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perfluorinated compounds

Ke-Yan Tan, Guo-Hui Lu, Xin Yuan, Yu Zheng, Peng-Wei Shao, Jing-Yi Cai, Yi-Ran Zhao, Xiao-Hua Zhu, Yong-Liang Yang
The Yangtze River drainage basins are China's most important economic development zones and also the locations of several large-scale fluorine chemical industries. In order to reveal the contribution from the tributaries at the dividing point between the middle and lower reaches of the Yangtze River with respect to perfluorinated substances (PFASs), 17 PFAS compounds in surface water, groundwater, and tap water samples were analyzed in the tributary system of the Jiujiang section of the Yangtze River. The total concentrations of PFASs in the surface waters ranged from 7...
October 8, 2018: Bulletin of Environmental Contamination and Toxicology
Hangjun Zhang, Jianbo He, Ning Li, Nana Gao, Qiongxia Du, Bin Chen, Feifei Chen, Xiaodong Shan, Ying Ding, Weiqin Zhu, Yingzhu Wu, Juan Tang, Xiuying Jia
Perfluorooctanoic acid (PFOA) is a perfluorinated compound that is widely distributed, is persistent in the environment, and has a low-level chronic exposure effect on human health. The aim of this study was to investigate the peroxisome proliferator activated receptors γ (PPARγ) and the sterol regulatory element-binding protein 2 (SREBP2) signaling pathways in regulating the lipid damage response to PFOA in the livers of amphibians. Male and female frogs (Rana nigromaculata) were exposed to 0, 0.01, 0.1, 0...
October 4, 2018: Ecotoxicology and Environmental Safety
Patricia López-Arellano, Keila López-Arellano, Jaquelinne Luna, Diana Flores, Javier Jiménez-Salazar, Graciela Gavia, Mario Teteltitla, Juan José Rodríguez, Alejandro Domínguez, Eduardo Casas, Ivan Bahena, Miguel Betancourt, Cristina González, Yvonne Ducolomb, Edmundo Bonilla
Perfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl acid family of compounds. Due to the presence of strong carbon-fluorine bonds, it is practically nonbiodegradable and highly persistent in the environment. PFOA has been detected in the follicular fluid of women, and positively associated with reduced fecundability and infertility. However, there are no reports concerning the experimental evaluation of PFOA on oocyte toxicity in mammals. The aim of the present study was to determine if PFOA is able to induce oxidative stress in fetal ovaries and cause apoptosis in oocytes in vitro...
October 2, 2018: Environmental Toxicology
Concepción Abril, Juan Luis Santos, José Luis Malvar, Julia Martín, Irene Aparicio, Esteban Alonso
A method for the determination of 23 emerging concern pollutants in digested sludge, compost and soil has been developed. Target pollutants include six perfluorinated compounds (5 perfluorocarboxylic acids and perfluorooctanesulfonic acid), the plasticizer bisphenol A, four anionic surfactants (sodium alkylsulfates), four preservatives (parabens), two antimicrobial agents (triclosan and triclocarban) and six UV-filters (benzophenones). Sample treatment was based on ultrasound-assisted extraction with 3 mL of methanol:acetic acid (95:5, v/v) and clean-up by dispersive solid-phase extraction (d-SPE) with C18...
September 17, 2018: Journal of Chromatography. A
Zhen Cheng, Hongcen Dong, Jiaman Liang, Fang Zhang, Xianping Chen, Lingling Du, Kejun Tan
As a kind of emerging persistent organic pollutants, perfluorooctane sulfonate (PFOS) and its salts have caused global ecosystem pollution. To develop rapid, sensitive and low-cost detection method of PFOS is of great importance. In this work, a novel sensing method has been proposed for the highly selective fluorescent visual detection of PFOS in aqueous solution based on carbon dots (CDs) and berberine chloride hydrate (BH). It was found that the fluorescence of CDs decreased apparently in the presence of berberine chloride hydrate in pH 6...
September 17, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
L E Ikkere, I Perkons, J Sire, I Pugajeva, V Bartkevics
The occurrence of polybrominated diphenyl ethers (PBDE), perfluorinated compounds (PFC), and nonsteroidal anti-inflammatory drugs (NSAID) in Latvian freshwater ecosystems was evaluated by using filter-feeding mussels as bioindicators. Twenty four samples of mussels were collected from freshwater bodies throughout the territory of Latvia during the summer of 2017. PBDE contamination was ubiquitous, reaching the highest total concentration of 193.2 pg g-1 w.w. BDE-209 was the most abundant compound, followed by penta-BDE components BDE-49, -100, -99, -153, -154, and -47 in decreasing order...
