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https://www.readbyqxmd.com/read/28932993/oxygen-therapy-with-high-flow-nasal-cannula-as-an-effective-treatment-for-perioperative-pneumocephalus-case-illustrations-and-pathophysiological-review
#1
Jason L Siegel, Karen Hampton, Alejandro A Rabinstein, Diane McLaughlin, Jose L Diaz-Gomez
Pneumocephalus (PNC) is a condition in which when air is trapped inside the intracranial vault. The causes are varied, but include trauma and intracranial surgery. Treatment of PNC typically consists of augmenting patient oxygenation with the attempt of washing out pulmonary nitrogen, creating a gradient in which nitrogen in the intracranial air bubble diffuses out of the lungs via the blood. Though several high flow methods have been tested, the ideal mode of oxygenation has not fully been investigated. Here we present 3 cases of post-operative PNC who we felt were symptomatic from PNC...
September 20, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28932500/effects-of-low-load-resistance-exercise-with-blood-flow-restriction-on-high-energy-phosphate-metabolism-and-oxygenation-level-in-skeletal-muscle
#2
Osamu Yanagisawa, Manabu Sanomura
We aimed to evaluate the effects of low-load resistance exercise with blood flow restriction (BFR) on high-energy phosphate metabolism, intracellular pH, and oxygenation level in the skeletal muscle. Seven males performed low-load ankle plantar flexion exercise (120 repetitions, 30% of one-repetition maximum) with and without BFR (130% of systolic blood pressure) inside a magnetic resonance device. Inorganic phosphate (Pi)-to-phosphocreatine (PCr) ratio, intracellular pH, and tissue oxygenation index (TOI) in the medial gastrocnemius were determined using (31)P-magnetic resonance spectroscopy and near-infrared spectroscopy before and during exercise...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28931042/evaluation-of-the-cytotoxicity-of-the-bithionol-paclitaxel-combination-in-a-panel-of-human-ovarian-cancer-cell-lines
#3
Vijayalakshmi N Ayyagari, Paula L Diaz-Sylvester, Tsung-Han Jeff Hsieh, Laurent Brard
Previously, Bithionol (BT) was shown to enhance the chemosensitivity of ovarian cancer cell lines to cisplatin treatment. In the present study, we focused on the anti-tumor potential of the BT-paclitaxel combination when added to a panel of ovarian cancer cell lines. This in vitro study aimed to 1) determine the optimum schedule for combination of BT and paclitaxel and 2) assess the nature and mechanism(s) underlying BT-paclitaxel interactions. The cytotoxic effects of both drugs either alone or in combination were assessed by presto-blue cell viability assay using six human ovarian cancer cell lines...
2017: PloS One
https://www.readbyqxmd.com/read/28929206/adaptive-management-of-environmental-flows-using-irrigation-infrastructure-to-deliver-environmental-benefits-during-a-large-hypoxic-blackwater-event-in-the-southern-murray-darling-basin-australia
#4
Robyn J Watts, R Keller Kopf, Nicole McCasker, Julia A Howitt, John Conallin, Ian Wooden, Lee Baumgartner
Widespread flooding in south-eastern Australia in 2010 resulted in a hypoxic (low dissolved oxygen, DO) blackwater (high dissolved carbon) event affecting 1800 kilometres of the Murray-Darling Basin. There was concern that prolonged low DO would result in death of aquatic biota. Australian federal and state governments and local stakeholders collaborated to create refuge areas by releasing water with higher DO from irrigation canals via regulating structures (known as 'irrigation canal escapes') into rivers in the Edward-Wakool system...
