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https://www.readbyqxmd.com/read/30553031/zika-virus-diagnosis-challenges-and-solutions
#1
REVIEW
Rebecca Peters, Mario Stevenson
BACKGROUND: Since its sudden appearance and link to microcephaly in 2015, the number of PubMed references for Zika virus (ZIKV) has risen from 181 to 5,163, as of writing, with a vast proportion focused on the consequences of ZIKV infection during pregnancy. This level of attention underlies increased demand for sensitive and specific diagnostic tools able to assess risk to an unborn child, as well as to understand the dynamics and consequences of viral persistence. AIM: Review the expanding knowledge on ZIKV persistence and diagnostic challenges and summarize current advancements in detection...
December 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30552880/arbovirus-investigation-in-patients-from-mato-grosso-during-zika-and-chikungunya-virus-introdution-in-brazil-2015-2016
#2
Michell Charlles de Souza Costa, Laura Marina Siqueira Maia, Victor Costa de Souza, Andréia Maria Gonzaga, Vergínia Correa de Azevedo, Letícia Ramos Martins, Juliana Helena Chaves Pavoni, Felipe Gomes Naveca, Renata Dezengrini Slhessarenko
Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less than five days in Mato Grosso state (MT) during the period of ZIKV and CHIKV dissemination in Brazil. To achieve that, 453 human serum samples of patients suspected of Dengue (DENV), Yellow Fever (YFV), ZIKV or CHIKV collected in health units of 31 cities of MT were subjected to RT-PCR protocols for 10 flaviviruses, 5 alphaviruses and orthobunyaviruses from Simbu serogroup, nucleotide sequencing and viral isolation...
December 12, 2018: Acta Tropica
https://www.readbyqxmd.com/read/30552825/regression-of-human-immunodeficiency-virus-associated-oral-kaposi-sarcoma-with-combined-antiretroviral-therapy-a-case-report-and-literature-review
#3
Juliana Bertoldi Franco, Loreto José Maureira Pena, Fabiana Martins E Martins, Marcio Augusto de Oliveira, Karem L Ortega
BACKGROUND: Kaposi's sarcoma (KS) is the most prevalent malignant neoplasia in human immunodeficiency virus positive (HIV+) patients for which the primary mode of management was chemotherapy. METHODS: We have presented the case of a newly diagnosed HIV+ male patient who was diagnosed with a pedunculated nodule in the anterior region of the hard palate, measuring 3.5 cm in diameter and with 2 months of evolution. RESULTS: Histopathological examination confirmed the clinical hypothesis of KS...
December 15, 2018: Head & Neck
https://www.readbyqxmd.com/read/30552620/molecular-mimicry-genetic-homology-and-gene-sharing-proteomic-molecular-fingerprints-using-an-ebv-epstein-barr-virus-derived-microarray-as-a-potential-diagnostic-method-in-autoimmune-disease
#4
REVIEW
David H Dreyfus, Antonella Farina, Giuseppina Alessandra Farina
EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinase expressed primarily during the viral lytic replication cycle, and EBNA-1 (Epstein-Barr Virus Nuclear Antigen) expressed during the viral latency cycle respectively were characterized using a laser-printed micro-array ( PEPperprint...
December 15, 2018: Immunologic Research
https://www.readbyqxmd.com/read/30551738/clinical-immunological-and-bacteriological-characteristics-of-h7n9-patients-nosocomially-co-infected-by-acinetobacter-baumannii-a-case-control-study
#5
William J Liu, Rongrong Zou, Yongfei Hu, Min Zhao, Chuansong Quan, Shuguang Tan, Kai Luo, Jing Yuan, Haixia Zheng, Jue Liu, Min Liu, Yuhai Bi, Jinghua Yan, Baoli Zhu, Dayan Wang, Guizhen Wu, Lei Liu, Kwok-Yung Yuen, George F Gao, Yingxia Liu
BACKGROUND: Bacterial co-infection of patients suffering from influenza pneumonia is a key element that increases morbidity and mortality. The occurrence of Acinetobacter baumannii co-infection in patients with avian influenza A (H7N9) virus infection has been described as one of the most prevalent bacterial co-infections. However, the clinical and laboratory features of this entity of H7N9 and A. baumannii co-infection have not been systematically investigated. METHODS: We collected clinical and laboratory data from laboratory-confirmed H7N9 cases co-infected by A...