December 2018: Chemosphere
Aneta Wójcik, Paulina Perczyk, Paweł Wydro, Marcin Broniatowski
Water soluble perfluorinated compounds (PFCs) as perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA) and their shorter chain homologues are persistent organic pollutants widely distributed in the environment. PFCs accumulate in soils and sediments and because of their toxicity endanger the decomposer organisms. PFCs are toxic to a wide spectrum of soil bacteria and their biocide activity was related with their membrane activity; however, the exact mechanism of PFCs - bacterial membrane interactions is unknown...
September 21, 2018: Biochimica et biophysica acta. Biomembranes
Megan Steele, Converse Griffith, Christin Duran
Large-scale manufacturing of poly- and perfluorinated compounds in the second half of the 20th century has led to their ubiquity in the environment, and their unique structure has made them persistent contaminants. A recent drinking water advisory level issued by the United States Environmental Protection Agency lowered the advisory level concentration of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) from 200 nanograms per liter and 400 nanograms per liter, respectively, to 70 nanograms per liter separately or combined...
September 14, 2018: Toxics
Yifei Liu, Lin Ma, Qing Yang, Guanghe Li, Fang Zhang
Perfluorinated compounds (PFCs) in groundwater are of widespread concern due to their potential toxicity to human health and ecological systems. PFCs in rivers can infiltrate into groundwater through riverbank infiltration, potentially endangering the safety of drinking water and causing a deterioration in the groundwater environment. This study investigated the occurrence of PFCs in rivers and riverside groundwater from 2014 to 2017 in a city in north China. PFCs were detected in most of the groundwater samples, ranging from not detected to 64...
November 2018: Chemosphere
Caterina Ledda, Giuseppe La Torre, Diana Cinà, Gianluca Paravizzini, Ermanno Vitale, Piero Pavone, Ivo Iavicoli, Venerando Rapisarda
Perfluorinated compounds (PFCs) are a large group of man-made chemicals characterized by a completely fluorinated hydrophobic linear carbon chain attached to a hydrophilic head. The presence of PFCs has been related with various adverse effects on several organs and systems. 61 children (6-11 years of age) living in Sicily underwent medical examination and blood and urine routinary tests, as well as the serum concentration of 16 PFCs. These compounds (∑PFCs = 5.888 ng/mL, range 1.035-12.94 ng/mL) were widely detected in the samples of all children, showing that they had been extensively exposed to PFCs, especially perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonate (PFHxs) and perfluorodecanoic acid (PFDA)...
September 11, 2018: Toxicology Letters
John W Stanifer, Heather M Stapleton, Tomokazu Souma, Ashley Wittmer, Xinlu Zhao, L Ebony Boulware
BACKGROUND AND OBJECTIVES: Per- and polyfluoroalkyl substances (PFASs) are a large group of manufactured nonbiodegradable compounds. Despite increasing awareness as global pollutants, the impact of PFAS exposure on human health is not well understood, and there are growing concerns for adverse effects on kidney function. Therefore, we conducted a scoping review to summarize and identify gaps in the understanding between PFAS exposure and kidney health. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We systematically searched PubMed, EMBASE, EBSCO Global Health, World Health Organization Global Index, and Web of Science for studies published from 1990 to 2018...
September 13, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Khaled Abass, Anastasia Emelyanova, Arja Rautio
The first Arctic Monitoring and Assessment Programme (AMAP) report was published in 1998 and followed by three assessment reports of human health (AMAP 2003, 2009 and 2015). The focus area of the AMAP reports was to monitor levels of environmental contaminants in the Arctic and to assess the health effects connected with detected levels in Arctic countries. This review gives an overview of temporal trends of contaminants and their health effects in humans of the Arctic based on data published by AMAP, as well as Russian scientific literature...
October 2018: Environmental Science and Pollution Research International
Xiaojian Shao, Fenfen Ji, Yawei Wang, Lin Zhu, Zhen Zhang, Xiubo Du, Arthur Chi Kong Chung, Yanjun Hong, Qian Zhao, Zongwei Cai
Identification of the direct molecular targets of environmental pollutants is of great importance for toxicity mechanism studies. Despite numerous studies have been conducted to investigate the toxicity mechanism of perfluorinated compounds (PFCs), their direct-binding protein targets which trigger downstream toxicity effects remain largely unknown. Herein, we present a systematic chemical proteomic study to profile the target proteins of PFCs by taking PFOA as a representative. Considering its electrophilicity, PFOA could preferentially bind to reactive cysteine-containing proteins...
