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https://www.readbyqxmd.com/read/28620733/management-of-congenital-diaphragmatic-hernia-in-newborn-paradigm-shift-and-ethical-issues
#1
Sushmita Nitin Bhatnagar, Yogesh Kumar Sarin
Management of congenital diaphragmatic hernia (CDH) begins soon after it is detected, whether antenatally or postnatally. Assessment of the severity of the condition, associated congenital anomalies, maternal health and related issues, weight of the fetus/baby, mode of delivery, timing of delivery, immediate appropriate management of the baby with CDH at birth, appropriate utilization of available treatment modalities as well as infrastructure of the treating institute have an impact on the outcome of the neonate...
June 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28608725/driving-after-hallux-valgus-surgery
#2
Elizabeth McDonald, Rachel Shakked, Joseph Daniel, David I Pedowitz, Brian S Winters, Christopher Reb, Mary-Katherine Lynch, Steven M Raikin
BACKGROUND: The purpose of the study was to determine when patients can safely return to driving after first metatarsal osteotomy for hallux valgus correction. METHODS: After institutional review board approval, 60 patients undergoing right first metatarsal osteotomy for hallux valgus correction surgery were recruited prospectively. Patients' brake reaction time (BRT) was tested at 6 weeks and repeated until patients achieved a passing BRT. A control group of twenty healthy patients was used to establish as passing BRT...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28607766/hallux-rigidus
#3
REVIEW
Bryant Ho, Judith Baumhauer
An estimated 40% of the US population have foot problems.Of all patients aged over 50 years, 2.5% report degenerative arthritis of the first metatarsophalangeal (MTP) joint, termed 'hallux rigidus'. First MTP osteoarthritis is the most common arthritic condition in the foot.Progression of great toe arthritis is associated with pain and loss of motion. Non-surgical intervention begins with shoe modifications and orthotics designed to limit MTP motion.In patients with mild arthritis, operative procedures focus on removing excess osteophytes (cheilectomy) to prevent dorsal impingement with or without a concomitant osteotomy (Moberg) to improve or shift range of motion into a less painful arc...
January 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28601811/microsomal-triglyceride-transfer-protein-mtp-in-the-ectoparasitic-crustacean-salmon-louse-l-salmonis
#4
Muhammad Tanveer Khan, Sussie Dalvin, Frank Nilsen, Rune Male
The salmon louse Lepeophtheirus salmonis is a challenging ectoparasite for the salmon farming industry and wild salmonids. Salmon lice have a very high reproductive output, that require deposition of large amounts of lipids into growing oocytes as a major energy source, most probably mediated by lipoproteins. Microsomal triglyceride transfer protein (MTP) is essential for the assembly of lipoproteins. Salmon lice have three LsMTP transcript variants encoding two different protein isoforms predicted to contain three β sheets (N, C and A) and a central helical domain, similar to MTP from other species...
June 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28598687/lomitapide-for-the-treatment-of-hypercholesterolemia
#5
Amanda J Berberich, Robert A Hegele
Homozygous familial hypercholesterolemia (HoFH) is a serious rare inherited condition that leads to extremely elevated levels of low density lipoprotein cholesterol (LDL-C), and predisposes affected individuals to high risk of atherosclerotic vascular disease. Traditional therapies are largely ineffective in managing the hypercholesterolemia in these patients; diet and regular LDL-apheresis are the mainstays of management. Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP) that blocks the assembly of metabolic precursors of LDL particles...
June 9, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28597391/desorption-of-micropollutant-from-spent-carbon-filters-used-for-water-purifier
#6
Da-Sol Kwon, So-Yeon Tak, Jung-Eun Lee, Moon-Kyung Kim, Young Hwa Lee, Doo Won Han, Sanghyeon Kang, Kyung-Duk Zoh
In this study, to examine the accumulated micropollutants in the spent carbon filter used in the water purifier, first, the method to desorb micropollutant from the activated carbon was developed and optimized. Then, using this optimized desorption conditions, we examined which micropollutants exist in spent carbon filters collected from houses in different regions in Korea where water purifiers were used. A total of 11 micropollutants (caffeine (CFF), acetaminophen (ACT), sulfamethazine (SMA), sulfamethoxazole (SMZ), metoprolol (MTP), carbamazepine (CBM), naproxen (NPX), bisphenol-A (BPA), ibuprofen (IBU), diclofenac (DCF), and triclocarban (TCB)) were analyzed using LC/MS-MS from the spent carbon filters...
