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Vogt-Koyanagi-Harada syndrome

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https://www.readbyqxmd.com/read/30024478/swept-source-optical-coherence-tomography-and-optical-coherence-tomography-angiography-findings-in-waardenburg-syndrome
#1
Andrew Matthew Hsiao, Netan Choudhry
PURPOSE: Waardenburg syndrome (WS) is a rare condition characterized by six main features. It has been previously observed that WS is also associated with hypopigmentation of the choroid through multimodal imaging. To our knowledge, this is the first report of using swept-source optical coherence tomography angiography (OCTA) on a patient with known WS. METHODS: Report of a single case. The swept-source OCT images were captured using Topcon DRI OCT Triton (Topcon, Inc, Tokyo, Japan), whereas swept-source OCTA images were captured by Optovue AngioVue (Optovue, Inc, Fremont, CA) using DualTrack Motion Correction Technology...
July 16, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29998211/long-term-treatment-with-infliximab-in-pediatric-vogt-koyanagi-harada-disease
#2
Gustavo A Budmann, Ludmila García Franco, Alejandra Pringe
Purpose: To report a case of pediatric Vogt-Koyanagi-Harada (VKH) successfully treated with infliximab and methotrexate for ten years. Observations: A 9-year-old Hispanic girl with VKH disease, was successfully treated with oral methotrexate 15 mg/week and oral prednisone 40 mg/day (1mg/kg/day). But when oral prednisone was tapered to 10 mg/day over a 3-month period, inflammation recurred. Patient was considered as corticosteroid-dependent thus infliximab 7mg/kg/pulse was started on days 0, 15, 60 and every 60 days thereafter...
September 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29786006/rebound-inflammation-after-an-intravitreal-injection-in-vogt-koyanagi-harada-syndrome
#3
Richa Ranjan, Manisha Agarwal
A 43-year-old male with chronic Vogt-Koyanagi-Harada syndrome (VKH) presented with subfoveal choroidal neovascular membrane (CNVM) in the right eye with no evidence of active inflammation. He underwent intravitreal bevacizumab and dexamethasone injections. Postinjection he developed fresh keratic precipitates and exudative retinal detachment (RD). He received two more bevacizumab injections with oral corticosteroids and immunosuppressants causing resolution of exudative RD with scarred CNVM. We report this case to highlight that intravitreal injection may act as a trigger for rebound inflammation in VKH patients and may require anti-inflammatory drugs to be started even in the absence of an active inflammation...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29730378/vogt-koyanagi-harada-syndrome-induced-by-pembrolizumab-in-a-patient-with-non-small-cell-lung-cancer
#4
Tomoki Tamura, Etsuko Akimoto, Chiaki Matsumoto, Syunta Mori, Tatuya Nishi, Kennichiro Kudo, Syouichi Kuyama
No abstract text is available yet for this article.
May 3, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29719650/intraocular-lens-calcification-clinico-pathological-report-of-two-cases-and-literature-review
#5
Mansour Rahimi, Ali Azimi, Masoud Hosseinzadeh
Purpose: We report the clinicopathological features and surgical outcomes of two cases of intraocular lens (IOL) calcification along with a review of the current literature. Case Report: The first patient was a 53-year-old woman with diabetes mellitus (type 2) who underwent phacoemulsification with posterior chamber IOL insertion (PCIOL), and pars plana vitrectomy. Significant clouding of the IOL was first noted after 1.5 years, and the IOL was replaced with an Artisan lens...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29681837/unusual-case-of-vogt-koyanagi-harada-disease-associated-with-sapho-syndrome-a-case-report
#6
Miyuki Hasegawa, Akira Fukutomi, Akiko Jinno, Kyoko Fujita, Motohiro Kamei
A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. The symptoms persisted in spite of treatment. She was then referred to our hospital. At her initial visit, the visual acuities were 0.6 in both eyes. A slit-lamp examination revealed bilateral shallow anterior chamber, and intraocular pressures of 18 mm Hg in the right eye and 16 mm Hg in the left eye...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29615180/a-case-of-vogt-koyanagi-harada-syndrome-mimicking-optic-neuritis
#7
Muhammad Mateen Amir, Atif Masood, Zarmina Khan
Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. On examination, there was 6/24 vision, sluggish pupillary reaction and disc hyperemia in both eyes. She was treated as a case of optic neuritis. Few days later, she developed bilateral panuveitis, shallow exudative detachments and alopecia...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29600191/late-onset-acute-vogt-koyanagi-harada-syndrome-challenges-on-the-way
#8
Sandra Rodrigues-Barros, Jacqueline Martins Sousa, Bruno Carvalho, Gabriel Andrade, Heloísa Nascimento
No abstract text is available yet for this article.
