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Leila Pourtalebi Jahromi, Fatemeh Moghaddam Panah, Amir Azadi, Hajar Ashrafi
Chitosan-based hydrogel nanoparticles provide a higher brain concentration of methotrexate (MTX) following IV administration in comparison with the drug's simple solution. The present study investigates the mechanism of this phenomenon, focusing on the possible role of P-gp. A previously developed MTX containing chitosan nanogel was fabricated and characterised. Then 48 rats were divided into four groups: two receiving nanogels and two receiving solution of MTX, while 1 of each two had received a verapamil dose 30 min before MTX...
December 10, 2018: International Journal of Biological Macromolecules
Oyawale Adetunji Moses, Malik Ihsanullah Khan, Qi Fang, Liu Qin, Zia Ur Rehman, Youkui Zhang, Cao Deng Feng, Yinchu Ma, XinFeng Tang, Chuanqiang Wu, Mukhtar Lawan Adam, Dake Huang, Hang Liu, Li Song
Transition metal dichalogenides (TMDCs) with unique layered structures hold promising potential as transducers for photothermal therapy. However, the low photothermal conversion efficiency and poor stability in some cases limit their practical applications. Herein, we demonstrate the fabrication of ultrathin homogeneous hybridized TMDC nanosheets and their use for highly efficient photothermal tumor ablation. In particular, the nanosheets were composed of metallic WSe2 intercalated with polyvinylpyrrolidone (PVP), which was facilely prepared through a solvothermal process from the mixture of selenourea crystals, WCl6 powder along with PVP polymeric nanogel...
December 13, 2018: Nanotechnology
Se-Hee Lee, Ho-Joong Kim, Duck-Hyun Kim, Won-Seok Chang, Temmy Pegarro Vales, Jae-Woo Kim, Ki-Hong Kim, Jong-Ki Kim
The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100-250 nm) that are interconnected via multiple nano-channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)-carried thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanogel (30-50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug-loading and release in silicon- or polyethylene oxide-microemulsion BMCLs under various conditions. Nanoporous BMCLs containing thermosensitive TM-laden nanogel were capable of potent body-temperature-triggered release of TM...
December 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Seyyed Sohrab Rostamkalaei, Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Ali Nokhodchi
The aim of the present study was to enhance the skin delivery of metformin by making solid lipid nanoparticles containing metformin using the ultra-sonication method. To achieve the optimum skin delivery for metformin, the effects of the ratio of two surfactants (Tween:Span) on nanoparticles properties and their performance were investigated. Photon correlation spectroscopy, scanning electron microscopy (SEM), Powder X-ray Diffractometer (PXRD), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) were used to characterize the solid state of metformin in solid lipid nanoparticles...
November 28, 2018: Colloids and Surfaces. B, Biointerfaces
Bei Cheng, Feng Gao, Erica Maissy, Peisheng Xu
Suramin (SM), a drug for African sleeping sickness and river blindness therapy, has been investigated in various clinical trials for cancer therapy. However, SM was eventually withdrawn from the market because of its narrow therapeutic window and the side effects associated with multiple targets. In this work, we developed a simple but effective system based on a nontoxic dose of SM combined with a chemotherapeutic agent for the treatment of metastatic triple-negative breast cancer (TNBC). SM and glycol chitosan (GCS) formed nanogels because of the electrostatic effect, whereas doxorubicin (DOX) was incorporated into the system through the hydrophilic and hydrophobic interactions between DOX and GCS as well as the ionic interactions between DOX and SM to yield GCS-SM/DOX nanoparticles (NPs)...
December 5, 2018: Acta Biomaterialia
Niloy Chandra Sarker, Shafiqur Rahman, Md Saidul Borhan, Parthiban Rajasekaran, Swadeshmukul Santra, Ali Ozcan
A number of mitigation techniques exist to reduce the emissions of pollutant gases and greenhouse gases (GHGs) from anaerobic storage of livestock manure. Nanoparticle (NP) application is a promising mitigating treatment option for pollutant gases, but limited research is available on the mode of NP application and their effectiveness in gaseous emission reduction. In this study, zinc silica nanogel (ZnSNL), copper silica nanogel (CuSNL), and N-acetyl cysteine (NACL) coated zinc oxide quantum dot (Qdot) NPs were compared to a control lacking NPs...
February 2019: Journal of Environmental Sciences (China)
Samia M Omar, Nabila A Maziad, Nourhan M El-Tantawy
PURPOSE: Inhalable pulmonary delivery of isoniazid (INH) may improve the efficacy and reduce drug-resistant problem. METHOD: INH-loaded chitosan microparticles (Cs-Mps-1-3) were prepared as inhalable carrier for the previously prepared INH-loaded polyvinylpyrrolidone/polyitaconic acid nanoparticles (NPs) using spray-drying technique. Here, Cs-Mps-1-3 are composed of Cs: INH-loaded NPs: Free INH at w/w ratios (1:1:0), (1: 0:1), and (1:1:1), respectively. Subsequently, the prepared Cs-Mps-1-3 characterizations were studied...
