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https://www.readbyqxmd.com/read/28800058/effectiveness-of-mifamurtide-in-addition-to-standard-chemotherapy-for-high-grade-osteosarcoma-a-systematic-review
#1
Rincy Jimmy, Cindy Stern, Karolina Lisy, Sarahlouise White
BACKGROUND: Osteosarcoma mostly occurs during the period of rapid bone growth in children and adolescents as high-grade osteosarcomas. Current treatment recommended for high-grade non-metastatic and metastatic and/or relapsed osteosarcoma involves neoadjuvant multiagent conventional chemotherapy, followed by surgical resection of macroscopically detected tumor and postoperative adjuvant chemotherapy. However, residual micrometastatic deposits that develop following surgery have shown resistance to postoperative/adjuvant chemotherapy...
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28793320/microsomal-triglyceride-transfer-protein-contributes-to-lipid-droplet-maturation-in-adipocytes
#2
Larry L Swift, Joseph D Love, Carla M Harris, Benny H Chang, W Gray Jerome
Previous studies in our laboratory have established the presence of MTP in both white and brown adipose tissue in mice as well as in 3T3-L1 cells. Additional studies demonstrated an increase in MTP levels as 3T3-L1 cells differentiate into adipocytes concurrent with the movement of MTP from the juxtanuclear region of the cell to the surface of lipid droplets. This suggested a role for MTP in lipid droplet biogenesis and/or maturation. To probe the role of MTP in adipocytes, we used a Cre-Lox approach with aP2-Cre and Adipoq-Cre recombinase transgenic mice to knock down MTP expression in brown and white fat of mice...
2017: PloS One
https://www.readbyqxmd.com/read/28777419/the-neutraclear%C3%A2-needleless-connector-is-equally-effective-against-catheter-colonization-compared-to-microclave%C3%A2
#3
María Guembe, María Jesús Pérez Granda, Raquel Cruces, Luis Alcalá, Emilio Bouza
INTRODUCTION: Neutral-valve closed-system connectors can reduce the frequency of catheter colonization. Commercially available closed system connectors need to be tested and compared with each other to assess how they protect against contamination. We aimed to compare, in vitro, the efficacy of connectors NeutraClear® and MicroClave® against contamination under conditions of daily clinical practice. METHODS: The model consisted of a set of 200 blood culture bottles (BCBs) with a cannula inserted (100 closed with NeutraClear® and 100 closed with MicroClave®) that were assessed in two experiments while instilling 1 mL of saline: manipulation based on the standard of care and manipulation using gloves impregnated with a 0...
July 29, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28772238/eco-friendly-fabrication-of-ag-nanostructures-using-the-seed-extract-of-pedalium-murex-an-ancient-indian-medicinal-plant-histopathological-effects-on-the-zika-virus-vector-aedes-aegypti-and-inhibition-of-biofilm-forming-pathogenic-bacteria
#4
Ramachandran Ishwarya, Baskaralingam Vaseeharan, Ramasamy Anuradha, Ravichandran Rekha, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
The control of Zika virus mosquito vectors and well as the development of drugs in the fight against biofilm-forming microbial pathogens, are timely and important challenges in current bionanoscience. Here we focused on the eco-friendly fabrication of Ag nanostructures using the seed extract of Pedalium murex, an ancient Indian medicinal plant. Initial confirmation of Ag nanoparticles (AgNPs) production was showed by a color change from transparent to dark brown. The UV-Visible spectrum (476nm), X-ray diffraction peaks (101, 200, 220 and 311) and Fourier transform infrared spectroscopy shed light on the production of green-capped AgNPs...
July 25, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28771656/transfusion-practice-in-trauma-resuscitation
#5
Ashley M Eckel, John R Hess
Recognition of the acute coagulopathy of trauma and the limits of reconstituting whole blood with conventional blood components has led to a radical change in the way trauma patients with severe injuries are resuscitated. Massive transfusion protocols (MTP) have evolved toward the administration of conventional blood components in fixed ratios. Administration of a 1:1:1 unit ratio of fresh frozen plasma to whole-blood-derived platelets to packed red blood cells is now the most common strategy and the stated goal of directors of >80% of the level I trauma centers in the United States...
