keyword
MENU ▼
Read by QxMD icon Read
search

Gastric Cáncer Molecular Classification

keyword
https://www.readbyqxmd.com/read/30474028/evaluating-clinical-genome-sequence-analysis-by-watson-for-genomics
#1
Kota Itahashi, Shunsuke Kondo, Takashi Kubo, Yutaka Fujiwara, Mamoru Kato, Hitoshi Ichikawa, Takahiko Koyama, Reitaro Tokumasu, Jia Xu, Claudia S Huettner, Vanessa V Michelini, Laxmi Parida, Takashi Kohno, Noboru Yamamoto
Background: Oncologists increasingly rely on clinical genome sequencing to pursue effective, molecularly targeted therapies. This study assesses the validity and utility of the artificial intelligence Watson for Genomics (WfG) for analyzing clinical sequencing results. Methods: This study identified patients with solid tumors who participated in in-house genome sequencing projects at a single cancer specialty hospital between April 2013 and October 2016. Targeted genome sequencing results of these patients' tumors, previously analyzed by multidisciplinary specialists at the hospital, were reanalyzed by WfG...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30370510/-pathological-evaluation-system-for-preoperative-treatment-of-gastric-cancer
#2
Qianchen Ma, Fei Yuan
As the perioperative chemotherapy and conversion therapy has been widely implemented on the standard treatment of gastric cancer patients, it is of great importance to evaluate the efficacy of these patients accurately by effective methods. Being an important grading standard for histomorphological evaluation of excision specimens after neoadjuvant chemotherapy, pathological tumor regression grade (TRG) system is mainly used to assess the degree of fibrosis of tumor tissue and the proportion of residual tumor cells...
October 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30370509/-development-trend-of-assessment-system-in-gastric-cancer-based-on-evolution-of-staging-criteria
#3
Lingyu Sun
There are two major stage classification systems for gastric cancer: the tumor-node-metastasis (TNM) staging by the International Union against Cancer (UICC)/the American Joint Committee on Cancer(AJCC) and the Japanese Classification of Gastric Carcinoma by the Japanese Gastric Cancer Association(JGCA). The evolution of these two systems showed the advancement of gastric cancer treatment. The independence of TNM and JGCA staging system is not conducive to global communication and cooperation. The integration of 2010 Japan's 14th edition of the General Rules for Gastric Cancer Study and the 7th edition of UICC/AJCC TNM staging formed an internationally unified clinical staging system...
October 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30311375/specifications-of-the-acmg-amp-variant-curation-guidelines-for-the-analysis-of-germline-cdh1-sequence-variants
#4
Kristy Lee, Kate Krempely, Maegan E Roberts, Michael J Anderson, Fatima Carneiro, Elizabeth Chao, Katherine Dixon, Joana Figueiredo, Rajarshi Ghosh, David Huntsman, Pardeep Kaurah, Chimene Kesserwan, Tyler Landrith, Shuwei Li, Arjen R Mensenkamp, Carla Oliveira, Carolina Pardo, Tina Pesaran, Matthew Richardson, Thomas P Slavin, Amanda B Spurdle, Mackenzie Trapp, Leora Witkowski, Charles S Yi, Liying Zhang, Sharon E Plon, Kasmintan A Schrader, Rachid Karam
The variant curation guidelines published in 2015 by the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) provided the genetics community with a framework to assess variant pathogenicity; however, these rules are not gene specific. Germline pathogenic variants in the CDH1 gene cause hereditary diffuse gastric cancer and lobular breast cancer, a clinically challenging cancer predisposition syndrome that often requires a multidisciplinary team of experts to be properly managed...
November 2018: Human Mutation
https://www.readbyqxmd.com/read/30271341/emerging-therapies-in-the-management-of-advanced-stage-gastric-cancer
#5
REVIEW
Vivek Kumar, Parita Soni, Mohit Garg, Stephan Kamholz, Abhinav B Chandra
Globally, gastric malignancy contributes to significant cancer-related morbidity and mortality. Despite a recent approval of two targeted agents, trastuzumab and ramucirumab, the treatment options for advanced-stage gastric cancer are limited. Consequently, the overall clinical outcomes for patients with advanced-stage gastric cancer remain poor. Numerous agents that are active against novel targets have been evaluated in the course of randomized trials; however, most have produced disappointing results because of the molecular heterogeneity of gastric cancer...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30216380/dissecting-cancer-heterogeneity-based-on-dimension-reduction-of-transcriptomic-profiles-using-extreme-learning-machines
#6
Kejun Wang, Xin Duan, Feng Gao, Wei Wang, Liangliang Liu, Xin Wang
It is becoming increasingly clear that major malignancies such as breast, colorectal and gastric cancers are not single disease entities, but comprising multiple cancer subtypes of distinct molecular properties. Molecular subtyping has been widely used to dissect inter-tumor biological heterogeneity, in relation to clinical outcomes. A key step of this methodology is to perform unsupervised classification of gene expression profiles, which, however, often suffers challenges of high-dimensionality, feature redundancy as well as noise and irrelevant information...
