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movement diseases

Eva Z Reininghaus, Lisa-Christin Wetzlmair, Frederike T Fellendorf, Martina Platzer, Robert Queissner, Armin Birner, Ren Pilz, Carlo Hamm, Alexander Maget, Alexandra Rieger, Antonia Prettenhofer, Walter Wurm, Sabrina Mörkl, Nina Dalkner
The importance of the microbiome for psychological well-being has gained rising interest in the last decade. A strategy to examine the role of the microbiome in different diseases is the intake of supplements that modulate the gut microbiome. Despite promising results in animal studies, research in humans is sparse to date and especially in individuals with psychiatric disorders almost missing. The current report of the ProbioBIP-one pilot study aims at describing general effects of the intake of the probiotic OMNi-BiOTiC Stress repair® on psychological parameters as well as gastrointestinal symptoms and general compliance in a cohort of euthymic individuals with bipolar disorder (BD), receiving daily probiotic treatment over a time period of 3 months...
October 19, 2018: Neuropsychobiology
Daniela Pohl, Anastasia Alpous, Sabrina Hamer, Patricia E Longmuir
OBJECTIVE: The objective of this study was to determine the physical literacy (the motivation, confidence, physical competence, and knowledge contributing to the capacity for physical activity) of children with epilepsy, as compared with that of their healthy peers. METHODS: Patients age 8-12 years with epilepsy, without any disabilities interfering with their ability to answer questionnaires and perform vigorous physical activity, were recruited from the Neurology Clinic at the time of visits...
October 18, 2018: Epilepsy & Behavior: E&B
R Prashanth, Sumantra Dutta Roy
Early detection of Parkinson's disease (PD) is important which can enable early initiation of therapeutic interventions and management strategies. However, methods for early detection still remain an unmet clinical need in PD. In this study, we use the Patient Questionnaire (PQ) portion from the widely used Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) to develop prediction models that can classify early PD from healthy normal using machine learning techniques that are becoming popular in biomedicine: logistic regression, random forests, boosted trees and support vector machine (SVM)...
November 2018: International Journal of Medical Informatics
Helen Dallosso, Tom Yates, Hamidreza Mani, Laura J Gray, Nafeesa Dhalwani, Emma Baldry, Clare Gillies, Sue Cradock, Mark Batt, Melanie J Davies, Kamlesh Khunti
BACKGROUND: Multimorbidity, defined as two or more concurrent chronic diseases within the same individual, is becoming the clinical norm within primary care. Given the burden of multimorbidity on individuals, carers and health care systems, there is a need for effective self-management programmes. Promoting active participation within their clinical care and following a healthy lifestyle will help empower patients and target lifestyle factors that are exacerbating their conditions. The aim of this study is to establish whether a tailored, structured self-management programme can improve levels of physical activity at 12 months, in people with multimorbidity...
October 20, 2018: Trials
Ben Sidaway, Aimee Aaroe, D Monique Albert, Kristen Brasier, Garrett Desrosiers, Megan Keith, Alexandra Laniewski, Jaime Knowles, Caryce Morell, Jason Prada, Jessica Stuart, Rachel Voicechovski
BACKGROUND: An essential requirement for the guidance of action in cluttered environments is that people can accurately perceive what actions are afforded by particular surroundings given the person's action capabilities. Research has shown that healthy young individuals turn their shoulders when walking through a doorway when the aperture is less than a certain percentage of their shoulder width and that they are able to detect this critical width with visual inspection. These findings imply that movements are constrained by perception of the environment in body-scaled units...
October 17, 2018: Neuropsychologia
D Latz, E Schiffner, J Schneppendahl, B H Thalmann, P Jungbluth, J Grassmann, J Windolf, S V Gehrmann
OBJECTIVE: Driving a motor vehicle is one of the most important aspects of personal mobility in our society. However, there is a lack of evidence regarding driving fitness after orthopedic or trauma surgery-related diseases. Aim of this systematic review was to support the treating physician to determine the individual driving fitness in patients with musculosceletal disorders. MATERIAL AND METHODS: A systematic analysis was performed using the PubMed database...
October 19, 2018: Der Unfallchirurg
Naoto Soya, Ariel Roldan, Gergely L Lukacs
Cystic fibrosis (CF) is one of the most common, lethal autosomal recessive diseases in Caucasians with a life expectancy of 37-47 years. The CF transmembrane conductance regulator (CFTR) is a plasma membrane ion channel, confined to apical membrane of epithelia, and ensures transepithelial water and solute movement across secretory epithelia in several organs. Numerous CF mutations, including the most prevalent deletion of F508 (ΔF508) in the nucleotide binding domain 1 (NBD1) leads to CFTR global misfolding and premature intracellular degradation at the endoplasmic reticulum (ER)...
