL was a main lipoprotein as in human. METHODS AND RESULTS: L1-Tg/LDLR-/- mouse was created by crossing liver-specific NPC1L1 transgenic mouse (L1-Tg) with LDLR-/-...
March 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29587720/spontaneous-adrenocorticotropic-hormone-acth-normalisation-due-to-tumour-regression-induced-by-metyrapone-in-a-patient-with-ectopic-acth-syndrome-case-report-and-literature-review
#7
Hideyuki Iwayama, Sho Hirase, Yuka Nomura, Tatsuo Ito, Hiroyuki Morita, Kazuo Otake, Akihisa Okumura, Junko Takagi
BACKGROUND: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. CASE PRESENTATION: A 71-year-old female with general fatigue, central obesity and impaired glucose tolerance was diagnosed with Cushing's syndrome due to elevated ACTH (192...
March 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29581157/regulation-of-mitochondrial-trifunctional-protein-modulates-nonalcoholic-fatty-liver-disease-in-mice
#8
Fatiha Nassir, Justin J Arndt, Sarah A Johnson, Jamal A Ibdah
Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain fatty acids. We previously reported that aging mice (>9-month old) heterozygous for an MTP defect (MTP+/-) develop nonalcoholic fatty liver disease (NAFLD). We tested whether high-fat diet (HFD) accelerates NAFLD in young MTP+/-mice, and whether overexpression of the NAD+-dependent deacetylase SIRT3 deacetylates MTP and improves mitochondrial function and NAFLD. Three-month-old WT and MTP+/- mice were fed HFD (60% cal fat) for 16-weeks and livers were assessed for fatty acid oxidation (FAO) and NAFLD...
March 26, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29580541/wild-lonicera-caerulea-berry-polyphenol-extract-reduces-cholesterol-accumulation-and-enhances-antioxidant-capacity-in-vitro-and-in-vivo
#9
Suwen Liu, Lu You, Yuhua Zhao, Xuedong Chang
The hypocholesterolemic effect of Lonicera caerulea berry extract rich in polyphenols (LCBP) on high cholesterol-induced hypercholesterolemia and lipoprotein metabolite changes was examined in Caco-2 cells and rats. Cyanidin-3-glucoside, catechin, and chlorogenic acid are the major phenolic components of LCBP. The cholesterol-reducing effect and antioxidant capacity of these components were compared in Caco-2 cells. LCBP (80 μg/mL) and cyanidin-3-glucoside, catechin, and chlorogenic acid (50 μM) were found to be effective (p < 0...
May 2018: Food Research International
https://www.readbyqxmd.com/read/29579825/renal-transplantation-in-second-level-private-hospitals-in-the-state-of-mexico
#10
A Armenta Bautista, A Armenta Álvarez, E Mancilla Urrea, G Mondragón, S Aburto Mendoza, R Pérez Mendoza, R González González, M S Escalona Delgado, R Arroyo Borrego, C A Vilchis Canales, C Rocio Lagunas, I Santana Serrano, H Armenta Álvarez, D Valle Ponce
BACKGROUND: Kidney transplantation (KT) is the replacement therapy of choice in patients with end-stage renal disease (ESRD). Here we show a cohort of kidney transplant recipients from the period of May 1994 to May 2016 in 2 2nd-level private hospitals from the city of Toluca in the state of Mexico. METHODS: We checked the clinical files of all the patients that received KT in the period of study. RESULTS: We report 25 KT: 23 performed in Sanatorio Toluca and 2 in Sanatorio Florencia; 16 (64%) male and 9 (26%) female; mean age 36...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29577748/incarcerated-plantar-dislocation-of-the-first-metatarsophalangeal-joint-reduction-using-intra-articular-saline-injection
#11
Daniel D Bohl, Kamran S Hamid, David M Walton
Plantar dislocation of the first metatarsophalangeal (MTP) joint is exceedingly rare, and in prior reported cases, simple closed manipulation easily enabled reduction. We present here the first reported plantar dislocation that failed closed manipulation. We also report a technique involving injection of saline into the joint to facilitate reduction. The saline insufflation likely relieves buttonholing of the metatarsal head through the dorsal joint capsule. For first MTP joint plantar dislocations that fail reduction with manipulation, we recommend attempting injection of the joint with saline prior to subjecting the patient to open reduction...
