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https://www.readbyqxmd.com/read/28720138/plantar-plate-pathology-is-associated-with-erosive-disease-in-the-painful-forefoot-of-patients-with-rheumatoid-arthritis
#1
Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield, Philip S Helliwell
BACKGROUND: Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the metatarsophalangeal (MTP) joints are the most common site of symptoms. The plantar plates are the fibrocartilaginous distal attachments of the plantar fascia inserting into the five proximal phalanges. Together with the transverse metatarsal ligament they prevent splaying of the forefoot and subluxation of the MTP joints...
July 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28719428/blood-product-utilization-among-trauma-and-nontrauma-massive-transfusion-protocols-at-an-urban-academic-medical-center
#2
Eshan U Patel, Paul M Ness, Christi E Marshall, Thomas Gniadek, David T Efron, Peter M Miller, Joseph A Zeitouni, Karen E King, Evan M Bloch, Aaron A R Tobian
BACKGROUND: Hospital-wide massive transfusion protocols (MTPs) primarily designed for trauma patients may lead to excess blood products being prepared for nontrauma patients. This study characterized blood product utilization among distinct trauma and nontrauma MTPs at a large, urban academic medical center. METHODS: A retrospective study of blood product utilization was conducted in patients who required an MTP activation between January 2011 and December 2015 at an urban academic medical center...
July 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28714669/interconnected-hierarchical-zsm-5-with-tunable-acidity-prepared-by-a-dealumination-realumination-process-a-superior-mtp-catalyst
#3
Junjie Li, Min Liu, Xinwen Guo, Shutao Xu, Yingxu Wei, Zhongmin Liu, Chunshan Song
ZSM-5 that uses TPAOH as a template has an Al-rich exterior and defective Si-rich interior, thus it decouples the alkaline treatment difficulties of Al-rich and Si-rich crystals. Alkaline treatment selectively removed the Si-rich interior while the Al-rich exterior was protected, this catalyst showed no change in stability comparing with parent ZSM-5 during the MTP reaction that attributed to enclosed hollow structure and acidity-rich exterior. Pre-treatment by NH4F, however, both removed defective Si-sites and caused distortion in tetrahedral aluminum that made the outer shell susceptible to alkaline treatment...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28714106/prevalence-and-distribution-of-sesamoid-bones-and-accessory-ossicles-of-the-foot-as-determined-by-digital-tomosynthesis
#4
Bon San Koo, Yoonah Song, Seunghun Lee, Yoon-Kyoung Sung, Il-Hoon Sung, Jae-Bum Jun
We previously reported that digital tomosynthesis (DTS) is a reliable tool for evaluating bony structures of the hand. The current study aimed to identify the prevalence and distribution of sesamoid bones and accessory ossicles of the foot using DTS and to compare the results to those of conventional radiography (CR). Foot images (DTS, 213; CR, 44) of 213 patients taken at a tertiary hospital were retrospectively reviewed. Sesamoid bones were identified in the metatarsaophalangeal (MTP), distal interphalangeal (DIP) and interphalangeal (IP) joints of the great (I), second (II), third (III), fourth (IV), and fifth (V) toes...
July 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28702990/the-relationship-of-amphipathic-beta-structures-in-the-beta-1-domain-of-apolipoprotein-b-to-the-properties-of-the-secreted-lipoprotein-particles-in-mca-rh7777-cells
#5
Medha Manchekar, Richa Kapil, Zhihuan Sun, Jere P Segrest, Nassrin Dashti
Our previous studies demonstrated that the first 1000 amino acid residues (the βα1 domain) of human apolipoprotein (apo) B-100, referred to as apoB:1000, are required for the initiation of lipoprotein assembly and the formation of a monodisperse stable phospholipid (PL)-rich particle. The objectives of this study were to: a) assess the effects on the properties of apoB truncates undergoing sequential inclusion of the amphipathic β strands in the N-terminal 700 residues of the β1 domain of apoB-100, and b) identify the subdomain in the β1 domain that is required for the formation of a microsomal triglyceride transfer protein (MTP)-dependent triacylglycerol (TAG)-rich apoB-containing particle...
