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Helicobacter 0

María Teresa Peralta Espejo, Alejandro Bussalleu Rivera, Vladimir Espinoza Ildefonso, Claudia Meza Borja, José Luis Rojas-Vilca
Objetive: To determine the diagnostic validity of an ammonia breath test for Helicobacter pylori infection in patients who undergo an upper gastrointestinal endoscopy at Hospital Cayetano Heredia. MATERIAL AND METHODS: From April to December 2014, 155 patients were evaluated with the ammonia breath test and compared with a histological evaluation of the gastric biopsies as the gold standard. Data were evaluated using Microsoft Excel and STATA 14 to build a ROC curve. RESULTS: The patients were predominantly female (71%), with a median age of 53 years (18-84) and a Helicobacter pylori prevalence of 51...
April 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Yoo Min Han, Su Jin Chung, Ji Min Choi, Changhyun Lee, Joo Sung Kim
AIM: According to the ABC system, the risk of gastric cancer (GC) is highest in group D (H. Pylori-negative and pepsinogen level-positive). The aim of this study is to assess the clinical characteristics and long-term outcome of group D. METHODS: Group D patients were divided into two groups; the limited endoscopic atrophic gastritis (EAG) group with EAG confined to antrum and angle (C1 and C2) and the advanced EAG group with body-involved EAG (C3 to O3). We compared progression of precursor lesions and occurrence of gastric neoplasms between the groups...
August 17, 2018: Journal of Digestive Diseases
Seung Joo Kang, Hwa Jung Kim, Donghee Kim, Aijaz Ahmed
We investigated the relationship of H. pylori stratified by cytotoxin-associated gene A (cagA) status with nonalcoholic fatty liver disease (NAFLD) in the general population of the United States (US). We utilized the Third National Health and Nutrition Examination Survey from 1988 to 1994 in this study. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other known causes of liver diseases and significant alcohol consumption. Hepatic steatosis was assessed by parenchymal brightness, liver to kidney contrast, deep beam attenuation, bright vessel walls and gallbladder wall definition...
2018: PloS One
Wolfgang Fischbach
BACKGROUND:  Data on colorectal lymphoma in general and on MALT (mucosa-associated-lymphoid tissue) lymphoma, in particular are, very rare. There are no existing recommendations from current guidelines for how to manage these patients. We here report our experience from a clinical series. AIM:  The aim of this study is to present clinical features and the endoscopic appearance of colorectal MALT lymphoma and therapeutic approaches. METHODS:  Seven patients (5 male and 2 female, aged 47 - 75 years) were diagnosed to have colorectal MALT lymphoma...
August 2018: Zeitschrift Für Gastroenterologie
Shih-Chi Wu, William Tzu-Liang Chen, Chih-Hsin Muo, Chung Y Hsu
OBJECTIVES: Hepatic parasympathetic nerves branch off the vagus nerve. The vagal and hepatic nervous systems are important in liver physiological processes and some diseases such as diabetes, obesity and liver cirrhosis. We were interested in vagal nerve integrity and subsequent diseases in peptic ulcer patients. Herein, we used National Health Insurance database in Taiwan and retrospectively assessed the risk of developing liver cirrhosis in peptic ulcer patients with and without complications by surgical treatments...
August 12, 2018: Journal of Gastroenterology and Hepatology
Nastaran Farzi, Catherine Behzad, Zahra Hasani, Masoud Alebouyeh, Homayoun Zojaji, Mohammad Reza Zali
Mixed infections and heteroresistance of Helicobacter pylori contribute to decreased efficacy of treatments. This study aimed to investigate frequency of clarithromycin heteroresistance and its link with mixed infections, medication history, and disease severity. A total of 40 pairs of H. pylori strains were isolated from the antrum and corpus of 97 patients. Susceptibility of the strains to clarithromycin was measured by agar dilution method. Site-specific mutations of 23S rRNA at A2143G, A2142G, and A2142C positions were analyzed by PCR and genomic relatedness of pairs of the strains was determined by random amplified polymorphic DNA (RAPD)-PCR...
August 10, 2018: Folia Microbiologica
Ângelo de Fátima, Camila de Paula Pereira, Carolina Raquel Said Dau Gonçalves Olímpio, Breno Germano de Freitas Oliveira, Lucas Lopardi Franco, Pedro Henrique Corrêa da Silva
Schiff bases, an aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, including anti-urease activity. Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms' health, since the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections...
