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https://www.readbyqxmd.com/read/28211089/icariin-promotes-mouse-hair-follicle-growth-by-increasing-insulin-like-growth-factor-1-expression-in-dermal-papillary-cells
#1
Y-S Su, Z-X Fan, S-E Xiao, B-J Lin, Y Miao, Z-Q Hu, H Liu
BACKGROUND: Icariin is a major flavonoid isolated from Epimedium spp. leaves (Epimedium Herba), and has multiple pharmacological functions, including anti-angiogenesis, anti-oxidant, anti-inflammatory and immunoprotective effects. AIM: To investigate whether icariin can stimulate growth of hair follicles in mice and the underlying mechanism. METHODS: In vitro, the effect of icariin on hair growth was assessed by using a vibrissae hair follicle (VHF) organ-culture model...
February 16, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28205242/one-way-or-another-iron-uptake-in-plants
#2
Huei-Hsuan Tsai, Wolfgang Schmidt
Iron (Fe) and phosphorus (P), the latter taken up by plants as phosphate (Pi), are two essential nutrients that determine species distribution and often limit crop yield as a result of their low availability in most soils. Pi-deficient plants improve the interception of Pi by increasing the density of root hairs, thereby expanding the volume of soil to be explored. The increase in root hair frequency results mainly from attenuated primary root growth, a process that was shown to be dependent on the availability of external Fe...
February 16, 2017: New Phytologist
https://www.readbyqxmd.com/read/28203334/assessment-of-sexual-maturation-among-girls-with-special-needs-in-tehran-iran
#3
Hosein Shabani Mirzaee, Asieh Mosallanejad, Ali Rabbani, Aria Setoodeh, Farzaneh Abbasi, Fatemeh Sayarifard, Amir Hosein Memari
BACKGROUND: There is limited data on sexual maturation among girls with intellectual, sensory, or physical disabilities. OBJECTIVES: The present cross-sectional study was conducted to assess the sexual maturation of girls with these disabilities in special schools. METHODS: In this cross-sectional study, we evaluated the onset and progression of sexual maturation in 642 six to 18-year-old girls with intellectual, sensory, or physical disabilities from special schools in Tehran...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28202726/two-tonoplast-mate-proteins-function-as-turgor-regulating-chloride-channels-in-arabidopsis
#4
Haiwen Zhang, Fu-Geng Zhao, Ren-Jie Tang, Yuexuan Yu, Jiali Song, Yuan Wang, Legong Li, Sheng Luan
The central vacuole in a plant cell occupies the majority of the cellular volume and plays a key role in turgor regulation. The vacuolar membrane (tonoplast) contains a large number of transporters that mediate fluxes of solutes and water, thereby adjusting cell turgor in response to developmental and environmental signals. We report that two tonoplast Detoxification efflux carrier (DTX)/Multidrug and Toxic Compound Extrusion (MATE) transporters, DTX33 and DTX35, function as chloride channels essential for turgor regulation in Arabidopsis Ectopic expression of each transporter in Nicotiana benthamiana mesophyll cells elicited a large voltage-dependent inward chloride current across the tonoplast, showing that DTX33 and DTX35 each constitute a functional channel...
February 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28197104/angled-growth-of-the-dental-lamina-is-accompanied-by-asymmetrical-expression-of-the-wnt-pathway-receptor-frizzled-6
#5
Iveta Putnová, Hana Dosedělová, Vitezslav Bryja, Marie Landová, Marcela Buchtová, Jan Štembírek
Frizzled 6 (FZD6) belongs to a family of proteins that serve as receptors in the WNT signaling pathway. FZD6 plays an important role in the establishment of planar cell polarity in many embryonic processes such as convergent extension during gastrulation, neural tube closure, or hair patterning. Based on its role during hair development, we hypothesized that FZD6 may have similar expression pattern and function in the dental lamina, which is also a distinct epithelial protrusion growing characteristically angled into the mesenchyme...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28193226/hair-growth-promoting-effect-of-geranium-sibiricum-extract-in-human-dermal-papilla-cells-and-c57bl-6-mice
#6
William A Boisvert, Miri Yu, Youngbin Choi, Gi Hee Jeong, Yi-Lin Zhang, Sunghun Cho, Changsun Choi, Sanghyun Lee, Bog-Hieu Lee
BACKGROUND: Geranium sibiricum L. has been used as a medicinal plant to treat diarrhea, bacterial infection, and cancer in Bulgaria, Peru, and Korea. However, its hair growth-promoting effect was not investigated so far. This study examined the effects of Geranium sibiricum L. extract (GSE) on hair growth, using in vitro and in vivo models. METHODS: Antioxidant, proliferation and migration assay of GSE was performed with human dermal papilla cells (hDPCs). Hair-growth promoting effect was measured in animal model...
