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https://www.readbyqxmd.com/read/28431141/grade-and-location-of-power-doppler-are-predictive-of-damage-progression-in-rheumatoid-arthritis-patients-in-clinical-remission-by-anti-tumour-necrosis-factor-%C3%AE
#1
Bernd Raffeiner, Enrico Grisan, Costantino Botsios, Roberto Stramare, Gaia Rizzo, Livio Bernardi, Leonardo Punzi, Francesca Ometto, Andrea Doria
Objectives.: To investigate power Doppler (PD) signal, grade and location and their association with radiographic progression in RA patients in remission. Methods: . A prospective observational study was conducted in 125 consecutive RA patients in stable 28-joint DAS (DAS28) remission (⩾6 months) achieved on anti-TNF-α. At baseline, patients in stable remission underwent radiographic and US examination of the wrists and MCP, PIP and MTP joints. Semi-quantitative PD scoring (0-3) was recorded...
April 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28424896/maximum-tongue-pressure-is-associated-with-swallowing-dysfunction-in-als-patients
#2
Aya Hiraoka, Mineka Yoshikawa, Masahiro Nakamori, Naohisa Hosomi, Toshikazu Nagasaki, Takahiro Mori, Masaya Oda, Hirofumi Maruyama, Mitsuyoshi Yoshida, Yuishin Izumi, Masayasu Matsumoto, Kazuhiro Tsuga
Maximum tongue pressure (MTP) measurement is a convenient, less invasive assessment that has been developed to quantify tongue strength; however, it is unclear whether MTP is useful for the detection of swallowing disorders in amyotrophic lateral sclerosis (ALS) patients. The purpose of this study was to clarify the relationship between MTP and the characteristics of swallowing disorders on videofluorography and to determine the usefulness of tongue pressure measurement for the assessment of swallowing function in ALS patients...
April 19, 2017: Dysphagia
https://www.readbyqxmd.com/read/28424137/improvement-of-treatment-outcomes-after-implementation-of-a-massive-transfusion-protocol-a-level-i-trauma-center-experience
#3
Andrew Nunn, Peter Fischer, Ronald Sing, Megan Templin, Michael Avery, A Britton Christmas
We assessed the effectiveness of the implementation of an institutional massive transfusion protocol (MTP) for resuscitation with a 1:1:1 transfusion ratio of packed red blood cell (PRBC), fresh frozen plasma, and platelet units. In a Level I trauma center database, all trauma admissions (2004-2012) that received massive transfusions (≥10 units PRBCs in the first 24 hours) were reviewed retrospectively. Demographic data, transfusion ratios, and outcomes were compared before (PRE) and after (POST) MTP implementation in May 2008...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28419801/on-surface-pseudo-high-dilution-synthesis-of-macrocycles-principle-and-mechanism
#4
Qitang Fan, Tao Wang, Jingya Dai, Julian Kuttner, Gerhard Hilt, J Michael Gottfried, Junfa Zhu
Macrocycles have attracted much attention due to their specific "endless" topology, which results in extraordinary properties compared to related linear (open-chain) molecules. However, challenges still remain in their controlled synthesis with well-defined constitution and geometry. Here, we report the successful application of the (pseudo-)high dilution method to the conditions of on-surface synthesis in ultrahigh vacuum (UHV). This approach leads to high yields (up to 84%) of cyclic hyperbenzene ([18]-honeycombene) via an Ullmann-type reaction from 4,4''-dibromo-meta-terphenyl (DMTP) as precursor on a Ag(111) surface...