September 2018: Journal of Advanced Research
Ahmed Mustafa, Naser E Bilal, Awad-Elkareem Abass, Elhassan M Elhassan, Ishag Adam
OBJECTIVE: To investigate the association between Helicobacter pylori seropositivity and low birthweight (LBW). METHODS: The present case-control study was conducted at a Sudanese maternity hospital from September fi1rst to December 30, 2015. Patients who delivered single neonates with LBW (>500 g but <2500 g) and the subsequent singleton delivery with birthweight of 2500-4000 g were included. A questionnaire was used to collect medical and obstetric data...
August 9, 2018: International Journal of Gynaecology and Obstetrics
Ying An, Ya Wang, Shuang Wu, You-Hua Wang, Xing Qian, Zhen Li, Ying-Jun Fu, Yong Xie
AIM: To assess the efficacy and safety of fourth-generation quinolones for Helicobacter pylori ( H. pylori ) eradication, we conducted this systematic review and meta-analysis of randomized clinical trials. METHODS: Major literature databases (PubMed, EMBASE and the Cochrane Central Register of Controlled Trials) were searched for relevant articles published prior to February 2018. We performed a meta-analysis of all randomized clinical trials that examined the efficacy of H...
August 7, 2018: World Journal of Gastroenterology: WJG
Renfei Zhu, Cheng Gao, Liuhua Wang, Guoxin Zhang, Weiming Zhang, Zhihong Zhang, Lizong Shen, Shoulin Wang
Background: Persistent Helicobacter pylori ( H. pylori ) infection leads to various gastric diseases. Multiple studies have demonstrated that aryl hydrocarbon receptor (AHR) plays roles in the antibacterial response and aryl hydrocarbon receptor repressor (AHRR) is downregulated in stomach cancer. However, the role of AHR or AHRR in H. pylori -related gastric diseases remains unclear. Aims: To investigate whether AHR or AHRR is involved in H. pylori -related gastric diseases. Methods: Patients with gastritis or gastric adenocarcinoma were enrolled randomly, and gastric tissue specimens were diagnosed pathologically...
2018: Journal of Cancer
Kanji Ohkuma, Hiroshi Iida, Yumi Inoh, Kenji Kanoshima, Hidenori Ohkubo, Takashi Nonaka, Koji Fujita, Akihiko Kusakabe, Masahiko Inamori, Atsushi Nakajima
To promote symptom relief from acid-related diseases, a medicine with a rapid-onset effect is ideal. The aim of this study was to investigate the early inhibitory effect on gastric acid secretion after a single oral administration of vonoprazan, which represents a new class of proton pump inhibitors, and to compare this effect with those of lansoprazole and famotidine. Ten Helicobacter pylori ( HP )-negative male subjects participated in this randomized, three-way crossover study. A single oral administration of vonoprazan (20 mg), lansoprazole (30 mg) or famotidine (20 mg) was performed, and the intragastric pH was continuously monitored for 6 h...
July 2018: Journal of Clinical Biochemistry and Nutrition
Ji Hyun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Oran Kwon, Hyesook Kim, Jeongseon Kim
Although the incidence of gastric cancer (GC) has declined, it remains the second most common cancer in Korea. As a class of phytochemicals, carotenoids are fat-soluble pigments that are abundant in fruits and vegetables and have health-promoting properties, including cancer prevention effects. This case-control study investigated the effects of total dietary carotenoids, dietary carotenoid subclasses (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene), and foods contributing to the dietary intake of each carotenoid on the risk of GC...
August 7, 2018: Nutrients
Lukmanul Hakkim, Seemaisamy Revathi, Govind Rajan, Gattu Sampath, Ramesh Kumar, Mohammed Al Buloshi, Sidgi Syed Anwar, Hamid Bakshi, Kayalvizhi Nagarajan
BACKGROUND: Colon cancer is the most aggressive form of cancers, that causes 0.5 million deaths per year around the globe. Targeting colon cancer by conventional therapeutic options elicits toxicity. Traditional medicines take lead to alleviate the existing clinical challenges. OBJECTIVE: To investigate anti bacterial activity against Helicobacter Pylori and in vitro anti colon cancer activity by Acacia nilotica extract (ACE) and its active constituent pyrogallol...
August 5, 2018: Anti-cancer Agents in Medicinal Chemistry
X Y Zhu, J Du, W J Zhao, J Wu, L W Zhao, X Meng, L Yang, L Jiao, H Ma
Objective: To investigate the efficacy and safety of Compound Lactobacillus Tablets or Saccharomyces boulardii Sachets combining with bismuth quadruple therapy for Helicobacter pylori ( H . pylori ) eradication. Methods: A total of 360 H . pylori - infected patients were enrolled and randomly assigned into three groups. Group A received esomeprazole 20 mg bid+ bismuth potassium citrate 220 mg bid+ amoxicillin 1 000 mg bid+ furazolidone 100 mg bid for 10 days. Group B or group C received the same quadruple therapy for 10 days as group A, as well as Compound Lactobacillus Tablets 1 000 mg tid or Saccharomyces boulardii Sachets 500 mg bid for 14 days...
