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https://www.readbyqxmd.com/read/30111479/-17%C3%AE-hydroxylase-deficiency-with-severe-hypertension-as-the-initial-symptom-in-a-child
#1
Hong-Ling Wei, Shan Lu, Xin-Li Wang, Jia-Wei Li, Yun-Pu Cui, Yan-Sheng Yao
A 14-year-old female (social gender) patient was admitted to the hospital due to severe hypertension for 11 days. The patient had primary amenorrhea. The blood pressure was 146/90 mm Hg. The skin color was slightly black. The development of secondary sexual characteristics was poor. The labia majora could be observed in the vulva. However, the labia minora, clitoris, vagina, and hymen were absent. The levels of renin, cortisol, and sex hormone were low, while the levels of adrenocorticotropic hormone and gonadotropin were high...
August 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30108549/depression-and-obesity-integrating-the-role-of-stress-neuroendocrine-dysfunction-and-inflammatory-pathways
#2
REVIEW
Silvia R S Ouakinin, David P Barreira, Carlos J Gois
Literature on depression and obesity describes the relevance of the hypothalamic pituitary adrenal axis dysfunction, sympathetic nervous system (SNS) activation, and inflammatory processes as well as the interaction of genetic and environmental factors. Recent investigation in obesity highlights the involvement of several regulation systems, particularly in white adipose tissue. The hypothalamic pituitary adrenal axis, gonadal, growth hormone, leptin, sympathetic nervous system and adrenergic, dopaminergic, and serotoninergic central pathways, all seem interconnected and involved in obesity...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30105106/successful-management-of-pheochromocytoma-detected-in-pregnancy-by-interval-adrenalectomy-in-a-vhl-patient
#3
V T S Kaluarachchi, Uditha Bulugahapitiya, Maulee Arambewela, Sonali Gunathilake
A 34-year-old mother with diabetes mellitus for 6 years presented in the late second trimester of her third pregnancy with new onset hypertension and characteristic hyperadrenergic spells. Clinical examination was unremarkable except a blood pressure of 170/110 mmhg. She had an elevated 24 hour urinary normetanephrine level with ultrasonic evidence of a hyperechoic hypervascular well-defined right supra renal mass of 6 x 5 cm in size which was very suggestive of a pheochromocytoma. Her management decisions were made by a multidisciplinary team which decided to deliver the baby by lower segment cesarean section (LSCS) as the pregnancy was advanced and to proceed with interval adrenalectomy after contrast enhanced computer tomography (CECT) of the abdomen with adrenal protocol...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/30104897/sudden-onset-flank-pain-a-case-report-of-retroperitoneal-hemorrhage-secondary-to-a-ruptured-adrenal-hemangioma
#4
Xufeng Peng, Wenqiang Luo, Xinru Zhang, Weidong Zhu
Background: Acute abdominal pain is a common complaint of patients presenting at the emergency department (ED). It can be caused by a broad spectrum of diseases. Providing care for patients with acute abdominal pain requires familiarity with the epidemiology, prevalence, and presentation of abdominal pathology, as well as a working knowledge of the differential diagnoses. Case report: In this article, we discuss a case of spontaneous rupture of adrenal hemangioma with large retroperitoneal hemorrhage in a 31-year-old female...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/30104119/immune-checkpoint-inhibitor-therapy-induced-hypophysitis-%C3%A2-a-case-series-of-taiwanese-patients
#5
Chia-Hung Lin, Kuan-Hua Chen, Kuan-Yu Chen, Shyang-Rong Shih, Jin-Ying Lu
Immune checkpoint blockade-based immunotherapy is a new modality of cancer treatment with a unique mechanism that has gained increased numbers of indication and is now used in several cancer types. However, immune-related adverse events (irAEs) emerge as a new entity of diseases involving one or multiple organ systems. irAEs could result in interruption of immunotherapy, morbidities or even death. Among various manifestations of irAEs, immune-mediated hypophysitis is rare but important, requiring prompt diagnosis and treatment to avoid life-threatening conditions...
August 10, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/30103936/dha-enriched-re-esterified-triacylglycerol-fish-oil-supplementation-and-oily-fish-consumption-enhance-red-blood-n-3-fatty-acid-index-in-omani-pre-adolescent-schoolchildren
#6
S S Al-Ghannami, E Sedlak, I S Hussein, Y Min, S M Al-Shmmkhi, H S Al-Oufi, A Al-Mazroui, P Clough, K Ghebremeskel
Dietary habits of Omani population particularly of children and young adults have changed significantly. Consumption of imported calorie-dense foods, vegetable oils, milled and polished grains and carbonated beverages have become the norm. Concomitantly, there has been an exponential increase in the prevalence of non-communicable diseases. The impact of the westernisation of eating habits on children has not been evaluated. We have investigated blood fatty acid profile of male (n = 125) and female (n = 160) children aged 9 and 10 (9...
