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ovarian granulosa cell

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https://www.readbyqxmd.com/read/30515820/evaluation-of-ovarian-cancer-risk-in-granulosa-cells-treated-with-steroid-depleted-endometriosis-serum-role-of-nf-%C3%AE%C2%BAb-rela-and-akt
#1
Samira Asghari, Amir Valizadeh Dizajeykan, Majid Ahmadi, Abolfazl Barzegari, Reza Rikhtegar, Sanam Dolati, Shahla Danaii, Sedigheh Abdollahi-Fard, Mohammad Nouri, Mahdi Mahdipour, Mehdi Yousefi
BACKGROUND: Despite at the beginning known as a benign disease, endometriosis is defined as a risk factor for developing ovarian carcinoma. The effect of endometriosis on ovarian malignancy is known but its role in granulosa cell tumor is still unclear. METHODS AND MATERIALS: In this study, serum samples were collected from patients with endometriosis and divided into whole and steroid-depleted groups. Desertification was performed according to the charcoal-dextran protocol and sera were added to the culture media of granulosa cells retrieved from tubal or male factor infertile women...
December 4, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30503199/follicular-fluid-humanin-concentration-is-related-to-ovarian-reserve-markers-and-clinical-pregnancy-after-ivf-icsi-a-pilot-study
#2
Meng Rao, Fang Zhou, Li Tang, Zhengyan Zeng, Shifu Hu, Yingying Wang, Dandan Ke, Guiping Cheng, Wei Xia, Ling Zhang, Changhong Zhu
RESEARCH QUESTION: Is humanin present in the human ovary and follicular fluid? What relationship exists between humanin concentration in the follicular fluid and ovarian reserve and clinical outcomes after IVF and intracytoplasmic sperm injection (ICSI)? DESIGN: Follicular fluid samples were collected from 179 patients undergoing their first IVF or ICSI cycle during oocyte retrieval. Ovarian tissues were collected from two patients undergoing surgery for ovarian cysts...
November 23, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/30503129/growth-hormone-during-in-vitro-fertilization-in-older-women-modulates-the-density-of-receptors-in-granulosa-cells-with-improved-pregnancy-outcomes
#3
Sheena L P Regan, Phil G Knight, John L Yovich, Frank Arfuso, Arun Dharmarajan
OBJECTIVE: To study the effect of aging and granulosa cell growth hormone receptor (GHR) expression, and the effect of growth hormone (GH) co-treatment during IVF on receptor expression. DESIGN: Laboratory study. SETTING: University. PATIENT(S): A total of 445 follicles were collected from 62 women undergoing standard infertility treatment. INTERVENTION(S): Preovulatory ovarian follicle biopsies of granulosa cells and follicular fluid...
December 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/30500284/ovarian-sex-cord-stromal-tumors-reflections-on-a-40-year-experience-with-a-fascinating-group-of-tumors-including-comments-on-the-seminal-observations-of-robert-e-scully-md
#4
Robert H Young
CONTEXT.—: This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, MD, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area. OBJECTIVE.—: To review ovarian sex cord-stromal tumors. DATA SOURCES.—: Literature and personal experience. CONCLUSIONS...
December 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/30498475/atf4-contributes-to-ovulation-via-regulating-cox2-pge2-expression-a-potential-role-of-atf4-in-pcos
#5
Fangfang Di, Jiansheng Liu, Shang Li, Guangxin Yao, Yan Hong, Zi-Jiang Chen, Weiping Li, Yanzhi Du
Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not explored. The present study investigated the role of ATF4 in ovarian ovulatory function. Human granulosa cells (hGCs) from 48 women newly diagnosed with PCOS and 37 controls were used to determine ATF4 expression. In vitro cultured hGCs were used to detect the upstream and downstream genes of ATF4...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30496379/ovulation-parallels-with-inflammatory-processes
#6
Diane M Duffy, CheMyong Ko, Misung Jo, Mats Brannstrom, Thomas E Curry
The midcycle surge of luteinizing hormone (LH) sets in motion interconnected networks of signaling cascades to bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators of these LH-induced signaling cascades are associated with inflammation, leading to the postulate that ovulation is similar to an inflammatory response. First responders to the LH surge are granulosa and theca cells, which produce steroids, prostaglandins, chemokines, and cytokines, which are also mediators of inflammatory processes...
