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cortisol biomarker

B Armstrong, S Buckingham-Howes, M M Black
OBJECTIVE: Low inhibitory control is linked with weight gain among youth. Inhibitory problems are associated with disruption to the hypothalamic-pituitary-adrenal axis cortisol response. Increased cortisol predicts appetite and weight gain (though may be gender specific). This study hypothesized that cortisol reactivity explains the association between inhibition and weight gain while considering the moderating factors of early stressors to the hypothalamic-pituitary-adrenal axis (e.g...
August 15, 2018: Pediatric Obesity
Janaina Silva Martins Humberto, Jefferson Veronezi Pavanin, Maria José Alves da Rocha, Ana Carolina Fragoso Motta
The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines...
August 13, 2018: Brazilian Oral Research
Kevin P Jensen, Gerald Valentine, Eugenia Buta, Elise E DeVito, Joel Gelernter, Mehmet Sofuoglu
Understanding the stimulatory effects of nicotine on cardiovascular function in humans is of great interest given the wide-spread use of different forms of combustible and smokeless products that deliver nicotine. An intravenous nicotine infusion procedure was used to evaluate factors associated with the acute heart rate (HR) response to nicotine (0.5 mg per 70 kg bodyweight) in a sample of 213 smokers. We tested for differential response to nicotine based on demographic characteristics (race [European American vs African America], sex, body mass index and age); a set of blood-based biomarkers (baseline nicotine, cotinine and cortisol levels and nicotine metabolite ratio); and a set of self-reported measures related to tobacco use...
August 11, 2018: Pharmacology, Biochemistry, and Behavior
Manja Bernsdorf, Lars Schwabe
Within the first 30-45 min after awakening, there is a characteristic rise in cortisol that is referred to as cortisol awakening response (CAR). Over the past decades, the CAR has become an important biomarker, mainly because of its reported association with health and disease. Previous research showed that the CAR can already be reliably assessed in infants and children. Yet, earlier findings on the influence of age have been inconsistent, and limited attention has been devoted to prepubertal children. Here, we aimed to contrast the magnitude and stability of the CAR in prepubertal children and adults...
August 13, 2018: Psychophysiology
Chrysoula-Christina Emmanouil, Panagiota Pervanidou, Evangelia Charmandari, Christina Darviri, George P Chrousos
OBJECTIVE: Our study aimed to evaluate the effectiveness of an 8-week stress management intervention program that included progressive muscle relaxation, diaphragmatic breathing, guided imagery, and cognitive restructuring in obese Greek children and adolescents. DESIGN: Thirty-six patients were prospectively recruited to participate in this randomized controlled study. Of these, 16 participants formed the intervention group and 20 participants the control group...
August 11, 2018: Hormones: International Journal of Endocrinology and Metabolism
Kheng Siang Ted Ng, Angelia Sia, Maxel K W Ng, Crystal T Y Tan, Hui Yu Chan, Chay Hoon Tan, Iris Rawtaer, Lei Feng, Rathi Mahendran, Anis Larbi, Ee Heok Kua, Roger C M Ho
The effect of horticultural therapy (HT) on immune and endocrine biomarkers remains largely unknown. We designed a waitlist-control randomized controlled trial to investigate the effectiveness of HT in improving mental well-being and modulating biomarker levels. A total of 59 older adults was recruited, with 29 randomly assigned to the HT intervention and 30 to the waitlist control group. The participants attended weekly intervention sessions for the first 3 months and monthly sessions for the subsequent 3 months...
August 9, 2018: International Journal of Environmental Research and Public Health
H K Knych, R M Arthur, D S McKemie, R Baden, N Oldberg, P H Kass
BACKGROUND: Flumethasone is a potent corticosteroid reportedly used in horses to decrease inflammation associated with strenuous exercise. There are currently no reports describing the use of this drug in horses. OBJECTIVES: To describe the pharmacokinetics and effects on cortisol and eicosanoid concentrations, following administration of flumethasone to exercised horses. STUDY DESIGN: Parallel design. METHODS: Twelve exercised horses received a single i...
August 6, 2018: Equine Veterinary Journal
Cosy Wing Ching Cheung, Alice Wong Wai Yee, Pui Shan Chan, Sotirios H Saravelos, Jacqueline Pui Wah Chung, Lai Ping Cheung, Grace Wing Shan Kong, Tin-Chiu Li
RESEARCH QUESTION: Does music therapy help in reducing pain and anxiety in women undergoing transvaginal ultrasound-guided oocyte retrieval (TUGOR)? DESIGN: In this randomized controlled open label study, 209 participants were recruited and randomized into three groups (music group, n = 70; headphone group, n = 70; control group, n = 69). Patients' psychological status was assessed using the visual analogue scale of pain (VAS-P), satisfaction of pain control, state-trait anxiety inventory (STAI), Beck depression inventory (BDI), and general health questionnaire (GHQ)...
