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Glaucoma diagnosis

Teresa C Chen, Ambika Hoguet, Anna K Junk, Kouros Nouri-Mahdavi, Sunita Radhakrishnan, Hana L Takusagawa, Philip P Chen
PURPOSE: To review the current published literature on the use of spectral domain (SD) OCT to help detect changes associated with the diagnosis of glaucoma. METHODS: Searches of the peer-reviewed literature were conducted on June 11, 2014, November 7, 2016, August 8, 2017, and April 19, 2018, in the PubMed and Cochrane Library databases and included only articles published since the last glaucoma imaging Ophthalmic Technology Assessment, which included articles up until February 2006...
November 2018: Ophthalmology
Jean-Claude Mwanza, Samantha E Tulenko, Keith Barton, Leon W Herndon, Elizabeth Mathenge, Alyson Hall, Hanna Y Kim, Graham Hay-Smith, Donald L Budenz
PURPOSE: To determine the incidence of open-angle glaucoma (OAG) and its risk factors in the Tema Eye Survey, a population-based eye survey in Ghana, West Africa. DESIGN: Longitudinal observational population-based study. PARTICIPANTS: One thousand two hundred and five out of 1500 subjects aged 40 years or older, randomly selected from 5603 subjects originally drawn from the population and who had undergone a baseline examination. METHOD: All participants underwent baseline and follow-up ophthalmologic examinations 8 years apart...
October 11, 2018: Ophthalmology
R Doyle Stulting, Jonathan H Lass, Mark A Terry, Beth Ann Benetz, Nathan Cohen, Allison R Ayala, Maureen G Maguire, Christopher Croasdale, Yassine J Daoud, Steven P Dunn, Kenneth M Goins, Pankaj C Gupta, Marian S Macsai, Shahzad I Mian, Sudeep Pramanik, Jennifer Rose-Nussbaumer, Jonathan C Song, Walter J Stark, Alan Sugar, David D Verdier, Loretta B Szczotka-Flynn
PURPOSE: To identify factors related to graft rejection following Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS). DESIGN: Cohort study within a multicenter randomized clinical trial. METHODS: 1330 eyes of 1090 subjects undergoing DSAEK were randomized to receive a donor cornea with preservation time (PT) of 0-7 days (N=675) or 8-14 days (N=655) and followed for three years. Central endothelial cell density (ECD) was determined by a central image analysis reading center...
October 8, 2018: American Journal of Ophthalmology
M Reza Razeghinejad, Daniel Lee
Normal tension glaucoma (NTG) is a diagnosis assigned when characteristic glaucomatous structural and functional optic nerve defects are present in the setting of intraocular pressures (IOP) measurements below 21 mm Hg. Spot IOP measurements are generally obtained in the office during business hours and often determine who is classified as having "normal",pressures. Reduction of IOP has been the cornerstone of anti-glaucoma treatment in primary open-angle glaucoma and NTG and its therapeutic effect has been well established...
October 6, 2018: Survey of Ophthalmology
Won Hyuk Oh, Bum Gi Kim, Haksu Kyung, Joo Hwa Lee
PURPOSE: To investigate the prevalence of normal intraocular pressure (IOP) at first visit among patients with primary angle closure glaucoma (PACG) and their ocular characteristics. PATIENTS AND METHODS: We retrospectively reviewed patients with PACG in a referral center. According to untreated IOP, we divided PACG eyes into two groups: those with normal IOP and those with high IOP (>21▒mmHg) at the first visit. RESULTS: One hundred sixty eyes of 160 Korean PACG patients were included...
October 8, 2018: Journal of Glaucoma
Piotr Syga, Cezary Sieluzycki, Patrycja Krzyzanowska-Berkowska, D Robert Iskander
OBJECTIVE: A fully automated method for delineation of the lamina cribrosa in optical coherence tomography (OCT) is proposed. It assesses the 3D shape of the lamina cribrosa in-vivo, based on a series of OCT B-scans. METHODS: The algorithm has several image processing steps and it is based on active contour detection performed along three orthogonal directions of the B-scan data cuboid. Further, the delineated 3D lamina cribrosa shape is parameterized with a fourth-order polynomial of two variables, P[x, y] using the least-squares method...