November 28, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/30487754/vitamin-d3-regulates-follicular-development-and-intrafollicular-vitamin-d-biosynthesis-and-signaling-in-the-primate-ovary
#7
Jing Xu, Maralee S Lawson, Fuhua Xu, Yongrui Du, Olena Y Tkachenko, Cecily V Bishop, Lucas Pejovic-Nezhat, David B Seifer, Jon D Hennebold
There is an increasing recognition that vitamin D plays important roles in female reproduction. Recent studies demonstrated that 1α,25-dihydroxyvitamin D3 (VD3), the biologically active form of vitamin D, improved ovarian follicle survival and growth in vitro . Therefore, we investigated the direct effects of VD3 at the specific preantral and antral stages of follicular development, and tested the hypothesis that vitamin D receptor (VDR) and enzymes critical for vitamin D biosynthesis are expressed in the primate ovary...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30485710/imprint-cytology-of-strumal-carcinoid-of-the-ovary-a-case-report-with-immunocytochemical-analysis
#8
Mitsuaki Ishida, Tomoko Arimoto, Kaori Sandoh, Kimiaki Okano, Yusuke Ebisu, Hiroko Ito, Mio Matsumoto, Tomomi Mizokami, Masato Kita, Hidetaka Okada, Koji Tsuta
Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the left ovary, and bilateral salpingo-oophorectomy was performed. The Papanicolaou smear of the imprint cytological specimen of the left ovarian tumor revealed presence of two distinct components. The first component included thyroid follicles, which was composed of flat sheets of polygonal epithelial cells without nuclear groove and intranuclear inclusion...
November 28, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/30483787/expression-of-fkbp52-in-the-ovaries-of-pcos-rats
#9
Shiyan Song, Yong Tan
The present study aimed to examine the expression of FK‑506 binding protein 52 (FKBP52) in the ovary tissues of rats with polycystic ovarian syndrome (PCOS) and its action on mediating androgen receptor (AR) through the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (ERK) pathway. PCOS model rats were established by dehydroepiandrosterone injection. Enzyme‑linked immunosorbent assay (ELISA) measured serum sex hormones. Hematoxylin and eosin (H&E) staining was used to examine histological changes of the ovarian tissues...
November 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30478915/comparative-transcriptome-analysis-reveals-perp-upregulated-during-salmonella-enteritidis-challenge-in-laying-ducks
#10
Yu Zhang, Tian-Tian Gu, Yang Chen, Yu Huang, Jinping Du, Lizhi Lu, Guo-Qiang Zhu, Qi Xu, Guo-Hong Chen
Salmonella Enteritidis (SE) can be transmitted to eggs through cecum or the ovary from infected layers and causes food poisoning in humans. The mechanism of cecal transmission has been extensively studied. However, the mechanism and route of transovarian transmission of SE remain unclear. In this study, the ducks were orally inoculated with SE, and the ovarian follicles and stroma were collected to detect SE infection. The immune responses were triggered and the innate and adaptive immune genes (TLR4, NOD1, AvβD7, and IL-1β) were upregulated significantly during the SE challenge...
