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https://www.readbyqxmd.com/read/29908457/sleep-disorders-among-yusho-patients-highly-intoxicated-with-dioxin-related-compounds-a-140-case-series
#1
Hideaki Kondo, Keiko Tanio, Yuki Nagaura, Mako Nagayoshi, Chikage Mitoma, Masutaka Furue, Takahiro Maeda
PURPOSE: Patients with Yusho, a condition caused by exposure to dioxins and dioxin-like compounds, have diverse mental and physical complaints. However, the relationship between dioxins and sleep disorders has not yet been examined. This cross-sectional study was designed to investigate problems associated with sleep among patients with Yusho. METHODS: A total of 140 participants (52.9% men, average age: 67.1 ± 12.2 years) were examined using questionnaires and medical interviews by an expert on sleep medicine...
June 13, 2018: Environmental Research
https://www.readbyqxmd.com/read/29908352/man1b-cdg-novel-variants-with-a-distinct-phenotype-and-review-of-literature
#2
Meena Balasubramanian, Diana S Johnson
BACKGROUND: Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases due to impaired lipid and protein glycosylation. It comprises a characteristic high frequency of intellectual disability (ID) and a wide range of clinical phenotypes. OBJECTIVE: (s): To identify the underlying diagnosis in two families each with two siblings with variable level of ID through trio whole exome sequencing. METHODS: Both the families were recruited to the Deciphering Developmental Disorders (DDD) study to identify the aetiology for their ID...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908300/acute-and-chronic-escitalopram-alter-eeg-gamma-oscillations-differently-relevance-to-therapeutic-effects
#3
Noémi Papp, Szilvia Vas, Emese Bogáthy, Zita Kátai, Diána Kostyalik, György Bagdy
Brain oscillations in the gamma frequency band of the electroencephalogram (EEG) have been implicated in several sensory and cognitive processes, and have also been associated with numerous neuropsychiatric disorders, including depression. The widely prescribed selective serotonin reuptake inhibitors (SSRIs), similarly to other antidepressants, are known to produce markedly different effects on sleep and behavioral measures with acute and chronic administration. Although there are studies examining the acute effect of escitalopram on slower (<30 Hz) oscillations, we hardly could find any data about the effect of the drug on higher-frequency EEG oscillations (>30 Hz) in different sleep-wake stages, particularly comparing the acute and chronic effects of the drug concerning gamma oscillations...
June 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29908105/phase-ii-trial-of-biweekly-cetuximab-and-irinotecan-as-third-line-therapy-for-pretreated-kras-exon-2-wild-type-colorectal-cancer
#4
Hiroki Osumi, Eiji Shinozaki, Tetsuo Mashima, Takeru Wakatsuki, Mitsukuni Suenaga, Takashi Ichimura, Mariko Ogura, Yumiko Ota, Izuma Nakayama, Daisuke Takahari, Keisho Chin, Yoshio Miki, Kensei Yamaguchi
Efficacy and safety of biweekly cetuximab plus irinotecan were evaluated to provide guidance for its use in Japan as third-line treatment for pretreated metastatic colorectal cancer patients harboring wild-type KRAS Exon 2. Objective response rate was used as primary endpoint based on an expected proportion of 0.23 with confidence width of 0.298 (95% confidence interval, 0.105-0.403), which showed 35 to be the minimal participant number. Forty patients, refractory to first- and second-line chemotherapy containing irinotecan, oxaliplatin, and fluoropyrimidine were enrolled...
June 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29908047/can-surgical-reconstruction-of-vaginal-and-ligamentous-laxity-cure-over-active-bladder-symptoms-in-women-with-pelvic-organ-prolapse
#5
Bernhard Liedl, Klaus Goeschen, Suzette E Sutherland, Jean-Paul Roovers, Alexander Yassouridis
OBJECTIVE: The objective of this interventional study was to examine extent and intensity of the coexistence of overactive bladder (OAB) symptoms in women with pelvic organ prolapse (POP) and to evaluate the likelihood of OAB symptom improvement after surgical POP reconstruction in a period of two years. PATIENTS AND METHODS: The effectiveness of the transvaginal, single-incision Elevate@ technique for anatomical cure of anterior/apical and posterior/apical vaginal prolapse has been previously reported following a prospective, multicenter study...
