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Helicobacter 0

Mats Hall, Jörgen Wenner, Peter Scherman, Stefan Öberg
OBJECTIVE: Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. MATERIAL AND METHODS: Fifty asymptomatic volunteers and 149 patients with reflux symptoms underwent endoscopy with biopsies obtained from the gastric antrum and the squamocolumnar junction (SCJ)...
December 5, 2018: Scandinavian Journal of Gastroenterology
Michael Buenor Adinortey, Charles Ansah, Cynthia Ayefoumi Adinortey, Ansumana Sandy Bockarie, Martin Tangnaa Morna, Damian H Amewowor
Helicobacter pylori ( H. pylori ) is a gram-negative bacterium that colonizes the human stomach. Infection with this microaerophilic bacterium causes gastric and duodenal ulcer. This study sought to isolate H. pylori , from gastric biopsy samples of dyspeptic patients in Ghana using a 2,3,5-triphenyltetrazolium chloride (TTC) dye incorporated medium method. This TTC dye method was further used in an antimicrobial susceptibility assay involving Dissotis rotundifolia extract (DRE). H. pylori were successfully isolated from gastric biopsy of dyspeptic patients...
2018: Journal of Tropical Medicine
Zakaria Chakrani, Karen Robinson, Bineyam Taye
There is no consensus among the existing literature on the relationship between ABO blood groups and risk of Helicobacter pylori infection. However, histo-blood group carbohydrates are proposed to influence the risk of acquiring this pathogen via effects on adhesion to the gastric mucosa. The objective of this meta-analysis was to evaluate the association between ABO blood groups and H. pylori infection. All relevant epidemiological studies published in English (up to October 2017) was retrieved through an extensive systematic literature search of MEDLINE/PubMed databases...
December 4, 2018: Scientific Reports
Khitam Muhsen, Ronit Sinnreich, Gany Beer-Davidson, Hisham Nassar, Daniel Cohen, Jeremy D Kark
Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. A cross-sectional study was undertaken among 654 Jewish and 937 Arab residents of Jerusalem, aged 25-78 years, randomly selected from Israel's national population registry in age-sex and population strata. Sera were tested for H. pylori IgG, cytotoxin-associated gene A (CagA) antigen IgG antibody and PGs levels...
December 4, 2018: Scientific Reports
Jung H Son, Benjamin Lebwohl, Antonia R Sepulveda, Stephen M Lagana
BACKGROUND: Utilization rates of immunohistochemistry (IHC) for the diagnosis of Helicobacter pylori infection may vary by laboratory and/or pathologists. IHC for H. pylori is not performed routinely in our practice. Instead, it is used in selected cases at the pathologists' discretion (and according to their specific criteria). The purpose of this study was to determine if IHC utilization rates correlated with rates of detecting H. pylori infection. MATERIALS AND METHODS: We searched our records and investigated all gastric biopsies for 1 calendar year...
November 28, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Michelle Y L Tang, Patrick H Y Chung, Hau Y Chan, Paul K H Tam, Kenneth Ky Wong
OBJECTIVE: Helicobacter pylori infection is common among Asians. However, evidence in the recent years has demonstrated a decrease in the prevalence of H. pylori infection among children and adults worldwide. Our aim was to update its prevalence in symptomatic children in our locality in the recent 12 years and compared to the results of our previous review published in 2005. METHODS: A retrospective review was carried out between 2005 and 2017. All children who presented with dyspepsia or gastrointestinal bleeding and underwent oesophagogastroduodenoscopy with antral biopsy taken were included...
November 6, 2018: Journal of Pediatric Surgery
Mohammad Reza Abbaszadegan, Negin Taghehchian, Azadeh Aarabi, Meysam Moghbeli
PURPOSE: Gastric cancer (GC) is the third leading cause of cancer related deaths in the world. Cancer testis antigens (CTAs) are involved in tumor progression of various cancers. These markers have not any expression or minimally expression in normal tissues, highlighting them as efficient methods for molecular targeted therapy. In the present study, we assessed the role of MAEL as a CTA in biology of GC and risk of Helicobacter Pylori (H pylori) infection. METHODS: Levels of MAEL mRNA expression in 80 GC tumor tissues were compared to their corresponding normal margins using the real-time polymerase chain reaction...
