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JOURNAL ARTICLE
Lindsey J Wanberg, David R Pearson
BACKGROUND: Lupus erythematosus (LE) is an autoimmune condition that is associated with significant detriments to quality of life and daily functioning. TikTok, a popular social networking platform for sharing short videos, provides a unique opportunity to understand experiences with LE within a nonclinical sample, a population that is understudied in LE research. This is the first qualitative study that explores LE experiences using the TikTok platform. OBJECTIVE: This study aims to evaluate the disease-related experiences of TikTok users with LE using qualitative and content analysis...
April 17, 2024: JMIR Infodemiology
#2
REVIEW
Matthew C Pickering, Marina Botto
For many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function(s) of complement remains an important challenge for the future and has implications for the use of complement therapy in SLE...
April 17, 2024: European Journal of Immunology
#3
Ping Ren Tan, Aaron J L Lee, Joseph J Zhao, Yiong Huak Chan, Jia Hui Fu, Margaret Ma, Sen Hee Tay
INTRODUCTION: Periodontitis as a comorbidity in systemic lupus erythematosus (SLE) is still not well recognized in the dental and rheumatology communities. A meta-analysis and network meta-analysis were thus performed to compare the (i) prevalence of periodontitis in SLE patients compared to those with rheumatoid arthritis (RA) and (ii) odds of developing periodontitis in controls, RA, and SLE. METHODS: Pooled prevalence of and odds ratio (OR) for periodontitis were compared using meta-analysis and network meta-analysis (NMA)...
2024: Frontiers in Immunology
#4
Camilo Andrés Chaparro, Santiago Bernal-Macías, Oscar Mauricio Muñoz
Lupus enteritis denotes inflammation of the intestinal walls resulting from the influence of systemic lupus erythematosus. It represents a rare manifestation associated with notable morbidity and mortality, marked by nonspecific gastrointestinal symptoms. In this article, we present two cases of individuals experiencing severe gastrointestinal symptoms. They had a personal or familial history of autoimmunity with intestinal involvement consistent with the presentation of lupus enteritis. Following treatment with glucocorticoids and immunomodulators, both patients exhibited a satisfactory clinical evolution...
2024: SAGE Open Medical Case Reports
#5
JOURNAL ARTICLE
Mayumi Matsuda, Yu Funakubo Asanuma, Kyohei Emoto, Sakon Sakai, Nobuhito Okumura, Hiroaki Yazawa, Takashi Maruyama, Takuma Tsuzuki Wada, Kazuhiro Yokota, Yasuto Araki, Yuji Akiyama, Toshihide Mimura
Vaccines against coronavirus disease 2019 (COVID-19) have been distributed in most countries for the prevention of onset and aggravation of COVID-19. Recently, there have been increasing numbers of reports on new-onset autoimmune and autoinflammatory diseases following COVID-19 vaccination, however, only little information is available on the long-term safety of these vaccines. Here, we experienced three cases of new-onset rheumatic diseases following COVID-19 vaccination, one case each of rheumatoid arthritis (RA), anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE)...
April 16, 2024: Immunological Medicine
#6
JOURNAL ARTICLE
Laura Plantinga, Jinoos Yazdany, C Barrett Bowling, Charmayne Dunlop-Thomas, Courtney Hoge, Brad D Pearce, S Sam Lim, Patricia Katz
OBJECTIVE: Cognitive impairment is a common complaint in SLE, but approaches to measuring cognitive performance objectively vary. Leveraging data collected in a population-based cohort of individuals with validated SLE, we compared performance and potential impairment across multiple measures of cognition. METHODS: During a single study visit (October 2019-May 2022), times to complete the Trail Making Test B (TMTB; N=423) were recorded; potential impairment was defined as an age-corrected and education-corrected T-score <35 (>1...
