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Hironori Ryota, Mitsuaki Ishida, Sohei Satoi, Hiroaki Yanagimoto, Tomohisa Yamamoto, Hisashi Kosaka, Satoshi Hirooka, So Yamaki, Masaya Kotsuka, Yoichi Matsui, Tsukasa Ikeura, Kazushige Uchida, Makoto Takaoka, Kazuichi Okazaki, Koji Tsuta
AIM: Follicular pancreatitis is a recently recognized, distinct clinicopathological entity characterized by the presence of many intrapancreatic lymphoid follicles with reactive germinal centres. However, the clinicopathological and immunological features and causes have not yet been established. We assessed the clinicopathological and immunological profiles of patients with follicular pancreatitis who underwent surgery. METHODS AND RESULTS: This study included three patients with pancreatic masses (age range: 62-75 years; women:men: 1:2)...
December 4, 2018: Histopathology
Xin Chen, Ruzhi Deng, Wei Chi, Xia Hua, Fan Lu, Fang Bian, Ning Gao, Zhijie Li, Stephen C Pflugfelder, Cintia de Paiva, De-Quan Li
BACKGROUND: While most studies focus on pro-allergic cytokines, the protective role of immunosuppressive cytokines in allergic inflammation is not well elucidated. This study was to explore a novel anti-inflammatory role and cellular/molecular mechanism of IL-27 in allergic inflammation. METHODS: A murine model of experimental allergic conjunctivitis (EAC) was induced in BALB/c, C57BL/6 or IL-27Rα deficient (WSX-1-/- ) mice by short ragweed pollen, with untreated or PBS-treated mice as controls...
December 4, 2018: Allergy
Linda Humbert, Marjorie Cornu, Emmanuelle Proust-Lemoine, Jagadeesh Bayry, Jean-Louis Wemeau, Marie-Christine Vantyghem, Boualem Sendid
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, and adrenal insufficiency. CMC can be complicated by systemic candidiasis or oral squamous cell carcinoma (SCC), and may lead to death. The role of chronic Candida infection in the etiopathogenesis of oral SCC is unclear. Long-term use of fluconazole has led to the emergence of Candida albicans strains with decreased susceptibility to azoles...
2018: Frontiers in Immunology
Mehdi Najar, Hussein Fayyad-Kazan, Wissam H Faour, Makram Merimi, Etienne M Sokal, Catherine A Lombard, Hassan Fahmi
OBJECTIVE AND DESIGN: The objective of the study is to uncover the influence of human bone marrow-derived mesenchymal stem cells (BM-MSCs) on the generation of Th17 lymphocytes in co-cultures of both BM-MSCs and T cells. MATERIALS AND METHODS: BM-MSCs, characterized according to the international society for cellular therapy (ISCT) criteria, were co-cultured with T cells isolated from peripheral blood. The expression levels of IL-17 receptor, RORγt and IL-23 receptor were evaluated using flow cytometry...
November 30, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Mojibade Hassan, Alina Ulezko Antonova, Jian Ming Li, Sakura Hosoba, Manali Rupji, Jeanne Kowalski, Adam J Perricone, David L Jaye, Henry Marsh, Michael Yellin, Steven Devine, Edmund K Waller
Higher numbers of donor plasmacytoid dendritic cells (pDC) increased survival and reduced graft-versus-host disease (GvHD) in human recipients of unrelated donor bone marrow (BM), but not G-CSF peripheral blood grafts. In murine models, we have shown that donor BM pDC increase survival and decrease GvHD compared to G-CSF-mobilized pDC. To increase the content of pDC in BM grafts we studied the effect of FMS-like tyrosine kinase 3 ligand (Flt3L) treatment of murine BM donors on transplant outcomes. Flt3L treatment (300μg/kg/day) resulted in a schedule-dependent increase in the content of pDC in the marrow...
November 29, 2018: Biology of Blood and Marrow Transplantation
Narges Dargahi, Joshua Johnson, Osaana Donkor, Todor Vasiljevic, Vasso Apostolopoulos
As a person ages, physiological, immunological and gut microbiome changes collectively result in an array of chronic conditions. According to the 'hygiene hypothesis' the increasing prevalence of immune-mediated disorders may be related to intestinal dysbiosis, leading to immune dysfunction and associated conditions such as eczema, asthma, allergies and autoimmune diseases. Beneficial probiotic bacteria can be utilized by increasing their abundance within the gastrointestinal lumen, which in turn will modulate immune cells, such as, T helper (Th)-1, Th2, Th17, regulatory T (Treg) cells and B cells, which have direct relevance to human health and the pathogenesis of immune disorders...
January 2019: Maturitas
Aditi Sinha, Mamta Puraswani, Mani Kalaivani, Pragya Goyal, Pankaj Hari, Arvind Bagga
Both levamisole and mycophenolate mofetil (MMF) prevent relapses in patients with frequently relapsing nephrotic syndrome; however, their efficacy has not been compared prospectively. This single-center, randomized, open-label trial enrolled 149 children ages 6-18 years with frequently relapsing or steroid-dependent nephrotic syndrome. Participants were randomized in a 1:1 ratio to receive therapy with MMF (750-1000 mg/m2 daily) or levamisole (2-2.5 mg/kg on alternate days) for 1 year; prednisolone was discontinued by 2-3 months...
