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Min Sun, Xin Wang, Xu Cheng, Le He, Guoqing Yan, Rupei Tang
Herein pH-sensitive nanogels (NG1) and P-glycoprotein-repressive nanogels (NG2) were prepared by copolymerization between an ortho ester crosslinker (OEAM) and tocopheryl polyethylene glycol succinate (TPGS)-free or conjugated dextran. Nanogels with or without TPGS possessed a uniform diameter (∼180 nm) and excellent stability in various physiological environments. Doxorubicin (DOX) was successfully loaded into NG1 and NG2 to give NG1/DOX and NG2/DOX, both of them showed appropriate drug release profiles under mildly acidic conditions (pH 5...
October 15, 2018: Carbohydrate Polymers
Sonal Deshpande, Smita Patil, Neetu Singh
Polo-like-kinase 1 (PLK1), which is a serine-threonine protein kinase overexpressed in cancer cells, is known to regulate tumor growth and have recently gathered attention as a target gene for RNA interference because of the poor bioavailability and nonspecificity of the available inhibitors. However, the lower transfection efficiency of siRNA and its poor stability in biological mileu necessitate the need of efficient siRNA delivery systems. Here, we report efficacious polymeric nanoparticles for the delivery of PLK1 siRNA in mammalian cancer cells...
July 31, 2018: ACS Omega
Guiqin Zheng, Shan Liu, Junqi Zha, Peng Zhang, Xuewei Xu, Yantao Chen, Shaoyi Jiang
Horseradish peroxidase (HRP) holds great potential in wastewater treatment. However, its instability in harsh environments remains a major issue. Various immobilization technologies were developed to retain enzyme stability at the cost of its effectiveness. We demonstrate that zwitterionic encapsulation of HRP retained both protein stability and activity to a large degree. In a water treatment study, encapsulating HRP into a zwitterionic nanogel resulted in a three-fold increase in the catalytic oxidation efficiency of phenol molecules...
August 6, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Leila Pourtalebi Jahromi, Soliman Mohammadi-Samani, Reza Heidari, Amir Azadi
PURPOSE: Although it passes through blood-brain barrier (BBB) very poorly, methotrexate (MTX) is an important therapeutic in the treatment of many central nervous system malignancies. Accordingly, intranasal (IN) administration accompanied with a muco-adhesive chitosan-based nanoformulation is expected to overcome this problem. METHODS: Nanogel containing MTX was prepared through an ionic gelation method and then characterized in terms of particle size, morphology, zeta potential, drug loading and drug release behavior...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Hindupur Ravi, Nawneet Kurrey, Yuki Manabe, Tatsuya Sugawara, Vallikannan Baskaran
Fucoxanthin (FUCO), a marine carotenoid is photo-, and thermo-labile and poorly bioavailable due to its lipophilicity. Hence, we developed a chitosan (CS) + glycolipid (GL) nanogels (NGs) to increase cellular uptake and anticancer efficacy of FUCO (10 μM) in human colon cells (Caco-2). Effect of FUCO loaded in NGs with/with no GL was studied in comparison with micellar FUCO. Results showed that the cell viability was lower (p < 0.05) in NGs + GL (50.5%) compared to NGs (-GL) (66.5%) and the mixed micelles (72...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Li-Ju Wang, Yu-Chung Chang, Allison T Osmanson, Jinwen Zhang, Lei Li
A facile continuous production of soy peptide nanogels was demonstrated using a multi-inlet vortex micromixer for the entrapment of active ingredients. The full flow regime in the micromixer was systematically studied to understand the flow impact on nanogel size, drug encapsulation efficiency and drug loading efficiency. Ibuprofen was chosen as a model drug to demonstrate encapsulation capability. The study showed that the nanogel size, drug encapsulation efficiency and drug loading efficiency did not alter significantly as long as the flow rates were in transition and turbulent regimes...
July 20, 2018: International Journal of Pharmaceutics
Yang Yao, Wen Liao, Ruichao Yu, Yu Du, Ting Zhang, Qiang Peng
Cardiac diseases have become the leading cause of death worldwide. Developing efficient strategies to treat such diseases is of great urgency. Stem cell-based regeneration medicine offers a novel approach for heart repair. However, low retention and poor survival rate of engrafted cells limit its applications. Nanomaterials have shown great potentials in addressing above issues due to nanoparticles-bio interactions. Therefore, combining nanomaterials and stem cell therapy is of great interest and significance for heart repair...