March 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29575737/the-impact-of-ultrasound-on-the-use-and-efficacy-of-intra-articular-glucocorticoid-injections-in-early-rheumatoid-arthritis-secondary-analyses-from-the-randomised-arctic-trial
#12
Lena B Nordberg, Siri Lillegraven, Anna-Birgitte Aga, Joe Sexton, Elisabeth Lie, Hilde B Hammer, Inge C Olsen, Till Uhlig, Désirée van der Heijde, Tore K Kvien, Espen A Haavardsholm
OBJECTIVE: Intra-articular glucocorticoid injections are common in rheumatoid arthritis (RA) treatment. We aimed to investigate whether ultrasound in combination with clinical examination is better at identifying joints that will benefit from intra-articular injections compared to identification by clinical examination alone, as well as the efficacy of ultrasound-guided versus palpation-guided procedures. METHODS: In the treat-to-target ARCTIC trial, early RA patients were randomised 1:1 to follow-up with or without ultrasound...
March 25, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29569242/egg-yolk-sphingomyelin-and-phosphatidylcholine-attenuate-cholesterol-absorption-in-caco-2-cells
#13
Fang Yang, Guoxun Chen, Meihu Ma, Ning Qiu, Lingjiao Zhu, Jing Li
Phospholipids have been shown to modulate intestinal cholesterol absorption in cells and animals, a process that is regulated by several transporter proteins. Of these proteins, Niemann-Pick C1-Like 1 (NPC1L1) is a major contributor to this process. The mechanism by which phospholipids modulate cholesterol absorption remains unknown. Here, we evaluate the effects of egg-yolk phospholipids on cholesterol absorption and transport in human colon carcinoma cell line (Caco-2 cells) and on the expression of NPC1L1 and others proteins associated with cholesterol absorption (ABCG5, ABCG8, ABCA1, ACAT2, MTP, CAV-1, ANX-2)...
March 22, 2018: Lipids
https://www.readbyqxmd.com/read/29559125/evaluation-of-a-synthetic-peptide-for-the-detection-of-anti-mycobacterium-tuberculosis-curli-pili-igg-antibodies-in-patients-with-pulmonary-tuberculosis
#14
Natasha Naidoo, Balakrishna Pillay, Martin Bubb, Alexander Pym, Thamsanqa Chiliza, Kogieleum Naidoo, Thumbi Ndung'u, Victoria O Kasprowicz, Manormoney Pillay
Tuberculosis (TB) remains a serious threat in underdeveloped areas. Mycobacterium tuberculosis curli pili (MTP), a virulence factor, is a potential biomarker for a reliable point of care (POC) test and was evaluated for its ability to react with Immunoglobulin G (IgG) in TB patients. An MTP synthetic peptide in a slot blot assay was used to screen serum/plasma samples (n = 65) in 3 separate cohorts, including 40 TB positive (16 HIV co-infected), 20 TB negative/HIV negative patients and 5 healthy volunteers...
March 2018: Tuberculosis
https://www.readbyqxmd.com/read/29557095/transcutaneous-oximetry-variability-in-normal-values-for-the-upper-and-lower-limb
#15
Denise F Blake, Derelle A Young, Lawrence H Brown
INTRODUCTION: Published normal transcutaneous oxygen partial pressures (Ptc O2 ) for the chest and lower limb have defined tissue hypoxia as a value of < 40 mmHg (< 30 mmHg in some patients, < 50 mmHg in others). AIM: To determine 'normal' Ptc O2 for the upper and lower limb in healthy, non-smoking adults using the Radiometer® TCM400 with tc Sensor E5250. METHOD: Thirty-two volunteers had transcutaneous oxygen measurements (TCOM) performed on the chest, upper and lower limbs breathing air, with leg then arm elevated and whilst breathing 100% oxygen...