June 16, 2018: BJU International
https://www.readbyqxmd.com/read/29908012/allelic-and-haplotype-diversity-of-hla-a-hla-b-and-hla-drb1-gene-at-high-resolution-in-the-nanning-han-population
#6
YongFeng Pei, HuiNi Huang, HengCong Li, JieRun Chen, GuoGuang Wu
The distribution of human leucocyte antigen (HLA) allele and haplotype varied among different ethnic populations. In this study, we investigated the allele and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 loci in the Nanning Han population who live in Guangxi province of China. We identified 26 HLA-A, 56 HLA-B and 31 HLA-DRB1 alleles in 562 Nanning individuals of Han ethnic group by sequence-based typing method. Of these, the three most common alleles in HLA-A, HLA-B and HLA-DRB1 loci, respectively, were A*11:01 (32...
June 15, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29908002/shielding-a-high-sensitivity-digital-detector-from-electromagnetic-interference
#7
David E Hintenlang, Xia Jiang, Kevin J Little
PURPOSE: To document a study in shielding a high-sensitivity digital mammography system detector from AC magnetic fields of magnitudes great enough to induce imaging artifacts. METHODS/MATERIALS: Preliminary evaluation of AC magnetic fields at a site designated for a digital breast tomosynthesis (DBT) system raised concerns that the magnetic component of electromagnetic interference (EMI) may be great enough to induce imaging artifacts. Subsequent measurements using digital detector arrays from two separate manufacturers verified this concern, and AC magnetic fields were mapped, spatially and temporally, throughout the area of concern...
June 15, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29907958/the-mechanosensory-motor-apparatus-of-antennae-in-the-oleander-hawk-moth-daphnis-nerii-lepidoptera
#8
Harshada H Sant, Sanjay P Sane
Insect antennae are sensory organs of great importance because they can sense diverse environmental stimuli. In addition to serving as primary olfactory organs of insects, antennae also sense a wide variety of mechanosensory stimuli, ranging from low-frequency airflow or gravity cues to high-frequency antennal vibrations due to sound, flight or touch. The basal segments of the antennae house multiple types of mechanosensory structures that prominently include the sensory hair plates, or Böhm's bristles, which measure the gross extent of antennal movement, and a ring of highly sensitive scolopidial neurons, collectively called the Johnston's organs, which record subtle flagellar vibrations...
June 15, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29907902/an-environmental-surveillance-in-uruguay-reveals-the-presence-of-highly-divergent-types-of-human-enterovirus-species-c-and-a-high-frequency-of-species-a-and-b-types
#9
Andrés Lizasoain, Fernanda M Burlandy, Matías Victoria, Luis F López Tort, Edson E da Silva, Rodney Colina
Information about Human Enterovirus circulation in Uruguay is scarce. The aim of this study was to generate the first description about their circulation in the country through the study of sewage samples collected before and after the switch from Oral Poliovirus Vaccine to Inactivated Poliovirus Vaccine. Viruses were concentrated by an adsorption-elution to a negatively charged membrane, and real-time quantitative PCR and qualitative PCR methods were used to detect, quantify, and characterize enteroviruses...
June 16, 2018: Food and Environmental Virology
https://www.readbyqxmd.com/read/29907885/recognition-and-control-of-hypertension-diabetes-and-dyslipidemia-in-patients-with-rheumatoid-arthritis
#10
Luísa Lima Castro, Cristina Costa Duarte Lanna, Mariana Pimenta Rocha, Antônio Luiz Pinho Ribeiro, Rosa Weiss Telles
Absolute cardiovascular risk of an individual with rheumatoid arthritis (RA) is greater when compared to the general population, and several factors have proven to be important for the development of coronary artery disease (CAD) in these patients, including factors related to the underlying disease, such as the systemic inflammatory response, drugs used in its treatment, and a higher prevalence of traditional risk factors for CAD. Our aim is to describe the recognition and control frequencies of systemic arterial hypertension (SAH), dyslipidemia, and diabetes mellitus (DM) in RA patients...
