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Glaucoma diagnosis

Johan Aspberg, Anders Heijl, Gauti Jóhannesson, Christina Lindén, Sabina Andersson, Boel Bengtsson
PURPOSE: To assess the intraocular pressure (IOP)-reducing effect of latanoprost in treatment-naïve patients with newly detected open-angle glaucoma with no restriction of the level of untreated IOP. METHODS: Eighty-six patients (105 eyes) with a diagnosis of open-angle glaucoma received IOP-lowering therapy with latanoprost. The IOP reduction 1 and 3 months after initiation of treatment was recorded. RESULTS: Mean untreated IOP for all eyes was 26...
August 14, 2018: Journal of Glaucoma
Yanin Suwan, Samantha Rettig, Sung Chul Park, Apichat Tantraworasin, Lawrence S Geyman, Keith Effert, Luis Silva, Ravivarn Jarukasetphorn, Robert Ritch
PURPOSE: In a myopic population, we investigated the occurrence of circumpapillary retinal nerve fiber layer (RNFL) segmentation errors that required manual correction in optical coherence tomography (OCT) and its effect on glaucoma diagnostic capability of OCT. MATERIALS AND METHODS: Myopic subjects (spherical equivalent refractive error <-3 diopters) with and without primary open-angle glaucoma were recruited. Three circumpapillary RNFL scans with diameters of 3...
August 14, 2018: Journal of Glaucoma
Ying Mao, Hai Xia Bai, Bin Li, Xiao Lin Xu, Fei Gao, Zhi Bao Zhang, Jost B Jonas
BACKGROUND: To assess the dimensions of Brücke's muscle, as the longitudinal portion, and of Müller's muscle and Iwanoff's muscle combined as circular and radial/reticular portions of the ciliary muscle. METHODS: The histomorphometric study included human globes that had been enucleated due to an ocular tumor or end-stage glaucoma. After immunohistochemical staining of the ciliary muscles, the histology slides were examined under a light microscope applying a digitized image analysis system...
August 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Rasheeda Bashir, Khazeema Yousaf, Hafsa Tahir, Marukh Sanai, Seema Qayyum, Shagufta Naz, Sadaf Naz
OBJECTIVE: To explore the spectrum of Cytochrome P450 1B1 gene variants and genotype-phenotype correlations in families affected with primary congenital glaucoma. METHODS: The cross-sectional study was performed at the Department of Biotechnology, Lahore College for Women University, Lahore, and the School of Biological Sciences, University of the Punjab, Lahore, Pakistan, from February 2015 to October 2016. Six consanguineous families having individuals affected with primary congenital glaucoma were recruited from different hospitals of the city...
August 2018: JPMA. the Journal of the Pakistan Medical Association
Rosanna Dammacco, Pasquale Procaccio, Vito Racanelli, Angelo Vacca, Franco Dammacco
PURPOSE: To assess the prevalence of the ocular manifestations related to the disease and/or ascribable to the administration of potentially toxic drugs in a cohort of 98 patients with systemic lupus erythematosus (SLE). METHODS: Retrospective, observational study reporting the experience of two tertiary referral centers. RESULTS: Overall, an ocular involvement was detected in 29 patients (29.6%), sometimes preceding of months the diagnosis of SLE, more often revealed at diagnosis or throughout its course...
August 10, 2018: Ocular Immunology and Inflammation
Mohammad Pakravan, Hamed Esfandiari, Nassim Amouhashemi, Amir Veisi, Pooya Torkian, Shahin Yazdani
Purpose: To evaluate the safety and efficacy of clear corneal approach irido-zonulo-hyaloido-vitrectomy, which we named "mini-vitrectomy," in the management of pseudophakic aqueous misdirection. Methods: In this retrospective, non-comparative interventional case series, 24 eyes with diagnosis of pseudophakic aqueous misdirection were enrolled. Medical therapy with cycloplegics and laser therapy, including posterior capsulotomy and hyaloidotomy, was not effective in the management of the condition...
July 2018: Journal of Ophthalmic & Vision Research
Sarah M Jacobs, Raghu C Mudumbai, A J Amadi
Purpose: This study evaluates the radiographic appearance of lacrimal gland tissue after placement of a glaucoma drainage implant (GDI) to characterize the impact of the device on the gland's imaging patterns. Methods: We performed retrospective chart review of departmental records at two urban academic medical centers, which were systematically searched using procedure codes to identify adult glaucoma patients who underwent unilateral superotemporal GDI from January 1995 to December 2015...