November 28, 2018: Journal of Gastrointestinal Cancer
Po-Hao Liao, Yu-Chun Lin, Cheng-Hsin Chu, Shou-Chuan Shih, Tai-Cherng Liou
Background and aim: To assess the detection rates of Helicobacter pylori colonization in the gastric cardia with two commercial kits of rapid urease test: 5 min UFT300 and 24 h CLO test in H. pylori-infected patients. Methods: Eighty consecutive dyspeptic patients with confirmed H. pylori infection (serology and 13 C-urea breath test) were prospectively studied. During endoscopy, tissue samples using separate biopsy forceps from the cardia were taken for the UFT300 and CLO tests...
June 2018: JGH open: an open access journal of gastroenterology and hepatology
Izumi Nishikawa, Jun Kato, Satoshi Terasoma, Hiroyoshi Matsutani, Hidehiko Tamaki, Tetsuya Tamaki, Fumiaki Kuwashima, Hiroya Nakata, Tatsuji Tomeki, Hideyuki Matsunaka, Yumiko Ibata, Yasunobu Yamashita, Takao Maekita, Katsuhiko Higashi, Masao Ichinose
Background and Aim: Nodular gastritis is caused by Helicobacter pylori infection and is associated with the development of diffuse-type gastric cancer. This study examined the clinical characteristics of patients with nodular gastritis, including cancer incidence before and after H. pylori eradication. Methods: This was a retrospective study of patients who underwent upper endoscopy and were positive for H. pylori infection. We examined the clinical findings and follow-up data after H...
June 2018: JGH open: an open access journal of gastroenterology and hepatology
Bangshun He, Tao Xu, Bei Pan, Yuqin Pan, Xuhong Wang, Jingwu Dong, Huiling Sun, Xueni Xu, Xiangxiang Liu, Shukui Wang
Background: Helicobacter pylori ( H. pylori )-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune response. We hypothesized that genetic variations in genes of these pathways have potential susceptibility to gastric cancer risk, and predict clinical outcomes of patients. Methods: To investigate the susceptibility and prognostic value of genetic variations of IL - 16 , TGFBR1 and TLR4 pathways to gastric cancer, we performed a case-control study combined a retrospective study in a Chinese population...
2018: Cancer Cell International
Vincenzo De Francesco, Angelo Zullo, Giulia Fiorini, Ilaria M Saracino, Matteo Pavoni, Dino Vaira
Objectives: Antimicrobial resistance to clarithromycin and metronidazole significantly affects the cure rate of standard therapies for Helicobacter pylori infection. We tested whether different MIC levels of resistance to these antibiotics play a role in therapeutic efficacy. Methods: This was a post hoc analysis of data from a therapeutic trial in which patients with antibiotic susceptibility testing (Etest) received first-line sequential therapy. The level of antibiotic resistance was classified according to MIC values into low (MIC from >0...
November 26, 2018: Journal of Antimicrobial Chemotherapy
Hsiang Tso Huang, Hsin-Ming Wang, Shih-Cheng Yang, Wei-Chen Tai, Chih-Ming Liang, Keng-Liang Wu, Chen-Hsiang Lee, Seng-Kee Chuah
Purpose: To assess the efficacy of amoxicillin, tetracycline, high-dose metronidazole, and a proton-pump inhibitor for third-line Helicobacter pylori eradication. Methods: We enrolled 70 consecutive patients who had registered, failed to respond to two rounds of H. pylori eradication, and undergone endoscopy for H. pylori culture. Seven patients were lost to follow-up. Patients were treated according to the results of antibiotic-susceptibility testing reports (cultured group, n=39)...
2018: Infection and Drug Resistance
Ali M Al-Zubaidi, Abdo H Alzobydi, Saeed A Alsareii, AbdulazizTurky Al-Shahrani, Naweed Alzaman, Saba Kassim
Objective : We examine obese and non-obese patients with respect to Helicobacter pylori ( H. pylori ) positive-infection (HPPI) and associated factors, specifically body mass index (BMI). Methods : This study took place in the Department of Endoscopy of a central hospital in the Najran region of Saudi Arabia (SA). A total of 340 obese Saudi patients (BMI ≥ 30 kg/m²) who had undergone diagnostic upper endoscopy before sleeve gastrectomy, were compared with 340 age and gender-matched control patients (BMI < 30 kg/m²) who had undergone diagnostic upper endoscopy for other reasons...