November 27, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30476103/insulin-reduces-reaction-of-follicular-granulosa-cell-to-fsh-stimulation-in-obesity-related-infertility-women-during-ivf
#11
Pei Xu, Bao-Yi Huang, Jia-Hui Zhan, Man-Ting Liu, Yang Fu, You-Qiang Su, Qing-Yuan Sun, Wei-Hua Wang, Dun-Jin Chen, Jian-Qiao Liu
Context: Obese women usually need larger doses of FSH for ovarian stimulation, resulting in poor outcomes; however, the mechanism is still unclear. Objective: To investigate the molecular regulation of FSH receptor (FSHR) expression associated with obesity. Design: Case-control study to improve IVF outcomes. Patients: Eighty-two obese and 457 overweight women undergoing IVF and 1,790 age-matched controls with normal weight from our reproductive medicine center...
November 21, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30472193/transcriptome-landscape-of-human-folliculogenesis-reveals-oocyte-and-granulosa-cell-interactions
#12
Yaoyao Zhang, Zhiqiang Yan, Qingyuan Qin, Vicki Nisenblat, Hsun-Ming Chang, Yang Yu, Tianren Wang, Cuiling Lu, Ming Yang, Shuo Yang, Ying Yao, Xiaohui Zhu, Xi Xia, Yujiao Dang, Yixin Ren, Peng Yuan, Rong Li, Ping Liu, Hongyan Guo, Jinsong Han, Haojie He, Kun Zhang, Yiting Wang, Yu Wu, Meng Li, Jie Qiao, Jie Yan, Liying Yan
The dynamic transcriptional regulation and interactions of human germlines and surrounding somatic cells during folliculogenesis remain unknown. Using RNA sequencing (RNA-seq) analysis of human oocytes and corresponding granulosa cells (GCs) spanning five follicular stages, we revealed unique features in transcriptional machinery, transcription factor networks, and reciprocal interactions in human oocytes and GCs that displayed developmental-stage-specific expression patterns. Notably, we identified specific gene signatures of two cell types in particular developmental stage that may reflect developmental competency and ovarian reserve...
November 15, 2018: Molecular Cell
https://www.readbyqxmd.com/read/30472065/protective-effects-of-trehalose-on-frozen-thawed-ovarian-granulosa-cells-of-cattle
#13
Y X Zheng, L Z Ma, S J Liu, C T Zhang, R Meng, Y Z Chen, Z L Jiang
In this study, trehalose was investigated for its cryoprotective effects on ovarian granulosa cells (bGCs) of cattle. Five concentrations of trehalose at 0, 0.2, 0.4, 0.6 and 0.8 mol/L were added to the cryopreservation medium of bGCs, and the effects on the quality of frozen-thawed bGCs were assessed. The results indicate that the use of cryopreservation medium containing 0.2 and 0.4 mol/L of trehalose resulted in a greater rate of bGC viability compared to those of other groups (P<0.05). Culturing with trehalose at 0...
November 15, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/30470961/effect-of-intra-ovarian-injection-of-mesenchymal-stem-cells-in-aged-mares
#14
Sicilia T Grady, Ashlee E Watts, James A Thompson, M Cecilia T Penedo, Kranti Konganti, Katrin Hinrichs
PURPOSE: This study aims to determine if intra-ovarian injection of bone marrow-derived mesenchymal stem cells (MSCs) improves or restores ovarian function in aged females. METHODS: Prospective randomized study of eight aged mares and six young mares receiving intra-ovarian injection of MSCs or vehicle. Main outcome measures were antral follicle count and serum anti-Müllerian hormone (AMH) (aged and young mares), and for aged mares, oocyte meiotic and developmental competence; gross and histological ovarian assessment; evaluation of presence of chimerism in recovered granulosa cells and in ovarian tissue samples; and gene expression in ovarian tissue as assessed by RNA sequencing...
November 23, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/30465009/gastric-metastasis-of-an-ovarian-granulosa-cell-tumor-diagnosed-in-a-patient-with-worsening-reflux
#15
Jagpal S Klair, Kaartik Soota, Aditi Vidholia, Caryn M Berkowitz
No abstract text is available yet for this article.
