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https://www.readbyqxmd.com/read/30334829/clinical-insignficance-of-monoclonal-t-cell-populations-and-duodenal-intraepithelial-t-cell-phenotypes-in-celiac-and-nonceliac-patients
#1
Romulo Celli, Pei Hui, Hannah Triscott, Sidney Bogardus, Joanna Gibson, Michael Hwang, Marie E Robert
Refractory celiac disease (RCD) is a rare condition, usually managed at specialized centers. However, gastroenterologists and pathologists in general practices are often the first to consider a diagnosis of RCD in celiac patients with persistent symptoms. The distinction between type I and type II RCD is crucial as patients with RCD II have a shortened life expectancy. The diagnosis of RCD II requires the demonstration of abnormal intraepithelial lymphocytes and/or monoclonal T-cell populations in duodenal biopsies, typically assessed in formalin-fixed paraffin-embedded tissue...
October 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30332428/trends-in-the-seroprevalence-of-helicobacter-pylori-infection-and-its-putative-eradication-rate-over-18-years-in-korea-a-cross-sectional-nationwide-multicenter-study
#2
Seon Hee Lim, Nayoung Kim, Jin Won Kwon, Sung Eun Kim, Gwang Ho Baik, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Hyun Joo Song, Dae-Seong Myung, Suck Chei Choi, Hyun Jin Kim, Jeong Yoon Yim, Joo Sung Kim
The aims of this study were to demonstrate the trends in seropositivity and the eradication therapy rate for Helicobacter pylori (H. pylori) over an 18-year period in an asymptomatic Korean population and to explore the factors associated with H. pylori seropositivity and its eradication therapy. In total, 23,770 subjects (aged 17-97 years) from a health examination center participated in this cross-sectional study from January 2016 to June 2017. Questionnaires that included questions about the participants' H...
2018: PloS One
https://www.readbyqxmd.com/read/30329127/metformin-use-and-gastric-cancer-risk-in-diabetic-patients-after-helicobacter-pylori-eradication
#3
Ka Shing Cheung, Esther W Chan, Angel Y S Wong, Lijia Chen, Wai Kay Seto, Ian C K Wong, Wai K Leung
Background: Although prior studies showed metformin could reduce gastric cancer (GC) risk in patients with diabetes mellitus, they failed to adjust for Helicobacter pylori infection and glycemic control. We aimed to investigate whether metformin reduced GC risk in H. pylori-eradicated diabetic patients and its association with glycemic control. Methods: This was a territory-wide cohort study using hospital registry database, recruiting all diabetic patients who were prescribed clarithromycin-based triple therapy for H...
October 16, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30327875/sequential-h-pylori-eradication-and-radiation-therapy-with-reduced-dose-compared-to-standard-dose-for-gastric-malt-lymphoma-stages-ie-ii1e-a-prospective-randomized-trial
#4
Renate Schmelz, Stephan Miehlke, Christian Thiede, Stefan Brueckner, Monic Dawel, Matthias Kuhn, Agnes Ruskoné-Formestraux, Manfred Stolte, Christina Jentsch, Jochen Hampe, Andrea Morgner
BACKGROUND: In Helicobacter pylori (H. pylori) positive stage I gastric low-grade MALT lymphoma, eradication is the accepted first-line therapy. The role of eradication therapy in lymphoma > stage IE is still unclear. However, about 20% of patients show persistent lymphoma following successful eradication or primary H. pylori-negative lymphoma. A prospective study for salvage radiation therapy with standard 36 Gy in comparison to a reduced dose of 25.2 Gy is still missing. METHODS: A prospective, multicentre study investigated the efficacy of eradication in H...
October 16, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/30324767/successful-helicobacter-pylori-eradication-therapy-improves-symptoms-of-chronic-constipation
#5
Masaki Murata, Mitsushige Sugimoto, Taketo Otsuka, Atsushi Nishida, Osamu Inatomi, Shigeki Bamba, Akira Andoh
BACKGROUNDS AND AIMS: Constipation is one of the most common gastrointestinal functional disorders. Recently, the gut microbiota has been implicated in the development of constipation. Helicobacter pylori infection is considered to be a possible factor influencing the gut microbiota profile. Here, we investigated the effect of H. pylori eradication therapy on symptoms of chronic constipation. METHODS: We recruited 166 H pylori-positive patients who underwent eradication therapy after endoscopy...