September 19, 2017: Environmental Management
https://www.readbyqxmd.com/read/28928616/chronic-antepartum-maternal-hyperoxygenation-in-a-case-of-severe-fetal-ebstein-s-anomaly-with-circular-shunt-physiology
#5
Alisa Arunamata, David M Axelrod, Katherine Bianco, Sowmya Balasubramanian, Amy Quirin, Theresa A Tacy
Perinatal mortality remains high among fetuses diagnosed with Ebstein's anomaly of the tricuspid valve. The subgroup of patients with pulmonary valve regurgitation is at particularly high risk. In the setting of pulmonary valve regurgitation, early constriction of the ductus arteriosus may be a novel perinatal management strategy to reduce systemic steal resulting from circular shunt physiology. We report the use of chronic antepartum maternal oxygen therapy for constriction of the fetal ductus arteriosus and modulation of fetal pulmonary vascular resistance in a late presentation of Ebstein's anomaly with severe tricuspid valve regurgitation, reversal of flow in the ductus arteriosus, and continuous pulmonary valve regurgitation...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28926744/chronic-high-protein-diet-induces-oxidative-stress-and-alters-the-salivary-gland-function-in-rats
#6
Urszula Kołodziej, Mateusz Maciejczyk, Wiesława Niklińska, Danuta Waszkiel, Małgorzata Żendzian-Piotrowska, Piotr Żukowski, Anna Zalewska
OBJECTIVE: Chronic high protein intake leads to an increase in reactive oxygen species (ROS) generation. However, there is no data on the impact of high-protein diet on the antioxidant barrier, oxidative stress and secretory function in the salivary glands of healthy individuals. DESIGN: 16 male Wistar rats were randomly divided into 2 groups (n=8): normal protein (C) and high-protein diet (HP) for 8 weeks. Salivary antioxidants: peroxidase (Px), catalase (CAT), superoxide dismutase 1 (SOD 1), uric acid (UA), total antioxidant status (TAS), total oxidant status (TOS) and the oxidative stress index (OSI), as well as protein carbonyls (PC), 4-hydroxynonenal protein adduct (4-HNE protein adduct), 8-isoprostanes (8-isoP), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and protein content were determined in the salivary glands and plasma...
September 10, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28923379/synthesis-characterization-cellular-uptake-and-apoptosis-inducing-properties-of-two-highly-cytotoxic-cyclometalated-ruthenium-ii-%C3%AE-carboline-complexes
#7
Jincan Chen, Fa Peng, Yao Zhang, Baojun Li, Ji She, Xinming Jie, Zhilin Zou, Man Chen, Lanmei Chen
Two new cyclometalated Ru(II) complexes of the general formula [Ru(N-N)2(1-Ph-βC)](PF6), where N-N = 4,4'-dimethyl-2,2'-bipyridine (dmb, Ru1), 2,2'-bipyridine (bpy, Ru2), and 1-Ph-βC (1-phenyl-9H-pyrido[3,4-b]indole) is a β-carboline alkaloids derivatives, have been synthesized and characterized. The in vitro cytotoxicities, cellular uptake and localization, cell cycle arrest and apoptosis-inducing mechanisms of these complexes have been extensively explored by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, inductively coupled plasma mass spectrometry (ICP-MS), flow cytometry, comet assay, inverted fluorescence microscope as well as western blotting experimental techniques...
September 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28921478/interstitial-pneumonia-with-autoimmune-features-an-additional-risk-factor-for-ards
#8
Giacomo Grasselli, Beatrice Vergnano, Maria Rosa Pozzi, Vittoria Sala, Gabriele D'Andrea, Vittorio Scaravilli, Marco Mantero, Alberto Pesci, Antonio Pesenti
BACKGROUND: Interstitial pneumonia with autoimmune features (IPAF) identifies a recently recognized autoimmune syndrome characterized by interstitial lung disease and autoantibodies positivity, but absence of a specific connective tissue disease diagnosis or alternative etiology. We retrospectively reviewed the clinical presentation, diagnostic workup and management of seven critically ill patients who met diagnostic criteria for IPAF. We compared baseline characteristics and clinical outcome of IPAF patients with those of the population of ARDS patients admitted in the same period...
September 18, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28918088/evaluation-of-cerebrovascular-reactivity-in-subjects-with-and-without-obstructive-sleep-apnea
#9
Clodagh M Ryan, Anne Battisti-Charbonney, Olivia Sobczyk, David J Mikulis, James Duffin, Joseph A Fisher, Lashmi Venkatraghavan
BACKGROUND: Both obstructive sleep apnea (OSA) and altered cerebrovascular reactivity (CVR) are associated with increased stroke risk. Nevertheless, the incidence of abnormal CVR in patients with OSA is uncertain due to the high variability in the way CVR is measured both within and between studies. We hypothesized that a standardized CVR with a consistent vasoactive stimulus and cerebral blood flow (CBF) measure would be reduced in patients with severe OSA compared with healthy controls...
