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Poor ovarian reserv

Keiji Sano, Masakazu Yamamoto, Tetsushige Mimura, Itaru Endo, Shoji Nakamori, Masaru Konishi, Masaru Miyazaki, Toshifumi Wakai, Masato Nagino, Keiichi Kubota, Michiaki Unno, Naohiro Sata, Junji Yamamoto, Hiroki Yamaue, Tadahiro Takada
BACKGROUND: Whether non-colorectal non-neuroendocrine liver metastasis (NCNNLM) should be treated surgically remains unclear. METHODS: Data regarding 1639 hepatectomies performed between 2001 and 2010 for 1539 patients with NCNNLM were collected from 124 institutions. Patient characteristics, types of primary tumor, characteristics of liver metastases, and post-hepatectomy outcomes were analyzed. RESULTS: The 5 most frequent primary tumors were gastric carcinoma (540 patients [35%]), gastrointestinal stromal tumor (204 patients [13%]), biliary carcinoma (150 patients [10%]), ovarian cancer (107 patients [7%]), and pancreatic carcinoma (77 patients [5%])...
October 12, 2018: Journal of Hepato-biliary-pancreatic Sciences
Shiran Yakovi, Ido Izhaki, Moshe Ben-Ami, Johnny S Younis
The pathophysiology of the genuine empty follicle syndrome (EFS) is still debated. Ovarian aging has been contested as a cause of this condition. Our aim was to investigate the occurrence of the genuine EFS in cases of a low number of mature follicles in a prospective manner. Ninety-five infertile women were recruited and evaluated following conventional controlled ovarian stimulation (COS) with ≤ six follicles of ≥14 mm diameter on the day of hCG administration. Enrolled women were 37.5 ± 5...
October 10, 2018: Gynecological Endocrinology
Zongtao Liu, Sushan Zhang, Feng Hou, Congxiao Zhang, Jianjun Gao, KeWei Wang
Most common ovarian cancers are epithelial carcinoma in which the etiology for carcinogenesis remains elusive. ANO1/TMEM16A, a member of Ca2+ -activated Cl- channels (CaCCs), has been demonstrated to promote epithelium-originated cancers and whether it plays a role in the pathogenesis of ovarian cancer is unknown. In our study we found that ANO1 proteins were overexpressed in human epithelial ovarian cancer cells and tissue samples. ANO1 protein upregulation was correlated with the clinical FIGO (International Federation of Gynecology and Obstetrics) staging and poor grade in ovarian cancer tissues...
September 22, 2018: International Journal of Cancer. Journal International du Cancer
Yun Huang, Jingyi Li, Fang Zhang, Yifeng Liu, Gufeng Xu, Jing Guo, Runjv Zhang, Yiqing Wu, Juan Liu, Kai Chen, Wei Zhao, Wei Wu, Yanjun Hu, Guangdi Chen, Dan Zhang
PURPOSE: The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction. METHODS: This was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed...
November 2018: Archives of Gynecology and Obstetrics
Manuel Luque-Ramírez, Lucía Jiménez-Mendiguchia, Ana García-Cano, Elena Fernández-Durán, Verónica de Dios Rosa, Lia Nattero-Chávez, Andrés E Ortiz-Flores, Héctor F Escobar-Morreale
BACKGROUND: Testosterone (T) measurement in women are problematic leading to initiatives aiming to improve laboratory standardization of commercial assays. We assessed the impact on the clinical diagnosis of functional hyperandrogenic disorders of a total T immunoassay recently certified by the Centers for Diseases Control and Prevention (CDC). METHODS: We conducted a cross-sectional study including 263 consecutive adult premenopausal women presenting with functional ovarian hyperandrogenism - including polycystic ovary syndrome (PCOS) - and 73 nonhyperandrogenic female volunteers who served to define reference ranges...
September 19, 2018: European Journal of Clinical Investigation
Isabelle Streuli, Julie Benard, Justine Hugon-Rodin, Charles Chapron, Pietro Santulli, Nicola Pluchino
Endometriosis, a hormone-dependant condition affecting around 10% of women in their reproductive years, has frequent consequences on fertility. Indeed, a proportion of women will require assisted reproductive techniques or surgery in order to achieve pregnancy. Recent refining of stimulation protocols and vitrification techniques has created new possibilities in the field of fertility preservation. As a consequence, oocyte vitrification is now discussed not only in oncologic situations, but also in other conditions at risk of altered ovarian reserve and poor fertility outcome...
October 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Emma Gargus, Rebecca Deans, Antoinette Anazodo, Teresa K Woodruff
Cancer treatments can damage the ovaries, causing primary ovarian insufficiency (POI), a condition associated with numerous sequelae that impact long-term quality of life. This article systematically reviews the literature on the prevalence, surveillance, and treatment of POI in survivors of pediatric and adolescent and young adult (AYA) cancers. A systematic review of the literature was conducted in January 2018 through a search of Medline, Embase, Web of Science, and SCOPUS, alongside the screening of relevant reference lists...
