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movement diseases

Catalina Salgado-Salazar, Nina Shiskoff, Margery Daughtrey, Cristi L Palmer, Jo Anne Crouch
Peronospora sparsa is a downy mildew-causing oomycete that can infect roses, blackberries, and other members of the rose family. During the last 70 years, this disease has become a serious problem for rose growers in the U.S. and worldwide. While much is known about the disease and its treatment, including significant research on molecular identification methods, as well as environmental conditions conducive to disease and the fungicides used to prevent it, significant knowledge gaps remain in our basic comprehension of the pathogen's biology...
August 15, 2018: Plant Disease
Joy Lynn Tan, Thushara Perera, Jennifer L McGinley, Shivanthan Arthur Curtis Yohanandan, Peter Brown, Wesley Thevathasan
Postural reflexes are impaired in conditions such as Parkinson's disease, leading to difficulty walking and falls. In clinical practice, postural responses are assessed using the 'pull test', where an examiner tugs the pre-warned, standing patient backwards at the shoulders and grades the response. However, validity of the pull test is debated with issues including scaling and variability in administration and interpretation. It is unclear whether to assess the first trial or only subsequent repeated trials...
August 15, 2018: Journal of Neurophysiology
Chung-Wah Cheng, Li Zhang, Chen Zhao, Linda Ld Zhong, Li-Jie Shi, Liang Dai, Rui Zheng, Jing Chen, Ge Li, Jing-Bo Zhai, Wai Kun, Ai-Ping Lu, Hong-Cai Shang, Zhao-Xiang Bian
BACKGROUND: Syndrome is one of the most important concepts in Chinese medicine (CM) theory. However, it was not well accounted in most of randomized controlled trials (RCTs). OBJECTIVE: To determine whether CM syndrome differentiation affects the treatment results, functional constipation (FC) was selected as a target disease, and MaZiRenWan (, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. METHODS: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up...
August 14, 2018: Chinese Journal of Integrative Medicine
Mark Edward Packer
Movement disorders encompass a wide range of medical conditions that demonstrate changes to muscle function and tone which present with orofacial dyskinesia and dystonia. The most common conditions exhibiting these features are Parkinson's disease, Down syndrome, chorea and epilepsy. AIM: To establish whether implant success in patients suffering from movement disorders is similar to the general population, identifying risk factors and noting recommendations that may aid maintenance programmes...
2018: European Journal of Oral Implantology
Amritha Gourisankar, Sarah A Eisenstein, Nicholas T Trapp, Jonathan M Koller, Meghan C Campbell, Mwiza Ushe, Joel S Perlmutter, Tamara Hershey, Kevin J Black
The anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) contributes to the variability of motor and non-motor responses across patients with Parkinson's disease (PD). We previously tested the hypothesis using a three-dimensional (3D) statistical method to interpret the acute effects of unilateral DBS at each patient's clinically optimized DBS settings and active contact...
July 2018: Royal Society Open Science
Li Lu, Anantha Marisetty, Bin Liu, Mohamed Mostafa Kamal, Joy Gumin, Bethany Veo, YouQing Cai, Dina Hamada Kassem, Connie Weng, Mark E Maynard, Kimberly N Hood, Gregory N Fuller, Zhizhong Z Pan, Matthew D Cykowski, Pramod K Dash, Sadhan Majumder
Overexpression of REST has been implicated in brain tumors, ischemic insults, epilepsy, and movement disorders such as Huntington's disease. However, owing to the lack of a conditional REST overexpression animal model, the mechanism of action of REST overexpression in these disorders has not been established in vivo. We created a REST overexpression mouse model using the human REST (hREST) gene. Our results using these mice confirm that hREST expression parallels endogenous REST expression in embryonic mouse brains...