February 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28190468/curcuma-aeruginosa-roxb-essential-oil-slows-hair-growth-and-lightens-skin-in-axillae-a-randomised-double-blinded-trial
#7
Jukkarin Srivilai, Preeyawass Phimnuan, Jiraporn Jaisabai, Nantakarn Luangtoomma, Neti Waranuch, Nantaka Khorana, Wudtichai Wisuitiprot, C Norman Scholfield, Katechan Champachaisri, Kornkanok Ingkaninan
BACKGROUND: Androgenic hair-growth contributes to secondary gender characteristics but can be troublesome in women. Inhibiting axillary hair-growth via 5-α-reductases using the Thai medicinal plant, Curcuma aeruginosa Roxb. is an attractive treatment strategy. HYPOTHESIS/PURPOSE: C. aeruginosa essential oil (CA-oil) formulated as a lotion is an efficacious and safe inhibitor of axillary hair growth. STUDY DESIGN: This trial was a single center, randomized, double-blind, placebo controlled 10 weeks, intervention in 60 women (18-23 years) and 2 weeks washout with axillary hair length was the primary end-point...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28188805/sphingosine-1-phosphate-signaling-axis-mediates-fibroblast-growth-factor-2-induced-proliferation-and-survival-of-murine-auditory-neuroblasts
#8
Marina Bruno, Ilaria Maria Rizzo, Ricardo Romero-Guevara, Caterina Bernacchioni, Francesca Cencetti, Chiara Donati, Paola Bruni
Hearing loss affects millions of people in the world. In mammals the auditory system comprises diverse cell types which are terminally differentiated and with no regenerative potential. There is a tremendous research interest aimed at identifying cell therapy based solutions or pharmacological approaches that could be applied therapeutically alongside auditory devices to prevent hair cell and neuron loss. Sphingosine 1-phosphate (S1P) is a pleiotropic bioactive sphingolipid that plays key role in the regulation of many physiological and pathological functions...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28188422/regulation-of-seedling-growth-by-ethylene-and-the-ethylene-auxin-crosstalk
#9
REVIEW
Yuming Hu, Filip Vandenbussche, Dominique Van Der Straeten
This review highlights that the auxin gradient, established by local auxin biosynthesis and transport, can be controlled by ethylene, and steers seedling growth. A better understanding of the mechanisms in Arabidopsis will increase potential applications in crop species. In dark-grown Arabidopsis seedlings, exogenous ethylene treatment triggers an exaggeration of the apical hook, the inhibition of both hypocotyl and root elongation, and radial swelling of the hypocotyl. These features are predominantly based on the differential cell elongation in different cells/tissues mediated by an auxin gradient...