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29489658/positron-emission-tomography-computed-tomography-scan-of-vogt-koyanagi-harada-syndrome-with-associated-autoimmune-thyroid-disease-a-case-report-and-literature-review
#9
REVIEW
Ke-Hao Huang, Ming-Cheng Tai, Lung-Chi Lee, Tzu-Heng Weng, Yi-Hao Chen, Li-Fan Lin, Jiann-Torng Chen, Da-Wen Lu, Ching-Long Chen
RATIONALE: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29285231/associations-between-tnfsf4-tnfsf8-and-tnfsf15-and-beh%C3%A3-et-s-disease-but-not-vkh-syndrome-in-han-chinese
#10
Yan Jiang, Ling Cheng, Xin Li, Wenke Zhou, Li Zhang
The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese. The study sample included 796 patients with BD, 792 patients with VKH syndrome, and 1604 healthy controls. The genotyping of 35 SNPs was performed by MassARRAY platform (Sequenom), iPLEX Gold Assay, PCR-restriction fragment length polymorphism assay and TaqMan SNP assay...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29248206/current-and-newly-emerging-autoimmune-diseases
#11
REVIEW
Laurel J Gershwin
There are many autoimmune diseases that are recognized in domestic animals. The descriptions of diseases provide examples of the magnitude of immune targets and the variable nature of autoimmune diseases. Other autoimmune diseases that are recognized in dogs, cats, and horses include immune-mediated thrombocytopenia, VKH (Vogt-Koyanagi-Harada) ocular disease (dogs), and Evans syndrome (which includes both immune-mediated anemia and immune-mediated thrombocytopenia).
March 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29121363/treatment-of-ipilimumab-induced-vogt-koyanagi-harada-syndrome-with-oral-dexamethasone
#12
Matthew T Witmer
The author presents a retrospective case report of a 54-year-old male with ipilimumab (Yervoy; Bristol-Myers Squibb, New York City, NY)-induced Vogt-Koyanagi-Harada Disease (VKH), which consisted of uveitis, optic neuritis, and choroiditis that was successfully treated with oral dexamethasone. The patient demonstrated resolution of uveitis, optic neuritis, and choroiditis 1 month following initiation of oral dexamethasone. Ipilimumab is a recently approved therapy for malignant melanoma. Reports have identified that VKH disease is a potential side effect of the medication...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28984712/acute-angle-closure-secondary-to-tubercular-choroidal-granuloma
#13
Sushmita Kaushik, Ramandeep Singh, Atul Arora, Gunjan Joshi, Kusum Sharma, Basavraj Tigari
Acute angle closure is usually thought to be secondary to pupillary block, which is relieved by laser iridotomy. Anterior rotation of the ciliary body at the scleral spur following development of an inflammatory ciliochoroidal detachment may result in a presentation of acute angle closure. It is imperative to recognize this condition correctly, because the management is with cycloplegics and anti-inflammatory drugs, which is diametrically opposite to the treatment of primary angle closure. More importantly, it has been reported as a consequence of serious systemic disease such as HIV infection and Vogt Koyanagi Harada (VKH) syndrome...