August 14, 2018: Scientific Reports
Saskia Bolz, Andreas Totzeck, Kerstin Amann, Mark Stettner, Christoph Kleinschnitz, Tim Hagenacker
BACKGROUND: We present a patient fulfilling the electrophysiological criteria for definite chronic inflammatory demyelinating polyneuropathy (CIDP), antibody-positive myasthenia gravis (MG), and membranous glomerulonephritis (MGN) confirmed by biopsy. To our knowledge, this is the first case of the concomitant appearance of these three autoimmune diseases in a single patient. CASE REPRESENTATION: A 42-year-old Caucasian male presented with rapidly progressive gait disturbance, distal weakness of the lower extremities, ascending hypoesthesia, impaired fine motor skills, and beginning cranial nerve palsy showing dysarthrophonia, facial paralysis, and eye movement abnormalities and was diagnosed as rapid onset (atypical) CIDP...
August 14, 2018: BMC Neurology
Y P Liu, Y H Li, W B Ma
No abstract text is available yet for this article.
August 7, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Patrick D Mathews, Omar Mertins, José O L Pereira, Antonio A M Maia, Edson A Adriano
Myxosporean are endoparasitic cnidarians of wide distribution and responsible for important economic losses in fisheries and aquaculture. A new myxosporean species, Henneguya peruviensis n. sp., is herein described as obtained from the gill filaments of Hyphessobrycon loretoensis caught in the Nanay River, Department of Loreto, Peru. The parasite was found in 37 of 45 (82.2%) examined H. loretoensis. The new species was characterized based on morphological features and 18S rDNA gene sequence data. The sequencing of the 18S rDNA gene from the spores of H...
August 11, 2018: Acta Tropica
Satyanarayana Tatineni, Jeff Alexander, Adarsh K Gupta, Roy French
Wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV), distinct members in the family Potyviridae, are economically important wheat-infecting viruses in the Great Plains region. Previously, we reported that co-infection of wheat by WSMV and TriMV cause disease synergism with increased concentration of both viruses. The mechanisms of synergistic interaction between WSMV and TriMV and the effects of prior infection of wheat by either of these 'synergistically interacting partner' (SIP) viruses on the establishment of local and systemic infection by the other SIP virus are not known...
August 14, 2018: Molecular Plant-microbe Interactions: MPMI
Daniel B Kay, Jared J Tanner, Dawn Bowers
OBJECTIVES: Parkinson's disease (PD) is a multisystem movement disorder associated with sleep disturbance and depression. Sleep disturbances and depression severity share a bidirectional association. This association may be greater in individuals who are more vulnerable to the deleterious consequences of sleep disturbance and depression severity. We investigated whether the association between sleep disturbances and depression severity is greater in patients with PD than in matched controls (MC)...
June 2018: Brain and Behavior
Ravi K Chilukoti, Josefine Lendeckel, Katrin Darm, Alicja Bukowska, Andreas Goette, Marc Sühling, Kirsten Utpatel, Barbara Peters, Georg Homuth, Uwe Völker, Carmen Wolke, Christian Scharf, Uwe Lendeckel
Dronedarone improves microvascular flow during atrial fibrillation and reduces the infarct size in acute models of myocardial infarction. However, dronedarone might be harmful in patients with recent decompensated heart failure and increases mortality in patients with permanent atrial fibrillation. A pathophysiological explanation for these discrepant data is lacking. This study investigated the effects of dronedarone on gene and protein expression in the infarcted area and border zone in pigs subjected to anterior ischemia/reperfusion myocardial infarction...
July 2018: Experimental Biology and Medicine
Maria G Cersosimo, Gabriela B Raina, Luis A Pellene, Federico E Micheli, Cristian R Calandra, Ricardo Maiola
Objectives: To determine the prevalence of weight loss (WL) in PD patients, its relationship to the severity of motor manifestations and appetite changes. Methods: 144 PD patients and 120 controls were evaluated in a single session. All subjects were asked about changes in body weight and appetite. PD patients were examined with the UPDRS-III and the Hoehn and Yahr (HY) scales. Subscores of tremor, bradykinesia /rigidity, and non-dopaminergic symptoms (NDS) were analyzed individually...
2018: BioMed Research International
Rakesh Sanabam, Ng Taibangnganbi Chanu, Susheel Kumar Sharma, S S Roy, M A Ansari, N Prakash
Diverse chilli genetic resources of North East India occupy a unique niche in the Nation's chilli gene pool. Widely cultivated chilli landraces (King chilli: Capsicum chinense , bird eye chilli: Capsicum frutescens and Capsicum annuum ) of North East India in general and Manipur in particular suffer from decline complex due to high incidence of viral diseases. With this background and the known prominent distribution of Chilli veinal mottle virus (ChiVMV) in Asian region, we studied its prevalence and association with diverse symptoms of chilli landraces...
