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Glaucoma diagnosis

Daniela R de Oliveira, Camila V Ventura, Bruno L B Esporcatte, Carolina P B Gracitelli, Natalia de Carvalho Dias, Liana O Ventura, Rubens Belfort, Christiane Rolim-de-Moura
PURPOSE: To perform a glaucoma work-up in infants with congenital Zika syndrome (CZS). PATIENT AND METHODS: This cross-sectional study included 188 eyes of 107 children (1.1 ± 0.3▒y [range, 0.3-1.8▒y]) with CZS. The confirmation of the syndrome was possible in 77/107 (72.0%) of the enrolled infants based on positive immunoglobulin M antibody capture enzyme-linked immunosorbent assay for Zika virus in the cerebrospinal fluid. All infants underwent a complete ophthalmic examination and bilateral fundus imaging was captured using a wide-angle digital fundus camera (RetCam™; Natus Medical Inc...
December 10, 2018: Journal of Glaucoma
Henrietta Ho, Yih-Chung Tham, Miao Li Chee, Yuan Shi, Nicholas Y Q Tan, Kah-Hie Wong, Shivani Majithia, Carol Y Cheung, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
PURPOSE: To describe variations in retinal nerve fiber layer (RNFL) thickness based on spectral-domain OCT (SD-OCT) in a multi-ethnic Asian population. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Ethnic Chinese, Malay and Indian adults, aged greater than 48 years without glaucoma, recruited from the Singapore Epidemiology of Eye Diseases (SEED) Study. METHODS: All participants underwent standardized systemic and ocular examinations...
December 4, 2018: Ophthalmology
Nkiru N Kizor-Akaraiwe
PURPOSE: To determine uptake, adherence and influencing factors to follow-up care by newly diagnosed glaucoma patients from free eye screening exercise. METHODS: The study was a cross-sectional survey of newly diagnosed glaucoma patients during free eye screenings carried out in March and October, 2016 in Enugu, Nigeria. Data on participants were analyzed after a minimum of 6 months from the screening for uptake and adherence to follow-up care. Qualifying patients had questionnaires administered to them by phone interview...
December 6, 2018: Ophthalmic Epidemiology
Leonardo Seidi Shigueoka, José Paulo Cabral de Vasconcellos, Rui Barroso Schimiti, Alexandre Soares Castro Reis, Gabriel Ozeas de Oliveira, Edson Satoshi Gomi, Jayme Augusto Rocha Vianna, Renato Dichetti Dos Reis Lisboa, Felipe Andrade Medeiros, Vital Paulino Costa
PURPOSE: To test the ability of machine learning classifiers (MLCs) using optical coherence tomography (OCT) and standard automated perimetry (SAP) parameters to discriminate between healthy and glaucomatous individuals, and to compare it to the diagnostic ability of the combined structure-function index (CSFI), general ophthalmologists and glaucoma specialists. DESIGN: Cross-sectional prospective study. METHODS: Fifty eight eyes of 58 patients with early to moderate glaucoma (median value of the mean deviation = -3...
2018: PloS One
Denny Marcos Garcia, Fabiola Reis de Oliveira, Carolina Maria Módulo, Jacqueline Faustino, Amanda Pires Barbosa, Monica Alves, Eduardo Melani Rocha
PURPOSE: Dry Eye Disease (DED) is part of several conditions, including Sjögren's syndrome (SS) and no single test to diagnosis DED. The present study intends to evaluate whether a set of signs and symptoms of DED can distinguish: a) SS from other non-overlapping systemic diseases related to DED; b) primary and secondary SS. METHODS: 182 consecutive patients with DED were evaluated under five groups: SS, graft-versus-host disease (GVHD), Graves' orbitopathy (GO), diabetes mellitus (DM), glaucoma under treatment with benzalkonium chloride medications (BAK)...
2018: PloS One
R Greslechner, I Oberacher-Velten
BACKGROUND: Glaucoma due to elevated episcleral venous pressure is a rare and difficult to treat form of secondary open angle glaucoma. OBJECTIVE: The pathophysiology, clinical findings, differential diagnosis and treatment options are discussed. Radius-Maumenee syndrome, Sturge-Weber syndrome and carotid-cavernous sinus fistulas are covered in particular. MATERIAL AND METHODS: A literature search was conducted in the PubMed database. RESULTS: In the course of the diagnostics potentially severe diseases, such as carotid-cavernous sinus fistulas have to be ruled out...
