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A Claßen, T Buhl, S Schubert, M Worm, A Bauer, J Geier, S Molin
BACKGROUND: Earlier studies suggested an inverse association between contact allergy and psoriasis, although the results of clinical studies have been inconsistent. Gene-expression studies in human contact allergy focusing on immune responses revealed nickel being an inducer of Th1/Th17 and some Th22 immune polarization, whereas fragrances were found to promote a Th2-dominated immune activation. OBJECTIVES: To investigate (i) the epidemiological association between contact allergy and psoriasis in a large multicenter cohort and (ii) to analyze the sensitization profile to specific allergens in these patients...
August 12, 2018: British Journal of Dermatology
Shuqian Wang, Yinan Yao, Minya Yao, Peifen Fu, Weilin Wang
PURPOSE: Owing to the absence of any targeted therapies, triple negative breast cancer (TNBC), which accounts for approximately 15% of all breast cancers, typically have a poorer outcome. In an attempt to find out the TNBCs' microenvironment, we ran into the endogenous expression of a newly discovered cytokine known as Interleukin (IL)-22. METHODS: Thirty TNBC patients were recruited and the levels of IL-22 producing (Th22) cells in tumor, paratumor and normal breast tissues were measured...
July 23, 2018: Biochemical and Biophysical Research Communications
Éric Toussirot, Caroline Laheurte, Béatrice Gaugler, Damien Gabriel, Philippe Saas
The IL-23/T helper 17 (Th17) axis plays an important role in joint inflammation in ankylosing spondylitis (AS). Conventional CD4+ Th17 cells are a major source of IL-17A. IL-22 is another cytokine implicated in AS pathophysiology and is produced by Th17 and Th22 cells. In this study, we aimed to analyze conventional and non-conventional T cell subsets producing IL-17A and IL-22 in patients with AS. We thus evaluated the intracellular staining for IL-17A, IL-22, and IFN-γ in peripheral blood mononuclear cells of 36 patients with AS and 55 age- and sex-matched healthy controls (HC)...
2018: Frontiers in Immunology
Ma Liang, Zhang Liwen, Zhuang Yun, Ding Yanbo, Chen Jianping
This study is aimed at examining the potential role of regulatory T- (Treg-) Th1-Th17-Th22 cells in the pathogenic process of autoimmune hepatitis (AIH). The numbers of Foxp3+ Tregs and Th1, Th17, and Th22 cells were measured in 32 AIH patients using flow cytometry. Moreover, a murine model of experimental autoimmune hepatitis (EAH) was also established and used to investigate the function of Treg-Th1-Th17-Th22 cells in disease progression. AIH patients undergoing an active state had significantly decreased numbers of CD3+ CD4+ CD25+ Foxp3+ Tregs and increased numbers of CD3+ CD4+ CD25- Foxp3+ T, CD3+ CD4+ IFN- γ + Th1, CD3+ CD4+ IL-17+ Th17, and CD3+ CD4+ IL-2+ Th22 cells as well as higher levels of Th1/Th17/Th22-type cytokines compared to AIH patients in remission and HC...
2018: Journal of Immunology Research
Cristina Albanesi, Stefania Madonna, Paolo Gisondi, Giampiero Girolomoni
Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic, environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of psoriasis have been elucidated, and, in the current model, the cross talk between autoreactive T cells and resident keratinocytes generates inflammatory and immune circuits responsible for the initiation, progression, and persistence of the disease. Several autoantigens derived from keratinocytes (i.e., LL37 cathelecidin/nucleic acid complexes, newly generated lipid antigens) have been identified, which may trigger initial activation of T cells, particularly IL-17-producing T cells, T helper (Th)1 and Th22 cells...
2018: Frontiers in Immunology
Farinaz Behfarjam, Zohreh Jadali
BACKGROUND Previous studies have indicated an elevated level of serum Interleukin (IL)-22 in patients with autoimmune hepatitis (AIH). However, there are no experimental data on the master transcription factor (aryl hydrocarbon receptor) that plays an important role in the development of T helper type 22 (Th22) cells as major producers of IL-22. The aim of the present study was to examine the expression of aryl hydrocarbon receptor in patients with AIH and in normal controls. METHODS Levels of mRNA transcripts were measured in the peripheral blood mononuclear cells of 18 patients with AIH and compared with 18 normal controls by a quantitative real-time polymerase chain reaction...
April 2018: Middle East Journal of Digestive Diseases
Lies Hulshof, Saskia A Overbeek, Anne L Wyllie, Mei Ling J N Chu, Debby Bogaert, Wilco de Jager, Leon M J Knippels, Elisabeth A M Sanders, Wim M C van Aalderen, Johan Garssen, Belinda Van't Land, Aline B Sprikkelman
Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in infancy with a complex pathology. In adults, the clinical severity of AD has been associated with increases in T helper cell type (Th) 2, Th22, and Th17 serum markers, including high levels of CC chemokine ligand (CCL) 17 and CCL22 chemokines. Objective: To explore the possible association between serum chemokine levels and AD severity in infants with moderate-to-severe AD and elevated immunoglobulin E (IgE)...