April 16, 2024: Lupus Science & Medicine
#7
JOURNAL ARTICLE
Kale S Bongers, Angeline Massett, David N O'Dwyer
Connective tissue disease-related interstitial lung disease (CTD-ILD) is a frequent and serious complication of CTD, leading to high morbidity and mortality. Unfortunately, its pathogenesis remains poorly understood; however, one intriguing contributing factor may be the microbiome of the mouth and lungs. The oral microbiome, which is a major source of the lung microbiome through recurrent microaspiration, is altered in ILD patients. Moreover, in recent years, several lines of evidence suggest that changes in the oral and lung microbiota modulate the pulmonary immune response and thus may play a role in the pathogenesis of ILDs, including CTD-ILD...
April 16, 2024: Seminars in Respiratory and Critical Care Medicine
#8
JOURNAL ARTICLE
Mengna Zhao, Na Peng, Yingbo Zhou, Yuan Qu, Meng Cao, Qinghua Zou, Qinghong Yu, Liwei Lu, Fan Xiao
Total glucoside of paeonia (TGP) and its main active ingredient paeoniflorin, extracted from the Chinese herb Paeonia Lactiflora Pallas, exhibit potent immunomodulatory effects. TGP has been shown to inhibit inflammatory responses and disease progression in experimental models of multiple autoimmune diseases (AIDs), including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, psoriasis, etc. TGP shows broad immunomodulatory effects on many immune cells such as T cells, macrophages, and dendritic cells, by regulating their activation, proliferation, differentiation, and production of effector molecules...
April 16, 2024: Journal of Leukocyte Biology
#9
REVIEW
Dilara Bulut Gökten, Murat Gökten, Çiğdem Deniz, Rıdvan Mercan
Moyamoya syndrome (MMS) is a rare, chronic, progressive cerebrovascular disorder characterized by stenosis at the apices of the intracranial internal carotid arteries, including the proximal anterior cerebral arteries and middle cerebral arteries. Cerebral angiography images are used for detection through measurement. Systemic lupus erythematosus (SLE) is an autoimmune disease that can cause multisystemic involvement. The coexistence of SLE and MMS has been rarely reported in the literature. A 46-year-old male patient with malar rash, Raynaud phenomenon presented to the hospital with a complaint of weakness in the left lower extremity, which began 3 days before the date of the visit...
April 16, 2024: Clinical Rheumatology
#10
JOURNAL ARTICLE
Brendyn M St Louis, Sydney M Quagliato, Yu-Ting Su, Gregory Dyson, Pei-Chung Lee
UNLABELLED: The Hippo kinases MST1 and MST2 initiate a highly conserved signaling cascade called the Hippo pathway that limits organ size and tumor formation in animals. Intriguingly, pathogens hijack this host pathway during infection, but the role of MST1/2 in innate immune cells against pathogens is unclear. In this report, we generated Mst1/2 knockout macrophages to investigate the regulatory activities of the Hippo kinases in immunity. Transcriptomic analyses identified differentially expressed genes (DEGs) regulated by MST1/2 that are enriched in biological pathways, such as systemic lupus erythematosus, tuberculosis, and apoptosis...
April 16, 2024: MBio
#11
JOURNAL ARTICLE
Stanislav Hresko, Martina Madarova, Miroslava Dobosova, Nikola Palusekova, Petra Niznerova, Stanislav Ziaran, Ivan Varga
C4d, a split product of C4 activation in classical and lectin pathways of the complement system activation, has been regarded as a footprint of tissue damage in antibody-mediated rejection in transplantology. The introduction of C4d staining into daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in kidney allograft rejection. However, this marker of complement activation is also important in other various kidney glomerular pathologies such as immunoglobulin A nephropathy, membranoproliferative glomerulonephritis, lupus nephritis, and others...