September 18, 2018: Analytical Chemistry
Charles E Schaefer, Sarah Choyke, P Lee Ferguson, Christina Andaya, Aniela Burant, Andrew Maizel, Timothy J Strathmann, Christopher P Higgins
While oxidative technologies have been proposed for treatment of waters impacted by aqueous film forming foams (AFFFs), information is lacking regarding the transformation pathways for the chemical precursors to the perfluoroalkyl acids (PFAAs) typically present in such waters. This study examined the oxidative electrochemical treatment of poly- and perfluoroalkyl substances (PFASs) for two AFFF-impacted groundwaters. The bulk pseudo first order rate constant for PFOA removal was 0.23 L h-1 A-1 ; for PFOS, this value ranged from 0...
September 18, 2018: Environmental Science & Technology
Mohammad Hadi Zarei, Seyed Farshad Hosseini Shirazi, Marjan Aghvami, Jalal Pourahmad
Perfluorinated compounds (PFCs) such as perfluorooctanesulfonate (PFOS) are stable chemicals that accumulate in biological matrix. Toxicity of these compounds including immunotoxicity has been demonstrated in experimental models and wildlife. Although limited number of studies examined the effects of PFOS on human lymphocytes but so far no research has investigated the complete mechanisms of PFOS cytotoxicity toward human lymphocytes. The main goal of this investigation was to find out the mechanisms underlying the cytotoxic effect of PFOS toward human lymphocytes using accelerated cytotoxicity mechanisms screening (ACMS) technique...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Qian Xiang, Guoqiang Shan, Wei Wu, Hangbiao Jin, Lingyan Zhu
Accurate measuring n-octanol/water partition coefficients (log Kow ) of perfluoroalkyl carboxylic acids (PFCAs) using experimental approach has been proven to be very difficult due to their special properties. The ionizable carboxyl groups in PFCAs make their log Kow dependent on pH. In this study, the log Kow values of neutral species of PFCAs (C4≤n≤14 ) were measured based on reversed-phase high-performance liquid chromatography (RP-HPLC) with the mobile phase pH varying in the range of 1.09-5.00. The relationship between log Kow and retention times was established using some reference compounds (including agrochemicals, polycyclic aromatic hydrocarbons) with known log Kow values, and then validated with alkyl fatty acids, which have similar chemical structures as PFCAs...
November 2018: Environmental Pollution
Qing Ye, Zongbao Chen
In this work, a new method was developed for perfluorinated compounds (PFCs) analysis in water samples based on decyl-perfluorinated magnetic mesoporous nanocomposites microspheres-assisted extraction and microwave-assisted derivatization followed by gas chromatography-mass spectrometry analysis. The decyl-perfluorinated magnetic mesoporous nanocomposites have several advantages such as fast separation ability, good dispersibility in water sample and high selective preconcentration of PFCs. Various parameters, including eluting solvent and volume, the amounts of absorbents, extraction time and elution time, the microwave-assisted derivatization conditions were optimized...
July 31, 2018: Journal of Chromatographic Science
Yang Song, Xu Yan, Grayson Ostermeyer, Suiqiong Li, Lingbo Qu, Dan Du, Zhaohui Li, Yuehe Lin
Intracellular miRNA detection is vitally important for diagnosing severe diseases like cancer and for resolving the ensemble of gene products that orchestrate the living state of cells. Recent advances in the design, synthesis, and application of biocompatible nanomaterials as platforms for probing miRNAs have enabled widespread efforts to mobilize new compounds in biomedical research. Two-dimensional graphene-like nanomaterials exhibit desirable physical properties such as convenient quantum size and dynamic interface functionality...
September 4, 2018: Analytical Chemistry
Gaoshuo Jiang, Liqiang Luo, Lu Tan, Jinliang Wang, Shenxiang Zhang, Feng Zhang, Jian Jin
Superhydrophobic membranes with extreme liquid water repellency property are good candidates for waterproof and breathable application. Different from the mostly used strategies through either mixing or postmodifying base membranes with perfluorinated compounds, we report in this work a facile methodology to fabricate superhydrophobic microporous membranes made up of pure poly(vinylidene fluoride) (PVDF) via a high-humidity induced electrospinning process. The superhydrophobic property of the PVDF microporous membrane is contributed by its special microsphere-fiber interpenetrated rough structure...
August 22, 2018: ACS Applied Materials & Interfaces
Heeju Choi, In-Ae Bae, Jae Chun Choi, Se-Jong Park, MeeKyung Kim
Perfluorinated compounds (PFCs) are used in manufacturing food contact materials, including non-stick cookware coatings and oil- and moisture-resistant paper coatings. The chemical stability of PFCs poses an issue for human safety, as they do not degrade well naturally and hence may accumulate in the body. In terms of food safety, since dietary intake is thought to be a major source of exposure to PFCs, it is necessary to assess the migration of PFCs from food packaging articles to food under typical cooking and storage conditions...
August 10, 2018: Food Additives & Contaminants. Part B, Surveillance
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