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Poor ovarian reserv

Sheena L P Regan, Phil G Knight, John L Yovich, Frank Arfuso, Arun Dharmarajan
OBJECTIVE: To study the effect of aging and granulosa cell growth hormone receptor (GHR) expression, and the effect of growth hormone (GH) co-treatment during IVF on receptor expression. DESIGN: Laboratory study. SETTING: University. PATIENT(S): A total of 445 follicles were collected from 62 women undergoing standard infertility treatment. INTERVENTION(S): Preovulatory ovarian follicle biopsies of granulosa cells and follicular fluid...
December 2018: Fertility and Sterility
Haining Luo, Ying Han, Jiao Liu, Yunshan Zhang
This study aimed to determine the microRNA (miRNA) profiles in granulosa cells (GCs) from the follicular fluid (FF) of patients with varying levels of ovarian reserve function. We included 45 women undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment. After collecting GCs from each patient, total RNA was extracted from 12 samples. Using Illumina/deep-sequencing technology, we analyzed the small RNAs in each group. Using the R package, we identified the differentially expressed (DE) miRNAs among patients with varying levels of ovarian reserve function...
November 16, 2018: Gene
Ahmed M Maged, Radwa M Fahmy, Hamsa Rashwan, Maryam Mahmood, Sarah M Hassan, Hala Nabil, Ayman Hany, Rehab Lotfy, Yossra S Lasheen, Sherif Dahab, Mohamed Darwish
OBJECTIVE: To assess the effects of body mass index (BMI) on the outcome of IVF cycles among poor responders. METHODS: A prospective cohort study in Egypt enrolled 185 poor responders who underwent intracytoplasmic sperm injection via an antagonist protocol between 2012 and 2017. Participants were classified into three groups by BMI (calculated as weight in kilograms divided by the square of height in meters): 18.5-24.9 (normal, n=48); 25-29.9 (overweight, n=54); 30 or higher (obese, n=83)...
November 8, 2018: International Journal of Gynaecology and Obstetrics
Tuan Zea Tan, Valerie Heong, Jieru Ye, Diana Lim, Jeffrey Low, Mahesh Choolani, Clare Scott, David Shao Peng Tan, Ruby Yun-Ju Huang
The evaluation of intra-tumour heterogeneity (ITH) from a transcriptomic point of view is limited. Single-cell cancer studies reveal significant genomic and transcriptomic ITH within a tumour and it is no longer adequate to employ single-subtype assignment as this does not acknowledge the ITH that exists. Molecular assessment of subtype heterogeneity (MASH) was developed to comprehensively report on the composition of all transcriptomic subtypes within a tumour lesion. Using MASH on 3,431 ovarian cancer samples, correlation and association analyses with survival, metastasis, and clinical outcomes were performed to assess the impact of subtype composition as a surrogate for ITH...
October 30, 2018: Journal of Pathology
Omar Sefrioui, Aicha Madkour, Smahane Aboulmaouahib, Ismail Kaarouch, Noureddine Louanjli
Circulating anti-müllerian hormone (AMH) and antral follicle count (AFC) are the best predictors of IVF outcomes. However, in extreme low AMH range especially for young patients, AMH prediction power loose its specificity to give real idea of pregnancy chance with IVF treatments and good prognosis of an extremely reduced ovarian reserve and expected poor response. Indeed, this retrospective study was conducted to evaluate IVF outcomes in patients following IVF-ICSI program with extremely low AMH levels (≤0...
October 16, 2018: Gynecological Endocrinology
Keiji Sano, Masakazu Yamamoto, Tetsushige Mimura, Itaru Endo, Shoji Nakamori, Masaru Konishi, Masaru Miyazaki, Toshifumi Wakai, Masato Nagino, Keiichi Kubota, Michiaki Unno, Naohiro Sata, Junji Yamamoto, Hiroki Yamaue, Tadahiro Takada
BACKGROUND: Whether non-colorectal non-neuroendocrine liver metastasis (NCNNLM) should be treated surgically remains unclear. METHODS: Data regarding 1,639 hepatectomies performed between 2001 and 2010 for 1,539 patients with NCNNLM were collected from 124 institutions. Patient characteristics, types of primary tumor, characteristics of liver metastases, and post-hepatectomy outcomes were analyzed. RESULTS: The five most frequent primary tumors were gastric carcinoma (540 patients [35%]), gastrointestinal stromal tumor (204 patients [13%]), biliary carcinoma (150 patients [10%]), ovarian cancer (107 patients [7%]), and pancreatic carcinoma (77 patients [5%])...