August 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28768212/effects-of-biosolids-from-a-wastewater-treatment-plant-receiving-manufactured-nanomaterials-on-medicago-truncatula-and-associated-soil-microbial-communities-at-low-nanomaterial-concentrations
#6
Chun Chen, Olga V Tsyusko, Dave H McNear, Jonathan Judy, Ricky W Lewis, Jason M Unrine
Concern has grown regarding engineered nanomaterials (ENMs) entering agricultural soils through the application of biosolids and their possible effects on agroecosystems, even though the ENMs are extensively transformed. The effects of exposure to biosolids containing transformation products of these ENMs at low concentrations remain largely unexplored. We examined the responses of Medicago truncatula and its symbiotic rhizobia Sinorhizobium meliloti exposed to soil amended with biosolids from WWTP containing low added concentrations of ENMs (ENM Low), bulk/dissolved metals (bulk/dissolved Low), or no metal additions (control)...
July 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28764248/wunderlich-syndrome-due-to-ruptured-pseudoaneurysm-of-angiomyolipoma-in-first-trimester-a-rare-case-report
#7
Sunil Raghunath Patil, Prakash Wamanrao Pawar, Ajit Somaji Sawant, Abhishek Jaysukhbhai Savalia, Ashwin Sunil Tamhankar
Angiomyolipoma (AML) is a rare benign tumour of kidney which demonstrates rapid growth during pregnancy due to hormonal stimulation, leading to rupture. Majority of reported ruptured AMLs are in third trimester. We report a case of ruptured angiomyolipoma at 10th week of gestation, the earliest rupture known in singleton pregnancy. The AML had pseudo-aneurysm formation with extra-tumoural rupture during pregnancy, a finding never reported in literature yet. The patient had active bleeding with expanding peri-nephric haematoma during initial two days of conservative management...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763157/a-unifying-mathematical-model-of-lipid-droplet-metabolism-reveals-key-molecular-players-in-the-development-of-hepatic-steatosis
#8
Christin Wallstab, Dimitra Eleftheriadou, Theresa Schulz, Georg Damm, Daniel Seehofer, Jürgen Borlak, Hermann-Georg Holzhütter, Nikolaus Berndt
The liver responds to elevated plasma concentrations of free fatty acids (FFAs) with an enhanced uptake of FFAs and their esterification to triacylglycerol (TAG). On the long term this may result in massive hepatic TAG accumulation called steatosis hepatitis. In hepatocytes, the poor water-soluble TAG is packed in specialized organelles: Lipid droplets (LDs) serving as transient cellular deposit and lipoproteins (LPs) transporting TAG and cholesterol esters to extra-hepatic tissues. The dynamics of these organelles is controlled by a variety of regulatory surface proteins (RSPs)...
August 1, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28762464/the-mid-point-transverse-process-to-pleura-mtp-block-a-new-end-point-for-thoracic-paravertebral-block
#9
I Costache, L de Neumann, C J Ramnanan, S L Goodwin, A Pawa, F W Abdallah, C J L McCartney
Current descriptions of thoracic paravertebral block techniques require the needle tip to be anterior to the superior costotransverse ligament. We hypothesised that an injection point midway between the posterior border of the transverse process and the pleura would result in spread to the paravertebral space. We completed bilateral injections of 5 ml methylene blue 0.2% midway between the posterior border of the transverse process and the pleura at T2, T4, T6, T8 and T10 in three unembalmed cadavers. The presence of methylene blue dye at the nerve root in the paravertebral space, the corresponding intercostal nerve and sympathetic chain at the level of injection, and at additional levels, was examined...
August 1, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28760553/genome-wide-identification-of-sweet-orange-citrus-sinensis-metal-tolerance-proteins-and-analysis-of-their-expression-patterns-under-zinc-manganese-copper-and-cadmium-toxicity
#10
Xing-Zheng Fu, Ya-Hua Tong, Xue Zhou, Li-Li Ling, Chang-Pin Chun, Li Cao, Ming Zeng, Liang-Zhi Peng
Plant metal tolerance proteins (MTPs) play important roles in heavy metal homeostasis; however, related information in citrus plants is limited. Citrus genome sequencing and assembly have enabled us to perform a systematic analysis of the MTP gene family. We identified 12 MTP genes in sweet orange, which we have named as CitMTP1 and CitMTP3 to CitMTP12 based on their sequence similarity to Arabidopsis thaliana MTPs. The CitMTPs were predicted to encode proteins of 864 to 2556 amino acids in length that included 4 to 6 putative transmembrane domains (TMDs)...