December 14, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30551205/serologic-status-of-routine-childhood-vaccines-cytomegalovirus-and-epstein-barr-virus-in-children-with-inflammatory-bowel-disease
#6
Jennifer C C deBruyn, Ing Shian Soon, Kevin Fonseca, Sharon Feng, Melanie Purtzki, Caitlin Goedhart, Susan Kuhn, Otto G Vanderkooi, Iwona Wrobel
Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD. Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD...
December 14, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30549985/changes-in-prealbumin-and-body-mass-index-associated-with-t-lymphocyte-subsets-and-nutritional-status-in-chronic-hepatitis-b-and-hbv-cirrhosis-patients
#7
Wen Gao, Ming Kong, Jia Yao, Fan Wang, Jing Liu, Dongmei Wang, Hongbo Ma, Lieqing Ma, Zhongping Duan
<i>Background:</i> Patient immune response is one of the main factors influencing hepatitis virus (HBV) eradication or chronicity. Our study aimed to investigate the relationship between the nutritional status and immune function, and to provide the appropriate clinical diagnosis data for treatment of patients with chronic hepatitis B virus (CHB) and cirrhosis. <i>Methods:</i> T lymphocyte subsets were tested using flow cytometry in 100 patients (48 with CHB, 52 with cirrhosis) and 26 healthy individuals...
October 31, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30549982/does-adenovirus-and-coxsackie-b-virus-infection-play-a-role-in-tracheobronchopathia-osteochondroplastica-to
#8
Yan L Ge, Cong H Liu, Meng H Wang, Zhen Z Li, Xue Zhang, Hua L Yu, Ai S Fu, Hong Y Wang
<i>Background:</i> Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease. We report a case of TO. <i>Methods:</i> Chest CT scan and bronchoscope with biopsy was performed for diagnosis and blood tests explored for the latent etiology. <i>Results:</i> Chest CT scan and bronchoscopic images showed multiple nodular protrusions in the trachea and main bronchi. Histopathology demonstrated sub-mucosal ossification and inflammatory cell infiltration. Laboratory inspection showed adenovirus and coxsackie B virus IgM antibodies were positive...
October 31, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30546827/decreased-long-intergenic-noncoding-rna-p7-predicts-unfavorable-prognosis-and-promotes-tumor-proliferation-via-the-modulation-of-the-stat1-mapk-pathway-in-hepatocellular-carcinoma
#9
Sijie Cheng, Tieling Li, Cheng Wang, Keyu Wang, Chengcai Lai, Jin Yan, Hongxia Fan, Fang Sun, Zhaohai Wang, Peirui Zhang, Linxiang Yu, Zhixian Hong, Guanglin Lei, Baijun Sun, Yuan Gao, Zhaohui Xiao, Xu Ji, Ruilan Wang, Jianzhong Wu, Xiliang Wang, Shaogeng Zhang, Penghui Yang
Hepatocellular carcinoma (HCC) is the most common neoplasm and is a leading cause of cancer-related death. Despite advances in the diagnosis and management of HCC, its prognosis remain unfavorable. Accumulating evidence has shown that long intergenic noncoding RNAs (lincRNAs) play central roles in the development of HCC. In this study, we identified a long intergenic noncoding RNA referred to as lincRNA P7 in HCC and explored its clinical significance and biological functions in HCC. The expression level of lincRNA P7 was significantly aberrantly deceased in HCC cancer tissues and cells lines...
November 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/30546447/identification-of-a-role-for-serum-aldo-keto-reductase-family-1-member-b10-in-early-detection-of-hepatocellular-carcinoma
#10
Chao Han, Lanzhu Gao, Han Bai, Xiaoguang Dou
Despite improved screening programs, the vast majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. A lack of effective diagnosis methods for preclinical HCC has resulted in a low rate of early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. However, to the best of our knowledge, the diagnostic value of AKR1B10 in early stage HCC is poorly understood. In the current study, the diagnostic performance of serum AKR1B10 in hepatitis B virus/hepatitis C virus (HBV/HCV)-related liver disorders was evaluated and the unique role of AKR1B10 in diagnosing HCC was assessed...