September 13, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28915479/effect-of-design-and-operational-conditions-on-the-performance-of-subsurface-flow-treatment-wetlands-emerging-organic-contaminants-as-indicators
#10
Stefanie Kahl, Jaime Nivala, Manfred van Afferden, Roland A Müller, Thorsten Reemtsma
Six pilot-scale subsurface flow treatment wetlands loaded with primary treated municipal wastewater were monitored over one year for classical wastewater parameters and a set of emerging organic compounds (EOCs) serving as process indicators for biodegradation: caffeine, ibuprofen, naproxen, benzotriazole, diclofenac, acesulfame, and carbamazepine. The wetland technologies investigated included conventional horizontal flow, unsaturated vertical flow (single and two-stage), horizontal flow with aeration, vertical flow with aeration, and reciprocating...
September 5, 2017: Water Research
https://www.readbyqxmd.com/read/28914339/do-we-need-randomized-clinical-trials-in-extracorporeal-respiratory-support-yes
#11
EDITORIAL
Alain Combes, Antonio Pesenti, Daniel Brodie
Extracorporeal respiratory support, also known as extracorporeal gas exchange, may be used to rescue the most severe forms of acute hypoxemic respiratory failure with high blood flow venovenous extracorporeal membrane oxygenation. Alternatively, lower flow extracorporeal carbon dioxide removal might be applied to reduce the intensity of mechanical ventilation in patients with less severe forms of the disease. However, critical reading of the results of the randomized trials and case series published to date reveals major methodological biases...
September 15, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28912276/cavin-2-regulates-the-activity-and-stability-of-endothelial-nitric-oxide-synthase-enos-in-angiogenesis
#12
Gandhi T K Boopathy, Madhura Kulkarni, Sze Yuan Ho, Adrian Boey, Edmond Wei Min Chua, Veluchamy A Barathi, Tom J Carney, Xiaomeng Wang, Wanjin Hong
Angiogenesis is a highly regulated process for formation of new blood vessels from pre-existing ones. Angiogenesis is dysregulated in various pathologies, including age-related macular degeneration, arthritis, and cancer. Inhibiting pathological angiogenesis therefore represents a promising therapeutic strategy for treating these disorders, highlighting the need to study angiogenesis in more detail. To this end, identifying the genes essential for blood vessel formation and elucidating their function are crucial for a complete understanding of angiogenesis...
September 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28912130/near-infrared-spectroscopy-of-superficial-and-deep-rectus-femoris-reveals-markedly-different-exercise-response-to-superficial-vastus-lateralis
#13
Shunsaku Koga, Dai Okushima, Thomas J Barstow, Harry B Rossiter, Narihiko Kondo, David C Poole
To date our knowledge of skeletal muscle deoxygenation as measured by near-infrared spectroscopy (NIRS) is predicated almost exclusively on sampling of superficial muscle(s), most commonly the vastus lateralis (VL-s). Recently developed high power NIRS facilitates simultaneous sampling of deep (i.e., rectus femoris, RF-d) and superficial muscles of RF (RF-s) and VL-s. Because deeper muscle is more oxidative with greater capillarity and sustains higher blood flows than superficial muscle, we used time-resolved NIRS to test the hypotheses that, following exercise onset, the RF-d has slower deoxy[Hb+Mb] kinetics with reduced amplitude than superficial muscles...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28911294/potential-for-inadvertent-airway-delivery-of-carbon-dioxide-with-humidified-high-flow-oxygen-circuit
#14
C M Ironfield, D A Scott
No abstract text is available yet for this article.
September 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28910531/propane-water-mixtures-confined-within-cylindrical-silica-nano-pores-structural-and-dynamical-properties-probed-by-molecular-dynamics
#15
Tran Thi Bao Le, Alberto Striolo, Siddharth Gautam, David R Cole
Despite the multiple length and time scales over which fluid-mineral interactions occur, interfacial phenomena control the exchange of matter and impact the nature of multiphase flow, as well as the reactivity of C-O-H fluids in geologic systems. In general, the properties of confined fluids, and their influence on porous geologic phenomena are much less well understood compared to those of bulk fluids. We used equilibrium molecular dynamics simulations to study fluid systems composed of propane and water, at different compositions, confined within cylindrical pores of diameter ~16 Å carved out of amorphous silica...
