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https://www.readbyqxmd.com/read/30334470/understanding-the-elusive-protein-corona-of-thermoresponsive-nanogels
#1
Enrico Miceli, Benno Kuropka, Christine Rosenauer, Ernesto R Osorio Blanco, Loryn E Theune, Mrityunjoy Kar, Christoph Weise, Svenja Morsbach, Christian Freund, Marcelo Calderón
AIM: We analyzed the protein corona of thermoresponsive, poly(N-isopropylacrylamide)- or poly(N-isopropylmethacrylamide)-based nanogels. MATERIALS & METHODS: Traces of protein corona detected after incubation in human serum were characterized by proteomics and dynamic light scattering in undiluted serum. RESULTS: Apolipoprotein B-100 and albumin were the main components of the protein coronae. For dendritic polyglycerol-poly(N-isopropylacrylamide) nanogels at 37°C, an increase in adsorbed immunoglobulin light chains was detected, followed by partially reversible nanogel aggregation...
October 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30318226/redox-responsive-hyaluronic-acid-nanogels-for-hyperthermia-assisted-chemotherapy-to-overcome-multidrug-resistance
#2
Bangbang Li, Qinan Xu, Xinfang Li, Peng Zhang, Xiao Zhao, Youxiang Wang
Although chemotherapy has been widely used in the treatment of many kinds of cancer, drug resistance and side effects are the main obstacles in the cancer chemotherapy that result in an inferior therapeutic outcome. For the design of drug delivery system, extracellular stability and intracellular effective release are also a pair of contradictions. In this research, gold nanorods (AuNRs) loaded hyaluronic acid (HA) nanogels with reduction sensitivity were prepared for the efficient intracellular delivery of doxorubicin (DOX)...
January 1, 2019: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30318224/smart-nanocarrier-based-on-pegylated-hyaluronic-acid-for-deacetyl-mycoepoxydience-high-stability-with-enhanced-bioavailability-and-efficiency
#3
Juan Zhao, Yancai Wang, Yingying Ma, Yangyang Liu, Beibei Yan, Lulu Wang
Deacetyl mycoepoxydience (DM) nanocrystals core were stabilized by the folate modified distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG2000 -FA) as the active-targeting stabilizer and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) as the reversion of multidrug resistance stabilizer, respectively. The DM nanocrystals was acted as the core and shelled by the polyethylene glycol-hyaluronic acid (PEG-HA). The optimal core-shell system demonstrated superior stability at 4 °C for 6 weeks by the stability study and higher dissolution velocity...
January 1, 2019: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30308085/highly-efficient-synthesis-and-assay-of-protein-imprinted-nanogels-using-magnetic-templates
#4
Rashmi Mahajan, Mona Rouhi, Sudhirkumar Shinde, Thomas Bedwell, Anil Incel, Liliia Mavliutova, Sergey Piletsky, Ian Nicholls, Börje K-E Sellergren
We here report an approach integrating synthesis and a highly sensitive as-say of protein imprinted nanogels ("plastic antibodies") employing templates attached to magnetic carriers. The proteolytic enzymes trypsin and pepsin were immobilized on aminofunctionalized solgel coated magnetic nanoparticles (magNPs). Lightly crosslinked fluorescently doped polyacrylamide nanogels were subsequently produced by high dilution polymerization of monomers in presence of 50 mg of the magNPs. This was followed by multiple washes of the magnetically trapped particles and collection of each fraction...
October 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30306054/responsive-alginate-cisplatin-nanogels-for-selective-imaging-and-combined-chemo-radio-therapy-of-proliferating-macrophages
#5
Suk Ho Hong, Yan Li, Joo Beom Eom, Yongdoo Choi
Background: Atherosclerosis is a major global health concern. Targeting macrophages is hypothesized as an alternative treatment for atherosclerosis. Methods: We synthesized alginate-based cisplatin-loaded nanogels (TANgel) as a pH-responsive drug-releasing theranostic nanoplatform for macrophage cells. Carboxylic acid groups of alginic acid were modified with iminodiacetic acid (IDA) to enhance chelation of platinum ions. The near infrared (NIR) fluorophore ATTO655 was conjugated to the modified alginic acid...