December 2018: Oncology Letters
https://www.readbyqxmd.com/read/30546413/dynamic-changes-and-diagnostic-and-prognostic-significance-of-serum-pct-hs-crp-and-s-100-protein-in-central-nervous-system-infection
#11
Jiaan Wang, Xicai Wu, Yufeng Tian, Xueyuan Li, Xia Zhao, Min Zhang
The aim of the study was to analyze the dynamic changes and diagnostic and prognostic significance of serum procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP) and s-100 protein in central nervous system infection. A total of 110 patients diagnosed with central nervous system infection in Department of Neurology in the People's Hospital of Rizhao from January 2014 to January 2016 were selected and retrospectively analyzed; they were divided into the bacterium (n=70) and virus (n=40) groups. Another 45 normal subjects were selected as the control group...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30546351/involvement-of-human-papillomaviruses-in-cervical-cancer
#12
REVIEW
Xuelian Wang, Xiumin Huang, Youzhong Zhang
Human papillomaviruses (HPV) are the first viruses to have been acknowledged to prompt carcinogenesis, and they are linked with cancers of the uterine cervix, anogenital tumors, and head and neck malignancies. This paper examines the structure and primary genomic attributes of HPV and highlights the clinical participation of the primary HPV serotypes, focusing on the roles that HPV-16 and 18 play in carcinogenesis. The mechanisms that take place in the progression of cervical neoplasia are described. The oncogenic proteins E6 and E7 disrupt control of the cell cycle by their communication with p53 and retinoblastoma protein...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30545683/fat-mass-ratio-in-brazilian-hiv-infected-patients-under-antiretroviral-therapy-and-its-relationship-with-anthropometric-measurents
#13
Amanda Bicudo Bruno Nogueira, Juliana Mendes Abreu, Mariana Mesquita Villela, Ana Elisa Boracini Sanchez, Beatriz Silva Chaves, Sergio Setubal, Luis Guillermo Coca Velarde, Rubens Antunes da Cruz Filho, Giovanna Aparecida Balarini Lima, Debora Vieira Soares
INTRODUCTION: Human immunodeficiency virus-related lipodystrophy is characterized by a variety of phenotypes and metabolic changes; however, consensus has not yet been reached on its diagnostic criteria. Different cutoff values for fat mass ratio have been proposed for this specific population as an objective diagnostic criterion for lipodystrophy. This study aimed to establish sex-specific reference values for fat mass ratio and to correlate them with anthropometric measurements for the diagnosis of human immunodeficiency virus-related lipodystrophy...
August 22, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/30545147/parechovirus-a-detection-by-a-comprehensive-approach-in-a-clinical-laboratory
#14
Bao-Chen Chen, Jenn-Tzong Chang, Tsi-Shu Huang, Jih-Jung Chen, Yao-Shen Chen, Ming-Wei Jan, Tsung-Hsien Chang
Parechovirus A (Human parechovirus, HPeV) causes symptoms ranging from severe neonatal infection to mild gastrointestinal and respiratory disease. Use of molecular approaches with RT-PCR and genotyping has improved the detection rate of HPeV. Conventional methods, such as viral culture and immunofluorescence assay, together with molecular methods facilitate comprehensive viral diagnosis. To establish the HPeV immunofluorescence assay, an antibody against HPeV capsid protein VP0 was generated by using antigenic epitope prediction data...
December 12, 2018: Viruses
https://www.readbyqxmd.com/read/30544883/recent-advances-in-aiv-biosensors-composed-of-nanobio-hybrid-material
#15
REVIEW
Taek Lee, Jae-Hyuk Ahn, Sun Yong Park, Ga-Hyeon Kim, Jeonghyun Kim, Tae-Hyung Kim, Inho Nam, Chulhwan Park, Min-Ho Lee
Since the beginning of the 2000s, globalization has accelerated because of the development of transportation systems that allow for human and material exchanges throughout the world. However, this globalization has brought with it the rise of various pathogenic viral agents, such as Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), Zika virus, and Dengue virus. In particular, avian influenza virus (AIV) is highly infectious and causes economic, health, ethnical, and social problems to human beings, which has necessitated the development of an ultrasensitive and selective rapid-detection system of AIV...
December 9, 2018: Micromachines
https://www.readbyqxmd.com/read/30543600/low-and-decreasing-prevalence-and-rate-of-false-positive-hiv-diagnosis-ch%C3%A3-kw%C3%A3-district-mozambique-2014-2017
#16
Daniel Shodell, Robert Nelson, Duncan MacKellar, Ricardo Thompson, Isabelle Casavant, Didier Mugabe, Sherri Pals, Dawud Ujamaa, Juvencio Bonzela, Judite Cardoso, Salvador Machava, Carlos Lourenço, Chunfu Yang, Bharat Parekh, Ishani Pathmanathan, Andrew F Auld, Stelio Tamele, Manuel Antonio Ouane, Vania Macome, Noela Chicuecue, Guita Amane, Luciana Kohatsu, Nely Honwana, Stanley Wei, Peter R Kerndt, Edgar Monterroso, Alfredo Vergara
In 2017, rapid human immunodeficiency virus (HIV) testing services enabled the HIV diagnosis and treatment of approximately 15.3 million persons with HIV infection in sub-Saharan Africa with life-saving antiretroviral therapy (ART) (1). Although suboptimal testing practices and misdiagnoses have been reported in sub-Saharan Africa and elsewhere, trends in population burden and rate of false positive HIV diagnosis (false diagnosis) have not been reported (2,3). Understanding the population prevalence and trends of false diagnosis is fundamental for guiding rapid HIV testing policies and practices...