September 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28901662/acute-hypoxemia-and-vascular-function-in-healthy-humans
#16
N C S Lewis, A R Bain, K W Wildfong, D J Green, P N Ainslie
Endothelium-dependent flow mediated dilation (FMD) and endothelium-independent dilation (GTN) are impaired at high altitude (5050 m), and FMD is impaired following acute exposure (<60-minutes) to normobaric hypoxia equivalent to ∼5050 m (∼FI O2  = 0.11). Whether glyceryl trinitrate (GTN)-induced dilation is impaired acutely, and whether FMD is impaired during milder hypoxia is unknown. Therefore, we assessed brachial FMD at baseline and following 30-minutes of mild (74 ± 2 mmHg PET O₂) and moderate (50 ± 3 mmHg PET O₂) normobaric hypoxia (n = 12) or normoxia (time-control trial; n = 10)...
September 13, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28893018/changes-in-gas-composition-during-low-flow-anaesthesia-without-nitrous-oxide
#17
Ranjana Venkatachalapathy, Anusha Cherian, Sakthirajan Panneerselvam
INTRODUCTION: Low flow anaesthesia utilising Oxygen (O2) and Nitrous Oxide (N2O) mixture carries a risk of hypoxia, but avoiding N2O results in increased analgesic and volatile anaesthetic agent requirement. AIM: This study attempted to find the lowest Fraction of inspired Oxygen (FiO2) levels achieved with a mixture of 300 mL/min each of O2 and medical air over two hours and to compare the overall analgesic requirement and cost while using similar flows of N2O and O2, respectively...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892283/kinetics-of-nh3-oxidation-no-turnover-n2-o-production-and-electron-flow-during-oxygen-depletion-in-model-bacterial-and-archaeal-ammonia-oxidisers
#18
Linda Hink, Pawel Lycus, Cécile Gubry-Rangin, Åsa Frostegård, Graeme W Nicol, James I Prosser, Lars R Bakken
Ammonia oxidising bacteria (AOB) are thought to emit more nitrous oxide (N2 O) than ammonia oxidising archaea (AOA), due to their higher N2 O yield under oxic conditions and denitrification in response to oxygen (O2 ) limitation. We determined the kinetics of growth and turnover of nitric oxide (NO) and N2 O at low cell densities of Nitrosomonas europaea (AOB) and Nitrosopumilus maritimus (AOA) during gradual depletion of TAN (NH3  + NH4(+) ) and O2 . Half-saturation constants for O2 and TAN were similar to those determined by others, except for the half-saturation constant for ammonium in N...
September 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28885752/dual-echo-asl-contributes-to-decrypting-the-link-between-functional-connectivity-and-cerebral-blow-flow
#19
Silvia F Storti, Ilaria Boscolo Galazzo, Stefania Montemezzi, Gloria Menegaz, Francesca B Pizzini
Arterial spin labeling (ASL) MRI with a dual-echo readout module (DE-ASL) enables noninvasive simultaneous acquisition of cerebral blood flow (CBF)-weighted images and blood oxygenation level dependent (BOLD) contrast. Up to date, resting-state functional connectivity (FC) studies based on CBF fluctuations have been very limited, while the BOLD is still the method most frequently used. The purposes of this technical report were (i) to assess the potentiality of the DE-ASL sequence for the quantification of resting-state FC and brain organization, with respect to the conventional BOLD (cvBOLD) and (ii) to investigate the relationship between a series of complex network measures and the CBF information...
September 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28883928/cpap-impact-a-protocol-for-a-randomised-trial-of-bubble-continuous-positive-airway-pressure-versus-standard-care-for-high-risk-children-with-severe-pneumonia-using-adaptive-design-methods
#20
Andrew G Smith, Michelle Eckerle, Tisungane Mvalo, Brian Weir, Francis Martinson, Alfred Chalira, Norman Lufesi, Innocent Mofolo, Mina Hosseinipour, Eric D McCollum
INTRODUCTION: Pneumonia is a leading cause of mortality among children in low-resource settings. Mortality is greatest among children with high-risk conditions including HIV infection or exposure, severe malnutrition and/or severe hypoxaemia. WHO treatment recommendations include low-flow oxygen for children with severe pneumonia. Bubble continuous positive airway pressure (bCPAP) is a non-invasive support modality that provides positive end-expiratory pressure and oxygen. bCPAP is effective in the treatment of neonates in low-resource settings; its efficacy is unknown for high-risk children with severe pneumonia in low-resource settings...
2017: BMJ Open Respiratory Research
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