July 13, 2017: Biochemistry
https://www.readbyqxmd.com/read/28696376/lack-of-additive-effects-of-resveratrol-and-energy-restriction-in-the-treatment-of-hepatic-steatosis-in-rats
#6
Iñaki Milton-Laskibar, Leixuri Aguirre, Alfredo Fernández-Quintela, Anabela P Rolo, João Soeiro Teodoro, Carlos M Palmeira, María P Portillo
The aims of the present study were to analyze the effect of resveratrol on liver steatosis in obese rats, to compare the effects induced by resveratrol and energy restriction and to research potential additive effects. Rats were initially fed a high-fat high-sucrose diet for six weeks and then allocated in four experimental groups fed a standard diet: a control group, a resveratrol-treated group, an energy restricted group and a group submitted to energy restriction and treated with resveratrol. We measured liver triacylglycerols, transaminases, FAS, MTP, CPT1a, CS, COX, SDH and ATP synthase activities, FATP2/FATP5, DGAT2, PPARα, SIRT1, UCP2 protein expressions, ACC and AMPK phosphorylation and PGC1α deacetylation...
July 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28694515/physical-binding-of-endothelial-mcam-and-neural-transmembrane-protease-matriptase-novel-cell-adhesion-in-neural-stem-cell-vascular-niche
#7
Hsiu-Hui Tung, Sheau-Ling Lee
Brain neural stem cells and transit amplifying cells in the subventricular zone (SVZ) of the lateral ventricles are in direct contact with the microvascular endothelium. The mechanisms/molecules of direct cell contact in the SVZ neurovascular niche are not fully understood. We previously showed that neural stem/progenitor (NS/P) cells induce brain endothelial signaling in direct cell contact through matriptase (MTP) on NS/P cell surface. In the present study, using pull-down and LC-MS/MS, we identified melanoma cell adhesion molecule (MCAM) the brain endothelial molecule that interacts with MTP...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28688890/any-changes-in-recent-massive-transfusion-practices-in-a-tertiary-level-institution
#8
Romi Sinha, David Roxby
BACKGROUND & OBJECTIVES: A previous review of transfusion practices in our institution between 1998 and 2008 showed a trend of high ratios of red cells (RC) to plasma (FFP) and platelets to RC towards the later years of review period. The aim of the study was to further evaluate transfusion practices in the form of blood product usage and outcomes following massive transfusion (MT) METHODS: All adult patients with critical bleeding who received a MT (defined as ≥10 units of RC in 24h) in 2008 and between January 2010 and December 2014 were identified...
June 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28686846/effect-of-first-tarsometatarsal-joint-derotational-arthrodesis-on-first-ray-dynamic-stability-compared-to-distal-chevron-osteotomy
#9
Tero Klemola, Juhana Leppilahti, Vesa Laine, Ilkka Pentikäinen, Risto Ojala, Pasi Ohtonen, Olli Savola
BACKGROUND: Hallux valgus alters gait, compromising first ray stability and function of the windlass mechanism at the late stance. Hallux valgus correction should restore the stability of the first metatarsal. Comparative studies reporting the impact of different hallux valgus correction methods on gait are rare. We report the results of a case-control study between distal chevron osteotomy and first tarsometatarsal joint derotational arthrodesis (FTJDA). METHODS: Two previously studied hallux valgus cohorts were matched: distal chevron osteotomy and FTJDA...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28685493/peripheral-neuropathy-episodic-rhabdomyolysis-and-hypoparathyroidism-in-a-patient-with-mitochondrial-trifunctional-protein-deficiency
#10
Peter van Vliet, Annelies E Berden, Mojca K M van Schie, Jaap A Bakker, Christian Heringhaus, Irenaeus F M de Coo, Mirjam Langeveld, Marielle A Schroijen, M Sesmu Arbous
A combination of unexplained peripheral neuropathy, hypoparathyroidism, and the inability to cope with metabolic stress could point to a rare inborn error of metabolism, such as mitochondrial trifunctional protein (MTP) deficiency.Here, we describe a 20-year-old woman who was known since childhood with axonal motor sensory polyneuropathy of unknown origin. She presented with progressive dyspnoea, and increased muscle weakness, preceded by 6 days of fever, vomiting, and diarrhoea. Laboratory testing showed rhabdomyolysis, and hypocalcaemia with low parathyroid levels...