February 10, 2017: Planta
https://www.readbyqxmd.com/read/28184337/atoh1-as-a-coordinator-of-sensory-hair-cell-development-and-regeneration-in-the-cochlea
#10
Sungsu Lee, Han-Seong Jeong, Hyong-Ho Cho
Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement of cell replacement therapies for hearing loss. Transcription factor Atoh1 is the key player during HC development and regeneration. In this review, we will focus on Atoh1 and its related signaling pathways (Notch, fibroblast growth factor, and Wnt/β-catenin signaling) involved in the development of cochlear sensory HCs...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28176951/in-vitro-and-in-vivo-evaluation-of-biologically-synthesized-silver-nanoparticles-for-topical-applications-effect-of-surface-coating-and-loading-into-hydrogels
#11
Aml I Mekkawy, Mohamed A El-Mokhtar, Nivien A Nafady, Naeima Yousef, Mostafa A Hamad, Sohair M El-Shanawany, Ehsan H Ibrahim, Mahmoud Elsabahy
In the present study, silver nanoparticles (AgNPs) were synthesized via biological reduction of silver nitrate using extract of the fungus Fusarium verticillioides (green chemistry principle). The synthesized nanoparticles were spherical and homogenous in size. AgNPs were coated with polyethylene glycol (PEG) 6000, sodium dodecyl sulfate (SDS), and β-cyclodextrin (β-CD). The averaged diameters of AgNPs were 19.2±3.6, 13±4, 14±4.4, and 15.7±4.8 nm, for PEG-, SDS-, and β-CD-coated and uncoated AgNPs, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28169594/keratin-hydrogel-enhances-in-vivo-skeletal-muscle-function-in-a-rat-model-of-volumetric-muscle-loss
#12
Juliana A Passipieri, Hannah B Baker, Mevan Siriwardane, Mary Ellenburg, Manasi Vadhavkar, Justin M Saul, Seth Tomblyn, Luke Burnett, George Joseph Christ
Volumetric Muscle Loss (VML) injuries exceed the considerable intrinsic regenerative capacity of skeletal muscle resulting in permanent functional and cosmetic deficits. VML and VML-like injuries occur in military and civilian populations, due to trauma and surgery as well as a host of congenital and acquired diseases/syndromes. Current therapeutic options are limited, and new approaches are needed for more complete functional regeneration of muscle. A potential solution is human hair derived keratin (KN) biomaterials that may have significant potential for regenerative therapy...
February 7, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28168533/zinc-sulfate-and-or-growth-hormone-administration-for-the-prevention-of-radiation-induced-dermatitis-a-placebo-controlled-rat-model-study
#13
Mustafa Kandaz, Mustafa Vecdi Ertekin, İhsan Karslıoğlu, Fazlı Erdoğan, Orhan Sezen, Akçahan Gepdiremen, Cemal Gündoğdu
Growth hormone (GH) and zinc (Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague-Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d(-1) GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d(-1) Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0...
February 6, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28167701/aba-suppresses-root-hair-growth-via-obp4-transcriptional-regulator-repression-of-the-rsl2-promoter
#14
Bart Rymen, Ayako Kawamura, Sabine Schaefer, Christian Breuer, Akira Iwase, Michitaro Shibata, Miho Ikeda, Nobutaka Mitsuda, Csaba Koncz, Masaru Ohme-Takagi, Minami Matsui, Keiko Sugimoto
Plants modify organ growth and tune morphogenesis in response to various endogenous and environmental cues. At the cellular level, organ growth is often adjusted by alterations in cell growth but molecular mechanisms underlying this control remain poorly understood. In this study, we identify the DOF-type transcription regulator OBP4 as a repressor of cell growth. Ectopic expression of OBP4 in Arabidopsis inhibits cell growth resulting in severe dwarfism and repression of genes involved in the regulation of water transport, root hair development and stress responses...
February 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28163457/near-infrared-pulsed-light-for-permanent-hair-reduction-in-fitzpatrick-skin-types-iv-and-v
#15
Pratik Thacker, Pramod Kumar
BACKGROUND: Excessive hair on the face is a significant cause for distress amongst women. Permanent hair reduction methods including lasers and pulsed light devices are increasingly being used. AIMS: The aim of this study is to evaluate the efficacy and safety of near infrared pulsed light source for permanent hair reduction in women seeking treatment for excessive hair growth on the upper lip and chin. SETTINGS AND DESIGN: This was a prospective observational study done at a tertiary care hospital in South India...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28162053/cell-and-growth-factor-loaded-keratin-hydrogels-for-treatment-of-volumetric-muscle-loss-vml-in-a-mouse-model
#16
Hannah B Baker, Juliana A Passipieri, Mevan Siriwardane, Mary Ellenburg, Manasi Vadhavkar, Christopher R Bergman, Justin M Saul, Seth Tomblyn, Luke Burnett, George Joseph Christ
Wounds to the head, neck and extremities have been estimated to account for ~84% of reported combat injuries to military personnel. Volumetric muscle loss (VML), defined as skeletal muscle injuries in which tissue loss results in permanent functional impairment, are common among these injuries. The present standard of care entails the use of muscle flap transfers, which suffer from the need for additional surgery when using autografts or the risk of rejection when cadaveric grafts are used. Tissue engineering (TE) strategies for skeletal muscle repair have been investigated as a means to overcome current therapeutic limitations...
