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https://www.readbyqxmd.com/read/29161401/the-evolution-of-airway-management-new-concepts-and-conflicts-with-traditional-practice
#1
A F McNarry, A Patel
In the last 25 yr, there have been several advances in the safe management of the airway. Videolaryngoscopes and supraglottic airways, now in routine use by new trainees in anaesthesia, have had their genesis in the recent past. The 4th National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society published in 2011 a seminal report that has influenced airway management worldwide . Understanding how the report's recommendations were constructed and how clinical guidelines compliment rather than contradict them is important in understanding the tenets of safe airway management...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29159034/hamman-rich-syndrome
#2
Arshiya Mastan, Nilaani Murugesu, Adil Hasnain, Terry O'Shaughnessy, Vladimir Macavei
INTRODUCTION: Acute interstitial pneumonia is a rare but important diagnosis, associated with a high mortality rate and important to identify early. CASE PRESENTATION: A 76 year-old individual presented to hospital with a two-week history of shortness of breath, fevers and a non-productive cough. Treatment initially was for lower respiratory tract infection but returned to hospital three days later as her shortness of breath and peripheral oedema was worsening despite diuretic treatment...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29158058/regional-cerebral-oxygen-saturation-level-predicts-30-day-mortality-rate-after-left-ventricular-assist-device-surgery
#3
Soutik Ghosal, Jaimin Trivedi, James Chen, Michael P Rogers, Allen Cheng, Mark S Slaughter, Maiying Kong, Jiapeng Huang
OBJECTIVE: Left ventricular assist device (LVAD) surgery is complex, high risk, and expensive. The authors' hypothesis is baseline regional cerebral oxygen saturation (rSO2) might be a predictor of postoperative clinical outcomes. DESIGN: Retrospective review of 210 consecutive continuous flow LVAD patients between 2008 and 2014. The primary measure is 30-day mortality rate and secondary measures include modified major adverse cardiocerebral events (MACE), length of stay (LOS), and intensive care unit (ICU) stay...
August 19, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29154978/7-ketocholesterol-induces-ros-mediated-mrna-expression-of-12-lipoxygenase-cyclooxygenase-2-and-pro-inflammatory-cytokines-in-human-mesangial-cells-potential-role-in-diabetic-nephropathy
#4
Yasuhiro Watanabe, Takashi Yamaguchi, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Rena Oka, Haruki Imamura, Yuta Sato, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Naomi Shimizu, Atsuhito Saiki, Ichiro Tatsuno
7-Ketocholesterol (7-KCHO) is a highly proinflammatory oxysterol and plays an important role in the pathophysiology of diabetic nephropathy (DN). Lipoxygenases (LOXs) and cyclooxygenases (COXs) are also involved in the development of DN. The aim of this study was to clarify the effects of 7-KCHO on mRNA expression of LOXs and COXs as well as pro-inflammatory cytokines in human mesangial cells (HMC). We evaluated cell viability by WST-8 assay and measured mRNA expression by reverse transcription-polymerase chain reaction...
November 15, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29152653/elaidic-acid-induces-cell-apoptosis-through-induction-of-ros-accumulation-and-endoplasmic-reticulum-stress-in-sh%C3%A2-sy5y-cells
#5
Wei-Wei Ma, Lei Zhao, Lin-Hong Yuan, Huan-Ling Yu, Hui Wang, Xin-Yuan Gong, Feng Wei, Rong Xiao
Elaidic acid, which is a major trans fatty acid, has been reported to be involved in neurotoxicity; however, the underlying molecular mechanisms underlying its neurotoxic effects remain largely unknown. Therefore, the present study aimed to investigate the potential mechanisms underlying elaidic acid‑induced neuronal damage in vitro. The SH‑SY5Y neuroblastoma cell line was used as a model in the present study. Following treatment of cells with various concentrations of elaidic acid or with vehicle for 24 h, cell viability was measured using the MTT assay...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29149868/can-high-flow-nasal-cannula-reduce-the-rate-of-reintubation-in-adult-patients-after-extubation-a-meta-analysis
#6
Yue-Nan Ni, Jian Luo, He Yu, Dan Liu, Bin-Miao Liang, Rong Yao, Zong-An Liang
BACKGROUND: The effects of high flow nasal cannula (HFNC) on adult patients after extubation remain controversial. We aimed to further determine the effectiveness of HFNC in comparison to noninvasive positive pressure ventilation (NIPPV) and conventional oxygen therapy (COT). METHODS: The Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trails (CENTRAL) as well as the Information Sciences Institute (ISI) Web of Science were searched for all the controlled study comparing HFNC with NIPPV and COT in adult patients after extubation...