2019: Methods in Molecular Biology
Yu Seby Chen, Guennadi Kozlov, Rayan Fakih, Yosuke Funato, Hiroaki Miki, Kalle Gehring
Proteins of the family of CBS domain divalent metal cation transport mediators (CNNMs, also called ancient conserved domain proteins, ACDPs) are represented by four integral membrane proteins that have been proposed to function as Mg2+ transporters. CNNMs are associated with a number of genetic diseases affecting ion movement and cancer via their association with highly oncogenic phosphatases of regenerating liver (PRL). Structurally, CNNMs contain an N-terminal extracellular domain, a transmembrane domain (DUF21), and a large cytosolic region containing a cystathionine-β-synthase (CBS) domain and a putative cyclic nucleotide-binding homology (CNBH) domain...
October 19, 2018: Journal of Biological Chemistry
Manfred S Green, James LeDuc, Daniel Cohen, David R Franz
Global terrorism is a rapidly growing threat to world security, and increases the risk of bioterrorism. In this Review, we discuss the potential threat of bioterrorism, agents that could be exploited, and recent developments in technologies and policy for detecting and controlling epidemics that have been initiated intentionally. The local and international response to infectious disease epidemics, such as the severe acute respiratory syndrome and west African Ebola virus epidemic, revealed serious shortcomings which bioterrorists might exploit when intentionally initiating an epidemic...
October 16, 2018: Lancet Infectious Diseases
Ming Cao, Yuan Li, ZhuQin Gu, TaoMian Mi, XiTong Xu, CuiHong Ma, MeiJie Chen, MengMeng Wu, Piu Chan
INTRODUCTION: Hyposmia is a common non-motor symptom occurring in Parkinson's disease (PD), and has been included in the diagnostic criteria. Although a version of the Brief Smell Identification Test (B-SIT) has been developed specifically for Chinese populations, there have been no reports of the utility of this test in the diagnosis of PD in China. OBJECTIVE: Considering the influence of cultural factors on olfactory test findings, we sought to investigate the utility and efficiency of the B-SIT in Chinese PD patients...
October 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Claudia Ferraris, Roberto Nerino, Antonio Chimienti, Giuseppe Pettiti, Nicola Cau, Veronica Cimolin, Corrado Azzaro, Giovanni Albani, Lorenzo Priano, Alessandro Mauro
A home-based, reliable, objective and automated assessment of motor performance of patients affected by Parkinson's Disease (PD) is important in disease management, both to monitor therapy efficacy and to reduce costs and discomforts. In this context, we have developed a self-managed system for the automated assessment of the PD upper limb motor tasks as specified by the Unified Parkinson's Disease Rating Scale (UPDRS). The system is built around a Human Computer Interface (HCI) based on an optical RGB-Depth device and a replicable software...
October 18, 2018: Sensors
Marco Marklewitz, Sandra Junglen
The emergence of arthropod-borne viruses (arboviruses) is of global concern as they can rapidly spread across countries and to new continents as the recent examples of chikungunya virus and Zika virus have demonstrated. Whereas the global movement patterns of emerging arboviruses are comparatively well studied, there is little knowledge on initial emergence processes that enable sylvatic (enzootic) viruses to leave their natural amplification cycle and infect humans or livestock, often also involving infection of anthropophilic vector species...
October 16, 2018: Acta Tropica
Julien F Bally, Aurélie Méneret, Emmanuel Roze, Melanie Anderson, David Grabli, Anthony E Lang
Whipple's disease, affecting the CNS, can cause a wide variety of symptoms. Movement disorders are very prevalent, and some are pathognomonic of the disease. This systematic review analyzed all published cases of movement disorders because of CNS Whipple's disease, providing detailed information on clinical and associated features. We have also attempted to address sources of confusion in the literature, particularly related to differing uses of the terminology of movement disorder. This comprehensive overview of Whipple's disease-induced movement disorders aims to aid neurologists in recognizing this very rare disorder and successfully reaching a laboratory-confirmed diagnosis in order to initiate appropriate therapy...
October 19, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Deepa Dash, Sanjay Pandey
Movement disorders are one of the common clinical feature of neurological disease associated with neuronal antibodies. which is a group of potentially reversible disorder. They can present with hypokinetic or hyperkinetic types of involuntary movements and may have other associated neurological symptoms. The spectrum of abnormal movements associated with neuronal antibodies is widening. Some specific phenomenology of movement disorders are likely to give clue about the type of antibody, for instance presence of paroxysmal dystonia (facio-brachial dystonic seizures) are a pointer towards presence of LGI-1 antibodies, and orofacial lingual dyskinesia is associated with NMDAR associated encephalitis...