2018: Frontiers in Immunology
Xuehua Chen, Yanfu Wang, Jiali Wang, Jinhui Wen, Xuzhao Jia, Xiaojun Wang, Hua Zhang
Chronic inflammation and immunosuppression lead to aging and tumorigenesis. T-helper 22 (Th22) cells, interleukin 22 (IL-22) and myeloid-derived suppressor cells (MDSCs) serve an important role in inflammatory-immune diseases and cancer. However, the status of Th22 cells, IL-22 and MDSCs in aging and elderly gastric cancer progression is unknown. In the present study, 39 elderly patients with gastric cancer (EGC), 32 elderly healthy controls (HE) and 31 young healthy controls (HY) were enrolled, and the peripheral Th22, Th17 and Th1 cells, and MDSCs, were examined using flow cytometry...
July 2018: Oncology Letters
Juan Manuel Leyva-Castillo, Juhan Yoon, Raif S Geha
BACKGROUND: Serum IL-22 levels are increased in patients with atopic dermatitis, which commonly precedes asthma in the atopic march. Epicutaneous sensitization in mice results in TH 2-dominated skin inflammation that mimics atopic dermatitis and sensitizes the airways for antigen challenge-induced allergic inflammation characterized by the presence of both eosinophils and neutrophils. Epicutaneous sensitization results in increased serum levels of IL-22. OBJECTIVE: We sought to determine the role of IL-22 in antigen-driven airway allergic inflammation after inhalation challenge in epicutaneously sensitized mice...
June 18, 2018: Journal of Allergy and Clinical Immunology
Hossein Akbari, Mostafa Ghardashi, Alireza Soleimani, Hanieh Mohammadi, Hassan Nikoueinejad
A subset of CD4+ T cells named T helper (Th)22 cells play some pathogenic roles in some autoimmune disorders such as type 1 diabetes (T1D). We aimed to study the correlation between the circulatory number of these cells and serum levels of its related cytokines with T1D as well as diabetic complications including metabolic control, atherosclerosis, and nephropathy. Fortynine patients with T1D and 43 healthy controls underwent the assessment of circulatory number of Th22 cells (by flow cytometry), serum level of Th22 related cytokines including Interleukin-22 (IL-22), Interleukin-10 (IL-10), Transforming growth factor-β (TGF-β), Tumor necrosis factor-α (TNF-α) (by ELISA) and carotid intima-media thickness (cIMT) measurement (by doppler ultrasonography)...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
Gholamreza Azizi, Abbas Mirshafiey, Hassan Abolhassani, Reza Yazdani, Alireza Ghanavatinejad, Farshid Noorbakhsh, Nima Rezaei, Asghar Aghamohammadi
Patients with lipopolysaccharides responsive beige-like anchor protein (LRBA) deficiency suffer from a variety of immunological abnormalities. In the current study, we investigated the role of T helper (Th) cell subsets and regulatory T (Treg) cells and their related cytokines and transcription factors in the immune dysregulation of LRBA deficiency. The study population comprised of 13 LRBA-deficient patients and 13 age- and sex-matched healthy controls (HCs). Th subsets and Treg were examined by flow cytometry...
May 28, 2018: Journal of Cellular Physiology
L Xiao, L Bai, M Y Liu, P Xie, T Wang, D P Xiong
Objective: To analyze the expression of IL-22 in nasal polyps and the expression of Th22 cells. Method: The concentrations of IL-22 in nasal polyps were determined by ELISA. The mononuclear cells infiltrated in nasal polyps were separated and flow cytometry was used to analyze the expression of IL-22 in CD4+ T cells and the counts of Th22 cells. Result: Compared with the control group, the expression of IL-22 in nasal polyps did not change significantly, however the expression of IL-22 in CD4+ T cells increased...
November 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
G Monasterio, F Castillo, L Rojas, E A Cafferata, C Alvarez, P Carvajal, C Núñez, G Flores, W Díaz, R Vernal
It is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1β, IL-17 and IL-22, respectively, are associated with pathogenesis of several synovial joint degenerative disorders. During temporomandibular joint osteoarthritis (TMJ-OA), IL-1β and IL-17 have been implicated in the inflammation and resorption of sub-chondral bone; however, the role of Th22 response in the TMJ-OA pathophysiology has not been established...
