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Zarqa Ali, Charlotte Suppli Ulrik, Tove Agner, Simon Francis Thomsen
Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardio-vascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines...
August 15, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
Elise Harder, Louise T Thomsen, Rasmus Hertzum-Larsen, Vanna Albieri, Marie Vik Hessner, Kirsten Egebjerg Juul, Jesper Bonde, Kirsten Frederiksen, Susanne K Kjaer
BACKGROUND: Offering human papillomavirus-based self-sampling to non-participants in routine cervical cancer screening can increase screening participation. However, little is known about characteristics of women who accept self-sampling. In this population-based study, we investigated determinants for participation in self-sampling among Danish non-attenders to routine cervical cancer screening. METHODS: During 2014-2015, a random sample of screening non-participants aged 27-65 years living in the Capital Region of Denmark were invited for self-sampling...
August 14, 2018: Cancer Epidemiology, Biomarkers & Prevention
Oleg Kurtenkov, Kaire Innos, Boris Sergejev, Kersti Klaamas
Alterations in the glycosylation of serum total immunoglobulins show these antibodies to have a diagnostic potential for cancer but the disease-related Abs to the tumor-associated antigens, including glycans, have still poorly been investigated in this respect. We analysed serum samples from patients with breast carcinoma (n = 196) and controls (n = 64) for the level of Thomsen-Friedenreich (TF) antigen-specific antibody isotypes, their sialylation, interrelationships, and the avidity by using ELISA with the synthetic TF-polyacrylamide conjugate as an antigen and the sialic acid-specific Sambucus nigra agglutinin (SNA) and ammonium thiocyanate as a chaotrope...
2018: BioMed Research International
Caroline Bollars, Take Naseri, Robert Thomsen, Cherian Varghese, Kristine Sørensen, Nanne de Vries, Ree Meertens
Problem: Samoa has been struggling to address the burden of noncommunicable diseases at the health system, community and individual levels. Approach: The World Health Organization (WHO) package of essential noncommunicable disease interventions for primary health care in low-resource settings was adopted in seven villages throughout Samoa in 2015. The National Steering Committee Members designed and implemented a screening process, and local facilitators and health-care workers collected health and lifestyle data...
August 1, 2018: Bulletin of the World Health Organization
Cameron Schlegel, Lynne A Lapierre, Victoria G Weis, Janice A Williams, Izumi Kaji, Carolina Pinzon-Guzman, Nripesh Prasad, Braden Boone, Angela Jones, Hernan Correa, Shawn E Levy, Xianlin Han, Miao Wang, Kelly Thomsen, Sari Acra, James R Goldenring
Deficiency in diacylglycerol acyltransferase (DGAT1) is a rare cause of neonatal diarrhea, without a known mechanism or in vitro model. METHODS AND RESULTS: A patient presenting at our institution at 7 weeks of life with failure to thrive and diarrhea was found by whole-exome sequencing to have a homozygous DGAT1 truncation mutation. Duodenal biopsies showed loss of DGAT1 and deficits in apical membrane transporters and junctional proteins in enterocytes. When placed on a very low-fat diet, the patient's diarrhea resolved with normalization of brush border transporter localization in endoscopic biopsies...
August 10, 2018: Traffic
Sabrina Santarsia, Ana Sofia Grosso, Filipa Trovão, Jesús Jiménez-Barbero, Ana Luísa Carvalho, Cristina Nativi, Filipa Marcelo
Overexpression of the Thomsen-Friedenreich (TF) antigen in cell membrane proteins occurs in 90% of adenocarcinomas. Additionally, the binding of the TF-antigen to human galectin-3 (Gal-3), also frequently overexpressed in malignancy, promotes cancer progression and metastasis. In this context, structures that interfere with this specific interaction display the potential to prevent cancer metastasis. Herein, a multidisciplinary approach, combining the optimized synthesis of a TF-antigen mimetic with NMR, X-ray crystallography methods and isothermal titration calorimetry assays has been employed to unravel the molecular structural details that govern the Gal-3/TF-mimetic interaction...
August 9, 2018: ChemMedChem
Trine Mechta Nielsen, Metha Frøjk Juhl, Bo Feldt-Rasmussen, Thordis Thomsen
Non-adherence to multipharmacological treatment increases the risk of morbidity, mortality and hospitalization. We know little about the perspective of patients with chronic kidney disease regarding factors influencing medicine taking. This study aimed to synthesize findings from qualitative studies of patients' experiences of factors that facilitate and hinder adherence to medication. A systematic review of qualitative studies adhering to the Enhancing transparency in reporting the synthesis of qualitative research (ENTREQ) framework...