November 19, 2018: International Journal of Environmental Research and Public Health
Jieun Jang, Eun-Jung Cho, Yunji Hwang, Elisabete Weiderpass, Choonghyun Ahn, Jeoungbin Choi, Soung-Hoon Chang, Hai-Rim Shin, Min Kyung Lim, Keun-Young Yoo, Sue K Park
Purpose: Few studies investigated roles of body mass index (BMI) on gastric cancer (GC) risk according to Helicobacter pylori infection status. This study was conducted to evaluate associations between BMI and GC risk with consideration of H. pylori infection information. Materials and Methods: We performed a case-cohort study (n=2,458) that consists of a subcohort, (n=2,193 including 67 GC incident cases) randomly selected from the Korean Multicenter Cancer Cohort (KMCC) and 265 incident GC cases outside of the subcohort...
November 21, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
David Bennett, Antonella Fossi, Giuseppina Chiarello, Rosa Metella Refini, Luca Luzzi, Piero Paladini, Maria Materozzi, Natale Figura, Ranuccio Nuti, Paola Rottoli
BACKGROUND: Helicobacter pylori (HP) is a spiral, gram-negative, microaerophilic bacterium that colonises the human gastric mucosa and is associated with gastrointestinal and extragastrointestinal disorders. Since no data are yet available on HP infection in lung transplant patients, we evaluated the prevalence and impact of HP infection in a population of such patients. METHODS: Sixty-seven lung transplant patients were enrolled in the study (35 females and 32 males, age 48...
November 19, 2018: Lung
Jean Ching-Yuan Fann, Tsung-Hsien Chiang, Amy Ming-Fang Yen, Yi-Chia Lee, Ming-Shiang Wu, Hsiu-Hsi Chen
BACKGROUND: To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model. METHODS: First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, including Helicobacter pylori infection, history of upper gastrointestinal disease, lifestyle, and dietary habits, on the step-by-step transition rates using data from a high-risk population in Matsu Islands, Taiwan...
November 19, 2018: Journal of Biomedical Science
Narihiro Shibukawa, Shohei Ouchi, Shuji Wakamatsu, Yuhei Wakahara, Akira Kaneko
BACKGROUND: The detection of early gastric cancer (GC) after Helicobacter pylori eradication is expected to increase in Japan. However, the predictive markers for early GC detected after H. pylori eradication have not been extensively studied. We conducted a retrospective, single-center observational study to investigate the predictive markers for early GC detected after H. pylori eradiation. METHODS: A total of 421 patients underwent endoscopic submucosal dissection for early GC at NTT West Osaka Hospital between June 2006 and August 2017...
November 19, 2018: Internal Medicine
Hao-Ran Fang, Guo-Qiang Zhang, Jing-Yi Cheng, Zhong-Yue Li
Therapy-related side effects and severe antimicrobial resistance still remain an obstacle to Helicobacter pylori eradication. This meta-analysis aimed to investigate the efficacy of Lactobacillus-supplemented triple therapy on H. pylori eradication rates and therapy-related side effects in children. Five studies involving 484 pediatric patients were included in our analysis. The pooled relative risk (RR) for eradication rates in the Lactobacillus group versus the control group was 1.19 [95% confidence interval (CI) 1...
November 16, 2018: European Journal of Pediatrics
Ludmila A Gerlinskaya, Ekaterina A Litvinova, Galina V Kontsevaya, Natalia A Feofanova, Ksenia M Achasova, Margarita V Anisimova, Svetlana O Maslennikova, Maria A Zolotykh, Yuri M Moshkin, Mikhail P Moshkin
STUDY QUESTION: Does the genotype of the surrogate mother modulate the body composition and immunity of her offspring? SUMMARY ANSWER: C57BL/6J (B6) progenies carried by immunodeficient NOD SCID (NS) mothers had increased adaptive, but decreased innate, immune responsiveness in comparison with the same genotype offspring carried by immunocompetent mothers, B6 and BALB/c (C); the B6 progenies carried by the same genotype mothers also showed higher body fat than the others...
November 16, 2018: Molecular Human Reproduction
Fahimeh Anbari, Anahita Ashouri Moghaddam, Elham Sabeti, Azin Khodabakhshi
INTRODUCTION: Halitosis is a common complaint among people which has various socioeconomic effects. The prevalence of halitosis includes a variety of 22% up to 50% in different societies. According to studies, there have been reports of remarkable improvements in halitosis after Helicobacter pylori eradication treatment. In studies on the relationship between H. Pylori and halitosis, the role of oral factors as the most important cause of halitosis has been neglected. This study was conducted with the aim of investigating the effect of oral factors on halitosis in patients with H...
November 15, 2018: Helicobacter
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