December 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28983414/anti-tnf%C3%AE-therapy-and-switching-in-severe-uveitis-related-to-vogt-koyanagi-harada-syndrome
#14
Bryan Josue Flores-Robles, Juan Blanco-Madrigal, Abel Alejandro Sanabria-Sanchinel, Dixie Huntley Pascual, Rosario Demetrio-Pablo, Ricardo Blanco
The study aimed to describe the effectiveness of switching the anti-TNFα agent when an acceptable clinical response has not been obtained with the first anti-TNFα agent in patients with uveitis in VKH syndrome. Patients diagnosed with VKH syndrome being evaluated from the uveitis unit of a single tertiary hospital from January 1, 2000, to October 30, 2015. Patients who presented uveitis with an inadequate response to a first anti-TNFα and required switching to a second anti-TNFα were selected. Complete clinical response was assumed in patients whose visual acuity was normal and those who showed absence of inflammatory findings (inflammatory cells in the anterior chamber and vitritis) or absence of macular thickening in upon OCT...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28979622/-vitiligo-revealing-vogt-koyanagi-harada-disease
#15
Mohamed El Amraoui, Youssef Zemmez, Ahmed Bouhamidi, Rachid Frikh, Naoufal Hjira, Mohammed Boui
Vitiligo is a chronic auto-immune skin disease, often associated or discovers other autoimmune pathologies. His association with Ophthalmological type pan uveitis and/or neurological type of meningitis and/or inner ear type of hearing loss determines the disease or Vogt -Koyanagi-Harada syndrome (VKH). We related the case of a young woman who consulted for recurrent uveitis for a year, and it was only with the onset of vitiligo lesions that VKH disease diagnosis was discussed and confirmed.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28972425/lord-nelson-s-1758-1805-left-eye
#16
William Pryse-Phillips
Following the loss of his right eye at Calvi in 1794, Lord Nelson suffered increasing left-sided visual loss, here considered most likely to have been due to the ocular inflammatory condition 'sympathetic ophthalmia'. It is also argued that his succeeding episodes of violent headaches with nausea and prostration, and possible depigmentation of hair, reflected the development of an uveomeningoencephalitic syndrome akin to that of Vogt-Koyanagi-Harada disease, which is best regarded as the same condition with a different aetiology...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/28910557/vogt-koyanagi-harada-syndrome-in-a-group-of-patients-in-two-ophthalmology-referral-centers-in-bogot%C3%A3-colombia
#17
Carol L Guayacán, Brahyan Galindo-Mendez, Alejandra de-la-Torre
PURPOSE: To describe the clinical presentation of Vogt-Koyanagi-Harada (VKH) syndrome in a group of patients in Colombia. METHODS: Retrospective review of 2638 medical records of patients with uveitis in two centers during 17 years. RESULTS: A total of 25 patients with uveitis were diagnosed with VKH syndrome (0.95%), 23 patients were included in the data analysis (0.87%), 78.3% females, and mean age of diagnosis was 37 years (SD ± 29)...
September 14, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28905833/unusual-case-of-vitiligo-reversal-in-vogt-koyanagi-harada-syndrome
#18
Praveen Subudhi, Zahiruddin Khan, B Nageswar Rao Subudhi, Silla Sitaram
No abstract text is available yet for this article.
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28863408/polarization-sensitive-optical-coherence-tomographic-documentation-of-choroidal-melanin-loss-in-chronic-vogt-koyanagi-harada-disease
#19
Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Rintaro Tsukahara, Yoshihiko Usui, Narsing A Rao, Yasushi Ikuno, Sato Uematsu, Tetsuya Agawa, Takuya Iwasaki, Hiroshi Goto
Purpose: Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder that affects organs with melanocytes. The sunset glow fundus (SGF) in VKH disease was evaluated with polarization-sensitive optical coherence tomography (PS-OCT). Methods: The study involved 28 eyes from 14 patients with chronic VKH disease, 21 eyes from 21 age-matched controls, and 22 eyes from 22 high-myopic patients with a tessellated fundus. VKH eyes were grouped into sunset or non-sunset groups on the basis of color fundus images...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28846771/association-of-a-pdcd1-polymorphism-with-sympathetic-ophthalmia-in-han-chinese
#20
Jing Deng, Jiayue Hu, Handan Tan, Guannan Su, Qingfeng Cao, Xinyue Huang, Aize Kijlstra, Peizeng Yang
Purpose: Several studies have shown that sympathetic ophthalmia (SO) and Vogt-Koyanagi-Harada (VKH) disease possess many similarities concerning their clinical manifestations. The aim of this study was to investigate whether single nucleotide polymorphisms that have been shown to be associated with VKH disease in earlier studies may also be associated with SO. Methods: There were 114 SO patients and 1230 healthy controls included in a case-control study, whereby 24 VKH-related single nucleotide polymorphisms (SNPs) were tested...
August 1, 2017: Investigative Ophthalmology & Visual Science
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