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https://www.readbyqxmd.com/read/27912768/quasi-continuous-parallel-online-scattered-light-fluorescence-and-dissolved-oxygen-tension-measurement-combined-with-monitoring-of-the-oxygen-transfer-rate-in-each-well-of-a-shaken-microtiter-plate
#1
Tobias Ladner, Markus Held, David Flitsch, Mario Beckers, Jochen Büchs
BACKGROUND: Microtiter plates (MTP) are often applied as culture vessels in high-throughput screening programs. If online measuring techniques are available, MTPs can also be applied in the first steps of process development. For such small-scale bioreactors dipping probes are usually too large; therefore, optical measurements are often used. For example, the BioLector technology allows for the online monitoring of scattered light and fluorescence in each well of a continuously orbitally shaken MTP...
December 3, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27909032/midterm-outcomes-of-polyvinyl-alcohol-hydrogel-hemiarthroplasty-of-the-first-metatarsophalangeal-joint-in-advanced-hallux-rigidus
#2
Timothy R Daniels, Alastair S E Younger, Murray J Penner, Kevin J Wing, Sara Lyn Miniaci-Coxhead, Ellie Pinsker, Mark Glazebrook
BACKGROUND: Hallux rigidus is the most common arthritic condition of the foot. A randomized clinical trial of first metatarsophalangeal (MTP) joint hemiarthroplasty with a polyvinyl alcohol (PVA) hydrogel implant (Cartiva) demonstrated pain relief and functional outcomes equivalent to first MTP arthrodesis at 2 years postoperation, with no cases of implant fragmentation, wear, or bone loss. We prospectively determined 5-year outcomes of first MTP hemiarthroplasty with the PVA hydrogel implant...
November 30, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27905203/efficacy-and-toxicity-of-the-combination-chemotherapy-of-thalidomide-alkylating-agent-and-steroid-for-relapsed-refractory-myeloma-patients-a-report-from-the-korean-multiple-myeloma-working-party-kmmwp-retrospective-study
#3
Jihyun Kwon, Chang-Ki Min, Kihyun Kim, Jae-Joon Han, Joon Ho Moon, Hye Jin Kang, Hyeon-Seok Eom, Min Kyoung Kim, Hyo Jung Kim, Dok Hyun Yoon, Jeong-Ok Lee, Won Sik Lee, Jae Hoon Lee, Je-Jung Lee, Yoon-Seok Choi, Sung Hyun Kim, Sung-Soo Yoon
We analyzed the treatment responses, toxicities, and survival outcomes of patients with relapsed or refractory multiple myeloma who received daily thalidomide, cyclophosphamide, and dexamethasone (CTD) or daily thalidomide, melphalan, and prednisolone (MTP) at 17 medical centers in Korea. Three-hundred and seventy-six patients were enrolled. The combined chemotherapy of thalidomide, corticosteroid, and an alkylating agent (TAS) was second-line chemotherapy in 142 (37.8%) patients, and third-line chemotherapy in 135 (35...
December 1, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27903452/%C3%AE-glucan-induced-cortisol-levels-improve-the-early-immune-response-in-matrinx%C3%A3-brycon-amazonicus
#4
Luz N Franco Montoya, Talísia P Martins, Rodrigo Y Gimbo, Fábio S Zanuzzo, Elisabeth C Urbinati
This study investigated the role of endogenous cortisol on the innate immune response in matrinxã (Brycon amazonicus) fed with β-glucan, prior to and after stressor exposure and bacterial challenge. For this, we evaluated the serum cortisol and plasma glucose levels, the serum lysozyme levels, the hemolytic activity of the complement system, and the respiratory activity of leukocytes, as well as the number of circulating erythrocytes and leukocytes of fish fed during 15 days with diets containing β-glucan 0...
November 27, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27894248/crystal-structure-of-murein-tripeptide-amidase-mpaa-from-escherichia-coli-o157-at-2-6-%C3%A3-resolution
#5
Yinliang Ma, Guohui Bai, Yaqi Cui, Jing Zhao, Zenglin Yuan, Xiuhua Liu
Peptidoglycan (PG) is an essential component of the cell wall, and undergoes reconstruction by various PG hydrolases during cell growth, development and division. The murein- tripeptide (Mtp) amidase MpaA belongs to PG hydrolase family and is responsible for cleaving the γ-D-Glu-meso-Dap amide bond in the Mtp released during PG turnover. The current paper reports the crystal structure of MpaA from Escherichia coli (E. coli) O157 at 2.6 Å resolution. The asymmetric unit consists of two protein molecules and each monomer represents the common α/β fold of metallo-carboxypeptidases (MCP)...