November 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29149867/efficacy-and-safety-of-nasal-high-flow-oxygen-in-copd-patients
#7
Helene Vogelsinger, Michael Halank, Silke Braun, Heinrike Wilkens, Thomas Geiser, Sebastian Ott, Armin Stucki, Christian M Kaehler
BACKGROUND: Nasal high-flow oxygen therapy (HFOT) is a novel treatment option for patients suffering from acute or chronic respiratory failure. Aim of our study was to compare safety and efficacy of HFOT with those of conventional oxygen treatment (COT) in normo- and hypercapnic COPD patients. METHODS: A single cohort of 77 clinically stable hypoxemic patients with an indication for long-term oxygen treatment (LTOT) with or without hypercapnia successively received COT and HFOT for 60 min each, including oxygen adaption and separated by a 30 min washout phase...
November 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29149690/a-modified-montpellier-protocol-for-intubating-intensive-care-unit-patients-is-associated-with-an-increase-in-first-pass-intubation-success-and-fewer-complications
#8
Keith A Corl, Christopher Dado, Ankita Agarwal, Nader Azab, Tim Amass, Sarah J Marks, Mitchell M Levy, Roland C Merchant, Jason Aliotta
BACKGROUND: The Montpellier protocol for intubating patients in the intensive care unit (ICU) is associated with a decrease in intubation-related complications. We sought to determine if implementation of a simplified version of the Montpellier protocol that removed selected components and allowed for a variety of pre-oxygenation modalities increased first-pass intubation success and reduced intubation-related complications. METHODS: A prospective pre/post-comparison of a modified Montpellier protocol in two medical and one medical/surgical/cardiac ICU within a hospital system...
November 10, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29148988/humidified-high-flow-nasal-cannula-oxygen-more-than-just-supplemental-oxygen
#9
Neil R MacIntyre
No abstract text is available yet for this article.
December 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29145851/ala-la-ameliorates-glucose-toxicity-on-hk-2-cells-by-attenuating-oxidative-stress-and-apoptosis-through-the-ros-p38-tgf-%C3%AE-1-pathway
#10
Mingxia Jiang, Haifen Zhang, Lijie Zhai, Bianliang Ye, Yin Cheng, Chengkai Zhai
BACKGROUND: Growing evidence indicates that oxidative stress (OS) plays a pivotal role in Diabetic nephropathy (DN). In a previous study we demonstrated that ALA/LA protected HK-2 cells against high glucose-induced cytotoxicity. So we aimed to establish the glucose injury model of HK-2 cells and investigate the beneficial effects of ALA/LA on high glucose-induced excessive production of TGF-β1 and the possible mechanisms mediating the effects. METHODS: The expression of OS markers in high glucose-induced HK-2 cells treated with ALA/LA...