July 7, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28676916/-correction-of-flexible-lesser-toe-deformity-transfer-of-the-flexor-digitorum-longus-tendon
#11
D Arbab, D Frank, B Bouillon, C Lüring
OBJECTIVE: Realignment and pain relief of toes 2-5 by flexor-to-extensor tendon transfer of the flexor digitorum longus (FDL) muscle. INDICATIONS: As an isolated procedure in flexible proximal interphalangeal (PIP) joint flexion and/or flexible metatarsophalangeal (MTP) joint extension (hammer toe). In combination with a metatarsal osteotomy or PIP joint arthrodesis in case of flexible MTP joint extension. CONTRAINDICATIONS: General medical contraindications to surgical interventions...
July 4, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28665508/a-polymorphism-in-the-cyp17a1-gene-influences-the-therapeutic-response-to-steroidogenesis-inhibitors-in-cushing-s-syndrome
#12
Elena Valassi, Anna Aulinas, Camilla Am Glad, Gudmundur Johannsson, Oskar Ragnarsson, Susan M Webb
CONTEXT: Steroidogenesis inhibitors, such as ketoconazole (KTZ) and metyrapone (MTP) are used to lower hypercortisolism in patients with Cushing's syndrome (CS). Cortisol normalization is not reached in all patients taking these medications. OBJECTIVE: To test the hypothesis that variants in genes affecting steroidogenesis contribute to different responses to KTZ and/or MTP in patients with CS. PATIENTS AND METHODS: Fifty-four CS patients [46 women; mean (±SD) age, 39...
June 30, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28663020/treatment-of-end-stage-hallux-rigidus-using-total-joint-arthroplasty-a-short-term-clinical-study
#13
Turan Cihan Dülgeroğlu, Hasan Metineren
The treatment of advanced hallux rigidus remains controversial. Only a few studies have analyzed the short- and mid-term results of metatarsophalangeal (MTP) joint arthroplasty to treat patients with advanced hallux rigidus. We present the short-term follow-up results of patients who underwent MTP joint arthroplasty. We reviewed the medical records of 15 consecutive patients (3 males and 12 females) who had had grade 3 or 4 hallux rigidus diagnosed according to the Coughlin and Shurnas classification. The age range at surgery was 44 to 74 (mean 61...
June 26, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28657202/assessing-pharmacodynamic-interactions-in-mice-using-the-multistate-tuberculosis-pharmacometric-and-general-pharmacodynamic-interaction-models
#14
Chunli Chen, Sebastian G Wicha, Gerjo J de Knegt, Fatima Ortega, Laura Alameda, Veronica Sousa, Jurriaan E M de Steenwinkel, Ulrika S H Simonsson
The aim of this study was to investigate pharmacodynamic interactions in mice infected with Mycobacterium tuberculosis using population pharmacokinetics, the Multistate Tuberculosis Pharmacometric (MTP) model, and the General Pharmacodynamic Interaction (GPDI) model. Rifampicin, isoniazid, ethambutol or pyrazinamide were administered in monotherapy for 4 weeks. Rifampicin and isoniazid showed effects in monotherapy, whereas the animals became moribund after 7 days with ethambutol or pyrazinamide alone. No pharmacodynamic interactions were observed against fast-multiplying bacteria...