October 18, 2018: Acta Neurologica Scandinavica
Bin Wu, Ting Xu, Youping Li, Xi Yin
BACKGROUND: Familial Mediterranean fever, a hereditary auto-inflammatory disease, mainly affects ethnic groups living in the Mediterranean region. Early studies reported colchicine as a potential drug for preventing attacks of familial Mediterranean fever. For those people who are colchicine-resistant or intolerant, drugs such as rilonacept, anakinra, canakinumab, etanercept, infliximab, thalidomide and interferon-alpha might be beneficial. This is an updated version of the review. OBJECTIVES: To evaluate the efficacy and safety of interventions for reducing inflammation in people with familial Mediterranean fever...
October 19, 2018: Cochrane Database of Systematic Reviews
Julian Merz, Philipp Albrecht, Sunaina von Garlen, Ibrahim Ahmed, Daniel Dimanski, Dennis Wolf, Ingo Hilgendorf, Carmen Härdtner, Katja Grotius, Florian Willecke, Timo Heidt, Heiko Bugger, Natalie Hoppe, Ulrich Kintscher, Constantin von Zur Mühlen, Marco Idzko, Christoph Bode, Andreas Zirlik, Peter Stachon
Sterile inflammation of visceral fat, provoked by dying adipocytes, links the metabolic syndrome to cardiovascular disease. Danger-associated molecular patterns, such as adenosine triphosphate (ATP), are released by activated or dying cells and orchestrate leukocyte infiltration and inflammation via the purinergic receptor P2Y2 . The gene expression of ATP receptor P2Y2 did not change in several tissues in the course of obesity, but was increased within epididymal fat. Adipose tissue from P2Y 2 -/- mice consuming high-fat diet (HFD) contained less crown-like structures with a reduced frequency of adipose tissue macrophages (ATMs)...
October 18, 2018: Basic Research in Cardiology
Boyu Gu, Xiaolin Wang, Michael D Twa, Johnny Tam, Christopher A Girkin, Yuhua Zhang
The flow of erythrocytes in parafoveal capillaries was imaged in the living human eye with an adaptive optics near-confocal ophthalmoscope at a frame rate of 800 Hz with a low coherence near-infrared (NIR) light source. Spatiotemporal traces of the erythrocyte movement were extracted from consecutive images. Erythrocyte velocity was measured using custom software based on the Radon transform. The impact of imaging speed on velocity measurement was estimated using images of frame rates of 200, 400, and 800 Hz...
August 1, 2018: Biomedical Optics Express
Maowen Ba, Guoping Yu, Min Kong, Hui Liang, Ling Yu
Background: Rapid eye movement sleep behavior disorder (RBD) is associated with cognitive decline in early Parkinson's disease (PD). However, the underlyling basis for this association remains unclear. Methods: Parkinson's Progression Marker's Initiative (PPMI) subjects underwent baseline RBD testing with RBD sleep questionnaire (RBDSQ). Serial assessments included measures of motor symptoms, non-motor symptoms (NMS), neuropsychological assessment, blood and cerebrospinal fluid (CSF) biomarkers...
2018: Translational Neurodegeneration
Christel Leyronas, Cindy E Morris, Maria Choufany, Samuel Soubeyrand
Many phytopathogenic fungi are disseminated as spores via the atmosphere from short to long distances. The distance of dissemination determines the extent to which plant diseases can spread and novel genotypes of pathogens can invade new territories. Predictive tools including models that forecast the arrival of spores in areas where susceptible crops are grown can help to more efficiently manage crop health. However, such models are difficult to establish for fungi with broad host ranges because sources of inoculum cannot be readily identified...
2018: Frontiers in Microbiology
Filippo Manti, Francesca Nardecchia, Sabina Barresi, Martina Venditti, Simone Pizzi, Fadi F Hamdan, Nenad Blau, Alberto Burlina, Marco Tartaglia, Vincenzo Leuzzi
INTRODUCTION: Clathrins play a key role in endocytosis, recycling, and trafficking as well as the generation of presynaptic vesicles. We report a new clinical condition associated with a de novo variant in the CLTC gene, which encodes the clathrin heavy polypeptide. CASE REPORT: This 30-year-old woman presented with a developmental disorder during childhood that progressed to mild cognitive decline in late childhood and relapsing-remitting hypokinetic-rigid syndrome with severe achalasia, weight loss, and mood disorder in adulthood...
October 11, 2018: Parkinsonism & related Disorders
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