August 2018: Reproductive Biomedicine Online
A K Putman, J L Brown, J C Gandy, L Wisnieski, L M Sordillo
Metabolic stress occurs in dairy cows when physiologic homeostasis is disrupted as a consequence of aberrant nutrient metabolism, chronic inflammation, and oxidative stress. Early-lactation cows that suffer from metabolic stress are susceptible to health disorders that cause significant production losses. However, there is little information regarding the occurrence and effect of metabolic stress during involution. Therefore, the purpose of this study was to investigate well-known biomarkers associated with metabolic stress in early-lactation cows at various time points during the early dry period when dairy cows also are subjected to dramatic changes in physiologic homeostasis...
August 1, 2018: Journal of Dairy Science
Marc J Weigensberg, Donna Spruijt-Metz, Cheng K Fred Wen, Jaimie N Davis, Quintilia Àvila, Magaly Juarez, Niquelle Brown Wadé, Christianne J Lane
Innovative lifestyle interventions are needed to reduce type 2 diabetes risk in adolescents. This report describes the protocol of the Imagine HEALTH cluster randomized control trial, that tests an intervention based in Self-Determination Theory (SDT) and uses lifestyle education combined with the mind-body, complementary health modality of guided imagery (GI), to address obesity prevention and treatment in predominantly Latino adolescents. The primary aim is to determine the unique effects of each of the three major components of the 12-week lifestyle intervention (lifestyle education, stress reduction guided imagery, and lifestyle behavior guided imagery) compared to control on primary outcomes of physical activity (accelerometry), dietary intake (3-day recall), and stress biomarker levels (salivary cortisol)...
August 1, 2018: Contemporary Clinical Trials
Robert A Huggins, Andrea R Fortunati, Ryan M Curtis, David P Looney, Chris A West, Elaine C Lee, Maren S Fragala, Mathew L Hall, Douglas J Casa
Huggins, RA, Fortunati, AR, Curtis, RM, Looney, DP, West, CA, Lee, EC, Fragala, MS, Hall, ML, and Casa, DJ. Monitoring blood biomarkers and training load throughout a collegiate soccer season. J Strength Cond Res XX(X): 000-000, 2018-This observational study aimed to characterize the responses of a comprehensive panel of biomarkers, observed ranges, training load (TL) metrics, and performance throughout the collegiate soccer season (August-November). Biomarkers (n = 92) were collected before the start of pre-season (PS), in-season weeks (W)1, W4, W8, and W12 in NCAA Division I male soccer players (n = 20, mean ± SD; age = 21 ± 1 years, height = 180 ± 6 cm, body mass = 78...
August 2, 2018: Journal of Strength and Conditioning Research
Rami M El Zein, Sheerazed Boulkroun, Fabio Luiz Fernandes-Rosa, Maria-Christina Zennaro
Aldosterone-producing adenomas (APA) are a major cause of primary aldosteronism (PA), the most common form of secondary hypertension. Exome analysis of APA has allowed the identification of recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 in more than 50 % of sporadic cases. These gain of function mutations in ion channels and pumps lead to increased and autonomous aldosterone production. In addition, somatic CTNNB1 mutations have also been identified in APA. The CTNNB1 mutations were also identified in cortisol-producing adenomas and adrenal cancer, but their role in APA development and the mechanisms specifying the hormonal production or the malignant phenotype remain unknown...
July 30, 2018: La Presse Médicale
Marlene P Freeman, Hang Lee, Gina M Savella, Alexandra Z Sosinsky, Samantha P Marfurt, Shannon K Murphy, Lee S Cohen
BACKGROUND: Despite high prevalence rates among women of mood disorders and of infertility, there is a paucity of systematic data to inform the treatment of women at risk for psychiatric morbidity in the context of assisted reproductive technologies (ART). The objective was to delineate predictors of depressive relapse in women with histories of mood disorders during ART, including the role of psychotropic medication continuation. METHODS: This was a prospective observational study of women undergoing ART with past diagnoses of major depressive disorder (MDD) or bipolar depression...