November 30, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Pravda Chaturvedi, Arvind Chauhan, Punit Kumar Singh
PURPOSE: An assessment of variation in Macular Volume and RNFL Thickness in myopes using OCT, and their significance for early diagnosis of Primary Open Angle Glaucoma(POAG). MATERIALS AND METHOD: Total of 122 eyes of 61 Indian Myopic subjects of both sex and various age groups underwent retinal nerve fiber layer thickness, macular volume in 6mm analysis by Rtvue Avanti SD-OCT, Optovue Technology V6.1.1,after taking due consent from ethical committee. Subjects were divided into two groups based on their refractive error, Group A <6 D and Group B >6D...
September 2018: Oman Journal of Ophthalmology
Anuradha Raj, Renu Dhasmana, Harsh Bahadur
BACKGROUND: Glaucoma is the leading cause of blindness after penetrating keratoplasty (PK) and its early diagnosis and management is mandatory to salvage the graft. AIMS: This study aimed to evaluate the incidence and risk factors for post penetrating keratoplasty glaucoma (PKG). METHODS: Data of 155 eyes of 155 patients were reviewed retrospectively who underwent PK from March 2013 to February 2016. Data were analyzed from recipient records for recipient age, sex, indications, type of PK, lens status, recipient graft size or any additional procedure...
September 2018: Oman Journal of Ophthalmology
Sara David, Kathleen De Waele, Bram De Wilde, Franny Faes, Olivier Vanakker, Sophie Walraedt, Agnieszka Prytuła
We describe a boy who presented with neonatal hypotonia, followed by delayed motor development and growth impairment. Further evaluation revealed rickets caused by proximal renal tubular dysfunction. At age 3, the boy exhibited dysmorphic features and bilateral cataract. Genetic analysis of the OCRL gene showed a novel variant in exon 13: c.1250T>A, p.Val417Asp; in silico and segregation analysis confirmed the variant to be pathogenic, compatible with the diagnosis of the oculocerebrorenal syndrome of Lowe...
December 3, 2018: Acta Clinica Belgica
Jonathan Denniss, Andrew Turpin, Allison M McKendrick
Combining information from optical coherence tomography (OCT) imaging and visual field testing is useful in the clinical assessment and monitoring of patients with glaucoma. Measurements of retinal nerve fibre layer thickness or neuroretinal rim width taken around the optic nerve head may be related to the visual field using a structure-function map. In this review, the structure-function mapping methods in clinical use are discussed. Typical clinical maps provide a population average, 'one size fits all' representation, but in recent years methods for customising structure-function maps to individual eyes have been developed and these are reviewed here...
November 29, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Uday Kumar Addepalli, Ganesh B Jonnadula, Chandra Sekhar Garudadri, Rohit C Khanna, Eric B Papas
PURPOSE: To report the prevalence of primary glaucoma as identified by study optometrists of the L. V. Prasad Eye Institute - Glaucoma Epidemiology and Molecular Genetics Study (LVPEI-GLEAMS). METHODS: Two study optometrists and a total number of 3833 individuals participated in the LVPEI-GLEAMS. All subjects underwent a complete medical history and comprehensive eye examination including slit lamp photography, imaging of anterior and posterior segment, frequency doubling technology and standard automated perimetry including gonioscopy with a Sussman 4 mirror goniolens, post dilated evaluation of the optic disc and fundus was done with a 90 D lens by the study optometrist...
November 29, 2018: Ophthalmic Epidemiology
Jin Mo Ahn, Sangsoo Kim, Kwang-Sung Ahn, Sung-Hoon Cho, Kwan Bok Lee, Ungsoo Samuel Kim
PURPOSE: To build a deep learning model to diagnose glaucoma using fundus photography. DESIGN: Cross sectional case study Subjects, Participants and Controls: A total of 1,542 photos (786 normal controls, 467 advanced glaucoma and 289 early glaucoma patients) were obtained by fundus photography. METHOD: The whole dataset of 1,542 images were split into 754 training, 324 validation and 464 test datasets. These datasets were used to construct simple logistic classification and convolutional neural network using Tensorflow...
2018: PloS One
Loka Thangamathesvaran, Elliot Crane, Kunjal Modi, Albert S Khouri
Introduction: Glaucoma is a chronic optic neuropathy with increasing global prevalence, necessitating trainees in ophthalmology to be well-trained in the surgical modalities used to manage glaucoma. It is also important to not compromise patient safety and treatment efficacy for training and education. The purpose of our analysis is to compare postoperative outcomes of resident versus (vs.) attending performed tube shunt surgeries (TS). Materials and methods: A retrospective, chart review was performed of patients who had undergone TS between 2009 and 2015 at Rutgers University in Newark, New Jersey, USA...
