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cortisol biomarker

Mohamed M Refaey, Dapeng Li
Transport procedures usually cause fish stress. The purpose of this study was to investigate the effect of transport stress on blood biochemical profiles, oxidative stress biomarkers, and hepatic heat shock proteins (HSPs) of channel catfish ( Ictalurus punctatus ). Fish (body weight 55.57 ± 5.13 g) were randomly distributed to two groups, the control, and the treatment. The control group was kept under the normal culture conditions. The treatment group was exposed to the process of transport (3.5 h). Fish samples were collected before transport, after packing and at 0, 1, 6, 24, 72, and 168 h after transport, respectively...
2018: Frontiers in Physiology
Javier Labad
For many years, the study of the psychotic phenotpe and approach to treatment of schizophrenia has been focused on positive psychotic symptoms, although the functional outcome is more clearly associated with negative and cognitive symptoms. Recently, there has been a growing interest in identifying biomarkers associated with these symptoms at early stages of the illness, including the risk of psychosis in vulnerable individuals (at-risk mental states [ARMS]). In this paper, the role of cortisol and prolactin in the clinical expression of psychosis will be reviewed...
November 22, 2018: Psychoneuroendocrinology
Ji Ho Lee, Yoon Ju Bae, So Hee Lee, Su Chin Kim, Hyun Young Lee, Ga Young Ban, Yoo Seob Shin, Hae Sim Park, Juergen Kratzsch, Young Min Ye
PURPOSE: Frequent changes in chronic urticaria (CU) activity over time can cause psychological stress, which also serves as a trigger of CU. To measure the control status of CU, the Urticaria Control Test (UCT) was developed in Germany. This study aimed to investigate the validity, reliability and responsiveness to changes in CU for the Korean version of the UCT (K-UCT) and its relation with salivary cortisol and cortisone levels. METHODS: Linguistic adaptation of the UCT into Korean was conducted...
January 2019: Allergy, Asthma & Immunology Research
R Vargas, J C Balasch, I Brandts, F Reyes-López, L Tort, M Teles
Environmental insults, such as exposure to pathogens, modulate the behavioural coping style of animals to stressors, and repeated exposure to stressful environments may lead to species-specific infection phenotypes. To analyse the influence of stress behavioural phenotypes on immune and metabolic performance, gilthead sea bream (Sparus aurata L.) were first screened for proactive and reactive coping styles. Once characterized, both behavioural phenotypes fish groups were bath vaccinated with bacterin from Vibrio anguillarum, an opportunistic widespread pathogen of fish...
November 26, 2018: Scientific Reports
Jung Soo Lim, Mi-Kyung Lee, Eunhee Choi, Namki Hong, Soo Il Jee, Sun Ho Kim, Eun Jig Lee
PURPOSE: The molecular mechanisms underlying tumor growth in Cushing's disease (CD) still remain a challenge. Moreover, clinical manifestations of CD may vary depending on hormonal activity; however, factors involved in the hormonal aggressiveness of adrenocorticotropic hormone (ACTH)-secreting pituitary tumors have not been fully clarified. We investigated the association between the expression of cellular markers regarding pituitary tumor progression and initial or postoperative hormone levels in patients with CD...
November 24, 2018: Endocrine
Giuseppe Angelo Zito, Kallia Apazoglou, Anisoara Paraschiv-Ionescu, Kamiar Aminian, Selma Aybek
BACKGROUND: Patients affected by functional (psychogenic) movement disorders (FMD) have abnormal processing of stress responses. However, little is known about the influence of this abnormal stress processing on automatic motor defense behavior, such as freeze response. Our aim was thus to investigate stress-induced postural motor responses in FMD. METHODS: Nine FMD patients and thirteen healthy controls were engaged in the Trier Social Stress Test, while we measured the movement of their body by means of accelerometers and gyroscopes attached to the thorax...
November 14, 2018: Psychoneuroendocrinology
César Agostinis-Sobrinho, Sonia Gómez-Martínez, Esther Nova, Aurora Hernandez, Idoia Labayen, Antonios Kafatos, Frederic Gottand, Dénes Molnár, Marika Ferrari, Luis A Moreno, Nathalie Michels, Azahara Ruperez, Jonatan R Ruiz, Ascensión Marcos
OBJECTIVE: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness and sleep with endocrine, metabolic and immunological health biomarkers in European adolescents. METHODS: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5 -17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors and sleep duration...
