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microvascular density

Jacqueline Chua, Calvin Woon Loong Chin, Jimmy Hong, Miao Li Chee, Thu-Thao Le, Daniel Shu Wei Ting, Tien Yin Wong, Leopold Schmetterer
OBJECTIVE: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure (BP) and renal parameters. METHODS: This observational cross-sectional study consisted of 153 normal eyes from 77 nondiabetic hypertensive adults [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]...
August 14, 2018: Journal of Hypertension
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage...
August 14, 2018: Scientific Reports
Michel Hermans, Sylvie Ahn, Michel Rousseau
BACKGROUND: To establish the isolated and crossed impacts of familial histories (FH) of early-onset coronary heart disease (EOCHD) and type 2 diabetes mellitus (T2DM) on their diabetic offsprings. METHODS: The cardiometabolic phenotype of 1098 T2DM patients was analysed according to FHs of DM and/or EOCHD, including body composition, fasting insulinemia, insulin sensitivity, β-cell function (BCF), lipids, lipoprotein(a), high-density lipoprotein (HDL) number/functionality, and micro-/macrovascular complications...
August 13, 2018: Journal of Diabetes
Guido Carpino, Vincenzo Cardinale, Trine Folseraas, Diletta Overi, Krzysztof Grzyb, Daniele Costantini, Pasquale Bartolomeo Berloco, Sabina Di Matteo, Tom Hemming Karlsen, Domenico Alvaro, Eugenio Gaudio
Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy frequently complicated by cholangiocarcinoma (CCA). Massive proliferation of biliary tree stem/progenitor cells (BTSCs), expansion of peribiliary glands (PBGs), and dysplasia were observed in PSC. The aims of the present study were to evaluate the involvement of PBGs and BTSCs in CCA which emerged in PSC patients. Specimens from normal liver (N=5), PSC (N=20), and PSC-associated CCA (N=20) were included. Samples were processed for histology, immunohistochemistry and immunofluorescence...
August 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
William Robert Kwapong, Hua Ye, Chenlei Peng, Xiran Zhuang, Jianhua Wang, Meixiao Shen, Fan Lu
Purpose: To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find a correlation between the microvascular impairment and the neuronal damage. Methods: This is a prospective, observational study including 49 eyes from 38 PD patients in their early stages and 34 eyes from 28 healthy controls with comparable age range. Macula microvasculature was evaluated with the spectral-domain optical coherence tomography (SD-OCT) angiography and intraretinal layer thickness evaluated with the SD-OCT...
August 1, 2018: Investigative Ophthalmology & Visual Science
Liang Hu, Ce Shi, Hong Jiang, Yingying Shi, Zubin Sethi, Jianhua Wang
Purpose: To investigate the factors affecting microvascular responses in the bulbar conjunctiva of habitual contact lens (HCL) wearers. Methods: A functional slit-lamp biomicroscope (FSLB) was used to image the temporal bulbar conjunctiva of habitual contact lens (HCL) wearers and non-contact lens (NCL) wearers. The vessel diameters and blood flow velocities (BFVs) were measured. Fractal analysis using Dbox as vessel density and D0 as vessel complexity were used to quantitatively analyze the microvascular network...
August 1, 2018: Investigative Ophthalmology & Visual Science
A L M Tavy, A F J de Bruin, K van der Sloot, E C Boerma, C Ince, P G Noordzij, D Boerma, M van Iterson
BACKGROUND: The effect of thoracic epidural analgesia (TEA) on splanchnic blood flow during abdominal surgery remains unclear. The purpose of this study was to examine whether the hemodynamic effects of TEA resulted in microcirculatory alterations to the intestinal serosa, which was visualized using incident dark-field (IDF) videomicroscopy. METHODS: An observational cohort study was performed. In 18 patients, the microcirculation of the intestinal serosa was visualized with IDF...
August 10, 2018: World Journal of Surgery
Dong-Hyun Lee, Ho Chul Yi, So Hyun Bae, Joon Hee Cho, Sang Wook Choi, Hakyoung Kim
OBJECTIVES: To determine the risk factors for retinal microvascular impairment on optical coherence tomography angiography (OCT-A) in type 2 diabetic patients without clinical diabetic retinopathy (DR). METHODS: This retrospective and cross-sectional study enrolled 74 diabetic patients without clinically evident DR for the study group and 34 healthy subjects for the control group. OCT-A parameters were measured to determine vascular density (VD) and the foveal avascular zone (FAZ) size in the superficial and deep capillary plexuses (SCP/DCP) of the retina...