December 14, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/30541932/comprehensive-evaluation-of-differential-serodiagnosis-between-zika-and-dengue-viral-infection
#17
Day-Yu Chao, Matthew T Whitney, Brent S Davis, Freddy A Medina, Jorge L Munoz, Gwong-Jen J Chang
Diagnostic testing for Zika virus (ZIKV) or dengue virus (DENV) infection can be accomplished by a nucleic acid detection method; however, a negative result does not exclude infection due to the low virus titer during infection depending on the timing of sample collection. Therefore, a ZIKV- or DENV-specific serological assay is essential for the accurate diagnosis of patients and to mitigate potential severe health outcomes. A retrospective study design with dual approaches of collecting human serum samples for testing was developed...
December 12, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/30541871/practical-guidance-for-clinical-microbiology-laboratories-viruses-causing-acute-respiratory-tract-infections
#18
Carmen L Charlton, Esther Babady, Christine C Ginocchio, Todd F Hatchette, Robert C Jerris, Yan Li, Mike Loeffelholz, Yvette S McCarter, Melissa B Miller, Susan Novak-Weekley, Audrey N Schuetz, Yi-Wei Tang, Ray Widen, Steven J Drews
SUMMARYRespiratory viral infections are associated with a wide range of acute syndromes and infectious disease processes in children and adults worldwide. Many viruses are implicated in these infections, and these viruses are spread largely via respiratory means between humans but also occasionally from animals to humans. This article is an American Society for Microbiology (ASM)-sponsored Practical Guidance for Clinical Microbiology (PGCM) document identifying best practices for diagnosis and characterization of viruses that cause acute respiratory infections and replaces the most recent prior version of the ASM-sponsored Cumitech 21 document, Laboratory Diagnosis of Viral Respiratory Disease , published in 1986...
January 2019: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/30541588/combined-use-of-elisa-and-western-blot-with-recombinant-n-protein-is-a-powerful-tool-for-the-immunodiagnosis-of-avian-infectious-bronchitis
#19
Paula Fonseca Finger, Michele Soares Pepe, Luana Alves Dummer, Carolina Georg Magalhães, Clarissa Caetano de Castro, Silvia de Oliveira Hübner, Fábio Pereira Leivas Leite, Giseli Aparecida Ritterbusch, Paulo Augusto Esteves, Fabricio Rochedo Conceição
BACKGROUND: The avian infectious bronchitis virus (IBV) remains a significant source of loss in the poultry industry and early diagnosis is required to prevent the disease from spreading. This study examined the combined use of an ELISA and Western blot (WB) to detect antibodies against the nucleocapsid protein (N) of IBV. The coding sequence for N was amplified by RT-PCR and expressed in Escherichia coli. A soluble recombinant N protein (rN) of approximately 50 kDa was obtained. A total of 389 sera were tested against the rN in ELISA and the results were compared with those of the commercial IDEXX IBV Ab test...
December 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/30541456/dengue-fever-in-dar-es-salaam-tanzania-clinical-features-and-outcome-in-populations-of-black-and-non-black-racial-category
#20
Noémie Boillat-Blanco, Belia Klaassen, Zainab Mbarack, Josephine Samaka, Tarsis Mlaganile, John Masimba, Leticia Franco Narvaez, Aline Mamin, Blaise Genton, Laurent Kaiser, Valérie D'Acremont
BACKGROUND: Although the incidence of dengue across Africa is high, severe dengue is reported infrequently. We describe the clinical features and the outcome of dengue according to raceduring an outbreak in Dar es Salaam, Tanzania that occurred in both native and expatriate populations. METHODS: Adults with confirmed dengue (NS1 and/or IgM on rapid diagnostic test and/or PCR positive) were included between December 2013 and July 2014 in outpatient clinics. Seven-day outcome was assessed by a visit or a call...
December 12, 2018: BMC Infectious Diseases
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