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https://www.readbyqxmd.com/read/28916740/mad2b-acts-as-a-negative-regulatory-partner-of-tcf4-on-proliferation-in-human-dermal-papilla-cells
#1
Nanlan Yu, Zhiqiang Song, Kezhou Zhang, Xichuan Yang
Dermal papilla cells (DPCs) are important components of hair follicles and play a critical role in hair follicle development. However, the mechanisms by which DPCs induce hair follicle development remain unclear. In the present study, we identified the mitotic arrest deficient protein MAD2B as a modifier of DPCs. Overexpression of MAD2B inhibited DPC aggregative growth and proliferation induced by the Wnt signaling activator T cell factor 4 (TCF4), and decreased TCF4-induced expression and the release of hair growth-related cytokines, including hepatocyte growth factor, insulin-like growth factor-1, and vascular endothelial growth factor in DPCs...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28913895/nramp2-a-trans-golgi-network-localized-manganese-transporter-is-required-for-arabidopsis-root-growth-under-manganese-deficiency
#2
Huiling Gao, Wenxiang Xie, Changhong Yang, Jingyi Xu, Jingjun Li, Hua Wang, Xi Chen, Chao-Feng Huang
To cope with manganese (Mn) deficiency, plants have evolved an efficient transport system to uptake and redistribute Mn. However, the underlying molecular mechanisms remain to be demonstrated. We carried out a forward genetic screen in a root high-affinity Mn transporter nramp1 mutant background in Arabidopsis thaliana and identified an uncharacterized Mn transport NRAMP2. We investigated the effect of nramp2 mutation on root growth and reactive oxygen species (ROS) accumulation and we also examined the NRAMP2 expression pattern, and the subcellular localization and transport activity of NRAMP2...
September 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/28913304/trichilemmal-carcinoma-from-proliferating-trichilemmal-cyst-on-the-posterior-neck
#3
Ui Geon Kim, Dong Bee Kook, Tae Hun Kim, Chung Hun Kim
Trichilemmal cysts are common fluid-filled growths that arise from the isthmus of the hair follicle. They can form rapidly multiplying trichilemmal tumors-, also called proliferating trichilemmal cysts, which are typically benign. Rarely, proliferating trichilemmal cysts can become cancerous. Here we report the case of a patient who experienced this series of changes. The 27-year-old male patient had been observed to have a 1×1 cm cyst 7 years ago. Eight months prior to presentation at our institution, incision and drainage was performed at his local clinic...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912796/a-low-cost-imaging-method-for-the-temporal-and-spatial-colorimetric-detection-of-free-amines-on-maize-root-surfaces
#4
Truc H Doan, Tu A Doan, Michael J Kangas, AdreAnna E Ernest, Danny Tran, Christina L Wilson, Andrea E Holmes, Erin L Doyle, Tessa L Durham Brooks
Plant root exudates are important mediators in the interactions that occur between plants and microorganisms in the soil, yet much remains to be learned about spatial and temporal variation in their production. This work outlines a method utilizing a novel colorimetric paper to detect spatial and temporal changes in the production of nitrogen-containing compounds on the root surface. While existing methods have made it possible to conduct detailed analysis of root exudate composition, relatively less is known about where in the root system exudates are produced and how this localization changes as the root grows...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28912581/secretory-phospholipase-a2-iia-overexpressing-mice-exhibit-cyclic-alopecia-mediated-through-aberrant-hair-shaft-differentiation-and-impaired-wound-healing-response
#5
Gopal L Chovatiya, Rahul M Sarate, Raghava R Sunkara, Nilesh P Gawas, Vineet Kala, Sanjeev K Waghmare
Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs). Our data showed that overexpression of sPLA2-IIA in homozygous mice results in hyperproliferation and terminal epidermal differentiation followed by hair follicle cycle being halted at anagen like stage...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911317/generation-of-ips-derived-model-cells-for-analyses-of-hair-shaft-differentiation
#6
Takumi Kido, Tomoatsu Horigome, Minori Uda, Naoki Adachi, Yohei Hirai
Biological evaluation of hair growth/differentiation activity in vitro has been a formidable challenge, primarily due to the lack of relevant model cell systems. To solve this problem, we generated a stable model cell line in which successive differentiation via epidermal progenitors to hair components is easily inducible and traceable. Mouse induced pluripotent stem (iPS) cell-derived cells were selected to stably express a tetracycline (Tet)-inducible bone morphogenic protein-4 (BMP4) expression cassette and a luciferase reporter driven by a hair-specific keratin 31 gene (krt31) promoter (Tet-BMP4-KRT31-Luc iPS)...
September 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28911019/early-arabidopsis-root-hair-growth-stimulation-by-pathogenic-strains-of-pseudomonas-syringae
#7
Tamara Pecenková, Martin Janda, Jitka Ortmannová, Vladimíra Hajná, Zuzana Stehlíková, Viktor Žárský
Background and Aims: Selected beneficial Pseudomonas spp. strains have the ability to influence root architecture in Arabidopsis thaliana by inhibiting primary root elongation and promoting lateral root and root hair formation. A crucial role for auxin in this long-term (1week), long-distance plant-microbe interaction has been demonstrated. Methods: Arabidopsis seedlings were cultivated in vitro on vertical plates and inoculated with pathogenic strains Pseudomonas syringae pv...