December 8, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Grace Lu, Lisa Ann Holland
Glycosylated human IgG contains fucosylated biantennary N-glycans with different modifications including N-acetylglucosamine that bisects the mannose core. Although only a limited number of IgG N-glycan structures are possible, human IgG N-glycans are predominantly biantennary and fucosylated and contained varying levels of α2-6 linked sialic acid, galactose, and bisected N-acetylglucosamine. Monitoring the relative abundance of bisecting N-acetylglucosamine is relevant to physiological processes. A rapid, inexpensive, and automated method is used to successfully profile N-linked IgG glycans and is suitable to distinguish differences in bisection, galactosylation, and sialylation in N-glycans derived from different sources of human IgG...
December 9, 2018: Analytical Chemistry
Adetunji Moses Oyawale, Malik Ihsanullah Khan, Fang Qi, Qin Liu, Zia Ur Rehman, Youkui Zhang, Deng Feng Cao, Yinchu Ma, XinFeng Tang, Chuan Qiang Wu, Mukhtar Lawan Adam, Dake Huang, Hang Liu, Li Song
Transition metal dichalogenides (TMDCs) with unique layered structures hold promising potential as transducers for photothermal therapy. However, the low photothermal conversion efficiency and poor stability in some cases limit their practical applications. Herein, we demonstrate the fabrication of an ultrathin homogeneous hybridized TMDC nanosheets and their use for highly efficient photothermal tumor ablation. In particular, the nanosheets were composed of metallic WSe2 intercalated with polyvinylpyrrolidone (PVP), which was facilely prepared through a solvothermal process from the mixture of selenourea crystals, WCl6 powder along with PVP polymeric nanogel...
November 15, 2018: Nanotechnology
Xin Chen, Huailin Yang, Chunsheng Xiao, Xuesi Chen
Herein, a kind of fluorescent resveratrol nanogels via one-pot thiol-ene Michael addition polymerization of resveratrol triacrylate, 1,6-hexanedithiol, and methoxyl poly(ethylene glycol) acrylate is prepared. The resultant nanogels can be well-dispersed in water with a hydrodynamic radius of around 68 nm, and the nanogels are stable in both water and organic solvents. Moreover, the resveratrol nanogels exhibit elevated fluorescence intensity compared to free resveratrol, and the quantum yield of resveratrol nanogels is estimated to be 5...
December 5, 2018: Macromolecular Bioscience
Steffen Sydow, Dominik de Cassan, Robert Hänsch, Thomas R Gengenbach, Christopher D Easton, Helmut Thissen, Henning Menzel
Nanogels were prepared by ionotropic gelation of chitosan (CS) with tripolyphosphate (TPP). The use of such nanogels to prepare coatings by layer-by-layer deposition (LbL) was studied. The nanogels were characterized in terms of particle size, zeta-potential and stability. Nanogel suspensions were used to build polyelectrolyte multilayers on silicon wafers and on PCL fiber mats by LbL-deposition. Three different polysaccharides were used as polyanions, namely chondroitin sulfate, alginate and hyaluronic acid...
December 4, 2018: Biomaterials Science
Simona De Gregori, Manuela De Gregori, Nora Bloise, Dario Bugada, Mariadelfina Molinaro, Claudia Filisetti, Massimo Allegri, Michael E Schatman, Lorenzo Cobianchi
Background: The pharmacokinetic properties and clinical advantages of the local anesthetic chloroprocaine are well known. Here, we studied the pharmacokinetic profile of a new hydrogel device loaded with chloroprocaine to investigate the potential advantages of this new strategy for postoperative pain (POP) relief. Materials and methods: We performed both in vitro and in vivo analyses by considering plasma samples of four piglets receiving slow-release chloroprocaine...
2018: Journal of Pain Research
Agnieszka Gola, Monika Gasztych, Vanja Kokol, Aleksandra Malamis, Igor Mucha, Witold Musia
The present study evaluates the effect of the cationic initiator on the hydrodynamic diameter of copolymers of N -isopropylacrylamide nanogels synthesized via a surfactant-free precipitation polymerization at 70 °C in the presence of the cationic initiator 2,2'-azobis[2- methylpropionamidine] dihydrochloride. Three types of polymeric nanoparticles were synthesized using N, N '-methylenebisacrylamide as a crosslinker. The first batch was used as a reference. The second type of particles included a poly(ethylene glycol) methyl ether-acrylate monomer, while the third type used an N-tert -butylacrylamide comonomer...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Lei Zhang, Zhuang Liu, Lu-Yue Liu, Jun-Li Pan, Feng Luo, Chao Yang, Rui Xie, Xiao-Jie Ju, Wei Wang, Liang-Yin Chu
Thermo-responsive surfaces featured with nanostructures have found wide potential applications in biological and chemical fields. Herein, we report nanostructured thermo-responsive surfaces engi-neered via stable immobilization of thermo-responsive nanogels with assistance of polydopamine. The results show that the thin layer of polydopamine on the poly(N-isopropylacrylamide) (PNIPAM) nanogels nearly does not affect the thermo-responsive property of the nanogels. The stability of thermo-responsive nanogels on the substrate surfaces immobilized under different pH conditions of dopamine solutions are quatitively studied by fluid shearing experiments inside capil-laries, and the characterization results show that the strong interaction forces between the polydo-pamine layer on the substrate surfaces and the thermo-responsive nanogels are heavily depended on the oxidation state of dopamine molecules...