2018: PloS One
https://www.readbyqxmd.com/read/30197478/long-non-coding-rnas-involved-in-metastasis-of-gastric-cancer
#7
REVIEW
Meng-Ting Lin, Hao-Jun Song, Xiao-Yun Ding
Gastric cancer (GC) is one of the most frequently diagnosed malignant diseases. The molecular mechanisms of metastasis remain unclear. Recently, studies have shown that long non-coding RNAs (lncRNAs) play critical roles in metastasis. Therefore, deeper understanding of this mechanism could provide potential diagnostic tools and therapeutic targets for metastatic GC. This review focuses on dysregulated lncRNAs in GC metastases. Due to the identification of multiple diverse mechanisms involved in GC metastasis, we classified them into seven categories, including lncRNAs related to epithelial-mesenchymal transition, regulation of degradation of extracellular matrix, angiopoiesis, vasculogenic mimicry, and immunologic escape...
September 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30140949/immunohistochemical-classification-of-gastric-cancer-based-on-new-molecular-biomarkers-a-potential-predictor-of-survival
#8
Cristina Díaz Del Arco, Lourdes Estrada Muñoz, Elena Molina Roldán, Mª Ángeles Cerón Nieto, Luis Ortega Medina, Soledad García Gómez de Las Heras, Mª Jesús Fernández Aceñero
Several classification systems have been described for stratifying patients with gastric carcinoma (GC). However, their prognostic value is low, and there is an urgent need for identification of molecular markers and development of new classifications. Retrospective study of 206 cases of GC diagnosed and surgically resected in our hospital between 2000 and 2017. Clinicopathological features of all cases were assessed and tissue microarrays were constructed for immunohistochemical (IHC) study. Patients were stratified based on IHC results...
December 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30106137/gene-regulatory-network-construction-identified-nfya-as-a-diffuse-subtype-specific-prognostic-factor-in-gastric-cancer
#9
Bin Cao, Yu Zhao, Zheng Zhang, Hengcun Li, Jie Xing, Shuilong Guo, Xintao Qiu, Shutian Zhang, Li Min, Shengtao Zhu
Lauren classification is a pathology-based gastric cancer (GC) subtyping system, which is widely used in the clinical treatment of patients with GC. However, genome-scale molecular characteristics to distinguish between diffuse (DF) and intestinal (IT) GC remain incompletely characterized, particularly at the transcriptional regulatory level. In the present study, gene regulatory networks were constructed using the Passing Attributes between Networks for Data Assimilation (PANDA) algorithm for DF, IT and mixed GC...
November 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30027089/immunotherapy-in-advanced-gastric-cancer-an-overview-of-the-emerging-strategies
#10
REVIEW
Helena Magalhães, Mário Fontes-Sousa, Manuela Machado
Gastric cancer (GC) remains a public health problem, being the fifth most common cancer worldwide. In the western countries, the majority of patients present with advanced disease. Additionally, 65 to 75% of patients treated with curative intent will relapse and develop systemic disease. In metastatic disease, systemic treatment still represents the state of the art, with less than a year of median overall survival. The new molecular classification of GC was published in 2014, identifying four distinct major subtypes of gastric cancer, and has encouraged the investigation of new and more personalized treatment strategies...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30018477/biomarkers-of-gastric-cancer-current-topics-and-future-perspective
#11
REVIEW
Tasuku Matsuoka, Masakazu Yashiro
Gastric cancer (GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. This cancer is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Although the incidence is declining, the outcome of patients with GC remains dismal. Thus, the detection at an early stage utilizing useful screening approaches, selection of an appropriate treatment plan, and effective monitoring is pivotal to reduce GC mortalities...
July 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30008616/molecular-biomarkers-in-gastro-esophageal-cancer-recent-developments-current-trends-and-future-directions
#12
REVIEW
Francesca Battaglin, Madiha Naseem, Alberto Puccini, Heinz-Josef Lenz
Gastro-esophageal adenocarcinomas (GEA) represent a severe global health burden and despite improvements in the multimodality treatment of these malignancies the prognosis of patients remains poor. HER2 overexpression/amplification has been the first predictive biomarker approved in clinical practice to guide patient selection for targeted treatment with trastuzumab in advanced gastric and gastro-esophageal junction cancers. More recently, immunotherapy has been approved for the treatment of GEA and PD-L1 expression is now a biomarker required for the administration of pembrolizumab in these diseases...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29896679/gastritis-infection-cancer-sequence-of-epstein-barr-virus-associated-gastric-cancer
#13
REVIEW
Masashi Fukayama, Akiko Kunita, Atsushi Kaneda
Epstein-Barr virus-associated gastric cancer (EBVaGC) is a representative EBV-infected epithelial neoplasm, which is now included as one of the four subtypes of The Cancer Genome Atlas molecular classification of gastric cancer. In this review, we portray a gastritis-infection-cancer sequence of EBVaGC. This virus-associated type of gastric cancer demonstrates clonal growth of EBV-infected epithelial cells within the mucosa of atrophic gastritis. Its core molecular abnormality is the EBV-specific hyper-epigenotype of CpG island promoter methylation, which induces silencing of tumor suppressor genes...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29882766/proposed-molecular-and-mirna-classification-of-gastric-cancer
#14
REVIEW
Lara Alessandrini, Melissa Manchi, Valli De Re, Riccardo Dolcetti, Vincenzo Canzonieri
Gastric cancer (GC) is a common malignant neoplasm worldwide and one of the main cause of cancer-related deaths. Despite some advances in therapies, long-term survival of patients with advanced disease remains poor. Different types of classification have been used to stratify patients with GC for shaping prognosis and treatment planning. Based on new knowledge of molecular pathways associated with different aspect of GC, new pathogenetic classifications for GC have been and continue to be proposed. These novel classifications create a new paradigm in the definition of cancer biology and allow the identification of relevant GC genomic subsets by using different techniques such as genomic screenings, functional studies and molecular or epigenetic characterization...