September 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/30300550/a-new-strategy-for-intestinal-drug-delivery-via-ph-responsive-and-membrane-active-nanogels
#6
Shiqi Wang, Youlim Ha, Xiaozhen Huang, Benjamin Chin, Wen Sim, Rongjun Chen
Oral administration of hydrophobic and poorly intestinal epithelium-permeable drugs is a significant challenge. Herein, we report a new strategy to overcome this problem by using novel, pH-responsive and membrane-active nanogels as drug carriers. Prepared by simple physical crosslinking of amphiphilic pseudopeptidic polymers with pH-controlled membrane-activity, the size and hydrophobicity-hydrophilicity balance of the nanogels could be well tuned. Furthermore, the amphiphilic nanogels could release hydrophobic payloads and destabilise cell membranes at duodenum and jejunum pH 5...
October 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30287044/hyaluronic-acid-based-nanocrystals-hydrogels-for-enhanced-topical-delivery-of-drug-a-case-study
#7
Shaofeng Wei, Jin Xie, Yijing Luo, Yueqin Ma, Shunxi Tang, Pengfei Yue, Ming Yang
The objective of this study is to use a carbohydrate polymer hyaluronic acid (HLA) as matrix to design novel transdermal nanogel loading poorly soluble drug nanocrystals. Baicalin nanocrystals (BCA-NC) were prepared by coupling homogenization technology and spray-drying technology. The morphology, the rheological behavior and transdermal permeation studies of HLA based BCA-NC-gel were evaluated. The results demonstrated that the BCA-NC could be successfully prepared in terms of trehalose after spray-drying...
December 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30285546/molecular-self-assembly-of-copolymer-from-renewable-phenols-new-class-of-antimicrobial-ointment-base
#8
Denial Mahata, Santi M Mandal
Ointments are highly viscous forms intended for external applications either medicated or non-medicated means. Formulation of ointment depends upon the base ingredients to measure the viscosity difference. Several limitations of ointment bases has been encountered timely as agglomeration, oil phase ingredients can form lumps, poor dispersion, poor drug delivery efficiency, make stained, immiscible, and difficult to wash off. Therefore, it is necessary to make a new type of ointment bases that can overcome those limitations...
October 4, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/30277228/subtle-changes-in-network-composition-impact-the-biodistribution-and-tumor-accumulation-of-nanogels
#9
Ilona Zilkowski, Ioanna Theodorou, Krystyna Albrecht, Frederic Ducongé, Jürgen Groll
We studied the effect of subtle changes in side-chain chemistry and labelling with near infrared fluorophores of nanogels (NGs) prepared from thiolated poly(glycidol) on in vivo biodistribution in mice bearing human breast tumor xenografts. The stability and amphiphilic character of the side chain as well as labelling clearly influenced tumor targeting and overall biodistribution.
October 16, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30261137/a-novel-membrane-detector-based-on-smart-nanogels-for-ultrasensitive-detection-of-trace-threat-substances
#10
Pei-Jie Yan, Fan He, Wei Wang, Shi-Yuan Zhang, Lei Zhang, Ming Li, Zhuang Liu, Xiao-Jie Ju, Rui Xie, Liang-Yin Chu
A novel membrane detector is developed by a facile strategy combining commercialized membrane and smart nanogels, for ultrasensitive and highly-selective real-time detection of trace threat substances. Based on nanogel filtration and polydopamine adhesion, the membrane detector is fabricated by simply immobilizing smart nanogels onto the multiple pores of a commercialized membrane as the nanosensors and nanovalves. This is demonstrated by incorporating Pb2+-responsive poly(N-isopropylacrylamide-co-acryloylamidobenzo-18-crown-6) nanogels in the straight pores of a commercialized polycarbonate membrane for ultrasensitive and highly-selective real-time detection of trace Pb2+...