2024: Bratislavské Lekárske Listy
#12
JOURNAL ARTICLE
Rina Moriyama, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai
OBJECTIVE: This study aimed to investigate the role of the programmed cell death protein 1 (PD-1) pathway and T peripheral helper (Tph) cells in the pathogenesis of lupus nephritis using lupus-prone BXSB- Yaa mice. METHODS: Male BXSB- Yaa mice and age-matched male C57BL/6 mice were used. The expression of PD-1 and its ligands (programmed cell death 1 ligand-1, PD-L1 and programmed cell death 1 ligand-2, PD-L2) and the phenotypes of kidney-derived cells and splenocytes expressing these molecules were analyzed by immunofluorescence and flow cytometry...
April 15, 2024: Lupus
#13
REVIEW
Zhenle Yang, Qian Li, Suwen Liu, Zihan Zong, Lichun Yu, Shuzhen Sun
BACKGROUND: Systemic lupus erythematosus (SLE) and Wilson's disease (WD) are both systemic diseases that can affect multiple organs in the body. The coexistence of SLE and WD is rarely encountered in clinical practice, making it challenging to diagnose. CASE REPORT: We present the case of a 9-year-old girl who initially presented with proteinuria, haematuria, pancytopenia, hypocomplementemia, and positivity for multiple autoantibodies. She was diagnosed with SLE, and her blood biochemistry showed elevated liver enzymes at the time of diagnosis...
April 15, 2024: BMC Pediatrics
#14
JOURNAL ARTICLE
Razan M Alajoleen, Liwu Li, Xin M Luo
Regulatory B (Breg) cells have been demonstrated to play an important role in the inhibition of a wide range of immunological responses, and they are absent or malfunction in autoimmune diseases like lupus. Breg cells can control immunological responses and keep the immune system in a balanced state by releasing immunosuppressive cytokines such as transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10), which in turn promote regulatory T (Treg) cells and reduce effector T cell responses. Breg cells have also been linked to the modulation of cancer immunity...
2024: Methods in Molecular Biology
#15
REVIEW
David S Pisetsky
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti-DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti-DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provoke nephritis and stimulation of cytokine production following uptake into innate immune cells and interaction with internal nucleic acid sensors...
April 15, 2024: Arthritis & Rheumatology
#16
JOURNAL ARTICLE
Dawn M E Bowdish, Vinod Chandran, Carol A Hitchon, Gilaad G Kaplan, J Antonio Avina-Zubieta, Paul R Fortin, Maggie J Larché, Gilles Boire, Anne-Claude Gingras, Roya M Dayam, Ines Colmegna, Luck Lukusa, Jennifer L F Lee, Dawn P Richards, Daniel Pereira, Tania H Watts, Mark S Silverberg, Charles N Bernstein, Diane Lacaille, Jenna Benoit, John Kim, Nadine Lalonde, Janet Gunderson, Hugues Allard-Chamard, Sophie Roux, Joshua Quan, Lindsay Hracs, Elizabeth Turnbull, Valeria Valerio, Sasha Bernatsky
OBJECTIVE: To determine how serologic responses to COVID vaccination/infection in immunemediated inflammatory disease (IMID) are affected by time since last vaccination and other factors. METHODS: Post-COVID-19 vaccination, data and dried blood spots/sera were collected from adults with rheumatoid arthritis, inflammatory bowel disease, systemic lupus, ankylosing spondylitis/spondylarthritis and psoriasis/psoriatic arthritis. First sample was at enrolment and then 2-4 weeks and 3, 6, and 12 months after latest vaccine dose...
April 15, 2024: Journal of Rheumatology
#17
JOURNAL ARTICLE
Sharath Gowda, Khushboo Rana, Ankit Kumar, Pradip Kumar Prajapati, Namisha Patel, Sapan Pandya, Ratika Srivastava
Major reason for mortality among systemic lupus erythematosus patients is renal failure due to the deposition of immune complexes in the glomeruli. Being a chronic disease with multiple relapses and remissions across the lifespan, it's important to know the degree of nephritis for diagnosis as well as the long-term clinical management of the patients. Currently, renal biopsy is being used as the gold standard to diagnose and define the stages of the disease. However, renal biopsy being invasive only provides a localized picture of nephritis, and has the risk of bleeding...