November 28, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27893158/articular-cartilage-scores-in-cranial-cruciate-ligament-deficient-dogs-with-or-without-bucket-handle-tears-of-the-medial-meniscus
#6
Kathryn Kaufman, Brian S Beale, Howard D Thames, W Brian Saunders
OBJECTIVE: To compare articular cartilage scores in cranial cruciate ligament (CCL)-deficient dogs with or without concurrent bucket handle tears (BHT) of the medial meniscus. STUDY DESIGN: Retrospective case series. ANIMALS: Client-owned dogs treated with arthroscopy and tibial plateau leveling osteotomy or extracapsular repair for complete CCL rupture (290 stifles from 264 dogs). METHODS: Medical records and arthroscopic images were reviewed...
November 28, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27888844/mr-imaging-of-the-plantar-plate-normal-anatomy-turf-toe-and-other-injuries
#7
REVIEW
Caio Nery, Daniel Baumfeld, Hilary Umans, André F Yamada
The metatarsophalangeal (MTP) joint complex is a weight-bearing structure important to the biomechanics of the standing position, walking, shoe wearing, and sport participation. Acute dorsiflexion injury of the first MTP joint, "turf toe," is common among American football and soccer players. The first and lesser MTP joint complexes can be affected by degenerative or inflammatory arthritis, infarct, and infection. These conditions can lead to plantar plate disruption. Imaging studies help physicians to properly diagnose and treat this condition...
February 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27865164/metformin-improves-lipid-metabolism-disorders-through-reducing-the-expression-of-microsomal-triglyceride-transfer-protein-in-oletf-rats
#8
Nianhong Wang, Junqing Zhang, Yiming Wu, Jia Liu, Lin Liu, Xiaohui Guo
OBJECTIVE: This study aimed to investigate the role of MTP on lipid metabolism disorders in insulin-resistant rats and the potential mechanism through which metformin can improve lipid metabolism disorders. METHODS: 30 OLETF rats served as research subjects and 18 LETO rats of the same strain served as the control group (LETO group). After the first oral glucose tolerance test (at 8-week-old), 6 rats were randomly killed from each group. The remaining 24 OLETF rats were randomly divided into untreated group (OLETF group) and treated group (OLETF/M group, cured with metformin)...
October 15, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27861365/effects-of-balance-taping-using-kinesiology-tape-in-a-patient-with-moderate-hallux-valgus-a-case-report
#9
Sun-Min Lee, Jung-Hoon Lee
BACKGROUND: Hallux valgus, an increased angle of lateral deviation in the big toe, can cause pain and difficulties in balancing and walking. This study aimed to investigate the effects of balance taping using elastic therapeutic tape on moderate hallux valgus. METHODS: When she walked with shoes, she complained of pain over the medial eminence of the hallux metatarsophalangeal (MTP) joint. Balance taping using kinesiology tape was applied for 3 months (average, 16hours/d) to both big toes of a 26-year-old woman with moderate hallux valgus...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27852647/plantar-plate-repair-for-lesser-metatarsophalangeal-joint-instability
#10
Wesley W Flint, David M Macias, James R Jastifer, Jesse F Doty, Christopher B Hirose, Michael J Coughlin
BACKGROUND: Lesser metatarsophalangeal (MTP) joint instability is a common cause of forefoot pain. Advances in operative technique and instrumentation have made it possible to anatomically treat plantar plate tears through a dorsal approach. Our goal was to evaluate the subjective, functional, and radiographic outcomes of plantar plate repair (PPR) from a dorsal approach. METHODS: A prospective case series was performed evaluating the results of PPR in 97 feet with 138 plantar plate tears...