June 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28575566/-adaptation-to-intermittent-hypoxia-hyperoxia-improves-cognitive-performance-and-exercise-tolerance-in-elderly
#7
U Bayer, O S Glazachev, R Likar, M Burtscher, W Kofler, G Pinter, H Stettner, S Demschar, B Trummer, S Neuwersch
For improvements in exercise tolerance and cognitive function in geriatric patients Multimodal training programs (MTP) are used as combination of physiotherapy, occupational therapy and cardiovascular training. Intermittent Hypoxic-Hyperoxic Training (IHHT), a modified type of intermittent hypoxic training (IHT) is proposed to be included in MTP to elicit more pronounced beneficial effects in exercise tolerance and cognitive functions of geriatric patients likely by an additional pathway than a single MTP. Thirty four patients of the Geriatric Day Clinic aged between 64 and 92 years participated in the placebo controlled clinical trial...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28570126/second-and-third-metatarsophalangeal-plantar-plate-tears-diagnostic-performance-of-direct-and-indirect-mri-features-using-surgical-findings-as-the-reference-standard
#8
André Fukunishi Yamada, Michel D Crema, Caio Nery, Daniel Baumfeld, Tania Szejnfeld Mann, Abdalla Y Skaf, Artur da Rocha Correa Fernandes
OBJECTIVE: The objective of our study was to assess the diagnostic performance and associations of the direct and indirect MRI features of the metatarsophalangeal (MTP) joint that are thought to be related to tears of the plantar plate (PP) using surgical findings as the reference standard. MATERIALS AND METHODS: We retrospectively included 23 patients with symptomatic instability of lesser MTP joints who had undergone preoperative 1.5-T MRI and surgical assessment...
June 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28567339/hallux-rigidus-how-do-i-approach-it
#9
REVIEW
Aaron Lam, Jimmy J Chan, Michele F Surace, Ettore Vulcano
Hallux rigidus is a degenerative disease of the first metatarsalphalangeal (MTP) joint and affects 2.5% of people over age 50. Dorsal osteophytes and narrowed joint space leads to debilitating pain and limited range of motion. Altered gait mechanics often ensued as 119% of the body force transmit through the 1(st) MTP joint during gait cycle. Precise etiology remains under debate with trauma being often cited in the literature. Hallux valgus interphalangeus, female gender, inflammatory and metabolic conditions have all been identified as associative factors...