April 15, 2024: Lupus
#18
REVIEW
Maud Tusseau, Samira Khaldi-Plassart, Jade Cognard, Sebastien Viel, Liliane Khoryati, Sarah Benezech, Anne-Laure Mathieu, Fréderic Rieux-Laucat, Brigitte Bader-Meunier, Alexandre Belot
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by its large heterogeneity in terms of clinical presentation and severity. The pathophysiology of SLE involves an aberrant autoimmune response against various tissues, an excess of apoptotic bodies, and an overproduction of type-I interferon. The genetic contribution to the disease is supported by studies of monozygotic twins, familial clustering, and genome-wide association studies (GWAS) that have identified numerous risk loci...
April 15, 2024: Journal of Clinical Immunology
#19
JOURNAL ARTICLE
Qianwen Li, Zhi Yang, Kaili Chen, Ming Zhao, Hai Long, Yueming Deng, Haoran Hu, Chen Jia, Meiyu Wu, Zhidan Zhao, Huan Zhu, Suqing Zhou, Mingming Zhao, Pengpeng Cao, Shengnan Zhou, Yang Song, Guishao Tang, Juan Liu, Jiao Jiang, Wei Liao, Wenhui Zhou, Bingyi Yang, Feng Xiong, Suhan Zhang, Xiaofei Gao, Yiqun Jiang, Wei Zhang, Bo Zhang, Yan-Ling He, Liwei Ran, Chunlei Zhang, Wenting Wu, Quzong Suolang, Hanhuan Luo, Xiaojing Kang, Caoying Wu, Hongzhong Jin, Lei Chen, Qing Guo, Guangji Gui, Shanshan Li, Henan Si, Shuping Guo, Hong-Ye Liu, Xiguang Liu, Guo-Zhang Ma, Danqi Deng, Limei Yuan, Jianyun Lu, Jinrong Zeng, Xian Jiang, Xiaoyan Lyu, Liuqing Chen, Bin Hu, Juan Tao, Yuhao Liu, Gang Wang, Guannan Zhu, Zhirong Yao, Qianyue Xu, Bin Yang, Yu Wang, Yan Ding, Xianxu Yang, Hu Kai, Haijing Wu, Qianjin Lu
BACKGROUND: Lupus erythematosus (LE) is a spectrum of autoimmune diseases. Due to the complexity of cutaneous LE (CLE), clinical skin image-based artificial intelligence is still experiencing difficulties in distinguishing subtypes of LE. OBJECTIVES: We aim to develop a multimodal deep learning system (MMDLS) for human-AI collaboration in diagnosis of LE subtypes. METHODS: This is a multi-centre study based on 25 institutions across China to assist in diagnosis of LE subtypes, other eight similar skin diseases and healthy subjects...
April 15, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#20
JOURNAL ARTICLE
Yusuke Ueda, Tomoyuki Sakai, Kazunori Yamada, Kotaro Arita, Yoko Ishige, Daisuke Hoshi, Hiroto Yanagisawa, Haruka Iwao-Kawanami, Takafumi Kawanami, Shuichi Mizuta, Toshihiro Fukushima, Sohsuke Yamada, Akihiro Yachie, Yasufumi Masaki
Hemophagocytic lymphohistiocytosis (HLH) has been recognized as a rare adverse event following the coronavirus disease 2019 (COVID-19) vaccination. We report a case of neuropsychiatric symptoms and refractory HLH in a woman with systemic lupus erythematosus (SLE) after receiving her COVID-19 vaccine treated with belimumab, later found to have intravascular large B-cell lymphoma (IVLBCL) at autopsy. A 61-year-old woman with SLE was referred to our hospital because of impaired consciousness and fever. One month prior to consulting, she received her second COVID-19 vaccine dose...
April 15, 2024: Immunological Medicine
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