November 26, 2018: ACS Applied Materials & Interfaces
Hejin Shi, Yong Liu, Rui Qu, Yuanfeng Li, Rujiang Ma, Yingli An, Linqi Shi
Novel artificial enzymes are highly desired to overcome the shortcomings of natural enzymes during industrial or biological applications. Here we designed and prepared nanogel-based artificial enzymes (NAEs) to mimic natural horseradish peroxidase (HRP) using a facile one-pot, scalable method. The poly(N-isopropylacrylamide) (PNIPAM) matrix provided a temperature-responsive and size-controllable scaffold for the NAEs, and 1-vinylimidazole (Vim) moieties stabilized the enzymatic centers (Hemin) through coordination interaction...
November 10, 2018: Colloids and Surfaces. B, Biointerfaces
Prashant Sahu, Sushil K Kashaw, Samaresh Sau, Varun Kushwah, Sanyog Jain, Ram K Agrawal, Arun K Iyer
Combating melanoma via topical route is a highly challenging task due to low selectivity, poor efficacy and impeding biological environment of the skin. In the present study, we engineered a chitosan based pH responsive biodegradable nanogel (FCNGL), encapsulated with 5-FU that was effective even at very low drug doses (0.2% w/v) against melanoma. The FCNGL was synthesized by ion gelation technique exhibited nano-size particle distribution and sustained drug release kinetics. Hemolysis and coagulation analysis revealed high safety whereas MTT and apoptosis assays exhibited the efficacy of FCNGL...
November 10, 2018: Colloids and Surfaces. B, Biointerfaces
Sussana A Elkassih, Petra Kos, Hu Xiong, Daniel J Siegwart
Stimuli-responsive nanogels are important drug and gene carriers that mediate the controlled release of therapeutic molecules. Herein, we report the synthesis of fully degradable disulfide cross-linked nanogel drug carriers formed by oxidative radical polymerization of 2,2'-(ethylenedioxy)diethanethiol (EDDET) as a monomer with different cross-linkers, including pentaerythritol tetramercaptoacetate (PETMA). Because the poly(EDDET) backbone repeat structure and cross-linking junctions are composed entirely of disulfide bonds, these nanogels specifically degrade to small molecule dithiols intracellularly in response to the reducing agent glutathione present inside of cells...
November 21, 2018: Biomaterials Science
Nicolò Mauro, Cinzia Scialabba, Roberto Puleio, Paola Varvarà, Mariano Licciardi, Gennara Cavallaro, Gaetano Giammona
The extremely complex tumor microenvironment (TME) in humans is the major responsible for the therapeutic failure in cancer nanomedicine. A new concept of disease-driven nanomedicine, henceforth named "Theranomics", which attempts to target cancer cells and TME on the whole, represents an attractive alternative. Herein, a nanomedicine able to co-deliver doxorubicin and a tumor suppressive proteolytic protein such as collagenase-2 was developed. We successfully obtained superparamagnetic nanogels (SPIONs/Doco@Col) via the intermolecular azide-alkyne Huisgen cycloaddition...
November 17, 2018: International Journal of Pharmaceutics
Hao Yang, Qin Wang, Zifu Li, Fuying Li, Di Wu, Man Fan, Anbi Zheng, Bo Huang, Lu Gan, Yuliang Zhao, Xiangliang Yang
Reconciling the conflicting needs for prolonged circulation time, enhanced cellular uptake by bulk tumor cells and cancer stem cells (CSCs), and extensive tumor tissue penetration remains a major challenge for current nano drug delivery systems. Here we describe smart poly( N-isopropylacrylamide)-based nanogels with fast adaptive hydrophobicity to solve these contradictory requirements for enhanced cancer chemotherapy. The nanogels are hydrophilic in the blood to prolong their circulation time. Once they accumulate at tumor sites, they rapidly become hydrophobic in response to tumor extracellular acidity...
November 19, 2018: Nano Letters
Felix Lehmkühler, Joana Valerio, Dina Sheyfer, Wojciech Roseker, Martin A Schroer, Birgit Fischer, Kensuke Tono, Makina Yabashi, Tetsuya Ishikawa, Gerhard Grübel
The application of X-ray photon correlation spectroscopy (XPCS) at free-electron laser (FEL) facilities enables, for the first time, the study of dynamics on a (sub-)nanometre scale in an unreached time range between femtoseconds and seconds. For soft-matter materials, radiation damage is a major limitation when going beyond single-shot applications. Here, an XPCS study is presented at a hard X-ray FEL on radiation-sensitive polymeric poly( N -isopropylacrylamide) (PNIPAM) nanoparticles. The dynamics of aqueous suspensions of densely packed silica-PNIPAM core-shell particles and a PNIPAM nanogel below the radiation-damage threshold are determined...
November 1, 2018: IUCrJ
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