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Line Småstuen Haug, Amrit Kaur Sakhi, Enrique Cequier, Maribel Casas, Léa Maitre, Xavier Basagana, Sandra Andrusaityte, Georgia Chalkiadaki, Leda Chatzi, Muireann Coen, Jeroen de Bont, Audrius Dedele, Joane Ferrand, Regina Grazuleviciene, Juan Ramon Gonzalez, Kristine Bjerve Gutzkow, Hector Keun, Rosie McEachan, Helle Margrete Meltzer, Inga Petraviciene, Oliver Robinson, Pierre-Jean Saulnier, Rémy Slama, Jordi Sunyer, José Urquiza, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen
BACKGROUND: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. OBJECTIVES: To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. METHODS: We relied on the Early-Life Exposome project, HELIX, a collaborative project across six established population-based birth cohort studies in Europe...
October 13, 2018: Environment International
Vishva M Sharma, Esben Thyssen Vestergaard, Niels Jessen, Peter Kolind-Thomsen, Birgitte Nellemann, Thomas S Nielsen, Mikkel Holm Vendelbo, Niels Møller, Rita Sharma, Kevin Y Lee, John J Kopchick, Jens Otto Lunde Jørgensen, Vishwajeet Puri
The lipolytic effects of GH have been known for half a century and play an important physiological role for substrate metabolism during fasting. In addition, sustained GH-induced lipolysis is causally linked to insulin resistance. However, the underlying molecular mechanisms remain elusive. In the present study, we obtained experimental data in human subjects and used human adipose-derived stromal vascular cells (hADSCs) as a model system to elucidate GH-triggered molecular signaling that stimulates adipose tissue lipolysis and insulin resistance in human adipocytes...
October 16, 2018: American Journal of Physiology. Endocrinology and Metabolism
Lise Haaber Thomsen, Ulrik Schiøler Kesmodel, Claus Yding Andersen, Peter Humaidan
No abstract text is available yet for this article.
October 15, 2018: Human Reproduction
Hans Linde Nielsen, Irene Harder Tarpgaard, David Fuglsang-Damgaard, Philip Kjettinge Thomsen, Sylvain Brisse, Michael Dalager-Pedersen
Introduction: Elizabethkingia anophelis is a Gram-negative, aerobic, non-motile rod belonging to the family Flavobacteriaceae . Over the last 5 years, it has emerged as an opportunistic human pathogen involved in neonatal meningitis and sepsis, as well as nosocomial outbreaks. It has been isolated from the midgut of the Anopheles gambiae mosquito, but there is no evidence for a role of the mosquito in human infections, and very little is known regarding the routes of transmission to humans...
August 2018: JMM Case Reports
Sara Roos, Kalliopi Sofou, Carola Hedberg-Oldfors, Gittan Kollberg, Ulrika Lindgren, Christer Thomsen, Mar Tulinius, Anders Oldfors
Mitochondrial myopathies are a heterogeneous group of disorders associated with a wide range of clinical phenotypes. We present a 16-year-old girl with a history of exercise intolerance since childhood. Acylcarnitine species suggestive of multiple acyl-CoA dehydrogenase deficiency were found in serum, however genetic analysis did not reveal variants in genes associated with this disorder. Biochemical analyses of skeletal muscle mitochondria revealed an isolated and extremely low activity of cytochrome c oxidase (COX)...
October 12, 2018: European Journal of Human Genetics: EJHG
Christian Niels Meyer, Karin Armbruster, Michael Kemp, Trine Rolighed Thomsen, Ram Benny Dessau
BACKGROUND: We explored the hypothesized importance of early knowledge of microbiological etiology in patients with pleural infection, including comorbidity and treatment factors in the outcome analyses. METHODS: Data from the medical records of a large cohort of 437 consecutive patients in 9 hospitals in East-Denmark were included retrospectively. RESULTS: Microbiology, co-morbidity, therapy and outcome are described in detail. Patient groups with microbiology negative and known bacterial etiology had a similar 30-day and 90-day mortality...
October 12, 2018: BMC Pulmonary Medicine
Lotte Rasmussen, Niels Bilenberg, Martin Thomsen Ernst, Sidsel Abitz Boysen, Anton Pottegård
Children with autism spectrum disorder (ASD) have a considerable use of psychotropics. Leveraging nationwide registry data, we aimed to describe the use of psychotropics among children and adolescents with ASD in Denmark. Use of melatonin and attention-deficit/hyperactivity disorder (ADHD) medication increased from 2010 to 2017, while there were limited changes in use of antidepressants and antipsychotics. Thirty percent of the identified children used psychotropics in 2017 most commonly ADHD medication (17%) and melatonin (13%)...
