Guidong Shi, Nakagawa Koichi, Rou Wan, Yicun Wang, Ramona Reisdorf, Abigayle Wilson, Tony C T Huang, Peter C Amadio, Alexander Meves, Chunfeng Zhao, Steven L Moran
BACKGROUND: Prevention of adhesion formation following flexor tendon repair is essential for restoration of normal finger function. Although many medications have been studied in the experimental setting to prevent adhesions, clinical application is limited due to the complexity of application and delivery in clinical translation. METHODS: In this study, optimal dosages of gelatin and pentamidine were validated by gelatin concentration test. Following cell viability, cell migration, live and dead cell, and cell adhesion assay of the Turkey tenocytes, a model of Turkey tendon repair was established to evaluate the effectiveness of the Pentamidine-Gelatin sheet...
March 2024: Journal of Orthopaedic Translation