October 15, 2018: Helicobacter
https://www.readbyqxmd.com/read/30324756/dynamics-of-antimicrobial-resistance-of-helicobacter-pylori-isolates-in-the-smolensk-region-of-russian-federation
#6
Natalia Dekhnich, Natalie Ivanchik, Roman Kozlov, Alexander Alimov, Andrey Steshits, Pavel Kirsov, Krunal Pandav
BACKGROUND: Efficacy of Helicobacter pylori eradication therapy depends on the chance of having a resistant H. pylori strain, which is ultimately related to the local antimicrobial resistance epidemiology. AIM: To assess H. pylori resistance to clarithromycin, amoxicillin, metronidazole, levofloxacin, and tetracycline in adult patients in the Smolensk region of Russian Federation over a 9-year period. MATERIALS AND METHODS: Biopsy samples were taken from the gastric antrum and body of 573 and 210 patients with dyspepsia symptoms and positive rapid urease test during esophagogastroduodenoscopy in 2015-2017 and 2009-2010, respectively...
October 16, 2018: Helicobacter
https://www.readbyqxmd.com/read/30323363/presence-of-pre-diabetes-in-helicobacter-pylori-positive-versus-helicobacter-pylori-negative-patients-having-dyspepsia
#7
Umar Draz, Rabia Rathore, Nasir Farooq Butt, Fawad Ahmad Randhawa, Uzma Malik, Tariq Waseem
Pre-diabetes is a state of intermediate hyperglycaemia. Helicobacter (H) pylori infection is an established risk factor for pre-diabetes. This comparative cross-sectional study was done in Mayo Hospital Lahore from November 2015 to August 2016 in which 270 patients underwent upper gastrointestinal endoscopy with antral biopsy. An oral glucose tolerance test was done half to one hour after endoscopy. Patients were diagnosed having pre-diabetes according to American Diabetic Association criteria. Cases were divided into Group A and B based on the presence or absence of histopathological evidence of H...
June 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30318949/helicobacter-pylori-and-chlamydia-trachomatis-in-sudanese-women-with-preeclampsia
#8
Mohamed A Ahmed, Nada G Hassan, Mai E Omer, Ali Rostami, Duria A Rayis, Ishag Adam
BACKGROUND: Helicobacter pylori  and Chlamydia trachomatis  infections are associated with many complications of pregnancy including preeclampsia. The association between H. pylori and C. trachomatis  with preeclampsia needs to be further explored. METHODS: A case- control study was conducted at Saad Abualila Hospital, Khartoum, Sudan during the period of February to August 2015 to investigate the association between H. pylori or C. trachomatis with preeclampsia...
October 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30317253/efficacy-of-standard-triple-therapy-versus-levofloxacin-based-alternate-therapy-against-helicobacter-pylori-infection
#9
Shahzad Latif, Noreen Akther, Sameen Amjed, Junaid Jafar, Bushra Saleem, Muhammad Usman, Tuaha Amjad, Waqas Maqsood, Humaira Waseem, Naim Ashraf
OBJECTIVE: To assess the effectiveness of clarithromycin based standard triple therapy verses levofloxacin based first line therapy against Helicobacter pylori infection. METHODS: This prospective observational study was performed at Akhter Saeed Trust Teaching Hospital, Lahore, from May 2016 to 31st May 2017 and comprised of all patients with positive H. pylori, confirmed by gastroscopic biopsy; fulfill the inclusion criteria of this study. Patients were divided into two groups (Group A and Group B)...
September 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30315306/grading-of-atrophic-gastritis-is-useful-for-risk-stratification-in-endoscopic-screening-for-gastric-cancer
#10
Kyosuke Kaji, Atsushi Hashiba, Chika Uotani, Yasushi Yamaguchi, Toshio Ueno, Kenji Ohno, Ichiro Takabatake, Tokio Wakabayashi, Hisashi Doyama, Itasu Ninomiya, Masato Kiriyama, Shigekazu Ohyama, Manabu Yoneshima, Nobu Koyama, Yasuo Takeda, Kenji Yasuda
OBJECTIVES: In order to screen for gastric cancer effectively, its interval should be set according to the risk. This study aimed to determine whether risk stratification is possible using the data obtained from medical examination or endoscopic findings. METHODS: First, subjects who underwent both cancer screening and medical examination from 2009 to 2015 and underwent cancer screening once more by 2016 were studied. Data such as the lipid profile and history of smoking obtained during the medical examination, and the grade of atrophy and presence of peptic ulcers were studied using multivariate analysis...