August 2018: 3 Biotech
Shelly Benjaminy, Cody Lo, Judy Illes, Anthony Traboulsee
Background: We sought to characterize the perspectives of participants in Canada's phase I/II chronic cerebrospinal venous insufficiency (CCSVI) clinical trial prior to and after the disclosure of trial results. Methods: This was a researcher-administered survey of individuals who participated in Canada's CCSVI trial (, NCT01864941) about their (1) motivations for participating, (2) understanding of the trial process, and (3) perspectives on the social value of the trial...
June 2018: Neurology. Clinical Practice
Carsten Eggers, Richard Dano, Juliane Schill, Gereon R Fink, Lars Timmermann, Raymond Voltz, Heidrun Golla, Stefan Lorenzl
Background: Palliative care in Parkinson's Disease (PD) patients considerably differs from palliative care in oncology patients. Integrated care models are a concept to support patients and improve management of PD symptoms. However, it is not known if the access to PD patients at the end of life can be achieved through integrated care models. Aim: To analyze an integrated model of care for PD patients with the aim to identify if this integrated model of care has access to PD patients at the end of life. Material and Methods: The Cologne Parkinson's network was designed as a randomized, controlled prospective clinical trial in order to increase quality of life of PD patients...
2018: Frontiers in Neurology
Libo Wang, Jia Li, Jiajun Chen
Background: Levodopa has been widely used and regarded as the most effective therapy for Parkinson's disease (PD), but long-term treatment with oral levodopa may result in motor fluctuations and involuntary movements (dyskinesias). There is evidence to suggest that Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) can effectively manage motor and non-motor complications in PD, but clinical studies investigating this have yielded inconsistent results. This systematic review and meta-analysis was performed to examine the efficacy and safety of LCIG for patients with PD...
2018: Frontiers in Neurology
Ben Sagot, Li Li, Fu-Ming Zhou
Dopamine (DA) profoundly stimulates motor function as demonstrated by the hypokinetic motor symptoms in Parkinson's disease (PD) and by the hyperkinetic motor side effects during dopaminergic treatment of PD. Dopamine (DA) receptor-bypassing, optogenetics- and chemogenetics-induced spike firing of striatal DA D1 receptor (D1R)-expressing, direct pathway medium spiny neurons (dSPNs or dMSNs) promotes movements. However, the endogenous D1R-mediated effects, let alone those of DA replacement, on dSPN spike activity in freely-moving animals is not established...
2018: Frontiers in Neural Circuits
Khalid Almoammar
Vitamin D is known as the oldest of all hormones. 7-Dehydrocholesterol is converted to previtamin D3 . It becomes a secosteroid when it is later converted to 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ). A number of factors influence vitamin D3 production, including skin pigmentation, the use of sunscreen lotions, season, latitude, and altitude. Vitamin D is important for bone metabolism and calcium hemostasis. Researchers have linked a deficiency in vitamin D levels to a number of systemic complications, including cardiovascular disease, diabetes, immune deficiency, and infectious diseases...
2018: Clinical, Cosmetic and Investigational Dentistry
Harvy Mauricio Velasco Parra, Silvia Juliana Maradei Anaya, Johanna Carolina Acosta Guio, Clara Eugenia Arteaga Diaz, Juan Carlos Prieto Rivera
Case Presentation: Pelizaeus Merzbacher Disease (PMD) is an X-linked developmental defect of myelination that causes childhood chronic spastic encephalopathy. Its genetic etiology can be either a duplication (or other gene dosage alterations) or a punctual mutation at the PLP1 locus. Clinically, it presents with developmental delay, nystagmus and, spasticity, supported by neuroimaging in which the defect of myelination is evident. We present a series of seven Colombian patients diagnosed with this leucodystrophy, describing their genotypic and phenotypic characteristics and heterogeneity...
June 30, 2018: Colombia Médica: CM
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