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Tingting Li, Hailing Li, Qing Zhang, Zhenfeng Ma, Lingfei Yu, Yanyu Lu, Zhenguo Niu, Wenjuan Sun, Jia Liu
The alpine wetlands on the Tibetan Plateau (TP) are ecosystems vulnerable to global climate change. It has been recognized that future climate change may have a significant impact on methane (CH4 ) emissions from the plateau, while less attention has been paid to predicting temporal and spatial variations in CH4 emissions from TP natural wetlands. In this study, we used an integrated model framework based on the CH4MODwetland , TOPMODEL and TEM models to predict CH4 emissions from potential natural wetlands on the TP under IPCC AR5 scenarios from 2006 to 2100...
November 28, 2018: Science of the Total Environment
Jinqiang Huang, Yongjuan Li
BACKGROUND: Tibetan sheep (TS) and Gansu Alpine Finewool sheep (GS) are both important plateau sheep raised and fed on the harsh Qinghai-Tibetan Plateau, China. Rumen methanogen and protozoal communities of plateau sheep are affected by their hosts and living environments, and play important roles in ruminant nutrition and greenhouse gas production. However, the characteristics, differences, and associations of these communities remain largely uncharacterized. RESULTS: The rumen methanogen and protozoal communities of plateau sheep were investigated by 16S/18S rRNA gene clone libraries...
December 13, 2018: BMC Microbiology
Jian Wang, YunLing Gao, YiLong Chen, YiWen Chen, Yi Zhang, Li Xiang, Zheng Pan
Lamiophlomis rotata ( L. rotata ), is known as "Daba" in the Tibetan region, Ajuga ovalifolia and Oreosolen wartii have also been utilized as substitutes for "Daba", however, only L. rotata has been officially listed in the Chinese Pharmacopoeia for hemostasis preparations. To safely apply the traditional uses of the herb, internal transcribed spacer 2 (ITS2) DNA barcodes were employed to discriminate L. rotata from its adulterants. For further evaluation of the quality of different originating habitats, the chemical profiles of 25 samples were determined by ultra-high-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-QTOF-MS) coupled with multivariate analyses...
December 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Danba Jiachu, Feng Jiang, Li Luo, Hong Zheng, Ji Duo, Jing Yang, Yongcuo Nima, Jin Ling, Baixiang Xiao, Ken Bassett
Introduction: The only population-based survey of blindness and visual impairment of a Tibetan population was conducted in the Tibet Autonomous Region in 1999. Methods and analysis: The Rapid Assessment of Avoidable Blindness methodology was used to conduct a survey of Kandze Tibetan Autonomous Prefecture, Sichuan Province of China in the Fall 2017. Using the 2010 census, 100 clusters of 50 participants aged 50 years or older were randomly sampled using probability proportionate to size...
2018: BMJ Open Ophthalmology
Peng-Cheng Fu, Hui-Yuan Ya, Qi-Wei Liu, Hui-Min Cai, Shi-Long Chen
Understanding the genetic structure and evolutionary history of plants contributes to their conservation and utilization and helps to predict their response to environmental changes. The wildflower and traditional Chinese and Tibetan medicinal plant Gentiana lawrencei var. farreri is endemic to the Qinghai-Tibetan Plateau (QTP). To explore its genetic structure and evolutionary history, the genetic diversity, divergence, and demographics were analyzed in individuals from 31 locations across the QTP using 1 chloroplast marker and 10 nuclear microsatellite loci...
2018: Frontiers in Genetics
Zhiwen Dong, Dahe Qin, Kaiming Li, Shichang Kang, Ting Wei, Junfeng Lu
Pollutants, which are usually transported from urban cities to remote glacier basins, and aerosol impurities affect the earth's temperature and climate by altering the radiative properties of the atmosphere. This work focused on the physicochemical properties of atmospheric pollutants across the urban and remote background sites in northwest China. Information on individual particles was obtained using transmission electron microscopy (TEM) and energy dispersive X-ray spectrometry (EDX). Particle size and age-dependent mixing structures of individual particles in clean and polluted air were investigated...
December 1, 2018: Environmental Pollution
Ruixue Ye, Yuju Wu, Qingzhi Wang, Min Cao, Tiaoying Li, Xingwang Chen, Huan Zhou
To determine the impact of Cysticercus cellulose (C. cellulose) infection on mental health among school-aged children in Tibetan agricultural areas of Sichuan Province.
 Methods: In October 2015, all primary schools located in Tibetan agricultural areas in Yajiang, Ruoergai, and Muli county of Sichuan Province were selected as the research sites. All school-aged children at five- and six-grade were enrolled for the study by a multistage stratified cluster sampling method. Antibodies against C. cellulose were detected...