October 4, 2018: IEEE Transactions on Bio-medical Engineering
Ewa Kosior-Jarecka, Dominika Wróbel-Dudzińska, Urszula Łukasik, Tomasz Żarnowski
AIM: The aim of this observational study was to evaluate the epidemiology of disc haemorrhages (DH) in Polish patients with normal tension glaucoma (NTG) and their association with some risk factors. MATERIAL AND METHODS: The group studied consisted of 274 Caucasian patients with NTG (410 eyes) divided into those with disk haemorrhages (DH+, = 94 eyes in 81 patients) and those without disc haemorrhages (DH-, = 316 eyes in 193 patients). Ophthalmic examinations with visual field (VF) testing were carried out in these patients every 3 months for at least 18 months...
October 3, 2018: Acta Ophthalmologica
Tanzila Saba, Syedia Tahseen Fatima Bokhari, Muhammad Sharif, Mussarat Yasmin, Mudassar Raza
Glaucoma is a neurodegenerative illness and is considered as a standout amongst the most widely recognized reasons for visual impairment. Nerve's degeneration is an irretrievable procedure, so the diagnosis of the illness at an early stage is an absolute requirement to stay away from lasting loss of vision. Glaucoma effected mainly because of increased intraocular pressure, if it is not distinguished and looked early, it can result in visual impairment. There are not generally evident side effects of glaucoma; thus, patients attempt to get treatment just when the seriousness of malady is advanced altogether...
October 3, 2018: Microscopy Research and Technique
Christopher Welsh, Sina Khalili, Lili-Naz Hazrati, Kamiar Mireskandari
PURPOSE: To describe the clinical, anterior segment optical coherence tomography (OCT) and histopathological features of 2 infants with congenital corneal opacities (CCOs) and undiagnosed trisomy 8 mosaicism syndrome (T8mS). METHODS: This is a retrospective case report documenting ocular and systemic findings, imaging, pathology and management of 2 patients with T8mS. RESULTS: An 11-month-old white male infant and a 4-week-old Asian female were initially seen for unilateral and bilateral CCOs, respectively...
September 27, 2018: Cornea
R Araújo-Miranda, A Lanzagorta
CASE REPORT: The case is presented of a patient referred to us with suspicion of a ciliary body melanoma due to a pigmented lesion in iris root of left eye, associated with high intraocular pressure, despite maximal topical and systemic medication. The systematic workup revealed unilateral changes in the corneal endothelium, compatible with an iridocorneal syndrome. An Ahmed® valve was inserted, achieving sustained control of intraocular pressure and visual field defects. DISCUSSION: Iridocorneal syndromes are a wide and heterogeneous group of diseases, in which endothelial cells grow over the trabeculum, leading to an increase in intraocular pressure...
September 26, 2018: Archivos de la Sociedad Española de Oftalmología
Chunlan Yang, Min Lu, Yanhua Duan, Bing Liu
BACKGROUND: Optic cup is an important structure in ophthalmologic diagnosis such as glaucoma. Automatic optic cup segmentation is also a key issue in computer aided diagnosis based on digital fundus image. However, current methods didn't effectively solve the problem of edge blurring caused by blood vessels around the optic cup. METHODS: In this study, an improved Bertalmio-Sapiro-Caselles-Ballester (BSCB) model was proposed to eliminate the noising induced by blood vessel...
September 26, 2018: Biomedical Engineering Online
David C Musch, Leslie M Niziol, Nancy K Janz, Brenda W Gillespie
PURPOSE: To characterize longitudinal trends and factors predictive of depressive symptoms following glaucoma diagnosis in Collaborative Initial Glaucoma Treatment Study (CIGTS) participants. DESIGN: Cohort study using follow up data from a clinical trial. METHODS: 607 participants with newly-diagnosed open-angle glaucoma were enrolled at 14 clinical centers in the United States from October 1993 through April 1997, randomized to treatment with medication or surgery, and followed every 6 months through 2004...
September 21, 2018: American Journal of Ophthalmology
Christina Lindén, Anders Heijl, Gauti Jóhannesson, Johan Aspberg, Sabina Andersson Geimer, Boel Bengtsson
PURPOSE: To study newly diagnosed glaucoma patients given mono- or multi-therapy regarding differences in initial intraocular pressure (IOP) reduction, target IOP levels reached and influence of untreated baseline IOP on IOP reduction. METHODS: Patients newly diagnosed with manifest primary open-angle glaucoma and included in the Glaucoma Intensive Treatment Study (GITS) were randomized to immediate intensive treatment with any of three different IOP-lowering substances supplied in two bottles plus 360° laser trabeculoplasty or to conventional stepwise treatment starting with a single-drug...