November 15, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27832671/exercise-based-cardiac-rehabilitation-in-coronary-disease-training-impulse-or-modalities
#11
P-M Leprêtre, M Ghannem, M Bulvestre, S Ahmaidi, S Delanaud, T Weissland, P Lopes
To compare the effects of 2 short programs with similar training load (TL), based on combined aerobic - resistance training (CT) or aerobic training (AT) on cardiorespiratory responses, 32 patients with coronary heart disease (CHD: 63.8±8.0y, 1.73±0.06 m, 84.8±15.9 kg, Left Ventricular Ejection Fraction: 0.53±0.8) performed 4 weeks of exercise rehabilitation based on CT (n=16) or AT (n=16). Maximal tolerated power (MTP), peak values of oxygen uptake (VO2peak) and heart rate (HRpeak), anaerobic threshold (VT1) were determined during an incremental cycling exercise test before and after training periods...
November 10, 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27803965/the-role-of-ultrasound-in-diagnosing-rheumatoid-arthritis-what-do-we-know-an-updated-review
#12
REVIEW
Philip Rask Lage-Hansen, Hanne Lindegaard, Stavros Chrysidis, Lene Terslev
To clarify if musculoskeletal ultrasound (MSUS) improves early diagnosis of RA when added to the clinical examination of patients with possible arthritis. We performed a systematic literature review of original studies dealing with the value of MSUS in the early diagnosis of RA. Studies were identified using the databases of PubMed, EMBASE and Cochrane library. Only studies in English investigating populations with non-classified arthritis or arthralgia were included. Fifteen original studies investigating the added value of MSUS in diagnosing RA were identified...
November 1, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27803304/relationship-of-bone-erosion-with-the-urate-and-soft-tissue-components-of-the-tophus-in-gout-a-dual-energy-computed-tomography-study
#13
Mark Sapsford, Gregory D Gamble, Opetaia Aati, Julie Knight, Anne Horne, Anthony J Doyle, Nicola Dalbeth
OBJECTIVES: Imaging and pathology studies have established a close relationship between tophus and bone erosion in gout. The tophus is an organized structure consisting of urate crystals and chronic inflammatory tissue. The aim of this work was to examine the relationship between bone erosion and each component of the tophus. METHODS: Plain radiographs and dual energy CT scans of the feet were prospectively obtained from 92 people with tophaceous gout. The 10 MTP joints were scored for erosion score, tophus urate and soft tissue volume...
November 1, 2016: Rheumatology
https://www.readbyqxmd.com/read/27796995/liver-metabolic-disruption-induced-after-a-single-exposure-to-pcb126-in-rats
#14
Natalie A Chapados, Marie-Pier Boucher
Polychlorinated biphenyls (PCBs) have been recognized as metabolic disruptors. The liver plays a pivotal role in detoxification of an organism. Fatty liver results from altered intra-, and extra-hepatic mediators and is associated with increased glucose-related protein 78 (GRP78), commonly used as a marker for endoplasmic reticulum (ER) stress signaling. This pilot study aimed to study the effects of a single exposure on fatty liver metabolic parameters. The objective of the study is to characterize the effects of 3,3',4,4',5-pentachlorobiphenyl (PCB126) on ER stress protein chaperon GRP78 and CCAAT-enhancer-binding protein homologous protein (CHOP) and intra-hepatic mediators such as microsomal triglyceride transfer protein (MTP), sterol regulatory element-binding protein 1c (SREBP1c), and peroxisome proliferator-activated receptor alpha (PPARα), as well as extra-hepatic factors such as non-esterified fatty acid (NEFA) and tumor necrosis factor alpha (TNFα)...
October 31, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27795735/respiration-activity-monitoring-system-for-any-individual-well-of-a-48-well-microtiter-plate
#15
David Flitsch, Sebastian Krabbe, Tobias Ladner, Mario Beckers, Jana Schilling, Stefan Mahr, Uwe Conrath, Werner K Schomburg, Jochen Büchs
BACKGROUND: Small-scale micro-bioreactors have become the cultivation vessel of choice during the first steps of bioprocess development. They combine high cultivation throughput with enhanced cost efficiency per cultivation. To gain the most possible information in the early phases of process development, online monitoring of important process parameters is highly advantageous. One of these important process parameters is the oxygen transfer rate (OTR). Measurement of the OTR, however, is only available for small-scale fermentations in shake flasks via the established RAMOS technology until now...
