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cortisol biomarker

Mauricio Castro-Sepulveda, Rodrigo Ramirez-Campillo, Felipe Abad-Colil, Camila Monje, Luis Peñailillo, Jorge Cancino, Hermann Zbinden-Foncea
A soccer match induce changes in physiological stress biomarkers as testosterone (T), cortisol (C), and testosterone:cortisol (T:C) ration. Hydration state may also modulate these hormones, and therefore may alter the anabolic/catabolic balance in response to soccer match. The role of hydration status before the match in this biomarkers has not yet been reported. The aim of this study was to compare the salivary T, C, and the T:C ratio responses after two friendly matches in well-hydrated and mild-dehydrated (MD) elite young male soccer player...
2018: Frontiers in Physiology
Antje Bullack, Carolin Gass, Urs M Nater, Gunter Kreutz
Previous studies have suggested that there are complex psychobiological effects of amateur choral singing on well-being. Here, we investigate the influences of singing vs. non-singing on psychological and biological measurements, reflecting current positive and negative affect, perceived social connectedness, and physiological stress. We hypothesized that active singing leads to significant increases in these measurements compared to participating without singing. Amateur choristers (Exp. 1: N = 54, age range 18-85 years and Exp...
2018: Frontiers in Behavioral Neuroscience
Sebastian Laufer, Sinha Engel, Christine Knaevelsrud, Sarah Schumacher
Dysregulations of the hypothalamus-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS) as parts of the stress response system have been associated with development and maintenance of various mental disorders. It has been suggested that these alterations might normalize in the course of psychotherapy. We conducted a comprehensive review of psychotherapeutic intervention effects on HPA axis and ANS regulation in adult samples with mental disorders. We searched four databases for psychotherapeutic intervention studies with mentally ill patient samples, assessing cortisol and/or α-amylase before and after treatment...
October 11, 2018: Neuroscience and Biobehavioral Reviews
Sivakami Rethnam Haug, Mihaela Cuida Marthinussen
AIMS: To investigate whether acute dental pain due to pulpal or periapical inflammation is associated with increased expression of cortisol and inflammatory markers and mediators in the saliva, as well as changes in salivary flow rate. METHODS: Patients experiencing pain (n = 42) were recruited when seeking emergency dental treatment. A 0 to 10 numeric rating scale (NRS) was used as a measure of the severity of pain, and the number of days with pain sensation was also recorded...
October 10, 2018: Journal of Oral & Facial Pain and Headache
Tze Pin Ng, Yanxia Lu, Robin Wai Mun Choo, Crystal Tze Ying Tan, Ma Shwe Z Nyunt, Qi Gao, Esther Wing Hei Mok, Anis Larbi
Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia. We used 40 blood biomarkers belonging to community-dwelling prefrail and frail older persons to derive measures of multiple physiological pathways, and structural equation modeling to generate path network models of the multisystem physiological dysregulations associated with muscle mass and function (MMF)...
October 9, 2018: Aging Cell
S Fischer, S King, A Papadopoulos, M Hotopf, A H Young, A J Cleare
OBJECTIVE: Around 30-50% of patients with depression and anxiety disorders fail to respond to standard psychological therapy. Given that cortisol affects cognition, patients with altered hypothalamic-pituitary-adrenal (HPA) axis functioning may benefit less from such treatments. To investigate this, reliable pretreatment cortisol measures are needed. METHOD: N = 89 outpatients with depression and anxiety disorders were recruited before undergoing therapy within an Improving Access to Psychological Therapies (IAPT) service...
October 9, 2018: Acta Psychiatrica Scandinavica
Harald Murck, Matthias C Braunisch, Carsten Konrad, Daniela Jezova, Tilo Kircher
The renin-angiotensin-aldosterone system and its hormone receptors, i.e. the angiotensin and mineralocorticoid receptor (MR), have emerged as important targets for central nervous system disorders and in particular for major depression. We have recently characterized baseline MR function as a predictor for treatment outcome with standard antidepressants. The aims of this study are (i) to characterize how strongly an early biomarker change (after 2 weeks) is related to outcome and (ii) whether these biomarker changes are related to the final outcome, that is, could serve as surrogate markers for response...