October 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Li Lu, Dan-Dan Xu, Huan-Zhong Liu, Ling Zhang, Chee H Ng, Gabor S Ungvari, Weng Tong Wu, Yi-Fan Xiang, Feng-Rong An, Yu-Tao Xiang
PURPOSE: To compare mobile phone addiction (MPA) patterns between Tibetan and Han adolescents in China. DESIGN AND METHODS: The study was carried out in two provinces of China. The Mobile Phone Addiction Scale (MPAS) was used to assess MPA. FINDINGS: Seven hundred and five Tibetan and 606 Han students participated in the study. The MPAS total score was 24.4 ± 11.4 in the whole sample; 27.3 ± 10.8 and 20.9 ± 11.2 in Tibetan and Han students, respectively...
December 4, 2018: Perspectives in Psychiatric Care
Jiufu Luo, Xuemin Liu, Jun Yang, Yuguo Liu, Jinxing Zhou
Plant functional groups (PFGs) have been increasingly introduced in land degradation (LD) studies; however, it is unclear whether PFGs can indicate LD. Here, we selected five different degraded lands (i.e., pristine and, lightly, moderately, seriously and extremely degraded) higher than 4650 m on the Tibetan Plateau. In addition, we investigated floristic metrics (i.e., composition, height, cover, biomass and abundance) and soil conditions (e.g., moisture, temperature and gravel ratio) by sampling 225 subplots...
December 4, 2018: Scientific Reports
Chandar Kumar, Shen Song, Lin Jiang, Xiaohong He, Qianjun Zhao, Yabin Pu, Kanwar Kumar Malhi, Asghar Ali Kamboh, Yuehui Ma
The Tibetan cashmere goat is one of the main goat breeds used by people living in the plateau. It exhibits the distinct phenotypic characteristics observed in lowland goats, allowing them to adapt to the challenging conditions at high altitudes. It provides an ideal model for understanding the genetic mechanisms underlying high-altitude adaptation and hypoxia-related diseases. Our previous exome sequencing of five Chinese cashmere breeds revealed a candidate gene, DSG3 (Desmoglein 3 ), responsible for the high-altitude adaptation of the Tibetan goat...
2018: Frontiers in Genetics
Jinpa Thupten
This opinion paper examines the fundamental question of contemporary mindfulness' connection with ethics and compassion, while adding the voice of the Indo-Tibetan Buddhist perspectives on the current debate on mindfulness and its relation to the Buddhist concept of sati and satipaṭṭhāna meditation. Drawing attention to the threefold training of morality, concentration, and wisdom constituting an important context in Buddhism, the paper argues that in today's secular context, mindfulness practice seemed to have become divorced from its larger ethical framework and soteriological context of a method for attaining liberation, and turned into a technique for quieting the mind and enhancing focus and awareness...
November 14, 2018: Current Opinion in Psychology
Yongdong Chi, Yaou Xu, Fan Luo, Yaqiu Lin, Zhixiong Li
The aim of this study was to clone KLF6 gene of Tibetan chicken, clarify its temporal-spatial expression characteristics, and build the correlation between the expression level of KLF6 gene and IMF content in different developmental stages. RT-PCR was used to clone Tibetan chicken KLF6 gene, qPCR was used to detect the expression level of KLF6 gene in different tissues and developmental stages. The sequence of KLF6 gene was 919 bp including a complete 852 bp CDS region. The gene was highest expression in lung tissues, which was significantly higher than in other tissues (p < 0...
November 30, 2018: Animal Biotechnology
Liwei Tan, Chen Liang, Yeye Wang, Yu Jiang, Shengqiao Zeng, Rui Tan
Oxidative stress and inflammation are important mechanisms of cerebral ischemia reperfusion (IR) injury. Luteolin (Lu), one of the major active components in the classical Tibetan prescription, which has been used in the treatment of cardiovascular diseases since 700 BC, has potential for IR injury therapy. Its hydrophobicity has impeded its further applications. In this study, we first prepared Lu micelles (M-Lu) by self-assembling with an amphiphilic copolymer via the thin film hydration method to improve the dispersion of Lu in water...