2016: Journal of Biological Engineering
https://www.readbyqxmd.com/read/27779982/impact-of-massive-transfusion-and-aging-blood-in-acute-trauma
#16
Tanya Anand, Rajesh Ramnanan, Ruby Skinner, Maureen Martin
Blood transfusions cause altered immunity and the duration of storage is contributory. In the era of massive transfusion protocols (MTPs) this impact is unclear, particularly as it relates to balanced transfusions. Trauma patients requiring our MTP after admission to our Level II trauma center were studied. The average age of blood transfused was calculated; old blood was a storage time of ≥14 days versus new blood <14 days. Blood to plasma ratios of 1:1 were compared with ratios >1:1. Infections, organ dysfunction multiorgan injury (MOI), and death were compared based on ratios and blood storage times...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27774614/blood-component-transfusion-and-wastage-rates-in-the-setting-of-massive-transfusion-in-three-regional-trauma-centers
#17
Nancy M Dunbar, Nicholas J Olson, Zbigniew M Szczepiorkowski, Eric D Martin, Ryan M Tysarcyk, Darrell J Triulzi, Louis H Alarcon, Mark H Yazer
BACKGROUND: The purpose of massive transfusion protocols (MTPs) is to provide large quantities of blood products rapidly to exsanguinating patients. The expected rates of blood product transfusion and wastage in this setting have not been defined. This study was undertaken to assess the transfusion and wastage rates for bleeding patients requiring emergency issue of blood components at three American Level I trauma centers. STUDY DESIGN AND METHODS: Three hospitals participated, all of which are Level I trauma centers that have MTPs in place where uncrossmatched red blood cells (RBCs) can be ordered with or without platelets (PLTs), plasma, and cryoprecipitate...
October 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27765484/sequencing-and-comparative-analysis-of-aegilops-tauschii-chromosome-arm-3ds-reveal-rapid-evolution-of-triticeae-genomes
#18
Jingzhong Xie, Naxin Huo, Shenghui Zhou, Yi Wang, Guanghao Guo, Karin R Deal, Shuhong Ouyang, Yong Liang, Zhenzhong Wang, Lichan Xiao, Tingting Zhu, Tiezhu Hu, Vijay Tiwari, Jianwei Zhang, Hongxia Li, Zhongfu Ni, Yingyin Yao, Huiru Peng, Shengli Zhang, Olin D Anderson, Patrick E McGuire, Jan Dvorak, Ming-Cheng Luo, Zhiyong Liu, Yong Q Gu, Qixin Sun
Bread wheat (Triticum aestivum, AABBDD) is an allohexaploid species derived from two rounds of interspecific hybridizations. A high-quality genome sequence assembly of diploid Aegilops tauschii, the donor of the wheat D genome, will provide a useful platform to study polyploid wheat evolution. A combined approach of BAC pooling and next-generation sequencing technology was employed to sequence the minimum tiling path (MTP) of 3176 BAC clones from the short arm of Ae. tauschii chromosome 3 (At3DS). The final assembly of 135 super-scaffolds with an N50 of 4...
October 5, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27763775/reliability-of-haemophilus-influenzae-biofilm-measurement-via-static-method-and-determinants-of-in-vitro-biofilm-production
#19
Najla A Obaid, Stephen Tristram, Christian K Narkowicz, Glenn A Jacobson
Information is lacking regarding the precision of microtitre plate (MTP) assays used to measure biofilm. This study investigated the precision of an MTP assay to measure biofilm production by nontypeable Haemophilus influenzae (NTHi) and the effects of frozen storage and inoculation technique on biofilm production. The density of bacterial final growth was determined by absorbance after 18-20 h incubation, and biofilm production was then measured by absorbance after crystal violet staining. Biofilm formation was categorised as high and low for each strain...
December 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/27749352/massive-transfusion-protocols-a-survey-of-academic-medical-centers-in-the-united-states
#20
Angela B Treml, Jed B Gorlin, Richard P Dutton, Barbara M Scavone
BACKGROUND: Massive transfusion protocols (MTPs) have been adopted in many hospitals, and they may improve outcomes, as well as decrease the number of blood products transfused. However, there are no specific guidelines regarding the number and types of products that should be included in these protocols. MTPs may vary from hospital to hospital. METHODS: A short, web-based survey was sent to blood bank medical directors at academic institutions to learn details about MTPs...
October 3, 2016: Anesthesia and Analgesia
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