Read by QxMD icon Read

perfluorinated compounds

Rossella Ghisi, Teofilo Vamerali, Sergio Manzetti
PFASs are a class of compounds that include perfluoroalkyl and polyfluoroalkyl substances, some of the most persistent pollutants still allowed - or only partially restricted - in several product fabrications and industrial applications worldwide. PFASs have been shown to interact with blood proteins and are suspected of causing a number of pathological responses, including cancer. Given this threat to living organisms, we carried out a broad review of possible sources of PFASs and their potential accumulation in agricultural plants, from where they can transfer to humans through the food chain...
October 30, 2018: Environmental Research
Jiaoqin Liu, Chenguang Li, Ruijuan Qu, Jianfang Feng, Lianhong Wang
Tetrahydroperfluorocarboxylic acids (2H,2H,3H,3H-PFCAs) have aroused the interest of scholars worldwide due to their potential to generate perfluorinated compounds. In this work, we systematically examined the photodegradation kinetics and mechanisms of typical 2H,2H,3H,3H-PFCAs (Cn F2n+1 C2 H4 COOH, n = 6, 7, 8) in aqueous solution by a 500 W Hg lamp. The photodecomposition of 2H,2H,3H,3H-PFCAs all followed pseudo-first-order kinetics, and the photolysis rate coefficients increased with the increasing carbon chain length...
November 17, 2018: Science of the Total Environment
Shuyu Liu, Renjun Yang, Nuoya Yin, Yuan-Liang Wang, Francesco Faiola
PFOS and PFOA are two of the most abundant perfluorinated compounds (PFCs) in the environment. Previous studies have reported they have a long half-life (up to five years) once they enter into the human body. Moreover, they can potentially promote the adipogenic process by activating PPARγ. However, little is known about PFOS and PFOA chronic health impacts on humans. In this study, we employed primary human mesenchymal stem cells (hMSCs) and demonstrated that PFOS and PFOA exerted acute cytotoxicity and affected adipogenesis and osteogenesis at environmental and human relevant doses...
November 23, 2018: Ecotoxicology and Environmental Safety
Kareem Eldin Mohammed Ahmed, Håvard G Frøysa, Odd André Karlsen, Nello Blaser, Karin Elisabeth Zimmer, Hanne Friis Berntsen, Steven Verhaegen, Erik Ropstad, Ralf Kellmann, Anders Goksøyr
The presence of environmental pollutants in our ecosystem may impose harmful health effects to wildlife and humans. Several of these toxic chemicals have a potential to interfere with the endocrine system. The adrenal cortex has been identified as the main target organ affected by endocrine disrupting chemicals. The aim of this work was to assess exposure effects of defined and environmentally relevant mixtures of chlorinated, brominated and perfluorinated chemicals on steroidogenesis, using the H295R adrenocortical cell line model in combination with a newly developed liquid chromatography tandem mass spectrometry (LC-MS/MS) method...
November 12, 2018: Chemosphere
John W Washington, Charlita G Rosal, Elin M Ulrich, Thomas M Jenkins
Analytical data for ultra-high-performance liquid chromatography (UHPLC), nontargeted, high-resolution, mass-spectrometry (HR/MS) molecular features from a wide array of samples are used to calculate 13 C1 12 C(n-1) /12 Cn isotopologue ratios. These ratios increase with molecular carbon number roughly following a trend defined by atmospheric carbon. When the effective source reservoir 13 C/12 C ratio is calculated from the isotopologue ratio (assuming a fractionation factor of unity), features in biotic samples uniformly are tightly grouped, proximate to atmospheric 13 C/12 C ratio...
November 11, 2018: Journal of Chromatography. A
Benjamin Jeffries, Zhong Wang, Jérôme Graton, Simon D Holland, Thomasin Brind, Ryan D R Greenwood, Jean-Yves Le Questel, James S Scott, Elisabetta Chiarparin, Bruno Linclau
Fluorination is commonly employed to optimize bioactivity and pharmaco-kinetic properties of drug candidates. Aliphatic fluorination often reduces the lipophilicity (log P), but polyfluoroalkylation typically increases lipophilicity. Hence, identification of polyfluorinated motifs that nonetheless lead to similar or even reduced lipophilicities is of interest to expand the arsenal of medicinal chemistry tools in tackling properties such as compound metabolic stability or off-target selectivity. We show that changing a CF3 -group of a perfluoroalkyl chain to a methyl group leads to a drastic reduction in lipophilicity...