October 8, 2018: International Clinical Psychopharmacology
Martina Zangheri, Mara Mirasoli, Massimo Guardigli, Fabio Di Nardo, Laura Anfossi, Claudio Baggiani, Patrizia Simoni, Mario Benassai, Aldo Roda
During space missions, real-time monitoring of astronauts' health status is of crucial importance and therefore there is a strong demand for simple analytical devices that astronauts can use to perform clinical chemistry analyses directly onboard. As part of the "IN SITU Bioanalysis" project, we designed a biosensor for analysing salivary levels of cortisol in astronauts, a marker of chronic stress. The biosensor is based on the Lateral Flow Immunoassay (LFIA) approach coupled with chemiluminescence (CL) detection and comprises a 3D-printed plastic cartridge containing a sealed fluidic element with the LFIA strip, in which the flow of sample and reagents is activated by pressing buttons on the cartridge and sustained by exploiting capillary forces...
September 17, 2018: Biosensors & Bioelectronics
Dina M Metwally, Ebtesam M Al-Olayan, Reem A Alshalhoop, Shatha A Eisa
This study was designed to investigate the use of specific biomarkers, such as albumin, serum total protein, aspartate amino transferase (AST), globulin, alanine amino transferase (ALT), serum cortisol and alkaline phosphatase (ALP), as predictive tools for sarcoptic mange in rabbits. A total of 30 infested rabbits were equally divided into three treatment groups. Each group was administered either propolis, ivermectin, or propolis with ivermectin. Treated rabbit results were then compared to those of 10 infested untreated rabbits and 10 healthy rabbits...
October 5, 2018: Bioscience Reports
Corina Aguilar-Raab, Marc N Jarczok, Marco Warth, Martin Stoffel, Friederike Winter, Maria Tieck, Judith Berg, Lobsang Tenzin Negi, Tim Harrison, Thaddeus W W Pace, Beate Ditzen
INTRODUCTION: Positive social interactions (PSIs) and stable relationships can exert substantial benefits on health. However, patients suffering from depression benefit less from these health-promoting effects. Moreover, relationship quality and even partners' health has been found to be negatively affected by depressive symptomatology, which may result in overall impairments in social functioning of a romantic couple. Psychobiological research indicates that these impairments may be accompanied by a maladaptive regulation of the patient's neuroendocrine response to external stressors...
October 4, 2018: BMJ Open
Sana Ullah, Zhongqiu Li, Muhammad Zain Ul Arifeen, Shahid Ullah Khan, Shah Fahad
Deltamethrin (DLM) is α-cyano (type II) synthetic pyrethroid. DLM exposure leads to strong neurotoxic effects and a number of complex toxicological syndromes. The current study assessed DLM mediated oxidative stress, behavioral, hematological, histopathological, and biochemical toxic effects on silver carp (Hypophthalmichthys molitrix). Exposure to an acute concentration (2 μg/L) of DLM resulted in different behavioral inconsistencies and a time-dependent significant (P < 0.05) change in the hematology and serum biochemistry of silver carp...
September 25, 2018: Chemosphere
Stephanie Deighton, Alexandra Neville, Dennis Pusch, Keith Dobson
Adverse Childhood Experiences (ACEs) are stressful and/or traumatic experiences that occur during childhood. Research has demonstrated a link between ACEs and risk of physical and mental health disorders, where early life adversity may become "biologically embedded" and have wide-ranging effects on various physiological systems. The aim of this study was to identify the extent and breadth of recent research activity relating to biological measures of ACEs in adulthood. We undertook a scoping review including published research articles...
August 25, 2018: Psychiatry Research
Andrew J Steckl, Prajokta Ray
Hormones produced by glands in the endocrine system and neurotransmitters produced by the nervous system control many bodily functions. The concentrations of these molecules in the body are an indication of its state, hence the use of the term biomarker. Excess concentrations of biomarkers, such as cortisol, serotonin, epinephrine, dopamine, are released by the body in response to a variety of conditions - emotional state (euphoria, stress), disease, etc. The development of simple, low-cost modalities for point-of-use (PoU) measurements of biomarkers levels in various bodily fluids (blood, urine, sweat, saliva) as opposed to conventional hospital or lab settings is receiving increasing attention...