November 22, 2018: Kidney International
Gabriele Schramm, Abdulhadi Suwandi, Alibek Galeev, Samriti Sharma, Janin Braun, Anne-Kathrin Claes, Peter Braubach, Guntram A Grassl
Countries with a high incidence of helminth infections are characterized by high morbidity and mortality to infections with intracellular pathogens such as Salmonella . Some patients with Salmonella - Schistosoma co-infections develop a so-called "chronic septicemic salmonellosis," with prolonged fever and enlargement of the liver and spleen. These effects are most likely due to the overall immunoregulatory activities of schistosomes such as induction of Tregs, Bregs, alternatively activated macrophages, and degradation of antibodies...
2018: Frontiers in Immunology
Zhi Li, Zhe-Feng Chen, Jiu-Xiang Liu, Feng Liu
OBJECTIVE: To compare mid-term clinical results of total hip arthroplasty (THA) with metal-on-metal (MoM) and metal-on-polyethylene (MoP) bearings and to evaluate the biological safety of the two kinds of prostheses. METHODS: Thirty-two patients who received a primary THA with an MoM articulation between January 2008 and December 2010 were selected to form the MoM group retrospectively. The MoP group consisted of 32 patients who received a THA with an MoP prosthesis during the same period...
November 2018: Orthopaedic Surgery
Kunjan Khanna, Kamla Prasad Mishra, Sudipta Chanda, Malleswara Rao Eslavath, Lilly Ganju, Bhuvnesh Kumar, Shashi Bala Singh
Khanna, Kunjan, K.P. Mishra, Sudipta Chanda, Malleswara Rao Eslavath, Lilly Ganju, Bhuvnesh Kumar, and Shashi Bala Singh. Effects of acute exposure to hypobaric hypoxia on mucosal barrier injury and the gastrointestinal immune axis in rats. High Alt Med Biol 00:000-000, 2018.-High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation are the major problems induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up to 14 days at 7620 m on GI immune function have been studied...
November 28, 2018: High Altitude Medicine & Biology
Haideh Namdari, Maryam Izad, Farhad Rezaei, Zahra Amirghofran
CD4+ T cell subsets including regulatory T cells (Tregs), Th1 and Th17 are critical for control and development of inflammation and autoimmunity. We investigated the in vitro and in vivo effects of silymarin, a well-known herbal medicine on differentiation and function of Tregs and Th1 and Th17 responses. For in vitro study, mice splenocytes treated with 20-30 μg/ml silymarin were evaluated for gene expressions of specific transcription factors and cytokines of CD4+ T cell subsets using real-time PCR. Induction of Treg cell development in the presence of silymarin was performed on isolated naïve CD4+ T cells...
November 26, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Mingming Sun, Chong He, Liang Chen, Wenjing Yang, Wei Wu, Feidi Chen, Anthony T Cao, Suxia Yao, Sara M Dann, T G Murali Dhar, Luisa Salter-Cid, Qihong Zhao, Zhanju Liu, Yingzi Cong
The role of retinoid-related orphan receptor γ t (RORγt) in Th17 cell differentiation has been well established; however, how it regulates other T cell lineages is still not clearly understood. In this study, we report that in mice, while promoting Th17 cell differentiation, RORγt inhibited IL-10 production by T cells, thereby preserving the pathogenicity of Th17 cells. Treatment with RORγ t -specific inhibitor suppressed Th17 cell signature cytokines, but promoted IL-10 production. RORγt inhibitor-treated Th17 cells induce less severe colitis compared with control Th17 cells...
November 26, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Mirjana Dimitrijević, Nevena Arsenović-Ranin, Duško Kosec, Biljana Bufan, Mirjana Nacka-Aleksić, Ivan Pilipović, Gordana Leposavić
Collagen type II-induced arthritis (CIA) in Dark Agouti rats, a model of rheumatoid arthritis (RA), reproduces sexual dimorphism in incidence and severity of the human disease. Th17 cells are central in the induction/propagation of autoimmune inflammation in CIA and RA. To assess mechanisms underlying this dimorphism in CIA rats, in lymph nodes draining inflamed joints and adjacent tissues (dLNs) from CIA rats of both sexes Th17/CD25+Foxp3+CD4+ T-regulatory cell (Treg) ratio, Th17 cell redifferentiation in functionally distinct subsets and Treg transdifferentiation into IL-17-producing cells (exTregs) were examined...
November 23, 2018: Brain, Behavior, and Immunity
Felix I L Clanchy, Richard O Williams
OBJECTIVE: Ibudilast is a well-tolerated, orally available type 4 phosphodiesterase (PDE4) inhibitor used to treat asthma and stroke. As PDE4 inhibition suppresses inflammatory mediator production and cell proliferation in leukocytes, ibudilast may be a valuable therapy for the treatment of inflammatory auto-immune diseases such as rheumatoid arthritis (RA). We assessed the therapeutic potential of ibudilast by measuring its capacity to modulate inflammation in human leukocytes, RA synovial fibroblasts (RASF) and in experimental arthritis...