June 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29844297/immunotherapy-for-gastric-cancer-time-for-a-personalized-approach
#15
REVIEW
Riccardo Dolcetti, Valli De Re, Vincenzo Canzonieri
Over the last decade, our understanding of the mechanisms underlying immune modulation has greatly improved, allowing for the development of multiple therapeutic approaches that are revolutionizing the treatment of cancer. Immunotherapy for gastric cancer (GC) is still in the early phases but is rapidly evolving. Recently, multi-platform molecular analyses of GC have proposed a new classification of this heterogeneous group of tumors, highlighting subset-specific features that may more reliably inform therapeutic choices, including the use of new immunotherapeutic drugs...
May 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29843478/clinical-importance-of-epstein%C3%A2-barr-virus-associated-gastric-cancer
#16
REVIEW
Jun Nishikawa, Hisashi Iizasa, Hironori Yoshiyama, Kanami Shimokuri, Yuki Kobayashi, Sho Sasaki, Munetaka Nakamura, Hideo Yanai, Kohei Sakai, Yutaka Suehiro, Takahiro Yamasaki, Isao Sakaida
Epstein⁻Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors...
May 29, 2018: Cancers
https://www.readbyqxmd.com/read/29796937/clinical-impact-of-molecular-classifications-in-gastric-cancer
#17
REVIEW
Daniele Marrelli, Karol Polom, Alessandro Neri, Franco Roviello
Treatment options to gastric cancer (GC) have been changing in recent years from a standard to a tailored approach. Different individualized procedures can range from endoscopic resection, D2 with open or minimally invasive approach, to neo-adjuvant therapy followed by extended surgery. In more advanced stages, a combined approach with the inclusion of intraperitoneal chemo-hyperthermia (HIPEC) may represent a new advanced option. The inclusion of histological type according to Laurén classification in the flowchart of treatment could increase both accuracy and effectiveness of such tailored approach...
June 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29760539/new-therapeutic-options-opened-by-the-molecular-classification-of-gastric-cancer
#18
REVIEW
Mihaela Chivu-Economescu, Lilia Matei, Laura G Necula, Denisa L Dragu, Coralia Bleotu, Carmen C Diaconu
Gastric cancer (GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29743854/microsatellite-instability-in-colorectal-cancer
#19
REVIEW
Jafar Nouri Nojadeh, Shahin Behrouz Sharif, Ebrahim Sakhinia
Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of genetic and environmental factors. Although it is one of the most common cancers worldwide, CRC would be one of the most curable cancers if it is detected in the early stages. Molecular changes that occur in colorectal cancer may be categorized into three main groups: 1) Chromosomal Instability (CIN), 2) Microsatellite Instability (MSI), and 3) CpG Island Methylator phenotype (CIMP). Microsatellites, also known as Short Tandem Repeats (STRs) are small (1-6 base pairs) repeating stretches of DNA scattered throughout the entire genome and account for approximately 3 % of the human genome...
2018: EXCLI journal
https://www.readbyqxmd.com/read/29721214/distinct-molecular-subtypes-of-gastric-cancer-from-laur%C3%A3-n-to-molecular-pathology
#20
REVIEW
Magdalena Cisło, Agata Anna Filip, George Johan Arnold Offerhaus, Bogumiła Ciseł, Karol Rawicz-Pruszyński, Małgorzata Skierucha, Wojciech Piotr Polkowski
In Western countries the majority of gastric cancers (GC) are usually diagnosed in advanced stages reporting a 5-year survival rate of only 26%. The Laurén classification of GC was most widely used in clinical practice since it reflects GC morphology, epidemiology, tumor biology, clinical management and outcome. Despite the initial promise of individualizing antitumor treatment, the management of GC still remains relatively broad and general. Apart from clinical staging, molecular profiling enables targeting of the identified underlying alterations, rather than histology...
April 10, 2018: Oncotarget
keyword
keyword
171758
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"