October 10, 2018: Journal of Clinical Medicine
Cornelius Engelmann, Karen Louise Thomsen, Nekisa Zakeri, Mohammed Sheikh, Banwari Agarwal, Rajiv Jalan, Rajeshwar P Mookerjee
BACKGROUND: Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis and is defined by organ failure and high rates of short-term mortality. Patients with ACLF are managed with multiorgan support in the intensive care unit (ICU). Currently, it is unclear when this supportive care becomes futile, particularly in patients who are not candidates for liver transplant. The aim of this study was to determine whether the currently available prognostic scores can identify patients with ACLF in whom prolonged ICU care is likely to be futile despite maximal treatment efforts...
October 10, 2018: Critical Care: the Official Journal of the Critical Care Forum
Louise Norman Jespersen, Susan Ishøy Michelsen, Bjørn Evald Holstein, Tine Tjørnhøj-Thomsen, Pernille Due
BACKGROUND: Measurement of quality of life demands thoroughly developed and validated instruments. The development steps from theory to concepts and from empirical data to items are sparsely described in the literature of questionnaire development. Furthermore, there seems to be a need for an instrument measuring quality of life and participation in a population with diverse disabilities. The aim of this paper was to present and discuss the initial steps in the development of the Electronic Quality of Life questionnaire (EQOL)...
October 11, 2018: Health and Quality of Life Outcomes
Maribel Casas, Xavier Basagaña, Amrit K Sakhi, Line S Haug, Claire Philippat, Berit Granum, Cyntia B Manzano-Salgado, Céline Brochot, Florence Zeman, Jeroen de Bont, Sandra Andrusaityte, Leda Chatzi, David Donaire-Gonzalez, Lise Giorgis-Allemand, Juan R Gonzalez, Esther Gracia-Lavedan, Regina Grazuleviciene, Mariza Kampouri, Sarah Lyon-Caen, Pau Pañella, Inga Petraviciene, Oliver Robinson, Jose Urquiza, Marina Vafeiadi, Céline Vernet, Dagmar Waiblinger, John Wright, Cathrine Thomsen, Rémy Slama, Martine Vrijheid
BACKGROUND: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. OBJECTIVES: We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide metabolites, and cotinine, between weeks from different pregnancy trimesters in pregnant women, and between days and between seasons in children...
October 6, 2018: Environment International
Emilie Amaro, Tanya K Marvi, Samuel L Posey, Michael A Benvenuti, Thomas J An, Kevin M Dale, Steven A Lovejoy, Jeffrey E Martus, Megan E Johnson, Gregory A Mencio, Stephanie N Moore-Lotridge, Isaac P Thomsen, Jonathan G Schoenecker
BACKGROUND: The rate of venous thromboembolism in children with musculoskeletal infections (MSKIs) is markedly elevated compared with hospitalized children in general. Predictive biomarkers to identify high-risk patients are needed to prevent the significant morbidity and rare mortality associated with thrombotic complications. We hypothesize that overactivation of the acute phase response is associated with the development of pathologic thrombi and we aim to determine whether elevations in C-reactive protein (CRP) are associated with increased rates of thrombosis in pediatric patients with MSKI...
October 8, 2018: Journal of Pediatric Orthopedics
Rami Mossad Ibrahim, Gudjon Leifur Gunnarsson, Javed Akram, Jens Ahm Sørensen, Jørn Bo Thomsen
Background: Flaps are increasingly popularized in reconstructive surgery and there is need to test and increase their reliability. Color Doppler ultrasound has been stated to be valuable in flap planning. The aim of this study was to conduct a systematic review and meta-analysis of the literature of Color Doppler ultrasound targeted pedicled perforator flaps and provide information on outcomes and complication rates. Method: A systematic review and meta-analysis were conducted for articles published until April 2017 in PubMed and Embase...
2018: European Journal of Plastic Surgery
Davíö R M A Højgaard, Katja A Hybel, Erik Lykke Mortensen, Tord Ivarsson, Judith Becker Nissen, Bernhard Weidle, Karin Melin, Nor Christian Torp, Kitty Dahl, Robert Valderhaug, Gudmundur Skarphedinsson, Eric A Storch, Per Hove Thomsen
Our aims were to examine: (1) classes of comorbid disorders in a sample of children and adolescents with Obsessive-Compulsive Disorder (OCD), (2) how these classes relate to obsessive-compulsive symptom dimensions, and (3) the extent to which obsessive-compulsive symptom dimensions predict Cognitive-Behavioral Therapy (CBT) outcome. Participants (N = 269) were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS)...
September 22, 2018: Psychiatry Research
Astrid-Helene Ravn Jørgensen, Simon Francis Thomsen, Hans Christian Ring
We read with great interest the article by Theut Riis et al.1 , in which HS patients with high body mass index (BMI) is compared with HS patients with low BMI to investigate differences in disease characteristics. They found that patients with low and high BMI could represent two clinically different subtypes. There is an increasing awareness that the clinical presentation of HS is heterogeneous, and that different phenotypes may occur. Hypothetically, HS subtypes may reflect different etiology and prognosis and therefore, may require different therapeutic approaches...
