Jeonghwan Youk, Taewoo Kim, Kelly V Evans, Young-Il Jeong, Yongsuk Hur, Seon Pyo Hong, Je Hyoung Kim, Kijong Yi, Su Yeon Kim, Kwon Joong Na, Thomas Bleazard, Ho Min Kim, Mick Fellows, Krishnaa T Mahbubani, Kourosh Saeb-Parsy, Seon Young Kim, Young Tae Kim, Gou Young Koh, Byeong-Sun Choi, Young Seok Ju, Joo-Hyeon Lee
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the cause of a present pandemic, infects human lung alveolar type 2 (hAT2) cells. Characterizing pathogenesis is crucial for developing vaccines and therapeutics. However, the lack of models mirroring the cellular physiology and pathology of hAT2 cells limits the study. Here, we develop a feeder-free, long-term, three-dimensional (3D) culture technique for hAT2 cells derived from primary human lung tissue and investigate infection response to SARS-CoV-2...
October 21, 2020: Cell Stem Cell