November 28, 2018: Journal of Medicinal Chemistry
Ke-Yan Tan, Guo-Hui Lu, Xin Yuan, Yu Zheng, Peng-Wei Shao, Jing-Yi Cai, Yi-Ran Zhao, Xiao-Hua Zhu, Yong-Liang Yang
The Yangtze River drainage basins are China's most important economic development zones and also the locations of several large-scale fluorine chemical industries. In order to reveal the contribution from the tributaries at the dividing point between the middle and lower reaches of the Yangtze River with respect to perfluorinated substances (PFASs), 17 PFAS compounds in surface water, groundwater, and tap water samples were analyzed in the tributary system of the Jiujiang section of the Yangtze River. The total concentrations of PFASs in the surface waters ranged from 7...
November 2018: Bulletin of Environmental Contamination and Toxicology
Hangjun Zhang, Jianbo He, Ning Li, Nana Gao, Qiongxia Du, Bin Chen, Feifei Chen, Xiaodong Shan, Ying Ding, Weiqin Zhu, Yingzhu Wu, Juan Tang, Xiuying Jia
Perfluorooctanoic acid (PFOA) is a perfluorinated compound that is widely distributed, is persistent in the environment, and has a low-level chronic exposure effect on human health. The aim of this study was to investigate the peroxisome proliferator activated receptors γ (PPARγ) and the sterol regulatory element-binding protein 2 (SREBP2) signaling pathways in regulating the lipid damage response to PFOA in the livers of amphibians. Male and female frogs (Rana nigromaculata) were exposed to 0, 0.01, 0.1, 0...
October 4, 2018: Ecotoxicology and Environmental Safety
Patricia López-Arellano, Keila López-Arellano, Jaquelinne Luna, Diana Flores, Javier Jiménez-Salazar, Graciela Gavia, Mario Teteltitla, Juan José Rodríguez, Alejandro Domínguez, Eduardo Casas, Ivan Bahena, Miguel Betancourt, Cristina González, Yvonne Ducolomb, Edmundo Bonilla
Perfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl acid family of compounds. Due to the presence of strong carbon-fluorine bonds, it is practically nonbiodegradable and highly persistent in the environment. PFOA has been detected in the follicular fluid of women, and positively associated with reduced fecundability and infertility. However, there are no reports concerning the experimental evaluation of PFOA on oocyte toxicity in mammals. The aim of the present study was to determine if PFOA is able to induce oxidative stress in fetal ovaries and cause apoptosis in oocytes in vitro...
October 2, 2018: Environmental Toxicology
Concepción Abril, Juan Luis Santos, José Luis Malvar, Julia Martín, Irene Aparicio, Esteban Alonso
A method for the determination of 23 emerging concern pollutants in digested sludge, compost and soil has been developed. Target pollutants include six perfluorinated compounds (5 perfluorocarboxylic acids and perfluorooctanesulfonic acid), the plasticizer bisphenol A, four anionic surfactants (sodium alkylsulfates), four preservatives (parabens), two antimicrobial agents (triclosan and triclocarban) and six UV-filters (benzophenones). Sample treatment was based on ultrasound-assisted extraction with 3 mL of methanol:acetic acid (95:5, v/v) and clean-up by dispersive solid-phase extraction (d-SPE) with C18...
November 16, 2018: Journal of Chromatography. A
Zhen Cheng, Hongcen Dong, Jiaman Liang, Fang Zhang, Xianping Chen, Lingling Du, Kejun Tan
As a kind of emerging persistent organic pollutants, perfluorooctane sulfonate (PFOS) and its salts have caused global ecosystem pollution. To develop rapid, sensitive and low-cost detection method of PFOS is of great importance. In this work, a novel sensing method has been proposed for the highly selective fluorescent visual detection of PFOS in aqueous solution based on carbon dots (CDs) and berberine chloride hydrate (BH). It was found that the fluorescence of CDs decreased apparently in the presence of berberine chloride hydrate in pH 6...
January 15, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
L E Ikkere, I Perkons, J Sire, I Pugajeva, V Bartkevics
The occurrence of polybrominated diphenyl ethers (PBDE), perfluorinated compounds (PFC), and nonsteroidal anti-inflammatory drugs (NSAID) in Latvian freshwater ecosystems was evaluated by using filter-feeding mussels as bioindicators. Twenty four samples of mussels were collected from freshwater bodies throughout the territory of Latvia during the summer of 2017. PBDE contamination was ubiquitous, reaching the highest total concentration of 193.2 pg g-1 w.w. BDE-209 was the most abundant compound, followed by penta-BDE components BDE-49, -100, -99, -153, -154, and -47 in decreasing order...
December 2018: Chemosphere
Aneta Wójcik, Paulina Perczyk, Paweł Wydro, Marcin Broniatowski
Water soluble perfluorinated compounds (PFCs) as perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) and their shorter chain homologues are persistent organic pollutants widely distributed in the environment. PFCs accumulate in soils and sediments and because of their toxicity endanger the decomposer organisms. PFCs are toxic to a wide spectrum of soil bacteria and their biocide activity was related with their membrane activity; however, the exact mechanism of PFCs - bacterial membrane interactions is unknown...