September 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Sandro C Esteves, Matheus Roque, Giuliano M Bedoschi, Alessandro Conforti, Peter Humaidan, Carlo Alviggi
Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. Indeed, clinical trials using the current standards to define POR failed to show evidence in favor of a particular treatment modality. Furthermore, critical factors for reproductive success, such as the age-dependent embryo aneuploidy rates and the intrinsic ovarian resistance to gonadotropin stimulation, are not taken into consideration by the current POR criteria...
2018: Frontiers in Endocrinology
Alisha Evans, Sheryl de Lacey, Kelton Tremellen
The aim of this study is to determine Australians' understanding of the decline in fertility with age, social determinants that influence their decision to start a family and attitudes towards ovarian reserve screening as a tool allowing personalised reproductive life planning. An online survey of 383 childless Australian men and women, aged 18-45 years, was conducted. Both sexes overestimated natural and in vitro fertilization (IVF)-assisted fertility potential with increasing age, with the magnitude of overestimation being more pronounced for men and IVF treatment compared with natural conception...
August 30, 2018: Australian Journal of Primary Health
Chi Zhang, Xiyin Wang, Yanett Anaya, Luca Parodi, Lijun Cheng, Matthew L Anderson, Shannon M Hawkins
Women with endometriosis, a benign growth of endometrial tissue outside the uterine cavity, are at increased risk of specific histotypes of epithelial ovarian cancer, such as ovarian endometrioid adenocarcinoma (OEA). Women with OEA who have endometriosis at time of surgical staging demonstrate improved clinical prognosis compared to women with OEA without evidence of endometriosis. However, the molecular contributions of the endometriotic tumor microenvironment to these ovarian cancers remain poorly understood...
August 28, 2018: International Journal of Cancer. Journal International du Cancer
Chengjuan Jin, Zhaojian Liu, Yingwei Li, Hualei Bu, Yu Wang, Ying Xu, Chunping Qiu, Shi Yan, Cunzhong Yuan, Rongrong Li, Nannan Diao, Zhiwei Zhang, Xiangxiang Wang, Lidong Liu, Beihua Kong
Activation of the FOXM1 signaling pathway and the PI3K/AKT/mTOR signaling pathway is associated with poor prognosis in ovarian cancer. In this study, we demonstrated that P15PAF (KIAA0101) was significantly upregulated in high-grade serous ovarian cancer (HGSOC) and that high KIAA0101 expression was associated with poor prognosis. FOXM1 transcriptionally activated KIAA0101 to drive proliferation and metastasis of ovarian cancer cells. KIAA0101 activated the PI3K/AKT/mTOR signaling pathway to inhibit cisplatin-induced apoptosis and autophagy in ovarian cancer cells resulting in cisplatin resistance...
August 21, 2018: International Journal of Cancer. Journal International du Cancer
Yoo-Young Lee, Jeong-Won Lee, Lin Lu, Wei Xu, Alexandra Kollara, Theodore Brown, Eun-Jin Heo, Taymaa May
OBJECTIVE: To determine the optimal timing of adjuvant chemotherapy after primary cytoreductive surgery for advanced epithelial ovarian cancer. METHODS: In a retrospective cohort analysis, data were assessed from women with advanced epithelial ovarian carcinoma treated at Princess Margaret Cancer Centre, Toronto, Canada between 2002 and 2012, and at Samsung Medical Centre, Seoul, Korea, between 2002 and 2015. The treatment interval was defined as the time period between primary cytoreductive surgery and the first cycle of adjuvant chemotherapy...
August 20, 2018: International Journal of Gynaecology and Obstetrics
Juan Enrique Schwarze, Johana Canales, Javier Crosby, Carolina Ortega-Hrepich, Sonia Villa, Ricardo Pommer
The aim of this review is to determine if the use of DHEA increases the likelihood of success in patients with POR. We searched MEDLINE and EMBASE using the terms "DHEA and diminished ovarian reserve", "DHEA and poor response", "DHEA and premature ovarian aging". A fixed effects model was used and Peto's method to get the odds ratio (OR) with 95% confidence intervals (CI 95%). For quantitative variables, Cohen's method was used to present the standardized mean differences (SMD) with their corresponding confidence intervals...