August 2018: Clinical Kidney Journal
Pascal Pujol, Pierre Vande Perre, Laurence Faivre, Damien Sanlaville, Carole Corsini, Bernard Baertschi, Michèle Anahory, Dominique Vaur, Sylviane Olschwang, Nadem Soufir, Noëlle Bastide, Sarah Amar, Michèle Vintraud, Olivier Ingster, Stéphane Richard, Pierre Le Coz, Jean-Philippe Spano, Olivier Caron, Pascal Hammel, Elisabeth Luporsi, Alain Toledano, Xavier Rebillard, Anne Cambon-Thomsen, Olivier Putois, Jean-Marc Rey, Christian Hervé, Caroline Zorn, Karen Baudry, Virginie Galibert, Joseph Gligorov, David Azria, Brigitte Bressac-de Paillerets, Nelly Burnichon, Marc Spielmann, Daniel Zarca, Isabelle Coupier, Olivier Cussenot, Anne-Paule Gimenez-Roqueplo, Sophie Giraud, Anne-Sophie Lapointe, Patricia Niccoli, Isabelle Raingeard, Muriel Le Bidan, Thierry Frebourg, Arash Rafii, David Geneviève
In oncology, the expanding use of multi-gene panels to explore familial cancer predisposition and tumor genome analysis has led to increased secondary findings discoveries (SFs) and has given rise to important medical, ethical, and legal issues. The American College of Medical Genetics and Genomics published a policy statement for managing SFs for a list of genes, including 25 cancer-related genes. Currently, there are few recommendations in Europe. From June 2016 to May 2017, the French Society of Predictive and Personalized Medicine (SFMPP) established a working group of 47 experts to elaborate guidelines for managing information given on the SFs for genes related to cancers...
August 8, 2018: European Journal of Human Genetics: EJHG
Ivana Domljanovic, Elisabeth Rexen Ulven, Trond Ulven, Rasmus P Thomsen, Anders H Okholm, Jørgen Kjems, Anne Voss, Maria Taskova, Kira Astakhova
Antigen recognition by antibodies plays an important role in human biology and in the development of diseases. This interaction provides a basis for multiple diagnostic assays and is a guide for treatments. We have developed dihydropyridine-based fluorophores that form stable complexes with double-stranded DNA and upon recognition of the antibodies to DNA (anti-DNA) provide an optical response. The fluorophores described herein have advantageous optical properties compared to those of the currently available dyes making them valuable for research and clinical diagnostics...
July 31, 2018: ACS Omega
Sabeera Haris, Chuanji Fang, Juan-Rodrigo Bastidas-Oyanedel, Kristala Jones Prather, Jens Ejbye Schmidt, Mette Hedegaard Thomsen
Bacterial contamination is one of the major challenges faced by yeast fermentation industries as the contaminating microorganisms produce lactic acid and acetic acid, which reduces the viability of yeast, and hence fermentation yields. The primary bacterial contaminants of yeast fermentations are lactic acid bacteria (LAB). This study aims to identify potential natural antibacterial fractions from raw and pretreated lignocellulosic biomasses found in Abu Dhabi, UAE, in terms of LAB inhibition capacity, allowing growth of the yeast...
August 6, 2018: AMB Express
Helle Kiellberg Larsen, Louise T Thomsen, Merete Haedersdal, Christian Dehlendorff, Søren Schwartz Sørensen, Susanne K Kjaer
Genital warts (GWs) are a risk factor for subsequent human papillomavirus (HPV)-related anogenital cancers. In this register-based, prospective cohort study, we estimated the risk of GWs in renal transplant recipients (RTRs) compared with a non-transplanted cohort. In a nationwide database, we identified first-time RTRs in Denmark during 1996-2015. For each RTR, 50 age- and sex-matched non-transplanted individuals were selected from the population registry. Information on GWs, socio-demographic characteristics, HPV vaccination, and other causes of immunosuppression was retrieved from registries...
August 6, 2018: American Journal of Transplantation
Claus Moser, Trine Rolighed Thomsen, Niels Høiby
PURPOSE OF REVIEW: The major problem for cystic fibrosis patients is the recurrent and chronic infections of the lungs, determining their prognosis. The challenge from biofilm-growing bacteria and emerging viruses urge the microbiological laboratories to develop better and faster diagnostic tools. Of these, molecular diagnostics are rapidly developing. However, beyond detecting many microorganisms, the task is to evaluate their clinical significance. This has always been a problem resulting in Koch's postulates...
July 31, 2018: Current Opinion in Pulmonary Medicine
Lena Wallensteen, Marius Zimmermann, Malin Thomsen Sandberg, Anton Gezelius, Anna Nordenström, Tatja Hirvikoski, Svetlana Lajic
No abstract text is available yet for this article.