September 27, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30241856/one-pot-fabrication-of-ph-reduction-dual-stimuli-responsive-chitosan-based-supramolecular-nanogels-for-leakage-free-tumor-specific-dox-delivery-with-enhanced-anti-cancer-efficacy
#11
Jiagen Li, Peng Liu
Facile one-pot approach was established to fabricate chitosan-based supramolecular nanogels as pH/reduction dual-stimuli responsive drug delivery system (DDS) for anticancer drug (doxorubicin, DOX), by bioreducible crosslinking of the β-cyclodextrin modified chitosan (CD-CS) with disulfide bond embedded crosslinker (Ad-SS-Ad) via host-guest inclusion and simultaneous DOX loading. The DOX@Ad-SS-Ad/CD-CS supramolecular nanogels with hydrodynamic diameter (Dh ) of 140 nm and drug-loading capacity of 15.9% were obtained with the mass feeding ratio of carrier:DOX at 25:10...
December 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30240152/protein-nanotherapeutics-as-an-emerging-modality-for-cancer-therapy
#12
REVIEW
Liang Cheng, Liang Yang, Fenghua Meng, Zhiyuan Zhong
Protein drugs are a unique and versatile class of biotherapeutics that have not only high biological activity but also superb specificity. This rapidly evolving biotechnology has rendered it possible to produce various proteins in a large scale and reproducible way. Many proteins have demonstrated striking anticancer activities and have emerged as advanced alternatives to cytotoxic chemotherapeutic agents for cancer therapy. The clinical translation of anticancer proteins with intracellular targets is, nevertheless, severely hindered by their fast degradation in vivo, poor cell penetration, and inefficient intracellular transportation...
September 21, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30221496/nanogel-tectonics-for-tissue-engineering-protein-delivery-systems-with-nanogel-chaperones
#13
REVIEW
Yoshihide Hashimoto, Sada-Atsu Mukai, Yoshihiro Sasaki, Kazunari Akiyoshi
Amphiphilic polysaccharide self-assembled (SA) nanogels are promising protein carriers owing to their chaperone-like activity that allows them to nanoencapsulate proteins within their polymer networks. The chaperoning function is an important concept that has led to breakthroughs in the development of effective protein drug delivery systems by stabilizing formulations and controlling the quality of unstable proteins. Recently, nanogel-tectonic materials that integrate SA nanogels as building blocks have been designed as new hydrogel biomaterials...
September 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30196141/lipid-bilayer-coated-nanogels-allow-for-sustained-release-and-enhanced-internalization
#14
Chao Qin, Yaqi Lv, Chaoran Xu, Jingjing Li, Lifang Yin, Wei He
Nanoparticle drug delivery system improves the therapeutic efficacy of a drug; however, achieving sustained release from nanoparticles is challenging, owing to the increase of surface area and pronounced burst release. In this study, by incorporating an organogel of 12-hydroxystearic acid (12-HSA) into lipid-bilayers, a gel-liposomal formulation was developed to sustain drug release over time. The lipid-bilayer-coated nanogels (LBCNs) with a particle size of approximately 200 nm and with a core-shell structure had an entrapment efficiency of up to 80% for paclitaxel...