February 4, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28157540/large-intragenic-deletion-in-dstyk-underlies-autosomal-recessive-complicated-spastic-paraparesis-spg23
#17
John Y W Lee, Chao-Kai Hsu, Magdalene Michael, Arti Nanda, Lu Liu, James R McMillan, Celine Pourreyron, Takuya Takeichi, Jakub Tolar, Evan Reid, Thomas Hayday, Sergiu C Blumen, Saif Abu-Mouch, Rachel Straussberg, Lina Basel-Vanagaite, Yael Barhum, Yasmin Zouabi, Hejab Al-Ajmi, Hsin-Yu Huang, Ting-Chien Lin, Masashi Akiyama, Julia Y Y Lee, W H Irwin McLean, Michael A Simpson, Maddy Parsons, John A McGrath
SPG23 is an autosomal-recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy pigment loss during childhood. Previously, genome-wide linkage in an Arab-Israeli pedigree mapped the gene to an approximately 25 cM locus on chromosome 1q24-q32. By using whole-exome sequencing in a further Palestinian-Jordanian SPG23 pedigree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affected family members...
February 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28155238/dickkopf-1-is-involved-in-dexamethasone-mediated-hair-follicle-regression
#18
Mi Hee Kwack, Jun Ho Lee, Chang Hoon Seo, Jung Chul Kim, Moon Kyu Kim, Young Kwan Sung
The stress-related neurohormones including glucocorticoids (GCs) are secreted by hair follicles (HFs) and GCs suppress murine hair growth in vivo. In this study, we found that dexamethasone (Dex), a synthetic GC, increased the expression of dickkopf-1 (DKK1), a known catagen inducer, in dermal papilla (DP) cells but not in follicular keratinocytes. The neutralizing DKK1 antibody significantly attenuated the Dex-induced inhibition of human hair shaft elongation. In addition, the neutralizing Dkk1 antibody delayed Dex-induced catagen in mice...
February 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28153354/sport-and-sample-specific-features-of-trace-elements-in-adolescent-female-field-hockey-players-and-fencers
#19
Alexey A Nabatov, Natalya A Troegubova, Ruslan R Gilmutdinov, Andrey P Sereda, Alexander S Samoilov, Natalya V Rylova
Active physical exercises and growth are associated with mineral imbalances in young athletes. The purpose of this study was to examine the impact of sport-related factors on tissue mineral status in adolescent female athletes. Saliva and hair samples were used for the analysis of immediate and more permanent tissue mineral status, respectively. Samples taken from a control non-athletic female group and two groups of female athletes (field hockey and fencing) were analyzed for seven essential minerals: calcium, chromium, iron, potassium, magnesium, selenium and zinc...
November 5, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28150693/phcesa3-silencing-inhibits-elongation-and-stimulates-radial-expansion-in-petunia
#20
Weiyuan Yang, Yuanping Cai, Li Hu, Qian Wei, Guoju Chen, Mei Bai, Hong Wu, Juanxu Liu, Yixun Yu
Cellulose synthase catalytic subunits (CESAs) play important roles in plant growth, development and disease resistance. Previous studies have shown an essential role of Arabidopsis thaliana CESA3 in plant growth. However, little is known about the role of CESA3 in species other than A. thaliana. To gain a better understanding of CESA3, the petunia (Petunia hybrida) PhCESA3 gene was isolated, and the role of PhCESA3 in plant growth was analyzed in a wide range of plants. PhCESA3 mRNA was present at varying levels in tissues examined...
February 2, 2017: Scientific Reports
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