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sumoylation platelets

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https://www.readbyqxmd.com/read/27960034/leukemogenic-kinase-fip1l1-pdgfra-and-a-small-ubiquitin-like-modifier-e3-ligase-pias1-form-a-positive-cross-talk-through-their-enzymatic-activities
#1
Makoto Ibata, Junko Iwasaki, Yoichiro Fujioka, Koji Nakagawa, Stephanie Darmanin, Masahiro Onozawa, Daigo Hashimoto, Yusuke Ohba, Shigetsugu Hatakeyama, Takanori Teshima, Takeshi Kondo
Fusion tyrosine kinases play a crucial role in the development of hematological malignancies. FIP1L1-PDGFRA is a leukemogenic fusion kinase that causes chronic eosinophilic leukemia. As a constitutively active kinase, FIP1L1-PDGFRA stimulates downstream signaling molecules, leading to cellular proliferation and the generation of an anti-apoptotic state. Contribution of the N-terminal FIP1L1 portion is necessary for FIP1L1-PDGFRA to exert its full transforming activity, but the underlying mechanisms have not been fully characterized...
February 2017: Cancer Science
https://www.readbyqxmd.com/read/22075245/urokinase-receptor-associates-with-myocardin-to-control-vascular-smooth-muscle-cells-phenotype-in-vascular-disease
#2
Yulia Kiyan, Anne Limbourg, Roman Kiyan, Sergey Tkachuk, Florian P Limbourg, Aleksandr Ovsianikov, Boris N Chichkov, Hermann Haller, Inna Dumler
OBJECTIVE: The urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) are a potent multifunctional system involved in vascular remodeling. The goal of the study was to unravel the mechanisms of uPA/uPAR-directed vascular smooth muscle cell (VSMC) differentiation. METHODS AND RESULTS: Using cultured human primary VSMCs, we identified a new molecular mechanism controlling phenotypic modulation in vitro and in vivo. We found that the urokinase-type plasminogen activator receptor (uPAR) acts together with the transcriptional coactivator myocardin to regulate the VSMC phenotype...
January 2012: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/16443219/nuclear-localisation-of-endogenous-sumo-1-modified-pdgf-c-in-human-thyroid-tissue-and-cell-lines
#3
Laila J Reigstad, Aurora Martinez, Jan Erik Varhaug, Johan R Lillehaug
We investigated post-translational modification and subcellular localisation of endogenous platelet-derived growth factor-C (PDGF-C) in human thyroid papillary carcinomas (PTC), non-neoplastic thyroid tissues, and a selection of cultured cell lines. PDGF-C expressed nuclear localisation in 95% of all tested cell types in culture and in 10% of the thyrocytes from both PTC and non-neoplastic tissue. The cell lines expressed two forms of full-length PDGF-C, approximately 39 and approximately 55 kDa, in cell membrane and cytosol, while the approximately 55 kDa form dominated in the nucleus where it was partly chromatin-associated...
April 1, 2006: Experimental Cell Research
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