July 28, 2017: Gene
https://www.readbyqxmd.com/read/28751256/inter-and-intraexaminer-reliability-in-identifying-and-classifying-myofascial-trigger-points-in-shoulder-muscles
#11
José Diego Sales do Nascimento, Francisco Alburquerque-Sendín, Lorena Passos Vigolvino, Wandemberg Fortunato de Oliveira, Catarina de Oliveira Sousa
OBJECTIVE: To determine inter and intraexaminer reliability of examiners without clinical experience in identifying and classifying MTPs in the shoulder muscles of subjects asymptomatic and symptomatic for unilateral SIS. DESIGN: Within-day inter and intraexaminer reliability study. SETTING: Physical Therapy Department of a University. PARTICIPANTS: Fifty-two subjects participated in the study, 26 symptomatic (SG) and 26 asymptomatic (AG) for unilateral SIS...
July 24, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28720138/plantar-plate-pathology-is-associated-with-erosive-disease-in-the-painful-forefoot-of-patients-with-rheumatoid-arthritis
#12
Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield, Philip S Helliwell
BACKGROUND: Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the metatarsophalangeal (MTP) joints are the most common site of symptoms. The plantar plates are the fibrocartilaginous distal attachments of the plantar fascia inserting into the five proximal phalanges. Together with the transverse metatarsal ligament they prevent splaying of the forefoot and subluxation of the MTP joints...
July 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28719428/blood-product-utilization-among-trauma-and-nontrauma-massive-transfusion-protocols-at-an-urban-academic-medical-center
#13
Eshan U Patel, Paul M Ness, Christi E Marshall, Thomas Gniadek, David T Efron, Peter M Miller, Joseph A Zeitouni, Karen E King, Evan M Bloch, Aaron A R Tobian
BACKGROUND: Hospital-wide massive transfusion protocols (MTPs) primarily designed for trauma patients may lead to excess blood products being prepared for nontrauma patients. This study characterized blood product utilization among distinct trauma and nontrauma MTPs at a large, urban academic medical center. METHODS: A retrospective study of blood product utilization was conducted in patients who required an MTP activation between January 2011 and December 2015 at an urban academic medical center...
September 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28714669/interconnected-hierarchical-zsm-5-with-tunable-acidity-prepared-by-a-dealumination-realumination-process-a-superior-mtp-catalyst
#14
Junjie Li, Min Liu, Xinwen Guo, Shutao Xu, Yingxu Wei, Zhongmin Liu, Chunshan Song
ZSM-5 that uses TPAOH as a template has an Al-rich exterior and defective Si-rich interior; thus, a simple base leaching selectively removed the Si-rich interior while the Al-rich exterior was protected. This catalyst showed no change in stability comparing with parent ZSM-5 during the MTP reaction that was attributed to the enclosed hollow structure and richly acidic outer shell. A preliminary fluorination, however, both removed defective Si-sites and caused distortion in tetrahedral aluminum that made the outer shell susceptible to alkaline treatment...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28714106/prevalence-and-distribution-of-sesamoid-bones-and-accessory-ossicles-of-the-foot-as-determined-by-digital-tomosynthesis
#15
Bon San Koo, Yoonah Song, Seunghun Lee, Yoon-Kyoung Sung, Il-Hoon Sung, Jae-Bum Jun
We previously reported that digital tomosynthesis (DTS) is a reliable tool for evaluating bony structures of the hand. The current study aimed to identify the prevalence and distribution of sesamoid bones and accessory ossicles of the foot using DTS and to compare the results to those of conventional radiography (CR). Foot images (DTS, 213; CR, 44) of 213 patients taken at a tertiary hospital were retrospectively reviewed. Sesamoid bones were identified in the metatarsaophalangeal (MTP), distal interphalangeal (DIP) and interphalangeal (IP) joints of the great (I), second (II), third (III), fourth (IV), and fifth (V) toes...