June 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29907858/broadband-frequency-reconfigurable-metamaterial-absorber-using-switchable-ground-plane
#11
Heijun Jeong, Sungjoon Lim
In this study, we propose a broadband frequency-reconfigurable metamaterial absorber using a novel switchable ground plane (SGP). A double resistive square-ring resonator is introduced for broadband absorption. The distance between the top resonator pattern and the ground plane determines the resonant frequency; the proposed SGP is thus capable of switching the absorption frequency band. The SGP can be either ground or reactive, by switching the PIN diodes on and off, respectively. The SGP is placed as the middle layer, between the top pattern and the bottom ground plane...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907801/comparative-assessment-of-gene-specific-variant-distribution-in-prenatal-and-postnatal-cohorts-tested-for-noonan-syndrome-and-related-conditions
#12
N L Leach, D R Wilson Mathews, L S Rosenblum, Z Zhou, H Zhu, R A Heim
PURPOSE: To compare the pattern of gene-specific involvement and the spectrum of variants observed in prenatal and postnatal (mean ± SD, 8.9 ± 9.4 years) cohorts tested for Noonan syndrome and related conditions. METHODS: Outcomes of sequencing panel testing were compared between prenatal (n = 845) and postnatal (n = 409) cohorts. RESULTS: PTPN11 and SOS1 harbored the majority of observed variants in both prenatal and postnatal cohorts, and BRAF, HRAS, KRAS, MAP2K1, MAP2K2, RAF1, and SHOC2 had similarities in their pattern of involvement in both cohorts...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29907772/investigation-of-return-photons-from-sodium-laser-beacon-excited-by-a-40-watt-facility-class-pulsed-laser-for-adaptive-optical-telescope-applications
#13
Qi Bian, Yong Bo, Junwei Zuo, Min Li, Ruoxi Dong, Keran Deng, Dingwen Zhang, Liping He, Qingshuang Zong, Dafu Cui, Qinjun Peng, Hongbin Chen, Zuyan Xu
The brightness of the artificial beacon is one critical performance parameter for adaptive optics. Here, a 40-watt level narrow-linewidth microsecond pulsed yellow laser is produced at 589 nm with a high repetition frequency of 600 Hz and a pulse duration of 120 μs. An experiment to project the pulse beam up to the sky and measure the fluorescence photon returns of the Na atoms has been held on the 1.8-meter telescope in Lijiang observatory. During the sky test, a laser guide star (LGS) spot is firstly observed with Rayleigh scattering elimination by means of a gateable pulse format...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907759/bisphenol-a-exposure-during-early-pregnancy-impairs-uterine-spiral-artery-remodeling-and-provokes-intrauterine-growth-restriction-in-mice
#14
Judith Elisabeth Müller, Nicole Meyer, Clarisa Guillermina Santamaria, Anne Schumacher, Enrique Hugo Luque, Maria Laura Zenclussen, Horacio Adolfo Rodriguez, Ana Claudia Zenclussen
Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways. No studies dissected its short-term effects on pregnancy and possible underlying mechanisms. Here, we studied how BPA exposure around implantation affects pregnancy, particularly concentrating on placentation and uterine remodeling. We exposed pregnant female mice to 50 µg/kg BPA/day or 0.1% ethanol by oral gavage from day 1 to 7 of gestation...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907599/aggressive-b-cell-lymphomas-in-patients-with-myelofibrosis-receiving-jak1-2-inhibitor-therapy
#15
Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gregor Hoermann, Jean-Jacques Kiladjian, Thomas Kolbe, Christoph Kornauth, Maria-Theresa Krauth, Robert Kralovics, Leonhard Muellauer, Mathias Mueller, Michaela Prchal-Murphy, Eva Maria Putz, Emmanuel Raffoux, Ana-Iris Schiefer, Klaus Schmetterer, Christine Schneckenleithner, Ingrid Simonitsch-Klupp, Cathrin Skrabs, Wolfgang R Sperr, Philipp Bernhard Staber, Birgit Strobl, Peter Valent, Ulrich Jaeger, Heinz Gisslinger, Veronika Sexl
Inhibition of Janus-kinase 1/2 (JAK1/2) is a mainstay to treat myeloproliferative neoplasms (MPN). Sporadic observations reported the co-incidence of B-cell non-Hodgkin lymphomas during treatment of MPN with JAK1/2 inhibitors. We assessed 626 MPN patients including 69 with myelofibrosis receiving JAK1/2 inhibitors for lymphoma development. B-cell lymphomas evolved in 4/69 patients (5.8%) upon JAK1/2 inhibition compared to 2/557 (0.36%) with conventional treatment (16-fold increased risk). A similar 15-fold increase was observed in an independent cohort of 929 MPN patients...