July 2018: Hormones and Behavior
Anne-Mette Lange, David Daley, Morten Frydenberg, Tine Houmann, Lene Juel Kristensen, Charlotte Rask, Edmund Sonuga-Barke, Signe Søndergaard-Baden, Aparna Udupi, Per Hove Thomsen
OBJECTIVE: Parent training is recommended for attention-deficit/hyperactivity disorder (ADHD) in preschool children. Evidence-based interventions are important, but only if they produce better outcomes than usual care. METHOD: The authors conducted a multicenter, 2-arm, parallel-group, randomized controlled trial in routine specialist ADHD clinics in the Danish Child and Adolescent Mental Health Services. Children (N = 164, 3-7 years old) with ADHD received a well-established parent training program (New Forest Parenting Programme; n = 88) or treatment as usual (n = 76)...
August 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Kasper von Rosen, Gudjon Leifur Gunnarsson, Christina Gramkow, Jens Ahm Sørensen, Jørn Bo Thomsen
An increasing amount of evidence supports the benefits of fat grafting for breast augmentation, correction following breast-conserving surgery, breast reconstructions as well as correction of tuberous, hypoplastic and asymmetrical breasts. The aim of fat grafting is to create a breast with an aesthetic, natural appearance. In this review, we describe the most common indications for fat grafting of the breast and give an overview of the techniques in use as well as their associated risks and future perspectives...
July 30, 2018: Ugeskrift for Laeger
Soren K Thomsen, Anne Raimondo, Benoit Hastoy, Shahana Sengupta, Xiao-Qing Dai, Austin Bautista, Jenny Censin, Anthony J Payne, Mahesh M Umapathysivam, Aliya F Spigelman, Amy Barrett, Christopher J Groves, Nicola L Beer, Jocelyn E Manning Fox, Mark I McCarthy, Anne Clark, Anubha Mahajan, Patrik Rorsman, Patrick E MacDonald, Anna L Gloyn
The molecular mechanisms underpinning susceptibility loci for type 2 diabetes (T2D) remain poorly understood. Coding variants in peptidylglycine α-amidating monooxygenase (PAM) are associated with both T2D risk and insulinogenic index. Here, we demonstrate that the T2D risk alleles impact negatively on overall PAM activity via defects in expression and catalytic function. PAM deficiency results in reduced insulin content and altered dynamics of insulin secretion in a human β-cell model and primary islets from cadaveric donors...
July 27, 2018: Nature Genetics
Hannah Trøstrup, Christian Johann Lerche, Lars Jackie Christophersen, Kim Thomsen, Peter Østrup Jensen, Hans Petter Hougen, Niels Høiby, Claus Moser
No abstract text is available yet for this article.
November 30, 2017: Pathogens and Disease
Lydia P Bakalova, Christina M Andreasen, Jesper Skovhus Thomsen, Annemarie Brüel, Ellen-Margrethe Hauge, Birgitte Jul Kiil, Jean-Marie Delaisse, Thomas Levin Andersen, Mariana E Kersh PhD
During aging and in osteoporosis, cortical bone becomes more porous, making it more fragile and susceptible to fractures. The aim of this study was to investigate the intracortical compression- induced strain energy distribution, and determine whether intracortical pores associated with high strain energy density (SED) in the surrounding bone matrix have a different morphology, distribution and remodeling characteristics than matrix with normal SED. Fibular diaphyseal specimens from 20 patients undergoing a jaw reconstruction (age range 41-75 years, 14 men and 6 women) were studied...
July 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Rikke Larsen Rasmussen, Charlotte Overgaard, Henrik Bøggild, Louise Lund Holm Thomsen
Health-risk behaviour like physical inactivity is more evident in deprived neighbourhoods than in nondeprived neighbourhoods, and in the former knowledge is lacking as to what causes effects in interventions on physical activity. A possible contribution to physical activity interventions is community engagement, which has been shown to be effective for changing health-risk behaviour, but more knowledge is needed on "the active ingredients" or mechanisms that make interventions work. The aim of this study was to give more insight into the possible mechanisms within an intervention on physical activity using community engagement...
July 26, 2018: Health & Social Care in the Community
Georgina Berridge, David A Menassa, Teresa Moloney, Patrick J Waters, Imogen Welding, Selina Thomsen, Sameer Zuberi, Roman Fischer, A Radu Aricescu, Michael Pike, Russell C Dale, Benedikt Kessler, Angela Vincent, Ming Lim, Sarosh R Irani, Bethan Lang
OBJECTIVE: To identify neuronal surface antibodies in opsoclonus myoclonus ataxia syndrome (OMAS) using contemporary antigen discovery methodology. METHODS: OMAS patient serum immunoglobulin G immunohistochemistry using age-equivalent rat cerebellar tissue was followed by immunoprecipitation, gel electrophoresis, and mass spectrometry. Data are available via ProteomeXchange (identifier PXD009578). This generated a list of potential neuronal surface cerebellar autoantigens...
July 25, 2018: Neurology
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