July 2018: Journal of Ophthalmic & Vision Research
Megan Cann, Athimalaipet V Ramanan, Andrew Crawford, Andrew D Dick, Sarah L N Clarke, Fatima Rashed, Catherine M Guly
BACKGROUND: There is a paucity of data on the ocular outcomes in paediatric non-infectious uveitis since the introduction of the biologic agents. The purpose of this study was to outline the clinical characteristics of children with non-infectious uveitis and determine the visual outcomes and ocular complication rates in the modern era. METHODS: Children with non-infectious uveitis from January 2011 to December 2015 were identified. Data was collected at baseline, 1, 3, 5, and 10 years post diagnosis...
August 6, 2018: Pediatric Rheumatology Online Journal
Jie Peng, Qi Zhang, Xinchun Long, Jia Zhang, Qiujing Huang, Yian Li, Kaiqin She, Peiquan Zhao
PURPOSE: To characterize ocular manifestations in a cohort of paediatric patients with incontinentia pigmenti (IP) and to define the guidelines for grading of IP-associated retinopathy (IPR). METHODS: This retrospective review was performed on patients under the age of 18 years with a diagnosis of IP. Data included demographics, medical history, ocular examination, and accessory examination. Ocular and systemic physical examinations of the parents were carried out to determine the familial history...
August 3, 2018: Acta Ophthalmologica
Milica A Margeta, Eleonora M Lad, Alan D Proia
PURPOSE: Prior research in animal models has shown that macrophages and microglia play an important role in pathogenesis of glaucoma, but the phenotype and distribution of macrophages in human glaucomatous tissue have not been sufficiently characterized. METHODS: We analyzed H&E, CD68-, and CD163-immunostained slides from 25 formaldehyde-fixed, paraffin-embedded autopsy eyes: 12 control eyes and 13 eyes with glaucoma. The diagnosis of glaucoma was made based on a history of glaucoma as reported in the medical record and histological changes characteristic of glaucoma...
August 2, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Andrew F Smith, Guy Negretti, Aaron Mascaro, Desta Bokre, Helen Baker, Kazim Dhalla, Ian E Murdoch
PURPOSE: A review of the effectiveness, costs, and cost-effectiveness of detection and treatment strategies for glaucoma control in Sub-Saharan Africa (SSA) was conducted. METHODS: Detailed searches were performed using the Ovid Medline, Ovid Embase, The Cochrane Library, Web of Science, Scopus, and LILACS databases up to September 2016. The key Medical Subject Heading search terms used included glaucoma, diagnosis, treatment, effectiveness, costs, cost-effectiveness, and Sub-Saharan Africa...
July 30, 2018: Ophthalmic Epidemiology
Eugene A Lowry, Steven L Mansberger
PURPOSE: To determine the proportion of patients in the US population who are receiving long-term pressure lowering medication but deny having a diagnosis of glaucoma or elevated intraocular pressure. METHODS: The National Health and Nutrition Examination Survey (NHANES) is a home-based survey of a cross-sectional, representative, stratified sample of the US population every two years. Questions on prescription medication use are asked every survey cycle and patients were questioned whether they had ever been diagnosed with glaucoma or elevated intraocular pressure in the 2005-2006 and 2007-2008 surveys...
July 27, 2018: Journal of Glaucoma
Erin R Sherman, Malinda Cafiero-Chin
Uveitic glaucoma is a range of disorders that results in optic nerve damage from elevated intraocular pressure secondary to intraocular inflammation. As compared to primary open angle glaucoma, uveitic glaucoma is associated with a more aggressive disease course caused by very high intraocular pressure levels that wax and wane. Diagnosis is often based on clinical presentation, disease course, and associated systemic manifestations. Diagnostic imaging plays an important role in both diagnosis and management...