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/30460113/the-effects-of-mouse-ovarian-granulosa-cell-function-and-related-gene-expression-by-suppressing-bmp-smad-signaling-pathway
#16
Li Zhang, Hejian Wang, Daolun Yu, Jie Chen, Chaofeng Xing, Jie Li, Jun Li, Yafei Cai
BMP I type receptor inhibitor can selectively inhibit BMP/Smad signaling pathways, mainly by inhibiting the BMP I type receptor activity to prevent phosphorylation of Smad1, Smad5 and Smad9. The aim of the present study was to explore the effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway with LDN-193189(A type of BMP I type receptor inhibitor). In this study, we cultivate the original generation of mouse ovarian granular cells then collect cells and cell culture medium after treatment...
2018: Animal Cells and Systems
https://www.readbyqxmd.com/read/30456817/brain-derived-neurotrophic-factor-promotes-proliferation-and-progesterone-synthesis-in-bovine-granulosa-cells
#17
Shuxiong Chen, Fengge Wang, Zhuo Liu, Yun Zhao, Yanwen Jiang, Lu Chen, Chunjin Li, Xu Zhou
Brain-derived neurotrophic factor (BDNF) is involved in regulating the growth of ovarian follicles, maturation of the oocyte, and development of the early embryo through its receptor, tyrosine kinase receptor B (TrkB). However, it is still unclear as to how BDNF influences proliferation and steroidogenesis of bovine granulosa cells (GCs). In this paper, we confirmed that BDNF and TrkB were expressed in bovine GCs, and that proliferation and steroidogenesis by bovine GCs were reduced by knockdown of BDNF or inhibition of TrkB...
November 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30456286/association-between-diabetes-mellitus-and-progression-free-survival-in-women-with-ovarian-granulosa-cell-tumors
#18
Joan R Tymon-Rosario, Eirwen M Miller, Gregory M Gressel, Nicole S Nevadunsky
•Diabetes mellitus confers worse survival in women with granulosa cell tumors.•Routine lymphadenectomy does not improve survival in women with granulosa cell tumors.•Women in this cohort had a high prevalence of concurrent breast cancer.•Further studies are needed to see if glycemic control improves survival outcomes.
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30453069/identification-of-micrornas-in-granulosa-cells-from-patients-with-different-levels-of-ovarian-reserve-function-and-the-potential-regulatory-function-of-mir-23a-in-granulosa-cell-apoptosis
#19
Haining Luo, Ying Han, Jiao Liu, Yunshan Zhang
This study aimed to determine the microRNA (miRNA) profiles in granulosa cells (GCs) from the follicular fluid (FF) of patients with varying levels of ovarian reserve function. We included 45 women undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment. After collecting GCs from each patient, total RNA was extracted from 12 samples. Using Illumina/deep-sequencing technology, we analyzed the small RNAs in each group. Using the R package, we identified the differentially expressed (DE) miRNAs among patients with varying levels of ovarian reserve function...
November 16, 2018: Gene
https://www.readbyqxmd.com/read/30451825/loss-of-oocyte-rps26-in-mice-arrests-oocyte-growth-and-causes-premature-ovarian-failure
#20
Xiao-Man Liu, Ming-Qi Yan, Shu-Yan Ji, Qian-Qian Sha, Tao Huang, Han Zhao, Hong-Bin Liu, Heng-Yu Fan, Zi-Jiang Chen
Global transcriptional activity increases as oocytes grow and is silenced in fully grown oocytes. Thus, the chromatin configuration varies during oocyte growth, but the molecular mechanisms regulating these changes remain to be clarified. Here, we studied a susceptibility gene of polycystic ovary syndrome (PCOS), RPS26, which is a ribosomal protein-encoding gene that is highly expressed in the ovary, but the functions of which remain unknown. Specific knockout of Rps26 in mouse oocytes resulted in retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes were arrested at the transition from the non-surrounded nucleolus (NSN) to surrounded nucleolus (SN)-type...
November 19, 2018: Cell Death & Disease
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