November 26, 2018: Arthritis & Rheumatology
Taylor A Doherty, David H Broide
The recent discovery of innate lymphoid cells has revolutionized our understanding of the pathogenesis of immune diseases including allergy and asthma. Innate lymphoid cells (ILCs) are a heterogeneous collection of lymphocytes that lack antigen-specificity (non-T, non-B cells) and potently produce characteristic cytokines of T cell subsets (Th1, Th2, Th17). ILCs are divided into group 1 (ILC1s), group 2 (ILC2s), or group 3 (ILC3s). Similar to Th2 cells, ILC2s produce IL-4, IL-5, and IL-13, among others, and are present in increased numbers in samples from patients with many allergic disorders including asthma and chronic rhinosinusitis (CRS)...
November 22, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
Malena M Pérez, Larissa M S Martins, Murilo S Dias, Camila A Pereira, Jefferson A Leite, Enrico C S Gonçalves, Paula Z de Almeida, Emanuelle N de Freitas, Rita C Tostes, Simone G Ramos, Marcel R de Zoete, Bernhard Ryffel, João S Silva, Daniela Carlos
Sound evidence supports a role for interleukin-17 (IL-17)-producing delta-gamma (γδ) T cells and IL-17-producing helper T cells (Th17) in intestinal homeostasis, especially in intestinal barrier integrity. In the present study, we aimed to evaluate the role of IL-17 cytokine in the regulation of intestinal immunity and obesity-induced metabolic syndrome (MetS) in an experimental murine model. C57BL/6 wild-type (WT) mice and mice lacking the IL-17 cytokine receptor (IL-17RA-/- ) were fed either a control diet (CD) or a high-fat diet (HFD) for nine weeks...
November 25, 2018: Immunology
Zihan Zheng, Feng Zheng
Type 1 diabetes (T1D) is an autoimmune disease centered around the loss of the beta cells of the islets of Langerhans, and consequent inability of the islets to produce the insulin necessary to maintain glycemic control. While most therapeutic approaches have been centered on insulin replacement, newer approaches to target the underlying immune response have become an area of focus. However, the immune landscape in T1D is extremely complex, and the roles played by individual cytokines during disease progression are incompletely understood, making the development of immunotherapies very difficult...
November 22, 2018: Molecular Immunology
Lauren M Osborne, Amitoj Brar, Sabra L Klein
T cells play a key role in adaptive immune responses, and shifts among T cell classes occur in normal pregnancy. There is evidence for the role of TH 17 cells and dysregulation of the TH 17:Treg cell balance in morbidities and autoimmune diseases during pregnancy. Because TH 17 responses may play a role in depression and anxiety outside of pregnancy, we hypothesize that TH 17 responses and the balance of TH 17:Treg activity may also contribute to the development of depression and anxiety during pregnancy. To explore this hypothesis, this review has three main aims: 1) to evaluate systematically the role of TH 17 cells and cytokines during pregnancy; 2) to compare changes in the ratio of TH 17:Treg cells during pregnancy morbidities with the changes that occur in depression and anxiety outside of pregnancy; and 3) to provide a basis for further research on TH 17 cells in perinatal mood and anxiety disorders, with an eye toward the development of novel therapeutics...
November 19, 2018: Brain, Behavior, and Immunity
Sergej Tomić, Nataša Ilić, Vanja Kokol, Alisa Gruden-Movsesijan, Dušan Mihajlović, Marina Bekić, Ljiljana Sofronić-Milosavljević, Miodrag Čolić, Dragana Vučević
Background: Cellulose nanofibrils (CNF) are attractive nanomaterials for various biomedical applications due to their excellent biocompatibility and biomimetic properties. However, their immunoregulatory properties are insufficiently investigated, especially in relation to their functionalization, which could cause problems during their clinical application. Methods: Using a model of human dendritic cells (DC), which have a central role in the regulation of immune response, we investigated how differentially functionalized CNF, ie, native (n) CNF, 2,2,6,6-tetramethylpiperidine 1-oxyl radical-oxidized (c) CNF, and 3-aminopropylphosphoric acid-functionalized (APAc) CNF, affect DC properties, their viability, morphology, differentiation and maturation potential, and the capacity to regulate T cell-mediated immune response...
2018: International Journal of Nanomedicine
Ruiqi Wang, Ping Wang, Guangsheng DU
Objective To elucidate how high-mobility group box 1 (HMGB1) exacerbates myocardial damage and infuences CD4+ , CD8+ and Th17 T lymphocytes of spleen through Toll like receptor 4 (TLR4) in ischemia myocardial injury. Methods 30 wild-type (WT) and 30 TLR4 knockout (TLR4-/- ) C57BL/6 mice were randomly divided into the control group, isoproterenol induced ischemia myocardial damage group (ISO) and ISO-rHMGB1 group. The cardiac function of mice was evaluated by echocardiography, and the pathological changes of myocardial tissue were observed by HE staining and Sirius red staining...
September 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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