August 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/30103807/multiple-myeloma-concealed-by-adrenal-cushing-syndrome-a-case-report-and-review-of-the-literature
#7
Taweesak Wannachalee, Nuttagarn Jantanapornchai, Kittima Suphadirekkul, Sirinart Sirinvaravong, Weerapat Owattanapanich
BACKGROUND: Cushing syndrome coexisting with multiple myeloma has been previously described in a few reports. Overlapping clinical manifestations can lead to misdiagnoses. CASE PRESENTATION: We presented an extremely rare case of a 33-year-old Thai woman with concomitant kappa light chain myeloma with adrenal Cushing syndrome, both of which were related to skeletal manifestations. A precedence report indicated that treatment of the Cushing syndrome could exacerbate the myeloma symptoms...
August 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30101877/-a-case-of-leptomeningeal-carcinomatosis-involving-loss-of-eyesight-after-total-gastrectomy-for-gastric-cancer
#8
Marie Kurebayashi, Akira Hashimoto, Youhei Ikenoyama, Yuichi Tahara, Hiroyuki Fuke, Atsuya Shimizu, Masahide Kondo, Hiroshi Nakano, Toshiya Kosaka
A 78-year-old woman had undergone total gastrectomy and chemotherapy for gastric cancer (pT4N3bM0 Stage IIIC, poorly differentiated adenocarcinoma). She received S-1 monotherapy 3 times weekly (S-1 at 80mg twice daily for 14 days, every 3 weeks). She underwent routine examinations, including tumor markers and computed tomography. She had no signs of recurrent disease, but she suffered from a loss of eyesight 2 years and 8 months after the operation. A choked disc was found, but she had no headaches, nausea, or unconsciousness, which indicated high intraventricular pressure...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/30101134/fatal-disseminated-cytomegalovirus-infection-with-necrotizing-oophoritis-in-a-patient-with-acquired-immunodeficiency-syndrome
#9
Laís Braga Soares, Renata Buccheri, Renata Bacic Palhares, Amaro Nunes Duarte-Neto
Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases...
July 2018: Autopsy & Case Reports
https://www.readbyqxmd.com/read/30100004/evaluation-and-treatment-of-adrenal-dysfunction-in-the-primary-care-environment
#10
REVIEW
Shannon Cole
Adrenal insufficiency (Addison's disease) and Cushing's syndrome are rare disorders characterized by abnormal secretion of adrenal hormones. All patients with adrenal insufficiency and many with Cushing's syndrome require life-long therapy with the potential to impact the quality of life. Management requires gain of a significant amount of knowledge related to treatment, self-care, and how to react quickly in critical situations. Knowledge deficits related to management may cause patients to become critically ill and may even cause death...
September 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/30094109/a-case-of-brugada-pattern-associated-with-adrenal-insufficiency
#11
Corina Iorgoveanu, Ahmed Zaghloul, Aakash Desai, Kathir Balakumaran, Muhammad Y Adeel
Brugada syndrome (BrS) is an inherited channelopathy disease, caused by genetic changes in transmembrane ion channels. It has an increased risk of sudden cardiac death (SCD) in the absence of a structural heart disease. We report a case in which the presenting electrocardiogram (EKG) exhibited a type 1 Brugada-like pattern during an adrenal crisis with transformation into a type 2 Brugada-like pattern as the crisis improved.
June 6, 2018: Curēus
https://www.readbyqxmd.com/read/30094023/hyponatremia-in-kidney-transplant-patients-its-pathophysiologic-mechanisms
#12
Carlos G Musso, Alejandrina Castañeda, María Giordani, Cesar Mombelli, Silvia Groppa, Nora Imperiali, Guillermo Rosa Diez
Kidney transplant patients (KTPs), and particularly those with advanced chronic kidney rejection, may be affected by opportunistic infections, metabolic alterations and vascular and oncologic diseases that promote clinical conditions that require a variety of treatments, the combinations of which may predispose them to hyponatremia. Salt and water imbalance can induce abnormalities in volemia and/or serum sodium depending on the nature of this alteration (increase or decrease), its absolute magnitude (mild or severe) and its relative magnitude (body sodium:water ratio)...
August 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/30093497/delayed-presentation-of-isolated-adrenocorticotropin-insufficiency-after-nivolumab-therapy-for-advanced-non-small-cell-lung-carcinoma-nsclc
#13
Shiva Shrotriya, Manoj P Rai, Ahmad Alratroot, Erin Sarzynski
We describe a 73-year-old man who developed adrenal insufficiency 7 months after completing nivolumab therapy for advanced non-small cell lung cancer. He presented with non-specific symptoms of malaise and fatigue with an insidious 13.6 kilogram weight loss, prompting an evaluation for disease progression, which was negative. Subsequent evaluation revealed isolated adrenocorticotropin insufficiency as the aetiology, attributed to a delayed side effect of nivolumab therapy.
August 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30093212/genetics-of-micronodular-adrenal-hyperplasia-and-carney-complex
#14
Amit Tirosh, Nuria Valdés, Constantine A Stratakis
Micronodular bilateral adrenal hyperplasia (MiBAH) is a rare cause of adrenal Cushing syndrome (CS). The investigations carried out on this disorder during the last two decades suggested that it could be divided into at least two entities: primary pigmented nodular adrenocortical disease (PPNAD) and isolated micronodular adrenocortical disease (i-MAD). The most common presentation of MiBAH is familial PPNAD as part of Carney complex (CNC) (cPPNAD). CNC, associated with multiple endocrine and non-endocrine neoplasias, was first described in 1985 in 40 patients, 10 of whom were familial cases...