July 2018: Nanomedicine
Emily Mihalko, Ke Huang, Erin Sproul, Ke Cheng, Ashley C Brown
Myocardial infarction (MI), commonly known as a heart attack, affects millions of people worldwide and results in significant death and disabilities. A major cause of MI is fibrin-rich thrombus formation that occludes the coronary arteries, blocking blood flow to the heart and causing fibrin deposition. In treating MI, re-establishing blood flow is critical. However, ischemia reperfusion (I/R) injury itself can also occur and contributes to cardiac fibrosis. Fibrin-specific poly( N-isopropylacrylamide) nanogels (FSNs) comprised of a core-shell colloidal hydrogel architecture are utilized in this study to design a dual-delivery system that simultaneously addresses the need to (1) re-establish blood flow and (2) inhibit cardiac fibrosis following I/R injury...
July 25, 2018: ACS Nano
Kristyna Kolouchova, Ondrej Sedlacek, Daniel Jirak, David Babuka, Jan Blahut, Jan Kotek, Martin Vit, Jiri Trousil, Rafał Konefał, Olga Janouskova, Bohumila Podhorska, Miroslav Slouf, Martin Hruby
Magnetic resonance imaging using fluorinated contrast agents (19 F MRI) enables to achive highcontrast in images due to the negligible fluorine background in living tissues. In this pilot study, we developed new biocompatible, temperature-responsive, and easily synthesized polymeric nanogels containing a sufficient concentration of magnetically equivalent fluorine atoms for 19 F MRI purposes. The structure of the nanogels is based on amphiphilic copolymers containing two blocks, a hydrophilic poly[ N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(2-methyl-2-oxazoline) (PMeOx) block, and a thermoresponsive poly[ N(2,2difluoroethyl)acrylamide] (PDFEA) block...
July 27, 2018: Biomacromolecules
Debabrata Maiti, Yu Chao, Ziliang Dong, Xuan Yi, Jinlin He, Zhuang Liu, Kai Yang
Although chemo-radiotherapy has been widely applied in clinics for cancer treatment, current strategies still face many challenges including serious side-effects and drug resistance. Herein, we develop a chemically cross-linked poly-N,N'-dimethyl aminoethyl methacrylate (PDMAEMA) smart nanogel as an excellent thermosensitive nanocarrier to load both an anticancer drug, doxorubicin (DOX) and a radioisotope, 131 I-labeled albumin, for enhanced chemo-radioisotope therapy. Such a PDMAEMA nanogel in the solution form at room temperature can be easily injected into a tumor, in which it would be transformed into a gel at body temperature...
August 7, 2018: Nanoscale
Ting Wu, Weiping Liao, Wei Wang, Jie Zhou, Weiguo Tan, Weibing Xiang, Jinglin Zhang, Lina Guo, Tao Chen, Dong Ma, Weiye Yu, Xiang Cai
Lung-targeted genipin-crosslinked deacetylated chitosan (GEN-CS)/isoniazid (INH)/rifampin (RMP) nanogel particles (NGPs) were prepared as a treatment for tuberculosis caused by multidrug-resistant Mycobacterium tuberculosis (MTB) to surmount the undesirable side effects and decrease the cytotoxicity of INH and RMP when being against MTB. The size, morphology, in vitro release property, long-term antibacterial performance, stability, in vitro cytotoxicity, in vivo toxicity, and in vivo release property of GEN-CS/INH/RMP NGPs inhalation powder were investigated...
October 1, 2018: Carbohydrate Polymers
Hongyan Cao, Fenghao Guo, Zhiyong Chen, Xiang Zheng Kong
Stimuli-responsive polymers have received growing attention in recent years owing to their wide applications in diverse fields. A novel stimuli-responsive polymer, based on oligo(ethylene glycol) diacrylate (OEGDA) and methacrylic acid (MAA), P(OEGDA-MAA), is prepared by precipitation polymerization and is shown to have a LCST-type VPTT (volume phase transition temperature) at 33 °C in water and a UCST-type VPTT at 43 °C in ethanol, all at concentration of 1 mg/mL. Both VPTTs are strongly concentration and pH dependent, providing an easy way to tune the phase transition temperature...
July 13, 2018: Nanoscale Research Letters
Weiqi Zhang, Ching-Hsuan Tung
Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.
July 24, 2018: Chemical Communications: Chem Comm
Yihui Zhai, Wei Ran, Jinghan Su, Tianqun Lang, Jia Meng, Guanru Wang, Pengcheng Zhang, Yaping Li
Cytotoxic T lymphocyte (CTL) eliminates abnormal cells through target recognition-triggered intracellular toxin delivery. Chimeric antigen receptor T-cell improves cancer cell recognition of CTL, but its effectiveness and safety in solid tumor treatment are still hampered by poor tumor infiltration, suppressive tumor microenvironment, and severe on-target off-tumor toxicity. Given the functionality and challenges of CTL in cancer therapy, herein, a CTL-inspired nanovesicle (MPV) with a cell membrane-derived shell and a methylene blue (MB) and cisplatin (Pt) loaded gelatin nanogel core is created...