October 12, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/30313042/the-relationship-between-adenoid-hypertrophy-and-gastroesophageal-reflux-disease-a-meta-analysis
#11
Xun Niu, Zeng-Hong Wu, Xi-Yue Xiao, Xiong Chen
BACKGROUND: Gastroesophageal reflux disease (GERD) is believed to be associated with various manifestations in the otorhinolaryngology and has been found to be an additional risk factor for adenoid hypertrophy, but the causal relation between them is under controversial. We thus performed a meta-analysis to grade the strength of evidence and systematically explore whether adenoid hypertrophy correlates with GERD in the literature. METHODS: A systematic literature search was performed using Medline via PubMed, Embase, CNKI, and Web of Science...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30308319/h-pylori-and-parkinson-s-disease-meta-analyses-including-clinical-severity
#12
REVIEW
Efthimios Dardiotis, Zisis Tsouris, Alexios-Fotios A Mentis, Vasileios Siokas, Amalia Michalopoulou, Maria Sokratous, Metaxia Dastamani, Dimitrios P Bogdanos, Georgia Deretzi, Jannis Kountouras
The exact etiology of Parkinson's disease (PD) remains unclear. Some evidence supports Helicobacter pylori infection as a trigger or driving event, but detection and eradication of H. pylori are not part of PD management. The aims of this case-control study and meta-analysis were to determine (i) the prevalence of H. pylori infection in PD patients, (ii) associations between H. pylori infection and clinical status, and (iii) differences in motor status in PD patients before and after H. pylori eradication. A literature search was performed using the PubMed database...
October 1, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30306734/role-of-serum-ebv-vca-igg-detection-in-assessing-gastric-cancer-risk-and-prognosis-in-northern-chinese-population
#13
Zeyang Wang, Zhi Lv, Hanxi Ding, Qian Xu, Liping Sun, Jingjing Jing, Yuan Yuan
The study aimed to investigate the role of serum EBV-VCA IgG in assessing gastric cancer (GC) risk and prognosis. A total of 1790 Northern Chinese participants with pathologically confirmed disease underwent EBV-VCA IgG serologic testing using enzyme-linked immunosorbent assay (ELISA), including 821 controls, 410 atrophic gastritis (AG) patients, and 559 GC patients. We found that positive EBV-VCA IgG was significantly associated with GC and its precursor, conferring a 1.55- and 1.36-fold increased risk of GC and AG, respectively (P = 0...
October 10, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30302246/prevalence-of-helicobacter-pylori-in-asymptomatic-patients-at-surgical-outpatient-department-harare-hospitals
#14
Simbarashe Gift Mungazi, Onesai Blessing Chihaka, Godfrey I Muguti
Background: Helicobacter pylori infection is present in more than 50% of the world's population. The estimated life time risk of peptic ulcer disease is 20 percent and of gastric cancer is 1-2 percent. Materials and methods: A cross sectional study was done at two Central hospitals in Harare, Zimbabwe, with the objective being to estimate the prevalence of Helicobacter pylori infection in asymptomatic individuals. Other objectives were to determine the association of the Helicobacter pylori infection with potential risk factors...
November 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30302165/therapeutic-efficacy-of-amoxicillin-and-rifaximin-in-patients-with-small-intestinal-bacterial-overgrowth-and-helicobacter-pylori-infection
#15
Paulina Konrad, Jan Chojnacki, Anita Gąsiorowska, Cezary Rudnicki, Aleksandra Kaczka, Cezary Chojnacki
Introduction: Small intestinal bacterial overgrowth (SIBO) may coexist with Helicobacter pylori infection, which can be the cause of chronic gastrointestinal complaints. Aim: Evaluation of the therapeutic efficacy of amoxicillin and rifaximin in the treatment of these diseases. Material and methods: The lactulose hydrogen breath test (LHBT) and the urea breath test (13 C-UBT) were performed in 116 patients. In 62 patients the coexistence of small intestinal bacterial overgrowth and H...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/30301709/toll-like-receptor-2-and-4-polymorphisms-associated-with-helicobacter-pylori-susceptibility-and-gastric-cancer
#16
Taweesak Tongtawee, Theeraya Simawaranon, Wareeporn Wattanawongdon, Chavaboon Dechsukhum, Wilairat Leeanansaksiri
BACKGROUND/AIMS: Genetic polymorphisms in Toll-like receptors (TLRs) are important influence on gastric lesion development and Helicobacter pylori susceptibility. MATERIALS AND METHODS: TLR2 rs3804099 and rs3804100 and TLR4 rs10759932 were determined in a total of 400 patients. The association among genotypes and the risk of gastric lesion development and H. pylori susceptibility were evaluated by the odds ratios (ORs) and 95% confidence intervals (95% CIs) from logistic regression analyses...