May 2018: Journal of Current Glaucoma Practice
A B González Escobar, A Alberte González, A Ibañez García, M Lorenzo Soto, S Gismero Moreno
Sclerochoroidal calcification (SCC) is uncommon and benign. It is usually detected in a routine examination, finding multiple yellow-white lesions in the upper temporal region of the retina in middle-aged and elderly men. A case report is presented of a 79 year-old male patient, who during a routine examination with a pseudoexfoliative glaucoma in the right eye, as well as raised white-yellow subretinal lesions in the upper temporal region in both eyes. After establishing hypotensive treatment and performing autofluorescence, optical coherence tomography (OCT), ultrasound, ocular computed tomography (CT) and complete laboratory analysis, idiopathic SCC was diagnosed...
November 13, 2018: Archivos de la Sociedad Española de Oftalmología
L Hrčková, P Mojžiš, P Žiak
CASE-REPORT: The author presents case report of acute induced myopia with mild intraocular pressure elevation by young patient using trazodone. The presentation is completed with the documentation of anterior chamber depth and angle changes by using and after discontinuation of trazodone. CONCLUSION: Acute transient myopia may be rare side effect of systemic used drugs in predisposed patients. Early and correct diagnosis is very important, because induced myopia may be accompanied by acute angle-closure glaucoma or supraciliary choroidal effusion...
2018: Ceská a Slovenská Oftalmologie
Zeinab Ghassabi, Jamshid Shanbehzadeh, Kouros Nouri-Mahdavi
Segmentation of retinal anatomical features such as optic nerve head (ONH) and optic cup, the brightest area in the center of ONH which is devoid of neural elements, is a prerequisite for computer-aided diagnosis and follow-up of glaucoma. The ONH segmentation methods, which imposed shape and intensity constraints, are unable to identify ONH and optic cup boundaries at the same time. On the other hand, recent efficient supervised learning-based methods, which provide a unified system, require combination of many informative features as their inputs, as well as ground truth for the training phase...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
W J Dang, X Zhang
Glaucoma can lead to irreversible visual impairment. The pathogenesis of glaucoma is complicated and it is difficult to diagnose early. As an objective and functional examination tool, visual electrophysiology has its own advantages to detect early glaucomatous damage. It can indicate early functional degeneration of retinal ganglion cells and can direct doctors to diagnose and give treatment to glaucoma patients. It has been proved that the pattern electroretinogram, photopic negative response and multifocal electroretinogram can provide most of the information in the early diagnosis of glaucoma...
November 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
X H Sun, Y Dai
Glaucoma-related retinal imaging using frequency domain optical coherence tomography (OCT) has become an important but not the only basis for the diagnosis and follow-up of glaucoma. The circumpapillary retinal nerve fiber layer thickness and the macular ganglion cell thickness are two commonly used structural parameters in glaucoma. Their diagnostic efficacy is similar, but each has different influencing factors. Clinically, these two parameters should be analyzed together to improve the specificity and sensitivity for detecting glaucomatous optic nerve damage...
November 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Yuhong Chen, Chen Qiu, Shaohong Qian, Junyi Chen, Xueli Chen, Li Wang, Xinghuai Sun
To investigate the association of known candidate genes with the visual field (VF) progression of primary open angle glaucoma (POAG) in a Han Chinese population. We included 440 POAG patients in this study. Fourteen previously reported single nucleotide polymorphisms (SNPs) at five different gene regions ( TGFBR3-CDC7 , TMCO1 , CDKN2B-AS1 , ATOH7 , and SIX1/SIX6 ) were genotyped. Age at diagnosis, gender, intraocular pressure (IOP), mean defect (MD) of VF, vertical cup disk ratio (VCDR), best corrected visual acuity (BCVA), central corneal thickness (CCT), and axial length (AL) were recorded at baseline...
2018: Frontiers in Genetics
L De Simone, L Belloni, R Aldigeri, A Zerbini, V Mastrofilippo, A Sangiovanni, M Parmeggiani, L Fontana, Luca Cimino
PURPOSE: The diagnosis of cytomegalovirus (CMV) anterior uveitis in immunocompetent patients requires confirmation by polymerase chain reaction (PCR) analysis and/or intraocular antibody index (AI) assay. In this study, we analyzed the different contributions of PCR and AI to CMV diagnosis by performing one single aqueous tap. METHODS: A retrospective chart review was conducted of HIV-negative patients attending the Ocular Immunology Unit of Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy, from March 2015 to April 2018 with a diagnosis of hypertensive anterior granulomatous uveitis compatible with suspected CMV etiology...
November 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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