2018: PloS One
Grace Tsai, Touka Banaee, Felipe F Conti, Rishi P Singh
Optical coherence angiography (OCTA) is a noninvasive technique that has been introduced in recent years to detect ophthalmological pathology. The growing usage of OCTA to detect retinal abnormalities can be attributed to its advantages over the reference-standard fluorescein angiography (FA), although both of these techniques can be used in association. OCTA's advantages include its dye independency, its ability to produce depth-resolved images of retinal and choroidal vessels that yield images of different vascular layers of the retina, and the better delineation of the foveal avascular zone...
July 2018: Journal of Ophthalmic & Vision Research
Khalil Ghasemi Falavarjani, Hamideh Shenazandi, Dariush Naseri, Pasha Anvari, Pegah Kazemi, Farzaneh Aghamohammadi, Feras Alissmail, Sayyed Amirpooya Alemzadeh
Purpose: To report the normal characteristics and correlations of the foveal microvascular networks using optical coherence tomography angiography (OCTA) in a healthy Iranian population. Methods: Enface 3x3 OCTA images were obtained using the RTVue Avanti spectral-domain optical coherence tomography with AngioVue software (Optovue, Fremont, CA, USA). Foveal avascular zone (FAZ) area, central foveal point thickness and inner retinal thickness at the foveal center and the vascular density of the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in the fovea were recorded...
July 2018: Journal of Ophthalmic & Vision Research
Xin Wang, Rongyan Mao, Weiwei Chen
BACKGROUND ox-LDL-induced injury of brain microvascular endothelial cells (BMECs) is strongly associated with cerebral vascular diseases such as cerebral arterial atherosclerosis. ROCK inhibitor was proved to be anti-apoptotic and has been used in treating cerebral vascular diseases. Research on the neuroprotective effects of a novel ROCK inhibitor, FSD-C10, is still limited. The present study investigated the anti-apoptotic effect and underlying molecular mechanism of FSD-C10 in ox-LDL-mediated apoptosis of BMECs...
August 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Lyn M Wise, Gabriella S Stuart, Nicola C Real, Stephen B Fleming, Andrew A Mercer
Objective: Vascular endothelial growth factor (VEGF) family members are critical regulators of tissue repair and depending on their distinct pattern of receptor specificity can also promote inflammation and scarring. This study utilized a receptor-selective VEGF to examine the role of VEGF receptor (VEGFR)-2 in scar tissue (ST) formation. Approach: Cutaneous skin wounds were created in mice using a 4 mm biopsy punch and then treated until closure with purified VEGF-E derived from orf virus stain NZ-2. Tissue samples were harvested to measure gene expression using quantitative PCR and to observe ST formation through histological examination and changes in cell populations by immunofluorescence...
August 1, 2018: Advances in Wound Care
Wei Chen, Jie Chen, Menghao Xu, Zhiyan Zhong, Qing Zhang, Wei Yang, Guangying Huang
Controlled ovarian hyperstimulation (COH) impairs the synchronized development of endometrium and embryo, resulting in the failure of embryo implantation. Here, we investigated what effects electroacupuncture had on embryo implantation in COH rats. Female rats were randomly assigned to 4 groups: normal (group N), model (group M), electroacupuncture (group EA), and electroacupuncture pretreatment (group PEA). Rats in groups M, EA, PEA were injected with pregnant mare serum gonadotropin and human chorionic gonadotropin to establish the COH model...
August 1, 2018: Biology of Reproduction
Maxime Mermod, Massimo Bongiovanni, Tatiana Petrova, Elena Goun, Christian Simon, Genrich Tolstonog, Yan Monnier
Objective The management of occult lymph node metastasis (LNM) in head and neck squamous cell carcinoma has been a matter of controversy for decades. The vascular density within the tumor microenvironment, as an indicator of ongoing angiogenesis, could constitute an attractive predictor of LNM. The use of the panvascular endothelial antibody CD31 as a marker of occult LNM has never been reported. The aim of this study was to assess the predictive value of CD31 microvascular density for the detection of occult LNM in squamous cell carcinoma of the oral cavity and oropharynx...
