Do-Sung Kim, Hwa-Young Lee, Hwa-Jin Kim, Geum-Hwa Lee, Young Jae Lim, Bo Mi Ko, Ji-Hyun Kim, Tae Won Kim, Hye Kyung Kim, Tae Young Kim, Dae Il Hwang, Ha Kyoung Choi, Seon Min Ju, Myung Ja Chung, Han-Jung Chae
Mori Folium ( Morus alba leaf, MF) and Mori Cortex Radicis ( Morus alba root cortex, MR) have been studied for their anti-obesity effects by enhancing the browning process and inhibiting adipogenesis. However, important aspects of their protective mechanisms have not been thoroughly investigated, which could aid in developing functional food. Thus, this study aims to determine the synergistic effects of MF and MR against obesity and its associated mechanisms. In an in vitro cell culture model of brown adipocytes, a 1:1 mixture of MF and MR showed a synergistic effect on the expression of brown adipocyte-specific genes, including Ucp-1 , Ppargc1a , Cbp/p300-interacting transactivator ( Cited ), Prdm16 , Tbx1 , and Fgf21 compared with either MF- or MR-treated conditions...
August 24, 2023: Nutrients