November 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29144720/cost-effectiveness-of-gammacore-non-invasive-vagus-nerve-stimulation-for-acute-treatment-of-episodic-cluster-headache
#11
Mkaya Mwamburi, Eric J Liebler, Andrew T Tenaglia
Cluster headache is a debilitating disease characterized by excruciatingly painful attacks that affects 0.15% to 0.4% of the US population. Episodic cluster headache manifests as circadian and circannual seasonal bouts of attacks, each lasting 15 to 180 minutes, with periods of remission. In chronic cluster headache, the attacks occur throughout the year with no periods of remission. While existing treatments are effective for some patients, many patients continue to suffer. There are only 2 FDA-approved medications for episodic cluster headache in the United States, while others, such as high-flow oxygen, are used off-label...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29144292/the-response-of-nitrous-oxide-emissions-to-different-operating-conditions-in-activated-sludge-wastewater-treatment-plants-in-southeastern-brazil
#12
Renato P Ribeiro, Rodrigo F Bueno, Roque P Piveli, Débora C Kligerman, William Z de Mello, Jaime L M Oliveira
The continuous measurements of N2O emissions from the aeration tanks of three activated sludge wastewater treatment plants (WWTPs) operated with biological nitrogen removal (BNR) and non-BNR were performed during the different operating conditions of several parameters, such as aeration, dissolved oxygen (DO) profiling and organic shock loading (with landfill leachate). The nitrification process is the main driving force behind N2O emission peaks. There are indications that the variation of the air flow rate influenced N2O emissions; high N2O emissions denote over-aeration conditions or incomplete nitrification, with accumulation of NO2(-) concentrations...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29144160/high-flow-nasal-cannula-oxygen-in-adults-an-evidence-based-assessment
#13
Matthew G Drake
High flow nasal cannula oxygenation has distinct advantages over other oxygen devices due to its unique effects on respiratory physiology. In particular, adjustable oxygen delivery and flow-dependent carbon dioxide clearance from the upper airway reduce work of breathing and can better match inspiratory demand during respiratory distress. Historically, few studies had evaluated whether the physiologic effects of these devices translated into clinical benefit. However, recent publications have begun to address this knowledge gap...
November 16, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29141882/transparent-anemone-shrimp-ancylomenes-pedersoni-become-opaque-after-exercise-and-physiological-stress-in-correlation-with-increased-hemolymph-perfusion
#14
Laura E Bagge, Stephen T Kinsey, Justin Gladman, Sönke Johnsen
Whole-body transparency, an effective camouflage strategy in many aquatic species, can be disrupted by environmental and/or physiological stressors. We found that tail-flip escape responses temporarily disrupt the transparency of the anemone shrimp Ancylomenes pedersoni After as few as three tail flips, the previously transparent abdominal muscle became cloudy. Eliciting additional tail flips to the point of exhaustion (16±1 s.e.m.; n=23) resulted in complete opacity, though the original transparency returned after 20-60 min of inactivity...
November 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29136945/mitochondria-protection-as-a-mechanism-underlying-the-hepatoprotective-effects-of-glycine-in-cholestatic-mice
#15
Reza Heidari, Vahid Ghanbarinejad, Hamidreza Mohammadi, Asrin Ahmadi, Mohammad Mehdi Ommati, Narges Abdoli, Fatemeh Aghaei, Athena Esfandiari, Negar Azarpira, Hossein Niknahad
Cholestasis is the stoppage of bile flow which could lead to serious clinical complications if not managed. Cytotoxic bile acids are involved in the pathogenesis of liver injury during cholestasis. There are no promising pharmacological interventions against cholestasis and its associated complications. This study examined the impact of glycine supplementation on liver mitochondria as a major target of bile acids-induced toxicity during cholestasis. Mice underwent BDL operation and received glycine (0.25% and 1% w:v in drinking water)...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136941/enhanced-granulation-and-methane-recovery-at-low-load-by-downflow-sludge-circulation-in-anaerobic-treatment-of-domestic-wastewater
#16
Yangyang Liu, Lihui Huang, Guihua Dong, Gaofeng Liu, Xueyuan Wu, Chuang Wang, Xiaowei Liu, Lisha Wang
The effects of downflow sludge circulation on granulation and methane recovery at low load were investigated for domestic wastewater treatment in a modified anaerobic reactor. Compared with conventional upflow anaerobic reactors, enhanced granulation with shortened start-up time was achieved and stable granules were successfully cultivated only after 58 days operations. The introduction of downflow sludge circulation resulted in reverse wastewater-sludge flow and uniform sludge distribution in the reaction zone, which contributed to enhanced wastewater-sludge mass transfer and satisfactory performance with a high soluble chemical oxygen demand (SCOD) removal efficiency of 94...