November 29, 2018: Pharmaceutics
Chao-Nan Du, Ming-Fei Yang, Qiang Zhang, Xiao-Qing Jin, Chao Yan, Yong-Wei Huang
OBJECTIVE: The latest WHO data showed that stroke was the highest mortality in China, accounting for 23.7% of the total mortality from 2000 to 2012. Intracerebral hemorrhage (ICH) was the most deadly and incurable type of stroke. In the Qinghai-Tibetan Plateau, the incidence of stroke was relatively higher. Several studies showed that the shape and heterogeneity of hematoma and image markers on brain computed tomography (CT) scan had predictive effects on hematoma expansion (HE). The study aimed to find relative factors and established a nomogram model to predict the HE of ICH...
November 27, 2018: World Neurosurgery
Da-Cheng Hao, Pei-Gen Xiao, Chang Liu
Around 70-80% of drugs used in traditional Tibetan medicine (TTM) come from Qinghai Tibet Plateau, the majority of which are plants. The biological and medicinal culture diversity on Qinghai Tibet Plateau are amazing and constitute a less tapped resource for innovative drug research and development. Meanwhile, the problem of the exhausting Tibetan medicine resources is worrying. Here, the latest awareness, as well as the gaps of the traditional Tibetan medicinal plant issues in drug development and clinical usage of TTM compounds, was systematically reviewed and highlighted...
November 30, 2018: Future Medicinal Chemistry
X L Zhang, B B Ha, S J Wang, Z J Chen, J Y Ge, H Long, W He, W Da, X M Nian, M J Yi, X Y Zhou, P Q Zhang, Y S Jin, O Bar-Yosef, J W Olsen, X Gao
The Tibetan Plateau is the highest and one of the most demanding environments ever inhabited by humans. We investigated the timing and mechanisms of its initial colonization at the Nwya Devu site, located nearly 4600 meters above sea level. This site, dating from 40,000 to 30,000 years ago, is the highest Paleolithic archaeological site yet identified globally. Nwya Devu has yielded an abundant blade tool assemblage, indicating hitherto-unknown capacities for the survival of modern humans who camped in this environment...
November 30, 2018: Science
Shouquan Wu, Yu Wang, Guo Chen, Miaomiao Zhang, Minggui Wang, Jian-Qing He
BACKGROUND: 2'-5'-Oligoadenylate synthetase 1 (OAS1) plays an important role in inflammatory immune reactions. OAS1 polymorphisms have been associated with increased susceptibility to various diseases. We investigated the association of polymorphisms in OAS1 with tuberculosis (TB). METHODS: A total of 1215 TB cases and 1114 healthy controls were enrolled from two independent studies. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR) method...
November 29, 2018: BMC Pulmonary Medicine
Hong Pan, Qiuhong Chen, Shenggui Qi, Tengyan Li, Beihong Liu, Shiming Liu, Xu Ma, Binbin Wang
EPAS1 encodes HIF2ɑ and is closely related to high altitude chronic hypoxia. Mutations in the EPAS1 coding sequence are associated with several kinds of human diseases, including syndromic congenital heart disease (CHD). However, whether there are rare EPAS1 coding variants related to Tibetan non-syndromic CHD has not been fully investigated. A group of 286 Tibetan patients with non-syndromic CHD and 250 unrelated Tibetan healthy controls were recruited from Qinghai, China. Sanger sequencing was performed to identify variations in the EPAS1 coding sequence...
November 28, 2018: Bioscience Reports
Rui Zhang, Li Cheng, Tao Zhang, Ting Xu, Meng Li, Wei Yin, Qingling Jiang, Yingming Yang, Tao Hu
Brick tea contains high concentration of fluoride. The aim of the present work was to explore whether and how the brick tea is a risk factor for dental caries and dental fluorosis among Tibetan children in Ganzi. A cross-sectional study was conducted with 368 12-year-old Tibetan children in Ganzi. Dental caries was measured by DMFT index, and dental fluorosis severity was measured by Dean's Index. Community Fluorosis Index was used to estimate public health significance of dental fluorosis. Oral health-related behaviors and awareness, dietary habits and socioeconomic status were determined by a questionnaire...
November 27, 2018: Environmental Geochemistry and Health
Xiang Sheng, Yali Wang, Jiashuo Zhang, Liqin Chen, Yuan Lin, Zhenmin Zhao, Chengtao Li, Suhua Zhang
A forensic validation study of the Early Access Huaxia™ Platinum Polymerase Chain Reaction (PCR) kit was completed to document the performance capabilities and limitations. The genotyping of DNA samples was consistent across a large range of template DNA concentrations, with complete profiles obtained at 0.125 ng; however, no more than 2 mm × 1.2 mm punches of samples would be recommended for direct amplification. The size precision and accuracy test revealed the genotyping ability; while consistent results were obtained when comparing the kit with other commercially available systems...
2018: Forensic sciences research
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