November 24, 2018: Pediatric Diabetes
Robert-Paul Juster, Marc Sasseville, Charles-Édouard Giguère, Signature Consortium, Sonia J Lupien
OBJECTIVE: Individuals requiring psychiatric emergency services are often highly distressed and intoxicated. To provide an objective and comprehensive measure of their stress-related physiological dysregulations, we indexed allostatic load with 14 biomarkers collected within 24 h of patients' admission to the largest psychiatric hospital in the Canadian province of Quebec. METHODS: This study (N = 278) combines data for emergency patients (n = 76; 65.8% women; M age = 44...
December 2018: Journal of Psychosomatic Research
Alejandro Morales-Jinez, Francisco J López-Rincón, Alicia Ugarte-Esquivel, Irma Andrade-Valles, Luz Elena Rodríguez-Mejía, José Luis Hernández-Torres
OBJECTIVE: to compare the biomarkers and the allostatic load levels in a sample of older persons with and without canine companionship. METHOD: descriptive and comparative study. Data were collected using a sociodemographic questionnaire and a fasting blood sample. The allostatic load comprised 11 biomarkers that are primary and secondary stress mediators, which arise from the following systems: neuroendocrine, immune, metabolic, cardiovascular and anthropometric...
November 14, 2018: Revista Latino-americana de Enfermagem
Nancy S Redeker, Samantha Conley, George Anderson, John Cline, Laura Andrews, Vahid Mohsenin, Daniel Jacoby, Sangchoon Jeon
BACKGROUND: Insomnia is common among patients with stable heart failure (HF) and associated with inflammation and altered autonomic function. PURPOSE: The purposes of this study were to examine the effects of cognitive behavioral therapy for insomnia (CBT-I) on the Hypothalamic Pituitary (HPA) Axis, autonomic function, inflammation, and circadian rhythmicity and the associations between these biomarkers and insomnia, sleep characteristics, symptoms, functional performance, and sleep-related cognitions...
November 21, 2018: Behavioral Sleep Medicine
Eric A Woodcock, Mark K Greenwald, Dalal Khatib, Vaibhav A Diwadkar, Jeffrey A Stanley
Working memory processes are associated with the dorsolateral prefrontal cortex (dlPFC). Prior research using proton functional magnetic resonance spectroscopy (1 H fMRS) observed significant dlPFC glutamate modulation during letter 2-back performance, indicative of working memory-driven increase in excitatory neural activity. Acute stress has been shown to impair working memory performance. Herein, we quantified dlPFC glutamate modulation during working memory under placebo (oral lactose) and acute stress conditions (oral yohimbine 54 mg + hydrocortisone 10 mg)...
November 17, 2018: NeuroImage
Maude Lambert, Marie-Ève Couture-Lalande, Kelly Brennan, Aldin Basic, Sophie Lebel, Catherine Bielajew
Introduction: One way to examine the extent to which the stress associated with a breast cancer experience (BC) impacts stress-related physiological mechanisms is to study the secretion patterns of associated biomarkers. Unlike cortisol and α-amylase (sAA), biomarkers of immune functioning such as secretory immunoglobulin A (SIgA) have rarely been examined in BC survivors. Aim of the study: This study had two principal aims: the first was to evaluate the basal secretion profiles of SIgA as well as its response to an acute stressor as a marker of immune health in BC survivors and women with no history of BC, and the second was to determine how SIgA stress-related patterns compare to published cortisol and sAA patterns in the same women...
2018: Contemporary Oncology Współczesna Onkologia
Ewa Jówko, Jerzy Sadowski, Barbara Długołęcka, Dariusz Gierczuk, Benedykt Opaszowski, Igor Cieśliński
Purpose: The objective of this study was to investigate the effects of chronic Rhodiola rosea ( R. rosea ) supplementation on mental and physical performance, as well as hormonal and oxidative stress biomarkers. Methods: Twenty-six healthy male students received either R. rosea extract (600 mg/day; RR) or placebo (PL) in a randomized double-blind trial. Prior to supplementation (Term I) and following 4 weeks of supplementation (Term II), the students underwent psychomotor tests for simple and choice reaction time, included in the Vienna Test System...
October 2018: Journal of Sport and Health Science
Blair T Crewther, Zbigniew Obmiński, Christian J Cook
Some equivocality exists regarding the effect of testosterone (T) on competitive performance with cortisol (C) implicated as a moderating factor. This study investigated whether C is moderating the T relationship with Olympic weightlifting (OWL) performance during real and simulated competitions. We monitored 105 male athletes (age 19.3±3.7 years); 46 during real OWL competitions (e.g., national age championships) and 59 across simulated events (e.g., talent identification). Serum T and C were assessed before warming up and within 15 minutes of event completion...