July 10, 2018: Advanced Materials
Li Tang, Yiran Zheng, Mariane Bandeira Melo, Llian Mabardi, Ana P Castaño, Yu-Qing Xie, Na Li, Sagar B Kudchodkar, Hing C Wong, Emily K Jeng, Marcela V Maus, Darrell J Irvine
Adoptive cell therapy (ACT) with antigen-specific T cells has shown remarkable clinical success; however, approaches to safely and effectively augment T cell function, especially in solid tumors, remain of great interest. Here we describe a strategy to 'backpack' large quantities of supporting protein drugs on T cells by using protein nanogels (NGs) that selectively release these cargos in response to T cell receptor activation. We designed cell surface-conjugated NGs that responded to an increase in T cell surface reduction potential after antigen recognition and limited drug release to sites of antigen encounter, such as the tumor microenvironment...
July 9, 2018: Nature Biotechnology
Maedeh Barati, Soliman Mohammadi Samani, Leila Pourtalebi Jahromi, Hajar Ashrafi, Amir Azadi
Chronic pain is one of the most prevalent health problems worldwide. Tramadol is a synthetic semi-opioid analgesic, interacting with serotonergic, adrenergic and opioid receptors to reduce the pain but its short half-life in vivo may reduce patient compliance in case of chronic pains. To overcome this problem, novel drug delivery systems have been investigated. This study focuses on a chitosan based thermoresponsive in-situ gel forming formulation intended to subcutaneous injection. To evaluate further drug release, a reversed phase high performance liquid chromatography method was developed...
July 5, 2018: International Journal of Biological Macromolecules
Xiurong Gao, Hui Yang, Min Wu, Kun Shi, Cheng Zhou, Jinrong Peng, Qian Yang
Tumor growth inhibition and adverse effect reduction together with metastasis alleviation are still the challenges that need to be overcome in cancer chemotherapy. Combinational therapy provides an alternative solution for these challenges. Nanoparticles are the ideal carriers for combinational therapy due to their versatile drug loading capacities and versatile tumor-targeting strategies. In this study, a cRGDfk modified nanogel system has been utilized to coload lidocaine, a voltage-gated Na+ channels inhibitor, and cisplatin, a common anticancer drug to obtain a tumor-targeted dual drugs-loaded nanogel system...
August 1, 2018: ACS Applied Materials & Interfaces
Dechun Huang, Hongliang Qian, Haishi Qiao, Wei Chen, Jan Feijen, Zhiyuan Zhong
INTRODUCTION: Bioresponsive nanogels with a crosslinked three-dimensional structure and an aqueous environment that undergo physical or chemical changes including swelling and dissociation in response to biological signals such as mild acidity, hyperthermia, enzymes, reducing agents, reactive oxygen species (ROS), and adenosine-5'-triphosphate (ATP) present in tumor microenvironments or inside cancer cells have emerged as an appealing platform for targeted drug delivery and cancer therapy...
July 2018: Expert Opinion on Drug Delivery
Haika Hildebrandt, Outi Paloheimo, Elina Mäntylä, Sami Willman, Satu Hakanen, Krystyna Albrecht, Jürgen Groll, Martin Möller, Maija Vihinen-Ranta
This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spherical particles with an adjustable size of 100-200 nm by self-assembly and subsequent covalent cross-linking without the need for organic solvents or surfactants. Covalent attachment of a fluorescence dye and either the cell-penetrating TAT peptide or a random control peptide sequence shows that only TAT-labeled nanogels are internalized by HeLa cells...
July 4, 2018: Macromolecular Bioscience
Manuel Toledano, Inmaculada Cabello, Estrella Osorio, Fátima S Aguilera, Antonio Luis Medina-Castillo, Manuel Toledano-Osorio, Raquel Osorio
OBJECTIVE: Nanogels designing for effective treatment of eroded cervical dentin lesions. MATERIALS AND METHODS: Polymethylmetacrylate-based nanoparticles (NPs) were doxycycline (D), calcium, or zinc loaded. They were applied on eroded cervical dentin. Treated surfaces were characterized morphologically by atomic force and scanning electron microscopy, mechanically probed by a nanoindenter to test nanohardness and Young's modulus, and chemically analyzed by Raman spectroscopy at 24 h and 7 days of storage...
July 3, 2018: Clinical Oral Investigations
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