October 31, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29135861/in-vitro-and-in-vivo-antimelanoma-effect-of-ethyl-ester-cyclohexyl-analog-of-ethylenediamine-dipropanoic-acid
#17
Andjelka M Isakovic, Sasa M Petricevic, Slavica M Ristic, Dusan M Popadic, Tamara K Kravic-Stevovic, Nevena S Zogovic, Jelena M Poljarevic, Tatjana V Zivanovic Radnic, Tibor J Sabo, Aleksandra J Isakovic, Ivanka D Markovic, Vladimir S Trajkovic, Sonja T Misirlic-Dencic
Melanoma, an aggressive skin tumor with high metastatic potential, is associated with high mortality and increasing morbidity. Multiple available chemotherapeutic and immunotherapeutic modalities failed to improve survival in advanced disease, and the search for new agents is ongoing. The aim of this study was to investigate antimelanoma effects of O,O-diethyl-(S,S)-ethylenediamine-N,N'di-2-(3-cyclohexyl) propanoate dihydrochloride (EE), a previously synthesized and characterized organic compound. Mouse melanoma B16 cell viability was assessed using acid phosphatase, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, sulforhodamine B, and lactate dehydrogenase assays...
November 13, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29134262/evaluating-use-of-environmental-flows-to-aerate-streams-by-modelling-the-counterfactual-case
#18
Michael J Stewardson, Dominic Skinner
This paper evaluates an experimental environmental flow manipulation by modeling the counterfactual case that no environmental flow was applied. This is an alternate approach to evaluating the effect of an environmental flow intervention when a before-after or control-impact comparison is not possible. In this case, the flow manipulation is a minimum flow designed to prevent hypoxia in a weir on the low-gradient Broken Creek in south-eastern Australia. At low flows, low reaeration rates and high respiration rates associated with elevated organic matter loading in the weir pool can lead to a decline in dissolved oxygen concentrations with adverse consequences both for water chemistry and aquatic biota...
November 13, 2017: Environmental Management
https://www.readbyqxmd.com/read/29131002/low-tidal-volume-positive-end-expiratory-pressure-versus-high-tidal-volume-zero-positive-end-expiratory-pressure-and-postoperative-pulmonary-functions-in-robot-assisted-laparoscopic-radical-prostatectomy
#19
Murat Haliloglu, Beliz Bilgili, Mehtap Ozdemir, Tumay Umuroglu, Nurten Bakan
OBJECTIVE: The aim was to compare the effects of low tidal volume (VT) and moderate positive end-expiratory pressure(PEEP) with high tidal volume (VT) and zero end-expiratory pressure(ZEEP), on postoperative pulmonary functions and oxygenation in patients undergoing robot-assisted laparoscopic radical prostatectomy. SUBJECTS AND METHODS: Forty-four (44) patients were randomized into low VT-PEEP and high VT-ZEEP groups. The patients were ventilated with VT of 6 ml/kg and 8 cmH2O PEEP in low VT-PEEP group and VT of 10 ml/kg and 0 cmH2O PEEP in high VT-ZEEP group...
October 31, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29129174/high-flow-or-titrated-oxygen-for-obese-medical-inpatients-a-randomised-crossover-trial
#20
Janine Pilcher, Michael Richards, Leonie Eastlake, Steven J McKinstry, George Bardsley, Sarah Jefferies, Irene Braithwaite, Mark Weatherall, Richard Beasley
OBJECTIVE: To compare the effects on transcutaneous carbon dioxide tension (Ptco2) of high concentration and titrated oxygen therapy in medical inpatients with morbid obesity who were not selected for a pre-existing diagnosis of obesity hypoventilation syndrome. DESIGN: A randomised, crossover trial undertaken between February and September 2015. SETTING: Internal medicine service, Wellington Regional Hospital, New Zealand. PARTICIPANTS: 22 adult inpatients, aged 16 years or more, with a body mass index exceeding 40 kg/m<sup>2</sup>...
November 20, 2017: Medical Journal of Australia
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