March 31, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29554040/pre-hospital-low-titer-cold-stored-whole-blood-philosophy-for-ubiquitous-utilization-of-o-positive-product-for-emergency-use-in-hemorrhage-due-to-injury
#16
Ashley C McGinity, Caroline S Zhu, Leslie Greebon, Elly Xenakis, Elizabeth Waltman, Eric Epley, Danielle Cobb, Rachelle Jonas, Susannah E Nicholson, Brian J Eastridge, Ronald M Stewart, Donald H Jenkins
The mortality from hemorrhage in trauma patients remains high. Early balanced resuscitation improves survival. These truths, balanced with the availability of local resources and our goals for positive regional impact, were the foundation for the development of our pre-hospital whole blood initiative-using low titer cold stored O RhD positive whole blood (LTOWB). The main concern with use of RhD positive blood is the potential development of isoimmunization in RhD negative patients. We used our retrospective massive transfusion protocol (MTP) data to analyze the anticipated risk of this change in practice...
March 16, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29547028/evaluation-of-the-analgesic-effect-of-combination-therapy-on-chronic-plantar-pain-through-the-myofascial-trigger-points-approach
#17
Rocío Melero-Suárez, José Antonio Sánchez-Santos, Gabriel Domínguez-Maldonado
BACKGROUND: Closely related pathologic disorders sometimes manifest with the same symptoms, making for a complex differential diagnosis. This is the situation in plantar fasciitis (PF) and myofascial pain syndrome (MPS) with myofascial trigger points (MTPs) in the sole of the foot. This research assessed the analgesic effect on plantar pain of combination therapy with interferential current stimulation therapy (ICST), treating MTPs in the great toe adductor muscle and the short flexor muscles of the toes in patients whose diagnosis was compatible with PF or MPS...
January 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29544155/partitioning-ground-reaction-forces-for-multi-segment-foot-joint-kinetics
#18
Dustin A Bruening, Kota Z Takahashi
BACKGROUND: Kinematic multi-segment foot models have been increasingly used to study foot function. The addition of kinetics to these models may enhance their utility; however, this been hindered by limitations in measuring ground reaction forces (GRFs) under individual foot segments. PURPOSE: To determine the accuracy of partitioning segment GRFs from a single force platform on foot joint kinetics. METHODS: Two potential partitioning methods were applied to a previously published three-segment kinetic foot model...
March 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29543459/molecular-dynamic-simulations-for-the-extraction-of-quinoline-from-heptane-in-the-presence-of-low-cost-phosphonium-based-deep-eutectic-solvent
#19
Papu Kumar Naik, Mood Mohan, Tamal Banerjee, Sandip Paul, Vaibhav V Goud
The present study aims at the extraction of polyaromatic hydrocarbon (PAH) from fuel oil using novel low cost deep eutectic solvent (DES). The DES is prepared by mixing the hydrogen bond acceptor (HBA; methyltriphenylphosphonium bromide [MTPB]) and hydrogen bond donor (HBD; ethylene glycol (EG)) at a molar ratio of 1:4. The Liquid-Liquid Equilibrium (LLE) is then measured at ambient condition. The classical Molecular Dynamic (MD) simulation technique is then employed to investigate and compare the experimental phase behavior of DES-quinoline-heptane ternary system...
March 15, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29536155/size-matters-observations-regarding-the-sonographic-double-contour-sign-in-different-joint-sizes-in-acute-gouty-arthritis
#20
C Löffler, H Sattler, U Löffler, B K Krämer, R Bergner
OBJECTIVE: In distinguishing urate arthritis (UA) from non-crystal-related arthritides, joint sonography including the detection of the double contour sign (DCS) and hypervascularization using power Doppler ultrasound (PDUS) is an important step in the diagnostic process. But are these sonographic features equally reliable in every accessible joint under real-life conditions? METHODS: We retrospectively analyzed 362 patients with acute arthritis and evaluated the DCS and the degree of PDUS hypervascularization in patients with gout and in those with arthritis other than urate arthritis (non-UA)...
March 13, 2018: Zeitschrift Für Rheumatologie
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