August 20, 2018: JBRA Assisted Reproduction
Xin Lu, Yiqun Li, Bairong Xia, Yunfan Bai, Kun Zhang, Xiaohan Zhang, Hongyu Xie, Fengyu Sun, Yan Hou, Kang Li
Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer-related death due to its non-specific characteristics compared to benign cases and poor prognosis after conventional therapies. Small peptides (SPs) demonstrated to have potential for diagnosis and prognosis were focused on in this study for the discovery of biomarkers that address these issues. Metabolic profiles of fifteen SPs, including nine dipeptides and six tripeptides were acquired from plasma samples of 140 EOC and 158 benign ovarian tumor (BOT) patients...
August 16, 2018: International Journal of Cancer. Journal International du Cancer
Sharon H Anderson, Michael J Glassner, Andrey Melnikov, Gary Friedman, Zulfiya Orynbayeva
PURPOSE: Oocyte competence is critical in success of assisted reproduction. Metabolic signaling between oocyte and cumulus cells within the cumulus-oocyte complex procure oocyte development. This study evaluated the relationship between respirometric activity of cumulus cells and maturity of corresponding oocytes. METHODS: In prospective cohort study, 20 women of age 28-42 undergoing IVF procedure were involved. To evaluate oocyte maturity, the cumulus cells from individual oocytes were assessed flow cytometrically by double labeling of cells with mitochondria specific dyes...
October 2018: Journal of Assisted Reproduction and Genetics
Theresa M Hardy, Mauricio Garnier-Villarreal, Donna O McCarthy, Richard A Anderson, Rebecca M Reynolds
The process of ovarian aging is influenced by a complex and poorly understood interplay of endocrine, metabolic, and environmental factors. The purpose of this study was to explore the feasibility of using latent class analysis to identify subgroups based on cardiometabolic, psychological, and reproductive parameters of health and to describe patterns of anti-Müllerian hormone levels, a biomarker of the ovarian reserve, within these subgroups. Sixty-nine lean (body mass index [BMI] ⩽ 25 kg/m2 ) and severely obese (BMI ⩾ 40 kg/m2 ) postpartum women in Edinburgh, Scotland, were included in this exploratory study...
August 9, 2018: Western Journal of Nursing Research
Willem Verpoest, Catherine Staessen, Patrick M Bossuyt, Veerle Goossens, Gheona Altarescu, Maryse Bonduelle, Martha Devesa, Talia Eldar-Geva, Luca Gianaroli, Georg Griesinger, Georgia Kakourou, Georgia Kokkali, Jana Liebenthron, Maria-Cristina Magli, Monica Parriego, Andreas G Schmutzler, Monica Tobler, Katrin van der Ven, Joep Geraedts, Karen Sermon
STUDY QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) by comprehensive chromosome screening (CCS) of the first and second polar body to select embryos for transfer increase the likelihood of a live birth within 1 year in advanced maternal age women aged 36-40 years planning an ICSI cycle, compared to ICSI without chromosome analysis? SUMMARY ANSWER: PGT-A by CCS in the first and second polar body to select euploid embryos for transfer does not substantially increase the live birth rate in women aged 36-40 years...
September 1, 2018: Human Reproduction
Stacy T Sims, Alison K Heather
NEW FINDINGS: What is the topic of this review? We review methodological considerations for the inclusion of women in sex and menstrual cycle phase comparison studies. What advances does it highlight? Improving the methodological design for studies exploring sex differences, menstrual cycle phase differences and/or endogenous versus exogenous female sex hormones will help to close the gap in our understanding of the effects of endogenous and exogenous hormones on exercise science and sports medicine outcomes...
July 27, 2018: Experimental Physiology
F Fabregues, I González-Foruria, J Peñarrubia, F Carmona
STUDY QUESTION: Is the length of the anogenital distance (AGD) a biomarker of ovarian reserve and response to controlled ovarian stimulation (COS)? SUMMARY ANSWER: Shorter AGD is associated with presence of poor ovarian response. WHAT IS KNOWN ALREADY: Organ development during prenatal life is influenced by the prevailing intrauterine environment, and it has been suggested that nutritional, environmental and toxic factors could affect ovarian reserve set prenatally...
September 1, 2018: Human Reproduction
Shunping Wang, Yi Zhang, Virginia Mensah, Warren J Huber, Yen-Tsung Huang, Ruben Alvero
BACKGROUND: This study sought to clarify the roles of Anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) in predicting live birth, especially in patients with discordant AMH and FSH. A large IVF data set provided by eIVF®, consisting of 13,964 cycles with AMH, FSH, age, BMI, and birth outcomes were evaluated. Patients were categorized into four groups: Good prognosis group (AMH ≥1 ng/ml; FSH < 10 mIU/ml), Poor prognosis group (AMH < 1 ng/ml; FSH ≥10 mIU/ml), Reassuring AMH group (AMH ≥1 ng/ml; FSH ≥10 mIU/ml), and Reassuring FSH group (AMH < 1 ng/ml; FSH < 10 mIU/ml)...
July 16, 2018: Journal of Ovarian Research
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