April 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28419482/fmea-of-manual-and-automated-methods-for-commissioning-a-radiotherapy-treatment-planning-system
#5
Amy Wexler, Bruce Gu, Sreekrishna Goddu, Maya Mutic, Sridhar Yaddanapudi, Lindsey Olsen, Taylor Harry, Camille Noel, Todd Pawlicki, Sasa Mutic, Bin Cai
PURPOSE: To evaluate the level of risk involved in treatment planning system (TPS) commissioning using a manual test procedure, and to compare the associated process-based risk to that of an automated commissioning process (ACP) by performing an in-depth failure modes and effects analysis (FMEA). METHODS: The authors collaborated to determine the potential failure modes of the TPS commissioning process using 1) approaches involving manual data measurement, modeling, and validation tests HYPERLINK \l "Fra98" 1, HYPERLINK \l "Smi15" 2 and 2) an automated process utilizing application programming interface (API) scripting, pre-loaded and pre-modeled standard radiation beam data, digital heterogeneous phantom, and an automated commissioning test suite (ACTS)...
April 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28416858/study-on-e-coli-and-salmonella-biofilms-from-fresh-fruits-and-vegetables
#6
Balagopal Amrutha, Kothandapani Sundar, Prathapkumar Halady Shetty
Foodborne outbreaks associated with fresh fruits and vegetables are on the rise worldwide. Biofilm formation is one of the important traits of pathogens making them strongly attached to substrates as well as express virulence phenotypes. Present study investigates the biofilm forming ability of E. coli and Salmonella sp. isolated from fresh fruits and vegetables. A total of 53 strains, including 35 E. coli and 18 Salmonella sp. isolated from different fruit and vegetable samples were taken into account for the study...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28410428/tuft1-a-novel-candidate-gene-for-metatarsophalangeal-osteoarthritis-plays-a-role-in-chondrogenesis-on-a-calcium-related-pathway
#7
Eeva Sliz, Mari Taipale, Maiju Welling, Sini Skarp, Viivi Alaraudanjoki, Jaakko Ignatius, Lloyd Ruddock, Ritva Nissi, Minna Männikkö
Osteoarthritis (OA) is the most common degenerative joint disorder and genetic factors have been shown to have a significant role in its etiology. The first metatarsophalangeal joint (MTP I) is highly susceptible to development of OA due to repetitive mechanical stress during walking. We used whole exome sequencing to study genetic defect(s) predisposing to familial early-onset bilateral MTP I OA inherited in an autosomal dominant manner. A nonsynonymous single nucleotide variant rs41310883 (c.524C>T, p...
2017: PloS One
https://www.readbyqxmd.com/read/28394944/identification-of-a-rice-metal-tolerance-protein-osmtp11-as-a-manganese-transporter
#8
Mei Zhang, Baoxiu Liu
Metal tolerance proteins (MTPs) are a gene family of cation efflux transporters that occur widely in plants and might serve an essential role in metal homeostasis and tolerance. Our research describes the identification, characterization, and localization of OsMTP11, a member of the MTP family from rice. OsMTP11 was expressed constitutively and universally in different tissues in rice plant. Heterologous expression in yeast showed that OsMTP11 complemented the hypersensitivity of mutant strains to Mn, and also complemented yeast mutants to other metals, including Co and Ni...
2017: PloS One
https://www.readbyqxmd.com/read/28391704/effect-of-bipartite-hallucal-sesamoid-on-hallux-valgus-surgery
#9
Young Hwan Park, Chan Dong Jeong, Gi Won Choi, Hak Jun Kim
BACKGROUND: Bipartite hallucal sesamoids are often found in patients with hallux valgus. However, it is unknown whether bipartite hallucal sesamoids affect the results of hallux valgus surgery or not. The purpose of the present study was to evaluate the outcomes of chevron osteotomy for hallux valgus with and without bipartite hallucal sesamoid. METHODS: A total of 152 patients (168 feet) treated with distal or proximal chevron osteotomy for hallux valgus constituted the study cohort...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28391422/osteogenic-sarcoma-systemic-chemotherapy-options-for-localized-disease
#10
REVIEW
Douglas J Harrison, Cindy L Schwartz
Treatment for osteosarcoma, the most common malignant tumor of bone in children and adolescents, has not changed in decades. Treatment is multimodal, employing neoadjuvant chemotherapy followed by aggressive and complete surgical resection to achieve negative margins and a prolonged course of adjuvant chemotherapy. The primary tumor is usually successfully managed via surgery, but micrometastases are likely present in most patients at diagnosis. Death is the result of tumor recurrence in the lungs or more rarely in other bones despite aggressive treatment regimens and is likely attributable to innate resistance to chemotherapy...