September 21, 2018: Acta Ophthalmologica
A S Ma, J R Grigg, R V Jamieson
Disorders of the anterior segment of the eye encompass a variety of clinical presentations including aniridia, Axenfeld and Rieger anomalies, primary congenital glaucoma, Peters anomaly, as well as syndromal associations. These conditions have a significant impact on vision due to disruption of the visual axis, and also secondary glaucoma which occurs in over 50% of patients. Ocular anterior segment disorders occur due to a complex interplay of developmental, embryological and genetic factors, and often have phenotypic overlaps and genetic heterogeneity...
September 21, 2018: Human Genetics
Brian M Besch, Karen Curtin, Robert Ritch, R Rand Allingham, Barbara M Wirostko
Importance: Exfoliation syndrome (XFS) is a systemic connective tissue disease, and abnormal connective tissue metabolism is implicated in inguinal hernias (IH). Associating XFS with comorbid conditions may illuminate their underlying pathophysiology and affect clinical screening and treatment. Exfoliation syndrome involves altered systemic extracellular matrix (ECM) homeostasis involving elastin metabolism. Hernias occur owing to abnormal ECM synthesis, metabolism, or repair. Inguinal hernias involve weakening or rupture of the abdominal/groin wall...
September 13, 2018: JAMA Ophthalmology
Gena M Damento, Nelson S Winkler, David O Hodge, Sunil S Khanna, Cheryl L Khanna
PURPOSE: To determine the effect of a glaucoma team care model on resource utilization and efficiency in glaucoma management. METHODS: Retrospective cohort study of 358 patients diagnosed and treated for glaucoma. Analysis included number of patient visits, diagnostic tests, and glaucoma procedures performed before (2005-2007) and after (2008-2010) implementation of a team care model in 2008. Patients not involved in the model served as controls. RESULTS: Number of patient visits did not change significantly after model implementation (p > ...
September 21, 2018: Seminars in Ophthalmology
Jordan Stanley, Carrie E Huisingh, Thomas A Swain, Gerald McGwin, Cynthia Owsley, Christopher A Girkin, Lindsay A Rhodes
PURPOSE: To determine the level of adherence to the American Academy of Ophthalmology (AAO) preferred practice pattern (PPP) guidelines for quality primary open angle glaucoma (POAG) and POAG suspect (POAGS) care among retail-based optometrists. METHODS: Patients with a diagnosis of POAG or POAGS who participated in a telemedicine pilot project were included. Patients' charts were evaluated for 15 elements of PPP guidelines for glaucoma care. Results were further stratified by number of follow-up visits and diagnosis...
September 18, 2018: Journal of Glaucoma
Jan Osmers, Michael Sorg, Andreas Fischer
Motivation Glaucoma is currently the most common irreversible cause of blindness worldwide. A significant risk factor is an individually increased intraocular pressure (IOP). A precise measurement method is needed to determine the IOP in order to support the diagnosis of the disease and to monitor the outcome of the IOP reduction as a medical intervention. A handheld device is under development with which the patient can perform self-measurements outside the clinical environment. Method For the measurement principle of the self-tonometer the eye is acoustically excited to oscillate, which is analyzed and attributed to the present IOP...
September 19, 2018: Biomedizinische Technik. Biomedical Engineering
Suresh Subramaniam, Jin Wook Jeoung, Won June Lee, Young Kook Kim, Ki Ho Park
PURPOSE: To compare the diagnostic capability of three-dimensional (3D) neuro-retinal rim thickness (NRR) with existing optic nerve head and retinal nerve fiber layer (RNFL) scan parameters using high-definition optical coherence tomography (HD-OCT). DESIGN: Retrospective study. METHODS: Based on the mean deviation (MD) of the Humphrey Field Analyzer (HFA), the 152 subjects were categorized into mild (MD > - 6 dB, 100), moderate (MD - 6 to - 12 dB, 26), and severe (MD < - 12 dB, 26) glaucoma...
September 18, 2018: Japanese Journal of Ophthalmology
Mieko Yanagisawa, Satoshi Kato, Makiko Ochiai
PURPOSE: To compare the Esterman Disability Score (EDS) obtained with Goldmann perimetry (GP) testing and the Humphrey field analyzer (HFA) in low vision Japanese subjects. Subjects were also divided into groups by diagnosis to examine how disease influences EDS measurements. METHODS: The EDS was obtained using GP (GP-EDS) and the built-in testing program of the HFA (HFA-EDS). Tests were performed within 3 months of each other. Regression analyses were used to examine the relationship between GP-EDS and HFA-EDS...
2018: PloS One
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