July 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Mohadeseh Kosari-Monfared, Novin Nikbakhsh, Sadegh Fattahi, Elham Ghadami, Mohammad Ranaei, Hassan Taheri, Fatemeh Amjadi-Moheb, Gholam A Godazandeh, Shahryar Shafaei, Maryam Pilehchian-Langroudi, Ali A Samadani, Haleh Akhavan-Niaki
Gastric cancer is a life-threatening disease; resulting from interaction among genetic, epigenetic, and environmental factors. Aberrant dysregulation and methylation changes in Wnt/β-catenin signaling downstream elements are a prevalent phenomenon encountered in gastric tumorigenesis. Also, viral infections play a role in gastric cancer development. CTNNBIP1 (β-catenin interacting protein 1) gene is an antagonist of Wnt signaling which binds to the β-catenin molecules. The CTNNBIP1 function as tumor suppressor gene or oncogene in different types of cancer is controversial...
August 4, 2018: Journal of Cellular Physiology
Sandrine Coumes, Bruno Froissart, Nelly Wion, Fabian Reche, Catherine Arvieux, Anne-Laure Borel
PURPOSE: Helicobacter Pylori (HP) infection is systematically screened for before carrying out bariatric surgery. Criteria to determine "at risk" patients and avoid systematic screening are lacking. We evaluated the prevalence of HP infection and associated predictive factors in a population of patients with class II and III obesity volunteering for bariatric surgery. MATERIALS AND METHODS: Observational, cross-sectional study of patients included in the severe obesity outcome network (SOON) cohort...
August 3, 2018: Obesity Surgery
Nathan E Agbor, Seraphine N Esemu, Lucy M Ndip, Nicoline F Tanih, Stella I Smith, Roland N Ndip
OBJECTIVES: Helicobacter pylori is a pathogenic bacterium that parasitizes the gastric mucous layer and the epithelial lining of the stomach causing duodenal ulcers, gastric ulcers and cardiovascular disease amongst others. This study aimed at establishing the epidemiologic profile of H. pylori infection in gastritis patients presenting at the Melong District Hospital. RESULTS: Blood, stool and epidemiological data collected from 500 patients were analyzed for the presence of H...
August 3, 2018: BMC Research Notes
N Siupsinskiene, I Katutiene, V Jonikiene, D Janciauskas, S Vaitkus
OBJECTIVE: To determine the prevalence of Helicobacter pylori infection in nasal biopsy specimens from patients with chronic rhinosinusitis with polyposis versus control patients, and to assess the correlations between H pylori infection identified in the nasal tissue and patients' sociodemographic data and reflux-related symptoms and signs. METHODS: Nasal biopsy samples were taken from 75 adult patients who underwent nasal surgery for chronic rhinosinusitis with polyposis (clinical group, n = 45) and a deviated septum (control group, n = 30)...
August 3, 2018: Journal of Laryngology and Otology
L Ladrón-de-Guevara, L Bornstein-Quevedo, S González-Huezo, B Castañeda-Romero, F G Costa, M di Silvio-López
INTRODUCTION AND AIMS: Helicobacter pylori (H. pylori) infection remains the leading cause of several gastroduodenal diseases. Despite the fact that multiple antibiotic regimens have been used to change its associated morbidity and mortality, the prevalence of this bacterial infection continues to be disproportionately high worldwide, mainly due to antibiotic resistance. To assess the noninferiority efficacy and safety of 210-day triple regimens on H. pylori eradication, we evaluated clarithromycin 500mg, lansoprazole 30mg, and amoxicillin 1g, all bid (standard triple therapy or CLA, Group 1) vs...
July 27, 2018: Revista de Gastroenterología de México
Saleh Nazmy Mwafy, Wesam Mohammad Afana
Objective: This study aimed to investigate the relationship between hematological parameters, serum iron, and vitamin B12 levels in adult hospitalized Palestinian patients infected with Helicobacter pylori . Methods: This case-control study included 150 adult (18-50 years old) patients infected with H. pylori and 150 healthy adults. A complete blood count was performed, and serum iron and vitamin B12 levels of the patients were measured, statistically analyzed and compared with the control group...
April 2018: Hematology, transfusion and cell therapy
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