November 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30184803/reduction-sensitive-polypeptide-nanogel-conjugated-bodipy-br-for-nir-imaging-guided-chem-photodynamic-therapy-at-low-light-and-drug-dose
#15
Le Liu, Tuanwei Li, Zheng Ruan, Pan Yuan, Lifeng Yan
A heavy atoms modified reaction-active photosensitizer NHS-BODIPY-Br possessing efficient near infrared (NIR) fluorescence emission and singlet oxygen generation properties has been synthesized, which can be used for synchronous NIR imaging and photodynamic therapy (PDT). A reduction-sensitive PEGylated polypeptide nanogel was prepared by ring-opening polymerization (ROP) of l-cystine-N-carboxy anhydride. Poly (ethylene glycol) methyl ether was used as initiator and hydrophilic segment, the as-prepared nanogel was conjugated with the NHS-BODIPY-Br molecule by chemical linkage, and it can be directly used as a macrophotosentizer for NIR imaging-guided PDT...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30184786/a-novel-multi-stimuli-responsive-pegylated-hybrid-gold-nanogels-for-co-delivery-of-doxorubicin-and-6%C3%A2-mercaptopurine
#16
Marjan Ghorbani, Hamed Hamishehkar
The clinical applications of anticancer drugs are restricted due to the incomplete delivery to the cancerous tissue and the numerous drug resistance mechanisms involved in malignant cells. In this regard, stimuli-responsive nanomaterials offer a promising prospect to deal with these concerns. In the present study, ternary responsive hybrid gold/nanogels (Au/NGs) were synthesized as a new nanoplatform to simultaneously carry two anticancer drugs, i.e., doxorubicin (DOX) and 6-mercaptopurine (MP). For this purpose, these drugs were successfully loaded (the loading capacity of 23% and 11%, respectively) into the hybrid Au/NGs by electrostatic interaction (DOX) and AuS bonds (MP)...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30179013/externally-triggered-oscillatory-structural-forces
#17
Sebastian Schön, Marcel Richter, Marcus Witt, Regine von Klitzing
This paper addresses triggering of oscillatory structural forces via temperature variation across an aqueous dispersion of thermoresponsive poly( N-isopropylacrylamide) (PNIPAM) nanogels confined between silica surfaces. Oscillatory structural forces are a well-known phenomenon in colloidal science, caused by interactions between molecules or colloids. Modulation of these forces usually requires changing the internal parameters of the dispersion, such as ionic strength, particle concentration, and surface charge, or changing the properties of the confining walls, such as surface roughness, potential, or elasticity...
September 25, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30168150/on-electrophoresis-of-a-ph-regulated-nanogel-with-ion-partitioning-effects
#18
P S Majee, Somnath Bhattacharyya, Prashanta Dutta
The electrophoresis of a polyelectrolyte nanoparticle, whose charge condition depends on the salt concentration and pH of the suspended medium as well as the dielectric permittivity difference, is analyzed. The present nonlinear model for the electrophoresis of this pH-regulated polyelectrolyte (PE) particle is based on the consideration of full set of governing equations of fluid and ion transport coupled with the equation for electric field. The Born energy of the ions are incorporated to account for the difference in the dielectric permittivity of the PE and the electrolyte...
August 31, 2018: Electrophoresis
https://www.readbyqxmd.com/read/30165144/alginate-hydrogel-beads-as-a-carrier-of-low-density-lipoprotein-pectin-nanogels-for-potential-oral-delivery-applications
#19
Mingyong Zhou, Qiaobin Hu, Taoran Wang, Jingyi Xue, Yangchao Luo
Alginate hydrogel beads have been extensively investigated as drug delivery systems due to promising gastric environment stability. In the present study, alginate hydrogel beads were prepared with Ca2+ or Fe3+ to serve as the loading vehicles for egg yolk low density lipoprotein (LDL)/pectin nanogels. Scanning electron microscope was carried out to confirm the successful incorporation of nanogels into the beads. The FT-IR spectra and swelling ratio analyses proved that incorporation of nanogels did not affect the physicochemical properties of the hydrogel beads...
December 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30153460/synthesis-and-characterization-of-schizophyllan-nanogels-via-inverse-emulsion-using-biobased-materials
#20
Sahar Mousaviasl, Tayebeh Saleh, Seyed Abbas Shojaosadati, Soheil Boddohi
Oxidized sucrose cross-linked Schizophyllan nanogel was successfully synthesized via inverse emulsion method for the first time. The synthesis process was conducted in the absence of both toxic cross-linker and organic solvent. The nanogel crosslinking network was prepared using fractionated coconut oil as the continuous phase and oxidized sucrose as the cross-linker. The formation of ether linkage on schizophyllan cross-linked structure was confirmed by Fourier transform infrared microscopy (FTIR) analysis...
December 2018: International Journal of Biological Macromolecules
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