September 2018: Biology of Sport
Maor Zeev-Wolf, Jonathan Levy, Abraham Goldstein, Orna Zagoory-Sharon, Ruth Feldman
BACKGROUND: Early life stress (ELS) bears long-term negative consequences throughout life. Yet ELS effect is mostly unknown, and no study has followed children to test its impact on the default mode network (DMN) in relation to maternal behavior across childhood. Focusing on brain oscillations, we utilized a unique cohort of war-exposed preadolescent children (11-13 years of age) and their mothers followed from early childhood to examine the effects of ELS combined with observed parenting on DMN connectivity and power in mother and child...
October 3, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Kenia M B Carvalho, Débora B Ronca, Nathalie Michels, Inge Huybrechts, Magdalena Cuenca-Garcia, Ascensión Marcos, Dénes Molnár, Jean Dallongeville, Yannis Manios, Beatriz D Schaan, Luis Moreno, Stefaan de Henauw, Livia A Carvalho
Stress increases inflammation but whether adherence to Mediterranean diet counteracts this association and how early can these effects be observed is not well known. We tested whether (1) cortisol is associated to inflammation, (2) cortisol is associated to the adolescent Mediterranean diet score (aMDS), (3) aMDS lessens inflammation, (4) aMDS associates with cortisol levels and inflammation. Two hundred and forty-two adolescents (137 females; 12.5⁻17.5 years old) provided salivary cortisol, blood and 2-day 24-h dietary recall from which aMDS was derived...
November 15, 2018: Nutrients
Birthe R Dahlerup, Emilie L Egsmose, Volkert Siersma, Erik L Mortensen, Morten Hedegaard, Lisbeth E Knudsen, Line Mathiesen
BACKGROUND: Prenatal stress affects the health of the pregnant woman and the fetus. Cortisol blood levels are elevated in pregnancy, and fetal exposure to cortisol is regulated by the placenta enzyme 11β-HSD2. A decrease in enzyme activity allows more maternal cortisol to pass through the placental barrier. Combining the fetal and maternal cortisol to cortisone ratio into the adjusted fetal cortisol exposure (AFCE) represents the activity of the enzyme 11β-HSD2 in the placenta. AIM: To investigate the effect of prenatal maternal stress on the ratio of cortisol and cortisone in maternal and fetal blood at birth in a normal population...
2018: PloS One
Ya-Yun Xu, Jin-Fang Ge, Jun Liang, Yin Cao, Feng Shan, Yang Liu, Chun-Yu Yan, Qing-Rong Xia
Background: This study aimed to determine whether plasma nesfatin-1, cortisol, and inflammatory cytokines could be used as novel noninvasive biomarkers for the diagnosis of moderate and severe depressive disorder (MSDD). Materials and methods: A total of 70 patients with MSDD and 70 healthy subjects were assessed. Patients with MSDD were selected from Hefei Fourth People's Hospital, Anhui Mental Health Center, and subjects in the control group were selected from healthy volunteers...
2018: Psychology Research and Behavior Management
Yi Wang, Naomi Fujioka, Chengguo Xing
Aim, materials & methods: Urinary cortisol profile has the potential as a diagnostic biomarker. We therefore developed a stable-isotope dilution ultraperformance chromatography multistage MS-based method to quantify cortisol and 16 metabolites in human urines. Results & conclusion: The LOD for cortisol and its metabolites ranges from 0.02 to 5.81 pg/μl urine. The inter- and intraday variations were 3.7-12.9% and 3.5-15.6%, respectively. Among the metabolites analyzed, significant person-to-person heterogeneity was observed, demonstrating the need for comprehensive metabolite profiling in diagnosis...
November 6, 2018: Bioanalysis
Yoon Ju Bae, Janis Reinelt, Jeffrey Netto, Marie Uhlig, Anja Willenberg, Uta Ceglarek, Arno Villringer, Joachim Thiery, Michael Gaebler, Juergen Kratzsch
BACKGROUND: Stress activates the central nervous, the autonomic nervous, and the endocrine system. This study aimed to (1) test the usability of salivary cortisone in a standardized psychosocial stressor, (2) create a comprehensive profile of hormonal responses to determine laboratory parameters with high discriminatory power, and (3) analyze their association with psychometric and autonomic stress measures. METHODS: Healthy young men (18-35 years) completed either the Trier Social Stress Test (TSST) (n = 33) or a Placebo-TSST (n = 34)...
October 28, 2018: Psychoneuroendocrinology
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