April 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28382375/-proximal-corrective-osteotomy-correction-of-hallux-valgus-deformity
#11
M Thomas, M Jordan
Severe symptomatic hallux valgus deformities are usually not treatable with conservative methods in the long-term. Surgical treatment currently aims for mechanical restitution of the first ray with preserved mobility of the first metatarsophalangeal (MTP 1) joint and with low risk of recurrence after surgery. Keeping these aims in mind the surgical methods consist of osteotomy at the proximal part of the first metatarsal bone with a high potential for correction of the deformity. Surgical interventions at the midshaft level of the first metatarsal are only useful if the anatomical shape of the metatarsal shows a wide shaft, which allows a large shift in the osteotomy...
April 5, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28367688/first-metatarsophalangeal-contact-properties-following-proximal-opening-wedge-and-scarf-osteotomies-for-hallux-valgus-correction-a-biomechanical-study
#12
Cameron Kia, Ryu Yoshida, Mark Cote, Jessica DiVenere, Lauren E Geaney
BACKGROUND: Proximal opening wedge osteotomy (POWO) is an established procedure for moderate to severe hallux valgus. A common concern of this procedure is that it results in lengthening of the first metatarsal, which could cause increased intra-articular pressure of the first metatarsophalangeal joint (MTP) and may ultimately lead to arthritis because of these altered mechanics. The purpose of this study was to use a cadaveric model to compare intra-articular pressures and articulating contact properties of the MTP joint following either scarf osteotomy or POWO...
April 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28365205/articular-ultrasound-in-asymptomatic-volunteers-identification-of-the-worst-measures-of-synovial-hypertrophy-synovial-blood-flow-and-joint-damage-among-small-medium-%C3%A2-and-large-sized-joints
#13
Flávia Soares Machado, Jamil Natour, Rogerio Diniz Takahashi, Rita N V Furtado
Articular ultrasound of 6500 joint recesses was performed for the purpose of identifying which joint had the highest measurements among small-sized (SSJ), medium-sized (MSJ) and large-sized (LSJ) joints. Quantitative measurements of synovial hypertrophy (QSR) and semiquantitative measurements of synovial hypertrophy (SSH), power Doppler (SPD) and bone erosion (SBE) (score: 0-3) were made. Higher measurements (p < 0.01) of QSR were obtained in the second metatarsophalangeal joint (MTP), talonavicular joint, and hip...
March 29, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28349173/-soft-tissue-techniques-in-hallux-valgus-surgery
#14
H Waizy, B Bouillon, C Stukenborg-Colsman, L Claaßen, K Danniilidis, C Plaaß, D Arbab
The hallux valgus represents combined bony and soft tissue pathology. In addition to known bony surgical procedures, addressing the soft tissue with regard to the anatomical structures, the surgical technique and the extent of correction are discussed.The goal of the operation is the restoration of the physiological balance between the active and passive stabilizing factors of the MTP-I-joint. The joint capsule, the ligaments and the tendons of the first ray act directly as stabilizing structures, whereas the hind foot and the position of the upper ankle have an indirect influence on the MTP-I-joint...
March 27, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28347926/neglected-dorsolateral-dislocation-of-the-first-metatarsophalangeal-joint-a-case-report
#15
Omar A Al-Mohrej, Abdulrahman A AlOmair, Yara A Alfehaid, Abubaker A Alsumali, Nader S Al-Kenani
INTRODUCTION: Although the first metatarsophalangeal (MTP) joint is frequently injured, Complete dislocation of the first MTP joint represents a relatively rare traumatic injury. PRESENTATION OF CASE: A 46-year-old gentleman presented with a traumatic first MTP joint dislocation resulting from an automobile accident. Due to coronavirus outbreak in the hospital at that time, patient was referred to another hospital. Six months later, reduction was achieved surgically and fixation of the MTP with K-wires was done...