October 9, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/30301329/seven-days-triple-therapy-for-eradication-of-helicobacter-pylori-does-not-alter-the-disease-activity-of-patients-with-inflammatory-bowel-disease
#17
Shinichiro Shinzaki, Toshimitsu Fujii, Shigeki Bamba, Maiko Ogawa, Taku Kobayashi, Masahide Oshita, Hiroki Tanaka, Keiji Ozeki, Sakuma Takahashi, Hiroki Kitamoto, Kazuhito Kani, Sohachi Nanjo, Takeshi Sugaya, Yuko Sakakibara, Toshihiro Inokuchi, Kazuki Kakimoto, Akihiro Yamada, Hisae Yasuhara, Yoko Yokoyama, Takuya Yoshino, Akira Matsui, Misaki Nakamura, Taku Tomizawa, Ryosuke Sakemi, Noriko Kamata, Toshifumi Hibi
Background/Aims: The influences of Helicobacter pylori eradication therapy on the disease course of inflammatory bowel disease (IBD) are still unclear. We therefore conducted a multicenter, retrospective cohort study to evaluate the safety of H. pylori eradication therapy for IBD patients. Methods: IBD patients with H. pylori eradication from 2005 to 2015 (eradication group) and control patients (non-eradication group; 2 paired IBD patients without H. pylori eradication matched with each eradicated patient) were included...
October 10, 2018: Intestinal Research
https://www.readbyqxmd.com/read/30296434/serological-response-to-helicobacter-pylori-proteins-associate-with-risk-of-colorectal-cancer-among-diverse-populations-in-the-united-states
#18
Julia Butt, Matthew G Varga, William J Blot, Lauren Teras, Kala Visvanathan, Loïc Le Marchand, Christopher Haiman, Yu Chen, Ying Bao, Howard D Sesso, Sylvia Wassertheil-Smoller, Gloria Y F Ho, Lesley E Tinker, Richard M Peek, John D Potter, Timothy L Cover, Laura H Hendrix, Li-Ching Huang, Terry Hyslop, Caroline Um, Francine Grodstein, Mingyang Song, Anne Zeleniuch-Jacquotte, Sonja Berndt, Allan Hildesheim, Tim Waterboer, Michael Pawlita, Meira Epplein
BACKGROUND & AIMS: Previous studies reported an association of the bacteria Helicobacter pylori, the primary cause of gastric cancer, and risk of colorectal cancer (CRC). However, these findings have been inconsistent, appear to vary with population characteristics, and may be specific for virulence factor VacA. To more thoroughly evaluate the potential association of H pylori antibodies with CRC risk, we assembled a large consortium of cohorts representing diverse populations in the United States...
October 5, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30294347/high-seroprevalence-of-anti-helicobacter-pylori-antibodies-in-patients-with-ventilator-associated-pneumonia
#19
Alireza Dadashi, Nima Hosseinzadeh
Background: The pathogenesis of ventilator-associated pneumonia (VAP) is not clearly known. Recently, the role of gastric bacterial colonization has been proposed. The role of gastric colonization with Helicobacter pylori in pathogenesis of VAP was determined by comparing the prevalence of H. pylori in patients with VAP and control participants. Materials and Methods: One hundred and eighteen mechanically ventilated patients were divided into two groups; 59 participants with VAP and 59 without VAP...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30293417/prevalence-of-helicobacter-pylori-infection-among-dyspeptic-patients-with-and-without-type-2-diabetes-mellitus-in-south-west-and-south-south-regions-of-nigeria
#20
Stella I Smith, Tolulope Jolaiya, Charles Onyekwere, Muinah Fowora, Rose Ugiagbe, Ifeanyi Agbo, Cara Cookey, Olufunmilayo Lesi, Dennis Ndububa, Olusegun Adekanle, Pia Palamides, Isaac Adeleye, Henry Njom, Idowu Ayodeji, Anna Clarke, Rinaldo Pellicano
BACKGROUND: This multicenter study was undertaken to determine the prevalence of Helicobacter pylori (H. pylori) infection among dyspeptic patients with and without type 2 diabetes mellitus (T2DM). METHODS: Patients with dyspepsia were recruited from tertiary teaching hospitals, three in the South-West and one in the South-South regions of Nigeria, between November 2016 and August 2017. The participants had breath samples analyzed for H. pylori by the Urea Breath Test (UBT) following manufacturer's instructions...
October 2, 2018: Minerva Gastroenterologica e Dietologica
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