October 4, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
J L D Thomsen, A K Nørskov, C V Rosenstock
Indications for using supraglottic airway devices have widened over time and they now hold a prominent role in guidelines for difficult airway management. We aimed to describe the use of supraglottic airway devices in difficult airway management. We included adult patients undergoing general anaesthesia registered in the Danish Anaesthesia Database from 2008 to 2012 whose airway management had been recorded as difficult, defined as: ≥ 3 tracheal intubation attempts; failed tracheal intubation; or difficult facemask ventilation...
October 4, 2018: Anaesthesia
Martin Frydland, Jacob Eifer Møller, Sebastian Wiberg, Matias Greve Lindholm, Rikke Hansen, Jose P S Henriques, Ole Kristian Møller-Helgestad, Lia Evi Bang, Ruth Frikke-Schmidt, Jens Peter Goetze, Nanna Louise Junker Udesen, Jakob Hartvig Thomsen, Dagmar M Ouweneel, Laust Obling, Hanne Berg Ravn, Lene Holmvang, Lisette Okkels Jensen, Jesper Kjaergaard, Christian Hassager
AIMS: The diagnosis of cardiogenic shock depends on clinical signs of poor perfusion and low blood pressure. Lactate concentration will increase with poor tissue perfusion, and it has prognostic value in cardiogenic shock patients. We sought to assess the prognostic value of lactate concentration in subjects admitted with suspected ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: In 2094 (93%) out of 2247 consecutive suspected STEMI-subjects, lactate concentration was measured on admission...
October 3, 2018: Shock
Stephen C Bain, Ofri Mosenzon, Rosario Arechavaleta, Pawel Bogdański, Abdurrahman Comlekci, Agostino Consoli, Chaicharn Deerochanawong, Kathleen Dungan, Maria C Faingold, Michael E Farkouh, Denise R Franco, Jeppe Gram, Cristian Guja, Pankaj Joshi, Rachid Malek, Juan F Merino-Torres, Michael A Nauck, Sue D Pedersen, Wayne Huey-Herng Sheu, Robert J Silver, Cees J Tack, Nikhil Tandon, Ole K Jeppesen, Mette Strange, Mette Thomsen, Mansoor Husain
AIM: To assess the cardiovascular safety of oral semaglutide, the first tablet formulation of a glucagon-like peptide-1 receptor agonist. METHODS: PIONEER 6 is a multinational, randomised, placebo-controlled, double-blind trial in patients with type 2 diabetes (T2D) at high risk of cardiovascular events (defined as being: [1] ≥50 years and having established cardiovascular disease or moderate (Stage 3) chronic kidney disease [CKD], or [2] ≥60 years with ≥1 other cardiovascular risk factor)...
October 4, 2018: Diabetes, Obesity & Metabolism
Galinos Barmparas, Navpreet K Dhillon, James M Tatum, Kavita Patel, Gretchen M Thomsen, Russell Mason, Daniel R Margulies, Eric J Ley
BACKGROUND: Neuromuscular blockade (NMB) is often utilized in the treatment of acute respiratory distress syndrome (ARDS). Its use for a period of 48 h has been shown to improve mortality in randomized control trials. We aimed to characterize outcomes associated with a prolonged NMB. We hypothesized that the duration of NMB would not be associated with increased mortality. MATERIALS AND METHODS: This was a retrospective review from June 2014 to October 2016 of patients admitted to the surgical intensive care unit and receiving cisatracurium for ARDS...
November 2018: Journal of Surgical Research
Anders Thomsen, Sabrina Toft Hansen, Lars Lund
Scrotal diseases can be categorised in different ways: Are the patients young or old, or is the condition acute or chronic? Few organs are as easily accessible as scrotum. Nevertheless, it can be difficult to make a correct diagnosis especially in chronic patients. This review divides scrotal diseases in two groups: acute and non-acute diseases. Relevant diseases are described with symptoms, clinical findings and treatment.
October 1, 2018: Ugeskrift for Laeger
Anita Rath Sørensen, Elisabeth Bendstrup, Anders Løkke, Ingrid Louise Titlestad, Jens Ulrik Jensen, Laura Thomsen, Nassim Roberts, Pia Gjørup, Saher Shaker, Svend Gundestrup, Torgny Wilcke, Ulla Møller Weinreich, Kristoffer Marsaa
The decision to limit or discontinue treatment is a difficult issue, which all physicians will face. Timely communication with information on treatment possibilities and limitations, respectful listening to patients' and informal caregivers' wishes and early palliation is recommended in a stable phase. In some situations, it is better to stop life-prolonging treatment and optimise quality of life in patients with benign pulmonary diseases. Decision on treatment limitations or discontinuation is best taken at a conference and should be based on the patient's wishes, the disease stage and progression and potential reversible components...
September 24, 2018: Ugeskrift for Laeger
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