May 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28566782/early-results-of-an-intraosseous-device-for-arthrodesis-of-the-hallux-metatarsophalangeal-joint
#10
Efstathios Drampalos, Shen Hwa Vun, Levent Bayam, Irfan Fayyaz
BACKGROUND: Arthrodesis of the hallux metatarsophalangeal (MTP) joint is commonly done as a primary procedure either to correct severe hallux valgus deformities or for rheumatoid arthritis, hallux rigidus, in patients with neuromuscular disorders and as a salvage procedure for failed bunion surgery or infection. Prominent metalwork frequently can cause soft tissue impingement and thus require removal. In contrast, osteosynthesis with a completely intraosseous implant has the advantage of less damage to the periosteal circulation...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28551619/structure-activity-relationship-of-niclosamide-derivatives
#11
Zhonghai Tang, Ulyana Muñoz Acuña, Nelson Freitas Fernandes, Somsundaram Chettiar, Pui-Kai Li, Esperanza Carcache DE Blanco
BACKGROUND/AIM: Cancer is a leading cause of death. Hence, this study aimed at the optimization of niclosamide derivatives for the development of new potential anticancer agents. MATERIALS AND METHODS: Niclosamide derivatives were synthesized and tested against a panel of human cancer cells: MDA and MCF7 breast cancer cells, PC3 and DU-145 prostate cancer cells, Hela cervical cancer cells, and HL-60 acute promyelocytic leukemia cells. They were also tested in nuclear factor-ĸappa B (NFĸB), V-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), and mitochondria transmembrane potential (MTP) assays...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28550794/minimal-resection-interposition-arthroplasty-of-the-first-metatarsophalangeal-joint
#12
Panagiotis K Givissis, Panagiotis D Symeonidis, Dimitrios M Kitridis, Dimitrios N Daskalakis, Anastasios G Christodoulou
BACKGROUND: Interposition arthroplasty of the first metatarsophalangeal (MTP) joint is a viable alternative to fusion in patients with advanced hallux rigidus. The purpose of this study is to evaluate the midterm results of a modification of the technique. METHODS: Case series of 18 interposition arthroplasties were performed on 13 female patients with Grade III-IV hallux rigidus. The technique included cheilectomy, bunionectomy when needed, minimal resection of the base of the proximal phalanx and interposition of a fascia lata allograft in the first metatarsophalangeal joint...
March 23, 2017: Foot
https://www.readbyqxmd.com/read/28540517/development-of-microtiter-plate-culture-method-for-rapid-screening-of-%C3%AE%C2%B5-poly-l-lysine-producing-strains
#13
Yong-Juan Liu, Xu-Sheng Chen, Jun-Jie Zhao, Long Pan, Zhong-Gui Mao
ε-Poly-L-lysine (ε-PL) produced by Streptomyces albulus possesses a broad spectrum of antimicrobial activity and is widely used as a food preservative. To extensively screen ε-PL-overproducing strain, we developed an integrated high-throughput screening assay using ribosome engineering technology. The production protocol was scaled down to 24- and 48-deep-well microtiter plates (MTPs). The microplate reader assay was used to monitor ε-PL production. A good correlation was observed between the fermentation results obtained in both 24-(48)-deep-well MTPs and conventional Erlenmeyer flasks...
May 24, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28539973/are-ultrasound-features-at-the-first-metatarsophalangeal-joint-associated-with-clinically-assessed-pain-and-function-a-study-of-people-with-gout-asymptomatic-hyperuricaemia-and-normouricaemia
#14
Sarah Stewart, Nicola Dalbeth, Alain C Vandal, Bruce Allen, Rhian Miranda, Keith Rome
BACKGROUND: The first metatatarsophalangeal joint (1st MTP joint) is a common location for sonographic evidence of urate deposition in people with gout and asymptomatic hyperuricaemia. However, it is unclear whether these are related to clinically-assessed pain and function. This study aimed to determine the association between ultrasound features and clinical characteristics of the 1st MTP joint in people with gout, asymptomatic hyperuricaemia and age- and sex-matched normouricaemic individuals...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28535691/measuring-joint-flexibility-in-hallux-rigidus-using-a-novel-flexibility-jig
#15
Elizabeth A Cody, Andrew P Kraszewski, Anca Marinescu, Grace C Kunas, Sriniwasan B Mani, Smita Rao, Howard H Hillstrom, Scott J Ellis
BACKGROUND: The flexibility of the first metatarsophalangeal (MTP) joint in patients with hallux rigidus (HR) has not been studied. Compared to measuring range of motion alone, measures of joint flexibility provide additional information that may prove useful in the assessment of HR. The purpose of this study was to assess the flexibility of the hallux MTP joint in patients with HR compared to controls using a novel flexibility device. METHODS: Fifteen patients with Coughlin stage II or III HR and 20 healthy controls were recruited prospectively...