August 1, 2018: Journal of Women's Health
Oleg A Levada, Alexandra S Troyan
Poststroke depression (PSD) is the most prevalent psychiatric disorder after stroke, which is independently correlated with negative clinical outcome. The identification of specific biomarkers could help to increase the sensitivity of PSD diagnosis and elucidate its pathophysiological mechanisms. The aim of current study was to review and summarize literature exploring potential biomarkers for PSD diagnosis. The PubMed database was searched for papers published in English from October 1977 to December 2017, 90 of which met inclusion criteria for clinical studies related to PSD biomarkers...
2018: Frontiers in Neurology
Maik Pietzner, Kathrin Budde, Georg Homuth, Gabi Kastenmüller, Ann-Kristin Henning, Anna Artati, Jan Krumsiek, Henry Völzke, Jerzy Adamski, Markus M Lerch, Jens P Kühn, Matthias Nauck, Nele Friedrich
Background & Aims: Exaggerated hepatic triglyceride accumulation, i.e. hepatic steatosis, represents a strong risk factor for type 2 diabetes mellitus and cardiovascular disease. Despite a clear association of hepatic steatosis with impaired insulin signaling the precise molecular mechanisms involved are still under debate. We combined data from several metabolomics techniques to gain a comprehensive picture of molecular alterations related to the presence of hepatic steatosis in a diabetes-free sample (N=769) of the population-based Study of Health in Pomerania (SHIP)...
July 27, 2018: Journal of Clinical Endocrinology and Metabolism
Heloísa H A Barcellos, Gessi Koakoski, Fabiele Chaulet, Karina S Kirsten, Luiz C Kreutz, Allan V Kalueff, Leonardo J G Barcellos
Environmental enrichment is widely used to improve welfare and behavioral performance of animal species. It ensures housing of laboratory animals in environments with space and complexity that enable the expression of their normal behavioral repertoire. Auditory enrichment by exposure to classical music decreases abnormal behaviors and endocrine stress responses in humans, non-humans primates, and rodents. However, little is known about the role of auditory enrichment in laboratory zebrafish. Given the growing importance of zebrafish for neuroscience research, such studies become critical...
2018: PeerJ
Nadia Cattane, Cristina Mora, Nicola Lopizzo, Alessandra Borsini, Carlo Maj, Laura Pedrini, Roberta Rossi, Marco Andrea Riva, Carmine Maria Pariante, Annamaria Cattaneo
Epidemiological and clinical studies have provided evidence for a role of both genetic and environmental factors, such as stressful experiences early in life, in the pathogenesis of Schizophrenia (SZ) and microRNAs (miRNAs) have been suggested to play a key role in the interplay between the environment and our genome. In this study, we conducted a miRNOme analysis in different samples (blood of adult subjects exposed to childhood trauma, brain (hippocampus) of rats exposed to prenatal stress and human hippocampal progenitor cells treated with cortisol) and we identified miR-125b-1-3p as a down-regulated miRNA in all the three datasets...
July 26, 2018: Schizophrenia Research
Esin G Canli, Alper Dogan, Mustafa Canli
Nanoparticles (NPs) are used in diverse field of technology and consequently are released to the environment, most ending up in water bodies. Because NPs have potential to cause adverse effects on the metabolisms of animals, the present study was carried out to help understanding their effects on fish metabolism. In this study, freshwater fish (Oreochromis niloticus) were exposed to aluminum oxide (Al2 O3 ) (40 nm), copper oxide (CuO) (40 nm) and titanium dioxide (TiO2 ) (21 nm) NPs in differing concentrations (0, 1, 5, 25 mg/L) for 14 d...
September 2018: Environmental Toxicology and Pharmacology
Mustafa Metin Donma, Orkide Donma
Burn injury is a severe form of trauma associated with pain, metabolic abnormalities, susceptibility to infections, muscle loss, mental and emotional distress. Conventional therapies as well as some recent approaches for the treatment of burned patients are currently in use. Nutritional therapy is also suggested as a supplementary option in major burns. Within this context, hormones involved in the regulation of appetite will have a paramount importance. The aim is to evaluate the interactions among ghrelin, some inflammatory parameters and the burn injury...
September 2018: Medical Hypotheses
Richard S Lee, Pamela B Mahon, Peter P Zandi, Mary E McCaul, Xiaoju Yang, Utsav Bali, Gary S Wand
Chronic exposure to cortisol is associated with cardiovascular, metabolic, and psychiatric disorders. Although cortisol can be readily measured from peripheral sources such as blood, urine, or saliva, multiple samplings spanning several days to weeks are necessary to reliably assess chronic cortisol exposure levels (referred to as cortisol load). Although cortisol levels in hair have been proposed as a measure of cortisol load, measurement is cumbersome and many people are not candidates due to short hair length and use of hair dyes...
July 4, 2018: Psychoneuroendocrinology
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