August 2018: Journal of Oral Rehabilitation
Alexandra Leonard, Emma Guttman-Yassky
Irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) are common skin disorders that are characterized by inflammation, oozing, crusting, and pruritus. Atopic dermatitis (AD) is an inflammatory skin disease characterized by immune and barrier abnormalities and is additionally a risk factor for acquiring ICD and ACD. New work on allergic sensitization to common allergens (e.g., nickel and fragrance) in human skin has shown that different allergens have distinct molecular fingerprinting. For example, nickel promotes strong Th1/Th17 polarization, whereas fragrance allergy causes Th2/Th22 skewing, which is similar to the phenotype of AD...
May 12, 2018: Clinical Reviews in Allergy & Immunology
Minfeng Wu, Yu Deng, Su Li, Yu Chen, Dongjie Guo, Xingxiu Jin, Qi Xu, Bin Li, Fulun Li
Psoriasis is a chronic inflammatory cutaneous disease characterized by clinical manifestations of erythema and white scales. The pathogenesis of psoriasis is not yet clear. Despite a combination of hormonal therapy and physiotherapy used in Western medicine, the condition often relapses after withdrawal of drugs. Traditional Chinese medicine (TCM) has therapeutic features and may be a clinically effective formula by regulating unbalanced immune systems, such as by targeting interleukins. In this paper, we review recent research about how Chinese medicine immunoregulates psoriasis via interleukins, and systematically summarizes the related mechanisms...
2018: American Journal of Chinese Medicine
Farinaze Behfarjam, Zohreh Jadali
IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with vitiligo and in normal controls. Transcript levels were determined by a reverse transcription quantitative real-time polymerase chain reaction. Aryl hydrocarbon receptor mRNA expression was drastically increased in patients with vitiligo compared to healthy controls (P = 0...
March 2018: Anais Brasileiros de Dermatologia
Leilei Fang, Zhi Pang, Weigang Shu, Wei Wu, Mingming Sun, Yingzi Cong, Zhanju Liu
Background: Anti-tumor necrosis factor (TNF) therapy appears to be effective in the treatment of Crohn's disease (CD), a chronic inflammatory disease of the gastrointestinal tract. However, the mechanisms involved are not completely understood. Methods: Fifty-seven active CD patients were enrolled, and cytokine profiles in colonic biopsies of patients with active CD receiving anti-TNF monoclonal antibody (mAb) (infliximab [IFX]) treatment were determined using quantitative real-time polymerase chain reaction (qRT-PCR)...
July 12, 2018: Inflammatory Bowel Diseases
Hassan Doulabi, Maryam Rastin, Hossein Shabahangh, Ghodratollah Maddah, Abbas Abdollahi, Reza Nosratabadi, Seyed-Alireza Esmaeili, Mahmoud Mahmoudi
T-helper (Th) 22 cells are involved in the immunopathogenesis of inflammatory diseases, but their specific role in the immunopathogenesis of cancer is unknown. In this study, we examined the profile of circulating and intratumoral Th17, Th22 and CD4+ cells co-producing IL-17/IL-22 in colon cancer (CC) patients in relation to tumor staging. Thirty newly diagnosed colon cancer (CC) patients participated in this study. The percentage of Th1 (CD4+ IFN-γ+ IL-17- IL-22- ), Th17 (CD4+ IFN-γ- IL-17+ IL-22- ), Th22 (CD4+ IFN-γ- IL-17- IL-22+ ) and CD4+ cells co-producing IL-17/IL-22 (CD4+ IFN-γ- IL-17+ IL-22+ ) in the peripheral blood, tumor and paratumor tissues was assessed by multicolor flow cytometry...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Lu Gan, Xiaozhao Li, Mengyuan Zhu, Chen Chen, Huimin Luo, Qiaoling Zhou
The existing therapies of IgA nephropathy are unsatisfying. Acteoside, the main component of Rehmannia glutinosa with anti-inflammatory and anti-immune effects, can improve urinary protein excretion and immune disorder. Th22 cell is involved in IgA nephropathy progression. This study was determined to explore the effect of acteoside on mesangial injury underlying Th22 cell disorder in IgA nephropathy. Serum Th22 cells and urine total protein of patients with IgA nephropathy were measured before and after six months treatment of Rehmannia glutinosa acteoside or valsartan...
November 2018: Renal Failure
Raquel Leao Orfali, Luanda Mara da Silva Oliveira, Josenilson Feitosa de Lima, Gabriel Costa de Carvalho, Yasmim Alefe Leuzzi Ramos, Natalli Zanete Pereira, Naiura Vieira Pereira, Mariana Colombini Zaniboni, Mirian Nacagami Sotto, Alberto José da Silva Duarte, Maria Notomi Sato, Valeria Aoki
Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization by Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4+/ CD8+ T cells expressing IL-22 in AD skin...
April 27, 2018: Scientific Reports
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