July 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28702990/relationship-between-amphipathic-%C3%AE-structures-in-the-%C3%AE-1-domain-of-apolipoprotein-b-and-the-properties-of-the-secreted-lipoprotein-particles-in-mca-rh7777-cells
#16
COMPARATIVE STUDY
Medha Manchekar, Richa Kapil, Zhihuan Sun, Jere P Segrest, Nassrin Dashti
Our previous studies demonstrated that the first 1000 amino acid residues (the βα1 domain) of human apolipoprotein (apo) B-100, termed apoB:1000, are required for the initiation of lipoprotein assembly and the formation of a monodisperse stable phospholipid (PL)-rich particle. The objectives of this study were (a) to assess the effects on the properties of apoB truncates undergoing sequential inclusion of the amphipathic β strands in the 700 N-terminal residues of the β1 domain of apoB-100 and (b) to identify the subdomain in the β1 domain that is required for the formation of a microsomal triglyceride transfer protein (MTP)-dependent triacylglycerol (TAG)-rich apoB-containing particle...
August 8, 2017: Biochemistry
https://www.readbyqxmd.com/read/28696376/lack-of-additive-effects-of-resveratrol-and-energy-restriction-in-the-treatment-of-hepatic-steatosis-in-rats
#17
Iñaki Milton-Laskibar, Leixuri Aguirre, Alfredo Fernández-Quintela, Anabela P Rolo, João Soeiro Teodoro, Carlos M Palmeira, María P Portillo
The aims of the present study were to analyze the effect of resveratrol on liver steatosis in obese rats, to compare the effects induced by resveratrol and energy restriction and to research potential additive effects. Rats were initially fed a high-fat high-sucrose diet for six weeks and then allocated in four experimental groups fed a standard diet: a control group, a resveratrol-treated group, an energy restricted group and a group submitted to energy restriction and treated with resveratrol. We measured liver triacylglycerols, transaminases, FAS, MTP, CPT1a, CS, COX, SDH and ATP synthase activities, FATP2/FATP5, DGAT2, PPARα, SIRT1, UCP2 protein expressions, ACC and AMPK phosphorylation and PGC1α deacetylation...
July 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28694515/physical-binding-of-endothelial-mcam-and-neural-transmembrane-protease-matriptase-novel-cell-adhesion-in-neural-stem-cell-vascular-niche
#18
Hsiu-Hui Tung, Sheau-Ling Lee
Brain neural stem cells and transit amplifying cells in the subventricular zone (SVZ) of the lateral ventricles are in direct contact with the microvascular endothelium. The mechanisms/molecules of direct cell contact in the SVZ neurovascular niche are not fully understood. We previously showed that neural stem/progenitor (NS/P) cells induce brain endothelial signaling in direct cell contact through matriptase (MTP) on NS/P cell surface. In the present study, using pull-down and LC-MS/MS, we identified melanoma cell adhesion molecule (MCAM) the brain endothelial molecule that interacts with MTP...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28688890/any-changes-in-recent-massive-transfusion-practices-in-a-tertiary-level-institution
#19
Romi Sinha, David Roxby
BACKGROUND & OBJECTIVES: A previous review of transfusion practices in our institution between 1998 and 2008 showed a trend of high ratios of red cells (RC) to plasma (FFP) and platelets to RC towards the later years of review period. The aim of the study was to further evaluate transfusion practices in the form of blood product usage and outcomes following massive transfusion (MT) METHODS: All adult patients with critical bleeding who received a MT (defined as ≥10 units of RC in 24h) in 2008 and between January 2010 and December 2014 were identified...
June 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28686846/effect-of-first-tarsometatarsal-joint-derotational-arthrodesis-on-first-ray-dynamic-stability-compared-to-distal-chevron-osteotomy
#20
Tero Klemola, Juhana Leppilahti, Vesa Laine, Ilkka Pentikäinen, Risto Ojala, Pasi Ohtonen, Olli Savola
BACKGROUND: Hallux valgus alters gait, compromising first ray stability and function of the windlass mechanism at the late stance. Hallux valgus correction should restore the stability of the first metatarsal. Comparative studies reporting the impact of different hallux valgus correction methods on gait are rare. We report the results of a case-control study between distal chevron osteotomy and first tarsometatarsal joint derotational arthrodesis (FTJDA). METHODS: Two previously studied hallux valgus cohorts were matched: distal chevron osteotomy and FTJDA...
August 2017: Foot & Ankle International
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