October 12, 2018: Journal of Hepato-biliary-pancreatic Sciences
Shiran Yakovi, Ido Izhaki, Moshe Ben-Ami, Johnny S Younis
The pathophysiology of the genuine empty follicle syndrome (EFS) is still debated. Ovarian aging has been contested as a cause of this condition. Our aim was to investigate the occurrence of the genuine EFS in cases of a low number of mature follicles in a prospective manner. Ninety-five infertile women were recruited and evaluated following conventional controlled ovarian stimulation (COS) with ≤ six follicles of ≥14 mm diameter on the day of hCG administration. Enrolled women were 37.5 ± 5...
October 10, 2018: Gynecological Endocrinology
Zongtao Liu, Sushan Zhang, Feng Hou, Congxiao Zhang, Jianjun Gao, KeWei Wang
Most common ovarian cancers are epithelial carcinoma in which the etiology for carcinogenesis remains elusive. ANO1/TMEM16A, a member of Ca2+ -activated Cl- channels (CaCCs), has been demonstrated to promote epithelium-originated cancers and whether it plays a role in the pathogenesis of ovarian cancer is unknown. In our study we found that ANO1 proteins were overexpressed in human epithelial ovarian cancer cells and tissue samples. ANO1 protein upregulation was correlated with the clinical FIGO (International Federation of Gynecology and Obstetrics) staging and poor grade in ovarian cancer tissues...
September 22, 2018: International Journal of Cancer. Journal International du Cancer
Yun Huang, Jingyi Li, Fang Zhang, Yifeng Liu, Gufeng Xu, Jing Guo, Runjv Zhang, Yiqing Wu, Juan Liu, Kai Chen, Wei Zhao, Wei Wu, Yanjun Hu, Guangdi Chen, Dan Zhang
PURPOSE: The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction. METHODS: This was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed...
November 2018: Archives of Gynecology and Obstetrics
Manuel Luque-Ramírez, Lucía Jiménez-Mendiguchia, Ana García-Cano, Elena Fernández-Durán, Verónica de Dios Rosa, Lia Nattero-Chávez, Andrés E Ortiz-Flores, Héctor F Escobar-Morreale
BACKGROUND: Testosterone (T) measurement in women is problematic leading to initiatives aiming to improve laboratory standardization of commercial assays. We assessed the impact on the clinical diagnosis of functional hyperandrogenic disorders of a total T immunoassay recently certified by the Centers for Diseases Control and Prevention (CDC). METHODS: We conducted a cross-sectional study including 263 consecutive adult premenopausal women presenting with functional ovarian hyperandrogenism-including polycystic ovary syndrome (PCOS)-and 73 nonhyperandrogenic female volunteers who served to define reference ranges...
December 2018: European Journal of Clinical Investigation
Isabelle Streuli, Julie Benard, Justine Hugon-Rodin, Charles Chapron, Pietro Santulli, Nicola Pluchino
Endometriosis, a hormone-dependant condition affecting around 10% of women in their reproductive years, has frequent consequences on fertility. Indeed, a proportion of women will require assisted reproductive techniques or surgery in order to achieve pregnancy. Recent refining of stimulation protocols and vitrification techniques has created new possibilities in the field of fertility preservation. As a consequence, oocyte vitrification is now discussed not only in oncologic situations, but also in other conditions at risk of altered ovarian reserve and poor fertility outcome...
October 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Emma Gargus, Rebecca Deans, Antoinette Anazodo, Teresa K Woodruff
Cancer treatments can damage the ovaries, causing primary ovarian insufficiency (POI), a condition associated with numerous sequelae that impact long-term quality of life. This article systematically reviews the literature on the prevalence, surveillance, and treatment of POI in survivors of pediatric and adolescent and young adult (AYA) cancers. A systematic review of the literature was conducted in January 2018 through a search of Medline, Embase, Web of Science, and SCOPUS, alongside the screening of relevant reference lists...
September 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Sandro C Esteves, Matheus Roque, Giuliano M Bedoschi, Alessandro Conforti, Peter Humaidan, Carlo Alviggi
Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous gonadotropin stimulation present a challenge for reproductive specialists. The primary reasons relate to the still limited knowledge about the POR pathophysiology and the lack of practical solutions for the management of these conditions. Indeed, clinical trials using the current standards to define POR failed to show evidence in favor of a particular treatment modality. Furthermore, critical factors for reproductive success, such as the age-dependent embryo aneuploidy rates and the intrinsic ovarian resistance to gonadotropin stimulation, are not taken into consideration by the current POR criteria...
2018: Frontiers in Endocrinology
Alisha Evans, Sheryl de Lacey, Kelton Tremellen
The aim of this study is to determine Australians' understanding of the decline in fertility with age, social determinants that influence their decision to start a family and attitudes towards ovarian reserve screening as a tool allowing personalised reproductive life planning. An online survey of 383 childless Australian men and women, aged 18-45 years, was conducted. Both sexes overestimated natural and in vitro fertilization (IVF)-assisted fertility potential with increasing age, with the magnitude of overestimation being more pronounced for men and IVF treatment compared with natural conception...