June 14, 2018: Blood
https://www.readbyqxmd.com/read/29907544/impact-of-flt3-receptor-cd135-detection-by-flow-cytometry-on-clinical-outcome-of-adult-acute-myeloid-leukemia-patients
#16
Eman Z Kandeel, Ghada El Sayed, Nahla Elsharkawy, Dalia Negm Eldin, Hanan R Nassar, Dalia Ibrahiem, Randa Amin, Marwa Hanafi, Mohamed Khalil, Azza Kamel
BACKGROUND: The significance of FMS-like tyrosine kinase 3 (FLT3)-ITD mutation in acute myeloid leukemia (AML) prognosis has been well established. The aims of this study were to investigate the prognostic impact of the FLT3 protein (CD135) expression and its association with FLT3-ITD mutation, and to identify its role in minimal residual disease. PATIENTS AND METHODS: CD135 was measured by flow cytometry on leukemic blasts of 257 adults with de novo AML. High expression of CD135 ≥ 20% was correlated with clinical, laboratory, and other prognostic factors that influenced treatment outcome...
May 26, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29907494/what-prevents-youth-at-clinical-high-risk-for-psychosis-from-engaging-in-physical-activity-an-examination-of-the-barriers-to-physical-activity
#17
Raeana E Newberry, Derek J Dean, Madison D Sayyah, Vijay A Mittal
BACKGROUND: Exercise has increasingly been proposed as a healthful intervention prior to and after the onset of psychosis. There is some evidence to suggest that youth at clinical high risk (CHR) for psychosis are less physically active and report more barriers to engaging in exercise; however, there has been relatively limited empirical work documenting this phenomenon, and to date, relationships between physical activity, barriers, and clinical phenomenology have been unclear. METHODS: CHR (N = 51) and healthy control (N = 37) participants completed a structured clinical interview assessing attenuated psychotic symptoms and substance use, and an exercise survey that assessed current exercise practices, perceived physical fitness, and barriers related to engaging in exercise...
June 13, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29907477/successful-treatment-of-normokalemic-periodic-paralysis-with-hydrochlorothiazide
#18
Yuichi Akaba, Satoru Takahashi, Yoshiaki Sasaki, Hiroki Kajino
BACKGROUND: Periodic paralysis (PP) is an autosomal dominant muscle disorder characterized by periodic muscle weakness attacks associated with serum potassium level variations. It is classified into hypokalemic (hypoKPP), hyperkalemic (hyperKPP), and normokalemic (normoKPP) forms based on the ictal serum potassium level. HyperKPP and normoKPP are caused by mutations of the same gene SCN4A, the gene encoding the skeletal muscle voltage-gated sodium channel. Prophylactic treatment with thiazide diuretics is highly effective in preventing attacks in hyperKPP...
June 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29907439/distribution-of-biocide-resistant-genes-and-biocides-susceptibility-in-multidrug-resistant-klebsiella-pneumoniae-pseudomonas-aeruginosa-and-acinetobacter-baumannii-a-first-report-from-the-kingdom-of-saudi-arabia
#19
Rajendran Vijayakumar, Tim Sandle, Mohammad Saleh Al-Aboody, Meshal K AlFonaisan, Wael Alturaiki, Suresh Mickymaray, Mariappan Premanathan, Suliman A Alsagaby
PURPOSES: The aim of this study was to determine the frequency of biocide resistant genes, qacA, qacE and cepA in multidrug resistant (MDR) bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii and to correlate the presence or absence of resistant genes with biocides susceptibility. MATERIALS AND METHODS: The study included 44 MDR K. pneumoniae, P. aeruginosa and A. baumannii microorganisms. The bacteria were screened for the presence of biocide resistant genes by the polymerase chain reaction (PCR) method...
June 12, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29907109/epidemiological-trends-and-risk-factors-associated-with-dengue-disease-in-pakistan-1980-2014-a-systematic-literature-search-and-analysis
#20
Jehangir Khan, Inamullah Khan, Abdul Ghaffar, Bushra Khalid
BACKGROUND: Dengue is becoming more common in Pakistan with its alarming spreading rate. A historical review needs to be carried out to find the root causes of dengue dynamics, the factors responsible for its spread and lastly to formulate future strategies for its control. METHODS: We searched (January, 2015) all the published literature between 1980 and 2014 to determine spread/burden of dengue disease in Pakistan. RESULTS: A total of 81 reports were identified, showing high numbers of dengue cases in 2010, 2011, and 2013...
June 15, 2018: BMC Public Health
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