August 6, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/30092813/smith-lemli-opitz-syndrome-presenting-as-acute-adrenal-crisis-in-a-child-a-case-report
#15
Chamara Jayamanne, Sajith Sandamal, Kasun Jayasundara, Mayoorathy Saranavabavananthan, Sachith Mettananda
BACKGROUND: Smith-Lemli-Opitz syndrome is a rare autosomal recessive disorder of cholesterol biosynthesis which is characterized by multiple congenital malformations and global developmental delay. Here we report the case of a 3-year-old, previously undiagnosed, child with Smith-Lemli-Opitz syndrome presenting with acute adrenal crisis, which is an extremely rare and atypical presentation of this disease. CASE PRESENTATION: A 3-year-old Sri Lankan Sinhalese boy without evidence of infection presented with circulatory collapse...
August 10, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30092401/akebia-saponin-d-reverses-corticosterone-hypersecretion-in-an-alzheimer-s-disease-rat-model
#16
Yuhui Wang, Jinyang Shen, Xiaolin Yang, Ye Jin, Zhonglin Yang, Rufeng Wang, Fuming Zhang, Robert J Linhardt
BACKGROUND: Glucocorticoid hormones are implicated in the pathogenesis of Alzheimer's disease (AD) and other diseases including diabetes, hyperlipidemia, and osteoporosis. Akebia saponin D (ASD) possesses numerous pharmacological activities, including as an anti-AD, anti-hyperlipidemia, anti-diabetes, and anti-osteoporosis agent. The anti-AD effect of ASD is possibly through its regulation of glucocorticoid levels. PURPOSE: The present study was undertaken to investigate the neuroprotective effects of ASD on Aβ25-35 -induced cognitive deficits and to elucidate its underlying mechanism of action...
August 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30091025/does-the-omission-of-vincristine-in-patients-with-diffuse-large-b-cell-lymphoma-affect-treatment-outcome
#17
Charlott Mörth, Antonios Valachis, Amal Abu Sabaa, Daniel Molin, Max Flogegård, Gunilla Enblad
The standard treatment for diffuse large B cell lymphoma (DLBCL) is rituximab with CHOP (cyclophosphamide, doxorubicin, vincristine (VCR), and prednisone). Maintaining high dose intensity of cytotoxic treatment has been associated with better outcome but little is known about the role of maintaining VCR. This study aimed to answer whether the omission of vincristine due to neurotoxicity affects patient outcome. A Swedish cohort of patients primarily treated with curative intent for DLBCL or high-grade malignant B cell lymphoma was retrospectively analyzed...
August 8, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30090934/risk-factors-associated-with-perioperative-complications-and-prolonged-length-of-stay-after-laparoscopic-adrenalectomy
#18
Yufei Chen, Anouk Scholten, Kathryn Chomsky-Higgins, Iheoma Nwaogu, Jessica E Gosnell, Carolyn Seib, Wen T Shen, Insoo Suh, Quan-Yang Duh
Importance: Laparoscopic adrenalectomy is the gold standard for most adrenal disorders and its frequency in the United States is increasing. While national and administrative databases can adjust for patient factors, comorbidities, and institutional variations, granular disease-specific data that may significantly influence the incidence of perioperative complications and length of stay (LOS) are lacking. Objective: To investigate factors associated with perioperative complications and LOS after laparoscopic adrenalectomy...
August 8, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/30090628/nephrotic-syndrome-and-adrenal-insufficiency-caused-by-a-variant-in-sgpl1
#19
Natália Duarte Linhares, Rodrigo Rezende Arantes, Stanley Almeida Araujo, Sergio D J Pena
Little is known about the molecular pathogenesis of congenital nephrotic syndrome in association with primary adrenal insufficiency. Most recently, three groups found concurrently the underlying genetic defect in the gene sphingosine-1-phosphate lyase 1 ( SGPL1 ) and called the disease nephrotic syndrome type 14 (NPHS14). In this report we have performed whole-exome sequencing and identified a new homozygous variant in SGPL1 , p.Arg340Trp, in a girl with nephrotic syndrome and Addison's disease. Her brother died previously with the same phenotype and hyperpigmentation of the skin...
August 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/30089287/the-mri-sepsis-score-an-innovative-tool-for-the-evaluation-of-septic-peritonitis-in-mice-using-7-tesla-small-animal-mri
#20
Stephan Diedrich, Julia van der Linde, Michael Nielson, Pia Menges, Jens-Peter Kühn, Andre Käding, Dung Ngyuen Trung, Claus-Dieter Heidecke, Lars Ivo Partecke, Wolfram Kessler
BACKGROUND: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. The most frequently employed readout parameter in mouse CASP studies is prolonged or decreased rate of survival. Monitoring the progression of peritonitis via MRI could provide a helpful tool in the evaluation of severity...
August 8, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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