September 1, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28906436/development-and-evaluation-of-a-manganese-and-iron-food-frequency-questionnaire-for-pediatrics
#8
Frida B Zipkin, Grace A Falciglia, Pierce Kuhnell, Erin N Haynes
Manganese (Mn) is an essential nutrient, but overexposure can lead to neurotoxicity. Given the essentiality of Mn in the diet, particularly during children's growth and development, it is imperative to quantify dietary Mn intake in populations that may be exposed to industrial sources of Mn. Dietary absorption of Mn is inversely associated with iron (Fe) stores, yet there is currently no food frequency questionnaire (FFQ) to assess dietary Mn and Fe intake. The study objective was to develop and evaluate the validity of a FFQ to measure dietary Mn and Fe intake in pediatrics by comparing the estimated intakes of Mn and Fe with biomarkers: Mn in blood and hair and Fe in serum...
September 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28905175/the-promotion-of-hair-regrowth-by-topical-application-of-a-perilla-frutescens-extract-through-increased-cell-viability-and-antagonism-of-testosterone-and-dihydrotestosterone
#9
Jing-Jie Li, Zheng Li, Li-Juan Gu, Kang-Ju Choi, Dong-Seon Kim, Ho-Kyoung Kim, Chang-Keun Sung
This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P. frutescens suspended in distilled water, where the resultant aqueous suspension was fractionated sequentially using hexane, ethyl acetate, n-butanol, and distilled water. We observed that the n-butanol fraction resulted in the highest hair regrowth activity. The n-butanol soluble fraction of P. frutescens extract (BFPE) was further separated using AB-8 macroporous resin and silica gel chromatography to obtain rosmarinic acid (RA), which demonstrated effective hair growth regeneration potential...
September 13, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28903047/caloric-restriction-promotes-structural-and-metabolic-changes-in-the-skin
#10
Maria Fernanda Forni, Julia Peloggia, Tárcio T Braga, Jesús Eduardo Ortega Chinchilla, Jorge Shinohara, Carlos Arturo Navas, Niels Olsen Saraiva Camara, Alicia J Kowaltowski
Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR mice display fur coat remodeling associated with an expansion of the hair follicle stem cell (HFSC) pool. We also find that the dermal adipocyte depot (dWAT) is underdeveloped in CR animals. The dermal/vennule annulus vasculature is enlarged, and a vascular endothelial growth factor (VEGF) switch and metabolic reprogramming in both the dermis and the epidermis are observed...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28894702/effects-of-hair-metals-on-body-weight-in-iranian-children-aged-20-to-36-months
#11
Mohsen Vigeh, Kazuhito Yokoyama, Takehisa Matsukawa, Atsuko Shinohara, Mamak Shariat, Katsumi Ohtani
BACKGROUND: Although the level of exposure to many toxic metals decreased recently, the adverse effects of these metals on children's growth and development remain a serious public health issue. METHODS: The present study was conducted in three teaching hospitals affiliated with Tehran University of Medical Sciences (Tehran, Iran) from Sep 2012 to Mar 2013. To study the relationship between metals and childhood growth, concentrations of zinc and several potentially toxic metals (lead, cadmium, antimony, cobalt, and molybdenum) were measured in scalp hair for 174 children, aged 20 to 36 months...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28892761/ethyl-glucuronide-in-keratinous-matrices-as-biomarker-of-alcohol-use-a-correlation-study-between-hair-and-nails
#12
Delphine Cappelle, Hugo Neels, Steven De Keukeleire, Erik Fransen, Geert Dom, Annemie Vermassen, Adrian Covaci, Cleo L Crunelle, Alexander L N van Nuijs
To quantify alcohol use, objective, specific and sensitive long-term alcohol markers are necessary. Ethyl glucuronide (EtG), a direct metabolite of alcohol, accumulates in keratinous matrices such as hair and nails, and is a specific and sensitive long-term biomarker for the detection of chronic alcohol consumption. So far, research has primarily focused on the detection of EtG in hair, and studies on its measurement in nails are scarce. In this article, we assessed EtG concentrations in hair, finger- and toenails from the same individuals in order to evaluate the direct correlation between the matrices...
August 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28888217/epidermal-growth-factor-receptor-inhibitors-cutaneous-side-effects-and-their-management
#13
S Monjazeb, J Wilson
Epidermal growth factor receptor (EGFR) inhibitors are part of an emerging class of anticancer medicines known as "targeted therapy," which target pathways more specific to neoplastic proliferation than traditional chemotherapeutic agents. Adverse effects of such treatments are thought to be less severe, but can still be significant. Because EGFR is preferentially expressed in epithelial tissues, including the skin and hair follicle, cutaneous side effects of these agents are quite common. Not only can these toxicities severely affect patients' quality of life, but in some specific instances, they can be associated with increased response to therapy...