August 7, 2018: Otolaryngology—Head and Neck Surgery
Alessio Cerquaglia, Barbara Iaccheri, Tito Fiore, Daniela Fruttini, Federica Benedetta Belli, Moncef Khairallah, Marco Lupidi, Carlo Cagini
PURPOSE: To report optical coherence tomography angiography (OCT-A) findings in eyes with ocular sarcoidosis (OS) and to compare these findings with those of fluorescein angiography (FA). METHODS: Observational, cross-sectional, case-control study. Patients presenting with OS involving the posterior segment were evaluated using FA, structural-OCT and OCT-A. OCT-angiograms of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) were qualitatively and quantitatively analyzed...
August 6, 2018: Ocular Immunology and Inflammation
Hassan Mohamed, Hisham Hosny, Pierre Tawadros Md, Mohamed Elayashy Md Desa Fcai, Hossam El-Ashmawi Md
OBJECTIVES: Cardiac surgery is characterized by attenuation of microcirculatory perfusion. Dexmedetomidine has been proved to attenuate the microcirculatory derangements evoked by experimental sepsis. The authors investigated the effects of dexmedetomidine infusion on sublingual microcirculation in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. DESIGN: Prospective, randomized blinded study. SETTINGS: Tertiary university hospital...
June 28, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Zijing Li, Mohammad Alzogool, Jianhui Xiao, Si Zhang, Peng Zeng, Yuqing Lan
AIMS: To evaluate the effect of early screening with OCTA in type 2 diabetes mellitus (T2DM) patients without clinical DR (NDR). METHODS: This was a cross-sectional case-control clinical study. Eighty-four eyes of 84 patients (44 T2DM and 40 control subjects) were included. Images were obtained using AngioVue software 2.0 of the OCTA device. Foveal avascular zone (FAZ) area, FAZ perimeter (PERIM), choriocapillary flow area (CCF), acircularity index (AI), foveal vessel density in a 300-µm-wide region around FAZ (FD), macular-associated vessel density (VD) and optic disc-associated capillary density (CD) were compared between the T2DM and control groups...
July 31, 2018: Acta Diabetologica
Juan D Rojas, Virginie Papadopoulou, Tomasz Czernuszewicz, Rajalekha Rajamahendiran, Anna Chytil, Yun-Chen Chiang, Diana Chong, Victoria Bautch, Kimryn Rathmell, Stephen Aylward, Ryan Gessner, Paul A Dayton
BACKGROUND: Functional and molecular changes often precede gross anatomical changes, so early assessment of a tumor's functional and molecular response to therapy can help reduce a patient's exposure to the side effects of ineffective chemotherapeutics or other treatment strategies. OBJECTIVE: Our intent was to test the hypothesis that an ultrasound microvascular imaging approach might provide indications of response to therapy prior to assessment of tumor size...
July 27, 2018: IEEE Transactions on Bio-medical Engineering
Zühre Uz, Can Ince, Fadi Rassam, Bülent Ergin, Krijn P van Lienden, Thomas M van Gulik
BACKGROUND: The microvascular effects occurring after unilateral preoperative portal vein embolization (PVE) are poorly understood. The aim of this study was to assess the microvascular changes in the embolized and the non-embolized lobes after right PVE. METHODS: Videos of the hepatic microcirculation in patients undergoing right hemihepatectomy following PVE were recorded using a handheld vital microscope (Cytocam) based on incident dark field imaging. Hepatic microcirculation was measured in the embolized and the non-embolized lobes at laparotomy, 3-6 weeks after PVE...
July 26, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Pengfei Li, Yue Zhou, Andrew J Goodwin, James A Cook, Perry V Halushka, Xian K Zhang, Carole L Wilson, Lynn M Schnapp, Basilia Zingarelli, Hongkuan Fan
Pericytes are vascular mural cells and are embedded in the basement membrane of the microvasculature. Recent studies suggest a role for pericytes in LPS-induced microvascular dysfunction and mortality, but the mechanisms of pericyte loss in sepsis are largely unknown. By using cecal ligation and puncture (CLP)-induced murine model of sepsis, we observed that CLP led to lung and renal pericyte loss and reduced lung pericyte density and pericyte/endothelial cell (EC) coverage. Up-regulated Friend leukemia virus integration 1 (Fli-1) mRNA and protein levels were found in lung pericytes from CLP mice in vivo and in LPS-stimulated lung pericytes in vitro...
July 20, 2018: Journal of Infectious Diseases
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