August 30, 2018: Australian Journal of Primary Health
Chi Zhang, Xiyin Wang, Yanett Anaya, Luca Parodi, Lijun Cheng, Matthew L Anderson, Shannon M Hawkins
Women with endometriosis, a benign growth of endometrial tissue outside the uterine cavity, are at increased risk of specific histotypes of epithelial ovarian cancer, such as ovarian endometrioid adenocarcinoma (OEA). Women with OEA who have endometriosis at time of surgical staging demonstrate improved clinical prognosis compared to women with OEA without evidence of endometriosis. However, the molecular contributions of the endometriotic tumor microenvironment to these ovarian cancers remain poorly understood...
November 15, 2018: International Journal of Cancer. Journal International du Cancer
Chengjuan Jin, Zhaojian Liu, Yingwei Li, Hualei Bu, Yu Wang, Ying Xu, Chunping Qiu, Shi Yan, Cunzhong Yuan, Rongrong Li, Nannan Diao, Zhiwei Zhang, Xiangxiang Wang, Lidong Liu, Beihua Kong
Activation of the FOXM1 signaling pathway and the PI3K/AKT/mTOR signaling pathway is associated with poor prognosis in ovarian cancer. In this study, we demonstrated that P15PAF (KIAA0101) was significantly upregulated in high-grade serous ovarian cancer (HGSOC) and that high KIAA0101 expression was associated with poor prognosis. FOXM1 transcriptionally activated KIAA0101 to drive proliferation and metastasis of ovarian cancer cells. KIAA0101 activated the PI3K/AKT/mTOR signaling pathway to inhibit cisplatin-induced apoptosis and autophagy in ovarian cancer cells resulting in cisplatin resistance...
August 21, 2018: International Journal of Cancer. Journal International du Cancer
Yoo-Young Lee, Jeong-Won Lee, Lin Lu, Wei Xu, Alexandra Kollara, Theodore Brown, Eun-Jin Heo, Taymaa May
OBJECTIVE: To determine the optimal timing of adjuvant chemotherapy after primary cytoreductive surgery for advanced epithelial ovarian cancer. METHODS: In a retrospective cohort analysis, data were assessed from women with advanced epithelial ovarian carcinoma treated at Princess Margaret Cancer Centre, Toronto, Canada between 2002 and 2012, and at Samsung Medical Centre, Seoul, Korea, between 2002 and 2015. The treatment interval was defined as the time period between primary cytoreductive surgery and the first cycle of adjuvant chemotherapy...
August 20, 2018: International Journal of Gynaecology and Obstetrics
Juan Enrique Schwarze, Johana Canales, Javier Crosby, Carolina Ortega-Hrepich, Sonia Villa, Ricardo Pommer
The aim of this review is to determine if the use of DHEA increases the likelihood of success in patients with POR. We searched MEDLINE and EMBASE using the terms "DHEA and diminished ovarian reserve", "DHEA and poor response", "DHEA and premature ovarian aging". A fixed effects model was used and Peto's method to get the odds ratio (OR) with 95% confidence intervals (CI 95%). For quantitative variables, Cohen's method was used to present the standardized mean differences (SMD) with their corresponding confidence intervals...
November 1, 2018: JBRA Assisted Reproduction
Xin Lu, Yiqun Li, Bairong Xia, Yunfan Bai, Kun Zhang, Xiaohan Zhang, Hongyu Xie, Fengyu Sun, Yan Hou, Kang Li
Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer-related death due to its non-specific characteristics compared to benign cases and poor prognosis after conventional therapies. Small peptides (SPs) demonstrated to have potential for diagnosis and prognosis were focused on in this study for the discovery of biomarkers that address these issues. Metabolic profiles of fifteen SPs, including nine dipeptides and six tripeptides were acquired from plasma samples of 140 EOC and 158 benign ovarian tumor (BOT) patients...
August 16, 2018: International Journal of Cancer. Journal International du Cancer
Sharon H Anderson, Michael J Glassner, Andrey Melnikov, Gary Friedman, Zulfiya Orynbayeva
PURPOSE: Oocyte competence is critical in success of assisted reproduction. Metabolic signaling between oocyte and cumulus cells within the cumulus-oocyte complex procure oocyte development. This study evaluated the relationship between respirometric activity of cumulus cells and maturity of corresponding oocytes. METHODS: In prospective cohort study, 20 women of age 28-42 undergoing IVF procedure were involved. To evaluate oocyte maturity, the cumulus cells from individual oocytes were assessed flow cytometrically by double labeling of cells with mitochondria specific dyes...
October 2018: Journal of Assisted Reproduction and Genetics
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