September 28, 2018: ACS Sensors
Despoina Tzira, Anargyroula Prezerakou, Ioannis Papadatos, Artemis Vintila, Anastasia Bartzeliotou, Filia Apostolakou, Ioannis Papassotiriou, Vassiliki Papaevangelou
Objective: Measurement of salivary biomarkers can provide important information regarding hypothalamic-pituitary-adrenal axis activity both under normal conditions as well as in response to psychological or physical stress. Our aim was to correlate salivary stress markers, such as cortisol, α-amylase and immunoglobulin A, with the Pediatric Risk Index Score of Mortality, underlying disease (pathologic, trauma and postoperative), need for mechanical ventilation/sedation and time lag between onset of illness and admission in children admitted in the pediatric intensive care unit...
2018: SAGE Open Medicine
Neeraj Kumar, Narendra Pratap Singh
The present investigation aims to study role of dietary selenium (Se) on growth performance, oxidative stress markers (catalase, superoxide dismutase and glutathione-s-transferase), stress biomarkers [blood glucose, cortisol and heat shock protein (HSP 70) and immunological status, Nitro blue tetrazolium (NBT), total protein, albumin, globulin, A/G ratio, total immunoglobulin and vitamin C] and survival of fish after Aeromonas veronii biovar sobria challenged. Pangasianodon hypophthalmus was treated with lead (Pb, 4 ppm), and high temperature (34 °C) for 60 days...
September 24, 2018: Fish & Shellfish Immunology
Michael J E Greff, Jeffrey M Levine, Awatif M Abuzgaia, Abdelbaset A Elzagallaai, Michael J Rieder, Stan H M van Uum
BACKGROUND: Hair cortisol analysis is increasingly being appreciated and applied in both research and medicine, aiding endocrinologists with diagnosis. CONTENT: We provide an overview of hair cortisol research in general and an update on methodological considerations including the incorporation of cortisol into hair, hair growth rates, and sampling procedures, mincing vs. grinding of samples during preparation for extraction, various extraction protocols, and quantification techniques...
September 24, 2018: Clinical Biochemistry
Tanuj Dada, Deepti Mittal, Kuldeep Mohanty, Muneeb A Faiq, Muzaffer A Bhat, Raj K Yadav, Ramanjit Sihota, Talvir Sidhu, Thirumurthy Velpandian, Mani Kalaivani, Ravindra M Pandey, Ying Gao, Bernhard A Sabel, Rima Dada
BACKGROUND: Reducing intraocular pressure (IOP) in primary open angle glaucoma (POAG) is currently the only approach to prevent further optic nerve head damage. However, other mechanisms such as ischemia, oxidative stress, glutamate excitotoxicity, neurotrophin loss, inflammation/glial activation, and vascular dysregulation are not addressed. Because stress is a key risk factor affecting these mechanisms, we evaluated if mindfulness based stress reduction (MBSR) can lower IOP and normalize typical stress biomarkers...
September 25, 2018: Journal of Glaucoma
Klara Coello, Klaus Munkholm, Flemming Nielsen, Maj Vinberg, Lars Vedel Kessing
OBJECTIVE: Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with BD. METHOD: In a cross-sectional design, we compared hair cortisol concentrations in 181 patients with newly diagnosed/first episode BD, 42 of their unaffected first-degree relatives and 101 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder...
September 17, 2018: Psychoneuroendocrinology
Anuj Singh, Muneendra Kumar, Vinod Kumar, Debashis Roy, Raju Kushwaha, Shalini Vaswani, Avinash Kumar
Nickel (Ni) has not been elucidated as an essential mineral in dairy animals, though in plants and lower organisms, its role in activation of urease enzyme is well known. This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status, and energy and lipid metabolism in growing cattle. Eighteen growing Hariana heifers were randomly allocated into three groups on body weight (125 ± 3.0 kg) and age basis (10 ± 2.0 months)...
September 20, 2018: Biological Trace Element Research
Stanford E Mwasongwe, Bessie Young, Aurelian Bidulescu, Mario Sims, Adolfo Correa, Solomon K Musani
BACKGROUND: Few investigations have evaluated the incremental usefulness of multiple biomarkers representing varying physiological pathways for predicting risk of renal outcomes in African Americans. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We related a multi-marker panel to incident chronic kidney disease (CKD) and rapid kidney function decline (RKFD) in 2813 Jackson Heart Study participants without prevalent CKD at exam 1 (2000-2004) and with complete assays at exam 1 for 9 biomarkers: adiponectin, aldosterone, B-natriuretic peptide [BNP], cortisol, high sensitivity C-reactive protein (hsCRP), endothelin, homocysteine, plasma renin activity and mass...
September 20, 2018: BMC Nephrology
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