June 28, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28637481/arthroscopic-treatment-of-focal-osteochondral-lesions-of-the-first-metatarsophalangeal-joint
#15
Ersin Kuyucu, Harun Mutlu, Serhat Mutlu, Baris Gülenç, Mehmet Erdil
BACKGROUND: Although arthroscopic surgical treatment of the first metatarsophalangeal (MTP) joint involves painful sesamoid excision, synovectomy, debridement, and partial cheilectomy, no gold standard treatment technique has been defined in the literature for hallux rigidus and focal osteochondral lesions. This study aimed to assess the arthroscopic treatment for early-grade focal osteochondral lesions of the first MTP joint and to determine the impact of arthroscopic microhole drill surgery on foot function and activities of daily living in a group of patients who failed conservative treatment...
June 21, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28620733/management-of-congenital-diaphragmatic-hernia-in-newborn-paradigm-shift-and-ethical-issues
#16
Sushmita Nitin Bhatnagar, Yogesh Kumar Sarin
Management of congenital diaphragmatic hernia (CDH) begins soon after it is detected, whether antenatally or postnatally. Assessment of the severity of the condition, associated congenital anomalies, maternal health and related issues, weight of the fetus/baby, mode of delivery, timing of delivery, immediate appropriate management of the baby with CDH at birth, appropriate utilization of available treatment modalities as well as infrastructure of the treating institute have an impact on the outcome of the neonate...
August 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28608725/driving-after-hallux-valgus-surgery
#17
Elizabeth McDonald, Rachel Shakked, Joseph Daniel, David I Pedowitz, Brian S Winters, Christopher Reb, Mary-Katherine Lynch, Steven M Raikin
BACKGROUND: The purpose of the study was to determine when patients can safely return to driving after first metatarsal osteotomy for hallux valgus correction. METHODS: After institutional review board approval, 60 patients undergoing right first metatarsal osteotomy for hallux valgus correction surgery were recruited prospectively. Patients' brake reaction time (BRT) was tested at 6 weeks and repeated until patients achieved a passing BRT. A control group of twenty healthy patients was used to establish as passing BRT...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28607766/hallux-rigidus
#18
REVIEW
Bryant Ho, Judith Baumhauer
An estimated 40% of the US population have foot problems.Of all patients aged over 50 years, 2.5% report degenerative arthritis of the first metatarsophalangeal (MTP) joint, termed 'hallux rigidus'. First MTP osteoarthritis is the most common arthritic condition in the foot.Progression of great toe arthritis is associated with pain and loss of motion. Non-surgical intervention begins with shoe modifications and orthotics designed to limit MTP motion.In patients with mild arthritis, operative procedures focus on removing excess osteophytes (cheilectomy) to prevent dorsal impingement with or without a concomitant osteotomy (Moberg) to improve or shift range of motion into a less painful arc...
January 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28601811/microsomal-triglyceride-transfer-protein-mtp-in-the-ectoparasitic-crustacean-salmon-louse-l-salmonis
#19
Muhammad Tanveer Khan, Sussie Dalvin, Frank Nilsen, Rune Male
The salmon louse Lepeophtheirus salmonis is a challenging ectoparasite for the salmon farming industry and wild salmonids. Salmon lice have a very high reproductive output, that require deposition of large amounts of lipids into growing oocytes as a major energy source, most probably mediated by lipoproteins. Microsomal triglyceride transfer protein (MTP) is essential for the assembly of lipoproteins. Salmon lice have three LsMTP transcript variants encoding two different protein isoforms predicted to contain three β sheets (N, C and A) and a central helical domain, similar to MTP from other species...
June 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28598687/lomitapide-for-the-treatment-of-hypercholesterolemia
#20
Amanda J Berberich, Robert A Hegele
Homozygous familial hypercholesterolemia (HoFH) is a serious rare inherited condition that leads to extremely elevated levels of low density lipoprotein cholesterol (LDL-C), and predisposes affected individuals to high risk of atherosclerotic vascular disease. Traditional therapies are largely ineffective in managing the hypercholesterolemia in these patients; diet and regular LDL-apheresis are the mainstays of management. Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP) that blocks the assembly of metabolic precursors of LDL particles...
June 9, 2017: Expert Opinion on Pharmacotherapy
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