July 29, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Sara Touhami, Lise Qu, Martina Angii, Magdalena Bojanova, Valérie Touitou, Phuc Lehoang, Flore Rozenberg, Bahram Bodaghi
PURPOSE: To report the characteristics of cytomegalovirus anterior uveitis (CMV AU) and the comparative response to two types of antiviral induction treatments. DESIGN: Retrospective, consecutive case series. METHODS: Consecutive immunocompetent patients with PCR+ CMV AU were included. For each patient, best corrected visual acuity (BCVA), intraocular pressure (IOP), clinical characteristics at baseline and latest visit, and number of relapses were recorded...
July 25, 2018: American Journal of Ophthalmology
Yuanbo Liang, Junhong Jiang, Wen Ou, Xianyao Peng, Ruizhu Sun, Xiang Xu, Juanyuan Yang, Cheng Hu, Cong Ye, Nathan Congdon, Fan Lu
PURPOSE: To assess differences in clinical and demographic characteristics between glaucoma patients identified by community screening and those newly diagnosed in hospital in a Chinese setting. DESIGN: Prospective comparative cohort study. METHODS: 373 patients identified with glaucoma among 27,000 persons undergoing community screening were enrolled as the Screening group. The Clinic group consisted of 119 consecutively-presenting, newly-diagnosed glaucoma patients in hospital...
July 24, 2018: American Journal of Ophthalmology
Keith R Martin, Kaweh Mansouri, Robert N Weinreb, Robert Wasilewicz, Christophe Gisler, Jean Hennebert, Dominique Genoud
PURPOSE: To test the hypothesis that contact lens sensor (CLS)-based 24-hour profiles of ocular volume changes contain information complementary to intraocular pressure (IOP) to discriminate between primary open angle glaucoma (POAG) and healthy (H) eyes. DESIGN: Development and evaluation of a diagnostic test with machine learning. SUBJECTS: From 435 subjects (193 healthy and 242 POAG), 136 POAG and 136 age-matched healthy subjects were selected...
July 24, 2018: American Journal of Ophthalmology
Fábio B Daga, Carolina P B Gracitelli, Alberto Diniz-Filho, Felipe A Medeiros
BACKGROUND/AIMS: To investigate whether subjects with preperimetric glaucoma exhibit decline in patient-reported vision-related quality of life (QoL) compared with healthy individuals. METHODS: This cross-sectional study included 45 patients with preperimetric glaucoma, 102 patients with perimetric glaucoma and 81 healthy controls. Perimetric glaucoma was defined by the presence of repeatable abnormal standard automated perimetry tests and corresponding optic nerve damage in at least one eye...
July 26, 2018: British Journal of Ophthalmology
Linxin Zhu, Bing Liu, Jingxiang Zhong
BACKGROUND: To report a case of a carotid-cavernous fistula (CCF) that occurred after a motor vehicle accident and review the uniqueness of this case and the main confusing points for the diagnosis of such cases. CASE PRESENTATION: A 22-year-old man complained of left eyelid swelling, eye redness, visual decrease and occasional headache after motor vehicle accident 4 months prior during which he experienced a head injury. He was initially thought to have glaucoma, but he was finally diagnosed with a right CCF based on magnetic resonance imaging (MRI) and digital subtraction angiography (DSA)...
July 25, 2018: BMC Ophthalmology
Jong Youn Moon, Hyung Jun Kim, Yoon Hyung Park, Tae Kwann Park, Eun-Cheol Park, Chan Yun Kim, Si Hyung Lee
We aimed to investigate the risks of Alzheimer's (AD) and Parkinson's disease (PD) in the 10 years following diagnosis of open-angle glaucoma (OAG) using a nationwide cohort. This propensity score-matched retrospective cohort study included 1,025,340 subjects from the Korean National Health Insurance Service National Sample Cohort database. The OAG group (n = 1,469) included patients who were initially diagnosed with OAG between 2004 and 2007, and the subjects in the comparison group were matched in a 1:5 ratio using propensity scores...
July 24, 2018: Scientific Reports
Syed Shoeb Ahmad
Glaucoma suspects are controversial clinical dilemmas. These individuals harbor certain risk factors or demonstrate some clinical features suggestive of an increased probability to develop glaucomatous optic atrophy in the future. These characteristics range from high intraocular pressure; optic disc, visual field, or retinal nerve fiber layer abnormalities; or abnormal angles to a positive family history of glaucoma and other risk factors. Individuals having these characteristics should be assessed diligently before a diagnosis of glaucoma is made...
April 2018: Taiwan Journal of Ophthalmology
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