February 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28345404/are-bone-bruise-characteristics-and-articular-cartilage-pathology-associated-with-inferior-outcomes-2-and-6-years-after-anterior-cruciate-ligament-reconstruction
#16
Christian Lattermann, Cale A Jacobs, Emily K Reinke, Erica A Scaramuzza, Laura J Huston, Warren R Dunn, Kurt P Spindler
Objective To determine (1) if bone bruise characteristics seen on magnetic resonance imaging are associated with patient-reported outcomes prior to and following anterior cruciate ligament reconstruction and (2) if the combined presence of bone bruises with articular cartilage pathology results in inferior 2- or 6-year outcomes. Design Bone bruise volume and severity were measured on 81 patients' preoperative magnetic resonance imaging in the medial and lateral femoral condyle (MFC, LFC) and medial and lateral tibial plateau (MTP, LTP) using the Costa-Paz classification and a modified version of Roemer and Bohndorf's technique...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28336447/anatomical-reconstruction-of-the-fourth-brachymetatarsia-with-one-stage-iliac-bone-and-cartilage-cap-grafting
#17
Sang-Hyun Woo, Chi Young Bang, Hee-Chan Ahn, Sung-Jung Kim, Jun-Young Choi
BACKGROUND: We present a one-stage procedure for lengthening the fourth brachymetatarsia with autogenous iliac bone and cartilage cap grafting for the anatomical reconstruction of the metatarsophalangeal (MTP) joint METHODS: During the last 8 years, 56 feet in 41 patients with congenital brachymetatarsia of the fourth toe were corrected with a one-stage operation to reposition the articular cartilage cap to the distal part of interpositional iliac bone graft at the metatarsal epiphysis...
February 28, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28335610/rheumatoid-forefoot-reconstruction-in-the-nonrheumatoid-patient
#18
Devon C Nixon, Richard M McKean, Sandra E Klein, Jeffrey E Johnson, Jeremy J McCormick
BACKGROUND: Recurrent pain and deformity following forefoot surgery can cause significant patient disability. In patients with rheumatoid arthritis, first metatarsophalangeal (MTP) joint arthrodesis with lesser metatarsal head resections-termed the rheumatoid forefoot reconstruction-has been shown to be a reliable operation for pain relief and deformity correction. Limited data, however, have been published on outcomes of the same forefoot reconstruction operation in the nonrheumatoid patient...
March 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28316608/expression-of-16-nitrogenase-proteins-within-the-plant-mitochondrial-matrix
#19
Robert S Allen, Kimberley Tilbrook, Andrew C Warden, Peter C Campbell, Vivien Rolland, Surinder P Singh, Craig C Wood
The industrial production and use of nitrogenous fertilizer involves significant environmental and economic costs. Strategies to reduce fertilizer dependency are required to address the world's increasing demand for sustainable food, fibers, and biofuels. Biological nitrogen fixation, a process unique to diazatrophic bacteria, is catalyzed by the nitrogenase complex, and reconstituting this function in plant cells is an ambitious biotechnological strategy to reduce fertilizer use. Here we establish that the full array of biosynthetic and catalytic nitrogenase (Nif) proteins from the diazotroph Klebsiella pneumoniae can be individually expressed as mitochondrial targeting peptide (MTP)-Nif fusions in Nicotiana benthamiana...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28304008/contraception-in-women-with-diabetes
#20
Bharti Kalra, Sanjay Kalra
This brief article covers the diabetes related aspects of contraception in women. It classifies various methods of contraception and describes how presence of diabetes influences their use. The article lists the high risk conditions in diabetes which may discourage use of combined hormonal contraceptives. It discusses the relation of glycaemic control and medical termination of pregnancy (MTP), and calls for universal provision of contraceptive services to all women with diabetes.
March 2017: JPMA. the Journal of the Pakistan Medical Association
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