December 2018: Biochimica et biophysica acta. Biomembranes
Megan Steele, Converse Griffith, Christin Duran
Large-scale manufacturing of poly- and perfluorinated compounds in the second half of the 20th century has led to their ubiquity in the environment, and their unique structure has made them persistent contaminants. A recent drinking water advisory level issued by the United States Environmental Protection Agency lowered the advisory level concentration of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) from 200 nanograms per liter and 400 nanograms per liter, respectively, to 70 nanograms per liter separately or combined...
September 14, 2018: Toxics
Yifei Liu, Lin Ma, Qing Yang, Guanghe Li, Fang Zhang
Perfluorinated compounds (PFCs) in groundwater are of widespread concern due to their potential toxicity to human health and ecological systems. PFCs in rivers can infiltrate into groundwater through riverbank infiltration, potentially endangering the safety of drinking water and causing a deterioration in the groundwater environment. This study investigated the occurrence of PFCs in rivers and riverside groundwater from 2014 to 2017 in a city in north China. PFCs were detected in most of the groundwater samples, ranging from not detected to 64...
November 2018: Chemosphere
Caterina Ledda, Giuseppe La Torre, Diana Cinà, Gianluca Paravizzini, Ermanno Vitale, Piero Pavone, Ivo Iavicoli, Venerando Rapisarda
Perfluorinated compounds (PFCs) are a large group of man-made chemicals characterized by a completely fluorinated hydrophobic linear carbon chain attached to a hydrophilic head. The presence of PFCs has been related with various adverse effects on several organs and systems. 61 children (6-11 years of age) living in Sicily underwent medical examination and blood and urine routinary tests, as well as the serum concentration of 16 PFCs. These compounds (∑PFCs = 5.888 ng/mL, range 1.035-12.94 ng/mL) were widely detected in the samples of all children, showing that they had been extensively exposed to PFCs, especially perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonate (PFHxs) and perfluorodecanoic acid (PFDA)...
December 1, 2018: Toxicology Letters
John W Stanifer, Heather M Stapleton, Tomokazu Souma, Ashley Wittmer, Xinlu Zhao, L Ebony Boulware
BACKGROUND AND OBJECTIVES: Per- and polyfluoroalkyl substances (PFASs) are a large group of manufactured nonbiodegradable compounds. Despite increasing awareness as global pollutants, the impact of PFAS exposure on human health is not well understood, and there are growing concerns for adverse effects on kidney function. Therefore, we conducted a scoping review to summarize and identify gaps in the understanding between PFAS exposure and kidney health. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We systematically searched PubMed, EMBASE, EBSCO Global Health, World Health Organization Global Index, and Web of Science for studies published from 1990 to 2018...
October 8, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Khaled Abass, Anastasia Emelyanova, Arja Rautio
The first Arctic Monitoring and Assessment Programme (AMAP) report was published in 1998 and followed by three assessment reports of human health (AMAP 2003, 2009 and 2015). The focus area of the AMAP reports was to monitor levels of environmental contaminants in the Arctic and to assess the health effects connected with detected levels in Arctic countries. This review gives an overview of temporal trends of contaminants and their health effects in humans of the Arctic based on data published by AMAP, as well as Russian scientific literature...
October 2018: Environmental Science and Pollution Research International
Xiaojian Shao, Fenfen Ji, Yawei Wang, Lin Zhu, Zhen Zhang, Xiubo Du, Arthur Chi Kong Chung, Yanjun Hong, Qian Zhao, Zongwei Cai
Identification of the direct molecular targets of environmental pollutants is of great importance for toxicity mechanism studies. Despite numerous studies have been conducted to investigate the toxicity mechanism of perfluorinated compounds (PFCs), their direct-binding protein targets which trigger downstream toxicity effects remain largely unknown. Herein, we present a systematic chemical proteomic study to profile the target proteins of PFCs by taking PFOA as a representative. Considering its electrophilicity, PFOA could preferentially bind to reactive cysteine-containing proteins...
September 18, 2018: Analytical Chemistry
Charles E Schaefer, Sarah Choyke, P Lee Ferguson, Christina Andaya, Aniela Burant, Andrew Maizel, Timothy J Strathmann, Christopher P Higgins
While oxidative technologies have been proposed for treatment of waters impacted by aqueous film forming foams (AFFFs), information is lacking regarding the transformation pathways for the chemical precursors to the perfluoroalkyl acids (PFAAs) typically present in such waters. This study examined the oxidative electrochemical treatment of poly- and perfluoroalkyl substances (PFASs) for two AFFF-impacted groundwaters. The bulk pseudo first order rate constant for PFOA removal was 0.23 L h-1 A-1 ; for PFOS, this value ranged from 0...
September 18, 2018: Environmental Science & Technology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"