May 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28534270/occurrence-distribution-and-attenuation-of-pharmaceuticals-and-personal-care-products-in-the-riverside-groundwater-of-the-beiyun-river-of-beijing-china
#16
Lei Yang, Jiang-Tao He, Si-Hui Su, Ya-Feng Cui, De-Liang Huang, Guang-Cai Wang
This study investigated the occurrence, seasonal-spatial distribution characteristics, and attenuation process of 15 pharmaceuticals and personal care products (PPCPs) in riverside sections of Beiyun River of Beijing. The overall PPCP levels both in surface water and riverside groundwater were moderate on the global scale, and showed higher concentrations in the dry season mainly caused by water temperature variation. Caffeine (CF), carbamazepine (CBZ), metoprolol (MTP), N,N-diethyl-meta-toluamide (DEET), diclofenac (DF), bezafibrate (BF), and gemfibrozil (GF) were seven representative PPCPs, because the rest eight studied compounds occurred in low concentrations and less than 15% of the total concentration of PPCPs...
May 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28527425/effects-of-the-summer-holiday-season-on-uv-filter-and-illicit-drug-concentrations-in-the-korean-wastewater-system-and-aquatic-environment
#17
Ki Yong Kim, Kalu Ibe Ekpeghere, Hee-Jin Jeong, Jeong-Eun Oh
Seasonal variations in the concentrations of eight ultraviolet (UV) filters and 22 illicit drugs including their metabolites in the Korean aquatic environment were investigated. Seawater samples from three beaches, water samples from two rivers, and influents and effluents from three wastewater treatment plants were analyzed. The UV filter concentrations in the seawater, river water, and effluent samples were 39.4-296, 35.4-117, and 6.84-51.1 ng L(-1), respectively. The total UV filter concentrations in the seawater samples were 1...
August 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28527325/dyslipidemia-management-update
#18
REVIEW
Yingzi Chang, Jacques Robidoux
Association of hypercholesterolemia and atherosclerotic cardiovascular disease (ASCVD) is well established. Reducing low-density lipoprotein-cholesterol (LDL-C) and raising high-density lipoprotein-cholesterol (HDL-C) have been the therapeutic targets to reduce the risk of ASCVD. Cholesterol-lowering medications have been used to provide both primary and secondary prevention of ASCVD for many years by reducing the absorption and reabsorption, promoting excretion, or decreasing the synthesis of cholesterol. Within the past five years, several new classes of cholesterol-lowering drugs have been tested and approved for patients with hypercholesterolemia that are not well controlled by conventional therapy (ezetimibe, bile-acid sequestrants, and statins)...
April 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28520930/improved-power-for-tb-phase-iia-trials-using-a-model-based-pharmacokinetic-pharmacodynamic-approach-compared-with-commonly-used-analysis-methods
#19
Robin J Svensson, Stephen H Gillespie, Ulrika S H Simonsson
Background: The demand for new anti-TB drugs is high, but development programmes are long and costly. Consequently there is a need for new strategies capable of accelerating this process. Objectives: To explore the power to find statistically significant drug effects using a model-based pharmacokinetic-pharmacodynamic approach in comparison with the methods commonly used for analysing TB Phase IIa trials. Methods: Phase IIa studies of four hypothetical anti-TB drugs (labelled A, B, C and D), each with a different mechanism of action, were simulated using the multistate TB pharmacometric (MTP) model...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28515085/regulation-of-atp-production-dependences-on-calcium-concentration-and-respiratory-state
#20
Brian D Fink, Fan Bai, Liping Yu, William I Sivitz
Nanomolar free calcium enhances oxidative phosphorylation. However, the effects over a broad concentration range, at different respiratory states, or on specific energy substrates are less clear. We examined the action of varying [Ca(2+)] over respiratory states ranging 4 to 3 on skeletal muscle mitochondrial respiration, potential, ATP production, and H2O2 production using ADP recycling to clamp external [ADP]. 450 nM calcium enhanced respiration in mitochondria energized by the complex I substrates, glutamate/malate (but not succinate) at [ADP] of 4-256 µM, but more substantially at intermediate respiratory states and not all at state 4...
May 17, 2017: American Journal of Physiology. Cell Physiology
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