September 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28887865/plasma-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#14
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28885585/hair-regenerative-mechanisms-of-red-ginseng-oil-and-its-major-components-in-the-testosterone-induced-delay-of-anagen-entry-in-c57bl-6-mice
#15
Van-Long Truong, Min Ji Bak, Changook Lee, Mira Jun, Woo-Sik Jeong
Hair loss (alopecia) is a universal problem for numerous people in the world. The present study was conducted to investigate the effects of red ginseng oil (RGO) and its major components on hair re-growth using testosterone (TES)-induced delay of anagen entry in C57BL/6 mice and their mechanisms of action. Seven-week-old C57BL/6 mice were daily treated with TES for 1 h prior to topical application of 10% RGO, 1% linoleic acid (LA), 1% β-sitosterol (SITOS), or 1% bicyclo(10.1.0)tridec-1-ene (BICYCLO) once a day for 28 days...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28884378/efficacy-of-topical-tofacitinib-in-promoting-hair-growth-in-non-scarring-alopecia-possible-mechanism-via-vegf-induction
#16
Jitlada Meephansan, J Thummakriengkrai, S Ponnikorn, W Yingmema, R Deenonpoe, P Suchonwanit
Tofacitinib is a Janus kinase 3 (JAK3) inhibitor that promotes hair growth; however, the efficacy and mechanism of this effect are not yet understood. This study aimed to evaluate the efficacy and mechanism of topical tofacitinib on hair growth in mice. Eight-week-old male C57BL/6 mice were divided equally into four groups and treated topically with tofacitinib, minoxidil, or vehicle once daily for 21 days. Weekly photographs were taken to determine the area and rate of hair growth, and tissue samples were collected for histopathological evaluation...
September 7, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28879195/a-review-of-the-use-of-biotin-for-hair-loss
#17
REVIEW
Deepa P Patel, Shane M Swink, Leslie Castelo-Soccio
BACKGROUND: Biotin has gained commercial popularity for its claimed benefits on healthy hair and nail growth. Despite its reputation, there is limited research to support the utility of biotin in healthy individuals. OBJECTIVE: To systematically review the literature on biotin efficacy in hair and nail growth. METHODS: We conducted a PubMed search of all case reports and randomized clinical trials (RCTs) using the following terms: (biotin and hair); (biotin and supplementation and hair); (biotin supplementation); (biotin and alopecia); (biotin and nails); (biotin and dermatology), and (biotin recommendations)...
August 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28878338/the-clinical-characteristics-of-asian-patients-with-classical-type-hutchinson-gilford-progeria-syndrome
#18
Nanae Sato-Kawano, Minoru Takemoto, Emiko Okabe, Koutaro Yokote, Muneaki Matsuo, Rika Kosaki, Kenji Ihara
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder that shows a characteristic progeria phenotype. We conducted a questionnaire survey of 1173 tertiary hospitals in Japan and reviewed the academic reports, to identify the characteristics of Asian patients with classical HGPS. As a result, four Japanese patients were identified; this was estimated to account for approximately two-third of the prevalence in Japan. Three Asian patients who had definitively been diagnosed with classical HGPS were identified in the literature; in total, the clinical characteristics of seven patients were evaluated...
September 7, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28875863/the-basic-mechanism-of-hair-growth-stimulation-by-adipose-derived-stem-cells-and-their-secretory-factors
#19
Chong-Hyun Won, Gyeong-Hun Park, Xunwei Wu, Thanh-Nga Tran, Ki-Young Park, Byung-Soon Park, Dong Young Kim, Ohsang Kwon, Kyu-Han Kim
Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) within the stromal vascular fraction of subcutaneous adipose tissue. ADSCs secrete growth factors and other proteins, and have been used to regenerate skin with satisfactory results. ADSCs promote hair growth in vitro, ex vivo, and in vivo. The conditioned media of ADSCs (ADSC-CM) increases the proliferation rate of human follicular cells. ADSCs-derived proteins improve hair growth and protect human dermal papilla cells against cytotoxic injury caused by androgen and reactive oxygen species...
August 29, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28871204/higher-order-assembly-of-crystalline-cylindrical-micelles-into-membrane-extendable-colloidosomes
#20
Hongjing Dou, Mei Li, Yan Qiao, Robert Harniman, Xiaoyu Li, Charlotte E Boott, Stephen Mann, Ian Manners
Crystallization-driven self-assembly of diblock copolymers into cylindrical micelles of controlled length has emerged as a promising approach to the fabrication of functional nanoscale objects with high shape anisotropy. Here we show the preparation of a series of crystallizable diblock copolymers with appropriate wettability and chemical reactivity, and demonstrate their self-assembly into size-specific cylindrical micelle building blocks for the hierarchical construction of mechanically robust colloidosomes with a range of membrane textures, surface chemistries and optical properties...
September 4, 2017: Nature Communications
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